RPS27P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.73810694
2translational termination (GO:0006415)7.37915985
3ribosomal small subunit biogenesis (GO:0042274)7.30922972
4maturation of SSU-rRNA (GO:0030490)7.29884294
5ribosomal small subunit assembly (GO:0000028)7.14822308
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.17417666
7translational elongation (GO:0006414)6.09549094
8cotranslational protein targeting to membrane (GO:0006613)6.08947013
9protein targeting to ER (GO:0045047)6.05505141
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.82617307
11protein localization to endoplasmic reticulum (GO:0070972)5.71125449
12viral life cycle (GO:0019058)5.57696510
13cellular protein complex disassembly (GO:0043624)5.57353789
14behavioral response to nicotine (GO:0035095)5.49607039
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.26683929
16ATP synthesis coupled proton transport (GO:0015986)5.23871662
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.23871662
18protein complex disassembly (GO:0043241)4.69227604
19translational initiation (GO:0006413)4.64099980
20chaperone-mediated protein transport (GO:0072321)4.49387922
21macromolecular complex disassembly (GO:0032984)4.40924937
22ribosomal large subunit biogenesis (GO:0042273)4.39266050
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37585187
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.33278996
25substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.28312419
26substrate-independent telencephalic tangential migration (GO:0021826)4.28312419
27protein neddylation (GO:0045116)4.27386588
28protein targeting to membrane (GO:0006612)4.18285328
29nonmotile primary cilium assembly (GO:0035058)3.87950890
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.82643525
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78263891
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.77174647
33negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76669714
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70048649
35regulation of cilium movement (GO:0003352)3.60152968
36mRNA catabolic process (GO:0006402)3.56127273
37translation (GO:0006412)3.55317198
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.48758417
39NADH dehydrogenase complex assembly (GO:0010257)3.48758417
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48758417
41cell proliferation in forebrain (GO:0021846)3.47977193
42protein complex biogenesis (GO:0070271)3.46536927
43electron transport chain (GO:0022900)3.38224469
44epithelial cilium movement (GO:0003351)3.37042724
45respiratory electron transport chain (GO:0022904)3.34154508
46cellular component biogenesis (GO:0044085)3.21832951
47DNA deamination (GO:0045006)3.20884498
48RNA catabolic process (GO:0006401)3.19589974
49ribonucleoprotein complex biogenesis (GO:0022613)3.19520186
50rRNA catabolic process (GO:0016075)3.19030301
51tongue development (GO:0043586)3.18201576
52somite development (GO:0061053)3.10764901
53ATP biosynthetic process (GO:0006754)3.08298566
54negative regulation of response to food (GO:0032096)3.08015490
55negative regulation of appetite (GO:0032099)3.08015490
56synaptic transmission, cholinergic (GO:0007271)3.07841369
57preassembly of GPI anchor in ER membrane (GO:0016254)3.07006061
58positive regulation of respiratory burst (GO:0060267)3.03875512
59hypothalamus development (GO:0021854)3.03659779
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02203044
61mitochondrial respiratory chain complex assembly (GO:0033108)2.99624627
62negative regulation of DNA-templated transcription, elongation (GO:0032785)2.98840393
63regulation of microtubule-based movement (GO:0060632)2.97640118
64purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96170031
65axoneme assembly (GO:0035082)2.90648069
66parturition (GO:0007567)2.86954999
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84038197
68neuron fate determination (GO:0048664)2.82904806
69GTP biosynthetic process (GO:0006183)2.82900555
70endoderm formation (GO:0001706)2.80934424
71regulation of immunoglobulin secretion (GO:0051023)2.79615572
72protein polyglutamylation (GO:0018095)2.79194803
