RPS28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* translational termination (GO:0006415)9.88367997
2* ribosomal small subunit biogenesis (GO:0042274)9.10121008
3* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.49741907
4* translational elongation (GO:0006414)8.34206701
5* cotranslational protein targeting to membrane (GO:0006613)8.33849246
6* protein targeting to ER (GO:0045047)8.33421784
7* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.95833737
8* protein localization to endoplasmic reticulum (GO:0070972)7.79926660
9maturation of SSU-rRNA (GO:0030490)7.71110606
10* viral life cycle (GO:0019058)7.67374202
11* cellular protein complex disassembly (GO:0043624)7.63549804
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.62797482
13* translational initiation (GO:0006413)7.09431914
14* protein complex disassembly (GO:0043241)6.67097687
15ribosomal large subunit biogenesis (GO:0042273)6.37192555
16* macromolecular complex disassembly (GO:0032984)6.22619815
17establishment of protein localization to mitochondrial membrane (GO:0090151)5.62702984
18* protein targeting to membrane (GO:0006612)5.52806903
19chaperone-mediated protein transport (GO:0072321)5.47077408
20* nuclear-transcribed mRNA catabolic process (GO:0000956)5.41103090
21respiratory electron transport chain (GO:0022904)5.38412985
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.30562866
23electron transport chain (GO:0022900)5.27391552
24* mRNA catabolic process (GO:0006402)5.14433141
25* translation (GO:0006412)5.14121575
26* ribonucleoprotein complex biogenesis (GO:0022613)4.82429342
27* RNA catabolic process (GO:0006401)4.76644859
28DNA deamination (GO:0045006)4.44692895
29protein complex biogenesis (GO:0070271)4.16982794
30mitochondrial respiratory chain complex assembly (GO:0033108)3.99195942
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91557828
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.91557828
33NADH dehydrogenase complex assembly (GO:0010257)3.91557828
34ATP biosynthetic process (GO:0006754)3.90754015
35formation of translation preinitiation complex (GO:0001731)3.84792312
36* rRNA processing (GO:0006364)3.78533316
37* establishment of protein localization to membrane (GO:0090150)3.73220880
38regulation of mitochondrial translation (GO:0070129)3.71299229
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.64624321
40* rRNA metabolic process (GO:0016072)3.64421031
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62850113
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.62006022
43* cellular component biogenesis (GO:0044085)3.61754966
44telomere maintenance via semi-conservative replication (GO:0032201)3.55252503
45protein targeting to mitochondrion (GO:0006626)3.52202165
46DNA strand elongation involved in DNA replication (GO:0006271)3.44521843
47inner mitochondrial membrane organization (GO:0007007)3.43900919
48ncRNA 3-end processing (GO:0043628)3.41527048
49* protein targeting (GO:0006605)3.38433959
50establishment of protein localization to mitochondrion (GO:0072655)3.37203069
51hydrogen ion transmembrane transport (GO:1902600)3.33906825
52* establishment of protein localization to organelle (GO:0072594)3.33588854
53ribonucleoside triphosphate biosynthetic process (GO:0009201)3.32615158
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27116661
55DNA strand elongation (GO:0022616)3.26038993
56protein neddylation (GO:0045116)3.24826317
57oxidative phosphorylation (GO:0006119)3.19830181
58protein localization to mitochondrion (GO:0070585)3.17666356
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08639510
60ATP synthesis coupled proton transport (GO:0015986)3.08639510
61telomere maintenance via recombination (GO:0000722)3.08563202
62spliceosomal complex assembly (GO:0000245)3.06506076
63rRNA modification (GO:0000154)3.06225475
64spliceosomal snRNP assembly (GO:0000387)3.04491627
65cytochrome complex assembly (GO:0017004)2.99862544
66pyrimidine nucleotide catabolic process (GO:0006244)2.99357230
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.96213761
68termination of RNA polymerase III transcription (GO:0006386)2.96213761
69establishment of integrated proviral latency (GO:0075713)2.94738270
70intracellular protein transmembrane import (GO:0044743)2.92384733
71nucleoside triphosphate biosynthetic process (GO:0009142)2.87699643
72purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.86199087
73purine nucleoside monophosphate biosynthetic process (GO:0009127)2.86199087
74pseudouridine synthesis (GO:0001522)2.85968522
75mitochondrial transport (GO:0006839)2.85926659
76mitotic recombination (GO:0006312)2.82365031
77proton transport (GO:0015992)2.81830757
78negative regulation of RNA splicing (GO:0033119)2.80566258
79DNA replication initiation (GO:0006270)2.80114602
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79944032
81* protein localization to membrane (GO:0072657)2.78654116
82proteasome assembly (GO:0043248)2.78410851
83ribosome biogenesis (GO:0042254)2.75067428
84hydrogen transport (GO:0006818)2.75000416
