ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.27879018
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.90680910
3	DNA deamination (GO:0045006)	5.88330372
4	ATP synthesis coupled proton transport (GO:0015986)	5.80492895
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.80492895
6	viral transcription (GO:0019083)	5.59340213
7	translational termination (GO:0006415)	5.39859126
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.97219696
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.92970758
10	cytidine metabolic process (GO:0046087)	4.90567732
11	cytidine catabolic process (GO:0006216)	4.90567732
12	cytidine deamination (GO:0009972)	4.90567732
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.85743284
14	protein neddylation (GO:0045116)	4.81967934
15	protein targeting to ER (GO:0045047)	4.79003614
16	cotranslational protein targeting to membrane (GO:0006613)	4.78957198
17	respiratory electron transport chain (GO:0022904)	4.73743325
18	electron transport chain (GO:0022900)	4.73204818
19	translational elongation (GO:0006414)	4.68779195
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.56649638
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.55448357
22	protein localization to endoplasmic reticulum (GO:0070972)	4.51537229
23	maturation of SSU-rRNA (GO:0030490)	4.43079233
24	ribosomal small subunit biogenesis (GO:0042274)	4.33595324
25	cellular protein complex disassembly (GO:0043624)	4.03235063
26	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.01088091
27	viral life cycle (GO:0019058)	3.99187174
28	protein complex biogenesis (GO:0070271)	3.90544785
29	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.78660660
30	ribosomal large subunit biogenesis (GO:0042273)	3.66011736
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.58430240
32	behavioral response to nicotine (GO:0035095)	3.56769345
33	translational initiation (GO:0006413)	3.54378578
34	chaperone-mediated protein transport (GO:0072321)	3.48125875
35	hydrogen ion transmembrane transport (GO:1902600)	3.43105083
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38666216
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37993426
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37993426
39	NADH dehydrogenase complex assembly (GO:0010257)	3.37993426
40	sequestering of actin monomers (GO:0042989)	3.37462951
41	mannosylation (GO:0097502)	3.32556341
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.27884483
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.27884483
44	translation (GO:0006412)	3.27231092
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25843309
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.24207992
47	ATP biosynthetic process (GO:0006754)	3.23549965
48	proton transport (GO:0015992)	3.22975872
49	protein complex disassembly (GO:0043241)	3.20739134
50	hydrogen transport (GO:0006818)	3.17176489
51	kynurenine metabolic process (GO:0070189)	3.12786411
52	protein targeting to membrane (GO:0006612)	3.10304793
53	macromolecular complex disassembly (GO:0032984)	3.08969638
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.05195616
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.04963929
56	tryptophan catabolic process (GO:0006569)	3.04075729
57	indole-containing compound catabolic process (GO:0042436)	3.04075729
58	indolalkylamine catabolic process (GO:0046218)	3.04075729
59	positive T cell selection (GO:0043368)	3.02901004
60	proteasome assembly (GO:0043248)	2.94965496
61	cytochrome complex assembly (GO:0017004)	2.91162067
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.88408084
63	termination of RNA polymerase III transcription (GO:0006386)	2.88408084
64	positive regulation of calcium-mediated signaling (GO:0050850)	2.86341251
65	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.81312263
66	positive thymic T cell selection (GO:0045059)	2.76949788
67	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.73380552
68	protein-cofactor linkage (GO:0018065)	2.70804435
69	tryptophan metabolic process (GO:0006568)	2.70361792
70	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.69540931
71	preassembly of GPI anchor in ER membrane (GO:0016254)	2.69483060
72	regulation of cellular amino acid metabolic process (GO:0006521)	2.68653816
73	indolalkylamine metabolic process (GO:0006586)	2.68524400
