ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	7.99532809
2	cytidine metabolic process (GO:0046087)	7.99532809
3	cytidine catabolic process (GO:0006216)	7.99532809
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.51509560
5	DNA deamination (GO:0045006)	7.14891103
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.06493029
7	ribosomal small subunit assembly (GO:0000028)	6.38980448
8	maturation of SSU-rRNA (GO:0030490)	5.15728899
9	viral transcription (GO:0019083)	4.88532469
10	translational termination (GO:0006415)	4.63735125
11	sequestering of actin monomers (GO:0042989)	4.59673654
12	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.45309101
13	ribosomal small subunit biogenesis (GO:0042274)	4.35833495
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.34105876
15	ATP synthesis coupled proton transport (GO:0015986)	4.34105876
16	regulation of regulatory T cell differentiation (GO:0045589)	4.32576881
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.16978151
18	actin nucleation (GO:0045010)	4.15323911
19	protein neddylation (GO:0045116)	4.11977011
20	translational elongation (GO:0006414)	4.11450286
21	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.10913419
22	protein targeting to ER (GO:0045047)	4.07950387
23	cotranslational protein targeting to membrane (GO:0006613)	4.04302115
24	positive T cell selection (GO:0043368)	3.98766544
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.94707171
26	regulation of activation of Janus kinase activity (GO:0010533)	3.94463306
27	positive thymic T cell selection (GO:0045059)	3.91934778
28	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.89952446
29	protein localization to endoplasmic reticulum (GO:0070972)	3.88555211
30	behavioral response to nicotine (GO:0035095)	3.81148674
31	positive regulation of T cell apoptotic process (GO:0070234)	3.76246488
32	negative regulation by host of viral transcription (GO:0043922)	3.73550971
33	respiratory electron transport chain (GO:0022904)	3.72224055
34	electron transport chain (GO:0022900)	3.70748023
35	pyrimidine nucleoside catabolic process (GO:0046135)	3.64806056
36	negative T cell selection (GO:0043383)	3.57455739
37	cellular protein complex disassembly (GO:0043624)	3.50765632
38	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.48759389
39	viral life cycle (GO:0019058)	3.47089934
40	positive regulation of interleukin-8 secretion (GO:2000484)	3.44255960
41	positive regulation of calcium-mediated signaling (GO:0050850)	3.44082319
42	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.42508605
43	eosinophil chemotaxis (GO:0048245)	3.38154797
44	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.33350748
45	positive regulation of tolerance induction (GO:0002645)	3.25801985
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.16951022
47	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.14548352
48	negative regulation of T cell apoptotic process (GO:0070233)	3.14339577
49	positive regulation of defense response to virus by host (GO:0002230)	3.14200804
50	iron-sulfur cluster assembly (GO:0016226)	3.13966517
51	metallo-sulfur cluster assembly (GO:0031163)	3.13966517
52	negative regulation of viral genome replication (GO:0045071)	3.11277179
53	thymic T cell selection (GO:0045061)	3.09722613
54	eosinophil migration (GO:0072677)	3.08704070
55	cytolysis (GO:0019835)	3.08654689
56	DNA demethylation (GO:0080111)	3.07268653
57	pyrimidine-containing compound catabolic process (GO:0072529)	3.04700125
58	regulation of T cell tolerance induction (GO:0002664)	3.03430222
59	water-soluble vitamin biosynthetic process (GO:0042364)	3.03358943
60	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.03351652
61	positive regulation of cell killing (GO:0031343)	3.02985104
62	regulation of chronic inflammatory response (GO:0002676)	3.02079985
63	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.99817848
64	regulation of natural killer cell mediated immunity (GO:0002715)	2.99817848
65	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.99748959
66	regulation of isotype switching to IgG isotypes (GO:0048302)	2.99004684
67	regulation of interleukin-8 secretion (GO:2000482)	2.96203078
68	transmission of nerve impulse (GO:0019226)	2.93131429
69	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.93050476
70	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.92992843
