RPS2P24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.05978243
2viral transcription (GO:0019083)8.02447647
3translational termination (GO:0006415)7.70533322
4ribosomal small subunit biogenesis (GO:0042274)7.22199080
5maturation of SSU-rRNA (GO:0030490)7.12454699
6translational elongation (GO:0006414)6.56694030
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.37535875
8protein targeting to ER (GO:0045047)6.26394351
9cotranslational protein targeting to membrane (GO:0006613)6.26228068
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.95969167
11protein localization to endoplasmic reticulum (GO:0070972)5.85806775
12cellular protein complex disassembly (GO:0043624)5.77023620
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.72672424
14ATP synthesis coupled proton transport (GO:0015986)5.72672424
15viral life cycle (GO:0019058)5.72286051
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.63357934
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.34261488
18translational initiation (GO:0006413)5.16987680
19chaperone-mediated protein transport (GO:0072321)4.96858339
20protein complex disassembly (GO:0043241)4.80274143
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.73239980
22ribosomal large subunit biogenesis (GO:0042273)4.72637887
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.56640940
24macromolecular complex disassembly (GO:0032984)4.50008323
25DNA deamination (GO:0045006)4.47293599
26protein neddylation (GO:0045116)4.23732800
27protein targeting to membrane (GO:0006612)4.20336286
28translation (GO:0006412)4.20223058
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19372191
30protein complex biogenesis (GO:0070271)4.13143407
31pyrimidine nucleotide catabolic process (GO:0006244)4.13122908
32respiratory electron transport chain (GO:0022904)4.11913642
33electron transport chain (GO:0022900)4.06226884
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.98579720
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.98579720
36NADH dehydrogenase complex assembly (GO:0010257)3.98579720
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.92352298
38mitochondrial respiratory chain complex assembly (GO:0033108)3.71755495
39ribonucleoprotein complex biogenesis (GO:0022613)3.69885954
40mRNA catabolic process (GO:0006402)3.69744657
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.68864351
42cellular component biogenesis (GO:0044085)3.64209031
43deoxyribose phosphate catabolic process (GO:0046386)3.56270423
44base-excision repair, AP site formation (GO:0006285)3.41279124
45RNA catabolic process (GO:0006401)3.38254182
46negative regulation of mast cell activation (GO:0033004)3.36671618
47cytidine deamination (GO:0009972)3.35407588
48cytidine metabolic process (GO:0046087)3.35407588
49cytidine catabolic process (GO:0006216)3.35407588
50deoxyribonucleotide catabolic process (GO:0009264)3.31185793
51ATP biosynthetic process (GO:0006754)3.30695852
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22479847
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22268675
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16132009
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16132009
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.14275315
57mature B cell differentiation involved in immune response (GO:0002313)3.14144357
58mature B cell differentiation (GO:0002335)3.11209657
59ubiquinone biosynthetic process (GO:0006744)3.00798112
60rRNA processing (GO:0006364)2.99416771
61positive regulation of T cell apoptotic process (GO:0070234)2.96982400
62rRNA metabolic process (GO:0016072)2.96765886
63GTP biosynthetic process (GO:0006183)2.96462497
64pyrimidine ribonucleoside catabolic process (GO:0046133)2.95085462
65hydrogen ion transmembrane transport (GO:1902600)2.93483587
66regulation of cellular respiration (GO:0043457)2.92822075
67ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91829598
68iron-sulfur cluster assembly (GO:0016226)2.89950772
69metallo-sulfur cluster assembly (GO:0031163)2.89950772
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89353524
71platelet dense granule organization (GO:0060155)2.87649429