85aerobic respiration (GO:0009060)2.74860504
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73318991
87DNA damage response, detection of DNA damage (GO:0042769)2.71811685
88telomere maintenance via telomere lengthening (GO:0010833)2.70796356
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.70127309
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70046980
91* cellular component disassembly (GO:0022411)2.69266037
92respiratory chain complex IV assembly (GO:0008535)2.65913273
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65472287
94DNA unwinding involved in DNA replication (GO:0006268)2.65065713
95transcription-coupled nucleotide-excision repair (GO:0006283)2.59930926
96viral protein processing (GO:0019082)2.59537578
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.57731054
98* ncRNA processing (GO:0034470)2.57638649
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57299919
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57299919
101deoxyribonucleotide catabolic process (GO:0009264)2.56705956
102* gene expression (GO:0010467)2.56324960
103guanosine-containing compound biosynthetic process (GO:1901070)2.55497904
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54418558
105DNA replication checkpoint (GO:0000076)2.54356382
106kinetochore organization (GO:0051383)2.51753463
107histone mRNA metabolic process (GO:0008334)2.51595620
108base-excision repair, AP site formation (GO:0006285)2.51362876
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50443647
110chromatin remodeling at centromere (GO:0031055)2.48890102
111kinetochore assembly (GO:0051382)2.47622517
112nucleoside monophosphate biosynthetic process (GO:0009124)2.47579950
113protein-cofactor linkage (GO:0018065)2.47164307
114intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45599020
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.45599020
116UTP biosynthetic process (GO:0006228)2.45383137
117ribonucleoside monophosphate biosynthetic process (GO:0009156)2.45119754
118CENP-A containing nucleosome assembly (GO:0034080)2.44981193
119antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.44671478
120* protein localization to organelle (GO:0033365)2.43911332
121establishment of viral latency (GO:0019043)2.42841206
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42490977
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.42490977
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42490977
125negative regulation of ligase activity (GO:0051352)2.42266970
126negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.42266970
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41592267
128signal transduction involved in DNA damage checkpoint (GO:0072422)2.41592267
129regulation of protein heterodimerization activity (GO:0043497)2.41142028
130termination of RNA polymerase II transcription (GO:0006369)2.40788485
131GTP biosynthetic process (GO:0006183)2.40097818
132* ncRNA metabolic process (GO:0034660)2.38760731
133termination of RNA polymerase I transcription (GO:0006363)2.38690436
134ribonucleoprotein complex assembly (GO:0022618)2.37917736
135signal transduction involved in cell cycle checkpoint (GO:0072395)2.37808294
136DNA-templated transcription, termination (GO:0006353)2.35925867
137positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.35132530
138transcription from RNA polymerase I promoter (GO:0006360)2.33725377
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.32665620
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.32097739
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.29883776
142RNA splicing, via transesterification reactions (GO:0000375)2.28658426
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.27644867
144mRNA splicing, via spliceosome (GO:0000398)2.27644867
145* viral transcription (GO:0019083)10.3347473
146ribosomal small subunit assembly (GO:0000028)10.1143004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68702402
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.73390018
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.58052476
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88430975
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.47240806
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.29340598
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.26445721
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.97587303
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96049892
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88754382
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71802934
12* XRN2_22483619_ChIP-Seq_HELA_Human2.70772503
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64456995
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60491768
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60348226
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58486377
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53297283
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49095545
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.45612788
