ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.99498000
2	ribosomal small subunit assembly (GO:0000028)	8.79814579
3	translational termination (GO:0006415)	8.64228942
4	ribosomal small subunit biogenesis (GO:0042274)	7.97246868
5	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	7.45611953
6	translational elongation (GO:0006414)	7.30962749
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.11452433
8	cotranslational protein targeting to membrane (GO:0006613)	6.97851230
9	protein targeting to ER (GO:0045047)	6.97093393
10	maturation of SSU-rRNA (GO:0030490)	6.88339827
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.67930887
12	pyrimidine nucleotide catabolic process (GO:0006244)	6.61993996
13	cellular protein complex disassembly (GO:0043624)	6.56356050
14	protein localization to endoplasmic reticulum (GO:0070972)	6.54860183
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.45064601
16	viral life cycle (GO:0019058)	6.35905291
17	translational initiation (GO:0006413)	5.58991981
18	protein complex disassembly (GO:0043241)	5.58099614
19	macromolecular complex disassembly (GO:0032984)	5.20746525
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.06278361
21	ATP synthesis coupled proton transport (GO:0015986)	5.06278361
22	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.90444048
23	protein targeting to membrane (GO:0006612)	4.69398376
24	ribosomal large subunit biogenesis (GO:0042273)	4.51981974
25	protein complex biogenesis (GO:0070271)	4.49516488
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.41704764
27	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.38429534
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.37869279
29	NADH dehydrogenase complex assembly (GO:0010257)	4.37869279
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.37869279
31	translation (GO:0006412)	4.30165727
32	chaperone-mediated protein transport (GO:0072321)	4.18563655
33	mRNA catabolic process (GO:0006402)	4.16835495
34	protein neddylation (GO:0045116)	4.15749644
35	base-excision repair, AP site formation (GO:0006285)	4.09575520
36	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.03584476
37	substrate-independent telencephalic tangential migration (GO:0021826)	4.03584476
38	mitochondrial respiratory chain complex assembly (GO:0033108)	4.02559201
39	behavioral response to nicotine (GO:0035095)	3.99611434
40	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.88614855
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.87193064
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.86228302
43	neuron fate determination (GO:0048664)	3.85327466
44	cellular component biogenesis (GO:0044085)	3.84995763
45	tongue development (GO:0043586)	3.83067883
46	respiratory electron transport chain (GO:0022904)	3.78986068
47	RNA catabolic process (GO:0006401)	3.75617902
48	ubiquinone biosynthetic process (GO:0006744)	3.74764760
49	electron transport chain (GO:0022900)	3.73792743
50	iron-sulfur cluster assembly (GO:0016226)	3.65755235
51	metallo-sulfur cluster assembly (GO:0031163)	3.65755235
52	GTP biosynthetic process (GO:0006183)	3.62391892
53	regulation of cellular respiration (GO:0043457)	3.52213885
54	deoxyribonucleotide catabolic process (GO:0009264)	3.52081198
55	nonmotile primary cilium assembly (GO:0035058)	3.50624093
56	quinone biosynthetic process (GO:1901663)	3.38302200
57	ubiquinone metabolic process (GO:0006743)	3.35139454
58	somite development (GO:0061053)	3.34110720
59	deoxyribose phosphate catabolic process (GO:0046386)	3.29130966
60	negative regulation of mast cell activation (GO:0033004)	3.17887008
61	UTP biosynthetic process (GO:0006228)	3.16953322
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.14681911
63	transmission of nerve impulse (GO:0019226)	3.14148310
64	hypothalamus development (GO:0021854)	3.13980705
65	establishment of protein localization to membrane (GO:0090150)	3.09788585
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.07752056
67	cell proliferation in forebrain (GO:0021846)	3.05954193
68	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.04706906
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.04706906
70	ATP biosynthetic process (GO:0006754)	2.99615601
71	pattern specification involved in kidney development (GO:0061004)	2.97250496
72	protein targeting (GO:0006605)	2.96439360
