RPS27P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.92473703
2ribosomal small subunit assembly (GO:0000028)6.90065935
3translational termination (GO:0006415)6.54487861
4maturation of SSU-rRNA (GO:0030490)6.04730436
5behavioral response to nicotine (GO:0035095)5.57831753
6translational elongation (GO:0006414)5.55231955
7ribosomal small subunit biogenesis (GO:0042274)5.54737561
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.47813271
9cotranslational protein targeting to membrane (GO:0006613)5.39402068
10protein targeting to ER (GO:0045047)5.38714625
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.17027156
12DNA deamination (GO:0045006)5.14298571
13viral life cycle (GO:0019058)5.08584868
14protein localization to endoplasmic reticulum (GO:0070972)5.08194614
15cellular protein complex disassembly (GO:0043624)4.88401100
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.62955097
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.20137412
18protein complex disassembly (GO:0043241)4.13961676
19translational initiation (GO:0006413)4.04998907
20ATP synthesis coupled proton transport (GO:0015986)4.00002438
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.00002438
22macromolecular complex disassembly (GO:0032984)3.87818899
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66359363
24protein targeting to membrane (GO:0006612)3.63087557
25protein neddylation (GO:0045116)3.61247128
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57695161
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57695161
28chaperone-mediated protein transport (GO:0072321)3.52409280
29regulation of isotype switching to IgG isotypes (GO:0048302)3.46624488
30auditory receptor cell differentiation (GO:0042491)3.44751084
31piRNA metabolic process (GO:0034587)3.39392050
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.38058100
33hypothalamus development (GO:0021854)3.36449389
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.32197719
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31063000
36translation (GO:0006412)3.26851268
37positive regulation of T cell apoptotic process (GO:0070234)3.26731534
38somite development (GO:0061053)3.26604303
39substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.22656241
40substrate-independent telencephalic tangential migration (GO:0021826)3.22656241
41cytidine metabolic process (GO:0046087)3.22466961
42cytidine catabolic process (GO:0006216)3.22466961
43cytidine deamination (GO:0009972)3.22466961
44protein complex biogenesis (GO:0070271)3.19892592
45tongue development (GO:0043586)3.18425515
46fucose catabolic process (GO:0019317)3.18208813
47L-fucose metabolic process (GO:0042354)3.18208813
48L-fucose catabolic process (GO:0042355)3.18208813
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17725534
50water-soluble vitamin biosynthetic process (GO:0042364)3.12513739
51mRNA catabolic process (GO:0006402)3.12167716
52cell proliferation in forebrain (GO:0021846)3.11404520
53epithelial cilium movement (GO:0003351)3.07520250
54ribosomal large subunit biogenesis (GO:0042273)3.05787281
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02471232
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.02471232
57NADH dehydrogenase complex assembly (GO:0010257)3.02471232
58synaptic transmission, cholinergic (GO:0007271)3.02089686
59pattern specification involved in kidney development (GO:0061004)2.99927003
60nonmotile primary cilium assembly (GO:0035058)2.99046828
61positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98627981
62negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91666691
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90999481
64electron transport chain (GO:0022900)2.88814654
65head development (GO:0060322)2.88213273
66axoneme assembly (GO:0035082)2.86828771
67pyrimidine ribonucleoside catabolic process (GO:0046133)2.86440622
68mitochondrial respiratory chain complex assembly (GO:0033108)2.86350264
69GTP biosynthetic process (GO:0006183)2.85925034
70respiratory electron transport chain (GO:0022904)2.83844627
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82702434
72RNA catabolic process (GO:0006401)2.81989559