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32517665
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.30645554
22VDR_23849224_ChIP-Seq_CD4+_Human2.27175782
23* TTF2_22483619_ChIP-Seq_HELA_Human2.18318193
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16181260
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14350102
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07934670
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06147528
28DCP1A_22483619_ChIP-Seq_HELA_Human2.03379463
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99909193
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99605129
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98226664
32ELK1_19687146_ChIP-ChIP_HELA_Human1.95638636
33FOXP3_21729870_ChIP-Seq_TREG_Human1.92992233
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76934142
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66719061
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62671785
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59601556
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57167810
39GABP_19822575_ChIP-Seq_HepG2_Human1.56948369
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56659844
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55051341
42VDR_21846776_ChIP-Seq_THP-1_Human1.54321770
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53186847
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51842983
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49977151
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.49571736
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49514635
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.49179636
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44861364
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43968558
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.43672166
52MYC_22102868_ChIP-Seq_BL_Human1.41499387
53* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41225633
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36652043
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.34090005
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33962862
57CIITA_25753668_ChIP-Seq_RAJI_Human1.33569637
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31125527
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31124591
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.29496444
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.27460903
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27380822
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27284641
64SPI1_23547873_ChIP-Seq_NB4_Human1.26601488
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26276276
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.24638282
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24630280
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23096662
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20575160
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17904669
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.16791099
72MYC_18940864_ChIP-ChIP_HL60_Human1.16398744
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15624792
74* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14900568
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.14234974
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14059517
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.13105700
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12516246
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11718114
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11718114
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11718114
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.11693050
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07884116
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07836401
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06366066
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04257818
87KDM5A_27292631_Chip-Seq_BREAST_Human1.02910169
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01983007
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01802965
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99076408
91SA1_27219007_Chip-Seq_ERYTHROID_Human0.98646395
92* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98538554
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98438908
94* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98213624
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97771704
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97603746
97LXR_22292898_ChIP-Seq_THP-1_Human0.97563126
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96606269
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96512665
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95831685
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95553411
102STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95009892
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94863475
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93854794
