RPS27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.71759461
2* cotranslational protein targeting to membrane (GO:0006613)9.59186300
3* protein targeting to ER (GO:0045047)9.55732035
4* translational elongation (GO:0006414)9.44337769
5* establishment of protein localization to endoplasmic reticulum (GO:0072599)9.14189660
6maturation of SSU-rRNA (GO:0030490)9.05864421
7* protein localization to endoplasmic reticulum (GO:0070972)8.95187991
8* viral life cycle (GO:0019058)8.82631628
9* cellular protein complex disassembly (GO:0043624)8.78566229
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.65921525
11* translational initiation (GO:0006413)7.84097601
12* protein complex disassembly (GO:0043241)7.55160169
13ribosomal large subunit biogenesis (GO:0042273)7.35529140
14* macromolecular complex disassembly (GO:0032984)7.06520554
15* protein targeting to membrane (GO:0006612)6.34818510
16* nuclear-transcribed mRNA catabolic process (GO:0000956)6.03366855
17* mRNA catabolic process (GO:0006402)5.74590638
18* translation (GO:0006412)5.44568593
19establishment of protein localization to mitochondrial membrane (GO:0090151)5.36092038
20* RNA catabolic process (GO:0006401)5.19628420
21ribonucleoprotein complex biogenesis (GO:0022613)4.88186733
22sequestering of actin monomers (GO:0042989)4.81806862
23DNA deamination (GO:0045006)4.39728988
24chaperone-mediated protein transport (GO:0072321)4.30333308
25* establishment of protein localization to membrane (GO:0090150)4.25044017
26ATP biosynthetic process (GO:0006754)3.96001727
27otic vesicle formation (GO:0030916)3.94420237
28* protein targeting (GO:0006605)3.88097380
29rRNA processing (GO:0006364)3.84535543
30hydrogen ion transmembrane transport (GO:1902600)3.81945027
31inner mitochondrial membrane organization (GO:0007007)3.76014536
32mitochondrial respiratory chain complex assembly (GO:0033108)3.76005478
33cellular component biogenesis (GO:0044085)3.75831927
34* establishment of protein localization to organelle (GO:0072594)3.74256086
35rRNA metabolic process (GO:0016072)3.70889460
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68529290
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.68529290
38NADH dehydrogenase complex assembly (GO:0010257)3.68529290
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58268408
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46761690
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.42521110
42proton transport (GO:0015992)3.39186293
43* protein localization to membrane (GO:0072657)3.34870086
44hydrogen transport (GO:0006818)3.32336174
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23523264
46ATP synthesis coupled proton transport (GO:0015986)3.23523264
47positive regulation of respiratory burst (GO:0060267)3.15783654
48ncRNA 3-end processing (GO:0043628)3.11965305
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05195208
50regulation of mitochondrial translation (GO:0070129)3.01014788
51transcription elongation from RNA polymerase III promoter (GO:0006385)2.99169379
52termination of RNA polymerase III transcription (GO:0006386)2.99169379
53GTP biosynthetic process (GO:0006183)2.98381034
54ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95573435
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95441731
56neuron fate determination (GO:0048664)2.94969020
57spliceosomal complex assembly (GO:0000245)2.92787259
58proteasome assembly (GO:0043248)2.92326752
59platelet dense granule organization (GO:0060155)2.84103911
60midbrain development (GO:0030901)2.82498330
61response to interferon-beta (GO:0035456)2.81860341
62lateral sprouting from an epithelium (GO:0060601)2.81405913
63behavioral response to nicotine (GO:0035095)2.76346003
64formation of translation preinitiation complex (GO:0001731)2.76247048
65intracellular protein transmembrane import (GO:0044743)2.75964438
66* cellular component disassembly (GO:0022411)2.75784436
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72211896
68chromatin remodeling at centromere (GO:0031055)2.69340650
69* protein localization to organelle (GO:0033365)2.67038215
70UTP biosynthetic process (GO:0006228)2.66629734
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66420467
72spliceosomal snRNP assembly (GO:0000387)2.65172556
73CENP-A containing nucleosome assembly (GO:0034080)2.64249048
74protein-cofactor linkage (GO:0018065)2.60565724
75oxidative phosphorylation (GO:0006119)2.60085229
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58832810
77nucleoside triphosphate biosynthetic process (GO:0009142)2.54599634
78establishment of integrated proviral latency (GO:0075713)2.52746414
79tongue development (GO:0043586)2.51197601
80regulation of respiratory burst (GO:0060263)2.50823633
81pseudouridine synthesis (GO:0001522)2.49491308
82ncRNA processing (GO:0034470)2.49314491
83purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.48417287
84purine nucleoside monophosphate biosynthetic process (GO:0009127)2.48417287
85CTP metabolic process (GO:0046036)2.44773775
86CTP biosynthetic process (GO:0006241)2.44773775
87epithelial cilium movement (GO:0003351)2.44047406
88respiratory electron transport chain (GO:0022904)2.43813346
89somite development (GO:0061053)2.42265886
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41974400
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41974400
92histone mRNA metabolic process (GO:0008334)2.40070778