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.67959194
75	respiratory chain complex IV assembly (GO:0008535)	2.67345077
76	mRNA catabolic process (GO:0006402)	2.65947479
77	response to interferon-beta (GO:0035456)	2.64645473
78	negative T cell selection (GO:0043383)	2.64198339
79	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.62632618
80	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.62632618
81	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.62632618
82	base-excision repair, AP site formation (GO:0006285)	2.61353941
83	sulfation (GO:0051923)	2.60778092
84	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.60720317
85	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.60720317
86	GPI anchor metabolic process (GO:0006505)	2.60421577
87	positive regulation of tolerance induction (GO:0002645)	2.60089760
88	iron-sulfur cluster assembly (GO:0016226)	2.59996755
89	metallo-sulfur cluster assembly (GO:0031163)	2.59996755
90	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.59542429
91	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.56640614
92	GPI anchor biosynthetic process (GO:0006506)	2.54977423
93	cellular component biogenesis (GO:0044085)	2.54617335
94	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54596935
95	mast cell activation (GO:0045576)	2.51716847
96	T cell migration (GO:0072678)	2.51234934
97	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.50279794
98	negative regulation of mast cell activation (GO:0033004)	2.50011138
99	cell wall macromolecule metabolic process (GO:0044036)	2.49018729
100	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.48227688

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.46144992
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32352994
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.08207767
4	VDR_22108803_ChIP-Seq_LS180_Human	2.87348486
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.71198825
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66791550
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58806685
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.47747368
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.47097659
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.26835674
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.18239715
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15533412
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13499936
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.05747362
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.00659546
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.98983561
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95108776
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.94006903
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89842534
20	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.88740451
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83398902
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.82294004
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.77067616
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.72406716
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71532196
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.67441460
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64514371
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64316926
29	EWS_26573619_Chip-Seq_HEK293_Human	1.60952245
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59079984
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58354379
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57307319
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.56881411
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55528647
35	FUS_26573619_Chip-Seq_HEK293_Human	1.51661924
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50260571
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50260571
38	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.49109908
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48571772
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47872021
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46187260
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.43349187
43	AR_20517297_ChIP-Seq_VCAP_Human	1.43053468
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.42899592
