RPS27AP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)5.82138739
2ATP synthesis coupled proton transport (GO:0015986)5.82138739
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.59453278
4ribosomal small subunit assembly (GO:0000028)5.48165611
5viral transcription (GO:0019083)5.35671945
6translational termination (GO:0006415)5.26648355
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.71076399
8cotranslational protein targeting to membrane (GO:0006613)4.65933615
9protein targeting to ER (GO:0045047)4.64326260
10behavioral response to nicotine (GO:0035095)4.51416234
11negative regulation of cytosolic calcium ion concentration (GO:0051481)4.45856211
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.45082894
13translational elongation (GO:0006414)4.43389485
14protein localization to endoplasmic reticulum (GO:0070972)4.42872748
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.38770182
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.26703200
17DNA deamination (GO:0045006)4.13611442
18opioid receptor signaling pathway (GO:0038003)4.10725996
19maturation of SSU-rRNA (GO:0030490)4.09418735
20ribosomal small subunit biogenesis (GO:0042274)4.08030973
21respiratory electron transport chain (GO:0022904)3.93590565
22electron transport chain (GO:0022900)3.91359107
23chaperone-mediated protein transport (GO:0072321)3.91094006
24cellular protein complex disassembly (GO:0043624)3.86697891
25protein neddylation (GO:0045116)3.77990811
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.67517987
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.67167669
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.64839750
29NADH dehydrogenase complex assembly (GO:0010257)3.64839750
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64839750
31viral life cycle (GO:0019058)3.63758866
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58697408
33translational initiation (GO:0006413)3.57850626
34ATP biosynthetic process (GO:0006754)3.55401378
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.54843233
36protein complex biogenesis (GO:0070271)3.53196045
37GTP biosynthetic process (GO:0006183)3.53075775
38purine nucleoside triphosphate biosynthetic process (GO:0009145)3.51380632
39negative regulation of cAMP-mediated signaling (GO:0043951)3.49171664
40piRNA metabolic process (GO:0034587)3.48679059
41regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.43994807
42behavioral response to ethanol (GO:0048149)3.36841255
43translation (GO:0006412)3.35336406
44water-soluble vitamin biosynthetic process (GO:0042364)3.34418914
45interferon-gamma production (GO:0032609)3.32569165
46preassembly of GPI anchor in ER membrane (GO:0016254)3.30950084
47fucose catabolic process (GO:0019317)3.30774808
48L-fucose metabolic process (GO:0042354)3.30774808
49L-fucose catabolic process (GO:0042355)3.30774808
50ribosomal large subunit biogenesis (GO:0042273)3.30706767
51aldehyde catabolic process (GO:0046185)3.30599052
52hydrogen ion transmembrane transport (GO:1902600)3.28132915
53proton transport (GO:0015992)3.26657281
54mitochondrial respiratory chain complex assembly (GO:0033108)3.23947615
55hydrogen transport (GO:0006818)3.22683426
56platelet dense granule organization (GO:0060155)3.21776995
57regulation of immunoglobulin secretion (GO:0051023)3.16914984
58protein complex disassembly (GO:0043241)3.15375260
59epithelial cilium movement (GO:0003351)3.12568308
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10246710
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.09534345
62macromolecular complex disassembly (GO:0032984)3.08954630
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.02752992
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01142182
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01142182
66kynurenine metabolic process (GO:0070189)3.00568240
67protein targeting to membrane (GO:0006612)3.00371525
68regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.98492844
69regulation of isotype switching to IgG isotypes (GO:0048302)2.94661660
70GPI anchor metabolic process (GO:0006505)2.86922418
71regulation of cellular respiration (GO:0043457)2.86648651
