RPS27L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.08775100
2viral transcription (GO:0019083)5.93854131
3ribosomal small subunit biogenesis (GO:0042274)5.85299960
4translational termination (GO:0006415)5.77727416
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.74417463
6chaperone-mediated protein transport (GO:0072321)5.38650988
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29042822
8respiratory electron transport chain (GO:0022904)5.24075686
9protein complex biogenesis (GO:0070271)5.19206473
10cotranslational protein targeting to membrane (GO:0006613)5.18666359
11electron transport chain (GO:0022900)5.17825543
12protein targeting to ER (GO:0045047)5.17287913
13mitochondrial respiratory chain complex I assembly (GO:0032981)5.04125612
14NADH dehydrogenase complex assembly (GO:0010257)5.04125612
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.04125612
16translational elongation (GO:0006414)5.03168003
17maturation of SSU-rRNA (GO:0030490)5.02881050
18DNA deamination (GO:0045006)4.94269178
19protein localization to endoplasmic reticulum (GO:0070972)4.91031623
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.90450556
21mitochondrial respiratory chain complex assembly (GO:0033108)4.88481332
22ribosomal large subunit biogenesis (GO:0042273)4.81901218
23translational initiation (GO:0006413)4.60962860
24proteasome assembly (GO:0043248)4.54326045
25viral life cycle (GO:0019058)4.53301055
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.42907253
27cellular protein complex disassembly (GO:0043624)4.42895378
28protein neddylation (GO:0045116)4.40940946
29water-soluble vitamin biosynthetic process (GO:0042364)4.27355655
30ribonucleoprotein complex biogenesis (GO:0022613)4.07480214
31* translation (GO:0006412)4.04584791
32formation of translation preinitiation complex (GO:0001731)3.77059504
33ATP biosynthetic process (GO:0006754)3.76130941
34protein complex disassembly (GO:0043241)3.74904157
35hydrogen ion transmembrane transport (GO:1902600)3.72328934
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71796899
37platelet dense granule organization (GO:0060155)3.61557295
38sequestering of actin monomers (GO:0042989)3.61503876
39respiratory chain complex IV assembly (GO:0008535)3.60160490
40telomere maintenance via semi-conservative replication (GO:0032201)3.58911020
41macromolecular complex disassembly (GO:0032984)3.55434841
42cytochrome complex assembly (GO:0017004)3.50866907
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48822957
44DNA strand elongation involved in DNA replication (GO:0006271)3.48486120
45termination of RNA polymerase III transcription (GO:0006386)3.48212948
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.48212948
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.48051309
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46079434
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45909011
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.45816341
51rRNA processing (GO:0006364)3.44656352
52regulation of cellular amino acid metabolic process (GO:0006521)3.43930164
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43827328
54protein targeting to membrane (GO:0006612)3.42331155
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40031300
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40031300
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.38594818
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38177424
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38177424
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38177424
61negative regulation of ligase activity (GO:0051352)3.37571253
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37571253
63ribosome assembly (GO:0042255)3.37277060
64proton transport (GO:0015992)3.36329154
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34890931
66intracellular protein transmembrane import (GO:0044743)3.34225130
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.33649786
68antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32581250
69rRNA metabolic process (GO:0016072)3.30904355
70DNA strand elongation (GO:0022616)3.30557869
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30361114
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.30361114
73cellular component biogenesis (GO:0044085)3.29031763
74hydrogen transport (GO:0006818)3.28125836
75rRNA modification (GO:0000154)3.26661662
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26033039
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.24482273
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21778945
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21778945
80CENP-A containing nucleosome assembly (GO:0034080)3.21195045
81telomere maintenance via recombination (GO:0000722)3.19853744
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19694717
83ATP synthesis coupled proton transport (GO:0015986)3.19694717
84DNA replication initiation (GO:0006270)3.16475096
85ribosome biogenesis (GO:0042254)3.16270807
86mRNA catabolic process (GO:0006402)3.16191952
87pseudouridine synthesis (GO:0001522)3.15482994
88protein-cofactor linkage (GO:0018065)3.14283677
89chromatin remodeling at centromere (GO:0031055)3.12949102
90behavioral response to nicotine (GO:0035095)3.12408561
91spliceosomal snRNP assembly (GO:0000387)3.11022277
92nucleobase biosynthetic process (GO:0046112)3.10533428
93purine nucleobase biosynthetic process (GO:0009113)3.08483828
94folic acid-containing compound biosynthetic process (GO:0009396)3.07485436
