RPS2P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.55729312
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.86410369
3DNA deamination (GO:0045006)6.68569247
4viral transcription (GO:0019083)6.59168294
5ribosomal small subunit biogenesis (GO:0042274)6.56030066
6translational termination (GO:0006415)6.24668716
7cytidine deamination (GO:0009972)6.17416155
8cytidine metabolic process (GO:0046087)6.17416155
9cytidine catabolic process (GO:0006216)6.17416155
10translational elongation (GO:0006414)5.54285125
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.28657099
12pyrimidine ribonucleoside catabolic process (GO:0046133)5.27984259
13cotranslational protein targeting to membrane (GO:0006613)5.17725325
14protein targeting to ER (GO:0045047)5.15617316
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.92788025
16protein localization to endoplasmic reticulum (GO:0070972)4.91004886
17cellular protein complex disassembly (GO:0043624)4.78864084
18viral life cycle (GO:0019058)4.72418637
19maturation of SSU-rRNA (GO:0030490)4.55846603
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.39220942
21ATP synthesis coupled proton transport (GO:0015986)4.22871036
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.22871036
23ncRNA 3-end processing (GO:0043628)4.22773074
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04015577
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97633187
26translational initiation (GO:0006413)3.93253818
27protein complex disassembly (GO:0043241)3.92360520
28regulation of gamma-delta T cell differentiation (GO:0045586)3.73707393
29macromolecular complex disassembly (GO:0032984)3.73526320
30regulation of regulatory T cell differentiation (GO:0045589)3.69933938
31positive regulation of gamma-delta T cell activation (GO:0046645)3.66808917
32positive thymic T cell selection (GO:0045059)3.56604624
33cytolysis (GO:0019835)3.53260983
34respiratory electron transport chain (GO:0022904)3.48263347
35electron transport chain (GO:0022900)3.46130014
36positive T cell selection (GO:0043368)3.44342793
37protein targeting to membrane (GO:0006612)3.44117491
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40603594
39sequestering of actin monomers (GO:0042989)3.40286952
40positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.32880978
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31287680
42positive regulation of natural killer cell mediated immunity (GO:0002717)3.30527745
43behavioral response to nicotine (GO:0035095)3.29830452
44protein neddylation (GO:0045116)3.29725660
45T cell migration (GO:0072678)3.24993424
46ribosomal large subunit biogenesis (GO:0042273)3.22848976
47translation (GO:0006412)3.18338669
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16800569
49regulation of natural killer cell mediated immunity (GO:0002715)3.16800569
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15460443
51actin nucleation (GO:0045010)3.13251403
52regulation of activation of Janus kinase activity (GO:0010533)3.12729175
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.10348196
54positive regulation of B cell differentiation (GO:0045579)3.07620600
55negative regulation of T cell apoptotic process (GO:0070233)3.07284067
56nuclear-transcribed mRNA catabolic process (GO:0000956)3.03158574
57ribonucleoprotein complex biogenesis (GO:0022613)3.01033860
58response to pheromone (GO:0019236)3.00886109
59regulation of B cell receptor signaling pathway (GO:0050855)3.00426675
60protein complex biogenesis (GO:0070271)2.97563932
61negative T cell selection (GO:0043383)2.97222473
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93892636
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92379030
64regulation of leukocyte mediated cytotoxicity (GO:0001910)2.92200136
65regulation of gamma-delta T cell activation (GO:0046643)2.91100833
66positive regulation of T cell apoptotic process (GO:0070234)2.89468967
67positive regulation of calcium-mediated signaling (GO:0050850)2.88393607
68positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.87784161
69iron-sulfur cluster assembly (GO:0016226)2.87271470
70metallo-sulfur cluster assembly (GO:0031163)2.87271470