93* gene expression (GO:0010467)2.39354391
94electron transport chain (GO:0022900)2.38221712
95definitive hemopoiesis (GO:0060216)2.37712368
96establishment of viral latency (GO:0019043)2.34933356
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34281704
98DNA damage response, detection of DNA damage (GO:0042769)2.32658340
99lymphoid progenitor cell differentiation (GO:0002320)2.27813415
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27556179
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.26826008
102negative regulation of ligase activity (GO:0051352)2.26715950
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.26715950
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.26248024
105pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.25063306
106telomere maintenance via semi-conservative replication (GO:0032201)2.24974750
107positive regulation of gastrulation (GO:2000543)2.24458567
108mitochondrial transport (GO:0006839)2.23850487
109cytochrome complex assembly (GO:0017004)2.23716879
110UTP metabolic process (GO:0046051)2.23189762
111negative regulation of RNA splicing (GO:0033119)2.23042807
112signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.22974217
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.22974217
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.22974217
115termination of RNA polymerase I transcription (GO:0006363)2.22952498
116transcription elongation from RNA polymerase I promoter (GO:0006362)2.22630343
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.21605638
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.20168506
119cellular response to interferon-beta (GO:0035458)2.19630714
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.18716005
121ncRNA metabolic process (GO:0034660)2.16768207
122transcription-coupled nucleotide-excision repair (GO:0006283)2.16451168
123mature B cell differentiation (GO:0002335)2.15125861
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.15124936
125rRNA modification (GO:0000154)2.13861741
126ribonucleoprotein complex assembly (GO:0022618)2.13323920
127positive regulation of gamma-delta T cell activation (GO:0046645)2.12937285
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.12501887
129guanosine-containing compound biosynthetic process (GO:1901070)2.08267593
130mature B cell differentiation involved in immune response (GO:0002313)2.08083890
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.07251796
132protein complex biogenesis (GO:0070271)2.06902164
1337-methylguanosine mRNA capping (GO:0006370)2.06468586
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.04920809
1357-methylguanosine RNA capping (GO:0009452)2.04835807
136RNA capping (GO:0036260)2.04835807
137DNA strand elongation involved in DNA replication (GO:0006271)2.04827094
138pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.04469218
139DNA-templated transcription, termination (GO:0006353)2.03388117
140protein neddylation (GO:0045116)2.03175511
141transcription from RNA polymerase I promoter (GO:0006360)2.01238519
142ribonucleoprotein complex subunit organization (GO:0071826)2.00709898
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.00603489
144antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.00603489
145DNA ligation (GO:0006266)2.00491222
146* viral transcription (GO:0019083)12.0015763
147ribosomal small subunit assembly (GO:0000028)11.5291972
148* translational termination (GO:0006415)11.4492001
149ribosomal small subunit biogenesis (GO:0042274)10.8308007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.62778820
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.62678719
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.74363442
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.69986300
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.56691922
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.50466152
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34746523
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15146718
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.13129576
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.11052742
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98762934
12E2F7_22180533_ChIP-Seq_HELA_Human2.98063091
13* XRN2_22483619_ChIP-Seq_HELA_Human2.82122382
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78348762
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77985473
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69619541
17EZH2_22144423_ChIP-Seq_EOC_Human2.62046468
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59798643
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59235837
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56457939
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52978440
22* TTF2_22483619_ChIP-Seq_HELA_Human2.49050487
23* VDR_23849224_ChIP-Seq_CD4+_Human2.49002998
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48049097
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45309179
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42702583
27* ELK1_19687146_ChIP-ChIP_HELA_Human2.40155525
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.37025287
29FOXP3_21729870_ChIP-Seq_TREG_Human2.25148823
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.23944009
31DCP1A_22483619_ChIP-Seq_HELA_Human2.11367715
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11259874
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09334398
34* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.04503880
35E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00064937
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.99871150
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99624759
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96387881
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95147619
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88710718
41VDR_22108803_ChIP-Seq_LS180_Human1.84436270
42FUS_26573619_Chip-Seq_HEK293_Human1.84193001
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79813996
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77443333
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.75878907
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73627079
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67549884
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66618374
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.65116642
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62492833
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60000041
52EWS_26573619_Chip-Seq_HEK293_Human1.58712370
53SCL_19346495_ChIP-Seq_HPC-7_Human1.58313484
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56271355
55* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56261766
56* MYC_18940864_ChIP-ChIP_HL60_Human1.55440078
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.53664056
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53163242
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.53058881
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.52035871
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51867341
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51266575
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.46849555
64SPI1_23547873_ChIP-Seq_NB4_Human1.46506750
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42889596
66ZNF274_21170338_ChIP-Seq_K562_Hela1.39988411
67VDR_21846776_ChIP-Seq_THP-1_Human1.39924855
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38894667
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36909937
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.36719167
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.30560261
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29523963
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29260639
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28074706
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26746836
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26053948
77GABP_19822575_ChIP-Seq_HepG2_Human1.24004509
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21664740
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15296648
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.14290427
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13412223
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12920795
83* MAF_26560356_Chip-Seq_TH2_Human1.12123801
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11811746
85MYC_22102868_ChIP-Seq_BL_Human1.11726427
86* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11336778
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10194368
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07409424
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.07387556
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06888908
91IRF1_19129219_ChIP-ChIP_H3396_Human1.05651727
92* YY1_21170310_ChIP-Seq_MESCs_Mouse1.04198009
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03049173
94* CIITA_25753668_ChIP-Seq_RAJI_Human1.02169729
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01578869
96* UTX_26944678_Chip-Seq_JUKART_Human1.00600909
97MAF_26560356_Chip-Seq_TH1_Human0.99762771
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99450616
99* TP53_22573176_ChIP-Seq_HFKS_Human0.99166783
100ERG_20517297_ChIP-Seq_VCAP_Human0.97923130
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94496998
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94049975
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93343934
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92324622
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92220728
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91758695
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91367515
108AR_20517297_ChIP-Seq_VCAP_Human0.90944737
109MYB_26560356_Chip-Seq_TH1_Human0.90437540
110MYB_26560356_Chip-Seq_TH2_Human0.90184207
111TAF15_26573619_Chip-Seq_HEK293_Human0.89789023
112CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89785571
113IGF1R_20145208_ChIP-Seq_DFB_Human0.89676976
114RNF2_27304074_Chip-Seq_NSC_Mouse0.89599589
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89084237
116* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88802035
117P300_19829295_ChIP-Seq_ESCs_Human0.88744812
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88427597
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88105756
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88105756
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88105756
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87932791
123VDR_24763502_ChIP-Seq_THP-1_Human0.87802070
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87606512
125FOXM1_23109430_ChIP-Seq_U2OS_Human0.87404971
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86547801