71	adaptation of signaling pathway (GO:0023058)	2.91612519
72	cellular response to interleukin-15 (GO:0071350)	2.88589213
73	hydrogen ion transmembrane transport (GO:1902600)	2.83950106
74	T cell receptor signaling pathway (GO:0050852)	2.83469092
75	negative thymic T cell selection (GO:0045060)	2.83065642
76	regulation of cell killing (GO:0031341)	2.81804021
77	protein complex disassembly (GO:0043241)	2.80536808
78	regulation of B cell receptor signaling pathway (GO:0050855)	2.80218136
79	cell proliferation in forebrain (GO:0021846)	2.77551549
80	protein targeting to membrane (GO:0006612)	2.75749428
81	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.75469519
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.75469519
83	negative regulation of mast cell activation (GO:0033004)	2.74260822
84	translational initiation (GO:0006413)	2.74249091
85	protein complex biogenesis (GO:0070271)	2.73463205
86	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.72624781
87	DNA dealkylation (GO:0035510)	2.72208667
88	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.71798384
89	response to pheromone (GO:0019236)	2.71466831
90	macrophage chemotaxis (GO:0048246)	2.69852778
91	proton transport (GO:0015992)	2.68378358
92	platelet dense granule organization (GO:0060155)	2.67358337
93	translation (GO:0006412)	2.67195668
94	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.66486802
95	T cell selection (GO:0045058)	2.64657165
96	T cell costimulation (GO:0031295)	2.64619198
97	macromolecular complex disassembly (GO:0032984)	2.64524108
98	regulation of T cell mediated cytotoxicity (GO:0001914)	2.64400238
99	interferon-gamma production (GO:0032609)	2.62617046
100	hydrogen transport (GO:0006818)	2.62095506

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.27305863
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.25951439
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.34870287
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.15503128
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.03702490
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.65142235
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.61227702
8	VDR_22108803_ChIP-Seq_LS180_Human	2.60421417
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.48745895
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45154661
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04096358
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02016562
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.00087702
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.86207397
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.83256525
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75990428
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.68044703
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.56779904
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.55312320
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54439093
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51076186
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.49054471
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48946011
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.44144181
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43307200
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.43076502
27	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.41486758
28	NANOG_20526341_ChIP-Seq_ESCs_Human	1.38931725
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.36314520
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34896879
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33176804
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32136654
33	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31255365
34	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30954953
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.29684694
36	NCOR_22424771_ChIP-Seq_293T_Human	1.29089691
37	AR_20517297_ChIP-Seq_VCAP_Human	1.28837310
38	RUNX_20019798_ChIP-Seq_JUKART_Human	1.28039803
39	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26775455
40	MYB_26560356_Chip-Seq_TH2_Human	1.26353438
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25344518
42	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.24289717
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23932423