95DNA replication checkpoint (GO:0000076)3.05696392
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05466995
97establishment of integrated proviral latency (GO:0075713)3.01071119
98RNA catabolic process (GO:0006401)2.98157940
99positive regulation of ligase activity (GO:0051351)2.97473283
100mitotic metaphase plate congression (GO:0007080)2.95330622
1017-methylguanosine mRNA capping (GO:0006370)2.92803383
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91435218
103kinetochore assembly (GO:0051382)2.90338296
104ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89975683
105signal peptide processing (GO:0006465)2.89678598
106transcription-coupled nucleotide-excision repair (GO:0006283)2.89628545
107RNA capping (GO:0036260)2.87818142
1087-methylguanosine RNA capping (GO:0009452)2.87818142
109mitotic recombination (GO:0006312)2.86455931
110nucleobase-containing small molecule interconversion (GO:0015949)2.85827839
111peptidyl-histidine modification (GO:0018202)2.85655105
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85105522
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85066626
114kinetochore organization (GO:0051383)2.83942504
115cell cycle G1/S phase transition (GO:0044843)2.82438184
116G1/S transition of mitotic cell cycle (GO:0000082)2.82438184
117regulation of mitochondrial translation (GO:0070129)2.82264115
118folic acid metabolic process (GO:0046655)2.80340846
119nonmotile primary cilium assembly (GO:0035058)2.80123980
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.79909458
121deoxyribonucleotide biosynthetic process (GO:0009263)2.78550388
122spliceosomal complex assembly (GO:0000245)2.78410867
123mitochondrion morphogenesis (GO:0070584)2.77335698
124DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77114676
125establishment of protein localization to mitochondrion (GO:0072655)2.77045995
126positive regulation of cell cycle arrest (GO:0071158)2.75131916
127transcription from RNA polymerase I promoter (GO:0006360)2.74384384
128protein targeting to mitochondrion (GO:0006626)2.74206936
129telomere maintenance via telomere lengthening (GO:0010833)2.73210072
130antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.71736881
131pteridine-containing compound biosynthetic process (GO:0042559)2.68558404
132inner mitochondrial membrane organization (GO:0007007)2.68523896
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.67696617
134GTP biosynthetic process (GO:0006183)2.66993791
135nucleoside triphosphate biosynthetic process (GO:0009142)2.62517562
136organelle disassembly (GO:1903008)2.62507083
137sulfation (GO:0051923)2.62009412
138protein localization to mitochondrion (GO:0070585)2.61544699
139protein targeting (GO:0006605)2.60740813
140establishment of protein localization to membrane (GO:0090150)2.58577853
141mitochondrial transport (GO:0006839)2.56049029
142anterograde synaptic vesicle transport (GO:0048490)2.55542686
143mannosylation (GO:0097502)2.53146007
144rRNA methylation (GO:0031167)2.50770238
145vitamin biosynthetic process (GO:0009110)2.49328444
146oxidative phosphorylation (GO:0006119)2.47650764
147aldehyde catabolic process (GO:0046185)2.45203777
148indolalkylamine catabolic process (GO:0046218)2.43820589
149tryptophan catabolic process (GO:0006569)2.43820589
150indole-containing compound catabolic process (GO:0042436)2.43820589
151maturation of 5.8S rRNA (GO:0000460)2.43387161
152establishment of protein localization to organelle (GO:0072594)2.41842926
153epithelial cilium movement (GO:0003351)2.41341252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.01246915
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.35094540
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80964579
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75844590
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.69948941
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.44518347
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23130824
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10303149
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.09539171
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09004701
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92698202
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88295615
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73983754
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65653081
15ZNF274_21170338_ChIP-Seq_K562_Hela2.64794732
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54247825
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48484510
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46975675
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37648639
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35457779
21XRN2_22483619_ChIP-Seq_HELA_Human2.32026742
22VDR_23849224_ChIP-Seq_CD4+_Human2.31972861
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30905507
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30857167
25VDR_22108803_ChIP-Seq_LS180_Human2.25477438
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25368563
27DCP1A_22483619_ChIP-Seq_HELA_Human2.25321889
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19315967
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16959918
30EWS_26573619_Chip-Seq_HEK293_Human2.14041480
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13294339
32FUS_26573619_Chip-Seq_HEK293_Human2.09854769
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.08891881
34ELK1_19687146_ChIP-ChIP_HELA_Human1.98517230
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85847871