73	hydrogen ion transmembrane transport (GO:1902600)	2.94742414
74	cytochrome complex assembly (GO:0017004)	2.92965835
75	ncRNA 3-end processing (GO:0043628)	2.92874093
76	UTP metabolic process (GO:0046051)	2.91700898
77	protein-cofactor linkage (GO:0018065)	2.90715920
78	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.90544496
79	segment specification (GO:0007379)	2.88394353
80	positive regulation of T cell apoptotic process (GO:0070234)	2.85726392
81	rRNA catabolic process (GO:0016075)	2.85202990
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.84700499
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.83501279
84	spinal cord association neuron differentiation (GO:0021527)	2.80880354
85	establishment of protein localization to organelle (GO:0072594)	2.79465073
86	rRNA processing (GO:0006364)	2.79178236
87	respiratory chain complex IV assembly (GO:0008535)	2.77798482
88	intraciliary transport (GO:0042073)	2.76618481
89	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.75346653
90	rRNA metabolic process (GO:0016072)	2.74934106
91	positive regulation of histone H3-K4 methylation (GO:0051571)	2.72550804
92	pyrimidine nucleobase catabolic process (GO:0006208)	2.68344564
93	protein localization to membrane (GO:0072657)	2.66504813
94	regulation of mitochondrial translation (GO:0070129)	2.62933998
95	positive regulation of respiratory burst (GO:0060267)	2.58750692
96	proton transport (GO:0015992)	2.58468529
97	hydrogen transport (GO:0006818)	2.52114323
98	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.51932900
99	2-deoxyribonucleotide metabolic process (GO:0009394)	2.50773077
100	CTP metabolic process (GO:0046036)	2.50725248

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.49102254
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.95575462
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.07602127
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66172444
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.54628600
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.53358419
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.49360266
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.40852226
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.36343551
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.25632766
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14285109
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.08368182
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00913186
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.96245244
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.95208447
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.92194456
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90151691
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89255327
19	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.82561161
20	VDR_22108803_ChIP-Seq_LS180_Human	1.81982835
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.79480133
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.79458802
23	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.71730753
24	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.69346020
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.65581348
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64724474
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.64229652
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63502370
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62071173
30	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.61633951
31	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.60817386
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.55533496
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.55401961
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.51146183
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.49036503
36	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.46600087
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.40725321
38	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.40667959
39	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.40667959
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.40491737
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40062262
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.37436691