73establishment of protein localization to membrane (GO:0090150)2.76169631
74intraciliary transport (GO:0042073)2.74008326
75hydrogen ion transmembrane transport (GO:1902600)2.73955598
76cilium movement (GO:0003341)2.71696370
77response to redox state (GO:0051775)2.71162207
78protein localization to cilium (GO:0061512)2.70911991
79positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.69982829
80negative regulation of telomere maintenance (GO:0032205)2.69082325
81protein targeting (GO:0006605)2.61658264
82piRNA metabolic process (GO:0034587)2.60361310
83axonemal dynein complex assembly (GO:0070286)2.59577035
84GPI anchor metabolic process (GO:0006505)2.58983049
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58071773
86pattern specification involved in kidney development (GO:0061004)2.56317572
87ribonucleoside triphosphate biosynthetic process (GO:0009201)2.56060201
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54979542
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54979542
90auditory receptor cell differentiation (GO:0042491)2.54155370
91pyrimidine nucleobase catabolic process (GO:0006208)2.54005633
92negative regulation of heart rate (GO:0010459)2.51100466
93protein-cofactor linkage (GO:0018065)2.50568177
94regulation of action potential (GO:0098900)2.49841588
95positive regulation of T cell apoptotic process (GO:0070234)2.48821399
96head development (GO:0060322)2.48697866
97proton transport (GO:0015992)2.48520609
98spinal cord association neuron differentiation (GO:0021527)2.48187614
99negative regulation of mast cell activation (GO:0033004)2.44429169
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43787981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.49126314
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80715167
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77130777
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.71118431
5ZNF274_21170338_ChIP-Seq_K562_Hela2.41158862
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30623047
7VDR_22108803_ChIP-Seq_LS180_Human2.29438096
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28311712
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13469227
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.08045625
11IRF1_19129219_ChIP-ChIP_H3396_Human1.89583653
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87101669
13EST1_17652178_ChIP-ChIP_JURKAT_Human1.86336258
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83001163
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.81962987
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.81642462
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79081053
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76361575
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73765431
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.65029309
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.63541787
22TP53_22573176_ChIP-Seq_HFKS_Human1.62043659
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61102038
24REST_21632747_ChIP-Seq_MESCs_Mouse1.57284875
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54047676
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.50334424
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50189182
28MYC_18940864_ChIP-ChIP_HL60_Human1.48583865
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47146531
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46985552
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46348487
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43585545
33RNF2_27304074_Chip-Seq_NSC_Mouse1.40781675
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.40546106
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38351737
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38106081
37TAF2_19829295_ChIP-Seq_ESCs_Human1.37892589
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.36987602
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36195555
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33050417
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32167108
42ERA_21632823_ChIP-Seq_H3396_Human1.32118252