44	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23239710
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22621577
46	BCL6_27268052_Chip-Seq_Bcells_Human	1.21399949
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20973188
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20176269
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18975786
50	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.18682920
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18402808
52	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17393048
53	GATA3_27048872_Chip-Seq_THYMUS_Human	1.16947450
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16073936
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16022541
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.15917305
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15862350
58	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15097576
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14849288
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.14592677
61	GATA3_26560356_Chip-Seq_TH2_Human	1.14200881
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13428235
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.12098901
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11308989
65	ERA_21632823_ChIP-Seq_H3396_Human	1.10185838
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09903358
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09825673
68	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09808479
69	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.07907876
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.07576204
71	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05956578
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.04911317
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04132869
74	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04130761
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04079821
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04079821
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03537754
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03067115
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01987053
80	FOXP3_21729870_ChIP-Seq_TREG_Human	1.01796738
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01304003
82	P53_21459846_ChIP-Seq_SAOS-2_Human	1.01020230
83	ER_23166858_ChIP-Seq_MCF-7_Human	1.00785782
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99903149
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99391805
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98990858
87	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98025887
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97165456
89	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.96422619
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95349780
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94053690
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93373004
93	SA1_27219007_Chip-Seq_Bcells_Human	0.92988117
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92722757
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92693661
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92504940
97	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92504940
98	E2F1_20622854_ChIP-Seq_HELA_Human	0.92413188
99	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.92260468
100	P300_27268052_Chip-Seq_Bcells_Human	0.91300137

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.05008921
2	MP0005671_abnormal_response_to	4.66609391
3	MP0006292_abnormal_olfactory_placode	3.43842604
4	MP0003646_muscle_fatigue	2.27104397
5	MP0005377_hearing/vestibular/ear_phenot	2.23491043
6	MP0003878_abnormal_ear_physiology	2.23491043
7	MP0008789_abnormal_olfactory_epithelium	2.15379810
8	MP0009785_altered_susceptibility_to	2.14888015
9	MP0002163_abnormal_gland_morphology	2.04469145
10	MP0004147_increased_porphyrin_level	1.83412534
11	MP0001485_abnormal_pinna_reflex	1.78000616
12	MP0001919_abnormal_reproductive_system	1.77245162
13	MP0002102_abnormal_ear_morphology	1.76067828
14	MP0001835_abnormal_antigen_presentation	1.70194292
15	MP0004142_abnormal_muscle_tone	1.69046357
16	MP0005551_abnormal_eye_electrophysiolog	1.67135819
17	MP0006072_abnormal_retinal_apoptosis	1.67127603