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.36293636
44	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.36031137
45	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.35027013
46	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.33858600
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33467667
48	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.32356720
49	ERA_21632823_ChIP-Seq_H3396_Human	1.30807545
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30239089
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28459450
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27981254
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26452468
54	CTCF_20526341_ChIP-Seq_ESCs_Human	1.24940163
55	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.24369052
56	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20876321
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20536428
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20188839
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19327785
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18450316
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.17777861
62	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16324406
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16051960
64	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15520965
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15402161
66	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13436994
67	FOXP3_21729870_ChIP-Seq_TREG_Human	1.12718280
68	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.12186218
69	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.12012716
70	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.11058723
71	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.08319734
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.06847442
73	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06374976
74	CTCF_27219007_Chip-Seq_Bcells_Human	1.05970603
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04621666
76	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.04501465
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04463179
78	NCOR_22424771_ChIP-Seq_293T_Human	1.04429275
79	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.03783809
80	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.03010763
81	TP53_22573176_ChIP-Seq_HFKS_Human	1.00159696
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00040782
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99110237
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97839428
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95958195
86	AR_20517297_ChIP-Seq_VCAP_Human	0.95869786
87	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.95667670
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.94937203
89	SA1_27219007_Chip-Seq_Bcells_Human	0.94905651
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94225114
91	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.93540828
92	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.91872995
93	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.91161165
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.90814843
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.90302287
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90220765
97	P68_20966046_ChIP-Seq_HELA_Human	0.90152036
98	FUS_26573619_Chip-Seq_HEK293_Human	0.90128854
99	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89812612
100	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.89619779

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.35607212
2	MP0006292_abnormal_olfactory_placode	5.03212381
3	MP0002653_abnormal_ependyma_morphology	4.17953893
4	MP0002163_abnormal_gland_morphology	3.11727222
5	MP0008789_abnormal_olfactory_epithelium	2.74862916
6	MP0003787_abnormal_imprinting	2.48353587
7	MP0004142_abnormal_muscle_tone	2.48347304
8	MP0003646_muscle_fatigue	2.44053218
9	MP0003123_paternal_imprinting	2.22953884
10	MP0005499_abnormal_olfactory_system	2.21559978
11	MP0005394_taste/olfaction_phenotype	2.21559978
12	MP0005646_abnormal_pituitary_gland	2.20534845
13	MP0003122_maternal_imprinting	2.19271036
14	MP0004147_increased_porphyrin_level	2.17309906
15	MP0010030_abnormal_orbit_morphology	2.12418829
16	MP0001293_anophthalmia	2.02693219
17	MP0008057_abnormal_DNA_replication	1.92113955