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29743364
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.28688883
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28448258
46CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26885437
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26401316
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.25906390
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24626218
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24455711
51NANOG_20526341_ChIP-Seq_ESCs_Human1.23518441
52NCOR_22424771_ChIP-Seq_293T_Human1.22606648
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21099737
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20576057
55VDR_23849224_ChIP-Seq_CD4+_Human1.20491358
56TTF2_22483619_ChIP-Seq_HELA_Human1.19629744
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19352297
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18333655
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16281847
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15509870
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15509870
62IGF1R_20145208_ChIP-Seq_DFB_Human1.14855295
63EWS_26573619_Chip-Seq_HEK293_Human1.11037868
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10845092
65ELK1_19687146_ChIP-ChIP_HELA_Human1.10748000
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10672105
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06983809
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06691763
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.03505623
70P300_19829295_ChIP-Seq_ESCs_Human1.02221861
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02055358
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.00618733
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00618733
74BCL6_27268052_Chip-Seq_Bcells_Human1.00167014
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99087367
76FOXH1_21741376_ChIP-Seq_ESCs_Human0.98575588
77MYC_19829295_ChIP-Seq_ESCs_Human0.98101691
78TP53_20018659_ChIP-ChIP_R1E_Mouse0.97978203
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97613875
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96669750
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96669750
82TP63_19390658_ChIP-ChIP_HaCaT_Human0.96315663
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95353568
84CBP_20019798_ChIP-Seq_JUKART_Human0.95353568
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95045355
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93955243
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93854107
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92528918
89P53_21459846_ChIP-Seq_SAOS-2_Human0.92021516
90NANOG_19829295_ChIP-Seq_ESCs_Human0.91447604
91SOX2_19829295_ChIP-Seq_ESCs_Human0.91447604
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89925544
93CTCF_27219007_Chip-Seq_Bcells_Human0.89802679
94CTCF_20526341_ChIP-Seq_ESCs_Human0.88585212
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.88302704
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.88196987
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87347112
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87334081
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.86727157
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85894331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.41617066
2MP0006292_abnormal_olfactory_placode4.48246123
3MP0008877_abnormal_DNA_methylation3.05486812
4MP0003787_abnormal_imprinting3.02642541
5MP0008789_abnormal_olfactory_epithelium2.86055815
6MP0004142_abnormal_muscle_tone2.61400835
7MP0003878_abnormal_ear_physiology2.59333779
8MP0005377_hearing/vestibular/ear_phenot2.59333779
9MP0005499_abnormal_olfactory_system2.36337335
10MP0005394_taste/olfaction_phenotype2.36337335
11MP0002653_abnormal_ependyma_morphology2.22704173
12MP0004885_abnormal_endolymph2.19258413
13MP0003123_paternal_imprinting2.06115638
14MP0001348_abnormal_lacrimal_gland1.97215481
15MP0003646_muscle_fatigue1.96006135
16MP0003122_maternal_imprinting1.95628941
17MP0002163_abnormal_gland_morphology1.95496973
18MP0002102_abnormal_ear_morphology1.76895597
19MP0005671_abnormal_response_to1.73679646
