RPS27P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.83377065
2viral transcription (GO:0019083)6.20363271
3translational termination (GO:0006415)5.89460301
4negative regulation of telomere maintenance (GO:0032205)5.88163256
5ribosomal small subunit biogenesis (GO:0042274)5.49179144
6maturation of SSU-rRNA (GO:0030490)5.00989461
7translational elongation (GO:0006414)4.90480785
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.86023562
9cotranslational protein targeting to membrane (GO:0006613)4.82208541
10protein targeting to ER (GO:0045047)4.80239931
11regulation of telomere maintenance via telomerase (GO:0032210)4.65802088
12neuron fate determination (GO:0048664)4.62625354
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.59073142
14negative regulation of telomerase activity (GO:0051974)4.54214341
15cell proliferation in forebrain (GO:0021846)4.53283717
16protein localization to endoplasmic reticulum (GO:0070972)4.50767890
17cellular protein complex disassembly (GO:0043624)4.49989063
18axon ensheathment in central nervous system (GO:0032291)4.46311914
19central nervous system myelination (GO:0022010)4.46311914
20viral life cycle (GO:0019058)4.38576587
21nonmotile primary cilium assembly (GO:0035058)4.16214935
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.12100356
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.08635908
24behavioral response to nicotine (GO:0035095)4.00498973
25auditory receptor cell differentiation (GO:0042491)3.95529506
26protein complex disassembly (GO:0043241)3.81485985
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72900461
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.72900461
29NADH dehydrogenase complex assembly (GO:0010257)3.72900461
30positive regulation of respiratory burst (GO:0060267)3.71891566
31nephron tubule morphogenesis (GO:0072078)3.70025092
32nephron epithelium morphogenesis (GO:0072088)3.70025092
33somite development (GO:0061053)3.64087798
34negative regulation of astrocyte differentiation (GO:0048712)3.62981897
35regulation of helicase activity (GO:0051095)3.62035495
36regulation of telomerase activity (GO:0051972)3.58854704
37macromolecular complex disassembly (GO:0032984)3.56804257
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52467861
39ATP synthesis coupled proton transport (GO:0015986)3.52467861
40regulation of telomere maintenance (GO:0032204)3.51962954
41negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.43866069
42protein complex biogenesis (GO:0070271)3.40876361
43translational initiation (GO:0006413)3.39891099
44neuronal stem cell maintenance (GO:0097150)3.39535383
45DNA damage induced protein phosphorylation (GO:0006975)3.38762894
46water-soluble vitamin biosynthetic process (GO:0042364)3.37614255
47radial glial cell differentiation (GO:0060019)3.34273478
48intraciliary transport (GO:0042073)3.32545378
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28371023
50tongue development (GO:0043586)3.24138983
51protein neddylation (GO:0045116)3.22179003
52protein targeting to membrane (GO:0006612)3.17932518
53epithelial cilium movement (GO:0003351)3.17071172
54axoneme assembly (GO:0035082)3.16220220
55negative regulation of mast cell activation (GO:0033004)3.02443811
56substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.01172036
57substrate-independent telencephalic tangential migration (GO:0021826)3.01172036
58fucose catabolic process (GO:0019317)3.00017187
59L-fucose metabolic process (GO:0042354)3.00017187
60L-fucose catabolic process (GO:0042355)3.00017187
61artery development (GO:0060840)2.99210811
62negative regulation of oligodendrocyte differentiation (GO:0048715)2.98520574
63nuclear-transcribed mRNA catabolic process (GO:0000956)2.96151175
64positive regulation of fatty acid transport (GO:2000193)2.94226750
65pyrimidine nucleobase catabolic process (GO:0006208)2.94007588
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92896101
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92896101
68mitochondrial respiratory chain complex assembly (GO:0033108)2.92696064
69platelet dense granule organization (GO:0060155)2.88114953
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87829289