18	MP0003880_abnormal_central_pattern	1.86280726
19	MP0000049_abnormal_middle_ear	1.86095265
20	MP0003136_yellow_coat_color	1.80986787
21	MP0005379_endocrine/exocrine_gland_phen	1.59445429
22	MP0004885_abnormal_endolymph	1.59218310
23	MP0000778_abnormal_nervous_system	1.58393905
24	MP0002938_white_spotting	1.53397014
25	MP0002102_abnormal_ear_morphology	1.52783944
26	MP0002095_abnormal_skin_pigmentation	1.52618230
27	MP0006276_abnormal_autonomic_nervous	1.51598363
28	MP0003121_genomic_imprinting	1.44766760
29	MP0005551_abnormal_eye_electrophysiolog	1.41087658
30	MP0005084_abnormal_gallbladder_morpholo	1.36890238
31	MP0005195_abnormal_posterior_eye	1.36342999
32	MP0002837_dystrophic_cardiac_calcinosis	1.32114939
33	MP0000631_abnormal_neuroendocrine_gland	1.30795410
34	MP0004133_heterotaxia	1.29372112
35	MP0002557_abnormal_social/conspecific_i	1.24712520
36	MP0001529_abnormal_vocalization	1.21655082
37	MP0005377_hearing/vestibular/ear_phenot	1.21277994
38	MP0003878_abnormal_ear_physiology	1.21277994
39	MP0001348_abnormal_lacrimal_gland	1.20477311
40	MP0002234_abnormal_pharynx_morphology	1.14343181
41	MP0001286_abnormal_eye_development	1.13605920
42	MP0000026_abnormal_inner_ear	1.12429241
43	MP0004145_abnormal_muscle_electrophysio	1.12174765
44	MP0002160_abnormal_reproductive_system	1.11338555
45	MP0002184_abnormal_innervation	1.11031760
46	MP0000955_abnormal_spinal_cord	1.10358214
47	MP0002272_abnormal_nervous_system	1.09169830
48	MP0002752_abnormal_somatic_nervous	1.04163036
49	MP0002233_abnormal_nose_morphology	1.02700667
50	MP0009053_abnormal_anal_canal	1.01142001
51	MP0001905_abnormal_dopamine_level	1.00873717
52	MP0008058_abnormal_DNA_repair	1.00524128
53	MP0008775_abnormal_heart_ventricle	0.99163297
54	MP0001485_abnormal_pinna_reflex	0.98570505
55	MP0001188_hyperpigmentation	0.97510967
56	MP0000678_abnormal_parathyroid_gland	0.97326063
57	MP0003186_abnormal_redox_activity	0.96516129
58	MP0002733_abnormal_thermal_nociception	0.96278757
59	MP0001984_abnormal_olfaction	0.96176141
60	MP0001486_abnormal_startle_reflex	0.95654556
61	MP0002638_abnormal_pupillary_reflex	0.94352095
62	MP0005671_abnormal_response_to	0.94290135
63	MP0002876_abnormal_thyroid_physiology	0.93315328
64	MP0001970_abnormal_pain_threshold	0.93212670
65	MP0000566_synostosis	0.92408342
66	MP0001968_abnormal_touch/_nociception	0.92398916
67	MP0003942_abnormal_urinary_system	0.92242887
68	MP0001324_abnormal_eye_pigmentation	0.91269853
69	MP0008875_abnormal_xenobiotic_pharmacok	0.89072425
70	MP0002249_abnormal_larynx_morphology	0.89011745
71	MP0002210_abnormal_sex_determination	0.88829560
72	MP0003635_abnormal_synaptic_transmissio	0.86165851
73	MP0002736_abnormal_nociception_after	0.84263418
74	MP0001963_abnormal_hearing_physiology	0.83889070
75	MP0009745_abnormal_behavioral_response	0.82621193
76	MP0008877_abnormal_DNA_methylation	0.82025512
77	MP0003938_abnormal_ear_development	0.81518933
78	MP0005389_reproductive_system_phenotype	0.80854139
79	MP0001663_abnormal_digestive_system	0.80696474
80	MP0002063_abnormal_learning/memory/cond	0.80689025
81	MP0008872_abnormal_physiological_respon	0.79366600
82	MP0002138_abnormal_hepatobiliary_system	0.78271103
83	MP0005645_abnormal_hypothalamus_physiol	0.77998965
84	MP0004858_abnormal_nervous_system	0.77622711
85	MP0002572_abnormal_emotion/affect_behav	0.75220080
86	MP0001119_abnormal_female_reproductive	0.74291291
87	MP0001270_distended_abdomen	0.73503366
88	MP0003755_abnormal_palate_morphology	0.71955689
89	MP0003283_abnormal_digestive_organ	0.71593441
90	MP0006072_abnormal_retinal_apoptosis	0.71436039
91	MP0002277_abnormal_respiratory_mucosa	0.71196414
92	MP0000685_abnormal_immune_system	0.70881896
93	MP0000613_abnormal_salivary_gland	0.70416311
94	MP0001440_abnormal_grooming_behavior	0.68404393
95	MP0003567_abnormal_fetal_cardiomyocyte	0.68075416
96	MP0002116_abnormal_craniofacial_bone	0.66964299
97	MP0003937_abnormal_limbs/digits/tail_de	0.66885677
98	MP0004130_abnormal_muscle_cell	0.66813185
99	MP0002882_abnormal_neuron_morphology	0.66418638
100	MP0004742_abnormal_vestibular_system	0.64842583

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.52375179
2	Reticulocytopenia (HP:0001896)	5.40827139
3	Abnormal number of erythroid precursors (HP:0012131)	4.49041688
4	Macrocytic anemia (HP:0001972)	4.18424202