36FOXP3_21729870_ChIP-Seq_TREG_Human1.82854402
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.82556443
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82451000
39TTF2_22483619_ChIP-Seq_HELA_Human1.77335729
40GABP_19822575_ChIP-Seq_HepG2_Human1.76774864
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71756609
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.69011861
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.68851662
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65468527
45AR_21909140_ChIP-Seq_LNCAP_Human1.60747142
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59964891
47P300_19829295_ChIP-Seq_ESCs_Human1.59852719
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59085476
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58646019
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58591252
51* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55288274
52* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52828318
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52255738
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50382059
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50091140
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50008712
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.48532881
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.47814682
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46906899
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45547675
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45358421
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43319174
63IRF1_19129219_ChIP-ChIP_H3396_Human1.42828685
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40478614
65* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39615161
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39387766
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39255125
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39066066
69* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39031196
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36768803
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35956762
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35058013
73IGF1R_20145208_ChIP-Seq_DFB_Human1.35055476
74GBX2_23144817_ChIP-Seq_PC3_Human1.33177644
75* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31614691
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31540276
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.30367329
78TP53_22573176_ChIP-Seq_HFKS_Human1.28560976
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27097122
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26908396
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23499654
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21691337
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21274545
84NANOG_19829295_ChIP-Seq_ESCs_Human1.20559617
85SOX2_19829295_ChIP-Seq_ESCs_Human1.20559617
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20438868
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20113696
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.19409630
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18907297
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.18893001
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17879796
92TAF15_26573619_Chip-Seq_HEK293_Human1.15090170
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14821214
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14728145
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.14182389
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12854800
97KDM5A_27292631_Chip-Seq_BREAST_Human1.12621582
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11721192
99AR_20517297_ChIP-Seq_VCAP_Human1.11477957
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09875580
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09409143
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.08390078
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08390078
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07689337
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07643761
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06996509
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.06433270
108ER_23166858_ChIP-Seq_MCF-7_Human1.04784864
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04729304
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04623523
111TFEB_21752829_ChIP-Seq_HELA_Human1.02984913
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02119789
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01553754
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01401018
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01281976
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01257290
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01186877
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.01163727
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00844435
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.00068770
121EZH2_22144423_ChIP-Seq_EOC_Human0.99681077
122SPI1_23547873_ChIP-Seq_NB4_Human0.98788661
123* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98786324
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96965061
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96950308
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.96160432
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96037265
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95651280
