RPS27P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.27624055
2viral transcription (GO:0019083)6.89851497
3translational termination (GO:0006415)6.56080297
4ribosomal small subunit biogenesis (GO:0042274)6.11125839
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.74307155
6protein targeting to ER (GO:0045047)5.67551924
7cotranslational protein targeting to membrane (GO:0006613)5.66947915
8maturation of SSU-rRNA (GO:0030490)5.62439683
9translational elongation (GO:0006414)5.61828649
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.39960782
11protein localization to endoplasmic reticulum (GO:0070972)5.37121632
12substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.14653306
13substrate-independent telencephalic tangential migration (GO:0021826)5.14653306
14viral life cycle (GO:0019058)5.07837061
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.05174539
16cellular protein complex disassembly (GO:0043624)4.99607586
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.77107623
18behavioral response to nicotine (GO:0035095)4.69097091
19protein neddylation (GO:0045116)4.54935162
20somite development (GO:0061053)4.46995715
21negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.46282261
22protein complex disassembly (GO:0043241)4.30346355
23ATP synthesis coupled proton transport (GO:0015986)4.21248210
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21248210
25translational initiation (GO:0006413)4.20004017
26macromolecular complex disassembly (GO:0032984)4.04807192
27water-soluble vitamin biosynthetic process (GO:0042364)3.96269459
28protein complex biogenesis (GO:0070271)3.88694374
29protein targeting to membrane (GO:0006612)3.88267796
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.83432351
31NADH dehydrogenase complex assembly (GO:0010257)3.83432351
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83432351
33GTP biosynthetic process (GO:0006183)3.80593981
34mitochondrial respiratory chain complex assembly (GO:0033108)3.77747484
35protein polyglutamylation (GO:0018095)3.76137168
36negative regulation of DNA-templated transcription, elongation (GO:0032785)3.72074479
37chaperone-mediated protein transport (GO:0072321)3.70971353
38axon ensheathment in central nervous system (GO:0032291)3.65234014
39central nervous system myelination (GO:0022010)3.65234014
40cell proliferation in forebrain (GO:0021846)3.64115049
41nonmotile primary cilium assembly (GO:0035058)3.63996179
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.55368128
43response to pheromone (GO:0019236)3.54093158
44translation (GO:0006412)3.47842082
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45698190
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44470684
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44345828
48neuron fate determination (GO:0048664)3.41559760
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38553377
50negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.37686146
51mRNA catabolic process (GO:0006402)3.36838387
52radial glial cell differentiation (GO:0060019)3.35652958
53tongue development (GO:0043586)3.35149976
54epithelial cilium movement (GO:0003351)3.34394010
55nephron tubule morphogenesis (GO:0072078)3.29946928
56nephron epithelium morphogenesis (GO:0072088)3.29946928
57ribosomal large subunit biogenesis (GO:0042273)3.29281599
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28746615
59rRNA catabolic process (GO:0016075)3.28042584
60base-excision repair, AP site formation (GO:0006285)3.25487675
61UTP biosynthetic process (GO:0006228)3.17369245
62regulation of chronic inflammatory response (GO:0002676)3.16037568
63DNA deamination (GO:0045006)3.13370314
64cellular component biogenesis (GO:0044085)3.12519870
65positive regulation of organelle assembly (GO:1902117)3.12443176
66respiratory electron transport chain (GO:0022904)3.08433228
67regulation of immunoglobulin secretion (GO:0051023)3.08413080
68electron transport chain (GO:0022900)3.07498444
69UTP metabolic process (GO:0046051)3.03820770
70RNA catabolic process (GO:0006401)3.00017834
71axonemal dynein complex assembly (GO:0070286)2.98737206