5	Acute necrotizing encephalopathy (HP:0006965)	3.98915317
6	Pancreatic fibrosis (HP:0100732)	3.90702717
7	Mitochondrial inheritance (HP:0001427)	3.77336613
8	Molar tooth sign on MRI (HP:0002419)	3.76633678
9	Abnormality of midbrain morphology (HP:0002418)	3.76633678
10	Increased CSF lactate (HP:0002490)	3.64061029
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57784401
12	True hermaphroditism (HP:0010459)	3.37091603
13	Acute encephalopathy (HP:0006846)	3.35784900
14	Increased hepatocellular lipid droplets (HP:0006565)	3.27141841
15	Pallor (HP:0000980)	3.21703277
16	Hepatocellular necrosis (HP:0001404)	3.18986775
17	Progressive macrocephaly (HP:0004481)	3.12887062
18	Type II lissencephaly (HP:0007260)	3.11259493
19	Lipid accumulation in hepatocytes (HP:0006561)	3.05109676
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.04622155
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.02640876
22	Pancreatic cysts (HP:0001737)	3.01360941
23	Sclerocornea (HP:0000647)	2.89507246
24	Rib fusion (HP:0000902)	2.88723032
25	Hepatic necrosis (HP:0002605)	2.88589373
26	Nephronophthisis (HP:0000090)	2.88340549
27	Septo-optic dysplasia (HP:0100842)	2.84835521
28	Increased intramyocellular lipid droplets (HP:0012240)	2.83987939
29	Renal Fanconi syndrome (HP:0001994)	2.74291276
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.65620175
31	Absent thumb (HP:0009777)	2.62823658
32	Medial flaring of the eyebrow (HP:0010747)	2.58860367
33	Increased serum lactate (HP:0002151)	2.53859021
34	Cerebral edema (HP:0002181)	2.49340031
35	Congenital stationary night blindness (HP:0007642)	2.47696651
36	Myokymia (HP:0002411)	2.45272348
37	Hyperglycinemia (HP:0002154)	2.45049203
38	Pendular nystagmus (HP:0012043)	2.44536192
39	Abnormality of alanine metabolism (HP:0010916)	2.44516034
40	Hyperalaninemia (HP:0003348)	2.44516034
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.44516034
42	3-Methylglutaconic aciduria (HP:0003535)	2.41575439
43	Anencephaly (HP:0002323)	2.39269580
44	Increased muscle lipid content (HP:0009058)	2.38126666
45	Abnormality of renal resorption (HP:0011038)	2.36378329
46	Depressed nasal ridge (HP:0000457)	2.36361776
47	Absent septum pellucidum (HP:0001331)	2.31037252
48	Hypoplasia of the radius (HP:0002984)	2.29193276
49	Abnormality of the renal medulla (HP:0100957)	2.27542445
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.25700135
51	Optic disc pallor (HP:0000543)	2.23288915
52	Gait imbalance (HP:0002141)	2.23240231
53	11 pairs of ribs (HP:0000878)	2.20210232
54	Asplenia (HP:0001746)	2.19543608
55	Stenosis of the external auditory canal (HP:0000402)	2.19294765
56	Cystic liver disease (HP:0006706)	2.18361460
57	Oligodactyly (hands) (HP:0001180)	2.15788355
58	Cerebellar dysplasia (HP:0007033)	2.11506959
59	Anophthalmia (HP:0000528)	2.09613707
60	Postaxial foot polydactyly (HP:0001830)	2.09496670
61	Congenital primary aphakia (HP:0007707)	2.09284857
62	Exertional dyspnea (HP:0002875)	2.08006516
63	Nephrogenic diabetes insipidus (HP:0009806)	2.04104573
64	Oligodactyly (HP:0012165)	2.00905578
65	Maternal diabetes (HP:0009800)	1.97334511
66	Colon cancer (HP:0003003)	1.95885863
67	Lactic acidosis (HP:0003128)	1.95669236
68	Decreased circulating renin level (HP:0003351)	1.95073704
69	Congenital hepatic fibrosis (HP:0002612)	1.94283852
70	Hyperthyroidism (HP:0000836)	1.94045021
71	Forearm undergrowth (HP:0009821)	1.93168245
72	Polyuria (HP:0000103)	1.92855278
73	Decreased central vision (HP:0007663)	1.90012343
74	Optic nerve hypoplasia (HP:0000609)	1.87421890
75	Abolished electroretinogram (ERG) (HP:0000550)	1.87192376
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86670264
77	Holoprosencephaly (HP:0001360)	1.84045145
78	Abnormality of reticulocytes (HP:0004312)	1.80000500
79	Hyperphosphaturia (HP:0003109)	1.79030898
80	Abnormality of DNA repair (HP:0003254)	1.79015174
81	Annular pancreas (HP:0001734)	1.78437778
82	Respiratory failure (HP:0002878)	1.76788444
83	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76786154
84	Optic nerve coloboma (HP:0000588)	1.76762678
85	Tubular atrophy (HP:0000092)	1.76510730
86	Chronic hepatic failure (HP:0100626)	1.76431773
87	Lethargy (HP:0001254)	1.75945277
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74999171
89	Lissencephaly (HP:0001339)	1.74912276
90	Pachygyria (HP:0001302)	1.73372788