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42898254
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39525354
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37865156
48	P300_19829295_ChIP-Seq_ESCs_Human	1.37710178
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36236706
50	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.36169458
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.34156152
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33595626
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31657036
54	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29017159
55	GATA3_26560356_Chip-Seq_TH2_Human	1.28852181
56	NCOR_22424771_ChIP-Seq_293T_Human	1.28601693
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26964653
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26964653
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26280654
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25590596
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22530295
62	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20768723
63	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.20373107
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16135053
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15487802
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14990140
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14294062
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.13734502
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13667006
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13587845
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.13542010
72	MYB_26560356_Chip-Seq_TH2_Human	1.13514905
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12816650
74	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12771004
75	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11186328
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11086310
77	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10577151
78	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10507736
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10374162
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09859096
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.09859096
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.08693623
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08555436
84	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07981994
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07977619
86	GATA3_27048872_Chip-Seq_THYMUS_Human	1.07759468
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07609382
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05899302
89	RUNX_20019798_ChIP-Seq_JUKART_Human	1.05813358
90	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.05574496
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04568031
92	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03741820
93	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02516664
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01455527
95	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99924181
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.99879703
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99605961
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.98821640
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97554336
100	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96994032

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.43087515
2	MP0005671_abnormal_response_to	4.01320896
3	MP0003646_muscle_fatigue	2.44586289
4	MP0002102_abnormal_ear_morphology	2.36911792
5	MP0000372_irregular_coat_pigmentation	2.26191813
6	MP0002653_abnormal_ependyma_morphology	2.22002996
7	MP0008877_abnormal_DNA_methylation	2.21586408
8	MP0001835_abnormal_antigen_presentation	2.19842027
9	MP0002163_abnormal_gland_morphology	2.19700948
10	MP0006072_abnormal_retinal_apoptosis	2.17592012
11	MP0006292_abnormal_olfactory_placode	2.10054485
12	MP0002837_dystrophic_cardiac_calcinosis	2.06997643
13	MP0008872_abnormal_physiological_respon	2.01211128
14	MP0005646_abnormal_pituitary_gland	1.96364257
15	MP0001873_stomach_inflammation	1.96196734
16	MP0009785_altered_susceptibility_to	1.95311798
17	MP0003878_abnormal_ear_physiology	1.90048493
18	MP0005377_hearing/vestibular/ear_phenot	1.90048493