73interferon-gamma production (GO:0032609)2.81733377
74rRNA catabolic process (GO:0016075)2.79910516
75positive regulation of defense response to virus by host (GO:0002230)2.78322275
76pyrimidine nucleobase catabolic process (GO:0006208)2.77399676
77spinal cord association neuron differentiation (GO:0021527)2.77025218
78parturition (GO:0007567)2.76454737
79positive regulation of respiratory burst (GO:0060267)2.74948139
80DNA methylation involved in gamete generation (GO:0043046)2.74452972
81axonemal dynein complex assembly (GO:0070286)2.74026104
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73876109
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73244588
84segment specification (GO:0007379)2.64228952
85regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.63721817
86cardiovascular system development (GO:0072358)2.63208434
87regulation of action potential (GO:0098900)2.61567002
88regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.61340072
89cellular component biogenesis (GO:0044085)2.61309227
90endoderm formation (GO:0001706)2.61263304
91cilium movement (GO:0003341)2.57018024
92protein polyglutamylation (GO:0018095)2.55754162
93transmission of nerve impulse (GO:0019226)2.55717523
94neuron fate determination (GO:0048664)2.55053006
95glycerophospholipid catabolic process (GO:0046475)2.54745578
96negative regulation of telomere maintenance (GO:0032205)2.53494187
97response to pheromone (GO:0019236)2.53010485
98ribonucleoprotein complex biogenesis (GO:0022613)2.52986756
99negative regulation of astrocyte differentiation (GO:0048712)2.49975607
100negative regulation of oligodendrocyte differentiation (GO:0048715)2.49794680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16017775
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.71378647
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.76505202
4VDR_22108803_ChIP-Seq_LS180_Human2.69624471
5ZNF274_21170338_ChIP-Seq_K562_Hela2.40268220
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36878419
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34618143
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99603558
9EST1_17652178_ChIP-ChIP_JURKAT_Human1.94573183
10IRF1_19129219_ChIP-ChIP_H3396_Human1.91668719
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85850186
12PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84578038
13ETS1_20019798_ChIP-Seq_JURKAT_Human1.83693540
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83386580
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.77707641
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74178579
17REST_21632747_ChIP-Seq_MESCs_Mouse1.68881516
18TAF2_19829295_ChIP-Seq_ESCs_Human1.62341706
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62094057
20ETV2_25802403_ChIP-Seq_MESCs_Mouse1.58947027
21YY1_21170310_ChIP-Seq_MESCs_Mouse1.58682784
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54256397
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54016304
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.51844758
25MYC_18940864_ChIP-ChIP_HL60_Human1.49937833
26GATA3_21878914_ChIP-Seq_MCF-7_Human1.49238542
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49187961
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.48112184
29TP53_22573176_ChIP-Seq_HFKS_Human1.47750513
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.47454527
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47117091
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44053361
33VDR_23849224_ChIP-Seq_CD4+_Human1.41309008
34ERA_21632823_ChIP-Seq_H3396_Human1.39539680
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39153251
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39009257
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.37622070
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37431715
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36593512
40NANOG_20526341_ChIP-Seq_ESCs_Human1.35312536
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34035697
42SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33770549
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31388579