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85452577
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85162939
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84409686
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84390042
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82821261
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80992207
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80921333
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.80921333
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77626714
136GATA3_21878914_ChIP-Seq_MCF-7_Human0.76437859
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75930594
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75267074
139ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75080967
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74870714
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74532121
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74519982
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70756944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.91215182
2MP0004381_abnormal_hair_follicle3.06620692
3MP0003763_abnormal_thymus_physiology2.64653023
4MP0003136_yellow_coat_color2.59981683
5MP0005174_abnormal_tail_pigmentation2.30360593
6MP0001293_anophthalmia2.16636664
7MP0005671_abnormal_response_to2.10925992
8MP0003724_increased_susceptibility_to2.02403247
9MP0000685_abnormal_immune_system1.99561728
10MP0001835_abnormal_antigen_presentation1.99098946
11MP0001800_abnormal_humoral_immune1.93136241
12MP0004142_abnormal_muscle_tone1.93101478
13MP0002166_altered_tumor_susceptibility1.90348977
14MP0002009_preneoplasia1.84075204
15MP0005409_darkened_coat_color1.81396250
16MP0003315_abnormal_perineum_morphology1.77238570
17MP0003693_abnormal_embryo_hatching1.76861600
18MP0002148_abnormal_hypersensitivity_rea1.76138352
19MP0002095_abnormal_skin_pigmentation1.75920237
20MP0005377_hearing/vestibular/ear_phenot1.73247136
21MP0003878_abnormal_ear_physiology1.73247136
22MP0009333_abnormal_splenocyte_physiolog1.72709102
23MP0002653_abnormal_ependyma_morphology1.72456027
24MP0003941_abnormal_skin_development1.70774717
25MP0000631_abnormal_neuroendocrine_gland1.69407213
26MP0005075_abnormal_melanosome_morpholog1.68440167
27MP0002277_abnormal_respiratory_mucosa1.66382592
28MP0009785_altered_susceptibility_to1.66177914
29MP0004957_abnormal_blastocyst_morpholog1.64604615
30MP0005000_abnormal_immune_tolerance1.61930575
31MP0002420_abnormal_adaptive_immunity1.61568758
32MP0002132_abnormal_respiratory_system1.60097491
33MP0002452_abnormal_antigen_presenting1.58274039
34MP0001819_abnormal_immune_cell1.57955241
35MP0002723_abnormal_immune_serum1.57700309
36MP0002396_abnormal_hematopoietic_system1.55966207
37MP0002398_abnormal_bone_marrow1.54731845
38MP0002163_abnormal_gland_morphology1.50767414
39MP0005025_abnormal_response_to1.49876664
40MP0003786_premature_aging1.49404558
41MP0001485_abnormal_pinna_reflex1.49027197
42MP0008789_abnormal_olfactory_epithelium1.47890218
43MP0001529_abnormal_vocalization1.47642336
44MP0001790_abnormal_immune_system1.47597728
45MP0005387_immune_system_phenotype1.47597728
46MP0002006_tumorigenesis1.44765610
47MP0003880_abnormal_central_pattern1.44697085
48MP0000703_abnormal_thymus_morphology1.43126181
49MP0000490_abnormal_crypts_of1.41340951
50MP0002938_white_spotting1.41286291
51MP0002722_abnormal_immune_system1.38953573
52MP0003866_abnormal_defecation1.38273753
53MP0003011_delayed_dark_adaptation1.37757693
54MP0000372_irregular_coat_pigmentation1.37455729
55MP0002234_abnormal_pharynx_morphology1.36499508
56MP0000716_abnormal_immune_system1.36241139
57MP0002796_impaired_skin_barrier1.35236631
58MP0010155_abnormal_intestine_physiology1.35114051
59MP0006292_abnormal_olfactory_placode1.33226700
60MP0000465_gastrointestinal_hemorrhage1.32389004
61MP0002405_respiratory_system_inflammati1.31276431
62MP0000689_abnormal_spleen_morphology1.30429333
63MP0005084_abnormal_gallbladder_morpholo1.29997872
64MP0004885_abnormal_endolymph1.29568375
65MP0003890_abnormal_embryonic-extraembry1.28946944
66MP0001286_abnormal_eye_development1.28407120
67MP0004133_heterotaxia1.27166405
68MP0001873_stomach_inflammation1.21987879
69MP0002429_abnormal_blood_cell1.21591988
70MP0003077_abnormal_cell_cycle1.21207011
71MP0010094_abnormal_chromosome_stability1.21183697
72MP0008995_early_reproductive_senescence1.20580057
73MP0002254_reproductive_system_inflammat1.20538252
74MP0000537_abnormal_urethra_morphology1.20377196
75MP0002638_abnormal_pupillary_reflex1.19212893
76MP0003436_decreased_susceptibility_to1.15763287
77MP0001346_abnormal_lacrimal_gland1.15127192
78MP0002098_abnormal_vibrissa_morphology1.14848013
79MP0002697_abnormal_eye_size1.14345683
80MP0001853_heart_inflammation1.13053339
81MP0005499_abnormal_olfactory_system1.12527089
82MP0005394_taste/olfaction_phenotype1.12527089
83MP0001919_abnormal_reproductive_system1.12499853
84MP0004808_abnormal_hematopoietic_stem1.12370126
85MP0002102_abnormal_ear_morphology1.12307026
86MP0000613_abnormal_salivary_gland1.11966003
87MP0000026_abnormal_inner_ear1.11449674
88MP0008057_abnormal_DNA_replication1.10914124
89MP0001851_eye_inflammation1.10533771
90MP0005501_abnormal_skin_physiology1.08853674
91MP0000049_abnormal_middle_ear1.08817537
92MP0008058_abnormal_DNA_repair1.08076460
93MP0005551_abnormal_eye_electrophysiolog1.06606291
94MP0004742_abnormal_vestibular_system1.06451815