72intraciliary transport (GO:0042073)2.98673912
73pyrimidine nucleobase catabolic process (GO:0006208)2.98302546
74regulation of isotype switching to IgG isotypes (GO:0048302)2.96240600
75motile cilium assembly (GO:0044458)2.94269254
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93316420
77platelet dense granule organization (GO:0060155)2.92768071
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.91305296
79ribonucleoprotein complex biogenesis (GO:0022613)2.90355143
80purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85249375
81pattern specification involved in kidney development (GO:0061004)2.82732621
82negative regulation of telomere maintenance (GO:0032205)2.79881023
83cellular response to interferon-beta (GO:0035458)2.78544923
84pyrimidine nucleotide catabolic process (GO:0006244)2.76142179
85hydrogen ion transmembrane transport (GO:1902600)2.74415157
86resolution of meiotic recombination intermediates (GO:0000712)2.74293505
87parturition (GO:0007567)2.70778181
88L-fucose catabolic process (GO:0042355)2.66699406
89fucose catabolic process (GO:0019317)2.66699406
90L-fucose metabolic process (GO:0042354)2.66699406
91ATP biosynthetic process (GO:0006754)2.65755085
92replication fork processing (GO:0031297)2.65059633
93regulation of cilium movement (GO:0003352)2.65012249
94respiratory chain complex IV assembly (GO:0008535)2.62998550
95proton transport (GO:0015992)2.61816127
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59674900
97positive regulation of prostaglandin secretion (GO:0032308)2.59505261
98regulation of action potential (GO:0098900)2.58115274
99segment specification (GO:0007379)2.58000163
100positive regulation of fatty acid transport (GO:2000193)2.57864487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88486508
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82132111
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.45351732
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06153092
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97738284
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87410627
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.77783399
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.65517792
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.61183960
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38998814
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29958972
12ZNF274_21170338_ChIP-Seq_K562_Hela2.25202037
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07991364
14IRF1_19129219_ChIP-ChIP_H3396_Human1.92808826
15VDR_22108803_ChIP-Seq_LS180_Human1.68631861
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.66906029
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.62601446
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57136774
19REST_21632747_ChIP-Seq_MESCs_Mouse1.57045565
20VDR_23849224_ChIP-Seq_CD4+_Human1.56637081
21YY1_21170310_ChIP-Seq_MESCs_Mouse1.53781679
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52489946
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52076033
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.50705916
25FOXP3_21729870_ChIP-Seq_TREG_Human1.50662002
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.49630082
27MYC_18940864_ChIP-ChIP_HL60_Human1.48931542
28SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.46667746
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46357147
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45173278
31ELK1_19687146_ChIP-ChIP_HELA_Human1.43853412
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43681581
33TTF2_22483619_ChIP-Seq_HELA_Human1.43095917
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41896534
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40911274
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38575389
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37625401
38NANOG_20526341_ChIP-Seq_ESCs_Human1.37371615
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36135737
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35207890
41ERA_21632823_ChIP-Seq_H3396_Human1.32906252
42TP53_22573176_ChIP-Seq_HFKS_Human1.32636481