91	Abnormality of the labia minora (HP:0012880)	1.73331155
92	Deep palmar crease (HP:0006191)	1.72869942
93	Absent/shortened dynein arms (HP:0200106)	1.72745367
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72745367
95	Abnormality of urine glucose concentration (HP:0011016)	1.71969741
96	Glycosuria (HP:0003076)	1.71969741
97	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.71812219
98	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.71812219
99	Hyperactive renin-angiotensin system (HP:0000841)	1.71742426
100	Renal salt wasting (HP:0000127)	1.71265106

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	5.14402704
2	STK16	3.99753166
3	BCKDK	3.31983818
4	WNK4	2.92405720
5	CDK19	2.69571117
6	VRK2	2.37775834
7	DYRK2	2.23563013
8	TXK	2.17758354
9	TLK1	1.91866775
10	PIK3CA	1.85533244
11	GRK1	1.78423415
12	MAP3K11	1.65609445
13	PINK1	1.62004960
14	ADRBK2	1.61675312
15	EPHB2	1.61589073
16	MAP4K2	1.60401461
17	LRRK2	1.58482449
18	PDK2	1.56616084
19	ZAK	1.53173291
20	NME1	1.45905477
21	TYRO3	1.43340137
22	TIE1	1.40806796
23	BTK	1.39908927
24	PRKCG	1.32009370
25	CAMK1D	1.25833496
26	PRKCH	1.25035097
27	KDR	1.22556221
28	NTRK2	1.18395892
29	NEK1	1.15481670
30	EPHA4	1.13967908
31	CAMK1	1.10254139
32	CAMKK2	1.09053404
33	LIMK1	1.06710950
34	MAP3K9	1.06664518
35	MARK1	1.05557975
36	CDC7	1.01261365
37	NME2	0.99907721
38	CDK8	0.99875058
39	NEK2	0.97987984
40	BRAF	0.97513947
41	DYRK1B	0.96375659
42	STK39	0.95444424
43	VRK1	0.93750461
44	ARAF	0.93633596
45	MAPK15	0.91853440
46	CAMKK1	0.90651754
47	MINK1	0.89121723
48	MAPK13	0.88913889
49	ADRBK1	0.88364984
50	WNK3	0.86470157
51	NUAK1	0.86153141
52	CASK	0.83836872
53	DAPK3	0.82465670
54	CHEK2	0.82074955
55	AURKB	0.81815855
56	PASK	0.79388473
57	TAOK3	0.76081030
58	WNK1	0.74844483
59	MAP4K1	0.69964884
60	PAK3	0.69180177
61	ITK	0.68906210
62	RPS6KA5	0.65681581
63	CSNK2A2	0.64839299
64	PRKACA	0.64554560
65	MAP2K7	0.62445959
66	TNIK	0.62150339
67	AURKA	0.61154567
68	PRKD3	0.60956770
69	RPS6KA6	0.60810544
70	PRKCI	0.60488735
71	BMPR1B	0.60265368
72	STK11	0.59365768
73	MARK2	0.58892235
74	TESK2	0.58851085
75	INSRR	0.58038767
76	CAMK1G	0.57614256
77	ABL2	0.57405396
78	CSNK2A1	0.57216129
79	PRKCQ	0.55414614
80	CSNK1E	0.50432503
81	SYK	0.50261799
82	PIM2	0.48979601
83	TEC	0.48224168
84	PRKCZ	0.46251417
85	FRK	0.45586475
86	CSNK1A1	0.43148957
87	MOS	0.42999983
88	RPS6KL1	0.41310242
89	RPS6KC1	0.41310242
90	PRKCA	0.41235342
91	PIM1	0.41189541
92	OBSCN	0.39924164
93	CAMK2A	0.39604221
94	PLK4	0.39585587
95	DYRK3	0.38612750
96	CDK11A	0.38134019
97	PLK1	0.37103727
98	CSNK1G2	0.36458015
99	GRK7	0.36421659
100	PAK6	0.35914158

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.74297874
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.56089967
3	Parkinsons disease_Homo sapiens_hsa05012	3.76968825
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.04468284
5	Huntingtons disease_Homo sapiens_hsa05016	2.95324723
6	Alzheimers disease_Homo sapiens_hsa05010	2.52851361
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.48338790
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.48270043
9	Sulfur relay system_Homo sapiens_hsa04122	2.45760060
10	Basal transcription factors_Homo sapiens_hsa03022	1.92351411
11	One carbon pool by folate_Homo sapiens_hsa00670	1.88810058
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81166935
13	RNA polymerase_Homo sapiens_hsa03020	1.79476464
14	Phototransduction_Homo sapiens_hsa04744	1.63335757
15	Folate biosynthesis_Homo sapiens_hsa00790	1.56227110
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55839467
17	RNA degradation_Homo sapiens_hsa03018	1.46306612
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43862534
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40179659
20	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37670181
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.27164213
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25118536
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21352676
24	Proteasome_Homo sapiens_hsa03050	1.18500600
25	Nicotine addiction_Homo sapiens_hsa05033	1.18138853
26	Butanoate metabolism_Homo sapiens_hsa00650	1.16814977
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.15540766
28	Protein export_Homo sapiens_hsa03060	1.14450759
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.02987000