71pyrimidine nucleoside catabolic process (GO:0046135)2.86954044
72mRNA catabolic process (GO:0006402)2.85653699
73negative regulation of viral genome replication (GO:0045071)2.82834574
74cellular component biogenesis (GO:0044085)2.82736059
75thymic T cell selection (GO:0045061)2.79974670
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76919087
77GTP biosynthetic process (GO:0006183)2.75969498
78response to interferon-beta (GO:0035456)2.73880541
79positive regulation of cell killing (GO:0031343)2.73862024
80regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.67436778
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.65556048
82NADH dehydrogenase complex assembly (GO:0010257)2.65556048
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65556048
84positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.65535917
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64763244
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63219693
87mitochondrial respiratory chain complex assembly (GO:0033108)2.63218338
88positive regulation of defense response to virus by host (GO:0002230)2.62317407
89ATP biosynthetic process (GO:0006754)2.61224427
90axoneme assembly (GO:0035082)2.59209801
91regulation of cell killing (GO:0031341)2.59132337
92cellular response to interleukin-15 (GO:0071350)2.58398440
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57779608
94regulation of B cell differentiation (GO:0045577)2.57704941
95purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56340782
96RNA catabolic process (GO:0006401)2.55371785
97negative regulation by host of viral transcription (GO:0043922)2.50612345
98GPI anchor metabolic process (GO:0006505)2.49000339
99transmission of nerve impulse (GO:0019226)2.48485470
100regulation of T cell apoptotic process (GO:0070232)2.47157385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93137319
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06151940
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99482325
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02387534
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.82337733
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.71193909
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.49742212
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42600399
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34380545
10VDR_22108803_ChIP-Seq_LS180_Human2.28903611
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13063746
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03559089
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98632816
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96228223
15ZNF274_21170338_ChIP-Seq_K562_Hela1.89470409
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.88677922
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.84453233
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78854950
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78047280
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68676695
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67221391
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.66449402
23BCL6_27268052_Chip-Seq_Bcells_Human1.60808743
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57150584
25NANOG_20526341_ChIP-Seq_ESCs_Human1.56562806
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.55282012
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55034761
28VDR_23849224_ChIP-Seq_CD4+_Human1.54936139
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54300849
30MYB_26560356_Chip-Seq_TH2_Human1.53534914
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50213288
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49918633
33RUNX_20019798_ChIP-Seq_JUKART_Human1.49168879
34TAF2_19829295_ChIP-Seq_ESCs_Human1.47790665
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43358985
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41034875
37MYC_18940864_ChIP-ChIP_HL60_Human1.39238156
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38412932
39TP53_22573176_ChIP-Seq_HFKS_Human1.36636227
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35819377
41CTCF_20526341_ChIP-Seq_ESCs_Human1.32820218
42EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32399076
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.32393310
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.30975901
45NCOR_22424771_ChIP-Seq_293T_Human1.27942299
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27494960
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.27291281
48ERA_21632823_ChIP-Seq_H3396_Human1.26899721
49UTX_26944678_Chip-Seq_JUKART_Human1.26222083
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26176077
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25660199
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.23574341
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22109602
54AR_20517297_ChIP-Seq_VCAP_Human1.21963589
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21291875
56GATA3_27048872_Chip-Seq_THYMUS_Human1.20047121
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.17724125
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14964031
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.14964031
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13612274
61SA1_27219007_Chip-Seq_Bcells_Human1.13264393
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.12800623
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12279667
64IGF1R_20145208_ChIP-Seq_DFB_Human1.10629975
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.09578406
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.09174140
67P53_21459846_ChIP-Seq_SAOS-2_Human1.08870130
68GATA3_26560356_Chip-Seq_TH2_Human1.08679360
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08365443
70P300_27268052_Chip-Seq_Bcells_Human1.08073103
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06067918
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.05663521
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05540404
74CTCF_27219007_Chip-Seq_Bcells_Human1.05294438
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04667800
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04261679
77E2F1_20622854_ChIP-Seq_HELA_Human1.04158950
78MYC_19829295_ChIP-Seq_ESCs_Human1.02328075
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01991353
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00661694
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00556080
82RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00373738
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00355749
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00262613
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99098051
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98322574
87FOXP3_21729870_ChIP-Seq_TREG_Human0.98090251
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97932107
89HTT_18923047_ChIP-ChIP_STHdh_Human0.97706880
90BCOR_27268052_Chip-Seq_Bcells_Human0.97177990
91MAF_26560356_Chip-Seq_TH2_Human0.96370849
92STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96323568
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96210583
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94419260
95SCL_19346495_ChIP-Seq_HPC-7_Human0.93486546
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92338173
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91940198
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91764980
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.91410646
100RAC3_21632823_ChIP-Seq_H3396_Human0.91349775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.70213023
2MP0009379_abnormal_foot_pigmentation3.93358087
3MP0006292_abnormal_olfactory_placode2.49098003
4MP0002163_abnormal_gland_morphology2.46797266
5MP0009785_altered_susceptibility_to2.43721835
6MP0001873_stomach_inflammation2.29927951
7MP0005377_hearing/vestibular/ear_phenot2.28305222
8MP0003878_abnormal_ear_physiology2.28305222
9MP0006082_CNS_inflammation2.20186469
10MP0001835_abnormal_antigen_presentation2.09618708
11MP0003763_abnormal_thymus_physiology2.04136121
12MP0005645_abnormal_hypothalamus_physiol2.01720140
13MP0005646_abnormal_pituitary_gland2.01106252
14MP0004147_increased_porphyrin_level1.97535054
15MP0009333_abnormal_splenocyte_physiolog1.94201078
16MP0003879_abnormal_hair_cell1.77187908
17MP0001968_abnormal_touch/_nociception1.73072451