72establishment of protein localization to membrane (GO:0090150)2.86039285
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84499780
74aldehyde catabolic process (GO:0046185)2.80424025
75drinking behavior (GO:0042756)2.80402153
76positive regulation of prostaglandin secretion (GO:0032308)2.78825695
77preassembly of GPI anchor in ER membrane (GO:0016254)2.77208165
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76672946
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75785633
80regulation of mitochondrial translation (GO:0070129)2.75670319
81response to interferon-beta (GO:0035456)2.74687419
82protein targeting (GO:0006605)2.70914653
83behavioral response to nicotine (GO:0035095)2.69085491
84ubiquinone metabolic process (GO:0006743)2.67565248
85ncRNA 3-end processing (GO:0043628)2.67351613
86substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67246593
87substrate-independent telencephalic tangential migration (GO:0021826)2.67246593
88negative regulation of appetite (GO:0032099)2.65464125
89negative regulation of response to food (GO:0032096)2.65464125
90proton transport (GO:0015992)2.64852161
91hydrogen transport (GO:0006818)2.63945966
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62974441
93cytochrome complex assembly (GO:0017004)2.58960778
94positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58914171
95aerobic respiration (GO:0009060)2.58814377
96grooming behavior (GO:0007625)2.58063630
97quinone biosynthetic process (GO:1901663)2.55228983
98positive regulation of gamma-delta T cell activation (GO:0046645)2.53473883
99negative regulation of granulocyte differentiation (GO:0030853)2.52825348
100UTP biosynthetic process (GO:0006228)2.52204861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.04157950
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.82680851
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.49299830
4EZH2_22144423_ChIP-Seq_EOC_Human3.40866165
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.27760260
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94438120
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89067019
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.79044896
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.75720583
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.74112955
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72022182
12CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.23652494
13VDR_23849224_ChIP-Seq_CD4+_Human2.23043647
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11072995
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09907136
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.04237224
17FOXP3_21729870_ChIP-Seq_TREG_Human1.91093107
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78202512
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.77915094
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74893470
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71078086
22VDR_22108803_ChIP-Seq_LS180_Human1.63325910
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62863202
24MYC_18940864_ChIP-ChIP_HL60_Human1.62219801
25XRN2_22483619_ChIP-Seq_HELA_Human1.61593342
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60521222
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.58797189
28TTF2_22483619_ChIP-Seq_HELA_Human1.51567393
29BCL6_27268052_Chip-Seq_Bcells_Human1.49663589
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49151681
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42936628
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.42851880
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42299431
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41674677
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41649100
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41133497
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39547227
38ELK1_19687146_ChIP-ChIP_HELA_Human1.37023028
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36218055
40GABP_19822575_ChIP-Seq_HepG2_Human1.36021923
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35470890
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34628391
