ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.85764287
2	viral transcription (GO:0019083)	8.71485176
3	ribosomal small subunit assembly (GO:0000028)	8.61318595
4	translational termination (GO:0006415)	8.18609151
5	translational elongation (GO:0006414)	7.27382994
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.18811633
7	protein targeting to ER (GO:0045047)	7.00936780
8	cotranslational protein targeting to membrane (GO:0006613)	7.00527365
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.68871178
10	protein localization to endoplasmic reticulum (GO:0070972)	6.63173312
11	viral life cycle (GO:0019058)	6.39313927
12	cellular protein complex disassembly (GO:0043624)	6.21388655
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.16517560
14	maturation of SSU-rRNA (GO:0030490)	6.13317125
15	translational initiation (GO:0006413)	5.67961335
16	ATP synthesis coupled proton transport (GO:0015986)	5.57348878
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.57348878
18	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.56338775
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.52407961
20	chaperone-mediated protein transport (GO:0072321)	5.36538925
21	protein complex disassembly (GO:0043241)	5.27335939
22	macromolecular complex disassembly (GO:0032984)	4.90927606
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.88700890
24	ncRNA 3-end processing (GO:0043628)	4.86368773
25	translation (GO:0006412)	4.85602566
26	protein targeting to membrane (GO:0006612)	4.70659567
27	respiratory electron transport chain (GO:0022904)	4.65740883
28	ribonucleoprotein complex biogenesis (GO:0022613)	4.64627090
29	ribosomal large subunit biogenesis (GO:0042273)	4.60409769
30	electron transport chain (GO:0022900)	4.56215764
31	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.46434176
32	DNA deamination (GO:0045006)	4.43883118
33	cellular component biogenesis (GO:0044085)	4.23671832
34	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.23537569
35	protein complex biogenesis (GO:0070271)	4.18726502
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.16234823
37	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.16234823
38	NADH dehydrogenase complex assembly (GO:0010257)	4.16234823
39	protein targeting to mitochondrion (GO:0006626)	4.02883629
40	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.00513815
41	mRNA catabolic process (GO:0006402)	4.00385142
42	pseudouridine synthesis (GO:0001522)	3.98298252
43	mitochondrial respiratory chain complex assembly (GO:0033108)	3.92124682
44	pyrimidine nucleotide catabolic process (GO:0006244)	3.81553204
45	base-excision repair, AP site formation (GO:0006285)	3.72737354
46	establishment of protein localization to mitochondrion (GO:0072655)	3.69370787
47	deoxyribonucleotide catabolic process (GO:0009264)	3.69195297
48	RNA catabolic process (GO:0006401)	3.66019269
49	iron-sulfur cluster assembly (GO:0016226)	3.59464111
50	metallo-sulfur cluster assembly (GO:0031163)	3.59464111
51	respiratory chain complex IV assembly (GO:0008535)	3.57910768
52	rRNA processing (GO:0006364)	3.55746411
53	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.54629661
54	GTP biosynthetic process (GO:0006183)	3.51167447
55	deoxyribose phosphate catabolic process (GO:0046386)	3.50649075
56	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.50461437
57	ATP biosynthetic process (GO:0006754)	3.50238487
58	peptidyl-histidine modification (GO:0018202)	3.45922622
59	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.44660034
60	cytochrome complex assembly (GO:0017004)	3.43760990
61	purine deoxyribonucleotide catabolic process (GO:0009155)	3.40540408
62	rRNA metabolic process (GO:0016072)	3.39714915
63	protein localization to mitochondrion (GO:0070585)	3.38616555
64	protein neddylation (GO:0045116)	3.37184467
65	UTP biosynthetic process (GO:0006228)	3.33103083
66	guanosine-containing compound biosynthetic process (GO:1901070)	3.31496586
67	protein targeting (GO:0006605)	3.28462060
68	establishment of protein localization to membrane (GO:0090150)	3.23263317
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.22597856
70	gonadal mesoderm development (GO:0007506)	3.19614370
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18149348
72	termination of RNA polymerase III transcription (GO:0006386)	3.18149348