95MP0001879_abnormal_lymphatic_vessel1.05040019
96MP0003283_abnormal_digestive_organ1.03435804
97MP0008932_abnormal_embryonic_tissue1.02406896
98MP0008007_abnormal_cellular_replicative1.01658592
99MP0005379_endocrine/exocrine_gland_phen1.01335696
100MP0002249_abnormal_larynx_morphology0.99320472
101MP0002933_joint_inflammation0.98774944
102MP0005253_abnormal_eye_physiology0.97160585
103MP0000383_abnormal_hair_follicle0.94979550
104MP0001216_abnormal_epidermal_layer0.90948677
105MP0000762_abnormal_tongue_morphology0.90514343
106MP0003186_abnormal_redox_activity0.85166248
107MP0000778_abnormal_nervous_system0.84906422
108MP0008877_abnormal_DNA_methylation0.84006506
109MP0005391_vision/eye_phenotype0.83981536
110MP0001188_hyperpigmentation0.83499615
111MP0003938_abnormal_ear_development0.83423259
112MP0000566_synostosis0.82948481
113MP0002233_abnormal_nose_morphology0.80339723
114MP0002736_abnormal_nociception_after0.80315891
115MP0004947_skin_inflammation0.78929971
116MP0002177_abnormal_outer_ear0.78808925
117MP0010030_abnormal_orbit_morphology0.77812506
118MP0002822_catalepsy0.77683632
119MP0001986_abnormal_taste_sensitivity0.77565339
120MP0000858_altered_metastatic_potential0.76446091
121MP0002928_abnormal_bile_duct0.75210582
122MP0001984_abnormal_olfaction0.74944794
123MP0002419_abnormal_innate_immunity0.74600093
124MP0005195_abnormal_posterior_eye0.74528209
125MP0001845_abnormal_inflammatory_respons0.74465815
126MP0002060_abnormal_skin_morphology0.74420595
127MP0002210_abnormal_sex_determination0.72973668
128MP0008004_abnormal_stomach_pH0.72457629
129MP0002752_abnormal_somatic_nervous0.72074328
130MP0002019_abnormal_tumor_incidence0.71651902
131MP0003937_abnormal_limbs/digits/tail_de0.71133138
132MP0006276_abnormal_autonomic_nervous0.71122928
133MP0005464_abnormal_platelet_physiology0.71114587
134MP0002282_abnormal_trachea_morphology0.70973555
135MP0002751_abnormal_autonomic_nervous0.70754073
136MP0001324_abnormal_eye_pigmentation0.70212402
137MP0005408_hypopigmentation0.69454578
138MP0003111_abnormal_nucleus_morphology0.68642137
139MP0003567_abnormal_fetal_cardiomyocyte0.68446110
140MP0001663_abnormal_digestive_system0.68037015
141MP0003119_abnormal_digestive_system0.67957969
142MP0000377_abnormal_hair_follicle0.67456014
143MP0006072_abnormal_retinal_apoptosis0.67248807
144MP0001905_abnormal_dopamine_level0.66436024
145MP0001963_abnormal_hearing_physiology0.66425382
146MP0005423_abnormal_somatic_nervous0.64337311
147MP0009250_abnormal_appendicular_skeleto0.64048453
148MP0003638_abnormal_response/metabolism_0.62807704
149MP0005645_abnormal_hypothalamus_physiol0.62164363
150MP0001299_abnormal_eye_distance/0.62113686
151MP0008961_abnormal_basal_metabolism0.59157741
152MP0003718_maternal_effect0.58866317
153MP0000579_abnormal_nail_morphology0.58775690
154MP0005171_absent_coat_pigmentation0.58210608
155MP0001145_abnormal_male_reproductive0.58004353
156MP0005389_reproductive_system_phenotype0.57457947
157MP0004145_abnormal_muscle_electrophysio0.57228351
158MP0001968_abnormal_touch/_nociception0.56202643
159MP0000653_abnormal_sex_gland0.55273026
160MP0005646_abnormal_pituitary_gland0.53818207
161MP0002837_dystrophic_cardiac_calcinosis0.52354392
162MP0008872_abnormal_physiological_respon0.51418187
163MP0009053_abnormal_anal_canal0.50932813
164MP0003698_abnormal_male_reproductive0.49418352

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)9.33284288
2Abnormality of cells of the erythroid lineage (HP:0012130)9.25602915
3Abnormal number of erythroid precursors (HP:0012131)8.27434074
4Macrocytic anemia (HP:0001972)6.85502042
5Pallor (HP:0000980)6.27176107
6Septo-optic dysplasia (HP:0100842)5.14376066
7Abnormal hemoglobin (HP:0011902)4.38949568
8Aplasia/Hypoplasia of the sacrum (HP:0008517)4.13138699
9Increased hepatocellular lipid droplets (HP:0006565)3.80176294
10Congenital, generalized hypertrichosis (HP:0004540)3.74718809
11Thrombocytosis (HP:0001894)3.55248210
12Absent septum pellucidum (HP:0001331)3.39714055
1311 pairs of ribs (HP:0000878)3.31109340
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25298635
15Maternal diabetes (HP:0009800)3.20640321
16Renal Fanconi syndrome (HP:0001994)3.19582442
17Lipid accumulation in hepatocytes (HP:0006561)3.17527932
18Mitochondrial inheritance (HP:0001427)3.14427111
19Abnormality of the axillary hair (HP:0100134)3.10783546
20Abnormality of secondary sexual hair (HP:0009888)3.10783546
21Exertional dyspnea (HP:0002875)3.04853542
22Colon cancer (HP:0003003)3.02779549
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.97084675
24Depressed nasal ridge (HP:0000457)2.93905217
25Hepatocellular necrosis (HP:0001404)2.91028219
26IgM deficiency (HP:0002850)2.89891136
27Abnormality of the septum pellucidum (HP:0007375)2.85593485
28Cerebral edema (HP:0002181)2.85444396
29Aplastic anemia (HP:0001915)2.80920570
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80469026
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80469026
32Woolly hair (HP:0002224)2.74659156
33Concave nail (HP:0001598)2.69909733
34Acute necrotizing encephalopathy (HP:0006965)2.69013399
35Migraine (HP:0002076)2.63122769
36Partial duplication of thumb phalanx (HP:0009944)2.57204228
37Abnormality of reticulocytes (HP:0004312)2.57007970
383-Methylglutaconic aciduria (HP:0003535)2.56261265
39Increased intramyocellular lipid droplets (HP:0012240)2.55975934
40Pancreatic cysts (HP:0001737)2.55541167
41Optic disc pallor (HP:0000543)2.53461370