71DNA deamination (GO:0045006)2.87669329
72telencephalon development (GO:0021537)2.84605933
73ribosomal large subunit biogenesis (GO:0042273)2.83860854
74mRNA catabolic process (GO:0006402)2.81045253
75segment specification (GO:0007379)2.79003386
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76743098
77ubiquinone biosynthetic process (GO:0006744)2.72417382
78nucleobase catabolic process (GO:0046113)2.72133455
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71271262
80retina development in camera-type eye (GO:0060041)2.71087543
81negative regulation of glial cell differentiation (GO:0045686)2.70800427
82brain morphogenesis (GO:0048854)2.68409015
83positive regulation of prostaglandin secretion (GO:0032308)2.65750035
84piRNA metabolic process (GO:0034587)2.65293008
85translation (GO:0006412)2.64543993
86negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64154277
87renal tubule morphogenesis (GO:0061333)2.63520593
88transmission of nerve impulse (GO:0019226)2.63403124
89regulation of cilium movement (GO:0003352)2.61237515
90terpenoid biosynthetic process (GO:0016114)2.60975935
91negative regulation of DNA biosynthetic process (GO:2000279)2.60717243
92pattern specification involved in kidney development (GO:0061004)2.57925301
93ubiquinone metabolic process (GO:0006743)2.57757481
94cilium movement (GO:0003341)2.57386281
95sequestering of actin monomers (GO:0042989)2.56704998
96thyroid hormone generation (GO:0006590)2.56272975
97DNA damage response, detection of DNA damage (GO:0042769)2.55451936
98behavioral response to ethanol (GO:0048149)2.55029233
99cardiovascular system development (GO:0072358)2.54608687
100positive regulation of T cell apoptotic process (GO:0070234)2.51541763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63873655
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.13429477
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80296416
4ZNF274_21170338_ChIP-Seq_K562_Hela2.96723081
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72962080
6VDR_22108803_ChIP-Seq_LS180_Human2.32377496
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28719158
8IRF1_19129219_ChIP-ChIP_H3396_Human2.26198674
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.02874997
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00033072
11EZH2_27304074_Chip-Seq_ESCs_Mouse1.98166164
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90726650
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88996928
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87783881
15MYC_18940864_ChIP-ChIP_HL60_Human1.79359915
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76757330
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.70546120
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68298701
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.66029842
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.61314213
21ETV2_25802403_ChIP-Seq_MESCs_Mouse1.56148083
22TP53_22573176_ChIP-Seq_HFKS_Human1.55756485
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.55574833
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54697771
25REST_21632747_ChIP-Seq_MESCs_Mouse1.53881218
26GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51980714
27GATA3_21878914_ChIP-Seq_MCF-7_Human1.48150370
28RNF2_27304074_Chip-Seq_NSC_Mouse1.47315092
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46105066
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45684613
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.42294783
32AR_20517297_ChIP-Seq_VCAP_Human1.41983150
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.41465002
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38004275
35CBP_20019798_ChIP-Seq_JUKART_Human1.38004275
36IGF1R_20145208_ChIP-Seq_DFB_Human1.36657487
37NCOR_22424771_ChIP-Seq_293T_Human1.35418382
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34231103
39ERA_21632823_ChIP-Seq_H3396_Human1.34156976
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31222034
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31105345
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30607331
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29303607