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.32532939
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30442479
45TAF2_19829295_ChIP-Seq_ESCs_Human1.29776822
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29020588
47FUS_26573619_Chip-Seq_HEK293_Human1.23576223
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23205611
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.22501531
50CTCF_20526341_ChIP-Seq_ESCs_Human1.19774679
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18910739
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18529531
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17843553
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.17727433
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17214247
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15329107
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13840726
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13602714
59MYC_19829295_ChIP-Seq_ESCs_Human1.13499576
60XRN2_22483619_ChIP-Seq_HELA_Human1.12651169
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10948356
62GABP_19822575_ChIP-Seq_HepG2_Human1.10681696
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.10376394
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10233496
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09218519
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.08999224
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.08822924
68CTCF_27219007_Chip-Seq_Bcells_Human1.08334982
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08268466
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.07964783
71SA1_27219007_Chip-Seq_Bcells_Human1.06471630
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05336440
73P53_21459846_ChIP-Seq_SAOS-2_Human1.03933784
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03477562
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02040418
76AR_20517297_ChIP-Seq_VCAP_Human1.01898286
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.01659478
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01542680
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01268382
80NCOR_22424771_ChIP-Seq_293T_Human0.99292141
81HOXB7_26014856_ChIP-Seq_BT474_Human0.98799917
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98777130
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98172024
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95926469
85EWS_26573619_Chip-Seq_HEK293_Human0.95528155
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95439615
87RNF2_27304074_Chip-Seq_NSC_Mouse0.94277195
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93543173
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93395394
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93005379
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.93005379
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92745207
93ERG_20517297_ChIP-Seq_VCAP_Human0.91468362
94E2F1_20622854_ChIP-Seq_HELA_Human0.90272692
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.87495344
96CBP_20019798_ChIP-Seq_JUKART_Human0.86999374
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86999374
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86948546
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85758187
100BCL6_27268052_Chip-Seq_Bcells_Human0.84131786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.58896965
2MP0003787_abnormal_imprinting4.42107627
3MP0009379_abnormal_foot_pigmentation4.32694212
4MP0008877_abnormal_DNA_methylation4.04838581
5MP0003122_maternal_imprinting3.52694276
6MP0001348_abnormal_lacrimal_gland2.82312689
7MP0003123_paternal_imprinting2.62208371
8MP0003121_genomic_imprinting2.54060536
9MP0008875_abnormal_xenobiotic_pharmacok2.45745112
10MP0005377_hearing/vestibular/ear_phenot2.43121057
11MP0003878_abnormal_ear_physiology2.43121057
12MP0006072_abnormal_retinal_apoptosis2.36885349
13MP0002653_abnormal_ependyma_morphology2.22091726
14MP0006276_abnormal_autonomic_nervous2.07816138
15MP0000569_abnormal_digit_pigmentation2.02201017
16MP0002822_catalepsy1.97658345
17MP0001293_anophthalmia1.97118705
18MP0008789_abnormal_olfactory_epithelium1.94706232