129ERG_20517297_ChIP-Seq_VCAP_Human0.95439388
130* MYC_18940864_ChIP-ChIP_HL60_Human0.95131612
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94968904
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94455012
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91834146
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.91154686
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91150252
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.90737587
137* NOTCH1_21737748_ChIP-Seq_TLL_Human0.90634149
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90285955
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90282295
140IRF8_21731497_ChIP-ChIP_J774_Mouse0.90210537
141* TP53_18474530_ChIP-ChIP_U2OS_Human0.89994649
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.89353430
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89289812
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88518644
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88365916
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88365916
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88365916
148BCAT_22108803_ChIP-Seq_LS180_Human0.86422029
149FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86409562
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85302441
151AR_25329375_ChIP-Seq_VCAP_Human0.85040974
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84945222
153SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84296652
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80594599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.52002350
2MP0003806_abnormal_nucleotide_metabolis4.09031298
3MP0004957_abnormal_blastocyst_morpholog3.47740799
4MP0003186_abnormal_redox_activity2.95864511
5MP0006292_abnormal_olfactory_placode2.88847185
6MP0003077_abnormal_cell_cycle2.68352913
7MP0009379_abnormal_foot_pigmentation2.67387795
8MP0003111_abnormal_nucleus_morphology2.60340215
9MP0010094_abnormal_chromosome_stability2.60034161
10MP0002837_dystrophic_cardiac_calcinosis2.34803910
11MP0008057_abnormal_DNA_replication2.33693523
12MP0003011_delayed_dark_adaptation2.29792914
13MP0003718_maternal_effect2.26725793
14MP0008932_abnormal_embryonic_tissue2.21809784
15MP0005171_absent_coat_pigmentation2.17717323
16MP0002653_abnormal_ependyma_morphology2.06336401
17MP0008007_abnormal_cellular_replicative2.04055414
18MP0008058_abnormal_DNA_repair2.01974578
19MP0006072_abnormal_retinal_apoptosis1.97965067
20MP0004142_abnormal_muscle_tone1.90347284
21MP0003941_abnormal_skin_development1.78857737
22MP0008789_abnormal_olfactory_epithelium1.77883399
23MP0009333_abnormal_splenocyte_physiolog1.71839239
24MP0000372_irregular_coat_pigmentation1.70058816
25MP0002102_abnormal_ear_morphology1.64986384
26MP0010386_abnormal_urinary_bladder1.63123051
27MP0005503_abnormal_tendon_morphology1.61936430
28MP0001485_abnormal_pinna_reflex1.61725444
29MP0000569_abnormal_digit_pigmentation1.60722684
30MP0005551_abnormal_eye_electrophysiolog1.57974368
31MP0003786_premature_aging1.55865370
32MP0005174_abnormal_tail_pigmentation1.55582985
33MP0000490_abnormal_crypts_of1.53976004
34MP0002132_abnormal_respiratory_system1.49435483
35MP0001529_abnormal_vocalization1.49236484
36MP0009785_altered_susceptibility_to1.48927492
37MP0001853_heart_inflammation1.48516422
38MP0005408_hypopigmentation1.46551466
39MP0002638_abnormal_pupillary_reflex1.46443943
40MP0000049_abnormal_middle_ear1.44776478
41MP0002148_abnormal_hypersensitivity_rea1.42974940
42MP0002095_abnormal_skin_pigmentation1.42940065
43MP0009250_abnormal_appendicular_skeleto1.42317160
44MP0010352_gastrointestinal_tract_polyps1.40452570
45MP0001835_abnormal_antigen_presentation1.39428631
46MP0002282_abnormal_trachea_morphology1.38370387
47MP0003136_yellow_coat_color1.36122513
48MP0002160_abnormal_reproductive_system1.35638311
49MP0006036_abnormal_mitochondrial_physio1.32530393
50MP0000350_abnormal_cell_proliferation1.32285227
51MP0005253_abnormal_eye_physiology1.31540592
52MP0003937_abnormal_limbs/digits/tail_de1.30544446
53MP0003252_abnormal_bile_duct1.30401738
54MP0003283_abnormal_digestive_organ1.29440095
55MP0003436_decreased_susceptibility_to1.28736527
56MP0002139_abnormal_hepatobiliary_system1.28493374
57MP0002234_abnormal_pharynx_morphology1.26952420
58MP0000858_altered_metastatic_potential1.25755441
59MP0001730_embryonic_growth_arrest1.24831838
60MP0000631_abnormal_neuroendocrine_gland1.24081855
61MP0002876_abnormal_thyroid_physiology1.23724203
62MP0010030_abnormal_orbit_morphology1.21479539
63MP0005360_urolithiasis1.18409834
64MP0000026_abnormal_inner_ear1.15567894
65MP0005195_abnormal_posterior_eye1.14671242
66MP0005085_abnormal_gallbladder_physiolo1.14148149
67MP0001286_abnormal_eye_development1.13494003
68MP0004147_increased_porphyrin_level1.12993540
69MP0006035_abnormal_mitochondrial_morpho1.12722975
70MP0003950_abnormal_plasma_membrane1.12554912
71MP0002019_abnormal_tumor_incidence1.12021460
72MP0002396_abnormal_hematopoietic_system1.09951830
73MP0009384_cardiac_valve_regurgitation1.09250220
74MP0005083_abnormal_biliary_tract1.08223989
75MP0002736_abnormal_nociception_after1.07788929
76MP0009053_abnormal_anal_canal1.07410288
77MP0001324_abnormal_eye_pigmentation1.07295725
78MP0002751_abnormal_autonomic_nervous1.05473626
79MP0000313_abnormal_cell_death1.03990574
80MP0000358_abnormal_cell_content/1.02511865
81MP0005451_abnormal_body_composition1.01663157
82MP0009840_abnormal_foam_cell1.01540524
83MP0002277_abnormal_respiratory_mucosa1.01521042
84MP0001764_abnormal_homeostasis1.00562025