18	MP0002653_abnormal_ependyma_morphology	1.66506349
19	MP0003763_abnormal_thymus_physiology	1.66092871
20	MP0004885_abnormal_endolymph	1.63963053
21	MP0008877_abnormal_DNA_methylation	1.63583882
22	MP0005645_abnormal_hypothalamus_physiol	1.63170922
23	MP0005499_abnormal_olfactory_system	1.62987909
24	MP0005394_taste/olfaction_phenotype	1.62987909
25	MP0003787_abnormal_imprinting	1.62462427
26	MP0006276_abnormal_autonomic_nervous	1.60479494
27	MP0005389_reproductive_system_phenotype	1.52480173
28	MP0001986_abnormal_taste_sensitivity	1.50532793
29	MP0008872_abnormal_physiological_respon	1.50491176
30	MP0001800_abnormal_humoral_immune	1.50474952
31	MP0003880_abnormal_central_pattern	1.50274191
32	MP0009333_abnormal_splenocyte_physiolog	1.50256956
33	MP0001873_stomach_inflammation	1.42157638
34	MP0001905_abnormal_dopamine_level	1.42100078
35	MP0002876_abnormal_thyroid_physiology	1.40255097
36	MP0002638_abnormal_pupillary_reflex	1.40123871
37	MP0005000_abnormal_immune_tolerance	1.38837072
38	MP0002095_abnormal_skin_pigmentation	1.35608576
39	MP0003866_abnormal_defecation	1.35213881
40	MP0002723_abnormal_immune_serum	1.34127696
41	MP0002277_abnormal_respiratory_mucosa	1.33279161
42	MP0001968_abnormal_touch/_nociception	1.32701025
43	MP0002420_abnormal_adaptive_immunity	1.32384509
44	MP0005025_abnormal_response_to	1.30827874
45	MP0002272_abnormal_nervous_system	1.29394784
46	MP0005646_abnormal_pituitary_gland	1.29112770
47	MP0004742_abnormal_vestibular_system	1.28965411
48	MP0002234_abnormal_pharynx_morphology	1.27585144
49	MP0001819_abnormal_immune_cell	1.26617808
50	MP0004145_abnormal_muscle_electrophysio	1.23348577
51	MP0000372_irregular_coat_pigmentation	1.22945588
52	MP0002148_abnormal_hypersensitivity_rea	1.22916384
53	MP0003879_abnormal_hair_cell	1.21108482
54	MP0003011_delayed_dark_adaptation	1.19929421
55	MP0008875_abnormal_xenobiotic_pharmacok	1.17186780
56	MP0002160_abnormal_reproductive_system	1.16154379
57	MP0002736_abnormal_nociception_after	1.14842498
58	MP0002837_dystrophic_cardiac_calcinosis	1.14233059
59	MP0001970_abnormal_pain_threshold	1.11820632
60	MP0001984_abnormal_olfaction	1.10892091
61	MP0005379_endocrine/exocrine_gland_phen	1.10489758
62	MP0000685_abnormal_immune_system	1.09903436
63	MP0002733_abnormal_thermal_nociception	1.07459900
64	MP0009745_abnormal_behavioral_response	1.06986367
65	MP0000631_abnormal_neuroendocrine_gland	1.06613729
66	MP0005387_immune_system_phenotype	1.06448326
67	MP0001790_abnormal_immune_system	1.06448326
68	MP0006082_CNS_inflammation	1.06219455
69	MP0001188_hyperpigmentation	1.03479162
70	MP0009764_decreased_sensitivity_to	1.03163562
71	MP0005174_abnormal_tail_pigmentation	1.02300787
72	MP0005075_abnormal_melanosome_morpholog	1.00283905
73	MP0002452_abnormal_antigen_presenting	0.99236221
74	MP0000716_abnormal_immune_system	0.94841155
75	MP0000026_abnormal_inner_ear	0.94343506
76	MP0002405_respiratory_system_inflammati	0.94293867
77	MP0005410_abnormal_fertilization	0.93040111
78	MP0005253_abnormal_eye_physiology	0.92107065
79	MP0001293_anophthalmia	0.91668824
80	MP0001853_heart_inflammation	0.90119223
81	MP0003938_abnormal_ear_development	0.88961709
82	MP0002138_abnormal_hepatobiliary_system	0.88459746
83	MP0000049_abnormal_middle_ear	0.87950482
84	MP0005195_abnormal_posterior_eye	0.87299960
85	MP0002933_joint_inflammation	0.86364043
86	MP0001529_abnormal_vocalization	0.85943494
87	MP0001963_abnormal_hearing_physiology	0.85347642
88	MP0003122_maternal_imprinting	0.84056892
89	MP0003136_yellow_coat_color	0.83989930
90	MP0010155_abnormal_intestine_physiology	0.83926205
91	MP0005084_abnormal_gallbladder_morpholo	0.83428013
92	MP0002398_abnormal_bone_marrow	0.83304330
93	MP0003137_abnormal_impulse_conducting	0.80811990
94	MP0001845_abnormal_inflammatory_respons	0.79683356
95	MP0002557_abnormal_social/conspecific_i	0.77781334
96	MP0001440_abnormal_grooming_behavior	0.77538340
97	MP0002752_abnormal_somatic_nervous	0.77019682
98	MP0002184_abnormal_innervation	0.75847019
99	MP0000703_abnormal_thymus_morphology	0.75547120
100	MP0001486_abnormal_startle_reflex	0.74365633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.20905620
2	Aplastic anemia (HP:0001915)	4.08648673
3	Mitochondrial inheritance (HP:0001427)	3.85671279
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.85539318
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.82429139