20MP0002138_abnormal_hepatobiliary_system1.70690907
21MP0003121_genomic_imprinting1.68557521
22MP0005551_abnormal_eye_electrophysiolog1.67176282
23MP0006276_abnormal_autonomic_nervous1.65186968
24MP0001984_abnormal_olfaction1.64571238
25MP0001485_abnormal_pinna_reflex1.61688400
26MP0001986_abnormal_taste_sensitivity1.61646237
27MP0002876_abnormal_thyroid_physiology1.54843204
28MP0001293_anophthalmia1.54616951
29MP0008872_abnormal_physiological_respon1.51450397
30MP0006072_abnormal_retinal_apoptosis1.51089903
31MP0002272_abnormal_nervous_system1.48700568
32MP0000049_abnormal_middle_ear1.39586748
33MP0001968_abnormal_touch/_nociception1.37618259
34MP0003879_abnormal_hair_cell1.36973629
35MP0004147_increased_porphyrin_level1.36536090
36MP0003011_delayed_dark_adaptation1.34110826
37MP0000372_irregular_coat_pigmentation1.33436894
38MP0000778_abnormal_nervous_system1.29927480
39MP0002638_abnormal_pupillary_reflex1.28682839
40MP0001835_abnormal_antigen_presentation1.27822703
41MP0004742_abnormal_vestibular_system1.25992204
42MP0002095_abnormal_skin_pigmentation1.25869817
43MP0003136_yellow_coat_color1.25742702
44MP0004133_heterotaxia1.24540489
45MP0000026_abnormal_inner_ear1.24155549
46MP0003880_abnormal_central_pattern1.23982904
47MP0009745_abnormal_behavioral_response1.21192898
48MP0002938_white_spotting1.20182398
49MP0001188_hyperpigmentation1.20139066
50MP0001440_abnormal_grooming_behavior1.19956887
51MP0008875_abnormal_xenobiotic_pharmacok1.17431260
52MP0005195_abnormal_posterior_eye1.17242410
53MP0001905_abnormal_dopamine_level1.15306871
54MP0001529_abnormal_vocalization1.14563944
55MP0004145_abnormal_muscle_electrophysio1.13486081
56MP0005174_abnormal_tail_pigmentation1.12777424
57MP0002557_abnormal_social/conspecific_i1.09148294
58MP0002752_abnormal_somatic_nervous1.07637550
59MP0000631_abnormal_neuroendocrine_gland1.06859067
60MP0005253_abnormal_eye_physiology1.06743216
61MP0002837_dystrophic_cardiac_calcinosis1.06453273
62MP0005379_endocrine/exocrine_gland_phen1.06114687
63MP0001970_abnormal_pain_threshold1.05035735
64MP0001963_abnormal_hearing_physiology1.04241189
65MP0002234_abnormal_pharynx_morphology1.04126954
66MP0001486_abnormal_startle_reflex1.02153945
67MP0001502_abnormal_circadian_rhythm1.01175341
68MP0002184_abnormal_innervation1.00187168
69MP0002736_abnormal_nociception_after0.98490189
70MP0010030_abnormal_orbit_morphology0.97269398
71MP0005646_abnormal_pituitary_gland0.96290070
72MP0004043_abnormal_pH_regulation0.95865066
73MP0002572_abnormal_emotion/affect_behav0.95718884
74MP0009046_muscle_twitch0.94725015
75MP0002063_abnormal_learning/memory/cond0.93442947
76MP0000427_abnormal_hair_cycle0.92965263
77MP0002734_abnormal_mechanical_nocicepti0.89736656
78MP0005084_abnormal_gallbladder_morpholo0.88182984
79MP0003186_abnormal_redox_activity0.88042382
80MP0001919_abnormal_reproductive_system0.85440015
81MP0000955_abnormal_spinal_cord0.85153552
82MP0005389_reproductive_system_phenotype0.84882990
83MP0009764_decreased_sensitivity_to0.84573290
84MP0002733_abnormal_thermal_nociception0.84284244
85MP0001800_abnormal_humoral_immune0.83926450
86MP0002233_abnormal_nose_morphology0.82346920
87MP0000230_abnormal_systemic_arterial0.81932656
88MP0003938_abnormal_ear_development0.79462545
89MP0005423_abnormal_somatic_nervous0.79338895
90MP0003635_abnormal_synaptic_transmissio0.78701575
91MP0008775_abnormal_heart_ventricle0.78150383
92MP0001324_abnormal_eye_pigmentation0.74600768
93MP0002882_abnormal_neuron_morphology0.72665475
94MP0005075_abnormal_melanosome_morpholog0.72469237
95MP0002229_neurodegeneration0.72313318
96MP0000685_abnormal_immune_system0.70585310
97MP0002067_abnormal_sensory_capabilities0.69736133
98MP0002160_abnormal_reproductive_system0.69014184
99MP0002064_seizures0.67021310
100MP0005645_abnormal_hypothalamus_physiol0.66307374

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.30339055
2Abnormality of cells of the erythroid lineage (HP:0012130)4.62887307
3Molar tooth sign on MRI (HP:0002419)4.26074976
4Abnormality of midbrain morphology (HP:0002418)4.26074976
5Macrocytic anemia (HP:0001972)3.74470628
6Acute necrotizing encephalopathy (HP:0006965)3.66569400