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.93668868
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93401733
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.92979679
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91871424
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91525700
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91227550
111SCL_19346495_ChIP-Seq_HPC-7_Human0.90660407
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90356778
113MAF_26560356_Chip-Seq_TH2_Human0.90220275
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89298312
115P68_20966046_ChIP-Seq_HELA_Human0.88749782
116BCL6_27268052_Chip-Seq_Bcells_Human0.88262479
117* YY1_22570637_ChIP-Seq_MALME-3M_Human0.88124191
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85488401
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84479973
120SOX2_16153702_ChIP-ChIP_HESCs_Human0.83009906
121SA1_27219007_Chip-Seq_Bcells_Human0.82951677
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82617584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.46891290
2MP0003693_abnormal_embryo_hatching3.92967168
3MP0004957_abnormal_blastocyst_morpholog3.11931500
4MP0003077_abnormal_cell_cycle2.54998452
5MP0010094_abnormal_chromosome_stability2.51143399
6MP0003806_abnormal_nucleotide_metabolis2.39546214
7MP0003111_abnormal_nucleus_morphology2.36467507
8MP0008057_abnormal_DNA_replication2.27144504
9MP0003941_abnormal_skin_development2.05711950
10MP0002396_abnormal_hematopoietic_system1.98126725
11MP0008007_abnormal_cellular_replicative1.97839951
12MP0000490_abnormal_crypts_of1.95885543
13MP0008058_abnormal_DNA_repair1.95771335
14MP0009333_abnormal_splenocyte_physiolog1.87037643
15MP0002163_abnormal_gland_morphology1.86408015
16MP0008932_abnormal_embryonic_tissue1.86152016
17MP0003786_premature_aging1.82543255
18MP0000566_synostosis1.78701221
19MP0006036_abnormal_mitochondrial_physio1.77468692
20MP0005174_abnormal_tail_pigmentation1.75002643
21MP0003763_abnormal_thymus_physiology1.71967328
22MP0001835_abnormal_antigen_presentation1.70190950
23MP0003136_yellow_coat_color1.59729121
24MP0002148_abnormal_hypersensitivity_rea1.53369328
25MP0003938_abnormal_ear_development1.49578517
26MP0004381_abnormal_hair_follicle1.49145939
27MP0003436_decreased_susceptibility_to1.45833184
28MP0010352_gastrointestinal_tract_polyps1.43853894
29MP0002132_abnormal_respiratory_system1.43838087
30MP0003283_abnormal_digestive_organ1.42295673
31MP0004808_abnormal_hematopoietic_stem1.41647215
32MP0000685_abnormal_immune_system1.41610651
33MP0009785_altered_susceptibility_to1.36023667
34MP0003315_abnormal_perineum_morphology1.35161723
35MP0010030_abnormal_orbit_morphology1.34359115
36MP0001800_abnormal_humoral_immune1.34101336
37MP0000350_abnormal_cell_proliferation1.32394422
38MP0002398_abnormal_bone_marrow1.32262924
39MP0000858_altered_metastatic_potential1.28294917
40MP0001853_heart_inflammation1.28288116
41MP0005000_abnormal_immune_tolerance1.26593591
42MP0002722_abnormal_immune_system1.26551359
43MP0002452_abnormal_antigen_presenting1.24611414
44MP0002653_abnormal_ependyma_morphology1.24603612
45MP0005025_abnormal_response_to1.24054326
46MP0000703_abnormal_thymus_morphology1.23886490
47MP0002938_white_spotting1.22336865
48MP0002095_abnormal_skin_pigmentation1.21767681
49MP0001293_anophthalmia1.21487458
50MP0001545_abnormal_hematopoietic_system1.21434956
51MP0005397_hematopoietic_system_phenotyp1.21434956
52MP0008995_early_reproductive_senescence1.20369583
53MP0002405_respiratory_system_inflammati1.20120076
54MP0002420_abnormal_adaptive_immunity1.20019029
55MP0002019_abnormal_tumor_incidence1.18370147
56MP0001819_abnormal_immune_cell1.17801015
57MP0005671_abnormal_response_to1.16814943
58MP0005075_abnormal_melanosome_morpholog1.15564018
59MP0000689_abnormal_spleen_morphology1.15535973
60MP0002166_altered_tumor_susceptibility1.14858075
61MP0010155_abnormal_intestine_physiology1.14846194
62MP0005084_abnormal_gallbladder_morpholo1.13628858
63MP0002723_abnormal_immune_serum1.13353689
64MP0000631_abnormal_neuroendocrine_gland1.13351132
65MP0002638_abnormal_pupillary_reflex1.13251942
66MP0000465_gastrointestinal_hemorrhage1.11847312
67MP0004142_abnormal_muscle_tone1.11365045
68MP0002249_abnormal_larynx_morphology1.11222464
69MP0002429_abnormal_blood_cell1.10268032
70MP0005501_abnormal_skin_physiology1.09827089
71MP0000313_abnormal_cell_death1.09613023
72MP0002796_impaired_skin_barrier1.08999150
73MP0000716_abnormal_immune_system1.08994543
74MP0003567_abnormal_fetal_cardiomyocyte1.08788680
75MP0006054_spinal_hemorrhage1.08554655
76MP0003186_abnormal_redox_activity1.07390473
77MP0001730_embryonic_growth_arrest1.06269501
78MP0002006_tumorigenesis1.06242723
79MP0001764_abnormal_homeostasis1.06120439
80MP0001873_stomach_inflammation1.04052081
81MP0002160_abnormal_reproductive_system1.03836550
82MP0002277_abnormal_respiratory_mucosa1.02126094
83MP0003724_increased_susceptibility_to1.00078782
84MP0003123_paternal_imprinting0.99272309
85MP0001663_abnormal_digestive_system0.97375428