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.29780249
45BCL6_27268052_Chip-Seq_Bcells_Human1.29470438
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28991501
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.27785128
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26296601
49NCOR_22424771_ChIP-Seq_293T_Human1.25336247
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24904835
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.20585643
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20379929
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18404883
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16491452
55CTCF_27219007_Chip-Seq_Bcells_Human1.15161641
56E2F1_20622854_ChIP-Seq_HELA_Human1.14783774
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12807312
58CTCF_20526341_ChIP-Seq_ESCs_Human1.11887368
59AR_20517297_ChIP-Seq_VCAP_Human1.10197159
60RNF2_27304074_Chip-Seq_NSC_Mouse1.09254348
61P53_21459846_ChIP-Seq_SAOS-2_Human1.07906825
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05936527
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05936527
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05428144
65SA1_27219007_Chip-Seq_Bcells_Human1.05303169
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04501527
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.04501527
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02126738
69DROSHA_22980978_ChIP-Seq_HELA_Human1.01965171
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01956705
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01947799
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.01921088
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01743991
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.00659375
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99766257
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99548152
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99121325
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99114605
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.96671555
80TTF2_22483619_ChIP-Seq_HELA_Human0.96047955
81OCT4_20526341_ChIP-Seq_ESCs_Human0.95096146
82MYC_19829295_ChIP-Seq_ESCs_Human0.94469477
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.94222577
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93342799
85FOXP3_21729870_ChIP-Seq_TREG_Human0.91622449
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.90148831
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89300061
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.88999917
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88906955
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88864483
91CBP_20019798_ChIP-Seq_JUKART_Human0.88864483
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88298781
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88032807
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87764505
95RAC3_21632823_ChIP-Seq_H3396_Human0.87529002
96OCT4_19829295_ChIP-Seq_ESCs_Human0.87528828
97HOXB7_26014856_ChIP-Seq_BT474_Human0.86838515
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.86781819
99STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86657819
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86337141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.19048940
2MP0006292_abnormal_olfactory_placode4.57641614
3MP0008877_abnormal_DNA_methylation2.58985410
4MP0003646_muscle_fatigue2.53645071
5MP0005671_abnormal_response_to2.47164890
6MP0002653_abnormal_ependyma_morphology2.37250599
7MP0002138_abnormal_hepatobiliary_system2.13688197
8MP0002163_abnormal_gland_morphology2.04151241
9MP0002837_dystrophic_cardiac_calcinosis2.01373371
10MP0003787_abnormal_imprinting2.01278755
11MP0004885_abnormal_endolymph1.95861518
12MP0005377_hearing/vestibular/ear_phenot1.94694303
13MP0003878_abnormal_ear_physiology1.94694303
14MP0006072_abnormal_retinal_apoptosis1.91351367
15MP0001835_abnormal_antigen_presentation1.88289326
16MP0004142_abnormal_muscle_tone1.88025357
17MP0008789_abnormal_olfactory_epithelium1.86922017
18MP0003122_maternal_imprinting1.86845262
19MP0001968_abnormal_touch/_nociception1.85736819