42Optic nerve hypoplasia (HP:0000609)2.50241852
43Respiratory difficulties (HP:0002880)2.49630030
44Absent thumb (HP:0009777)2.49473133
45Asplenia (HP:0001746)2.45938753
46Stenosis of the external auditory canal (HP:0000402)2.44712705
47Partial duplication of the phalanx of hand (HP:0009999)2.42493735
48Parakeratosis (HP:0001036)2.39718986
49Esophageal atresia (HP:0002032)2.39457469
50Thick lower lip vermilion (HP:0000179)2.36884063
51Recurrent bronchitis (HP:0002837)2.36818822
52Increased CSF lactate (HP:0002490)2.36413779
53Elevated erythrocyte sedimentation rate (HP:0003565)2.35300907
54Pancreatic fibrosis (HP:0100732)2.33122082
55Progressive macrocephaly (HP:0004481)2.30361579
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29725886
57Hepatic necrosis (HP:0002605)2.28984102
58Triphalangeal thumb (HP:0001199)2.27878170
59Abnormal mitochondria in muscle tissue (HP:0008316)2.27843234
60Abnormality of midbrain morphology (HP:0002418)2.26848834
61Molar tooth sign on MRI (HP:0002419)2.26848834
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.23987420
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20155683
64Rib fusion (HP:0000902)2.18321354
65Panhypogammaglobulinemia (HP:0003139)2.17646823
66Leukodystrophy (HP:0002415)2.17289497
67True hermaphroditism (HP:0010459)2.16716365
68Hypoplasia of the radius (HP:0002984)2.16642109
69Nasolacrimal duct obstruction (HP:0000579)2.15995812
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14732644
71Chronic otitis media (HP:0000389)2.12283967
72Agammaglobulinemia (HP:0004432)2.11431899
73Nephronophthisis (HP:0000090)2.08224099
74IgG deficiency (HP:0004315)2.07880652
75Fragile nails (HP:0001808)2.07005245
76Abnormality of the labia minora (HP:0012880)2.02630012
77Increased muscle lipid content (HP:0009058)2.02545873
78Bilateral microphthalmos (HP:0007633)2.01738600
79Ridged nail (HP:0001807)1.98671564
80Aplasia/hypoplasia of the uterus (HP:0008684)1.97370417
81Abnormality of the lacrimal duct (HP:0011481)1.95951256
82Abnormal ciliary motility (HP:0012262)1.95864516
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94675596
84Respiratory failure (HP:0002878)1.94232165
85Hypotrichosis (HP:0001006)1.94041950
86Prolonged bleeding time (HP:0003010)1.93082885
87Abnormality of the parietal bone (HP:0002696)1.92652277
88Abnormality of B cell number (HP:0010975)1.91346478
89B lymphocytopenia (HP:0010976)1.91346478
90Severe combined immunodeficiency (HP:0004430)1.91116842
91Congenital stationary night blindness (HP:0007642)1.90829471
92Abnormality of urine glucose concentration (HP:0011016)1.89436267
93Glycosuria (HP:0003076)1.89436267
94Lactic acidosis (HP:0003128)1.89321505
95Sparse eyelashes (HP:0000653)1.88940379
96Abnormal respiratory motile cilium physiology (HP:0012261)1.88068638
97Abnormality of renal resorption (HP:0011038)1.87561438
98Anophthalmia (HP:0000528)1.85467589
99Acute encephalopathy (HP:0006846)1.85254962
100T lymphocytopenia (HP:0005403)1.85135009
101Medial flaring of the eyebrow (HP:0010747)1.83923777
102Autoimmune hemolytic anemia (HP:0001890)1.83480198
103Abnormality of T cells (HP:0002843)1.83281270
104Oral leukoplakia (HP:0002745)1.82878636
105Gastrointestinal atresia (HP:0002589)1.82638333
106Supernumerary bones of the axial skeleton (HP:0009144)1.82086875
107Thyroiditis (HP:0100646)1.81585541
108Muscle fiber atrophy (HP:0100295)1.81109868
109Cleft eyelid (HP:0000625)1.79332945
110Pancytopenia (HP:0001876)1.79238109
111Sclerocornea (HP:0000647)1.78433530
112Abnormality of T cell number (HP:0011839)1.77670413
113Abnormal number of incisors (HP:0011064)1.77525233
114Missing ribs (HP:0000921)1.77456098
115Recurrent sinusitis (HP:0011108)1.77217697
116Hypoproteinemia (HP:0003075)1.76785341
117Poikiloderma (HP:0001029)1.76597613
118Sparse scalp hair (HP:0002209)1.75430759
119Abnormality of the nasolacrimal system (HP:0000614)1.74755467
120Trismus (HP:0000211)1.74118076
121Synostosis involving the elbow (HP:0003938)1.72934432
122Humeroradial synostosis (HP:0003041)1.72934432
123Abnormal respiratory epithelium morphology (HP:0012253)1.70235700
124Abnormal respiratory motile cilium morphology (HP:0005938)1.70235700
125Abnormality of the pons (HP:0007361)1.69857415
126Amniotic constriction ring (HP:0009775)1.69028874
127Abnormality of placental membranes (HP:0011409)1.69028874
128Exercise intolerance (HP:0003546)1.68992321
129Supernumerary ribs (HP:0005815)1.68861412
130Abnormality of the renal medulla (HP:0100957)1.68314968
131Chronic sinusitis (HP:0011109)1.68289009
132Lymphoma (HP:0002665)1.67676275
133Abnormality of T cell physiology (HP:0011840)1.67593242
134Abnormality of the middle phalanges of the toes (HP:0010183)1.67141913
135Myokymia (HP:0002411)1.66840630
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.66300947
137Seborrheic dermatitis (HP:0001051)1.65653503
138Rough bone trabeculation (HP:0100670)1.64976109
139Duplication of thumb phalanx (HP:0009942)1.64940274
140Type I transferrin isoform profile (HP:0003642)1.64666582
141Hypoplasia of the pons (HP:0012110)1.63855036
142Abnormal urine phosphate concentration (HP:0012599)1.63445426
143Type II lissencephaly (HP:0007260)1.62487964
144Increased serum lactate (HP:0002151)1.61870878
145Hyperphosphaturia (HP:0003109)1.60337502
146Dry hair (HP:0011359)1.60003832
147Forearm undergrowth (HP:0009821)1.59162481
148Anhidrosis (HP:0000970)1.59079149