73	regulation of mitochondrial translation (GO:0070129)	3.12687063
74	purine nucleotide salvage (GO:0032261)	3.05978693
75	2-deoxyribonucleotide metabolic process (GO:0009394)	3.05688912
76	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.03637028
77	GMP metabolic process (GO:0046037)	3.02705781
78	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.02599615
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.02599615
80	UTP metabolic process (GO:0046051)	3.01709185
81	oxidative phosphorylation (GO:0006119)	3.01157276
82	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.98765125
83	establishment of protein localization to organelle (GO:0072594)	2.98130279
84	mitochondrial transport (GO:0006839)	2.96794778
85	hydrogen ion transmembrane transport (GO:1902600)	2.93357334
86	ribosome biogenesis (GO:0042254)	2.90312758
87	negative regulation of B cell apoptotic process (GO:0002903)	2.88875817
88	deoxyribose phosphate metabolic process (GO:0019692)	2.86805606
89	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.86192243
90	deoxyribose phosphate biosynthetic process (GO:0046385)	2.86192243
91	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.83589082
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.81104030
93	proteasome assembly (GO:0043248)	2.79447821
94	CTP biosynthetic process (GO:0006241)	2.72946278
95	CTP metabolic process (GO:0046036)	2.72946278
96	formation of translation preinitiation complex (GO:0001731)	2.68713689
97	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.67407446
98	purine deoxyribonucleotide metabolic process (GO:0009151)	2.65924553
99	rRNA modification (GO:0000154)	2.65738018
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.64245414

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.19786764
2	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.50936674
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.35047165
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.23695782
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.21294152
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17298349
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.14836916
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.90313787
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.84474648
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.77084430
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.76666342
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.75389083
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63965514
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.38688763
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.37011242
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.36603014
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.31581781
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.19087462
19	VDR_21846776_ChIP-Seq_THP-1_Human	2.14912495
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.14719283
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12149045
22	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.11809209
23	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.09505348
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08145681
25	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.07515513
26	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05857200
27	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.04921475
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.01846179
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.00876328
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.95125452
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.94425185
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92831809
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.92126283
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.82434584
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.74416771
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.72756840
37	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.71270405
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.58433287
39	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.55895923
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.53328108
41	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.53002370
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.52657451