85MP0005025_abnormal_response_to1.00428629
86MP0005084_abnormal_gallbladder_morpholo0.99968612
87MP0001905_abnormal_dopamine_level0.98987240
88MP0003755_abnormal_palate_morphology0.98519271
89MP0003890_abnormal_embryonic-extraembry0.96636462
90MP0008872_abnormal_physiological_respon0.95766686
91MP0005501_abnormal_skin_physiology0.95526071
92MP0000685_abnormal_immune_system0.94273679
93MP0002295_abnormal_pulmonary_circulatio0.93065300
94MP0006054_spinal_hemorrhage0.92979713
95MP0005391_vision/eye_phenotype0.92702706
96MP0005397_hematopoietic_system_phenotyp0.92561711
97MP0001545_abnormal_hematopoietic_system0.92561711
98MP0002138_abnormal_hepatobiliary_system0.92477471
99MP0001666_abnormal_nutrient_absorption0.92235826
100MP0002796_impaired_skin_barrier0.91655303
101MP0002090_abnormal_vision0.91547143
102MP0000647_abnormal_sebaceous_gland0.90896702
103MP0002233_abnormal_nose_morphology0.90072559
104MP0002163_abnormal_gland_morphology0.89428935
105MP0003656_abnormal_erythrocyte_physiolo0.89224880
106MP0001697_abnormal_embryo_size0.88953910
107MP0001542_abnormal_bone_strength0.87817809
108MP0004381_abnormal_hair_follicle0.87584325
109MP0005000_abnormal_immune_tolerance0.87128904
110MP0003724_increased_susceptibility_to0.85911795
111MP0010307_abnormal_tumor_latency0.85437622
112MP0004133_heterotaxia0.85022855
113MP0008469_abnormal_protein_level0.84911396
114MP0002080_prenatal_lethality0.83597749
115MP0000566_synostosis0.83084027
116MP0000427_abnormal_hair_cycle0.82789265
117MP0003195_calcinosis0.82693585
118MP0005379_endocrine/exocrine_gland_phen0.82509490
119MP0005499_abnormal_olfactory_system0.82412977
120MP0005394_taste/olfaction_phenotype0.82412977
121MP0005395_other_phenotype0.82289637
122MP0005671_abnormal_response_to0.82096950
123MP0001299_abnormal_eye_distance/0.81133013
124MP0002697_abnormal_eye_size0.80994676
125MP0001984_abnormal_olfaction0.80510488
126MP0009697_abnormal_copulation0.79284447
127MP0005023_abnormal_wound_healing0.78046015
128MP0003938_abnormal_ear_development0.77984141
129MP0000538_abnormal_urinary_bladder0.77936002
130MP0004885_abnormal_endolymph0.77637849
131MP0005266_abnormal_metabolism0.76918060
132MP0002722_abnormal_immune_system0.76915062
133MP0005365_abnormal_bile_salt0.76751569
134MP0003315_abnormal_perineum_morphology0.76066245
135MP0005332_abnormal_amino_acid0.75929496
136MP0005220_abnormal_exocrine_pancreas0.75881261
137MP0005380_embryogenesis_phenotype0.75526118
138MP0001672_abnormal_embryogenesis/_devel0.75526118
139MP0002419_abnormal_innate_immunity0.75339968
140MP0002928_abnormal_bile_duct0.75028178
141MP0002938_white_spotting0.75008803
142MP0009643_abnormal_urine_homeostasis0.74542234
143MP0000689_abnormal_spleen_morphology0.74312802
144MP0000750_abnormal_muscle_regeneration0.74094678
145MP0004019_abnormal_vitamin_homeostasis0.73623312
146MP0002452_abnormal_antigen_presenting0.73166196
147MP0001293_anophthalmia0.73012566
148MP0008875_abnormal_xenobiotic_pharmacok0.72157530
149MP0001243_abnormal_dermal_layer0.72143079
150MP0009764_decreased_sensitivity_to0.72043049
151MP0000627_abnormal_mammary_gland0.72031270
152MP0006276_abnormal_autonomic_nervous0.71827781
153MP0002060_abnormal_skin_morphology0.71355294
154MP0005636_abnormal_mineral_homeostasis0.71321638
155MP0005389_reproductive_system_phenotype0.71319556
156MP0005187_abnormal_penis_morphology0.71274690
157MP0004043_abnormal_pH_regulation0.71150827
158MP0002723_abnormal_immune_serum0.71109231
159MP0004742_abnormal_vestibular_system0.71095713
160MP0001845_abnormal_inflammatory_respons0.70518314
161MP0003567_abnormal_fetal_cardiomyocyte0.70297425
162MP0002752_abnormal_somatic_nervous0.70252429
163MP0002006_tumorigenesis0.70043593
164MP0008438_abnormal_cutaneous_collagen0.69941834
165MP0002098_abnormal_vibrissa_morphology0.69266092
166MP0005646_abnormal_pituitary_gland0.68899898
167MP0002405_respiratory_system_inflammati0.68609148
168MP0003646_muscle_fatigue0.68474526
169MP0002429_abnormal_blood_cell0.68361597

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.27082103
2Abnormal number of erythroid precursors (HP:0012131)5.63010950
3Reticulocytopenia (HP:0001896)5.20262003
4Macrocytic anemia (HP:0001972)4.36940785
5Pallor (HP:0000980)3.80851948
6Pancreatic cysts (HP:0001737)3.78627709
7Birth length less than 3rd percentile (HP:0003561)3.66210738
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.57677214
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.57677214
10Pancreatic fibrosis (HP:0100732)3.57513184
11Abnormality of midbrain morphology (HP:0002418)3.54134193
12Molar tooth sign on MRI (HP:0002419)3.54134193
13True hermaphroditism (HP:0010459)3.48384615
14Oral leukoplakia (HP:0002745)3.33135921
15Breast hypoplasia (HP:0003187)3.27780118
16Acute necrotizing encephalopathy (HP:0006965)3.27393725
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.25645694
18Increased hepatocellular lipid droplets (HP:0006565)3.14202811
193-Methylglutaconic aciduria (HP:0003535)3.12763101
20Mitochondrial inheritance (HP:0001427)3.11700722
21Rough bone trabeculation (HP:0100670)3.05220943
22Aplastic anemia (HP:0001915)3.04521392
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00908051
24Abnormal mitochondria in muscle tissue (HP:0008316)2.95995690
25Lipid accumulation in hepatocytes (HP:0006561)2.95888873
26Abnormal hemoglobin (HP:0011902)2.95547035
27Hepatic necrosis (HP:0002605)2.94420159
28Exertional dyspnea (HP:0002875)2.94246809
29Acute encephalopathy (HP:0006846)2.88912480
30Hepatocellular necrosis (HP:0001404)2.84931820
31Increased CSF lactate (HP:0002490)2.83797484