19MP0002102_abnormal_ear_morphology1.91340679
20MP0005084_abnormal_gallbladder_morpholo1.89412489
21MP0003646_muscle_fatigue1.83252489
22MP0004142_abnormal_muscle_tone1.79487813
23MP0004885_abnormal_endolymph1.77233069
24MP0000778_abnormal_nervous_system1.68046638
25MP0008872_abnormal_physiological_respon1.63403523
26MP0002837_dystrophic_cardiac_calcinosis1.62555321
27MP0005394_taste/olfaction_phenotype1.55414027
28MP0005499_abnormal_olfactory_system1.55414027
29MP0004742_abnormal_vestibular_system1.54614221
30MP0000049_abnormal_middle_ear1.50553446
31MP0002163_abnormal_gland_morphology1.47457003
32MP0000566_synostosis1.45318698
33MP0002272_abnormal_nervous_system1.36576948
34MP0002557_abnormal_social/conspecific_i1.33851374
35MP0001485_abnormal_pinna_reflex1.25792564
36MP0005551_abnormal_eye_electrophysiolog1.24970333
37MP0004133_heterotaxia1.24671397
38MP0001529_abnormal_vocalization1.24115172
39MP0005423_abnormal_somatic_nervous1.21860333
40MP0003880_abnormal_central_pattern1.21837836
41MP0001968_abnormal_touch/_nociception1.19412740
42MP0009745_abnormal_behavioral_response1.17762120
43MP0002938_white_spotting1.16933495
44MP0000631_abnormal_neuroendocrine_gland1.15922942
45MP0005646_abnormal_pituitary_gland1.14019861
46MP0001986_abnormal_taste_sensitivity1.12971333
47MP0000372_irregular_coat_pigmentation1.12170014
48MP0005195_abnormal_posterior_eye1.12147744
49MP0003186_abnormal_redox_activity1.11314982
50MP0001984_abnormal_olfaction1.10900556
51MP0002733_abnormal_thermal_nociception1.09468537
52MP0002160_abnormal_reproductive_system1.09218985
53MP0003879_abnormal_hair_cell1.08580215
54MP0001873_stomach_inflammation1.07976296
55MP0001905_abnormal_dopamine_level1.07550313
56MP0010030_abnormal_orbit_morphology1.05046720
57MP0005389_reproductive_system_phenotype1.03881917
58MP0000026_abnormal_inner_ear1.02891115
59MP0001486_abnormal_startle_reflex1.02808982
60MP0001970_abnormal_pain_threshold1.01291472
61MP0000427_abnormal_hair_cycle1.00315047
62MP0002736_abnormal_nociception_after0.98528674
63MP0002638_abnormal_pupillary_reflex0.95434703
64MP0004147_increased_porphyrin_level0.94415293
65MP0001963_abnormal_hearing_physiology0.92022855
66MP0005174_abnormal_tail_pigmentation0.91750842
67MP0005408_hypopigmentation0.91647567
68MP0002752_abnormal_somatic_nervous0.90262062
69MP0002063_abnormal_learning/memory/cond0.89002344
70MP0001919_abnormal_reproductive_system0.88955365
71MP0002572_abnormal_emotion/affect_behav0.87850502
72MP0002234_abnormal_pharynx_morphology0.87847832
73MP0009046_muscle_twitch0.84778848
74MP0003195_calcinosis0.84719242
75MP0002095_abnormal_skin_pigmentation0.84546378
76MP0005075_abnormal_melanosome_morpholog0.84539596
77MP0001440_abnormal_grooming_behavior0.84328187
78MP0002735_abnormal_chemical_nociception0.84138525
79MP0000230_abnormal_systemic_arterial0.83822154
80MP0002184_abnormal_innervation0.82525558
81MP0003011_delayed_dark_adaptation0.81185459
82MP0003937_abnormal_limbs/digits/tail_de0.80557015
83MP0005253_abnormal_eye_physiology0.78995115
84MP0003635_abnormal_synaptic_transmissio0.77981363
85MP0002876_abnormal_thyroid_physiology0.77383186
86MP0002064_seizures0.77024376
87MP0003942_abnormal_urinary_system0.76600186
88MP0000955_abnormal_spinal_cord0.74863979
89MP0008775_abnormal_heart_ventricle0.74202443
90MP0002210_abnormal_sex_determination0.73125133
91MP0002067_abnormal_sensory_capabilities0.73085919
92MP0001286_abnormal_eye_development0.71786559
93MP0002882_abnormal_neuron_morphology0.71196496
94MP0005386_behavior/neurological_phenoty0.71125089
95MP0004924_abnormal_behavior0.71125089
96MP0003938_abnormal_ear_development0.69023152
97MP0003136_yellow_coat_color0.67557908
98MP0002734_abnormal_mechanical_nocicepti0.67173351
99MP0001663_abnormal_digestive_system0.66648525
100MP0002229_neurodegeneration0.64454154

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.12622971
2Abnormality of cells of the erythroid lineage (HP:0012130)4.39766604
3Molar tooth sign on MRI (HP:0002419)4.26560951
4Abnormality of midbrain morphology (HP:0002418)4.26560951
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.79744676