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02983837
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99025886
32	Base excision repair_Homo sapiens_hsa03410	0.97925160
33	Homologous recombination_Homo sapiens_hsa03440	0.96855682
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96097393
35	Steroid biosynthesis_Homo sapiens_hsa00100	0.94282303
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91790092
37	Ether lipid metabolism_Homo sapiens_hsa00565	0.91608804
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90733948
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.89210379
40	Purine metabolism_Homo sapiens_hsa00230	0.87293982
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.86950380
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.80588272
43	Propanoate metabolism_Homo sapiens_hsa00640	0.79294783
44	Peroxisome_Homo sapiens_hsa04146	0.79051671
45	Metabolic pathways_Homo sapiens_hsa01100	0.78467557
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77760449
47	Morphine addiction_Homo sapiens_hsa05032	0.76539508
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.76412633
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73054915
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71623033
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.71092770
52	Sulfur metabolism_Homo sapiens_hsa00920	0.70341028
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70221104
54	Mismatch repair_Homo sapiens_hsa03430	0.68208715
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67487174
56	DNA replication_Homo sapiens_hsa03030	0.65642103
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62856163
58	Regulation of autophagy_Homo sapiens_hsa04140	0.61793327
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60744138
60	RNA transport_Homo sapiens_hsa03013	0.60435179
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60333933
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58307202
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58213399
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58196944
65	Olfactory transduction_Homo sapiens_hsa04740	0.58180439
66	Spliceosome_Homo sapiens_hsa03040	0.55562367
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54773856
68	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50705801
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50351978
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47709391
71	Axon guidance_Homo sapiens_hsa04360	0.47079996
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.45415413
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.45362736
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43997632
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43078582
76	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39366013
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.38320202
78	Insulin secretion_Homo sapiens_hsa04911	0.38211400
79	Retinol metabolism_Homo sapiens_hsa00830	0.37350416
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34249994
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33931661
82	Fatty acid degradation_Homo sapiens_hsa00071	0.33774425
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.33427277
84	Taste transduction_Homo sapiens_hsa04742	0.32747367
85	Notch signaling pathway_Homo sapiens_hsa04330	0.32532615
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32252896
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31826734
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31740851
89	Asthma_Homo sapiens_hsa05310	0.31725164
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29596034
91	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.27817002
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.27340536
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26582987
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25538745
95	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25505771
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25309424
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.22202721
98	Serotonergic synapse_Homo sapiens_hsa04726	0.22168037
99	GABAergic synapse_Homo sapiens_hsa04727	0.21193292
100	Caffeine metabolism_Homo sapiens_hsa00232	0.20449615

RPS2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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