32Nephronophthisis (HP:0000090)2.82310101
33Carpal bone hypoplasia (HP:0001498)2.79840775
34Multiple enchondromatosis (HP:0005701)2.79590786
35Medial flaring of the eyebrow (HP:0010747)2.75479653
36Trismus (HP:0000211)2.73025557
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70229800
38Septo-optic dysplasia (HP:0100842)2.66750943
39Renal Fanconi syndrome (HP:0001994)2.65401582
40Increased serum lactate (HP:0002151)2.61654817
41Cerebral edema (HP:0002181)2.59635558
42Poor head control (HP:0002421)2.53500924
43Sclerocornea (HP:0000647)2.50592066
44Optic disc pallor (HP:0000543)2.49499665
45Increased intramyocellular lipid droplets (HP:0012240)2.44976462
46Microretrognathia (HP:0000308)2.44045027
47Methylmalonic acidemia (HP:0002912)2.43585317
48Progressive macrocephaly (HP:0004481)2.43346326
49Type I transferrin isoform profile (HP:0003642)2.42024493
50Sparse eyelashes (HP:0000653)2.41840842
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.41755968
52Abnormality of alanine metabolism (HP:0010916)2.41000535
53Hyperalaninemia (HP:0003348)2.41000535
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41000535
55Methylmalonic aciduria (HP:0012120)2.39144587
56Abnormal trabecular bone morphology (HP:0100671)2.37010937
57Congenital, generalized hypertrichosis (HP:0004540)2.33040410
58Abnormality of the renal medulla (HP:0100957)2.31349048
59Congenital ichthyosiform erythroderma (HP:0007431)2.29358087
60Nausea (HP:0002018)2.28146377
61Microvesicular hepatic steatosis (HP:0001414)2.28030483
62Reduced antithrombin III activity (HP:0001976)2.27444835
63Stenosis of the external auditory canal (HP:0000402)2.21257365
64Hyperglycinemia (HP:0002154)2.20752612
65Cerebral hypomyelination (HP:0006808)2.19881566
66Premature graying of hair (HP:0002216)2.17247337
67Increased muscle lipid content (HP:0009058)2.15359937
68Exercise intolerance (HP:0003546)2.14785593
69Lactic acidosis (HP:0003128)2.14708623
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.14033266
71Congenital primary aphakia (HP:0007707)2.13224422
72Abnormality of pyrimidine metabolism (HP:0004353)2.10636876
73Leukodystrophy (HP:0002415)2.10518001
74Respiratory failure (HP:0002878)2.08655942
75Secondary amenorrhea (HP:0000869)2.07096417
76Hypoplasia of the pons (HP:0012110)2.06002179
77Absent thumb (HP:0009777)2.05693333
78Rib fusion (HP:0000902)2.04819661
79Pancytopenia (HP:0001876)2.04091256
80Abnormality of the pons (HP:0007361)2.03857533
81Cystic liver disease (HP:0006706)2.03242528
82Pendular nystagmus (HP:0012043)2.02626986
83Abnormality of serum amino acid levels (HP:0003112)2.02332686
84Gait imbalance (HP:0002141)2.02332650
85Concave nail (HP:0001598)2.01682916
86Abnormality of the anterior horn cell (HP:0006802)2.00116974
87Degeneration of anterior horn cells (HP:0002398)2.00116974
88Respiratory difficulties (HP:0002880)2.00041330
89Parakeratosis (HP:0001036)1.99672977
90Cleft eyelid (HP:0000625)1.98770608
91Abnormal biliary tract physiology (HP:0012439)1.98188798
92Bile duct proliferation (HP:0001408)1.98188798
9311 pairs of ribs (HP:0000878)1.97289303
94Abnormality of reticulocytes (HP:0004312)1.96298010
95Nephrogenic diabetes insipidus (HP:0009806)1.95220205
96Absent radius (HP:0003974)1.95032997
97Male pseudohermaphroditism (HP:0000037)1.94026907
98Furrowed tongue (HP:0000221)1.93799713
99Optic nerve hypoplasia (HP:0000609)1.93767194
100Anencephaly (HP:0002323)1.93641275
101Congenital stationary night blindness (HP:0007642)1.92817643
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92757986
103Abnormality of the renal cortex (HP:0011035)1.92561268
104Lethargy (HP:0001254)1.91443401
105Patellar aplasia (HP:0006443)1.90737880
106Increased serum pyruvate (HP:0003542)1.90632161
107Abnormality of glycolysis (HP:0004366)1.90632161
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88990431
109Increased corneal curvature (HP:0100692)1.88269282
110Keratoconus (HP:0000563)1.88269282
111Type II lissencephaly (HP:0007260)1.87622360
112Glycosuria (HP:0003076)1.87150764
113Abnormality of urine glucose concentration (HP:0011016)1.87150764
114Colon cancer (HP:0003003)1.83884742
115Megaloblastic anemia (HP:0001889)1.83582097
116Aplasia/hypoplasia of the uterus (HP:0008684)1.83474851
117Thrombocytosis (HP:0001894)1.83124108
118Large for gestational age (HP:0001520)1.82901511
119Abnormality of placental membranes (HP:0011409)1.82678179
120Amniotic constriction ring (HP:0009775)1.82678179
121Hyperphosphaturia (HP:0003109)1.82398985
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82000386
123Aplasia/Hypoplasia of the patella (HP:0006498)1.80704719
124Cellular immunodeficiency (HP:0005374)1.80515950
125Tubular atrophy (HP:0000092)1.80178869
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80063466
127Anophthalmia (HP:0000528)1.79954566
128Abnormal protein glycosylation (HP:0012346)1.79905794
129Abnormal glycosylation (HP:0012345)1.79905794
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79905794
131Abnormal protein N-linked glycosylation (HP:0012347)1.79905794
132Dicarboxylic aciduria (HP:0003215)1.79814851
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79814851
134Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79145397
135Absent forearm bone (HP:0003953)1.78917861
136Aplasia involving forearm bones (HP:0009822)1.78917861
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.78617759
138Selective tooth agenesis (HP:0001592)1.78399688
139Vaginal atresia (HP:0000148)1.77817060
140Premature ovarian failure (HP:0008209)1.76981114