43NANOG_20526341_ChIP-Seq_ESCs_Human1.34289334
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32940242
45MYB_26560356_Chip-Seq_TH2_Human1.32375785
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28943194
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28815093
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28388486
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27423024
50CTCF_20526341_ChIP-Seq_ESCs_Human1.26788261
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25813557
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.25599443
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25035542
54TP53_22573176_ChIP-Seq_HFKS_Human1.24236144
55NCOR_22424771_ChIP-Seq_293T_Human1.23152880
56TAF2_19829295_ChIP-Seq_ESCs_Human1.22170975
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.20980251
58P300_27268052_Chip-Seq_Bcells_Human1.19797920
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18466428
60IRF1_19129219_ChIP-ChIP_H3396_Human1.15947224
61CIITA_25753668_ChIP-Seq_RAJI_Human1.15074460
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14652654
63GATA3_26560356_Chip-Seq_TH2_Human1.14603079
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11387176
65ERA_21632823_ChIP-Seq_H3396_Human1.11366825
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10900997
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10745160
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.10571642
69P68_20966046_ChIP-Seq_HELA_Human1.10562021
70FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10460840
71MAF_26560356_Chip-Seq_TH2_Human1.10209413
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.07971947
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07964388
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06406115
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05983779
76AR_20517297_ChIP-Seq_VCAP_Human1.03313850
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.03260790
78P53_21459846_ChIP-Seq_SAOS-2_Human1.02518892
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.02306240
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00299602
81SPI1_23547873_ChIP-Seq_NB4_Human1.00041787
82SA1_27219007_Chip-Seq_Bcells_Human0.99741370
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99710131
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.99686256
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99686256
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.99557073
87ZNF274_21170338_ChIP-Seq_K562_Hela0.98847859
88FOXP1_21924763_ChIP-Seq_HESCs_Human0.98536531
89ERG_20517297_ChIP-Seq_VCAP_Human0.98244139
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95997837
91E2F1_20622854_ChIP-Seq_HELA_Human0.95390031
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.95076347
93STAT1_20625510_ChIP-Seq_HELA_Human0.95019862
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93461290
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92247546
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.92077169
97BCOR_27268052_Chip-Seq_Bcells_Human0.91093320
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90180381
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89999441
100RNF2_27304074_Chip-Seq_NSC_Mouse0.89864897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.13460117
2MP0006292_abnormal_olfactory_placode4.25191297
3MP0004147_increased_porphyrin_level3.05121868
4MP0005671_abnormal_response_to2.91912943
5MP0000685_abnormal_immune_system2.64206079
6MP0002234_abnormal_pharynx_morphology2.46939817
7MP0003646_muscle_fatigue2.32183134
8MP0001986_abnormal_taste_sensitivity2.10647392
9MP0001835_abnormal_antigen_presentation2.08087379
10MP0005387_immune_system_phenotype1.99329305
11MP0001790_abnormal_immune_system1.99329305
12MP0000678_abnormal_parathyroid_gland1.95768645
13MP0002653_abnormal_ependyma_morphology1.95560877
14MP0001800_abnormal_humoral_immune1.78284109
15MP0005075_abnormal_melanosome_morpholog1.78053968
16MP0008789_abnormal_olfactory_epithelium1.76075894
17MP0004885_abnormal_endolymph1.66608174
18MP0002837_dystrophic_cardiac_calcinosis1.62792730
19MP0004142_abnormal_muscle_tone1.52511852