7Pallor (HP:0000980)3.45409650
8Medial flaring of the eyebrow (HP:0010747)3.35152853
9Pancreatic fibrosis (HP:0100732)3.31460638
10Congenital stationary night blindness (HP:0007642)3.23578388
11Acute encephalopathy (HP:0006846)3.16245758
12Rib fusion (HP:0000902)3.13602992
13Abnormal mitochondria in muscle tissue (HP:0008316)3.12364739
14Abnormal hemoglobin (HP:0011902)3.12241579
15Mitochondrial inheritance (HP:0001427)3.08774054
16Abnormal number of erythroid precursors (HP:0012131)3.08549951
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.02515032
18Absent/shortened dynein arms (HP:0200106)3.02515032
19Nephronophthisis (HP:0000090)2.98679842
20Septo-optic dysplasia (HP:0100842)2.96327855
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92015128
22Gait imbalance (HP:0002141)2.86863508
23Progressive macrocephaly (HP:0004481)2.84730064
24Pancreatic cysts (HP:0001737)2.84236096
25Abnormal rod and cone electroretinograms (HP:0008323)2.80099675
26Increased CSF lactate (HP:0002490)2.79211144
27Congenital primary aphakia (HP:0007707)2.71639634
28Stenosis of the external auditory canal (HP:0000402)2.68896592
29Pendular nystagmus (HP:0012043)2.66428490
30IgG deficiency (HP:0004315)2.64732052
31Absent thumb (HP:0009777)2.61107321
32Type II lissencephaly (HP:0007260)2.60306080
33Nephrogenic diabetes insipidus (HP:0009806)2.54868920
343-Methylglutaconic aciduria (HP:0003535)2.52460815
35Lipid accumulation in hepatocytes (HP:0006561)2.49151359
36Abnormal ciliary motility (HP:0012262)2.48670224
37Cerebral edema (HP:0002181)2.42691255
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41912468
39Abnormality of DNA repair (HP:0003254)2.41250490
40True hermaphroditism (HP:0010459)2.40500173
41Increased hepatocellular lipid droplets (HP:0006565)2.40380723
42Abolished electroretinogram (ERG) (HP:0000550)2.40111752
43Hypoplasia of the ulna (HP:0003022)2.39442253
44Abnormal respiratory motile cilium morphology (HP:0005938)2.37274264
45Abnormal respiratory epithelium morphology (HP:0012253)2.37274264
46Stomatitis (HP:0010280)2.35804017
47Hypoplasia of the radius (HP:0002984)2.34990317
48Abnormality of the renal medulla (HP:0100957)2.33922141
49Abnormal drinking behavior (HP:0030082)2.32649200
50Polydipsia (HP:0001959)2.32649200
51Asplenia (HP:0001746)2.29579603
52Optic disc pallor (HP:0000543)2.27540353
53Hyperglycinemia (HP:0002154)2.26128904
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.24916305
55Sclerocornea (HP:0000647)2.21821277
56Hepatocellular necrosis (HP:0001404)2.21431812
57Supernumerary spleens (HP:0009799)2.17992578
58Type 2 muscle fiber atrophy (HP:0003554)2.17027702
59Forearm undergrowth (HP:0009821)2.16937920
60Optic nerve hypoplasia (HP:0000609)2.16383449
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13010537
62Renal Fanconi syndrome (HP:0001994)2.12168347
63Colon cancer (HP:0003003)2.10318114
64Postaxial foot polydactyly (HP:0001830)2.05881083
65Abnormal respiratory motile cilium physiology (HP:0012261)2.04172821
66Chronic hepatic failure (HP:0100626)2.03072468
67Growth hormone deficiency (HP:0000824)2.02511168
68Absent septum pellucidum (HP:0001331)2.01560224
69Depressed nasal ridge (HP:0000457)2.01232518
70Agitation (HP:0000713)2.00902177
71Abnormal biliary tract physiology (HP:0012439)2.00080245
72Bile duct proliferation (HP:0001408)2.00080245
73Poor coordination (HP:0002370)1.98535373
74Aplasia/Hypoplasia of the ulna (HP:0006495)1.98145756
75Tubular atrophy (HP:0000092)1.96415411
76Anencephaly (HP:0002323)1.96350006
77Decreased central vision (HP:0007663)1.95697212
78Abnormality of the labia minora (HP:0012880)1.94239622
79Adrenal hypoplasia (HP:0000835)1.93830297
80Vaginal atresia (HP:0000148)1.93351362
81Increased intramyocellular lipid droplets (HP:0012240)1.92980229
82Cystic liver disease (HP:0006706)1.92740337
83Congenital, generalized hypertrichosis (HP:0004540)1.92104922
84Myokymia (HP:0002411)1.92005084
85Increased IgM level (HP:0003496)1.90720372
86Abnormality of the diencephalon (HP:0010662)1.88029132
87Genital tract atresia (HP:0001827)1.87564879
88Postaxial hand polydactyly (HP:0001162)1.84224713