141Genital tract atresia (HP:0001827)1.76973869
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.76882447
143Chronic hepatic failure (HP:0100626)1.75936204
144Progressive muscle weakness (HP:0003323)1.75528213
145Hypobetalipoproteinemia (HP:0003563)1.74628897
146Generalized aminoaciduria (HP:0002909)1.74279270
147Triphalangeal thumb (HP:0001199)1.73409351
148Abolished electroretinogram (ERG) (HP:0000550)1.72028983
149Renal cortical cysts (HP:0000803)1.70099159
150Supernumerary spleens (HP:0009799)1.69448802
151Confusion (HP:0001289)1.69051352
152CNS demyelination (HP:0007305)1.68960480
153Partial duplication of the phalanx of hand (HP:0009999)1.68879154
154Abnormality of renal resorption (HP:0011038)1.68851964
155Horseshoe kidney (HP:0000085)1.68019656
156Chorioretinal atrophy (HP:0000533)1.67524802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.62135058
2VRK24.34572102
3BUB14.31040410
4EIF2AK13.56601534
5WEE13.34797528
6STK162.92882297
7PIM22.76451598
8PBK2.72558288
9EIF2AK32.71450573
10FRK2.64691751
11ADRBK22.49517127
12SRPK12.29755926
13PLK42.27639844
14TAF12.23618524
15TESK22.20225559
16NUAK12.17028513
17VRK12.14456947
18GRK12.04621161
19TLK11.88944865
20EPHA21.87457653
21ACVR1B1.82833406
22EPHB21.80326768
23RPS6KB21.73032852
24WNK41.69457644
25TESK11.69319747
26CDC71.68835367
27MYLK1.60520946
28BCKDK1.58458356
29MAP3K121.58213143
30MST41.57066018
31WNK31.57055322
32INSRR1.55417228
33IRAK31.53044858
34BRSK21.46645937
35DYRK31.44593748
36KDR1.42476164
37MAP4K21.41863477
38ABL21.36301869
39MST1R1.35465678
40PLK11.35172478
41TTK1.34683148
42AURKB1.31862651
43RPS6KA41.24156993
44TNIK1.21834765
45EIF2AK21.21792648
46ZAK1.21431849
47NME11.20798708
48LIMK11.18977139
49MAP3K111.13207427
50CDK71.12760975
51MAPKAPK31.11098482
52AURKA1.09424693
53MAP3K81.08218082
54NEK21.06619394
55LRRK21.05778261
56PINK11.05720542
57STK391.05661558
58TIE11.03858469
59MKNK11.02465819
60PNCK0.98822600
61CASK0.97842724
62MUSK0.97532886
63OXSR10.96624947
64IKBKB0.96477443
65PIK3CA0.96437992
66IRAK40.96215387
67CDK190.95222359
68ADRBK10.92447001
69DYRK20.92149516
70PIM10.91654384
71STK40.90201319
72BRAF0.88667941
73BLK0.87611236
74TYK20.86170109
75GRK70.85939601
76PLK20.83806754
77ATR0.80337990
78PAK40.79308385
79MAP3K30.78944603
80PIK3CG0.78390695
81ARAF0.77627676
82PRKCG0.77337601
83RPS6KA50.76535297
84MET0.75826000
85CSNK1G30.74907621
86CSNK1G10.74117051
87SCYL20.73353167
88CHEK20.73161795
89MAP2K70.72380555
90PAK10.71961584
91CSNK1G20.71090707
92CSNK2A10.70653621
93PASK0.70530846
94NEK90.69819644
95STK100.69657462
96NEK10.68798172
97MAP3K140.68346857
98MAPKAPK50.68305531
99PRKCE0.66484964
100CSNK1A1L0.66182559
101PLK30.65978066
102MAP2K20.65824579
103MAPK150.64447730
104PAK30.63757141
105CSNK2A20.62882467
106STK38L0.62656353
107FLT30.61067947
108MAP3K40.60803650
109PDK20.59561525
110TGFBR10.59484171
111CAMKK20.58594823
112ILK0.56438415
113TBK10.56069956
114TEC0.53238798
115CDK40.53147892
116BRSK10.52194204
117TSSK60.45734465
118CHEK10.45147403
119CDK80.44982139
120MOS0.44579273
121DDR20.41018245
122AKT30.40904409
123ERN10.39649630
124JAK30.39624410
125FGFR20.39445346
126PRKCI0.39327029
127GRK50.39059134
128MKNK20.38543401
129ERBB40.37802506
130BCR0.37645304
131CSNK1A10.37146990
132DAPK30.36737142
133PAK20.35858251
134LATS20.35187408
135BTK0.34793339
136LYN0.34583865
137TRPM70.34313549
138MELK0.33167181
139PRKACA0.31233826
140CDK60.31231411
141TXK0.31061696
142ATM0.30112214
143BMPR1B0.28822593
144MAPKAPK20.27708919
145STK30.27542460
146DYRK1B0.27525927
147CHUK0.26452264
148* CDK20.22412137

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.04647487
2Proteasome_Homo sapiens_hsa030504.17496045
3DNA replication_Homo sapiens_hsa030303.33385222
4RNA polymerase_Homo sapiens_hsa030203.28124233
5Mismatch repair_Homo sapiens_hsa034302.69984531
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59342453
7Pyrimidine metabolism_Homo sapiens_hsa002402.42045925
8Spliceosome_Homo sapiens_hsa030402.29930146
9Protein export_Homo sapiens_hsa030602.29812017
10Homologous recombination_Homo sapiens_hsa034402.18210506
11One carbon pool by folate_Homo sapiens_hsa006702.09676537
12Oxidative phosphorylation_Homo sapiens_hsa001902.04181249
13Nucleotide excision repair_Homo sapiens_hsa034202.03806653
14Cardiac muscle contraction_Homo sapiens_hsa042602.01346813
15Parkinsons disease_Homo sapiens_hsa050121.86290788
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83057189
17RNA transport_Homo sapiens_hsa030131.82710416
18Folate biosynthesis_Homo sapiens_hsa007901.82092080
19Base excision repair_Homo sapiens_hsa034101.80400575
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76431522
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50761305
22Huntingtons disease_Homo sapiens_hsa050161.48992151
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36653717
24p53 signaling pathway_Homo sapiens_hsa041151.36168919
25Cell cycle_Homo sapiens_hsa041101.34084041
26Basal transcription factors_Homo sapiens_hsa030221.32377678
27Glutathione metabolism_Homo sapiens_hsa004801.32326229
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32003846
29Nitrogen metabolism_Homo sapiens_hsa009101.27308792
30Fanconi anemia pathway_Homo sapiens_hsa034601.27193376
31RNA degradation_Homo sapiens_hsa030181.24054823
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20843041
33Propanoate metabolism_Homo sapiens_hsa006401.20710257
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20061429
35Non-homologous end-joining_Homo sapiens_hsa034501.18555259
36Butanoate metabolism_Homo sapiens_hsa006501.17715774