72indolalkylamine metabolic process (GO:0006586)2.83749601
73nonmotile primary cilium assembly (GO:0035058)2.82560738
74UTP biosynthetic process (GO:0006228)2.82114705
75positive regulation of cAMP-mediated signaling (GO:0043950)2.77820002
76proteasome assembly (GO:0043248)2.77160214
77nuclear-transcribed mRNA catabolic process (GO:0000956)2.76172641
78GPI anchor biosynthetic process (GO:0006506)2.75440298
79positive regulation of interleukin-17 production (GO:0032740)2.75256005
80regulation of acrosome reaction (GO:0060046)2.74928525
81response to xenobiotic stimulus (GO:0009410)2.71602126
82protein-cofactor linkage (GO:0018065)2.71441203
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.70081773
84termination of RNA polymerase III transcription (GO:0006386)2.70081773
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69657779
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.68373115
87ether lipid metabolic process (GO:0046485)2.65445962
88regulation of hypersensitivity (GO:0002883)2.65008844
89tryptophan catabolic process (GO:0006569)2.61892314
90indole-containing compound catabolic process (GO:0042436)2.61892314
91indolalkylamine catabolic process (GO:0046218)2.61892314
92negative regulation of mast cell activation (GO:0033004)2.60961415
93mRNA catabolic process (GO:0006402)2.58950018
94CTP metabolic process (GO:0046036)2.58711124
95CTP biosynthetic process (GO:0006241)2.58711124
96negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.58442490
97regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.58186297
98cellular component biogenesis (GO:0044085)2.57999592
99cytidine deamination (GO:0009972)2.57980322
100cytidine catabolic process (GO:0006216)2.57980322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.86801566
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.42265977
3VDR_22108803_ChIP-Seq_LS180_Human3.26079319
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.82506472
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62695629
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57920857
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49737377
8TAF15_26573619_Chip-Seq_HEK293_Human2.37917971
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.37806014
10ZNF274_21170338_ChIP-Seq_K562_Hela2.19824963
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15026341
12PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97775178
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95638316
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.89014098
15IRF1_19129219_ChIP-ChIP_H3396_Human1.88791397
16IGF1R_20145208_ChIP-Seq_DFB_Human1.83367365
17EWS_26573619_Chip-Seq_HEK293_Human1.83022754
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.79615102
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79329146
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76089172
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72338889
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71924478
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71338391
24TP53_22573176_ChIP-Seq_HFKS_Human1.69506284
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67718067
26ELK1_19687146_ChIP-ChIP_HELA_Human1.62860433
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62070416
28NANOG_19829295_ChIP-Seq_ESCs_Human1.59052233
29SOX2_19829295_ChIP-Seq_ESCs_Human1.59052233
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55699577
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55699577
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54573645
33VDR_23849224_ChIP-Seq_CD4+_Human1.53830786
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50433453
35P300_19829295_ChIP-Seq_ESCs_Human1.46441396
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42243654
37MYC_18940864_ChIP-ChIP_HL60_Human1.39960355
38CBP_20019798_ChIP-Seq_JUKART_Human1.38274156
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38274156
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37565777
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37341492
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.36441951
43FOXP3_21729870_ChIP-Seq_TREG_Human1.36357080