19	MP0004142_abnormal_muscle_tone	1.77670925
20	MP0003880_abnormal_central_pattern	1.76948602
21	MP0002736_abnormal_nociception_after	1.66740028
22	MP0002277_abnormal_respiratory_mucosa	1.61673025
23	MP0003806_abnormal_nucleotide_metabolis	1.59936151
24	MP0005551_abnormal_eye_electrophysiolog	1.58184544
25	MP0003195_calcinosis	1.57877978
26	MP0002095_abnormal_skin_pigmentation	1.55607438
27	MP0002166_altered_tumor_susceptibility	1.47138197
28	MP0005645_abnormal_hypothalamus_physiol	1.45028218
29	MP0001968_abnormal_touch/_nociception	1.43798143
30	MP0001800_abnormal_humoral_immune	1.43769673
31	MP0005075_abnormal_melanosome_morpholog	1.42232569
32	MP0001905_abnormal_dopamine_level	1.41761874
33	MP0003763_abnormal_thymus_physiology	1.40348359
34	MP0004145_abnormal_muscle_electrophysio	1.37189487
35	MP0003011_delayed_dark_adaptation	1.36907406
36	MP0005379_endocrine/exocrine_gland_phen	1.36833270
37	MP0005174_abnormal_tail_pigmentation	1.36480902
38	MP0000685_abnormal_immune_system	1.34593571
39	MP0002876_abnormal_thyroid_physiology	1.34453425
40	MP0002148_abnormal_hypersensitivity_rea	1.34324046
41	MP0004885_abnormal_endolymph	1.32393356
42	MP0008875_abnormal_xenobiotic_pharmacok	1.30988460
43	MP0005000_abnormal_immune_tolerance	1.26220339
44	MP0003136_yellow_coat_color	1.25699574
45	MP0005387_immune_system_phenotype	1.23985029
46	MP0001790_abnormal_immune_system	1.23985029
47	MP0001485_abnormal_pinna_reflex	1.20997898
48	MP0008995_early_reproductive_senescence	1.20857051
49	MP0004147_increased_porphyrin_level	1.20854507
50	MP0002160_abnormal_reproductive_system	1.20586217
51	MP0006036_abnormal_mitochondrial_physio	1.20409776
52	MP0003787_abnormal_imprinting	1.17735873
53	MP0002638_abnormal_pupillary_reflex	1.17184419
54	MP0002420_abnormal_adaptive_immunity	1.17082048
55	MP0001819_abnormal_immune_cell	1.15463594
56	MP0005253_abnormal_eye_physiology	1.15375549
57	MP0005389_reproductive_system_phenotype	1.14605867
58	MP0005025_abnormal_response_to	1.13227553
59	MP0002723_abnormal_immune_serum	1.13183025
60	MP0002272_abnormal_nervous_system	1.13060886
61	MP0002006_tumorigenesis	1.10981398
62	MP0010386_abnormal_urinary_bladder	1.08885460
63	MP0004742_abnormal_vestibular_system	1.07201715
64	MP0002938_white_spotting	1.06479247
65	MP0009764_decreased_sensitivity_to	1.06019195
66	MP0009333_abnormal_splenocyte_physiolog	1.05709655
67	MP0006276_abnormal_autonomic_nervous	1.05193063
68	MP0001919_abnormal_reproductive_system	1.02042219
69	MP0002138_abnormal_hepatobiliary_system	1.01229196
70	MP0005084_abnormal_gallbladder_morpholo	1.00740695
71	MP0009745_abnormal_behavioral_response	0.97364119
72	MP0000631_abnormal_neuroendocrine_gland	0.97055267
73	MP0000716_abnormal_immune_system	0.96602942
74	MP0002452_abnormal_antigen_presenting	0.96540549
75	MP0003866_abnormal_defecation	0.96154911
76	MP0005410_abnormal_fertilization	0.95907471
77	MP0001501_abnormal_sleep_pattern	0.94576663
78	MP0002693_abnormal_pancreas_physiology	0.89393849
79	MP0001440_abnormal_grooming_behavior	0.86975160
80	MP0002928_abnormal_bile_duct	0.86877993
81	MP0009046_muscle_twitch	0.85581605
82	MP0002398_abnormal_bone_marrow	0.84371703
83	MP0001970_abnormal_pain_threshold	0.83892136
84	MP0003252_abnormal_bile_duct	0.83275347
85	MP0001663_abnormal_digestive_system	0.81943101
86	MP0001765_abnormal_ion_homeostasis	0.81905337
87	MP0001986_abnormal_taste_sensitivity	0.79924648
88	MP0005636_abnormal_mineral_homeostasis	0.79434697
89	MP0003567_abnormal_fetal_cardiomyocyte	0.78879514
90	MP0003638_abnormal_response/metabolism_	0.75865791
91	MP0003137_abnormal_impulse_conducting	0.74281512
92	MP0000026_abnormal_inner_ear	0.73835601
93	MP0001845_abnormal_inflammatory_respons	0.73383654
94	MP0002132_abnormal_respiratory_system	0.73087706
95	MP0003283_abnormal_digestive_organ	0.72206395
96	MP0001188_hyperpigmentation	0.71163103
97	MP0004019_abnormal_vitamin_homeostasis	0.69002709
98	MP0006082_CNS_inflammation	0.67870138
99	MP0001764_abnormal_homeostasis	0.66830682
100	MP0002429_abnormal_blood_cell	0.66600640

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.12366580
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.53987805
3	Mitochondrial inheritance (HP:0001427)	4.53675844
4	Progressive macrocephaly (HP:0004481)	4.31973186
5	Acute encephalopathy (HP:0006846)	4.22547726