20MP0004742_abnormal_vestibular_system1.85083295
21MP0001485_abnormal_pinna_reflex1.83185356
22MP0002876_abnormal_thyroid_physiology1.77892347
23MP0008872_abnormal_physiological_respon1.73791913
24MP0001873_stomach_inflammation1.73502425
25MP0005646_abnormal_pituitary_gland1.72563223
26MP0006276_abnormal_autonomic_nervous1.71417333
27MP0002736_abnormal_nociception_after1.64239166
28MP0005645_abnormal_hypothalamus_physiol1.58852366
29MP0008875_abnormal_xenobiotic_pharmacok1.58449726
30MP0005551_abnormal_eye_electrophysiolog1.56902705
31MP0001293_anophthalmia1.54027355
32MP0001529_abnormal_vocalization1.52324674
33MP0003136_yellow_coat_color1.46495917
34MP0000778_abnormal_nervous_system1.45560507
35MP0005394_taste/olfaction_phenotype1.45112552
36MP0005499_abnormal_olfactory_system1.45112552
37MP0001986_abnormal_taste_sensitivity1.41873965
38MP0002102_abnormal_ear_morphology1.40727816
39MP0000631_abnormal_neuroendocrine_gland1.32398603
40MP0000685_abnormal_immune_system1.30093935
41MP0002272_abnormal_nervous_system1.26573787
42MP0001348_abnormal_lacrimal_gland1.26514348
43MP0004133_heterotaxia1.24038956
44MP0005423_abnormal_somatic_nervous1.22843584
45MP0000372_irregular_coat_pigmentation1.20035910
46MP0002095_abnormal_skin_pigmentation1.19480620
47MP0003121_genomic_imprinting1.18570597
48MP0000049_abnormal_middle_ear1.18556128
49MP0003123_paternal_imprinting1.16590707
50MP0005195_abnormal_posterior_eye1.16436984
51MP0004145_abnormal_muscle_electrophysio1.15828881
52MP0001440_abnormal_grooming_behavior1.14977481
53MP0003938_abnormal_ear_development1.13010639
54MP0004147_increased_porphyrin_level1.12725804
55MP0001663_abnormal_digestive_system1.12663286
56MP0002733_abnormal_thermal_nociception1.12485241
57MP0002557_abnormal_social/conspecific_i1.11301103
58MP0000026_abnormal_inner_ear1.11135844
59MP0002938_white_spotting1.10079879
60MP0001970_abnormal_pain_threshold1.09990901
61MP0009745_abnormal_behavioral_response1.09096771
62MP0005387_immune_system_phenotype1.08799101
63MP0001790_abnormal_immune_system1.08799101
64MP0001905_abnormal_dopamine_level1.04936135
65MP0005253_abnormal_eye_physiology1.02361122
66MP0005379_endocrine/exocrine_gland_phen1.01365814
67MP0008775_abnormal_heart_ventricle1.01358927
68MP0005389_reproductive_system_phenotype0.99700288
69MP0002752_abnormal_somatic_nervous0.99153722
70MP0001919_abnormal_reproductive_system0.98766528
71MP0001486_abnormal_startle_reflex0.98364427
72MP0009764_decreased_sensitivity_to0.95284502
73MP0002184_abnormal_innervation0.94207288
74MP0000569_abnormal_digit_pigmentation0.92763469
75MP0001984_abnormal_olfaction0.92343566
76MP0001800_abnormal_humoral_immune0.91276421
77MP0000955_abnormal_spinal_cord0.90679444
78MP0002063_abnormal_learning/memory/cond0.90594734
79MP0002572_abnormal_emotion/affect_behav0.90396742
80MP0003879_abnormal_hair_cell0.88970293
81MP0001963_abnormal_hearing_physiology0.88774496
82MP0002148_abnormal_hypersensitivity_rea0.86011649
83MP0001502_abnormal_circadian_rhythm0.84704915
84MP0009785_altered_susceptibility_to0.83673739
85MP0009333_abnormal_splenocyte_physiolog0.82471363
86MP0003635_abnormal_synaptic_transmissio0.81966492
87MP0004859_abnormal_synaptic_plasticity0.81237761
88MP0009053_abnormal_anal_canal0.80831557
89MP0002067_abnormal_sensory_capabilities0.78966227
90MP0003880_abnormal_central_pattern0.78367162
91MP0002160_abnormal_reproductive_system0.75330340
92MP0005084_abnormal_gallbladder_morpholo0.75077582
93MP0002735_abnormal_chemical_nociception0.74242820
94MP0002638_abnormal_pupillary_reflex0.74173085
95MP0002277_abnormal_respiratory_mucosa0.73042082
96MP0000427_abnormal_hair_cycle0.71255251
97MP0005381_digestive/alimentary_phenotyp0.70437743
98MP0000613_abnormal_salivary_gland0.69218845
99MP0004130_abnormal_muscle_cell0.69023407
100MP0005075_abnormal_melanosome_morpholog0.68559064

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.92886290
2Abnormality of cells of the erythroid lineage (HP:0012130)4.10572445
3Abnormality of midbrain morphology (HP:0002418)3.91861041
4Molar tooth sign on MRI (HP:0002419)3.91861041
5Pancreatic fibrosis (HP:0100732)3.85926894