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16970648
38Sulfur relay system_Homo sapiens_hsa041221.14456523
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.12616575
40Purine metabolism_Homo sapiens_hsa002301.09809069
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08493540
42Alzheimers disease_Homo sapiens_hsa050101.05026244
43Phototransduction_Homo sapiens_hsa047441.03757761
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.00412191
45Pentose phosphate pathway_Homo sapiens_hsa000300.95767562
46Systemic lupus erythematosus_Homo sapiens_hsa053220.94864828
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91410774
48Selenocompound metabolism_Homo sapiens_hsa004500.87363243
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86630353
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85735945
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84470560
52Epstein-Barr virus infection_Homo sapiens_hsa051690.80749262
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79621176
54Legionellosis_Homo sapiens_hsa051340.78328243
55Graft-versus-host disease_Homo sapiens_hsa053320.76583119
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.76272828
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75673930
58Allograft rejection_Homo sapiens_hsa053300.74878938
59Collecting duct acid secretion_Homo sapiens_hsa049660.72718534
60Basal cell carcinoma_Homo sapiens_hsa052170.72351042
61Arachidonic acid metabolism_Homo sapiens_hsa005900.72116121
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71645768
63Chemical carcinogenesis_Homo sapiens_hsa052040.71632947
64Pyruvate metabolism_Homo sapiens_hsa006200.71590679
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71364828
66Fatty acid degradation_Homo sapiens_hsa000710.70909124
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70830654
68Biosynthesis of amino acids_Homo sapiens_hsa012300.70581692
69Mineral absorption_Homo sapiens_hsa049780.69082816
70Caffeine metabolism_Homo sapiens_hsa002320.68433010
71Arginine and proline metabolism_Homo sapiens_hsa003300.67464122
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67083409
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66550429
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65424161
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64808516
76Metabolic pathways_Homo sapiens_hsa011000.64806174
77Phenylalanine metabolism_Homo sapiens_hsa003600.64423903
78Herpes simplex infection_Homo sapiens_hsa051680.63926489
79Steroid biosynthesis_Homo sapiens_hsa001000.63535863
80Linoleic acid metabolism_Homo sapiens_hsa005910.62964334
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62141646
82Sulfur metabolism_Homo sapiens_hsa009200.59821882
83Peroxisome_Homo sapiens_hsa041460.59224348
84Regulation of autophagy_Homo sapiens_hsa041400.57587957
85Carbon metabolism_Homo sapiens_hsa012000.56140515
86Histidine metabolism_Homo sapiens_hsa003400.55841415
87Retinol metabolism_Homo sapiens_hsa008300.55184994
88Tyrosine metabolism_Homo sapiens_hsa003500.54298406
89Ether lipid metabolism_Homo sapiens_hsa005650.53714466
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.52688484
91Antigen processing and presentation_Homo sapiens_hsa046120.51314923
92Hedgehog signaling pathway_Homo sapiens_hsa043400.50126254
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49891408
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48018388
95Vitamin B6 metabolism_Homo sapiens_hsa007500.47635194
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45949401
97Fatty acid elongation_Homo sapiens_hsa000620.45594420
98Fat digestion and absorption_Homo sapiens_hsa049750.41972050
99Viral carcinogenesis_Homo sapiens_hsa052030.38493387
100beta-Alanine metabolism_Homo sapiens_hsa004100.37728345
101Vitamin digestion and absorption_Homo sapiens_hsa049770.37645089
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.37391090
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.37294142
104Other glycan degradation_Homo sapiens_hsa005110.37239522
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.36798322
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35866181
107Apoptosis_Homo sapiens_hsa042100.35335510
108Asthma_Homo sapiens_hsa053100.35315117
109TGF-beta signaling pathway_Homo sapiens_hsa043500.35129533
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34947319
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34822818
112Tryptophan metabolism_Homo sapiens_hsa003800.32920040
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.32529466
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31919833
115Fructose and mannose metabolism_Homo sapiens_hsa000510.29319911
116mRNA surveillance pathway_Homo sapiens_hsa030150.28562401
117Autoimmune thyroid disease_Homo sapiens_hsa053200.28450611
118Rheumatoid arthritis_Homo sapiens_hsa053230.28389346
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27634313
120Glycerolipid metabolism_Homo sapiens_hsa005610.27091343
121Nicotine addiction_Homo sapiens_hsa050330.27062818
122Measles_Homo sapiens_hsa051620.26917819
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26785036
124Galactose metabolism_Homo sapiens_hsa000520.26435054
125Malaria_Homo sapiens_hsa051440.25403749
126N-Glycan biosynthesis_Homo sapiens_hsa005100.23913176
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23282313
128Starch and sucrose metabolism_Homo sapiens_hsa005000.22780740
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21856933

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