6	Reticulocytopenia (HP:0001896)	3.81145114
7	IgG deficiency (HP:0004315)	3.76759901
8	Congenital stationary night blindness (HP:0007642)	3.69578208
9	Abnormality of T cell number (HP:0011839)	3.68615295
10	T lymphocytopenia (HP:0005403)	3.64711262
11	3-Methylglutaconic aciduria (HP:0003535)	3.63524944
12	Increased IgM level (HP:0003496)	3.55067522
13	Progressive macrocephaly (HP:0004481)	3.35984767
14	Acute encephalopathy (HP:0006846)	3.35647499
15	Molar tooth sign on MRI (HP:0002419)	3.26327752
16	Abnormality of midbrain morphology (HP:0002418)	3.26327752
17	Hypoproteinemia (HP:0003075)	3.21246927
18	Abnormality of cells of the erythroid lineage (HP:0012130)	3.20938835
19	Pancreatic cysts (HP:0001737)	3.16077075
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.07369425
21	Severe combined immunodeficiency (HP:0004430)	3.05235318
22	Increased CSF lactate (HP:0002490)	3.01840135
23	Elevated erythrocyte sedimentation rate (HP:0003565)	2.99075015
24	Hepatocellular necrosis (HP:0001404)	2.92001494
25	Pancreatic fibrosis (HP:0100732)	2.85492776
26	True hermaphroditism (HP:0010459)	2.82143203
27	Increased hepatocellular lipid droplets (HP:0006565)	2.82020693
28	Increased intramyocellular lipid droplets (HP:0012240)	2.78536787
29	Cerebral edema (HP:0002181)	2.70006825
30	Optic disc pallor (HP:0000543)	2.65432733
31	Abolished electroretinogram (ERG) (HP:0000550)	2.64793262
32	Lipid accumulation in hepatocytes (HP:0006561)	2.60766307
33	Abnormal number of erythroid precursors (HP:0012131)	2.53161837
34	Type II lissencephaly (HP:0007260)	2.49224679
35	Septo-optic dysplasia (HP:0100842)	2.47821784
36	Macrocytic anemia (HP:0001972)	2.46448293
37	Renal Fanconi syndrome (HP:0001994)	2.45709046
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45485400
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45485400
40	Autoimmune hemolytic anemia (HP:0001890)	2.44227143
41	Absent thumb (HP:0009777)	2.41530181
42	Hepatic necrosis (HP:0002605)	2.41014453
43	Medial flaring of the eyebrow (HP:0010747)	2.39299181
44	Abnormality of T cells (HP:0002843)	2.38526153
45	Attenuation of retinal blood vessels (HP:0007843)	2.38232919
46	Colon cancer (HP:0003003)	2.37395418
47	Increased muscle lipid content (HP:0009058)	2.36903448
48	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.35041019
49	Abnormality of B cell number (HP:0010975)	2.33951962
50	Pendular nystagmus (HP:0012043)	2.31380859
51	Decreased central vision (HP:0007663)	2.30652633
52	Thyroiditis (HP:0100646)	2.29351441
53	Abnormality of the prostate (HP:0008775)	2.27228863
54	Pallor (HP:0000980)	2.24405856
55	Combined immunodeficiency (HP:0005387)	2.23727889
56	Abnormal albumin level (HP:0012116)	2.20293264
57	Hypoalbuminemia (HP:0003073)	2.20293264
58	Stenosis of the external auditory canal (HP:0000402)	2.19393961
59	Nephronophthisis (HP:0000090)	2.09898322
60	Abnormality of eosinophils (HP:0001879)	2.08841584
61	Sclerocornea (HP:0000647)	2.02332543
62	Stomatitis (HP:0010280)	2.01622850
63	Exertional dyspnea (HP:0002875)	1.99023764
64	Type 2 muscle fiber atrophy (HP:0003554)	1.98661541
65	Partial duplication of thumb phalanx (HP:0009944)	1.98128495
66	Abnormality of the renal cortex (HP:0011035)	1.97404357
67	Rib fusion (HP:0000902)	1.95694045
68	Agitation (HP:0000713)	1.94515654
69	Pancytopenia (HP:0001876)	1.94445058
70	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92833521
71	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.92336384
72	Cystic liver disease (HP:0006706)	1.92290073
73	Increased serum lactate (HP:0002151)	1.89341847
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.87860758
75	Severe visual impairment (HP:0001141)	1.85758895
76	Abnormality of DNA repair (HP:0003254)	1.85683257
77	Lactic acidosis (HP:0003128)	1.85111236
78	Postaxial foot polydactyly (HP:0001830)	1.82735128
79	Polydipsia (HP:0001959)	1.81767799
80	Abnormal drinking behavior (HP:0030082)	1.81767799
81	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.81748727
82	Asplenia (HP:0001746)	1.81032372
83	Keratoconus (HP:0000563)	1.79678086
84	Increased corneal curvature (HP:0100692)	1.79678086
85	Partial duplication of the phalanx of hand (HP:0009999)	1.78687144
86	Gait imbalance (HP:0002141)	1.78123808
87	Encephalitis (HP:0002383)	1.77939639
88	Forearm undergrowth (HP:0009821)	1.77403609
89	Leukodystrophy (HP:0002415)	1.76900746
90	Tubular atrophy (HP:0000092)	1.76114603
91	Congenital, generalized hypertrichosis (HP:0004540)	1.74325530
92	Hypoplasia of the ulna (HP:0003022)	1.74218189
93	Congenital primary aphakia (HP:0007707)	1.72995200
94	Respiratory failure (HP:0002878)	1.72819974
95	Lethargy (HP:0001254)	1.72290209
96	Chronic diarrhea (HP:0002028)	1.70792939
97	Hypoplasia of the radius (HP:0002984)	1.70335992
98	Gastrointestinal infarctions (HP:0005244)	1.69758822
99	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.67797927
100	Oral leukoplakia (HP:0002745)	1.66751470

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.50617532
2	KDR	4.58234129
3	TESK2	3.60233120
4	BCKDK	2.69263552
5	ADRBK2	2.47623344
6	ZAK	2.47434440
7	CDK19	2.19532920
8	ITK	2.11128230
9	MAP4K1	2.07989980
10	STK16	2.07648123
11	GRK1	1.87904600
12	TLK1	1.87308865
13	MAP3K11	1.87141026
14	TAOK3	1.79217733
15	MAP4K2	1.79138942
16	MUSK	1.78940159
17	WNK4	1.73976515
18	TIE1	1.72163157
19	LIMK1	1.66870755
20	WNK3	1.64249479
21	MAP3K12	1.59677983
22	PIK3CA	1.49649954
23	CAMKK2	1.45348655
24	PINK1	1.43711070
25	PASK	1.40885028
26	NUAK1	1.38144539
27	TYRO3	1.37872704
28	GRK7	1.37776780
29	TEC	1.37564614
30	CAMKK1	1.35126983
31	VRK2	1.33456722
32	PRKCQ	1.28721855
33	FES	1.17503606
34	SYK	1.15491648
35	VRK1	1.12069513
36	LCK	1.08327407
37	FRK	1.06459357
38	CSK	1.05937397
39	GRK6	1.02304542
40	NME1	0.98503980
41	MAPK13	0.97295532
42	BMPR1B	0.96559331
43	TESK1	0.94803640
44	DYRK2	0.90857813
45	MAP2K7	0.86815099
46	BTK	0.85748424
47	INSRR	0.81993104
48	IKBKB	0.80282576
49	EPHB2	0.77893318
50	IKBKE	0.77681845
51	NTRK2	0.73547263
52	LYN	0.71186239
53	LRRK2	0.70505667
54	ADRBK1	0.69846730
55	OBSCN	0.66132741
56	MYLK	0.64026337
57	PIM2	0.62266458
58	PIM1	0.60944674
59	ZAP70	0.59133206
60	PRKACA	0.58501475
61	CAMK1	0.56472619
62	IGF1R	0.56173153
63	PRKCH	0.55480052
64	FYN	0.55385183
65	PLK4	0.53281459
66	MAP3K4	0.52905530
67	PRKCG	0.51612853
68	RPS6KA5	0.49909995
69	TNK2	0.49431191
70	AURKA	0.49202359
71	ROCK1	0.47209740
72	PRKCA	0.47185770
73	OXSR1	0.46394652
74	MAPK15	0.45342630
75	CSF1R	0.40359771
76	DAPK3	0.39295719
77	GRK5	0.37806784
78	EPHA4	0.37713498
79	CAMK2A	0.37534497
80	KIT	0.33913046
81	SIK2	0.33648910
82	PAK3	0.33368479
83	MATK	0.32918443
84	INSR	0.32690001
85	PAK1	0.30638461
86	NTRK1	0.30497197
87	CSNK2A2	0.30444402
88	DYRK1B	0.30351563
89	STK11	0.30233028
90	CSNK1G3	0.29653336
91	MAPKAPK3	0.29563086
92	MAP2K6	0.29349159
93	MARK3	0.28373324
94	NEK2	0.27374383
95	BMPR2	0.26182623
96	CSNK2A1	0.25800244
97	CSNK1A1	0.24222864
98	PRKCB	0.24209859
99	JAK3	0.23932365
100	PRKCD	0.23718379

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.45934066
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.39524270
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.09955266
4	Parkinsons disease_Homo sapiens_hsa05012	3.35920010
5	Proteasome_Homo sapiens_hsa03050	2.89473242
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.54529217
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.49973658
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.44021193
9	Alzheimers disease_Homo sapiens_hsa05010	2.33083513
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.24074586
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.20777305
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18082878
13	Allograft rejection_Homo sapiens_hsa05330	2.16699698
14	RNA polymerase_Homo sapiens_hsa03020	2.16400010
15	Antigen processing and presentation_Homo sapiens_hsa04612	2.11374684
16	Phototransduction_Homo sapiens_hsa04744	2.10132942
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.09972759
18	Huntingtons disease_Homo sapiens_hsa05016	2.07408547
19	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.83089525
20	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.82999763
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79482093
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.73597941
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.65897512
24	Protein export_Homo sapiens_hsa03060	1.62420436
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.56421546
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.42908197
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36598323
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32734707
29	Asthma_Homo sapiens_hsa05310	1.32482997
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.27001496
31	Nicotine addiction_Homo sapiens_hsa05033	1.21433825
32	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.20298236
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13814874
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05036427
35	Olfactory transduction_Homo sapiens_hsa04740	0.99197873
36	Caffeine metabolism_Homo sapiens_hsa00232	0.97650183
37	Peroxisome_Homo sapiens_hsa04146	0.91047339
38	RNA degradation_Homo sapiens_hsa03018	0.89510157
39	Butanoate metabolism_Homo sapiens_hsa00650	0.86163888
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74184940
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73712053
42	Morphine addiction_Homo sapiens_hsa05032	0.73101955
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70426762
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70116447
45	Retinol metabolism_Homo sapiens_hsa00830	0.69847309
46	Viral myocarditis_Homo sapiens_hsa05416	0.69507975
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69480401
48	Malaria_Homo sapiens_hsa05144	0.67384919
49	Measles_Homo sapiens_hsa05162	0.65539351
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.63176959
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63050537
52	Homologous recombination_Homo sapiens_hsa03440	0.62707295
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61786462
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61676416
55	Basal transcription factors_Homo sapiens_hsa03022	0.58124839
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57750838
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57326807
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57091863
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56957963
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.56887929
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.56732555
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55876562
63	Salmonella infection_Homo sapiens_hsa05132	0.53923960
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.53183338
65	Taste transduction_Homo sapiens_hsa04742	0.49885341
66	GABAergic synapse_Homo sapiens_hsa04727	0.47913386
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.47867519
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46747700
69	Purine metabolism_Homo sapiens_hsa00230	0.44675216
70	Regulation of autophagy_Homo sapiens_hsa04140	0.44190743
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43717783
72	Metabolic pathways_Homo sapiens_hsa01100	0.42272649
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42047455
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.39444596
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38175134
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36802069
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36148479
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33852372
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.31474165
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.30864218
81	Shigellosis_Homo sapiens_hsa05131	0.29434042
82	Propanoate metabolism_Homo sapiens_hsa00640	0.29219538
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28048927
84	Serotonergic synapse_Homo sapiens_hsa04726	0.27313164
85	ABC transporters_Homo sapiens_hsa02010	0.26329310
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.25785113
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24816078
88	Salivary secretion_Homo sapiens_hsa04970	0.24027782
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23849612
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23544903
91	Chemokine signaling pathway_Homo sapiens_hsa04062	0.23467320
92	Circadian entrainment_Homo sapiens_hsa04713	0.23215145
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.21655377
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.21486116
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.20794777
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18195330
97	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.16194949
98	Insulin secretion_Homo sapiens_hsa04911	0.15534216
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.15532767
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.14741993

RPS27P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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