149Meningitis (HP:0001287)1.58835162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.54999189
2TLK15.08486445
3NME24.65794883
4SRPK13.01484208
5ZAK2.96813257
6MAP4K12.67833543
7TAF12.63405363
8CDC72.48793784
9STK162.46190538
10CDK192.31559810
11LRRK22.30433812
12MST42.23610222
13VRK12.10399710
14FGFR22.07988305
15TGFBR12.06661887
16MUSK2.03198560
17RPS6KB22.02476388
18TXK1.96692584
19BLK1.92433041
20BUB11.90689506
21TEC1.67630880
22DYRK31.65565662
23EIF2AK11.65457707
24TAOK31.61495387
25BTK1.58686386
26WEE11.55412786
27NME11.53980490
28BCKDK1.53349324
29KDR1.52329826
30WNK31.52229505
31MKNK21.40981333
32MKNK11.39393111
33PIM21.35765779
34NLK1.34446208
35IKBKB1.30699326
36IKBKE1.27855514
37PASK1.24547988
38IRAK41.24219200
39MAP3K121.19005708
40WNK41.18282903
41EPHA41.11583016
42IRAK31.10502552
43INSRR1.09851669
44KIT1.07487007
45TYK21.05974553
46TGFBR21.04658893
47SYK1.02613560
48ZAP701.01909275
49EIF2AK31.01026871
50LCK1.00952696
51PNCK1.00117944
52NEK20.99523667
53ILK0.98490865
54MAPKAPK50.96793627
55EEF2K0.95846227
56RPS6KA50.95395434
57RPS6KA40.93812676
58AURKB0.92248893
59JAK30.90964483
60STK100.89420064
61MAPK150.88923129
62TESK20.84670129
63TBK10.84347068
64LYN0.84171032
65CDK70.83129851
66ITK0.81939369
67MYLK0.80303747
68MAP3K110.80041675
69BMPR1B0.77968905
70IRAK10.77538411
71GRK60.77464124
72PIM10.76803988
73BRSK20.76791584
74TNIK0.76598332
75TYRO30.76197576
76PIK3CG0.74432655
77GRK10.74245514
78NUAK10.73770089
79MAP2K60.73466277
80GRK70.71865744
81PBK0.71463706
82PLK30.71045313
83MAPKAPK30.70864289
84MAP3K30.70202374
85ACVR1B0.70064487
86EPHB20.67977357
87FLT30.67517958
88DAPK30.66885147
89CHEK20.65839779
90CSNK2A20.65783116
91CDK80.65782831
92EIF2AK20.63500170
93PRKCQ0.62609680
94PRKD20.61821826
95MST1R0.60547762
96HIPK20.60418597
97MAP3K40.60253416
98IRAK20.58932114
99ADRBK20.58835079
100CDK90.58697055
101FGFR10.57968837
102FES0.57819541
103MAP2K20.57507605
104PLK40.57084449
105MARK30.55248615
106TIE10.54820500
107CSNK2A10.54525728
108MAP4K20.53680685
109CASK0.50643837
110MATK0.50110504
111PINK10.49740337
112MAPK40.47618333
113YES10.46738871
114UHMK10.45894543
115NTRK20.45175405
116ADRBK10.43719180
117PRKG20.43098293
118ATR0.42953726
119TTK0.42944881
120STK240.42758374
121CLK10.42467654
122AURKA0.41868077
123STK40.41541742
124PRKCG0.41369400
125PIK3CA0.41293840
126CDK40.40972796
127TNK20.40198614
128HCK0.39929734
129PLK10.36860684
130DYRK20.36855919
131MAP3K100.36658059
132DYRK1B0.36020553
133MAP2K30.35766404
134PRKACA0.35294938
135CDK30.34967543
136OXSR10.34584707
137CAMK10.34220116
138CHUK0.34156551
139CSNK1G30.33505369
140DYRK1A0.33483890
141OBSCN0.33038831

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.15565313
2RNA polymerase_Homo sapiens_hsa030203.04139368
3Oxidative phosphorylation_Homo sapiens_hsa001902.53904817
4Spliceosome_Homo sapiens_hsa030402.50265175
5Proteasome_Homo sapiens_hsa030502.47679890
6DNA replication_Homo sapiens_hsa030302.40942305
7Protein export_Homo sapiens_hsa030602.40765640
8Parkinsons disease_Homo sapiens_hsa050122.29871441
9Primary immunodeficiency_Homo sapiens_hsa053402.28002490
10Mismatch repair_Homo sapiens_hsa034302.21511132
11Homologous recombination_Homo sapiens_hsa034402.04529845
12Pyrimidine metabolism_Homo sapiens_hsa002401.84695168
13Nucleotide excision repair_Homo sapiens_hsa034201.83159624
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82434581
15Huntingtons disease_Homo sapiens_hsa050161.76442121
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71966519
17Alzheimers disease_Homo sapiens_hsa050101.66749848
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65405953
19Base excision repair_Homo sapiens_hsa034101.42178032
20Fanconi anemia pathway_Homo sapiens_hsa034601.37870845
21RNA degradation_Homo sapiens_hsa030181.32200455
22Non-homologous end-joining_Homo sapiens_hsa034501.28169035
23Hematopoietic cell lineage_Homo sapiens_hsa046401.26934815
24RNA transport_Homo sapiens_hsa030131.21432738
25Basal transcription factors_Homo sapiens_hsa030221.20049869
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.15613659
27Antigen processing and presentation_Homo sapiens_hsa046121.09138580
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06114818
29Systemic lupus erythematosus_Homo sapiens_hsa053221.02797947
30Nitrogen metabolism_Homo sapiens_hsa009101.02079203
31NF-kappa B signaling pathway_Homo sapiens_hsa040640.93365419
32Purine metabolism_Homo sapiens_hsa002300.91464067
33Allograft rejection_Homo sapiens_hsa053300.91049719
34Graft-versus-host disease_Homo sapiens_hsa053320.89923512
35Herpes simplex infection_Homo sapiens_hsa051680.89333900
36p53 signaling pathway_Homo sapiens_hsa041150.85066989
37T cell receptor signaling pathway_Homo sapiens_hsa046600.84719770
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.84015786
39B cell receptor signaling pathway_Homo sapiens_hsa046620.83568645
40Measles_Homo sapiens_hsa051620.82317075
41Epstein-Barr virus infection_Homo sapiens_hsa051690.82126163
42Sulfur relay system_Homo sapiens_hsa041220.80470161
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80350661
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78542243
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77618181
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75240944
47Vitamin digestion and absorption_Homo sapiens_hsa049770.73257611
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73085099
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72125711