18MP0001800_abnormal_humoral_immune1.67065756
19MP0001905_abnormal_dopamine_level1.65973761
20MP0005551_abnormal_eye_electrophysiolog1.64965723
21MP0004885_abnormal_endolymph1.62510462
22MP0003646_muscle_fatigue1.61889285
23MP0002102_abnormal_ear_morphology1.60621688
24MP0005379_endocrine/exocrine_gland_phen1.56662937
25MP0002736_abnormal_nociception_after1.56580819
26MP0005000_abnormal_immune_tolerance1.55038642
27MP0003866_abnormal_defecation1.54373070
28MP0005025_abnormal_response_to1.52909609
29MP0002138_abnormal_hepatobiliary_system1.52717618
30MP0002420_abnormal_adaptive_immunity1.50572977
31MP0002723_abnormal_immune_serum1.47921024
32MP0008875_abnormal_xenobiotic_pharmacok1.47233180
33MP0002638_abnormal_pupillary_reflex1.47145389
34MP0001819_abnormal_immune_cell1.44701415
35MP0008872_abnormal_physiological_respon1.44486822
36MP0001485_abnormal_pinna_reflex1.44291845
37MP0005075_abnormal_melanosome_morpholog1.39576927
38MP0002148_abnormal_hypersensitivity_rea1.39349665
39MP0002837_dystrophic_cardiac_calcinosis1.36690979
40MP0002933_joint_inflammation1.34416194
41MP0002653_abnormal_ependyma_morphology1.32766994
42MP0002822_catalepsy1.30381751
43MP0006276_abnormal_autonomic_nervous1.29328758
44MP0000372_irregular_coat_pigmentation1.26732927
45MP0004145_abnormal_muscle_electrophysio1.22501424
46MP0000716_abnormal_immune_system1.21622206
47MP0000685_abnormal_immune_system1.20090664
48MP0002398_abnormal_bone_marrow1.20055053
49MP0001986_abnormal_taste_sensitivity1.18639041
50MP0005389_reproductive_system_phenotype1.18555666
51MP0002166_altered_tumor_susceptibility1.17658999
52MP0002160_abnormal_reproductive_system1.17350125
53MP0004742_abnormal_vestibular_system1.16431243
54MP0002095_abnormal_skin_pigmentation1.15439777
55MP0002452_abnormal_antigen_presenting1.14859818
56MP0002405_respiratory_system_inflammati1.13871742
57MP0002733_abnormal_thermal_nociception1.13832140
58MP0002735_abnormal_chemical_nociception1.13243084
59MP0004510_myositis1.11452171
60MP0005410_abnormal_fertilization1.09803933
61MP0002876_abnormal_thyroid_physiology1.08134669
62MP0002234_abnormal_pharynx_morphology1.06490856
63MP0000678_abnormal_parathyroid_gland1.06394539
64MP0005387_immune_system_phenotype1.04559777
65MP0001790_abnormal_immune_system1.04559777
66MP0000703_abnormal_thymus_morphology1.03189110
67MP0008877_abnormal_DNA_methylation1.02137435
68MP0001970_abnormal_pain_threshold1.01902531
69MP0004142_abnormal_muscle_tone1.01761757
70MP0000689_abnormal_spleen_morphology1.01573805
71MP0000631_abnormal_neuroendocrine_gland1.00767121
72MP0006072_abnormal_retinal_apoptosis0.99942180
73MP0000026_abnormal_inner_ear0.99905246
74MP0001963_abnormal_hearing_physiology0.99677395
75MP0010155_abnormal_intestine_physiology0.98728197
76MP0002277_abnormal_respiratory_mucosa0.98310121
77MP0001919_abnormal_reproductive_system0.96224879
78MP0008995_early_reproductive_senescence0.95970621
79MP0002722_abnormal_immune_system0.95664911
80MP0003787_abnormal_imprinting0.93998037
81MP0008789_abnormal_olfactory_epithelium0.92141746
82MP0001529_abnormal_vocalization0.91993748
83MP0002429_abnormal_blood_cell0.90701288
84MP0001764_abnormal_homeostasis0.89486448
85MP0001845_abnormal_inflammatory_respons0.89220287
86MP0002006_tumorigenesis0.86966256
87MP0005084_abnormal_gallbladder_morpholo0.85934073
88MP0008469_abnormal_protein_level0.84874596
89MP0009745_abnormal_behavioral_response0.82685593
90MP0000049_abnormal_middle_ear0.82104376
91MP0002272_abnormal_nervous_system0.81571990
92MP0002419_abnormal_innate_immunity0.77799340
93MP0001663_abnormal_digestive_system0.76740196
94MP0001664_abnormal_digestion0.76150084
95MP0003436_decreased_susceptibility_to0.75869961
96MP0002693_abnormal_pancreas_physiology0.74387105
97MP0005253_abnormal_eye_physiology0.73621414
98MP0004130_abnormal_muscle_cell0.73578102
99MP0009764_decreased_sensitivity_to0.72248094
100MP0005636_abnormal_mineral_homeostasis0.69946943

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.42297189
2Aplastic anemia (HP:0001915)4.38123612
3Attenuation of retinal blood vessels (HP:0007843)4.32113981
4Abnormal rod and cone electroretinograms (HP:0008323)4.16970170
5Constricted visual fields (HP:0001133)3.76027690