6	Hepatocellular necrosis (HP:0001404)	3.97479522
7	Increased CSF lactate (HP:0002490)	3.91763172
8	3-Methylglutaconic aciduria (HP:0003535)	3.71438121
9	Aplastic anemia (HP:0001915)	3.65710216
10	Congenital stationary night blindness (HP:0007642)	3.55216846
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.52814471
12	Reticulocytopenia (HP:0001896)	3.52010944
13	Increased hepatocellular lipid droplets (HP:0006565)	3.49014540
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.39784245
15	Hepatic necrosis (HP:0002605)	3.37752604
16	Abnormality of midbrain morphology (HP:0002418)	3.31320672
17	Molar tooth sign on MRI (HP:0002419)	3.31320672
18	Pancreatic cysts (HP:0001737)	3.28746610
19	Lipid accumulation in hepatocytes (HP:0006561)	3.21697273
20	Pancreatic fibrosis (HP:0100732)	3.10895903
21	Cerebral edema (HP:0002181)	3.09116348
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.05957087
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.05957087
24	Optic disc pallor (HP:0000543)	3.01656106
25	True hermaphroditism (HP:0010459)	3.00875983
26	Macrocytic anemia (HP:0001972)	2.98272892
27	Increased intramyocellular lipid droplets (HP:0012240)	2.97956030
28	Renal Fanconi syndrome (HP:0001994)	2.91917490
29	IgG deficiency (HP:0004315)	2.91546721
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.91033456
31	Elevated erythrocyte sedimentation rate (HP:0003565)	2.79917908
32	Abnormal number of erythroid precursors (HP:0012131)	2.76037840
33	Leukodystrophy (HP:0002415)	2.72288720
34	Congenital, generalized hypertrichosis (HP:0004540)	2.59270892
35	Pallor (HP:0000980)	2.59139053
36	T lymphocytopenia (HP:0005403)	2.55637996
37	Nephronophthisis (HP:0000090)	2.55503417
38	Abnormality of T cell number (HP:0011839)	2.55250214
39	Abnormality of B cell number (HP:0010975)	2.54147451
40	Increased IgM level (HP:0003496)	2.52504259
41	Increased muscle lipid content (HP:0009058)	2.47398630
42	Severe combined immunodeficiency (HP:0004430)	2.46965927
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45614283
44	Abolished electroretinogram (ERG) (HP:0000550)	2.42700777
45	Abnormality of T cells (HP:0002843)	2.40273278
46	Exertional dyspnea (HP:0002875)	2.39726597
47	Type II lissencephaly (HP:0007260)	2.39512774
48	Respiratory failure (HP:0002878)	2.38790456
49	Hypoproteinemia (HP:0003075)	2.36625619
50	Attenuation of retinal blood vessels (HP:0007843)	2.31531335
51	Stomatitis (HP:0010280)	2.29760479
52	Increased serum lactate (HP:0002151)	2.28958393
53	Methylmalonic acidemia (HP:0002912)	2.27249849
54	Abnormality of renal resorption (HP:0011038)	2.27036377
55	Lactic acidosis (HP:0003128)	2.24842696
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.20126561
57	Stenosis of the external auditory canal (HP:0000402)	2.19632863
58	Colon cancer (HP:0003003)	2.18071649
59	Absent thumb (HP:0009777)	2.17259176
60	Abnormality of the renal cortex (HP:0011035)	2.16272822
61	Medial flaring of the eyebrow (HP:0010747)	2.12030801
62	Abnormal hemoglobin (HP:0011902)	2.09814370
63	Global brain atrophy (HP:0002283)	2.07802795
64	Decreased central vision (HP:0007663)	2.05831940
65	B lymphocytopenia (HP:0010976)	2.03933375
66	Sclerocornea (HP:0000647)	2.03129752
67	Panhypogammaglobulinemia (HP:0003139)	2.02031305
68	Lethargy (HP:0001254)	2.01966222
69	Abnormality of the renal medulla (HP:0100957)	1.97984693
70	Autoimmune hemolytic anemia (HP:0001890)	1.92487263
71	Respiratory difficulties (HP:0002880)	1.92114477
72	Methylmalonic aciduria (HP:0012120)	1.91788418
73	Constricted visual fields (HP:0001133)	1.91198963
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90620465
75	Cystic liver disease (HP:0006706)	1.89201851
76	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.88813708
77	Pancytopenia (HP:0001876)	1.87891789
78	Thyroiditis (HP:0100646)	1.85532334
79	Exercise intolerance (HP:0003546)	1.85358807
80	Abnormal drinking behavior (HP:0030082)	1.84410878
81	Polydipsia (HP:0001959)	1.84410878
82	Pendular nystagmus (HP:0012043)	1.84239764
83	Combined immunodeficiency (HP:0005387)	1.83877729
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82457124
85	Male pseudohermaphroditism (HP:0000037)	1.79696466
86	Abnormality of T cell physiology (HP:0011840)	1.78692088
87	Hypoplasia of the ulna (HP:0003022)	1.77257592
88	Renal cortical cysts (HP:0000803)	1.76920839