89Hepatic necrosis (HP:0002605)1.82838068
90Elevated erythrocyte sedimentation rate (HP:0003565)1.79124157
91Abnormality of the phalanges of the 5th finger (HP:0004213)1.77941686
92Muscle fiber atrophy (HP:0100295)1.77915285
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77050968
94Porencephaly (HP:0002132)1.76979948
95Polyuria (HP:0000103)1.76965682
96Abnormality of the renal cortex (HP:0011035)1.76083708
97Increased muscle lipid content (HP:0009058)1.75774064
98Polyphagia (HP:0002591)1.74192515
99Partial duplication of thumb phalanx (HP:0009944)1.73698802
100Thyroid-stimulating hormone excess (HP:0002925)1.71520477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.69317186
2WNK43.27583513
3TLK12.86119064
4CDK192.72150576
5TXK2.66318230
6ADRBK22.65058025
7PINK12.58233237
8BCKDK2.52503110
9GRK12.30161022
10PIK3CA2.27001061
11MUSK2.21824593
12ZAK2.19914542
13STK162.08515193
14MAP4K21.95755891
15DYRK21.95027976
16BMPR1B1.84576128
17NTRK21.78339404
18GRK61.76808046
19TIE11.69792521
20EPHB21.64163089
21MAP3K41.63736367
22BMPR21.58258816
23STK391.48941245
24MAP3K91.45603284
25NUAK11.41312740
26CASK1.38422590
27OXSR11.28675424
28MAP3K121.28608499
29MAP2K21.28370594
30MAP2K71.11318777
31TYRO31.10076300
32PRKCG1.01276252
33IKBKB0.99752726
34ARAF0.98491219
35CAMK10.98404101
36BTK0.97670818
37FRK0.94328160
38LRRK20.92216333
39PAK30.90134349
40WNK30.89527467
41CDC70.89207422
42FES0.87782665
43MAPK130.87241155
44EPHA40.83569088
45MAP4K10.82690371
46PRKCQ0.82118907
47ADRBK10.82093318
48INSRR0.79636589
49TEC0.79445145
50DAPK30.77494395
51NTRK10.76290203
52WNK10.76079312
53RPS6KA60.74274943
54BRAF0.71258491
55ITK0.71139119
56MAPK150.70277321
57CAMKK10.69367761
58STK110.67550882
59PRKACA0.64725730
60NTRK30.62043389
61PHKG10.61709956
62PHKG20.61709956
63CDK80.60617204
64MAP3K110.59723170
65DYRK1B0.59653729
66CSNK2A20.59392035
67MATK0.58976737
68DYRK30.57503315
69NEK20.56719483
70NME10.55154320
71MARK10.54357179
72VRK10.53463254
73RPS6KL10.52840710
74RPS6KC10.52840710
75SYK0.52381238
76RPS6KA50.51329136
77SGK2230.49152111
78SGK4940.49152111
79PIM10.49077263
80MYLK0.48948872
81ABL20.48262741
82PRKCH0.48153039
83MAP2K40.47115509
84AURKB0.45313102
85KIT0.45012251
86OBSCN0.44699341
87PIM20.42079662
88PKN10.41709673
89LIMK10.41593521
90RPS6KA20.40232018
91LYN0.40097035
92PRKCA0.39632101
93PASK0.39352663
94AURKA0.38946823
95PLK10.38540594
96PRKCI0.38403635
97DAPK20.38017836
98PRKCD0.36722236
99LCK0.36218572
100IKBKE0.34375311

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.14868607
2Oxidative phosphorylation_Homo sapiens_hsa001903.95069576
3Asthma_Homo sapiens_hsa053103.94034526
4Parkinsons disease_Homo sapiens_hsa050123.22017208
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.13181308
6Allograft rejection_Homo sapiens_hsa053302.85043668
7Cardiac muscle contraction_Homo sapiens_hsa042602.82416590
8Autoimmune thyroid disease_Homo sapiens_hsa053202.69978306
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56820989
10Graft-versus-host disease_Homo sapiens_hsa053322.41449435
11Huntingtons disease_Homo sapiens_hsa050162.33731058
12Alzheimers disease_Homo sapiens_hsa050102.24518172
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11069681
14Protein export_Homo sapiens_hsa030601.90356781
15Linoleic acid metabolism_Homo sapiens_hsa005911.88232390
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81608801
17Type I diabetes mellitus_Homo sapiens_hsa049401.75603803
18Phototransduction_Homo sapiens_hsa047441.68516050
19Nicotine addiction_Homo sapiens_hsa050331.61900724
20RNA polymerase_Homo sapiens_hsa030201.60225021
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54448069
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52290803
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46261432
24Primary immunodeficiency_Homo sapiens_hsa053401.41976875
25Proteasome_Homo sapiens_hsa030501.35957348
26RNA degradation_Homo sapiens_hsa030181.35462193
27Basal transcription factors_Homo sapiens_hsa030221.32818638
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27453396
29Rheumatoid arthritis_Homo sapiens_hsa053230.92700344
30Homologous recombination_Homo sapiens_hsa034400.89711247