6Acute necrotizing encephalopathy (HP:0006965)3.68269775
7Pancreatic cysts (HP:0001737)3.48313713
8Nephronophthisis (HP:0000090)3.42997294
9Septo-optic dysplasia (HP:0100842)3.35957438
10Abnormal number of erythroid precursors (HP:0012131)3.25227961
11Abnormal mitochondria in muscle tissue (HP:0008316)3.23373210
12Acute encephalopathy (HP:0006846)3.15227408
13Type II lissencephaly (HP:0007260)3.11366593
14True hermaphroditism (HP:0010459)3.07914213
15Macrocytic anemia (HP:0001972)3.05625823
16Mitochondrial inheritance (HP:0001427)3.04475725
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.99564949
18Progressive macrocephaly (HP:0004481)2.91697231
19Chronic hepatic failure (HP:0100626)2.79791962
20Increased IgM level (HP:0003496)2.79694619
21Congenital stationary night blindness (HP:0007642)2.78570390
22Abnormality of the renal medulla (HP:0100957)2.74759122
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.71954442
24Asplenia (HP:0001746)2.64926210
25Increased CSF lactate (HP:0002490)2.64773743
26Abnormal rod and cone electroretinograms (HP:0008323)2.63476143
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.58009566
28Absent/shortened dynein arms (HP:0200106)2.58009566
29Stomatitis (HP:0010280)2.56742994
30Hepatocellular necrosis (HP:0001404)2.56180550
31Optic disc pallor (HP:0000543)2.55970738
32Abnormality of DNA repair (HP:0003254)2.55723201
33Absent thumb (HP:0009777)2.54038415
34Pallor (HP:0000980)2.49730220
35Sclerocornea (HP:0000647)2.48779210
36Pendular nystagmus (HP:0012043)2.43110872
37IgG deficiency (HP:0004315)2.41481222
38Abolished electroretinogram (ERG) (HP:0000550)2.40852246
39Anencephaly (HP:0002323)2.40274869
40Medial flaring of the eyebrow (HP:0010747)2.37120979
41Optic nerve hypoplasia (HP:0000609)2.36105698
42Cystic liver disease (HP:0006706)2.34976351
43Rib fusion (HP:0000902)2.33277623
44Elevated erythrocyte sedimentation rate (HP:0003565)2.26773912
45Cerebral edema (HP:0002181)2.22067120
46Hepatic necrosis (HP:0002605)2.21883887
47Methylmalonic acidemia (HP:0002912)2.20252384
483-Methylglutaconic aciduria (HP:0003535)2.19111537
49Tubular atrophy (HP:0000092)2.17218113
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16867801
51Methylmalonic aciduria (HP:0012120)2.16347226
52Abnormality of the renal cortex (HP:0011035)2.16288356
53Abnormal ciliary motility (HP:0012262)2.16054096
54Abnormal respiratory motile cilium morphology (HP:0005938)2.14310291
55Abnormal respiratory epithelium morphology (HP:0012253)2.14310291
56Cerebellar dysplasia (HP:0007033)2.11529865
57Postaxial foot polydactyly (HP:0001830)2.09612527
58Maternal diabetes (HP:0009800)2.09006147
59Congenital hepatic fibrosis (HP:0002612)2.06503034
60Stenosis of the external auditory canal (HP:0000402)2.03063071
61Attenuation of retinal blood vessels (HP:0007843)2.03062595
62Pachygyria (HP:0001302)2.01331367
63Hypoplasia of the pons (HP:0012110)2.01292984
64Hypoplasia of the radius (HP:0002984)2.00574692
65Type 2 muscle fiber atrophy (HP:0003554)1.97795180
66Hypoproteinemia (HP:0003075)1.97201632
67Abnormality of the pons (HP:0007361)1.94615386
68Oligodactyly (hands) (HP:0001180)1.93633833
69Polydipsia (HP:0001959)1.93469669
70Abnormal drinking behavior (HP:0030082)1.93469669
71Hypoplasia of the ulna (HP:0003022)1.89057865
72Absent septum pellucidum (HP:0001331)1.88833049
73Abnormality of the 4th metacarpal (HP:0010012)1.87072322
74Abnormal respiratory motile cilium physiology (HP:0012261)1.86021141
75Forearm undergrowth (HP:0009821)1.84780024
76Increased corneal curvature (HP:0100692)1.84429345
77Keratoconus (HP:0000563)1.84429345
78Muscle fiber atrophy (HP:0100295)1.83660992
7911 pairs of ribs (HP:0000878)1.83013878
80Anophthalmia (HP:0000528)1.82820403
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79901922
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.79210781
83Depressed nasal ridge (HP:0000457)1.79026048
84Hyperglycinemia (HP:0002154)1.77966621
85Polyuria (HP:0000103)1.77702378
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77084234
87Myokymia (HP:0002411)1.76762664
88Agitation (HP:0000713)1.75938742
89Lipid accumulation in hepatocytes (HP:0006561)1.75765312