43	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.51618041
44	BCL6_27268052_Chip-Seq_Bcells_Human	1.51006053
45	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.49425885
46	MAF_26560356_Chip-Seq_TH2_Human	1.43432159
47	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.40942336
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.40077679
49	MYC_22102868_ChIP-Seq_BL_Human	1.38205782
50	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.37943562
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.36820481
52	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.36257193
53	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.35576966
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.31349487
55	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.30846668
56	P68_20966046_ChIP-Seq_HELA_Human	1.29756908
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28327069
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.26117847
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.26092402
60	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.25298683
61	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.22237849
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21259158
63	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.21005244
64	SPI1_23547873_ChIP-Seq_NB4_Human	1.20727567
65	BCOR_27268052_Chip-Seq_Bcells_Human	1.20712718
66	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.20365957
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.20136318
68	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19266440
69	UTX_26944678_Chip-Seq_JUKART_Human	1.18477044
70	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.17840539
71	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.17281633
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17163111
73	ZNF263_19887448_ChIP-Seq_K562_Human	1.16161139
74	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.15631534
75	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.15115628
76	LXR_22292898_ChIP-Seq_THP-1_Human	1.14311968
77	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11616006
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11456763
79	E2F1_20622854_ChIP-Seq_HELA_Human	1.11251647
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10190935
81	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.09673538
82	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.09219853
83	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.08512855
84	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.07459229
85	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07174840
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.07128908
87	SA1_27219007_Chip-Seq_Bcells_Human	1.04638029
88	VDR_24763502_ChIP-Seq_THP-1_Human	1.03161429
89	CTCF_21964334_Chip-Seq_Bcells_Human	1.02917853
90	MAF_26560356_Chip-Seq_TH1_Human	1.01375417
91	PHF8_20622854_ChIP-Seq_HELA_Human	1.00577197
92	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00562182
93	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.00508638
94	STAT1_20625510_ChIP-Seq_HELA_Human	1.00091478
95	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.99583674
96	P300_27268052_Chip-Seq_Bcells_Human	0.99580632
97	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.98596266
98	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98515837
99	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98037724
100	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.97933287

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.81801231
2	MP0002163_abnormal_gland_morphology	4.12942367
3	MP0009333_abnormal_splenocyte_physiolog	3.18083899
4	MP0005671_abnormal_response_to	2.91998313
5	MP0000372_irregular_coat_pigmentation	2.64766740
6	MP0003763_abnormal_thymus_physiology	2.56138566
7	MP0006036_abnormal_mitochondrial_physio	2.54444250
8	MP0002132_abnormal_respiratory_system	2.48373894
9	MP0005379_endocrine/exocrine_gland_phen	2.41320608
10	MP0003186_abnormal_redox_activity	2.31889543
11	MP0000678_abnormal_parathyroid_gland	2.22732391
12	MP0006292_abnormal_olfactory_placode	2.16628307
13	MP0003646_muscle_fatigue	2.16611755
14	MP0003786_premature_aging	2.16512710
15	MP0005075_abnormal_melanosome_morpholog	1.99829375
16	MP0008995_early_reproductive_senescence	1.97891317
17	MP0001835_abnormal_antigen_presentation	1.92193148