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.35217083
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33597484
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.33597484
47ER_23166858_ChIP-Seq_MCF-7_Human1.32307996
48BCAT_22108803_ChIP-Seq_LS180_Human1.31583264
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31488532
50FUS_26573619_Chip-Seq_HEK293_Human1.29968942
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26415437
52NANOG_20526341_ChIP-Seq_ESCs_Human1.25896376
53GBX2_23144817_ChIP-Seq_PC3_Human1.25511496
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25357085
55HTT_18923047_ChIP-ChIP_STHdh_Human1.25344967
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24890169
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.24178786
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22231741
59GATA3_26560356_Chip-Seq_TH2_Human1.21898608
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15854339
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.15511360
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15439347
63NCOR_22424771_ChIP-Seq_293T_Human1.15189467
64AR_20517297_ChIP-Seq_VCAP_Human1.14733038
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14629706
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.14247301
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13483611
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12782106
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09899491
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09565686
71TTF2_22483619_ChIP-Seq_HELA_Human1.06862598
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.06457706
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05589803
74TAF2_19829295_ChIP-Seq_ESCs_Human1.05255931
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04693124
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04691137
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.04481821
78TCF4_22108803_ChIP-Seq_LS180_Human1.04312594
79MYC_19829295_ChIP-Seq_ESCs_Human1.02941290
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02485990
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02152936
82ERG_20517297_ChIP-Seq_VCAP_Human1.01829767
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.00847592
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.00641726
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.00221438
86ERA_21632823_ChIP-Seq_H3396_Human0.98354711
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.97408821
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.97221640
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97219598
90FLI1_21867929_ChIP-Seq_TH2_Mouse0.96764294
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.96307890
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96063729
93HOXB7_26014856_ChIP-Seq_BT474_Human0.95234701
94TCF4_23295773_ChIP-Seq_U87_Human0.93752397
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93330258
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92841958
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92437640
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91839457
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91457888
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.91446695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.62122146
2MP0006292_abnormal_olfactory_placode3.24176177
3MP0001835_abnormal_antigen_presentation3.06993035
4MP0005671_abnormal_response_to2.60041194
5MP0003787_abnormal_imprinting2.53901108
6MP0001986_abnormal_taste_sensitivity2.51159934
7MP0001968_abnormal_touch/_nociception2.49258162
8MP0008875_abnormal_xenobiotic_pharmacok2.42014430
9MP0002876_abnormal_thyroid_physiology2.36412850
10MP0005646_abnormal_pituitary_gland2.34197297
11MP0003646_muscle_fatigue2.25316941
12MP0003880_abnormal_central_pattern2.24048998
13MP0005551_abnormal_eye_electrophysiolog2.23818241
14MP0006072_abnormal_retinal_apoptosis2.18526212
15MP0008877_abnormal_DNA_methylation2.17049790
16MP0004142_abnormal_muscle_tone2.15775509
17MP0005377_hearing/vestibular/ear_phenot2.07946192
18MP0003878_abnormal_ear_physiology2.07946192
19MP0008872_abnormal_physiological_respon1.93358922