90Growth hormone deficiency (HP:0000824)1.75540874
91Decreased central vision (HP:0007663)1.70828855
92Lissencephaly (HP:0001339)1.69808207
93Increased hepatocellular lipid droplets (HP:0006565)1.68898966
94Abnormality of the aortic arch (HP:0012303)1.68518107
95Increased serum lactate (HP:0002151)1.68246179
96Aplasia/Hypoplasia of the ulna (HP:0006495)1.67585712
97Bony spicule pigmentary retinopathy (HP:0007737)1.66498896
98Neutropenia (HP:0001875)1.66257931
99Oligodactyly (HP:0012165)1.65805988
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.65255478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.90046992
2CDK193.42571581
3BCKDK3.32722540
4STK163.21543968
5TLK12.96819963
6SIK22.74105694
7WNK42.66659818
8ADRBK22.64948163
9TIE12.22862115
10BMPR1B2.14314567
11NUAK12.11049329
12GRK12.06682412
13FRK2.00511068
14MAP4K21.88487863
15ZAK1.84577206
16DYRK21.74559668
17PINK11.73720601
18MAP4K11.73102106
19CAMKK21.57631977
20PIK3CA1.51130312
21EPHB21.47095446
22TYRO31.46491449
23WNK31.43365033
24KDR1.37734491
25NTRK21.32366418
26MAP3K111.30625520
27TNK21.22589317
28MUSK1.20972295
29CAMK11.20170972
30NME11.19168807
31CAMKK11.17928433
32NEK21.16681116
33LRRK21.16241917
34NTRK31.12486907
35VRK21.12436317
36BTK1.03412995
37ADRBK11.03101557
38ITK1.03024148
39EPHA41.01276362
40PRKCG0.99924196
41MAP3K120.99820159
42CDK80.98757109
43PRKCQ0.97124661
44GRK60.96227029
45TEC0.95026316
46NEK10.95000798
47IKBKB0.92914696
48VRK10.87117329
49CASK0.84582608
50INSRR0.81872630
51DYRK1B0.81070662
52MAPK130.79743942
53MAP2K70.78497700
54MAP3K90.74947659
55DAPK30.74466413
56FES0.73510417
57RPS6KA60.72636558
58MARK30.67358597
59SYK0.67124808
60LIMK10.65900764
61STK110.65842028
62OXSR10.65787957
63PRKCH0.65741071
64TGFBR10.65652046
65PHKG10.65124091
66PHKG20.65124091
67PRKACA0.64630998
68PAK30.62948032
69CAMK1D0.60572090
70LCK0.59478823
71STK390.59055390
72IKBKE0.58369098
73PAK60.57160746
74TRIM280.56941618
75RPS6KA50.53775213
76CDC70.49800816
77WNK10.49599899
78LYN0.49387428
79PRKCA0.48151245
80TAOK30.47329145
81PRKCZ0.46717113
82DAPK20.46573730
83PKN10.46344641
84CSF1R0.46211375
85MAP2K20.45936780
86CAMK40.44987273
87MAPKAPK50.44278017
88CSNK2A20.43705453
89MAP2K60.43303733
90OBSCN0.42536843
91MAPK150.41861025
92RPS6KC10.41708724
93RPS6KL10.41708724
94AURKA0.40515143
95MAPKAPK30.38761577
96AURKB0.38748738
97CHUK0.37485482
98SGK10.36888283
99CSNK1A10.34811085
100PRKCE0.34690115

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.81192500
2Oxidative phosphorylation_Homo sapiens_hsa001903.42348341
3Parkinsons disease_Homo sapiens_hsa050122.79776187
4Asthma_Homo sapiens_hsa053102.74321413
5Allograft rejection_Homo sapiens_hsa053302.66658208
6Graft-versus-host disease_Homo sapiens_hsa053322.60149442
7Autoimmune thyroid disease_Homo sapiens_hsa053202.30143680
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.27175084
9Cardiac muscle contraction_Homo sapiens_hsa042602.24898212
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18388899
11Primary immunodeficiency_Homo sapiens_hsa053402.15358534
12Linoleic acid metabolism_Homo sapiens_hsa005912.15070077
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01846570
14Huntingtons disease_Homo sapiens_hsa050161.93616059
15Type I diabetes mellitus_Homo sapiens_hsa049401.86633653
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86439251
17Alzheimers disease_Homo sapiens_hsa050101.84342605
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81790232
19Phototransduction_Homo sapiens_hsa047441.77295352
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77158641
21Sulfur relay system_Homo sapiens_hsa041221.62201707
22RNA polymerase_Homo sapiens_hsa030201.60114188
23Proteasome_Homo sapiens_hsa030501.58741383
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46845149
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42246456
26Antigen processing and presentation_Homo sapiens_hsa046121.40304216
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40003817
28Nicotine addiction_Homo sapiens_hsa050331.38217484
29Homologous recombination_Homo sapiens_hsa034401.36919111
30RNA degradation_Homo sapiens_hsa030181.36605449