18	MP0003806_abnormal_nucleotide_metabolis	1.87095154
19	MP0001800_abnormal_humoral_immune	1.84194974
20	MP0009785_altered_susceptibility_to	1.76379191
21	MP0002420_abnormal_adaptive_immunity	1.73350823
22	MP0000681_abnormal_thyroid_gland	1.70189935
23	MP0001873_stomach_inflammation	1.69907098
24	MP0005025_abnormal_response_to	1.69172843
25	MP0001819_abnormal_immune_cell	1.68352609
26	MP0005387_immune_system_phenotype	1.67567054
27	MP0001790_abnormal_immune_system	1.67567054
28	MP0005000_abnormal_immune_tolerance	1.67298030
29	MP0002723_abnormal_immune_serum	1.64689273
30	MP0005646_abnormal_pituitary_gland	1.64670584
31	MP0002148_abnormal_hypersensitivity_rea	1.62591045
32	MP0000703_abnormal_thymus_morphology	1.59917594
33	MP0000685_abnormal_immune_system	1.59851157
34	MP0002160_abnormal_reproductive_system	1.58520252
35	MP0002398_abnormal_bone_marrow	1.57417707
36	MP0003436_decreased_susceptibility_to	1.52209516
37	MP0001764_abnormal_homeostasis	1.48128842
38	MP0005389_reproductive_system_phenotype	1.45822572
39	MP0000716_abnormal_immune_system	1.44573771
40	MP0002452_abnormal_antigen_presenting	1.43264040
41	MP0003693_abnormal_embryo_hatching	1.40836825
42	MP0002722_abnormal_immune_system	1.39827355
43	MP0008058_abnormal_DNA_repair	1.38309093
44	MP0001986_abnormal_taste_sensitivity	1.38299250
45	MP0006082_CNS_inflammation	1.38218482
46	MP0004145_abnormal_muscle_electrophysio	1.38174527
47	MP0000689_abnormal_spleen_morphology	1.35903132
48	MP0004858_abnormal_nervous_system	1.35212026
49	MP0005083_abnormal_biliary_tract	1.30597056
50	MP0005670_abnormal_white_adipose	1.30175135
51	MP0002429_abnormal_blood_cell	1.29139590
52	MP0001919_abnormal_reproductive_system	1.28682955
53	MP0002277_abnormal_respiratory_mucosa	1.27731183
54	MP0002876_abnormal_thyroid_physiology	1.26643187
55	MP0002837_dystrophic_cardiac_calcinosis	1.23419952
56	MP0002405_respiratory_system_inflammati	1.20507928
57	MP0002419_abnormal_innate_immunity	1.18337272
58	MP0008789_abnormal_olfactory_epithelium	1.17463694
59	MP0002095_abnormal_skin_pigmentation	1.14748031
60	MP0003011_delayed_dark_adaptation	1.08254586
61	MP0003866_abnormal_defecation	1.06955545
62	MP0001661_extended_life_span	1.04759425
63	MP0004381_abnormal_hair_follicle	1.04097110
64	MP0001905_abnormal_dopamine_level	0.99844099
65	MP0006035_abnormal_mitochondrial_morpho	0.99691124
66	MP0002933_joint_inflammation	0.98975885
67	MP0001845_abnormal_inflammatory_respons	0.98528610
68	MP0004147_increased_porphyrin_level	0.96317629
69	MP0005464_abnormal_platelet_physiology	0.89997941
70	MP0008469_abnormal_protein_level	0.89474951
71	MP0003123_paternal_imprinting	0.89375332
72	MP0000049_abnormal_middle_ear	0.88638965
73	MP0005174_abnormal_tail_pigmentation	0.85256184
74	MP0005636_abnormal_mineral_homeostasis	0.83353210
75	MP0001853_heart_inflammation	0.82615036
76	MP0002019_abnormal_tumor_incidence	0.82329526
77	MP0002249_abnormal_larynx_morphology	0.80294204
78	MP0001270_distended_abdomen	0.78469514
79	MP0000015_abnormal_ear_pigmentation	0.76251769
80	MP0009278_abnormal_bone_marrow	0.75625785
81	MP0001663_abnormal_digestive_system	0.74951473
82	MP0010155_abnormal_intestine_physiology	0.74396830
83	MP0000313_abnormal_cell_death	0.73281368
84	MP0002210_abnormal_sex_determination	0.72761574
85	MP0002693_abnormal_pancreas_physiology	0.72458285
86	MP0005645_abnormal_hypothalamus_physiol	0.72269014
87	MP0001727_abnormal_embryo_implantation	0.72060456
88	MP0001881_abnormal_mammary_gland	0.71597365
89	MP0009765_abnormal_xenobiotic_induced	0.69533921
90	MP0008875_abnormal_xenobiotic_pharmacok	0.67671686
91	MP0005410_abnormal_fertilization	0.66278249
92	MP0005220_abnormal_exocrine_pancreas	0.65860701
93	MP0000750_abnormal_muscle_regeneration	0.65374906
94	MP0000343_altered_response_to	0.65321660
95	MP0009643_abnormal_urine_homeostasis	0.64898538
96	MP0005451_abnormal_body_composition	0.63043910
97	MP0005058_abnormal_lysosome_morphology	0.62102321
98	MP0008873_increased_physiological_sensi	0.60895321
99	MP0000490_abnormal_crypts_of	0.60853136
100	MP0004142_abnormal_muscle_tone	0.60693098

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.29831373
2	Abnormal number of erythroid precursors (HP:0012131)	5.17394296
3	Abnormality of cells of the erythroid lineage (HP:0012130)	5.16436515
4	Abnormal mitochondria in muscle tissue (HP:0008316)	5.09423389
5	Mitochondrial inheritance (HP:0001427)	4.99954957