20MP0000685_abnormal_immune_system1.90620252
21MP0009764_decreased_sensitivity_to1.80950673
22MP0004145_abnormal_muscle_electrophysio1.76376167
23MP0002102_abnormal_ear_morphology1.72947683
24MP0003806_abnormal_nucleotide_metabolis1.70065528
25MP0001790_abnormal_immune_system1.66937439
26MP0005387_immune_system_phenotype1.66937439
27MP0002272_abnormal_nervous_system1.63584911
28MP0003195_calcinosis1.62669903
29MP0005360_urolithiasis1.57403221
30MP0004742_abnormal_vestibular_system1.50996088
31MP0006276_abnormal_autonomic_nervous1.47618511
32MP0002163_abnormal_gland_morphology1.47332534
33MP0009745_abnormal_behavioral_response1.45567463
34MP0002148_abnormal_hypersensitivity_rea1.45280222
35MP0005645_abnormal_hypothalamus_physiol1.44740529
36MP0005423_abnormal_somatic_nervous1.43744678
37MP0008789_abnormal_olfactory_epithelium1.42210126
38MP0002095_abnormal_skin_pigmentation1.41805919
39MP0001501_abnormal_sleep_pattern1.40924749
40MP0004885_abnormal_endolymph1.40672987
41MP0001800_abnormal_humoral_immune1.38614821
42MP0001919_abnormal_reproductive_system1.37950466
43MP0001529_abnormal_vocalization1.35496902
44MP0005503_abnormal_tendon_morphology1.35005831
45MP0009333_abnormal_splenocyte_physiolog1.33406011
46MP0001873_stomach_inflammation1.32622974
47MP0003186_abnormal_redox_activity1.30632472
48MP0001905_abnormal_dopamine_level1.28633429
49MP0002736_abnormal_nociception_after1.26424602
50MP0009785_altered_susceptibility_to1.26150177
51MP0001984_abnormal_olfaction1.23933342
52MP0001970_abnormal_pain_threshold1.22614900
53MP0009046_muscle_twitch1.17305107
54MP0002837_dystrophic_cardiac_calcinosis1.15943659
55MP0003879_abnormal_hair_cell1.13863039
56MP0003122_maternal_imprinting1.12117063
57MP0001486_abnormal_startle_reflex1.12057025
58MP0005253_abnormal_eye_physiology1.11309596
59MP0003121_genomic_imprinting1.11004361
60MP0001485_abnormal_pinna_reflex1.10195285
61MP0005389_reproductive_system_phenotype1.08966534
62MP0002733_abnormal_thermal_nociception1.06278255
63MP0005084_abnormal_gallbladder_morpholo1.04964044
64MP0004147_increased_porphyrin_level1.04723176
65MP0002557_abnormal_social/conspecific_i1.03317977
66MP0005195_abnormal_posterior_eye1.02666235
67MP0002234_abnormal_pharynx_morphology1.02386374
68MP0000372_irregular_coat_pigmentation0.99429533
69MP0006035_abnormal_mitochondrial_morpho0.96155021
70MP0001963_abnormal_hearing_physiology0.94686724
71MP0000230_abnormal_systemic_arterial0.91793071
72MP0005394_taste/olfaction_phenotype0.91199532
73MP0005499_abnormal_olfactory_system0.91199532
74MP0003638_abnormal_response/metabolism_0.91179154
75MP0000427_abnormal_hair_cycle0.89952827
76MP0002693_abnormal_pancreas_physiology0.88987271
77MP0001765_abnormal_ion_homeostasis0.88741272
78MP0009780_abnormal_chondrocyte_physiolo0.86401903
79MP0008058_abnormal_DNA_repair0.86129755
80MP0005000_abnormal_immune_tolerance0.85626354
81MP0002723_abnormal_immune_serum0.85620844
82MP0003866_abnormal_defecation0.85452266
83MP0005636_abnormal_mineral_homeostasis0.84905061
84MP0002938_white_spotting0.84735265
85MP0001348_abnormal_lacrimal_gland0.84602807
86MP0003045_fibrosis0.83407388
87MP0002452_abnormal_antigen_presenting0.82723113
88MP0002572_abnormal_emotion/affect_behav0.80600108
89MP0002752_abnormal_somatic_nervous0.77460638
90MP0001440_abnormal_grooming_behavior0.77181300
91MP0005379_endocrine/exocrine_gland_phen0.76863561
92MP0005085_abnormal_gallbladder_physiolo0.76748820
93MP0000049_abnormal_middle_ear0.74798379
94MP0002420_abnormal_adaptive_immunity0.74696260
95MP0002184_abnormal_innervation0.74542845
96MP0001819_abnormal_immune_cell0.73694966
97MP0010386_abnormal_urinary_bladder0.71640486
98MP0000026_abnormal_inner_ear0.71152391
99MP0000631_abnormal_neuroendocrine_gland0.69001420
100MP0003635_abnormal_synaptic_transmissio0.68650390

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.38496002
2Thyroid-stimulating hormone excess (HP:0002925)4.34666445
3Mitochondrial inheritance (HP:0001427)4.02313403
4Increased CSF lactate (HP:0002490)3.95854710
5Increased hepatocellular lipid droplets (HP:0006565)3.93859836
6Lipid accumulation in hepatocytes (HP:0006561)3.92434039