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.72981597
7Absent/shortened dynein arms (HP:0200106)3.72981597
8Septo-optic dysplasia (HP:0100842)3.68132762
9Macrocytic anemia (HP:0001972)3.33456648
10Abnormal number of erythroid precursors (HP:0012131)3.28050880
11Pancreatic fibrosis (HP:0100732)3.23342776
12Elevated erythrocyte sedimentation rate (HP:0003565)3.20140354
13Abnormal rod and cone electroretinograms (HP:0008323)3.16717043
14Nephronophthisis (HP:0000090)3.13297906
15Abnormal respiratory epithelium morphology (HP:0012253)3.09872104
16Abnormal respiratory motile cilium morphology (HP:0005938)3.09872104
17Acute necrotizing encephalopathy (HP:0006965)3.07530233
18Aplasia/Hypoplasia of the spleen (HP:0010451)3.00251095
19Colon cancer (HP:0003003)2.98645085
20Mitochondrial inheritance (HP:0001427)2.97727441
21Asplenia (HP:0001746)2.95251718
22Pancreatic cysts (HP:0001737)2.93734288
23Type II lissencephaly (HP:0007260)2.89636856
24Papilledema (HP:0001085)2.87132539
25Pendular nystagmus (HP:0012043)2.80757328
26Congenital stationary night blindness (HP:0007642)2.79931514
27Increased CSF lactate (HP:0002490)2.79186325
28Abnormal mitochondria in muscle tissue (HP:0008316)2.76149953
29True hermaphroditism (HP:0010459)2.70154457
30Acute encephalopathy (HP:0006846)2.68904655
31Stenosis of the external auditory canal (HP:0000402)2.56473127
32Abnormal ciliary motility (HP:0012262)2.54964621
33Medial flaring of the eyebrow (HP:0010747)2.53693704
34Abnormal biliary tract physiology (HP:0012439)2.49881865
35Bile duct proliferation (HP:0001408)2.49881865
36Rib fusion (HP:0000902)2.48008514
37Thyroid-stimulating hormone excess (HP:0002925)2.47546444
38Abnormality of the labia minora (HP:0012880)2.46473028
39Abnormality of the renal medulla (HP:0100957)2.45244094
40Pallor (HP:0000980)2.44753126
41Optic nerve hypoplasia (HP:0000609)2.44676234
42Hepatocellular necrosis (HP:0001404)2.44503889
43Supernumerary spleens (HP:0009799)2.42976844
44Chronic hepatic failure (HP:0100626)2.37455989
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.35531028
46Progressive macrocephaly (HP:0004481)2.34286115
47Absent thumb (HP:0009777)2.32958294
48Stomatitis (HP:0010280)2.25647965
49Sclerocornea (HP:0000647)2.24969885
50Growth hormone deficiency (HP:0000824)2.24302035
51Lissencephaly (HP:0001339)2.21918677
52Hyperglycinemia (HP:0002154)2.17512917
53Optic disc pallor (HP:0000543)2.16930637
54Polydipsia (HP:0001959)2.13704059
55Abnormal drinking behavior (HP:0030082)2.13704059
56Absent septum pellucidum (HP:0001331)2.12570621
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11703721
58Hepatic necrosis (HP:0002605)2.09948974
59Abnormal respiratory motile cilium physiology (HP:0012261)2.09527997
60Maternal diabetes (HP:0009800)2.09447596
61Hypoplasia of the ulna (HP:0003022)2.07189604
62Abolished electroretinogram (ERG) (HP:0000550)2.05781627
63Oligodactyly (hands) (HP:0001180)2.05039306
64Cystic liver disease (HP:0006706)2.04810199
65Oligodactyly (HP:0012165)2.04653276
66Lipid accumulation in hepatocytes (HP:0006561)2.02999211
67Inability to walk (HP:0002540)2.02124753
68Increased serum lactate (HP:0002151)2.01279248
69Polyphagia (HP:0002591)2.01125285
70High anterior hairline (HP:0009890)2.00663228
71Depressed nasal ridge (HP:0000457)2.00165050
72Adrenal hypoplasia (HP:0000835)1.97136928
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.96310865
74Increased corneal curvature (HP:0100692)1.96274184
75Keratoconus (HP:0000563)1.96274184
76Anencephaly (HP:0002323)1.95691507
77Hip dysplasia (HP:0001385)1.92800020
78Abnormality of the 4th metacarpal (HP:0010012)1.89582150
79Postaxial foot polydactyly (HP:0001830)1.88205446
80Increased hepatocellular lipid droplets (HP:0006565)1.86800118
81Ketosis (HP:0001946)1.85084796
82Aplasia/Hypoplasia of the ulna (HP:0006495)1.84680149
83Cerebellar dysplasia (HP:0007033)1.83889918
84Pachygyria (HP:0001302)1.81845753
85Cerebral edema (HP:0002181)1.81629835
86Abnormality of reticulocytes (HP:0004312)1.81576776
87Hypoplasia of the radius (HP:0002984)1.81300169
88Gait imbalance (HP:0002141)1.81159165
89Lactic acidosis (HP:0003128)1.78657559