20MP0003763_abnormal_thymus_physiology1.50945858
21MP0005174_abnormal_tail_pigmentation1.49194453
22MP0001188_hyperpigmentation1.49053173
23MP0008877_abnormal_DNA_methylation1.47368387
24MP0001905_abnormal_dopamine_level1.44848902
25MP0005084_abnormal_gallbladder_morpholo1.42584673
26MP0002095_abnormal_skin_pigmentation1.42020376
27MP0009785_altered_susceptibility_to1.41678641
28MP0005394_taste/olfaction_phenotype1.36746134
29MP0005499_abnormal_olfactory_system1.36746134
30MP0005423_abnormal_somatic_nervous1.36381635
31MP0001968_abnormal_touch/_nociception1.33935728
32MP0002723_abnormal_immune_serum1.32632256
33MP0006036_abnormal_mitochondrial_physio1.32391036
34MP0002138_abnormal_hepatobiliary_system1.31841470
35MP0002163_abnormal_gland_morphology1.23385351
36MP0006072_abnormal_retinal_apoptosis1.22626097
37MP0009333_abnormal_splenocyte_physiolog1.21847346
38MP0005000_abnormal_immune_tolerance1.20943346
39MP0000049_abnormal_middle_ear1.20426123
40MP0002420_abnormal_adaptive_immunity1.20135484
41MP0006276_abnormal_autonomic_nervous1.19974642
42MP0008058_abnormal_DNA_repair1.18852161
43MP0001819_abnormal_immune_cell1.17177001
44MP0002452_abnormal_antigen_presenting1.16031696
45MP0005645_abnormal_hypothalamus_physiol1.15987688
46MP0005025_abnormal_response_to1.15750062
47MP0008872_abnormal_physiological_respon1.14795958
48MP0005551_abnormal_eye_electrophysiolog1.14264122
49MP0002148_abnormal_hypersensitivity_rea1.12691618
50MP0003123_paternal_imprinting1.11815062
51MP0005389_reproductive_system_phenotype1.09471248
52MP0001293_anophthalmia1.08845414
53MP0001529_abnormal_vocalization1.08468940
54MP0005377_hearing/vestibular/ear_phenot1.04158155
55MP0003878_abnormal_ear_physiology1.04158155
56MP0001919_abnormal_reproductive_system1.02600259
57MP0001873_stomach_inflammation1.01291313
58MP0002398_abnormal_bone_marrow1.00734930
59MP0003787_abnormal_imprinting0.99125206
60MP0004145_abnormal_muscle_electrophysio0.98598147
61MP0003880_abnormal_central_pattern0.98152944
62MP0002160_abnormal_reproductive_system0.96085411
63MP0002736_abnormal_nociception_after0.95621667
64MP0000372_irregular_coat_pigmentation0.94005896
65MP0008875_abnormal_xenobiotic_pharmacok0.93399822
66MP0000716_abnormal_immune_system0.93207440
67MP0005646_abnormal_pituitary_gland0.92922703
68MP0003866_abnormal_defecation0.92681983
69MP0003436_decreased_susceptibility_to0.92381375
70MP0005670_abnormal_white_adipose0.89456974
71MP0000689_abnormal_spleen_morphology0.87692511
72MP0003786_premature_aging0.86489983
73MP0003186_abnormal_redox_activity0.86376148
74MP0009764_decreased_sensitivity_to0.84323048
75MP0002405_respiratory_system_inflammati0.82550835
76MP0000015_abnormal_ear_pigmentation0.77160681
77MP0000631_abnormal_neuroendocrine_gland0.76708238
78MP0002429_abnormal_blood_cell0.75490515
79MP0002722_abnormal_immune_system0.75187312
80MP0001324_abnormal_eye_pigmentation0.74360012
81MP0003724_increased_susceptibility_to0.72470178
82MP0000703_abnormal_thymus_morphology0.71375985
83MP0001963_abnormal_hearing_physiology0.69173447
84MP0002272_abnormal_nervous_system0.66973154
85MP0005464_abnormal_platelet_physiology0.66880717
86MP0008007_abnormal_cellular_replicative0.66387483
87MP0003567_abnormal_fetal_cardiomyocyte0.65860937
88MP0001485_abnormal_pinna_reflex0.65167658
89MP0005636_abnormal_mineral_homeostasis0.64850952
90MP0000230_abnormal_systemic_arterial0.64687575
91MP0002184_abnormal_innervation0.64640472
92MP0005195_abnormal_posterior_eye0.64515162
93MP0001119_abnormal_female_reproductive0.61939272
94MP0000026_abnormal_inner_ear0.61724653
95MP0008469_abnormal_protein_level0.61445447
96MP0001664_abnormal_digestion0.61150064
97MP0009053_abnormal_anal_canal0.60675145
98MP0002396_abnormal_hematopoietic_system0.59538357
99MP0002733_abnormal_thermal_nociception0.59305104
100MP0001764_abnormal_homeostasis0.58830914

Predicted human phenotypes

RankGene SetZ-score
1Renal Fanconi syndrome (HP:0001994)5.02706344
2Reticulocytopenia (HP:0001896)4.74660760
3Acute necrotizing encephalopathy (HP:0006965)4.55858647
4Abnormality of cells of the erythroid lineage (HP:0012130)4.54279177
5Mitochondrial inheritance (HP:0001427)4.37529896