89	Hyperglycinemia (HP:0002154)	1.76905508
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76427918
91	Asplenia (HP:0001746)	1.74624532
92	Hyperphosphaturia (HP:0003109)	1.74481482
93	Severe visual impairment (HP:0001141)	1.72318024
94	Encephalitis (HP:0002383)	1.72242604
95	Glycosuria (HP:0003076)	1.68189955
96	Abnormality of urine glucose concentration (HP:0011016)	1.68189955
97	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.68137458
98	Hypoplasia of the uterus (HP:0000013)	1.67945097
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.67629984
100	Polyuria (HP:0000103)	1.66138567

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.50748899
2	MAP4K2	3.62769824
3	CDK19	3.25315524
4	KDR	2.98483776
5	ADRBK2	2.71061269
6	PINK1	2.67788301
7	MAP3K12	2.49837786
8	VRK2	2.36692946
9	MAP4K1	2.35394130
10	TAOK3	2.33037750
11	ZAK	2.31286822
12	GRK1	2.29240972
13	TESK2	2.26576410
14	WNK4	2.09398728
15	PASK	1.91435625
16	FRK	1.79290122
17	TLK1	1.77533707
18	BCKDK	1.65107871
19	NUAK1	1.59048945
20	ITK	1.51242484
21	OXSR1	1.49244202
22	MUSK	1.44471060
23	VRK1	1.34479913
24	TEC	1.30601972
25	STK16	1.30408103
26	CDC7	1.21633324
27	NLK	1.19836744
28	WNK3	1.19500597
29	MST4	1.19325291
30	STK39	1.18547495
31	MAP3K11	1.12066564
32	DYRK2	1.11446874
33	CDK3	1.07552664
34	MYLK	1.05956269
35	TRIM28	1.05585671
36	PRKCQ	1.02177535
37	SYK	1.02122076
38	SCYL2	1.01439700
39	MAP2K6	0.97294810
40	INSRR	0.92356831
41	GRK7	0.86441028
42	IKBKB	0.85093270
43	RPS6KA4	0.83257634
44	NME1	0.82597457
45	LYN	0.82309249
46	OBSCN	0.80225622
47	RPS6KA5	0.77435350
48	MAPK13	0.76997204
49	IKBKE	0.76824341
50	IRAK4	0.76569832
51	PIK3CA	0.76534705
52	FES	0.72818033
53	LCK	0.72803770
54	BTK	0.69570397
55	DAPK1	0.69066279
56	PLK4	0.67372214
57	BMPR1B	0.66345870
58	ADRBK1	0.66183093
59	CSF1R	0.65774963
60	TIE1	0.65669558
61	CAMKK2	0.65243453
62	EIF2AK3	0.64425609
63	KIT	0.63549488
64	LIMK1	0.62928065
65	CSNK1G1	0.60232015
66	GRK6	0.60017852
67	TNK2	0.58976518
68	DAPK3	0.58346281
69	PLK2	0.54906689
70	DAPK2	0.53743857
71	ERBB3	0.53022358
72	PIM1	0.52897244
73	MAPKAPK3	0.51787630
74	NTRK3	0.51646942
75	PRKACA	0.49536013
76	CAMK1	0.49514528
77	LRRK2	0.49259755
78	CSNK2A1	0.47908368
79	CSK	0.47305724
80	CSNK2A2	0.46623179
81	TAF1	0.46515541
82	IGF1R	0.46494012
83	CAMKK1	0.45721666
84	DYRK1A	0.44199523
85	PRKCA	0.42240311
86	CAMK2A	0.39391777
87	CSNK1A1	0.37684496
88	GRK5	0.34526653
89	PRKCG	0.34520343
90	MAPK15	0.34349690
91	ZAP70	0.31968051
92	CHEK2	0.30300712
93	PTK2B	0.29469369
94	PRKG1	0.29182302
95	ILK	0.28141923
96	AURKA	0.27948942
97	PRKCE	0.27908700
98	PIK3CG	0.27791233
99	DYRK1B	0.27508167
100	PHKG2	0.27095617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.57983527
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.41138429
3	Parkinsons disease_Homo sapiens_hsa05012	3.55484077
4	Proteasome_Homo sapiens_hsa03050	3.44729798
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.36761079
6	Alzheimers disease_Homo sapiens_hsa05010	2.47139340
7	Huntingtons disease_Homo sapiens_hsa05016	2.35490109
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.29394952
9	Protein export_Homo sapiens_hsa03060	2.28709890
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.24774508
11	Asthma_Homo sapiens_hsa05310	2.23309808
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.16846514
13	Allograft rejection_Homo sapiens_hsa05330	2.16670791
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.99683985
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.98017307
16	RNA polymerase_Homo sapiens_hsa03020	1.96627810
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.91478128
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79787127
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78228864
20	Phototransduction_Homo sapiens_hsa04744	1.73725640
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.71121092
22	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.48970206
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47299645
24	RNA degradation_Homo sapiens_hsa03018	1.45511053
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.37980304
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36198255
27	Homologous recombination_Homo sapiens_hsa03440	1.35453493
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33257796
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27001541