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29030896
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27756258
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27445752
47GBX2_23144817_ChIP-Seq_PC3_Human1.25838817
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24564291
49EWS_26573619_Chip-Seq_HEK293_Human1.24102434
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24007321
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23422054
52NANOG_20526341_ChIP-Seq_ESCs_Human1.22223394
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21178939
54FUS_26573619_Chip-Seq_HEK293_Human1.20935026
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17919613
56TAF2_19829295_ChIP-Seq_ESCs_Human1.16228362
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15891454
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15508851
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14146369
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14146369
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13422491
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.13422491
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09600086
64CTCF_27219007_Chip-Seq_Bcells_Human1.09407227
65BCAT_22108803_ChIP-Seq_LS180_Human1.08496621
66P53_21459846_ChIP-Seq_SAOS-2_Human1.07281260
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06661695
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06647716
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.06195198
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05248334
71P300_19829295_ChIP-Seq_ESCs_Human1.05237891
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04451046
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03903985
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03388492
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03024882
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02150188
77ER_23166858_ChIP-Seq_MCF-7_Human1.01757689
78MYC_19829295_ChIP-Seq_ESCs_Human1.01047122
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.00295154
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.00231814
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99265874
82NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99027613
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98729690
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97754283
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96937883
86TP53_20018659_ChIP-ChIP_R1E_Mouse0.95191298
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95078235
88RUNX2_22187159_ChIP-Seq_PCA_Human0.94405825
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93985169
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91487372
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91421122
92CTCF_20526341_ChIP-Seq_ESCs_Human0.90779761
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.90732061
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90091624
95NANOG_19829295_ChIP-Seq_ESCs_Human0.89862155
96SOX2_19829295_ChIP-Seq_ESCs_Human0.89862155
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89394005
98SA1_27219007_Chip-Seq_Bcells_Human0.88768637
99TCF4_22108803_ChIP-Seq_LS180_Human0.88668233
100HOXB7_26014856_ChIP-Seq_BT474_Human0.88134372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.37636821
2MP0006292_abnormal_olfactory_placode4.23299389
3MP0003136_yellow_coat_color2.87293209
4MP0002653_abnormal_ependyma_morphology2.84786269
5MP0003878_abnormal_ear_physiology2.81704086
6MP0005377_hearing/vestibular/ear_phenot2.81704086
7MP0003787_abnormal_imprinting2.44701097
8MP0004133_heterotaxia2.35634645
9MP0003122_maternal_imprinting2.30380686
10MP0002163_abnormal_gland_morphology2.25308225
11MP0008789_abnormal_olfactory_epithelium2.22319795
12MP0006072_abnormal_retinal_apoptosis2.22274063
13MP0003880_abnormal_central_pattern2.12876898
14MP0003646_muscle_fatigue1.97253896
15MP0004885_abnormal_endolymph1.90727432
16MP0008877_abnormal_DNA_methylation1.87915769
17MP0005360_urolithiasis1.79940965
18MP0006276_abnormal_autonomic_nervous1.79333349
19MP0001485_abnormal_pinna_reflex1.78776676
20MP0005499_abnormal_olfactory_system1.77188688