6Abnormal mitochondria in muscle tissue (HP:0008316)4.26535784
7Increased hepatocellular lipid droplets (HP:0006565)3.92127929
8Increased CSF lactate (HP:0002490)3.90681876
9Abnormal number of erythroid precursors (HP:0012131)3.75215128
10Acute encephalopathy (HP:0006846)3.73117356
11Progressive macrocephaly (HP:0004481)3.68470466
12Macrocytic anemia (HP:0001972)3.68322759
13Hepatocellular necrosis (HP:0001404)3.62009152
14Lipid accumulation in hepatocytes (HP:0006561)3.61126891
15Increased intramyocellular lipid droplets (HP:0012240)3.52862403
16Pallor (HP:0000980)3.35730838
173-Methylglutaconic aciduria (HP:0003535)3.29830485
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.26434101
19Hepatic necrosis (HP:0002605)3.21132320
20Abnormality of renal resorption (HP:0011038)3.12764966
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01749630
22Increased muscle lipid content (HP:0009058)3.00481826
23Increased IgM level (HP:0003496)2.97724811
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84680929
25Abnormal drinking behavior (HP:0030082)2.81956479
26Polydipsia (HP:0001959)2.81956479
27Abolished electroretinogram (ERG) (HP:0000550)2.81861846
28Abnormality of B cell number (HP:0010975)2.81589034
29Cerebral edema (HP:0002181)2.80099727
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78539218
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78539218
32Generalized aminoaciduria (HP:0002909)2.76084223
33Exertional dyspnea (HP:0002875)2.75433882
34Absent thumb (HP:0009777)2.72491832
35Molar tooth sign on MRI (HP:0002419)2.72288342
36Abnormality of midbrain morphology (HP:0002418)2.72288342
37Failure to thrive in infancy (HP:0001531)2.70752833
38Elevated erythrocyte sedimentation rate (HP:0003565)2.68779597
39Abnormality of urine glucose concentration (HP:0011016)2.68101468
40Glycosuria (HP:0003076)2.68101468
41Increased serum lactate (HP:0002151)2.48936065
42Congenital stationary night blindness (HP:0007642)2.48661169
43Abnormal rod and cone electroretinograms (HP:0008323)2.46084219
44Pancreatic fibrosis (HP:0100732)2.45848115
45Optic disc pallor (HP:0000543)2.44446703
46Septo-optic dysplasia (HP:0100842)2.42202647
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37338156
48Respiratory difficulties (HP:0002880)2.33224624
49Pancreatic cysts (HP:0001737)2.32144818
50Lactic acidosis (HP:0003128)2.27800459
51IgG deficiency (HP:0004315)2.27204353
52Asplenia (HP:0001746)2.22767458
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.17537788
54Abnormality of the costochondral junction (HP:0000919)2.12996062
55B lymphocytopenia (HP:0010976)2.12030381
56Polyuria (HP:0000103)2.06021938
57Exercise intolerance (HP:0003546)2.05163987
58Hypoplasia of the radius (HP:0002984)2.01354661
59Abnormality of DNA repair (HP:0003254)1.99459404
60Dynein arm defect of respiratory motile cilia (HP:0012255)1.99058161
61Absent/shortened dynein arms (HP:0200106)1.99058161
62Abnormal delayed hypersensitivity skin test (HP:0002963)1.97863019
6311 pairs of ribs (HP:0000878)1.97528083
64Type 2 muscle fiber atrophy (HP:0003554)1.96195461
65Panhypogammaglobulinemia (HP:0003139)1.93204399
66Aplastic anemia (HP:0001915)1.92433522
67Hyperphosphaturia (HP:0003109)1.91593708
68True hermaphroditism (HP:0010459)1.90077531
69Respiratory failure (HP:0002878)1.89011866
70Hypophosphatemic rickets (HP:0004912)1.86158425
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83584470
72Abnormality of alanine metabolism (HP:0010916)1.83584470
73Hyperalaninemia (HP:0003348)1.83584470
74Triphalangeal thumb (HP:0001199)1.83423739
75Severe combined immunodeficiency (HP:0004430)1.83165981
76Stenosis of the external auditory canal (HP:0000402)1.82163496
77Muscle fiber atrophy (HP:0100295)1.81517121
78Male infertility (HP:0003251)1.79330399
79Tetany (HP:0001281)1.78595136
80Pancytopenia (HP:0001876)1.77157737
81Encephalitis (HP:0002383)1.75468447
82Lethargy (HP:0001254)1.73334247
83Absent septum pellucidum (HP:0001331)1.73308864
84Abnormal hemoglobin (HP:0011902)1.73206959
85Stomatitis (HP:0010280)1.70856841
86Constricted visual fields (HP:0001133)1.70408513
87Type II lissencephaly (HP:0007260)1.68983203