31Nitrogen metabolism_Homo sapiens_hsa009101.33244041
32Caffeine metabolism_Homo sapiens_hsa002321.31800725
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22612342
34Peroxisome_Homo sapiens_hsa041461.18993058
35Protein export_Homo sapiens_hsa030601.17846189
36Fanconi anemia pathway_Homo sapiens_hsa034601.17758323
37Rheumatoid arthritis_Homo sapiens_hsa053231.14170736
38Basal transcription factors_Homo sapiens_hsa030221.06368625
39Arachidonic acid metabolism_Homo sapiens_hsa005901.04452752
40Regulation of autophagy_Homo sapiens_hsa041401.04151586
41Hematopoietic cell lineage_Homo sapiens_hsa046401.02473086
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96717635
43Ether lipid metabolism_Homo sapiens_hsa005650.92108247
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90558324
45Butanoate metabolism_Homo sapiens_hsa006500.89050444
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87475400
47Olfactory transduction_Homo sapiens_hsa047400.82904127
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82826100
49One carbon pool by folate_Homo sapiens_hsa006700.82658599
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82415280
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81047600
52Propanoate metabolism_Homo sapiens_hsa006400.80539665
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.78977904
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77258646
55Chemical carcinogenesis_Homo sapiens_hsa052040.76126370
56Fat digestion and absorption_Homo sapiens_hsa049750.72275524
57Morphine addiction_Homo sapiens_hsa050320.71464967
58Tryptophan metabolism_Homo sapiens_hsa003800.71367765
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70708901
60Pyrimidine metabolism_Homo sapiens_hsa002400.70129462
61T cell receptor signaling pathway_Homo sapiens_hsa046600.60197537
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57604677
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.56750931
64Glycerolipid metabolism_Homo sapiens_hsa005610.54865918
65Retinol metabolism_Homo sapiens_hsa008300.53037936
66Ovarian steroidogenesis_Homo sapiens_hsa049130.52552455
67Metabolic pathways_Homo sapiens_hsa011000.52426081
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50882722
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50330411
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48142459
71Taste transduction_Homo sapiens_hsa047420.47114098
72Viral myocarditis_Homo sapiens_hsa054160.45004410
73Collecting duct acid secretion_Homo sapiens_hsa049660.44165759
74Purine metabolism_Homo sapiens_hsa002300.43370604
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42731222
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41997757
77Glutamatergic synapse_Homo sapiens_hsa047240.41854097
78Insulin secretion_Homo sapiens_hsa049110.39664467
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39550006
80Vitamin digestion and absorption_Homo sapiens_hsa049770.38255463
81Steroid biosynthesis_Homo sapiens_hsa001000.37748330
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37741100
83Basal cell carcinoma_Homo sapiens_hsa052170.34930788
84Nucleotide excision repair_Homo sapiens_hsa034200.34302535
85Systemic lupus erythematosus_Homo sapiens_hsa053220.33325002
86Serotonergic synapse_Homo sapiens_hsa047260.31787232
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.30898866
88GABAergic synapse_Homo sapiens_hsa047270.30697941
89Hedgehog signaling pathway_Homo sapiens_hsa043400.28844406
90Salivary secretion_Homo sapiens_hsa049700.27821567
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27066606
92Axon guidance_Homo sapiens_hsa043600.26316077
93Oxytocin signaling pathway_Homo sapiens_hsa049210.26008689
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.25961843
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25181450
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.24664976
97Staphylococcus aureus infection_Homo sapiens_hsa051500.24224835
98ABC transporters_Homo sapiens_hsa020100.23817524
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23649940
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22921279

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