6Acute necrotizing encephalopathy (HP:0006965)3.73380175
7Mitochondrial inheritance (HP:0001427)3.70703777
8Abnormal mitochondria in muscle tissue (HP:0008316)3.60586692
9Reticulocytopenia (HP:0001896)3.50092365
10Abnormality of cells of the erythroid lineage (HP:0012130)3.41020595
11Abnormality of macular pigmentation (HP:0008002)3.37991083
12IgG deficiency (HP:0004315)3.35868532
13T lymphocytopenia (HP:0005403)3.31051923
14Increased intramyocellular lipid droplets (HP:0012240)3.25644536
15Pancreatic cysts (HP:0001737)3.22277882
16Elevated erythrocyte sedimentation rate (HP:0003565)3.19826510
17Progressive macrocephaly (HP:0004481)3.09111439
18Acute encephalopathy (HP:0006846)3.08794195
19Molar tooth sign on MRI (HP:0002419)3.07913224
20Abnormality of midbrain morphology (HP:0002418)3.07913224
21Increased hepatocellular lipid droplets (HP:0006565)3.07293282
22Pancreatic fibrosis (HP:0100732)3.03131313
23Abnormal number of erythroid precursors (HP:0012131)3.01582363
24Renal Fanconi syndrome (HP:0001994)3.00989953
25Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93054808
26Optic disc pallor (HP:0000543)2.92947655
27Increased CSF lactate (HP:0002490)2.92532078
28Congenital stationary night blindness (HP:0007642)2.91275647
29Abnormality of T cell number (HP:0011839)2.88938019
30Severe combined immunodeficiency (HP:0004430)2.84471760
31Decreased central vision (HP:0007663)2.80036434
32True hermaphroditism (HP:0010459)2.78898861
33Increased muscle lipid content (HP:0009058)2.76781478
34Lipid accumulation in hepatocytes (HP:0006561)2.76428188
35Macrocytic anemia (HP:0001972)2.73295591
36Hepatocellular necrosis (HP:0001404)2.73044888
373-Methylglutaconic aciduria (HP:0003535)2.71462132
38Pallor (HP:0000980)2.66148743
39Cerebral edema (HP:0002181)2.65538922
40Asplenia (HP:0001746)2.64302555
41Abnormality of T cells (HP:0002843)2.59976838
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.58139925
43Absent/shortened dynein arms (HP:0200106)2.58139925
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.53907692
45Abolished electroretinogram (ERG) (HP:0000550)2.53756054
46Stomatitis (HP:0010280)2.52433662
47B lymphocytopenia (HP:0010976)2.50793067
48Hypoproteinemia (HP:0003075)2.46217052
49Thyroiditis (HP:0100646)2.39321363
50Abnormality of B cell number (HP:0010975)2.32923165
51Exertional dyspnea (HP:0002875)2.29361098
52Severe visual impairment (HP:0001141)2.27829394
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24842821
54Pendular nystagmus (HP:0012043)2.23101390
55Cystic liver disease (HP:0006706)2.21805563
56Hepatic necrosis (HP:0002605)2.20664937
57Increased IgM level (HP:0003496)2.18357615
58Abnormal respiratory motile cilium physiology (HP:0012261)2.16603962
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13331898
60Absent thumb (HP:0009777)2.12184263
61Type II lissencephaly (HP:0007260)2.07506968
62Hypoplasia of the uterus (HP:0000013)2.06623625
63Combined immunodeficiency (HP:0005387)2.06406629
64Pancytopenia (HP:0001876)2.01958416
65Thrombocytosis (HP:0001894)1.99586001
66Aplasia/hypoplasia of the uterus (HP:0008684)1.99095358
67Abnormal respiratory epithelium morphology (HP:0012253)1.98012431
68Abnormal respiratory motile cilium morphology (HP:0005938)1.98012431
69Sclerocornea (HP:0000647)1.97848296
70Abnormal ciliary motility (HP:0012262)1.97845023
71Abnormality of renal resorption (HP:0011038)1.93364245
72Bony spicule pigmentary retinopathy (HP:0007737)1.87087325
73Autoimmune hemolytic anemia (HP:0001890)1.86382123
74Lactic acidosis (HP:0003128)1.85848615
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85498190
76Increased corneal curvature (HP:0100692)1.84390987
77Keratoconus (HP:0000563)1.84390987
78Encephalitis (HP:0002383)1.83814371
79Thyroid-stimulating hormone excess (HP:0002925)1.82150819
80Abnormality of eosinophils (HP:0001879)1.81199293
81Nephronophthisis (HP:0000090)1.77928206
82Abnormality of DNA repair (HP:0003254)1.75589479
83Chronic obstructive pulmonary disease (HP:0006510)1.73746669
84Obstructive lung disease (HP:0006536)1.73746669
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72227654
86Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71996776
87Ketosis (HP:0001946)1.71813072
88Respiratory difficulties (HP:0002880)1.70563070
89Anencephaly (HP:0002323)1.70365416
90Increased serum lactate (HP:0002151)1.70199642
91Abnormality of the phalanges of the 5th finger (HP:0004213)1.70152289
92IgM deficiency (HP:0002850)1.69878732
93Medial flaring of the eyebrow (HP:0010747)1.69651933
94Polydipsia (HP:0001959)1.67440590
95Abnormal drinking behavior (HP:0030082)1.67440590
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67370669
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67370669
98Recurrent otitis media (HP:0000403)1.66551638
99Abnormality of the prostate (HP:0008775)1.65608657
100Stenosis of the external auditory canal (HP:0000402)1.64300693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.44975760
2BCKDK3.55962889
3TESK23.37620944
4TXK3.23637856
5KIT3.15280201
6ZAK2.93527026
7TAOK32.87471534
8MAP4K12.85616473
9MAP4K22.77482054
10CDK192.54995616
11TEC2.49639233
12ADRBK22.37305412
13FES2.04269035
14VRK22.02982023
15ITK1.99355060
16TLK11.91565205
17GRK11.74397832
18SYK1.63427461
19WNK41.60834975
20STK161.56995859
21TIE11.55544877
22VRK11.50986102
23BTK1.50799670
24LIMK11.46755570
25MUSK1.41750021
26NUAK11.37949743
27PRKCQ1.35824123
28FRK1.32437389
29IKBKB1.17448224
30JAK31.14713416
31GRK61.13704524
32GRK71.11827134
33DYRK21.11419546
34ADRBK11.06705637
35CSK1.03617726
36LCK1.03176301
37TESK11.01908199
38MAP3K111.01449007
39PASK0.96820423
40MAP3K120.96388938
41DAPK20.95058078
42CSF1R0.90432822
43IKBKE0.87395530
44LRRK20.83265374
45LYN0.82658870
46DAPK30.78325311
47INSRR0.78273944
48TBK10.76203772
49TAF10.75673928
50MAP3K50.75445100
51DAPK10.73598300
52TNK20.72916066
53RPS6KA50.69280711
54OBSCN0.65205201
55PIM10.63965576
56WNK30.62043415
57TYRO30.61851531
58PIK3CA0.61340429
59MAP3K40.60774138
60SCYL20.59889279
61MAP2K70.56980934
62STK390.56923766
63NEK20.56166418
64CSNK1G30.55982491
65PIM20.54754601
66PRKACA0.54107543
67MAPK130.53148191
68ABL20.51580748
69RPS6KA60.50884066
70OXSR10.50667669
71SIK20.50287069
72PRKCA0.49801652
73PRKCH0.49739193
74NTRK20.48704413
75GRK50.46583780
76CHEK20.45850783
77AURKA0.45633909
78EPHA40.43929778
79ZAP700.42729339
80NME20.41725285
81CSNK1G10.41431961
82FYN0.39943972
83INSR0.39697551
84CSNK2A20.38767902
85BMPR1B0.37050854
86PRKG20.36162388
87PRKCG0.35743054
88PINK10.35611272
89PRKCI0.34851634
90PKN10.34774958
91PRKCD0.34464588
92CAMK10.34321596
93RPS6KC10.34309346
94RPS6KL10.34309346
95CAMK2A0.33962401
96MATK0.33795424
97PIK3CG0.33617937
98MAPK150.32596730
99HCK0.32363545
100ROCK10.31080021

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.64739081
2Primary immunodeficiency_Homo sapiens_hsa053404.67512145
3Oxidative phosphorylation_Homo sapiens_hsa001903.91081429
4Parkinsons disease_Homo sapiens_hsa050123.19750387
5Phototransduction_Homo sapiens_hsa047442.43685146
6Graft-versus-host disease_Homo sapiens_hsa053322.32199893
7Alzheimers disease_Homo sapiens_hsa050102.17142067
8Proteasome_Homo sapiens_hsa030502.16069565
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10104631
10Cardiac muscle contraction_Homo sapiens_hsa042602.09688745
11Autoimmune thyroid disease_Homo sapiens_hsa053202.01485967
12Allograft rejection_Homo sapiens_hsa053302.01449220
13Hematopoietic cell lineage_Homo sapiens_hsa046402.00614857
14Huntingtons disease_Homo sapiens_hsa050161.98977837
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98604538
16Antigen processing and presentation_Homo sapiens_hsa046121.94851965
17RNA polymerase_Homo sapiens_hsa030201.83733477
18Linoleic acid metabolism_Homo sapiens_hsa005911.80191453
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72993376
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64376000
21Nitrogen metabolism_Homo sapiens_hsa009101.61327958
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57348843
23Type I diabetes mellitus_Homo sapiens_hsa049401.48905443
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43439961
25T cell receptor signaling pathway_Homo sapiens_hsa046601.40601154
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.39309633
27Olfactory transduction_Homo sapiens_hsa047401.37086332
28Asthma_Homo sapiens_hsa053101.23823948
29Sulfur metabolism_Homo sapiens_hsa009201.15483741