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.93829904
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.93829904
8	Acute encephalopathy (HP:0006846)	4.59867458
9	3-Methylglutaconic aciduria (HP:0003535)	4.49571314
10	Increased intramyocellular lipid droplets (HP:0012240)	4.39605068
11	Increased CSF lactate (HP:0002490)	4.37790923
12	Progressive macrocephaly (HP:0004481)	4.33451024
13	Hepatocellular necrosis (HP:0001404)	4.27166337
14	Increased muscle lipid content (HP:0009058)	3.97163747
15	Reticulocytopenia (HP:0001896)	3.96165695
16	Hepatic necrosis (HP:0002605)	3.93011162
17	Increased hepatocellular lipid droplets (HP:0006565)	3.85321283
18	Renal Fanconi syndrome (HP:0001994)	3.81469636
19	Macrocytic anemia (HP:0001972)	3.70804628
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.69043801
21	Aplastic anemia (HP:0001915)	3.57932891
22	Pallor (HP:0000980)	3.55508818
23	Lipid accumulation in hepatocytes (HP:0006561)	3.53583598
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.31030347
25	Cerebral edema (HP:0002181)	3.25588767
26	Lactic acidosis (HP:0003128)	3.21370329
27	Increased serum lactate (HP:0002151)	3.12215450
28	Exercise intolerance (HP:0003546)	3.09148849
29	Exertional dyspnea (HP:0002875)	3.01245900
30	Respiratory failure (HP:0002878)	2.93198486
31	Respiratory difficulties (HP:0002880)	2.90515316
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90354063
33	Microretrognathia (HP:0000308)	2.62798856
34	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.56541223
35	Testicular atrophy (HP:0000029)	2.54024593
36	Optic disc pallor (HP:0000543)	2.51371801
37	Abnormal hemoglobin (HP:0011902)	2.42121937
38	Obstructive lung disease (HP:0006536)	2.34157775
39	Chronic obstructive pulmonary disease (HP:0006510)	2.34157775
40	Elevated erythrocyte sedimentation rate (HP:0003565)	2.32059001
41	Agammaglobulinemia (HP:0004432)	2.30843517
42	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.30466281
43	Constricted visual fields (HP:0001133)	2.28267899
44	Thrombocytosis (HP:0001894)	2.27574911
45	Cleft eyelid (HP:0000625)	2.26881204
46	Microvesicular hepatic steatosis (HP:0001414)	2.23177511
47	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.22085581
48	Dicarboxylic aciduria (HP:0003215)	2.22085581
49	Stomatitis (HP:0010280)	2.22027196
50	Panhypogammaglobulinemia (HP:0003139)	2.21458483
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20640956
52	Hyperthyroidism (HP:0000836)	2.19876582
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.18507693
54	Abnormality of renal resorption (HP:0011038)	2.18477906
55	Progressive microcephaly (HP:0000253)	2.16693795
56	Type I transferrin isoform profile (HP:0003642)	2.10857304
57	Congenital stationary night blindness (HP:0007642)	2.09380132
58	Absent thumb (HP:0009777)	2.08262973
59	Emotional lability (HP:0000712)	2.07148260
60	Pancytopenia (HP:0001876)	2.06588101
61	Methylmalonic aciduria (HP:0012120)	2.00538162
62	Severe combined immunodeficiency (HP:0004430)	1.98462072
63	Hypertensive crisis (HP:0100735)	1.95513752
64	Esophageal neoplasm (HP:0100751)	1.95310561
65	Neoplasm of head and neck (HP:0012288)	1.95310561
66	Lethargy (HP:0001254)	1.95261139
67	Muscle fiber atrophy (HP:0100295)	1.91684556
68	Petechiae (HP:0000967)	1.91333130
69	Leukodystrophy (HP:0002415)	1.88491939
70	Hyperphosphaturia (HP:0003109)	1.88266782
71	Hyperglycinemia (HP:0002154)	1.88087028
72	Generalized aminoaciduria (HP:0002909)	1.87755967
73	Truncus arteriosus (HP:0001660)	1.87717281
74	Glycosuria (HP:0003076)	1.87115476
75	Abnormality of urine glucose concentration (HP:0011016)	1.87115476
76	Abnormal protein glycosylation (HP:0012346)	1.87028754
77	Abnormal glycosylation (HP:0012345)	1.87028754
78	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87028754
79	Abnormal protein N-linked glycosylation (HP:0012347)	1.87028754
80	Autoimmune hemolytic anemia (HP:0001890)	1.84434557
81	Concave nail (HP:0001598)	1.81158281
82	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.81061871
83	Hypoplasia of the uterus (HP:0000013)	1.79176389
84	Abnormality of T cell physiology (HP:0011840)	1.77752473
85	Ragged-red muscle fibers (HP:0003200)	1.76013551
86	Severe visual impairment (HP:0001141)	1.75862451
87	Gastrointestinal infarctions (HP:0005244)	1.75545178
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74349777