86MP0000372_irregular_coat_pigmentation0.97151175
87MP0001905_abnormal_dopamine_level0.96166476
88MP0005023_abnormal_wound_healing0.95227434
89MP0006035_abnormal_mitochondrial_morpho0.91690082
90MP0006292_abnormal_olfactory_placode0.91518147
91MP0000750_abnormal_muscle_regeneration0.90163325
92MP0005389_reproductive_system_phenotype0.89787127
93MP0009278_abnormal_bone_marrow0.88963140
94MP0001790_abnormal_immune_system0.88813072
95MP0005387_immune_system_phenotype0.88813072
96MP0001346_abnormal_lacrimal_gland0.88547404
97MP0005379_endocrine/exocrine_gland_phen0.87632522
98MP0008789_abnormal_olfactory_epithelium0.87421611
99MP0000049_abnormal_middle_ear0.87376217
100MP0003866_abnormal_defecation0.85918698
101MP0002138_abnormal_hepatobiliary_system0.85702119
102MP0005381_digestive/alimentary_phenotyp0.85345189
103MP0002098_abnormal_vibrissa_morphology0.84934490
104MP0004742_abnormal_vestibular_system0.83875698
105MP0001216_abnormal_epidermal_layer0.83675952
106MP0001485_abnormal_pinna_reflex0.83235905
107MP0001697_abnormal_embryo_size0.82880403
108MP0002080_prenatal_lethality0.82431206
109MP0009053_abnormal_anal_canal0.82240946
110MP0005377_hearing/vestibular/ear_phenot0.82235886
111MP0003878_abnormal_ear_physiology0.82235886
112MP0002060_abnormal_skin_morphology0.81510716
113MP0004019_abnormal_vitamin_homeostasis0.81346559
114MP0000026_abnormal_inner_ear0.80925114
115MP0001919_abnormal_reproductive_system0.80400065
116MP0003718_maternal_effect0.80046775
117MP0006072_abnormal_retinal_apoptosis0.77619449
118MP0003448_altered_tumor_morphology0.77531423
119MP0002419_abnormal_innate_immunity0.76343245
120MP0003453_abnormal_keratinocyte_physiol0.75733309
121MP0002837_dystrophic_cardiac_calcinosis0.75132340
122MP0009250_abnormal_appendicular_skeleto0.74943666
123MP0000678_abnormal_parathyroid_gland0.74115735
124MP0002085_abnormal_embryonic_tissue0.73764068
125MP0001286_abnormal_eye_development0.73619558
126MP0004133_heterotaxia0.73276519
127MP0002697_abnormal_eye_size0.72832006
128MP0000470_abnormal_stomach_morphology0.71886422
129MP0004947_skin_inflammation0.70799987
130MP0000477_abnormal_intestine_morphology0.70614444
131MP0008875_abnormal_xenobiotic_pharmacok0.70397170
132MP0001881_abnormal_mammary_gland0.70256207
133MP0004197_abnormal_fetal_growth/weight/0.70108065
134MP0003011_delayed_dark_adaptation0.69951456
135MP0002234_abnormal_pharynx_morphology0.69431649
136MP0001845_abnormal_inflammatory_respons0.69377589
137MP0002282_abnormal_trachea_morphology0.69263704
138MP0000613_abnormal_salivary_gland0.68843868
139MP0009931_abnormal_skin_appearance0.68488631
140MP0002210_abnormal_sex_determination0.68341863
141MP0005408_hypopigmentation0.68038063
142MP0001672_abnormal_embryogenesis/_devel0.67999207
143MP0001145_abnormal_male_reproductive0.66845958
144MP0002822_catalepsy0.65606795
145MP0003303_peritoneal_inflammation0.63457874

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.42156478
2Reticulocytopenia (HP:0001896)8.79051771
3Abnormal number of erythroid precursors (HP:0012131)8.54343027
4Macrocytic anemia (HP:0001972)6.37276126
5Pallor (HP:0000980)6.01703796
6Aplasia/Hypoplasia of the sacrum (HP:0008517)3.98549521
7Thrombocytosis (HP:0001894)3.66392033
8Cerebral edema (HP:0002181)3.38564388
911 pairs of ribs (HP:0000878)3.35714050
10Abnormal hemoglobin (HP:0011902)3.33392713
11Aplastic anemia (HP:0001915)3.17082390
12Colon cancer (HP:0003003)3.03005625
13Absent thumb (HP:0009777)2.97271835
14Increased hepatocellular lipid droplets (HP:0006565)2.94783463
15Lactic acidosis (HP:0003128)2.84198974
16Abnormality of reticulocytes (HP:0004312)2.83733833
17Depressed nasal ridge (HP:0000457)2.78368181
18Exertional dyspnea (HP:0002875)2.71910889
19Trismus (HP:0000211)2.71602890
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68977663
21Mitochondrial inheritance (HP:0001427)2.68361080
22Abnormality of renal resorption (HP:0011038)2.67486633
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63019505
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63019505
25Multiple enchondromatosis (HP:0005701)2.60554815
26Congenital, generalized hypertrichosis (HP:0004540)2.58072063
27Acute necrotizing encephalopathy (HP:0006965)2.56862228
28Septo-optic dysplasia (HP:0100842)2.45290620
29IgM deficiency (HP:0002850)2.44618205
30Lipid accumulation in hepatocytes (HP:0006561)2.43509950
31Leukodystrophy (HP:0002415)2.42242072
32Stenosis of the external auditory canal (HP:0000402)2.41469682
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39337513
34Hepatocellular necrosis (HP:0001404)2.36207592
35Optic disc pallor (HP:0000543)2.31798026
36Oral leukoplakia (HP:0002745)2.31562687
37Thick lower lip vermilion (HP:0000179)2.27169828
38Asplenia (HP:0001746)2.26876161
39Triphalangeal thumb (HP:0001199)2.26082233
40Migraine (HP:0002076)2.25369738
41Abnormal mitochondria in muscle tissue (HP:0008316)2.22330364
42Hypoplasia of the radius (HP:0002984)2.21091115
43Breast hypoplasia (HP:0003187)2.19641326
44Glycosuria (HP:0003076)2.18614961
45Abnormality of urine glucose concentration (HP:0011016)2.18614961
46Renal Fanconi syndrome (HP:0001994)2.18608589
47Type I transferrin isoform profile (HP:0003642)2.17351586
48Increased CSF lactate (HP:0002490)2.17028016
49Selective tooth agenesis (HP:0001592)2.16194817
50Partial duplication of thumb phalanx (HP:0009944)2.14873739
51Respiratory difficulties (HP:0002880)2.14471541
52Rough bone trabeculation (HP:0100670)2.13907018
533-Methylglutaconic aciduria (HP:0003535)2.12102661
54Carpal bone hypoplasia (HP:0001498)2.11123404
55Partial duplication of the phalanx of hand (HP:0009999)2.09267578
56Elevated erythrocyte sedimentation rate (HP:0003565)2.08888728
57Missing ribs (HP:0000921)2.08592591
58Hyperphosphaturia (HP:0003109)2.08097695
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.06519956
60Woolly hair (HP:0002224)2.06361841
61Cleft eyelid (HP:0000625)2.06144467
62Nasolacrimal duct obstruction (HP:0000579)2.02525732
63Lethargy (HP:0001254)1.98399202
64Increased intramyocellular lipid droplets (HP:0012240)1.97741540
65Maternal diabetes (HP:0009800)1.96940305
66Methylmalonic aciduria (HP:0012120)1.95001684
67Congenital ichthyosiform erythroderma (HP:0007431)1.94178769
68Hepatic necrosis (HP:0002605)1.93733799
69Progressive macrocephaly (HP:0004481)1.93241934
70Myelodysplasia (HP:0002863)1.90353106
71Abnormality of secondary sexual hair (HP:0009888)1.87323663
72Abnormality of the axillary hair (HP:0100134)1.87323663
73Sparse eyelashes (HP:0000653)1.86482185
74Petechiae (HP:0000967)1.85966238
75Glossoptosis (HP:0000162)1.82869350
76Microvesicular hepatic steatosis (HP:0001414)1.82542177
77Patellar aplasia (HP:0006443)1.81818115
78Birth length less than 3rd percentile (HP:0003561)1.80024614
79Rib fusion (HP:0000902)1.79028602
80Premature graying of hair (HP:0002216)1.78539868
81Acute encephalopathy (HP:0006846)1.78327317
82Microretrognathia (HP:0000308)1.78023351
83Abnormality of the parietal bone (HP:0002696)1.75014081
84Aplasia/Hypoplasia of the patella (HP:0006498)1.74952979
85Horseshoe kidney (HP:0000085)1.74552318
86Abnormal number of incisors (HP:0011064)1.71961756
87Generalized aminoaciduria (HP:0002909)1.71897084
88Muscle fiber atrophy (HP:0100295)1.71667776
89Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71555012
90Dicarboxylic aciduria (HP:0003215)1.71555012
91Abnormal urine phosphate concentration (HP:0012599)1.71324643
92Neutropenia (HP:0001875)1.70477843
93Abnormality of the preputium (HP:0100587)1.70325028
94Exercise intolerance (HP:0003546)1.69155848
95Pancytopenia (HP:0001876)1.67953358
96Atresia of the external auditory canal (HP:0000413)1.67890311
97Chromsome breakage (HP:0040012)1.66302790
98Degeneration of anterior horn cells (HP:0002398)1.65720410
99Abnormality of the anterior horn cell (HP:0006802)1.65720410
100Methylmalonic acidemia (HP:0002912)1.65566754
101Decreased subcutaneous fat (HP:0001002)1.65019686
102Hypoplasia of the pons (HP:0012110)1.64959759
103Increased serum lactate (HP:0002151)1.61846112
104Lymphoma (HP:0002665)1.61285592
105Poikiloderma (HP:0001029)1.60967649
106Neoplasm of the pancreas (HP:0002894)1.59715250
107Concave nail (HP:0001598)1.59191031
108Testicular atrophy (HP:0000029)1.58841962
109Bilateral microphthalmos (HP:0007633)1.58759282
110Premature ovarian failure (HP:0008209)1.58510506
111Fragile nails (HP:0001808)1.57986067
112Meckel diverticulum (HP:0002245)1.57745652
113Abnormality of the pons (HP:0007361)1.57543797
114Duplication of thumb phalanx (HP:0009942)1.56068274
115Absent radius (HP:0003974)1.55786325
116Recurrent abscess formation (HP:0002722)1.55782366
117Absent septum pellucidum (HP:0001331)1.55309304
118Tracheoesophageal fistula (HP:0002575)1.54923114
119Megaloblastic anemia (HP:0001889)1.54624344
120Progressive muscle weakness (HP:0003323)1.54290543
121Increased muscle lipid content (HP:0009058)1.53948915
122Emotional lability (HP:0000712)1.53078338
123Abnormal trabecular bone morphology (HP:0100671)1.52627670
124Aplasia/hypoplasia of the uterus (HP:0008684)1.52412563
125Abnormality of the ileum (HP:0001549)1.51477365
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.51414378
127Abnormality of the lacrimal duct (HP:0011481)1.51131685
128Forearm undergrowth (HP:0009821)1.50053037
129Renal tubular dysfunction (HP:0000124)1.49787010
130Homocystinuria (HP:0002156)1.49388877
131Abnormality of homocysteine metabolism (HP:0010919)1.49388877
132Abnormality of methionine metabolism (HP:0010901)1.49371260
133Neoplasm of head and neck (HP:0012288)1.48167731
134Granulocytopenia (HP:0001913)1.47649478
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.47453003
136Parakeratosis (HP:0001036)1.45521013
137Basal cell carcinoma (HP:0002671)1.44333093
138Abnormality of T cell physiology (HP:0011840)1.44315241
139Respiratory failure (HP:0002878)1.43851962
140Aplasia/Hypoplasia of the thymus (HP:0010515)1.43398601
141Pustule (HP:0200039)1.42947448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.25534698
2NME25.21031232
3TLK13.45194286
4BUB12.90987912
5RPS6KB22.79524234
6WEE12.78308350
7PIM22.40941294
8STK162.37496516
9LRRK22.31577941
10SRPK12.16240325
11VRK12.10619078
12EEF2K2.03452429
13TAF11.94748443
14MAP4K11.89463501
15TGFBR11.85878844
16CDC71.76252216
17DYRK31.71718177
18MST41.71016841
19EIF2AK11.68179098
20SMG11.67327074
21ARAF1.66211013
22BCKDK1.55090233
23PASK1.48574763
24CDK71.46175224
25BLK1.38972180
26AURKB1.36020990
27ACVR1B1.35964392
28EIF2AK31.34435240
29MKNK11.33058746
30MAPK151.32150233
31MAPKAPK31.32071673
32MAP3K101.30547635
33TESK21.30056503
34BTK1.24578464
35ILK1.22711504
36NEK21.21571177
37RPS6KA41.18322898
38KDR1.17429385
39PIM11.15542044
40STK101.14907356
41FLT31.13898942
42IRAK41.12803387
43IKBKB1.10848082
44TEC1.06956298
45PLK11.04847901
46PBK1.04252980
47CDK191.00898710
48IRAK31.00382443
49NME10.99830715
50BRSK20.98938237
51EPHA20.98790530
52CDK80.97878084
53PAK40.97849125
54PLK40.95266796
55ATR0.89773287
56MKNK20.89281411
57RPS6KA50.88764792
58BRAF0.88650810
59AURKA0.88002470
60KIT0.87043915
61MAP3K80.84365454
62TYK20.81309119
63MAP3K110.80470775
64MAP2K20.79673854
65CLK10.79217176
66ADRBK20.78827474
67TESK10.78673198
68DAPK30.78228241
69PDK20.78026845
70STK40.77330925
71MAP3K30.77045899
72CSNK2A20.75634016
73CDK40.74942106
74ZAP700.70288645
75NUAK10.70163936
76PKN20.68918267
77EIF2AK20.68898259
78TBK10.68730988
79TAOK20.68317996
80CSNK2A10.66892513
81TTK0.65481147
82ZAK0.64997681
83TSSK60.63329107
84TXK0.63301282
85PAK10.60558770
86ERN10.60346182
87IKBKE0.59668767
88LYN0.59147320
89RPS6KL10.58297350
90RPS6KC10.58297350
91MAP2K30.58048154
92ABL20.57245331
93JAK30.57222685
94STK240.57077267
95MYLK0.56316924
96MAP3K130.56260131
97RPS6KA60.56235608
98CSF1R0.54598387
99NLK0.54485543
100SYK0.53116518
101MAPKAPK50.52972244
102MARK30.52868978
103LCK0.52377012
104PRPF4B0.52041639
105GRK10.51666238
106CCNB10.51252404
107SCYL20.51050753
108LIMK10.50997090
109MATK0.49567217
110CHEK10.49397375
111CHEK20.49241965
112DYRK20.47611127
113PAK20.46862386
114MST1R0.46456962
115PRKCI0.46236129
116SIK10.44426213
117DYRK1B0.44382979
118ADRBK10.43930969
119MAPKAPK20.43186972
120PRKCD0.42662211
121EPHB20.41982218
122GRK60.41669950
123ITK0.41248842
124PLK30.40176059
125PTK60.38093523
126BRSK10.37757300
127CDK30.34739562
128INSRR0.33732352
129MAPK120.33326783
130IRAK20.29604218
131MUSK0.28648345
132RPS6KA10.27360345
133CHUK0.26040719

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.89612645
2DNA replication_Homo sapiens_hsa030303.63911916
3RNA polymerase_Homo sapiens_hsa030203.08455635
4Mismatch repair_Homo sapiens_hsa034303.05847606
5Proteasome_Homo sapiens_hsa030502.99916987
6Spliceosome_Homo sapiens_hsa030402.86733111
7Homologous recombination_Homo sapiens_hsa034402.45896557
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36094918
9Nucleotide excision repair_Homo sapiens_hsa034202.21322920
10Base excision repair_Homo sapiens_hsa034102.19730267
11Pyrimidine metabolism_Homo sapiens_hsa002402.19372227
12Oxidative phosphorylation_Homo sapiens_hsa001902.13328064
13Parkinsons disease_Homo sapiens_hsa050121.99070020
14Protein export_Homo sapiens_hsa030601.98557850
15RNA transport_Homo sapiens_hsa030131.84657271
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73276933
17Huntingtons disease_Homo sapiens_hsa050161.60968268
18One carbon pool by folate_Homo sapiens_hsa006701.58109580
19Fanconi anemia pathway_Homo sapiens_hsa034601.54122619
20Non-homologous end-joining_Homo sapiens_hsa034501.43856822
21RNA degradation_Homo sapiens_hsa030181.41235271
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40313990
23Basal transcription factors_Homo sapiens_hsa030221.40309190
24Cell cycle_Homo sapiens_hsa041101.36476160
25Alzheimers disease_Homo sapiens_hsa050101.28442902
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23965349
27p53 signaling pathway_Homo sapiens_hsa041151.18835712
28Primary immunodeficiency_Homo sapiens_hsa053401.15676324
29Systemic lupus erythematosus_Homo sapiens_hsa053221.13694689
30Purine metabolism_Homo sapiens_hsa002300.98309525
31Antigen processing and presentation_Homo sapiens_hsa046120.96196523
32Epstein-Barr virus infection_Homo sapiens_hsa051690.95992639
33Herpes simplex infection_Homo sapiens_hsa051680.95729750
34Sulfur relay system_Homo sapiens_hsa041220.95422022
35mRNA surveillance pathway_Homo sapiens_hsa030150.86787333
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.82208804
37Hematopoietic cell lineage_Homo sapiens_hsa046400.75884484
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72208998
39Vitamin digestion and absorption_Homo sapiens_hsa049770.71474429
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.71240512
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.69374175
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67823697
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67130911
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66611031
45Folate biosynthesis_Homo sapiens_hsa007900.64925339
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64846436
47Collecting duct acid secretion_Homo sapiens_hsa049660.64384407
48Legionellosis_Homo sapiens_hsa051340.63534386
49Measles_Homo sapiens_hsa051620.63470130
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.63355814
51Viral carcinogenesis_Homo sapiens_hsa052030.62530468
52Glutathione metabolism_Homo sapiens_hsa004800.60416499
53HTLV-I infection_Homo sapiens_hsa051660.59379112
54Allograft rejection_Homo sapiens_hsa053300.59366373
55Arachidonic acid metabolism_Homo sapiens_hsa005900.59341158
56Asthma_Homo sapiens_hsa053100.59032570
57Graft-versus-host disease_Homo sapiens_hsa053320.57346355
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55910944
59Leishmaniasis_Homo sapiens_hsa051400.55596358
60Sulfur metabolism_Homo sapiens_hsa009200.55124024
61Apoptosis_Homo sapiens_hsa042100.52567795
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51187522
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50059443
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49342100
65Type I diabetes mellitus_Homo sapiens_hsa049400.48366675
66Cardiac muscle contraction_Homo sapiens_hsa042600.47688287
67Small cell lung cancer_Homo sapiens_hsa052220.47196237
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46932795
69Thyroid cancer_Homo sapiens_hsa052160.46814493
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46496556
71N-Glycan biosynthesis_Homo sapiens_hsa005100.46234798
72Other glycan degradation_Homo sapiens_hsa005110.46129888
73Pentose phosphate pathway_Homo sapiens_hsa000300.45085215
74Malaria_Homo sapiens_hsa051440.43801523
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.43373469
76Basal cell carcinoma_Homo sapiens_hsa052170.42880521
77Notch signaling pathway_Homo sapiens_hsa043300.42059801
78Acute myeloid leukemia_Homo sapiens_hsa052210.41975322
79Pyruvate metabolism_Homo sapiens_hsa006200.41584110
80Rheumatoid arthritis_Homo sapiens_hsa053230.41553769
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41300871
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.41020694
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40159439
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38864454
85Shigellosis_Homo sapiens_hsa051310.37107303
86Bladder cancer_Homo sapiens_hsa052190.37084823
87Hepatitis B_Homo sapiens_hsa051610.35873279
88Chemical carcinogenesis_Homo sapiens_hsa052040.34742313
89Influenza A_Homo sapiens_hsa051640.34173405
90B cell receptor signaling pathway_Homo sapiens_hsa046620.33017399
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.31910931
92Tyrosine metabolism_Homo sapiens_hsa003500.31769617
93Alcoholism_Homo sapiens_hsa050340.31729285
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30798833
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.30408256
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30112699
97Autoimmune thyroid disease_Homo sapiens_hsa053200.29565279
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29330354
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29259019
100MicroRNAs in cancer_Homo sapiens_hsa052060.29217068
101Pertussis_Homo sapiens_hsa051330.27690207
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27415611
103Pathways in cancer_Homo sapiens_hsa052000.27082457
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25005342
105Metabolic pathways_Homo sapiens_hsa011000.24694944
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24246726
107HIF-1 signaling pathway_Homo sapiens_hsa040660.23571276
108Hedgehog signaling pathway_Homo sapiens_hsa043400.23482517
109TGF-beta signaling pathway_Homo sapiens_hsa043500.23308528
110Toxoplasmosis_Homo sapiens_hsa051450.22294230
111Linoleic acid metabolism_Homo sapiens_hsa005910.22179197
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21753109
113Galactose metabolism_Homo sapiens_hsa000520.21683365
114Fructose and mannose metabolism_Homo sapiens_hsa000510.21526861
115Viral myocarditis_Homo sapiens_hsa054160.21040536
116Selenocompound metabolism_Homo sapiens_hsa004500.20843806
117Biosynthesis of amino acids_Homo sapiens_hsa012300.20821792
118T cell receptor signaling pathway_Homo sapiens_hsa046600.20638572
119Osteoclast differentiation_Homo sapiens_hsa043800.19987569
120Chronic myeloid leukemia_Homo sapiens_hsa052200.19941883
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19829752
122Fat digestion and absorption_Homo sapiens_hsa049750.19323608
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18464050
124Fatty acid elongation_Homo sapiens_hsa000620.18132692
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17445066
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15787957
127Carbon metabolism_Homo sapiens_hsa012000.15684270
128Peroxisome_Homo sapiens_hsa041460.14558147
129Retinol metabolism_Homo sapiens_hsa008300.12336121
130Caffeine metabolism_Homo sapiens_hsa002320.07696158
131Arginine and proline metabolism_Homo sapiens_hsa003300.06667910
132Regulation of autophagy_Homo sapiens_hsa041400.06294454
133Phototransduction_Homo sapiens_hsa047440.06228124
134Mineral absorption_Homo sapiens_hsa049780.05346339
135Tryptophan metabolism_Homo sapiens_hsa003800.05178344
136Staphylococcus aureus infection_Homo sapiens_hsa051500.02972730

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