88Abnormal urine output (HP:0012590)1.68875064
89Anencephaly (HP:0002323)1.67296215
90Optic nerve hypoplasia (HP:0000609)1.67145589
91Abnormal respiratory epithelium morphology (HP:0012253)1.66042861
92Abnormal respiratory motile cilium morphology (HP:0005938)1.66042861
93Nephronophthisis (HP:0000090)1.64977435
94Depressed nasal ridge (HP:0000457)1.62639182
95Supernumerary spleens (HP:0009799)1.62420292
96Sclerocornea (HP:0000647)1.62194842
97Hyperglycinemia (HP:0002154)1.62004879
98Forearm undergrowth (HP:0009821)1.60872254
99Partial duplication of thumb phalanx (HP:0009944)1.60203202
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59787367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.82969376
2MUSK3.62767559
3MAP4K23.13818227
4KDR3.05257309
5VRK22.86563611
6TLK12.83743061
7GRK12.69198334
8MAP4K12.61041659
9TAOK32.53937664
10CDK192.53401918
11NME22.15823780
12KIT2.13642858
13TIE12.13437237
14BCKDK2.12968021
15MAP3K111.94045106
16IKBKE1.93168136
17SCYL21.86214464
18WNK41.83710771
19FLT31.81550586
20ADRBK21.81239588
21MAP3K121.54066991
22GRK61.43758675
23BTK1.41274572
24ZAK1.38761842
25IKBKB1.37793656
26TESK21.37525785
27NUAK11.37190457
28SYK1.35396502
29PIK3CA1.33014378
30STK161.32351104
31PRKG21.28607813
32CSF1R1.28604823
33VRK11.27147192
34PASK1.19677785
35BLK1.14488211
36ITK1.10077620
37RPS6KB21.05923897
38DYRK21.04576753
39FES0.95692770
40CDC70.89824871
41TEC0.88494255
42LRRK20.87751377
43PRKCH0.85944009
44TBK10.85561920
45PRKCQ0.83155174
46DAPK30.82616739
47CSK0.77404447
48BMPR1B0.73821946
49NME10.73208507
50ILK0.71016894
51RPS6KA60.70358394
52INSRR0.68968637
53CAMK10.67859620
54LCK0.67057459
55ZAP700.66828949
56MYLK0.65242506
57LYN0.63195602
58AURKB0.63102181
59NEK20.62114124
60CSNK1G30.60554629
61PIM10.60145257
62PINK10.59589655
63OXSR10.58110749
64MATK0.57881375
65ADRBK10.57507409
66MAP2K20.55220969
67AURKA0.54963204
68RPS6KA50.54617293
69RPS6KC10.54091631
70RPS6KL10.54091631
71PRKCD0.52981880
72DAPK10.51868850
73TGFBR10.51568027
74CAMKK10.50301855
75MAPKAPK30.49046975
76CSNK2A20.48619769
77ABL20.47750518
78PRKACA0.47355761
79NEK10.47305119
80PRKCG0.46552848
81CAMKK20.45930153
82TAOK20.45703939
83BMPR20.44568663
84CSNK1G20.44293376
85JAK30.43960493
86LIMK10.43105608
87CSNK2A10.39153598
88CHEK20.38643863
89HCK0.38619625
90PRKCA0.38126389
91WNK30.37942385
92OBSCN0.36860315
93PRKCI0.34996903
94CDK80.34984772
95MAPK130.34049314
96PKN10.32435570
97FRK0.32139500
98CSNK1G10.32036683
99MAPKAPK50.31634247
100GRK70.31422216

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.57012167
2Oxidative phosphorylation_Homo sapiens_hsa001904.18364519
3Parkinsons disease_Homo sapiens_hsa050123.55379217
4Asthma_Homo sapiens_hsa053103.02169821
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.66002204
6Alzheimers disease_Homo sapiens_hsa050102.52768774
7Huntingtons disease_Homo sapiens_hsa050162.49473204
8Allograft rejection_Homo sapiens_hsa053302.45122900
9Primary immunodeficiency_Homo sapiens_hsa053402.41338061
10Graft-versus-host disease_Homo sapiens_hsa053322.39169634
11Autoimmune thyroid disease_Homo sapiens_hsa053202.31962828
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29309198
13Cardiac muscle contraction_Homo sapiens_hsa042602.26826516
14Proteasome_Homo sapiens_hsa030502.05294663
15RNA polymerase_Homo sapiens_hsa030202.01976757
16One carbon pool by folate_Homo sapiens_hsa006701.91461607
17Type I diabetes mellitus_Homo sapiens_hsa049401.84235057
18Homologous recombination_Homo sapiens_hsa034401.78193866
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75400146
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74897250
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69240723
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69222790
23Antigen processing and presentation_Homo sapiens_hsa046121.48729892
24Linoleic acid metabolism_Homo sapiens_hsa005911.48277978
25Pyrimidine metabolism_Homo sapiens_hsa002401.35232486
26Fanconi anemia pathway_Homo sapiens_hsa034601.22375537
27RNA degradation_Homo sapiens_hsa030181.20935576
28Basal transcription factors_Homo sapiens_hsa030221.18632316
29Protein export_Homo sapiens_hsa030601.16408663