90Congenital primary aphakia (HP:0007707)1.77861928
91Nephrogenic diabetes insipidus (HP:0009806)1.77730185
92Increased intramyocellular lipid droplets (HP:0012240)1.77622873
93Forearm undergrowth (HP:0009821)1.77033062
94Progressive cerebellar ataxia (HP:0002073)1.75042736
95Horseshoe kidney (HP:0000085)1.72595246
96Delayed CNS myelination (HP:0002188)1.70933501
97Preaxial hand polydactyly (HP:0001177)1.70423620
98Abnormal hemoglobin (HP:0011902)1.69459380
993-Methylglutaconic aciduria (HP:0003535)1.69245311
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68825965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.74349574
2PINK13.55163507
3ZAK3.22453811
4MAP4K23.04270729
5DYRK22.53004272
6WNK42.51993810
7VRK22.50425289
8STK162.44668561
9BCKDK2.28581771
10MAPKAPK32.25200549
11TXK2.07030601
12TLK11.78662871
13WNK31.75314375
14GRK11.71675819
15ADRBK21.69228424
16MAP3K121.62165934
17LRRK21.61645924
18EEF2K1.57648143
19CDK81.56097088
20MAP2K21.50599347
21MAPK131.49952840
22MAPKAPK51.43441049
23BMPR1B1.38718005
24TYRO31.38601363
25STK391.38496477
26PLK41.31383559
27MAP3K111.31339427
28VRK11.31335471
29CDC71.29296514
30TIE11.27533297
31TAOK31.25650196
32NTRK21.21509189
33NUAK11.21289458
34CAMKK21.20157184
35NME11.18248985
36LIMK11.16853969
37PBK1.15960874
38TNK21.13752178
39RPS6KB21.08550582
40NTRK11.07241047
41MATK1.00498684
42CAMK10.99899751
43STK110.98095360
44TGFBR10.94656439
45FRK0.93715702
46OXSR10.92096094
47PRKCG0.90519096
48EPHA40.88108918
49MKNK20.85594260
50TRIM280.84385251
51EIF2AK10.82911894
52DMPK0.82269844
53CDK190.80061445
54DAPK30.77851644
55PLK20.77322371
56PAK60.75373953
57CAMK1G0.74290690
58RPS6KA50.74078700
59PASK0.73750997
60AURKA0.72348648
61CAMK1D0.69842167
62DYRK1B0.69512277
63PNCK0.62714819
64TNIK0.61927821
65BRD40.61857776
66PRKCQ0.60728423
67PIK3CA0.60065990
68AURKB0.58534015
69PAK30.58503276
70GRK50.58453203
71BCR0.56645583
72KIT0.55980756
73PRKCI0.54925217
74PRKACA0.53615750
75PIK3CG0.52786632
76CHEK20.52160330
77KDR0.50646971
78MAP3K40.48645192
79RPS6KA20.48021187
80RPS6KA60.47028299
81PLK30.45718426
82DAPK20.44849158
83PDK20.44175330
84INSRR0.43643141
85ADRBK10.42531859
86MAP2K70.40059911
87PRKCZ0.39932588
88MAPK150.39555776
89LCK0.39046301
90MAP2K40.35887422
91RPS6KA10.35097885
92PTK2B0.34229013
93IKBKB0.33995776
94PLK10.33536536
95NTRK30.32671042
96TESK20.31758145
97SGK2230.31453090
98SGK4940.31453090
99EPHA30.31194482
100ILK0.31159794

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.03499886
2Oxidative phosphorylation_Homo sapiens_hsa001904.15825687
3Parkinsons disease_Homo sapiens_hsa050123.33050587
4Proteasome_Homo sapiens_hsa030502.62427695
5Asthma_Homo sapiens_hsa053102.44350983
6RNA polymerase_Homo sapiens_hsa030202.43176469
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39570650
8Cardiac muscle contraction_Homo sapiens_hsa042602.37107466
9Huntingtons disease_Homo sapiens_hsa050162.32916370
10Protein export_Homo sapiens_hsa030602.29286687
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27691968
12Alzheimers disease_Homo sapiens_hsa050102.23855513
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18020031
14Sulfur relay system_Homo sapiens_hsa041222.14975747
15Linoleic acid metabolism_Homo sapiens_hsa005912.08823854
16Steroid biosynthesis_Homo sapiens_hsa001001.86812607
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78437727
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72851219
19RNA degradation_Homo sapiens_hsa030181.67462261
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63313382
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.57508698
22Caffeine metabolism_Homo sapiens_hsa002321.54241532
23Phototransduction_Homo sapiens_hsa047441.52633434
24Butanoate metabolism_Homo sapiens_hsa006501.47635933
25Fanconi anemia pathway_Homo sapiens_hsa034601.44930722
26Autoimmune thyroid disease_Homo sapiens_hsa053201.34541262
27Allograft rejection_Homo sapiens_hsa053301.34039779
28Homologous recombination_Homo sapiens_hsa034401.25725579
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21683265
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16558105