31Morphine addiction_Homo sapiens_hsa050320.88718414
32Caffeine metabolism_Homo sapiens_hsa002320.88267675
33Viral myocarditis_Homo sapiens_hsa054160.87076630
34Nitrogen metabolism_Homo sapiens_hsa009100.86380927
35Arachidonic acid metabolism_Homo sapiens_hsa005900.85173521
36Fat digestion and absorption_Homo sapiens_hsa049750.82787807
37Antigen processing and presentation_Homo sapiens_hsa046120.82032435
38Fanconi anemia pathway_Homo sapiens_hsa034600.80461264
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76392285
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76339172
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74918272
42Olfactory transduction_Homo sapiens_hsa047400.74451567
43Tryptophan metabolism_Homo sapiens_hsa003800.74178313
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.73205620
45Peroxisome_Homo sapiens_hsa041460.70944215
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70060364
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69819474
48Ether lipid metabolism_Homo sapiens_hsa005650.68735472
49Sulfur relay system_Homo sapiens_hsa041220.67784644
50Hematopoietic cell lineage_Homo sapiens_hsa046400.66066570
51Chemical carcinogenesis_Homo sapiens_hsa052040.65475653
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63924425
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63782033
54Propanoate metabolism_Homo sapiens_hsa006400.60695917
55Nucleotide excision repair_Homo sapiens_hsa034200.58804662
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.58257364
57Regulation of autophagy_Homo sapiens_hsa041400.57879410
58GABAergic synapse_Homo sapiens_hsa047270.57084979
59Insulin secretion_Homo sapiens_hsa049110.55172127
60Butanoate metabolism_Homo sapiens_hsa006500.54358424
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53650232
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52749839
63Systemic lupus erythematosus_Homo sapiens_hsa053220.49169133
64One carbon pool by folate_Homo sapiens_hsa006700.48236368
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48139232
66Pyrimidine metabolism_Homo sapiens_hsa002400.47553847
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47539298
68Retinol metabolism_Homo sapiens_hsa008300.47507655
69Metabolic pathways_Homo sapiens_hsa011000.47330757
70T cell receptor signaling pathway_Homo sapiens_hsa046600.46766756
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45196413
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44484148
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43019676
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42736050
75Staphylococcus aureus infection_Homo sapiens_hsa051500.41803412
76Serotonergic synapse_Homo sapiens_hsa047260.41399509
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40824134
78Basal cell carcinoma_Homo sapiens_hsa052170.38017904
79Ovarian steroidogenesis_Homo sapiens_hsa049130.36796800
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34552260
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.32327665
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31641512
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31195268
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30807607
85Circadian entrainment_Homo sapiens_hsa047130.30405667
86Purine metabolism_Homo sapiens_hsa002300.29544986
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28984630
88Glutamatergic synapse_Homo sapiens_hsa047240.28710865
89Salivary secretion_Homo sapiens_hsa049700.28002658
90Leishmaniasis_Homo sapiens_hsa051400.26629667
91Taste transduction_Homo sapiens_hsa047420.25966411
92Spliceosome_Homo sapiens_hsa030400.25715325
93Steroid biosynthesis_Homo sapiens_hsa001000.25259511
94Glycerolipid metabolism_Homo sapiens_hsa005610.20498412
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19082567
96RNA transport_Homo sapiens_hsa030130.18521321
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17639937
98Oxytocin signaling pathway_Homo sapiens_hsa049210.14772224
99Axon guidance_Homo sapiens_hsa043600.14732180
100Collecting duct acid secretion_Homo sapiens_hsa049660.14435965

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