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18212428
31	Basal transcription factors_Homo sapiens_hsa03022	1.11568109
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.08966161
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.07492036
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.00698765
35	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.98155765
36	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97907907
37	Nicotine addiction_Homo sapiens_hsa05033	0.96593878
38	Caffeine metabolism_Homo sapiens_hsa00232	0.96043511
39	Olfactory transduction_Homo sapiens_hsa04740	0.93665881
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.93036948
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92457371
42	Butanoate metabolism_Homo sapiens_hsa00650	0.88356539
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87257884
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84375468
45	One carbon pool by folate_Homo sapiens_hsa00670	0.82085909
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81706601
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79175307
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79062829
49	Viral myocarditis_Homo sapiens_hsa05416	0.78047555
50	Retinol metabolism_Homo sapiens_hsa00830	0.77853848
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77090588
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.76969572
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73378638
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70942453
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.70713541
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70538028
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69873981
58	Taste transduction_Homo sapiens_hsa04742	0.68453833
59	Peroxisome_Homo sapiens_hsa04146	0.66344465
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65440927
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63764780
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61818213
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60774979
64	Propanoate metabolism_Homo sapiens_hsa00640	0.58620166
65	Purine metabolism_Homo sapiens_hsa00230	0.57718180
66	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53172022
67	Metabolic pathways_Homo sapiens_hsa01100	0.52984297
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51082327
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50820766
70	Malaria_Homo sapiens_hsa05144	0.49851714
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49301181
72	Mismatch repair_Homo sapiens_hsa03430	0.48435117
73	Spliceosome_Homo sapiens_hsa03040	0.48423184
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.46914434
75	Morphine addiction_Homo sapiens_hsa05032	0.46382727
76	Sulfur metabolism_Homo sapiens_hsa00920	0.44768712
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43401197
78	Salivary secretion_Homo sapiens_hsa04970	0.42790539
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39229351
80	DNA replication_Homo sapiens_hsa03030	0.38061288
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37859366
82	African trypanosomiasis_Homo sapiens_hsa05143	0.37088151
83	Regulation of autophagy_Homo sapiens_hsa04140	0.35981553
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.35644128
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.35007143
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34914106
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34735832
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34082551
89	GABAergic synapse_Homo sapiens_hsa04727	0.31368955
90	Base excision repair_Homo sapiens_hsa03410	0.31093045
91	Measles_Homo sapiens_hsa05162	0.26461572
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25831388
93	Fatty acid degradation_Homo sapiens_hsa00071	0.25556171
94	Sulfur relay system_Homo sapiens_hsa04122	0.23773774
95	RNA transport_Homo sapiens_hsa03013	0.23622658
96	Herpes simplex infection_Homo sapiens_hsa05168	0.22054692
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19050309
98	Insulin secretion_Homo sapiens_hsa04911	0.16672250
99	Serotonergic synapse_Homo sapiens_hsa04726	0.15483274
100	Mineral absorption_Homo sapiens_hsa04978	0.12732782

RPS27AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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