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72075091
51Autoimmune thyroid disease_Homo sapiens_hsa053200.70066483
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.69405845
53Asthma_Homo sapiens_hsa053100.68500669
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68311505
55Cell cycle_Homo sapiens_hsa041100.67406878
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67059082
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65505996
58Type I diabetes mellitus_Homo sapiens_hsa049400.64054987
59Arachidonic acid metabolism_Homo sapiens_hsa005900.63110748
60Cardiac muscle contraction_Homo sapiens_hsa042600.62821219
61Chemical carcinogenesis_Homo sapiens_hsa052040.62316673
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62135088
63One carbon pool by folate_Homo sapiens_hsa006700.61878270
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58895211
65mRNA surveillance pathway_Homo sapiens_hsa030150.56728245
66Basal cell carcinoma_Homo sapiens_hsa052170.55572061
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55126705
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.54384199
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54323648
70Metabolic pathways_Homo sapiens_hsa011000.53080498
71HTLV-I infection_Homo sapiens_hsa051660.52323797
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49960427
73Retinol metabolism_Homo sapiens_hsa008300.48428317
74Leishmaniasis_Homo sapiens_hsa051400.47634619
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47079622
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46832886
77Malaria_Homo sapiens_hsa051440.46008227
78Nicotine addiction_Homo sapiens_hsa050330.45314843
79Alcoholism_Homo sapiens_hsa050340.43665222
80Caffeine metabolism_Homo sapiens_hsa002320.42558204
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.42389727
82Sphingolipid metabolism_Homo sapiens_hsa006000.41276555
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40902703
84Folate biosynthesis_Homo sapiens_hsa007900.40529705
85Viral carcinogenesis_Homo sapiens_hsa052030.39412956
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38900715
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38237282
88Osteoclast differentiation_Homo sapiens_hsa043800.37691786
89Olfactory transduction_Homo sapiens_hsa047400.37042686
90Platelet activation_Homo sapiens_hsa046110.36776597
91Taste transduction_Homo sapiens_hsa047420.35715165
92Apoptosis_Homo sapiens_hsa042100.34772493
93Peroxisome_Homo sapiens_hsa041460.34386536
94Acute myeloid leukemia_Homo sapiens_hsa052210.34009173
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33205107
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32809477
97Rheumatoid arthritis_Homo sapiens_hsa053230.32764273
98Other glycan degradation_Homo sapiens_hsa005110.32321619
99Pertussis_Homo sapiens_hsa051330.32278606
100Tryptophan metabolism_Homo sapiens_hsa003800.32240552
101Hepatitis B_Homo sapiens_hsa051610.31658704
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31482423
103Notch signaling pathway_Homo sapiens_hsa043300.30810636
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30100056
105Fat digestion and absorption_Homo sapiens_hsa049750.29968815
106Pathways in cancer_Homo sapiens_hsa052000.29460524
107Glutathione metabolism_Homo sapiens_hsa004800.29159695
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.28857048
109Shigellosis_Homo sapiens_hsa051310.26251228
110Hedgehog signaling pathway_Homo sapiens_hsa043400.25351290
111Small cell lung cancer_Homo sapiens_hsa052220.24957829
112Linoleic acid metabolism_Homo sapiens_hsa005910.24486498
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24481672
114Regulation of autophagy_Homo sapiens_hsa041400.23839925
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23722969
116Ether lipid metabolism_Homo sapiens_hsa005650.23712409
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23652982
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.23427429
119Butanoate metabolism_Homo sapiens_hsa006500.22930970
120Wnt signaling pathway_Homo sapiens_hsa043100.22621729
121Tyrosine metabolism_Homo sapiens_hsa003500.22197260
122Legionellosis_Homo sapiens_hsa051340.20155104
123Influenza A_Homo sapiens_hsa051640.19640788
124Toxoplasmosis_Homo sapiens_hsa051450.19612658
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19341032
126Collecting duct acid secretion_Homo sapiens_hsa049660.19123477
127Phototransduction_Homo sapiens_hsa047440.18873318
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18586802
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18502666
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18138007
131Selenocompound metabolism_Homo sapiens_hsa004500.18055044
132Chemokine signaling pathway_Homo sapiens_hsa040620.17482485
133TGF-beta signaling pathway_Homo sapiens_hsa043500.16623644
134Propanoate metabolism_Homo sapiens_hsa006400.16467720
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15020878
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12296518
137Pyruvate metabolism_Homo sapiens_hsa006200.11591773
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11090646
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08994175
140Mineral absorption_Homo sapiens_hsa049780.08736216
141Serotonergic synapse_Homo sapiens_hsa047260.07809558
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.07726527

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