89	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.74064564
90	Neutropenia (HP:0001875)	1.70446141
91	CNS demyelination (HP:0007305)	1.68210620
92	Seborrheic dermatitis (HP:0001051)	1.67408379
93	Asplenia (HP:0001746)	1.66895378
94	Mediastinal lymphadenopathy (HP:0100721)	1.66000271
95	Granulocytopenia (HP:0001913)	1.65670528
96	Abnormality of T cells (HP:0002843)	1.63795881
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.61937230
98	Abnormality of reticulocytes (HP:0004312)	1.61651970
99	Increased IgM level (HP:0003496)	1.61238723
100	Encephalitis (HP:0002383)	1.60969693

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.93044494
2	BCKDK	3.50759050
3	MAP4K1	3.33729060
4	TESK2	3.30578962
5	KDR	2.86015410
6	TXK	2.85694038
7	VRK2	2.36854107
8	LRRK2	2.31688848
9	FES	2.06465445
10	CDK19	1.86052780
11	TLK1	1.84516880
12	STK16	1.79670475
13	PIM2	1.79074609
14	KIT	1.75619081
15	MAP3K11	1.62792638
16	BUB1	1.61390604
17	TNK2	1.60495597
18	PASK	1.58732358
19	ABL2	1.46624557
20	GRK6	1.45892562
21	IKBKB	1.42705804
22	ARAF	1.40451771
23	TEC	1.38949880
24	ERN1	1.34341075
25	IRAK3	1.34156564
26	TAOK3	1.33071049
27	BTK	1.31427386
28	GRK1	1.31019846
29	TAOK2	1.26175880
30	IRAK4	1.24991947
31	ZAK	1.22811703
32	SYK	1.20981092
33	MAP4K2	1.15403418
34	ITK	1.13794748
35	ADRBK2	1.13638419
36	ILK	1.12078023
37	MUSK	1.10926275
38	JAK3	1.06962034
39	RPS6KA5	1.03315041
40	TYK2	0.93891986
41	NME1	0.92813991
42	MAP2K3	0.92419185
43	PRPF4B	0.87939535
44	PIM1	0.86943596
45	LYN	0.86104584
46	MARK3	0.84838582
47	VRK1	0.83766428
48	AURKA	0.82946016
49	CCNB1	0.82500310
50	RPS6KA4	0.81957574
51	RIPK4	0.81623853
52	PDK2	0.78913615
53	IKBKE	0.77761120
54	TBK1	0.77417603
55	PRKCQ	0.77170268
56	TESK1	0.77013775
57	DYRK2	0.75841132
58	LCK	0.71479772
59	RPS6KB2	0.69550300
60	STK4	0.68457688
61	MAP3K13	0.68101983
62	BRAF	0.65132618
63	CSNK2A2	0.64614968
64	HCK	0.63882066
65	CSNK2A1	0.63478897
66	PRKD2	0.60534505
67	MAP2K6	0.59170749
68	CAMKK2	0.58283502
69	CDK4	0.55538713
70	PAK1	0.54958683
71	PRKD3	0.52986780
72	DAPK1	0.51964233
73	MAP2K2	0.51294685
74	CDK8	0.50945679
75	PIK3CG	0.50934438
76	NUAK1	0.49527924
77	ZAP70	0.48291203
78	SIK2	0.48283413
79	TAOK1	0.47802176
80	CSF1R	0.47225819
81	RPS6KA6	0.45014682
82	TIE1	0.44926574
83	MAPKAPK3	0.43859846
84	RPS6KC1	0.42155447
85	RPS6KL1	0.42155447
86	CAMKK1	0.41792880
87	PRKCI	0.39921725
88	PINK1	0.39429759
89	INSRR	0.39394398
90	MAP3K8	0.39263825
91	OBSCN	0.38905416
92	WNK4	0.38473753
93	DAPK3	0.37845989
94	ADRBK1	0.36969888
95	MAPK12	0.36249809
96	MAPK11	0.36093620
97	CSNK1G3	0.35724062
98	CSK	0.35710908
99	ATR	0.34868335
100	EEF2K	0.34360458

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.60192288
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.72209602
3	Parkinsons disease_Homo sapiens_hsa05012	3.98517463
4	RNA polymerase_Homo sapiens_hsa03020	2.81706260
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.76557499
6	Huntingtons disease_Homo sapiens_hsa05016	2.72799511
7	Sulfur relay system_Homo sapiens_hsa04122	2.57374129
8	Alzheimers disease_Homo sapiens_hsa05010	2.56847220
9	Proteasome_Homo sapiens_hsa03050	2.56423317
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.40246775
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.06661577
12	Base excision repair_Homo sapiens_hsa03410	2.03806101
13	DNA replication_Homo sapiens_hsa03030	2.01854665
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73128739
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.69185876
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65028329
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54182017
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49904712
19	Allograft rejection_Homo sapiens_hsa05330	1.47307237
20	Spliceosome_Homo sapiens_hsa03040	1.44602168
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.40650801
22	Protein export_Homo sapiens_hsa03060	1.33491036
23	Homologous recombination_Homo sapiens_hsa03440	1.32935946
24	One carbon pool by folate_Homo sapiens_hsa00670	1.32721711
25	Asthma_Homo sapiens_hsa05310	1.31515368
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.31370080
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29791147
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15440916
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13682661
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.11332294