30Nucleotide excision repair_Homo sapiens_hsa034201.13935751
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10324572
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08822565
33DNA replication_Homo sapiens_hsa030301.00071669
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99705820
35Hematopoietic cell lineage_Homo sapiens_hsa046400.96322178
36Rheumatoid arthritis_Homo sapiens_hsa053230.91060753
37Phototransduction_Homo sapiens_hsa047440.89542759
38Sulfur relay system_Homo sapiens_hsa041220.86523297
39Base excision repair_Homo sapiens_hsa034100.86307870
40Nitrogen metabolism_Homo sapiens_hsa009100.85140767
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82569779
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81626241
43Arachidonic acid metabolism_Homo sapiens_hsa005900.80673083
44Purine metabolism_Homo sapiens_hsa002300.77145443
45Viral myocarditis_Homo sapiens_hsa054160.76782232
46Olfactory transduction_Homo sapiens_hsa047400.76330654
47Fat digestion and absorption_Homo sapiens_hsa049750.74195289
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73318624
49Mismatch repair_Homo sapiens_hsa034300.71883015
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70977554
51Staphylococcus aureus infection_Homo sapiens_hsa051500.66120170
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65884925
53Butanoate metabolism_Homo sapiens_hsa006500.64145532
54Spliceosome_Homo sapiens_hsa030400.63753594
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63155837
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61740774
57Metabolic pathways_Homo sapiens_hsa011000.56826745
58Ether lipid metabolism_Homo sapiens_hsa005650.55814962
59Herpes simplex infection_Homo sapiens_hsa051680.55184499
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54874151
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54838306
62Systemic lupus erythematosus_Homo sapiens_hsa053220.53458485
63Tryptophan metabolism_Homo sapiens_hsa003800.52641937
64Vitamin B6 metabolism_Homo sapiens_hsa007500.52537212
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51791318
66RNA transport_Homo sapiens_hsa030130.50839539
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.49730640
68Peroxisome_Homo sapiens_hsa041460.46449737
69Chemical carcinogenesis_Homo sapiens_hsa052040.44889126
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.43449706
71Leishmaniasis_Homo sapiens_hsa051400.42773120
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41944983
73Retinol metabolism_Homo sapiens_hsa008300.40374895
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40318614
75Sulfur metabolism_Homo sapiens_hsa009200.40301004
76T cell receptor signaling pathway_Homo sapiens_hsa046600.40281078
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39572123
78Regulation of autophagy_Homo sapiens_hsa041400.38122879
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.36570359
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34283829
81Epstein-Barr virus infection_Homo sapiens_hsa051690.33412887
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33086673
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32506655
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.32394004
85Salivary secretion_Homo sapiens_hsa049700.29769617
86Malaria_Homo sapiens_hsa051440.29708172
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.29356695
88Taste transduction_Homo sapiens_hsa047420.29254016
89African trypanosomiasis_Homo sapiens_hsa051430.28405749
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25457213
91Propanoate metabolism_Homo sapiens_hsa006400.24713172
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.22534999
93Caffeine metabolism_Homo sapiens_hsa002320.19559350
94Tuberculosis_Homo sapiens_hsa051520.19503038
95Glycerolipid metabolism_Homo sapiens_hsa005610.19119755
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18983853
97Pancreatic secretion_Homo sapiens_hsa049720.18467575
98Collecting duct acid secretion_Homo sapiens_hsa049660.18041380
99Tyrosine metabolism_Homo sapiens_hsa003500.17106559
100Folate biosynthesis_Homo sapiens_hsa007900.15271771

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