7Abnormal mitochondria in muscle tissue (HP:0008316)3.72250119
8Acute encephalopathy (HP:0006846)3.64656710
9Progressive macrocephaly (HP:0004481)3.61450982
10Abnormality of midbrain morphology (HP:0002418)3.57791834
11Molar tooth sign on MRI (HP:0002419)3.57791834
123-Methylglutaconic aciduria (HP:0003535)3.56838007
13Pancreatic cysts (HP:0001737)3.42582396
14Reticulocytopenia (HP:0001896)3.40382132
15Abnormality of cells of the erythroid lineage (HP:0012130)3.34872866
16Elevated erythrocyte sedimentation rate (HP:0003565)3.32408614
17Renal Fanconi syndrome (HP:0001994)3.15284526
18Hepatocellular necrosis (HP:0001404)3.14722577
19Optic disc pallor (HP:0000543)3.08170729
20Stomatitis (HP:0010280)3.07479838
21Pancreatic fibrosis (HP:0100732)3.03721980
22Congenital, generalized hypertrichosis (HP:0004540)3.01898611
23Agitation (HP:0000713)2.84186506
24Congenital stationary night blindness (HP:0007642)2.82691243
25Cerebral edema (HP:0002181)2.79628455
26Exertional dyspnea (HP:0002875)2.79138763
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77127526
28Attenuation of retinal blood vessels (HP:0007843)2.71009276
29IgG deficiency (HP:0004315)2.67101920
30Abolished electroretinogram (ERG) (HP:0000550)2.67072302
31Abnormal number of erythroid precursors (HP:0012131)2.66117848
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63897742
33Macrocytic anemia (HP:0001972)2.61469049
34Hepatic necrosis (HP:0002605)2.60252856
35Nephronophthisis (HP:0000090)2.51586142
36Tubular atrophy (HP:0000092)2.51489874
37Type II lissencephaly (HP:0007260)2.51169511
38Abnormality of renal resorption (HP:0011038)2.48804935
39Increased intramyocellular lipid droplets (HP:0012240)2.44174388
40Increased serum lactate (HP:0002151)2.41974638
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.39921871
42Large for gestational age (HP:0001520)2.39748252
43Abnormal rod and cone electroretinograms (HP:0008323)2.35846143
44Increased IgM level (HP:0003496)2.35833868
45Intestinal atresia (HP:0011100)2.33376618
46Absent/shortened dynein arms (HP:0200106)2.32407575
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.32407575
48Asplenia (HP:0001746)2.29781390
49Increased corneal curvature (HP:0100692)2.29639612
50Keratoconus (HP:0000563)2.29639612
51True hermaphroditism (HP:0010459)2.27795728
52Abnormality of the renal medulla (HP:0100957)2.26724176
53Stenosis of the external auditory canal (HP:0000402)2.26389600
54Pendular nystagmus (HP:0012043)2.23111226
55Abnormal respiratory epithelium morphology (HP:0012253)2.22830675
56Abnormal respiratory motile cilium morphology (HP:0005938)2.22830675
57Cystic liver disease (HP:0006706)2.22788116
58Constricted visual fields (HP:0001133)2.22043084
59Hypoproteinemia (HP:0003075)2.19710960
60Increased muscle lipid content (HP:0009058)2.17386374
61Polydipsia (HP:0001959)2.12490199
62Abnormal drinking behavior (HP:0030082)2.12490199
63Abnormal ciliary motility (HP:0012262)2.11351600
64Methylmalonic acidemia (HP:0002912)2.09374978
65Congenital ichthyosiform erythroderma (HP:0007431)2.08806486
66Medial flaring of the eyebrow (HP:0010747)2.08190530
67Abnormality of the pons (HP:0007361)2.05990945
68Abnormal respiratory motile cilium physiology (HP:0012261)2.05629406
69Pallor (HP:0000980)2.04849232
70Leukodystrophy (HP:0002415)2.03397695
71Pancreatic islet-cell hyperplasia (HP:0004510)2.02153654
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94626380
73Abnormality of the renal cortex (HP:0011035)1.94573624
74Polyuria (HP:0000103)1.94381085
75Lactic acidosis (HP:0003128)1.93187768
76Exercise intolerance (HP:0003546)1.90638965
77Respiratory failure (HP:0002878)1.90025319
78Rhinitis (HP:0012384)1.89869198
79Poor head control (HP:0002421)1.89795677
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88020852
81Hypoplasia of the pons (HP:0012110)1.86542783
82Inability to walk (HP:0002540)1.84076722
83Respiratory difficulties (HP:0002880)1.82228954
84Supernumerary spleens (HP:0009799)1.81600220
85Methylmalonic aciduria (HP:0012120)1.80197820
86Chronic bronchitis (HP:0004469)1.78901523
87Bony spicule pigmentary retinopathy (HP:0007737)1.78384635