30Peroxisome_Homo sapiens_hsa041461.14841825
31Arachidonic acid metabolism_Homo sapiens_hsa005901.02966719
32Pyrimidine metabolism_Homo sapiens_hsa002401.02114262
33Nicotine addiction_Homo sapiens_hsa050331.00638027
34Rheumatoid arthritis_Homo sapiens_hsa053230.99968091
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98615469
36Sulfur relay system_Homo sapiens_hsa041220.98575799
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.98053031
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.97608796
39Caffeine metabolism_Homo sapiens_hsa002320.96587244
40Ether lipid metabolism_Homo sapiens_hsa005650.95128062
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93774204
42Malaria_Homo sapiens_hsa051440.86389759
43RNA degradation_Homo sapiens_hsa030180.86183844
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85886588
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83225549
46Basal transcription factors_Homo sapiens_hsa030220.82563925
47Retinol metabolism_Homo sapiens_hsa008300.79675371
48Chemical carcinogenesis_Homo sapiens_hsa052040.79287026
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78376349
50Purine metabolism_Homo sapiens_hsa002300.76756743
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76728121
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75318093
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.75296202
54Tryptophan metabolism_Homo sapiens_hsa003800.73996154
55Protein export_Homo sapiens_hsa030600.73588068
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73269279
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70367070
58Homologous recombination_Homo sapiens_hsa034400.69413243
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.68670062
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68389809
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67868837
62Butanoate metabolism_Homo sapiens_hsa006500.61653601
63Measles_Homo sapiens_hsa051620.61626561
64One carbon pool by folate_Homo sapiens_hsa006700.60570211
65Salivary secretion_Homo sapiens_hsa049700.59650066
66Viral myocarditis_Homo sapiens_hsa054160.58139189
67Fat digestion and absorption_Homo sapiens_hsa049750.56822394
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55039619
69Metabolic pathways_Homo sapiens_hsa011000.54506723
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54153936
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53869496
72Morphine addiction_Homo sapiens_hsa050320.53796202
73Ovarian steroidogenesis_Homo sapiens_hsa049130.50675042
74Taste transduction_Homo sapiens_hsa047420.48551748
75Systemic lupus erythematosus_Homo sapiens_hsa053220.48298407
76Nucleotide excision repair_Homo sapiens_hsa034200.42846435
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42615261
78Serotonergic synapse_Homo sapiens_hsa047260.41886626
79Base excision repair_Homo sapiens_hsa034100.38841670
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34316321
81Glycerolipid metabolism_Homo sapiens_hsa005610.33685130
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33108378
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.32567192
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32149853
85Circadian entrainment_Homo sapiens_hsa047130.31029047
86Tyrosine metabolism_Homo sapiens_hsa003500.29189547
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.27647778
88Fatty acid degradation_Homo sapiens_hsa000710.27551957
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.26654512
90Propanoate metabolism_Homo sapiens_hsa006400.23214779
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.22387277
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.22373301
93Hedgehog signaling pathway_Homo sapiens_hsa043400.22166011
94GABAergic synapse_Homo sapiens_hsa047270.22025026
95Collecting duct acid secretion_Homo sapiens_hsa049660.21893890
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19083643
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18844872
98Herpes simplex infection_Homo sapiens_hsa051680.18775538
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18631978
100Calcium signaling pathway_Homo sapiens_hsa040200.18433926

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