31Basal transcription factors_Homo sapiens_hsa030221.11582429
32Nicotine addiction_Homo sapiens_hsa050331.11078708
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08229930
34Peroxisome_Homo sapiens_hsa041461.07908779
35Nitrogen metabolism_Homo sapiens_hsa009101.03008610
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98048073
37Tryptophan metabolism_Homo sapiens_hsa003800.97370702
38Hedgehog signaling pathway_Homo sapiens_hsa043400.96022023
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94355868
40Collecting duct acid secretion_Homo sapiens_hsa049660.85859293
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85735090
42Spliceosome_Homo sapiens_hsa030400.85334617
43Propanoate metabolism_Homo sapiens_hsa006400.82236965
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81624504
45Basal cell carcinoma_Homo sapiens_hsa052170.80761132
46Primary immunodeficiency_Homo sapiens_hsa053400.80631917
47DNA replication_Homo sapiens_hsa030300.80043982
48RNA transport_Homo sapiens_hsa030130.79218008
49Ovarian steroidogenesis_Homo sapiens_hsa049130.79001259
50Chemical carcinogenesis_Homo sapiens_hsa052040.78938421
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76753648
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76312877
53Mismatch repair_Homo sapiens_hsa034300.74748832
54Pyrimidine metabolism_Homo sapiens_hsa002400.74008781
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72235945
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72080951
57Morphine addiction_Homo sapiens_hsa050320.68259821
58Base excision repair_Homo sapiens_hsa034100.68038652
59Ether lipid metabolism_Homo sapiens_hsa005650.67552465
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65235747
61Metabolic pathways_Homo sapiens_hsa011000.64610278
62Fat digestion and absorption_Homo sapiens_hsa049750.64050737
63Glutamatergic synapse_Homo sapiens_hsa047240.63767430
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62571496
65Arachidonic acid metabolism_Homo sapiens_hsa005900.62163014
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60714503
67Nucleotide excision repair_Homo sapiens_hsa034200.59195690
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.57456160
69One carbon pool by folate_Homo sapiens_hsa006700.57374472
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57133120
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51707682
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.51477739
73Insulin secretion_Homo sapiens_hsa049110.51138408
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50885275
75Purine metabolism_Homo sapiens_hsa002300.49638090
76Glycerolipid metabolism_Homo sapiens_hsa005610.42568728
77Olfactory transduction_Homo sapiens_hsa047400.42096527
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40874441
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38681367
80Axon guidance_Homo sapiens_hsa043600.37960526
81Serotonergic synapse_Homo sapiens_hsa047260.36606129
82Fatty acid degradation_Homo sapiens_hsa000710.35735071
83Arginine biosynthesis_Homo sapiens_hsa002200.35345573
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.34959227
85Hematopoietic cell lineage_Homo sapiens_hsa046400.34305307
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33900802
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32383236
88Non-homologous end-joining_Homo sapiens_hsa034500.32247340
89GABAergic synapse_Homo sapiens_hsa047270.30322962
90Regulation of autophagy_Homo sapiens_hsa041400.28139012
91Salivary secretion_Homo sapiens_hsa049700.27615213
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27061988
93Arginine and proline metabolism_Homo sapiens_hsa003300.26631608
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.25878448
95Circadian entrainment_Homo sapiens_hsa047130.25553941
96T cell receptor signaling pathway_Homo sapiens_hsa046600.25427844
97Fatty acid elongation_Homo sapiens_hsa000620.24282159
98Rheumatoid arthritis_Homo sapiens_hsa053230.23032315
99Vitamin digestion and absorption_Homo sapiens_hsa049770.21479411
100Notch signaling pathway_Homo sapiens_hsa043300.21354479

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