88Abnormality of urine glucose concentration (HP:0011016)1.77951131
89Glycosuria (HP:0003076)1.77951131
90Median cleft lip (HP:0000161)1.77745096
91Sclerocornea (HP:0000647)1.77682819
92Myositis (HP:0100614)1.77301937
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77301309
94Optic nerve hypoplasia (HP:0000609)1.76116326
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75791225
96Hyperphosphaturia (HP:0003109)1.74982124
97Postaxial foot polydactyly (HP:0001830)1.74176276
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73431217
99Lethargy (HP:0001254)1.71862907
100Decreased circulating renin level (HP:0003351)1.69605062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.95401486
2TXK4.89643593
3WNK42.98750390
4MAP3K122.97284979
5FRK2.92961547
6ZAK2.82971218
7TLK12.63064153
8GRK12.42049152
9PINK12.24163197
10STK162.11066898
11NUAK12.09924500
12CDK191.99914131
13MAP4K21.96771962
14TAOK31.93067552
15ADRBK11.72380428
16STK391.71680104
17MAP4K11.71087402
18DYRK21.57584887
19MYLK1.56632307
20BMPR1B1.43986741
21TEC1.43267741
22OXSR11.37917872
23WNK31.35595651
24VRK21.26653054
25ITK1.23438300
26PRKCG1.17776615
27MST41.12887485
28EIF2AK31.05649458
29BCKDK1.01820137
30BTK0.98858099
31PASK0.97167033
32DYRK30.94165639
33TNIK0.92754214
34PHKG20.91957327
35PHKG10.91957327
36PRKCE0.90213993
37WNK10.87028252
38MUSK0.85462679
39IKBKB0.83764415
40SYK0.83491248
41TGFBR10.83214599
42PRKCQ0.83081492
43INSRR0.80501874
44VRK10.79531443
45BMPR20.78414213
46DAPK30.77474576
47GRK70.70910477
48ILK0.69071489
49ACVR1B0.66514081
50PAK30.64897291
51DAPK10.64297170
52NME10.64294183
53EIF2AK20.63313335
54MAP2K60.62719444
55PIK3CA0.62093555
56MAP2K20.60906973
57PRKACA0.60573199
58MAP2K70.59003275
59MAPK70.58533274
60GRK60.57946193
61CAMK2A0.57432376
62TIE10.56316108
63OBSCN0.56032517
64MAPK130.53898765
65RPS6KA50.53495490
66LYN0.53468600
67MAP3K140.53083140
68RPS6KA60.52603577
69TNK20.52386094
70MAP3K40.51569151
71PRKCH0.51148533
72AURKB0.49357800
73PIK3CG0.49267197
74PLK20.49219034
75PRKCA0.48248053
76NEK10.48038213
77MKNK20.47571251
78CSNK2A20.47400990
79LCK0.47172218
80GRK50.47009058
81PRKG10.44983654
82LIMK10.43707077
83ERBB20.41678489
84SCYL20.41294706
85ATR0.40797423
86CSF1R0.40238242
87NTRK20.40167872
88IRAK10.39547279
89EPHA40.38426870
90CAMK10.36831081
91KIT0.36468520
92MKNK10.36301748
93NLK0.36199720
94TESK10.35953080
95DAPK20.35635641
96CSNK2A10.35071487
97IGF1R0.34871512
98KDR0.33223522
99CSNK1G30.32447553
100RPS6KC10.31556997

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.39532005
2Oxidative phosphorylation_Homo sapiens_hsa001904.02586254
3Asthma_Homo sapiens_hsa053103.89081572
4Parkinsons disease_Homo sapiens_hsa050123.32372239
5Allograft rejection_Homo sapiens_hsa053302.87427766
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.82745614
7Protein export_Homo sapiens_hsa030602.79030154
8Autoimmune thyroid disease_Homo sapiens_hsa053202.66502668
9Graft-versus-host disease_Homo sapiens_hsa053322.38497906
10Cardiac muscle contraction_Homo sapiens_hsa042602.34659797
11Alzheimers disease_Homo sapiens_hsa050102.30886085
12Proteasome_Homo sapiens_hsa030502.30208418
13Huntingtons disease_Homo sapiens_hsa050162.22080403
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18615998
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13167501
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07168346
17Type I diabetes mellitus_Homo sapiens_hsa049401.90559634
18RNA polymerase_Homo sapiens_hsa030201.76758801
19Phototransduction_Homo sapiens_hsa047441.69705008
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56879383
21Basal transcription factors_Homo sapiens_hsa030221.52230275
22Homologous recombination_Homo sapiens_hsa034401.51112256
23Linoleic acid metabolism_Homo sapiens_hsa005911.45312842
24Caffeine metabolism_Homo sapiens_hsa002321.40911520
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33665658
26RNA degradation_Homo sapiens_hsa030181.26578529
27Rheumatoid arthritis_Homo sapiens_hsa053231.23054167
28Primary immunodeficiency_Homo sapiens_hsa053401.14889938
29Antigen processing and presentation_Homo sapiens_hsa046121.13340758
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12673893