31	Purine metabolism_Homo sapiens_hsa00230	1.11053090
32	Sulfur metabolism_Homo sapiens_hsa00920	1.04480422
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.04260041
34	Mismatch repair_Homo sapiens_hsa03430	1.01498030
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90111437
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88904499
37	Antigen processing and presentation_Homo sapiens_hsa04612	0.87020006
38	Fatty acid elongation_Homo sapiens_hsa00062	0.86107941
39	Folate biosynthesis_Homo sapiens_hsa00790	0.84119776
40	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82986001
41	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82974175
42	Glutathione metabolism_Homo sapiens_hsa00480	0.82275496
43	RNA degradation_Homo sapiens_hsa03018	0.82162148
44	Metabolic pathways_Homo sapiens_hsa01100	0.80559310
45	Rheumatoid arthritis_Homo sapiens_hsa05323	0.78912492
46	RNA transport_Homo sapiens_hsa03013	0.75661816
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68719713
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67540308
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.66980453
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66429790
51	Basal transcription factors_Homo sapiens_hsa03022	0.63120937
52	Peroxisome_Homo sapiens_hsa04146	0.62179262
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59071658
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58402155
55	Regulation of autophagy_Homo sapiens_hsa04140	0.55293116
56	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53949041
57	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.53725119
58	Phototransduction_Homo sapiens_hsa04744	0.51941177
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51214293
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49458088
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47672618
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44677904
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44238503
64	Viral myocarditis_Homo sapiens_hsa05416	0.43281049
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.42874054
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.42622065
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42119853
68	Malaria_Homo sapiens_hsa05144	0.41953943
69	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40368397
70	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40125960
71	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.39854396
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37541024
73	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37194654
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37001151
75	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36297793
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35618847
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35270762
78	Herpes simplex infection_Homo sapiens_hsa05168	0.34860771
79	Leishmaniasis_Homo sapiens_hsa05140	0.34150543
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34130805
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.31992389
82	Other glycan degradation_Homo sapiens_hsa00511	0.30674389
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.30385767
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30250930
85	Propanoate metabolism_Homo sapiens_hsa00640	0.26989391
86	Measles_Homo sapiens_hsa05162	0.26204266
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.25690069
88	Carbon metabolism_Homo sapiens_hsa01200	0.24624825
89	Galactose metabolism_Homo sapiens_hsa00052	0.23853917
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22081665
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.20990539
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.19002963
93	Olfactory transduction_Homo sapiens_hsa04740	0.18558715
94	Pentose phosphate pathway_Homo sapiens_hsa00030	0.17370583
95	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.17171074
96	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.15680829
97	HTLV-I infection_Homo sapiens_hsa05166	0.15604128
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.15516076
99	Acute myeloid leukemia_Homo sapiens_hsa05221	0.15242553
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.14289787

RPS28P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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