21MP0005394_taste/olfaction_phenotype1.77188688
22MP0005671_abnormal_response_to1.75204053
23MP0002138_abnormal_hepatobiliary_system1.72713705
24MP0002876_abnormal_thyroid_physiology1.70795512
25MP0004147_increased_porphyrin_level1.68639644
26MP0005084_abnormal_gallbladder_morpholo1.61636572
27MP0001968_abnormal_touch/_nociception1.61455214
28MP0005551_abnormal_eye_electrophysiolog1.60318626
29MP0000631_abnormal_neuroendocrine_gland1.57660853
30MP0004142_abnormal_muscle_tone1.55597606
31MP0003121_genomic_imprinting1.50920060
32MP0000778_abnormal_nervous_system1.49648521
33MP0002102_abnormal_ear_morphology1.48912300
34MP0000566_synostosis1.47873671
35MP0001293_anophthalmia1.46561711
36MP0005645_abnormal_hypothalamus_physiol1.42862166
37MP0008875_abnormal_xenobiotic_pharmacok1.40316158
38MP0002095_abnormal_skin_pigmentation1.39879541
39MP0005174_abnormal_tail_pigmentation1.37534193
40MP0008872_abnormal_physiological_respon1.36973985
41MP0005646_abnormal_pituitary_gland1.35947977
42MP0002638_abnormal_pupillary_reflex1.35845128
43MP0000049_abnormal_middle_ear1.32403341
44MP0002736_abnormal_nociception_after1.30615575
45MP0002272_abnormal_nervous_system1.30332910
46MP0005195_abnormal_posterior_eye1.27600048
47MP0000372_irregular_coat_pigmentation1.25906465
48MP0001986_abnormal_taste_sensitivity1.24316845
49MP0000026_abnormal_inner_ear1.24257475
50MP0009745_abnormal_behavioral_response1.23082862
51MP0002938_white_spotting1.22841461
52MP0003283_abnormal_digestive_organ1.21629558
53MP0003123_paternal_imprinting1.20322556
54MP0001984_abnormal_olfaction1.17586772
55MP0005379_endocrine/exocrine_gland_phen1.16983561
56MP0004742_abnormal_vestibular_system1.16216608
57MP0002557_abnormal_social/conspecific_i1.15941855
58MP0002234_abnormal_pharynx_morphology1.12769261
59MP0001919_abnormal_reproductive_system1.12201431
60MP0008775_abnormal_heart_ventricle1.09595120
61MP0000427_abnormal_hair_cycle1.05891088
62MP0002837_dystrophic_cardiac_calcinosis1.05388104
63MP0001324_abnormal_eye_pigmentation0.99970476
64MP0002752_abnormal_somatic_nervous0.95103732
65MP0001970_abnormal_pain_threshold0.94539925
66MP0008995_early_reproductive_senescence0.94333393
67MP0010030_abnormal_orbit_morphology0.94189212
68MP0005389_reproductive_system_phenotype0.94029058
69MP0003879_abnormal_hair_cell0.92960467
70MP0005075_abnormal_melanosome_morpholog0.92373410
71MP0002733_abnormal_thermal_nociception0.91941853
72MP0002184_abnormal_innervation0.91256560
73MP0001963_abnormal_hearing_physiology0.90019069
74MP0005253_abnormal_eye_physiology0.89974157
75MP0002734_abnormal_mechanical_nocicepti0.89747152
76MP0000230_abnormal_systemic_arterial0.87655121
77MP0003195_calcinosis0.86428947
78MP0002572_abnormal_emotion/affect_behav0.85606904
79MP0001905_abnormal_dopamine_level0.84026592
80MP0003938_abnormal_ear_development0.80378302
81MP0002063_abnormal_learning/memory/cond0.78207061
82MP0001486_abnormal_startle_reflex0.77337396
83MP0001529_abnormal_vocalization0.76579451
84MP0000955_abnormal_spinal_cord0.74788239
85MP0002249_abnormal_larynx_morphology0.73315984
86MP0002233_abnormal_nose_morphology0.73255837
87MP0001663_abnormal_digestive_system0.73232351
88MP0000647_abnormal_sebaceous_gland0.72388032
89MP0002064_seizures0.72009180
90MP0003936_abnormal_reproductive_system0.70836498
91MP0000538_abnormal_urinary_bladder0.70648554
92MP0003635_abnormal_synaptic_transmissio0.69712283
93MP0003866_abnormal_defecation0.67168772
94MP0002277_abnormal_respiratory_mucosa0.67079436
95MP0003937_abnormal_limbs/digits/tail_de0.64499266
96MP0004019_abnormal_vitamin_homeostasis0.63728867
97MP0001286_abnormal_eye_development0.63054424
98MP0002928_abnormal_bile_duct0.62694208
99MP0003638_abnormal_response/metabolism_0.62365117
100MP0001501_abnormal_sleep_pattern0.61075751

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.17081541
2Molar tooth sign on MRI (HP:0002419)4.16170539
3Abnormality of midbrain morphology (HP:0002418)4.16170539
4Pancreatic fibrosis (HP:0100732)3.88889542
5Pancreatic cysts (HP:0001737)3.76409843
6Septo-optic dysplasia (HP:0100842)3.61255126
7Abnormality of cells of the erythroid lineage (HP:0012130)3.56627337
8True hermaphroditism (HP:0010459)3.55718144
9Nephronophthisis (HP:0000090)3.50077646
10Congenital stationary night blindness (HP:0007642)3.30693086
11Aplasia/Hypoplasia of the spleen (HP:0010451)3.28501216
12Asplenia (HP:0001746)3.24045197
13Colon cancer (HP:0003003)3.06756943
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03113904
15Medial flaring of the eyebrow (HP:0010747)2.94436852
16Abnormality of the renal medulla (HP:0100957)2.92389516
17Abnormal rod and cone electroretinograms (HP:0008323)2.84021679
18Absent thumb (HP:0009777)2.81846619
19Abnormal number of erythroid precursors (HP:0012131)2.78925285
20Esophageal atresia (HP:0002032)2.77615220
21Macrocytic anemia (HP:0001972)2.73165902
22Type II lissencephaly (HP:0007260)2.67787008
23Abnormality of the aortic arch (HP:0012303)2.66574823
24Sclerocornea (HP:0000647)2.57903224
25Chronic hepatic failure (HP:0100626)2.57640725
26Abnormal drinking behavior (HP:0030082)2.50047102
27Polydipsia (HP:0001959)2.50047102
28Rib fusion (HP:0000902)2.49904165
29Cystic liver disease (HP:0006706)2.49746112
30Hypoplasia of the ulna (HP:0003022)2.42936318
31Pendular nystagmus (HP:0012043)2.39900656
32Abnormality of the renal cortex (HP:0011035)2.39369558
33Mitochondrial inheritance (HP:0001427)2.37679885
34Postaxial foot polydactyly (HP:0001830)2.37276221
35Gait imbalance (HP:0002141)2.36577740
36Hyperglycinemia (HP:0002154)2.34703891
37Tubular atrophy (HP:0000092)2.32526241
38Congenital primary aphakia (HP:0007707)2.32194533
39Optic nerve hypoplasia (HP:0000609)2.31215868
40Anencephaly (HP:0002323)2.30026438
41Pallor (HP:0000980)2.26616185
42Decreased central vision (HP:0007663)2.26555028
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.26018180
44Absent/shortened dynein arms (HP:0200106)2.26018180
45Short tibia (HP:0005736)2.23239982
46Increased CSF lactate (HP:0002490)2.22176781
47Severe visual impairment (HP:0001141)2.20776306
48Aplasia/Hypoplasia of the ulna (HP:0006495)2.20336689
49Nephrogenic diabetes insipidus (HP:0009806)2.19924230
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.19477863
51Acute necrotizing encephalopathy (HP:0006965)2.17325960
52Abolished electroretinogram (ERG) (HP:0000550)2.16480973
53Hepatocellular necrosis (HP:0001404)2.11561275
54Partial duplication of thumb phalanx (HP:0009944)2.11129858
55Hypoplasia of the radius (HP:0002984)2.10662057
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10379911
57Polyuria (HP:0000103)2.07833197
58Abnormal ciliary motility (HP:0012262)1.99595394
59IgG deficiency (HP:0004315)1.98594499
60Postaxial hand polydactyly (HP:0001162)1.96860561
61Absent septum pellucidum (HP:0001331)1.96770516
62Forearm undergrowth (HP:0009821)1.95587581
63Lipid accumulation in hepatocytes (HP:0006561)1.93992266
64Abnormality of DNA repair (HP:0003254)1.93917682
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92177919
66Congenital hepatic fibrosis (HP:0002612)1.90595145
67Thyroid-stimulating hormone excess (HP:0002925)1.90508490
68Stenosis of the external auditory canal (HP:0000402)1.90144652
69Gastrointestinal atresia (HP:0002589)1.89663975
70Abnormal respiratory motile cilium physiology (HP:0012261)1.89586822
71Abnormality of the labia minora (HP:0012880)1.89044886
72Status epilepticus (HP:0002133)1.87368366
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.84478416
74Fibular hypoplasia (HP:0003038)1.82851944
75Abnormal respiratory epithelium morphology (HP:0012253)1.82715419
76Abnormal respiratory motile cilium morphology (HP:0005938)1.82715419
77Abnormal mitochondria in muscle tissue (HP:0008316)1.82153138
78Supernumerary spleens (HP:0009799)1.81743859
79Duplication of thumb phalanx (HP:0009942)1.80137118
80Depressed nasal ridge (HP:0000457)1.78019945
81Vaginal atresia (HP:0000148)1.77879351
82Acute encephalopathy (HP:0006846)1.77297081
83Hepatic necrosis (HP:0002605)1.76424001
84Abnormality of the proximal phalanges of the hand (HP:0009834)1.76012802
85Aplasia/hypoplasia of the uterus (HP:0008684)1.75948058
86Abnormality of the diencephalon (HP:0010662)1.75914430
87Genital tract atresia (HP:0001827)1.75616465
88Increased hepatocellular lipid droplets (HP:0006565)1.75232679
89Keratoconus (HP:0000563)1.74120668
90Increased corneal curvature (HP:0100692)1.74120668
91Abnormal urine output (HP:0012590)1.73431283
92Male pseudohermaphroditism (HP:0000037)1.73397291
93Abnormality of the middle phalanges of the toes (HP:0010183)1.73301009
94Attenuation of retinal blood vessels (HP:0007843)1.71730872
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71233047
96Synostosis of carpal bones (HP:0005048)1.71225037
97Focal motor seizures (HP:0011153)1.71187897
98Anophthalmia (HP:0000528)1.70462639
99Congenital, generalized hypertrichosis (HP:0004540)1.69279448
10011 pairs of ribs (HP:0000878)1.69144151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK25.07093389
2TLK14.78360897
3MAP4K23.75849647
4WNK43.47735814
5MAP2K63.36270963
6ADRBK22.66907879
7STK392.52743119
8PINK12.50811542
9FRK2.47428131
10ZAK2.34386270
11GRK12.19098819
12TXK2.12305582
13MAP3K112.10819272
14BCKDK2.10115421
15EPHB21.93913783
16EPHA41.87000880
17WNK31.75407090
18CDK191.58207662
19TAOK31.53335212
20NME11.51352522
21MAP3K51.39445675
22DYRK21.38446197
23PASK1.36204329
24NUAK11.34246629
25PIK3CA1.30388469
26CASK1.29594691
27OXSR11.16274506
28VRK21.16217158
29KDR1.14440767
30LIMK11.13535441
31NTRK21.11051014
32TIE11.07263350
33PRKCQ1.02485314
34BMPR1B0.90139938
35SIK20.86526321
36MAP2K20.85947189
37VRK10.85631977
38MAPK130.85556159
39MAP4K10.82007483
40TYRO30.77916957
41MAPKAPK30.77648939
42ITK0.77046997
43ADRBK10.76633128
44MUSK0.74537574
45LRRK20.73375913
46MAPK150.73114461
47PRKCG0.68999551
48STK160.67636478
49CAMK10.67536186
50BTK0.66427278
51INSRR0.65423256
52NEK10.63030048
53PLK40.61765806
54GRK60.58506367
55STK110.58096373
56MAP3K40.57555693
57PRKCZ0.54618878
58AURKA0.52930652
59TEC0.51795455
60PRKACA0.50358427
61TGFBR10.49040785
62TNK20.48910528
63MAPKAPK50.47715516
64NTRK10.46361187
65RPS6KA50.46178971
66PLK20.44257438
67IKBKB0.42679533
68FGFR20.41967081
69PRKCA0.41915250
70CAMKK10.40626363
71MAP3K80.40233287
72CSNK1G20.39407706
73TNIK0.39396907
74CSNK1G30.39255590
75MAPK70.38911740
76RPS6KA60.38594517
77PLK10.38281979
78OBSCN0.37771194
79LCK0.36220485
80PRKCE0.36201955
81CAMKK20.36158619
82ATR0.35898007
83TRIM280.35699063
84PRKD30.35480923
85MAP2K70.35428839
86SYK0.35022313
87AURKB0.34600999
88CSNK1A10.33609137
89HIPK20.32417868
90PRKCH0.30184666
91CSNK2A20.29518648
92ERBB20.29265874
93NEK20.28475688
94CSNK1G10.27175209
95CSNK2A10.26743053
96RIPK10.26290365
97NLK0.25746940
98FES0.24172162
99CAMK2A0.23307635
100ROCK10.21142479

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.27990790
2Oxidative phosphorylation_Homo sapiens_hsa001903.20768276
3Parkinsons disease_Homo sapiens_hsa050122.69229589
4Linoleic acid metabolism_Homo sapiens_hsa005912.54438423
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44682847
6Phototransduction_Homo sapiens_hsa047442.32195641
7Cardiac muscle contraction_Homo sapiens_hsa042602.17813300
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.09274909
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03625577
10Primary immunodeficiency_Homo sapiens_hsa053402.02961175
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87653979
12Huntingtons disease_Homo sapiens_hsa050161.85158062
13Asthma_Homo sapiens_hsa053101.82641908
14Alzheimers disease_Homo sapiens_hsa050101.76334584
15RNA polymerase_Homo sapiens_hsa030201.76307366
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72069152
17Butanoate metabolism_Homo sapiens_hsa006501.69397572
18Caffeine metabolism_Homo sapiens_hsa002321.66863450
19Fat digestion and absorption_Homo sapiens_hsa049751.64815093
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62021741
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54394977
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50822424
23Ether lipid metabolism_Homo sapiens_hsa005651.48062769
24Protein export_Homo sapiens_hsa030601.47303501
25Arachidonic acid metabolism_Homo sapiens_hsa005901.37713702
26Chemical carcinogenesis_Homo sapiens_hsa052041.34242740
27Sulfur relay system_Homo sapiens_hsa041221.33999677
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33128118
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31017423
30Peroxisome_Homo sapiens_hsa041461.27258972
31Fanconi anemia pathway_Homo sapiens_hsa034601.27159826
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.26478661
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25618330
34RNA degradation_Homo sapiens_hsa030181.24023051
35Homologous recombination_Homo sapiens_hsa034401.21468587
36Autoimmune thyroid disease_Homo sapiens_hsa053201.21358005
37Allograft rejection_Homo sapiens_hsa053301.20261468
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18115194
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13758583
40Nitrogen metabolism_Homo sapiens_hsa009101.13543521
41Nicotine addiction_Homo sapiens_hsa050331.10928073
42Olfactory transduction_Homo sapiens_hsa047401.09906196
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08991536
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.05963530
45Pyrimidine metabolism_Homo sapiens_hsa002401.02142794
46Retinol metabolism_Homo sapiens_hsa008301.00965007
47Tryptophan metabolism_Homo sapiens_hsa003801.00079926
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98791617
49Basal transcription factors_Homo sapiens_hsa030220.97444668
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.96247841
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95249002
52Propanoate metabolism_Homo sapiens_hsa006400.92467147
53Vitamin digestion and absorption_Homo sapiens_hsa049770.89017969
54Fatty acid degradation_Homo sapiens_hsa000710.87954015
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87664802
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86781273
57Fatty acid metabolism_Homo sapiens_hsa012120.84206285
58Graft-versus-host disease_Homo sapiens_hsa053320.82858055
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79904607
60Basal cell carcinoma_Homo sapiens_hsa052170.78146397
61Type I diabetes mellitus_Homo sapiens_hsa049400.77268206
62Steroid biosynthesis_Homo sapiens_hsa001000.75667715
63Hedgehog signaling pathway_Homo sapiens_hsa043400.74432474
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71096446
65Hematopoietic cell lineage_Homo sapiens_hsa046400.68157177
66Taste transduction_Homo sapiens_hsa047420.67477060
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66962323
68Metabolic pathways_Homo sapiens_hsa011000.66308904
69Purine metabolism_Homo sapiens_hsa002300.65401931
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.65073801
71One carbon pool by folate_Homo sapiens_hsa006700.64547919
72Fatty acid elongation_Homo sapiens_hsa000620.64110596
73Insulin secretion_Homo sapiens_hsa049110.63238629
74Proteasome_Homo sapiens_hsa030500.62597741
75Glycerolipid metabolism_Homo sapiens_hsa005610.60064177
76Mineral absorption_Homo sapiens_hsa049780.58883623
77Morphine addiction_Homo sapiens_hsa050320.57121810
78Notch signaling pathway_Homo sapiens_hsa043300.55468408
79Ovarian steroidogenesis_Homo sapiens_hsa049130.55292975
80T cell receptor signaling pathway_Homo sapiens_hsa046600.52247122
81Antigen processing and presentation_Homo sapiens_hsa046120.51959415
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49888429
83Glutathione metabolism_Homo sapiens_hsa004800.48380489
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46920916
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45587439
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44358669
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43261484
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.43201422
89Salivary secretion_Homo sapiens_hsa049700.42776135
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39022624
91Fatty acid biosynthesis_Homo sapiens_hsa000610.38779316
92Axon guidance_Homo sapiens_hsa043600.38718703
93Glutamatergic synapse_Homo sapiens_hsa047240.37090589
94PPAR signaling pathway_Homo sapiens_hsa033200.36546840
95Serotonergic synapse_Homo sapiens_hsa047260.34246687
96Sulfur metabolism_Homo sapiens_hsa009200.32552527
97Folate biosynthesis_Homo sapiens_hsa007900.31276442
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31270422
99GABAergic synapse_Homo sapiens_hsa047270.31001961
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30988404

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