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10106647
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07291074
33Olfactory transduction_Homo sapiens_hsa047401.02380253
34Chemical carcinogenesis_Homo sapiens_hsa052040.95832796
35Steroid hormone biosynthesis_Homo sapiens_hsa001400.95255793
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95174607
37Butanoate metabolism_Homo sapiens_hsa006500.93823447
38One carbon pool by folate_Homo sapiens_hsa006700.91719391
39Nitrogen metabolism_Homo sapiens_hsa009100.90672652
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90259787
41Tryptophan metabolism_Homo sapiens_hsa003800.88925125
42Morphine addiction_Homo sapiens_hsa050320.88303351
43Nucleotide excision repair_Homo sapiens_hsa034200.88193586
44Pyrimidine metabolism_Homo sapiens_hsa002400.84318495
45Propanoate metabolism_Homo sapiens_hsa006400.82161760
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80953495
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80320517
48Fanconi anemia pathway_Homo sapiens_hsa034600.80063929
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78577677
50Sulfur metabolism_Homo sapiens_hsa009200.76184359
51Retinol metabolism_Homo sapiens_hsa008300.74669977
52Taste transduction_Homo sapiens_hsa047420.72223963
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70436125
54Viral myocarditis_Homo sapiens_hsa054160.70018371
55Collecting duct acid secretion_Homo sapiens_hsa049660.69635195
56Peroxisome_Homo sapiens_hsa041460.69416129
57Hematopoietic cell lineage_Homo sapiens_hsa046400.68031371
58Purine metabolism_Homo sapiens_hsa002300.67869182
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67607194
60Arachidonic acid metabolism_Homo sapiens_hsa005900.67278047
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64510363
62Staphylococcus aureus infection_Homo sapiens_hsa051500.63325622
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.61456940
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60627064
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.59919240
66Nicotine addiction_Homo sapiens_hsa050330.59549095
67Metabolic pathways_Homo sapiens_hsa011000.55477816
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54780189
69Regulation of autophagy_Homo sapiens_hsa041400.53662554
70Mismatch repair_Homo sapiens_hsa034300.49963161
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.47945207
72Systemic lupus erythematosus_Homo sapiens_hsa053220.44805258
73Mineral absorption_Homo sapiens_hsa049780.44235248
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.43945648
75T cell receptor signaling pathway_Homo sapiens_hsa046600.43799885
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43309682
77Ether lipid metabolism_Homo sapiens_hsa005650.42963898
78Sulfur relay system_Homo sapiens_hsa041220.42959178
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42787776
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41497179
81Ovarian steroidogenesis_Homo sapiens_hsa049130.39045020
82Salivary secretion_Homo sapiens_hsa049700.37404373
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.36936643
84RNA transport_Homo sapiens_hsa030130.36936548
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33419502
86Fatty acid degradation_Homo sapiens_hsa000710.30435289
87Serotonergic synapse_Homo sapiens_hsa047260.29603545
88Base excision repair_Homo sapiens_hsa034100.28873605
89Glutamatergic synapse_Homo sapiens_hsa047240.28707009
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.28301396
91Glutathione metabolism_Homo sapiens_hsa004800.27866488
92Starch and sucrose metabolism_Homo sapiens_hsa005000.27763397
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27760620
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27708320
95GABAergic synapse_Homo sapiens_hsa047270.24671412
96Dorso-ventral axis formation_Homo sapiens_hsa043200.24200292
97Fat digestion and absorption_Homo sapiens_hsa049750.24121135
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23687033
99beta-Alanine metabolism_Homo sapiens_hsa004100.23289214
100Glycerolipid metabolism_Homo sapiens_hsa005610.22972159

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »