ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.28229562
2	maturation of SSU-rRNA (GO:0030490)	6.15856670
3	ribosomal small subunit biogenesis (GO:0042274)	6.02242500
4	chaperone-mediated protein transport (GO:0072321)	5.67665370
5	viral transcription (GO:0019083)	5.46959381
6	translational termination (GO:0006415)	5.21688139
7	base-excision repair, AP site formation (GO:0006285)	4.93301052
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.65328773
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.60747353
10	ATP synthesis coupled proton transport (GO:0015986)	4.60747353
11	translational elongation (GO:0006414)	4.58998248
12	proteasome assembly (GO:0043248)	4.58845623
13	cotranslational protein targeting to membrane (GO:0006613)	4.55405224
14	protein targeting to ER (GO:0045047)	4.54598567
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.53545969
16	protein localization to endoplasmic reticulum (GO:0070972)	4.31366974
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.27775053
18	viral life cycle (GO:0019058)	4.19947992
19	mannosylation (GO:0097502)	4.11264556
20	DNA strand renaturation (GO:0000733)	4.07683310
21	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.04137674
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.02370455
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.02370455
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.97695259
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.97695259
26	NADH dehydrogenase complex assembly (GO:0010257)	3.97695259
27	male meiosis I (GO:0007141)	3.97057186
28	purine deoxyribonucleotide catabolic process (GO:0009155)	3.92784857
29	cellular protein complex disassembly (GO:0043624)	3.92694264
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.91537174
31	translational initiation (GO:0006413)	3.88644828
32	ribonucleoprotein complex biogenesis (GO:0022613)	3.88585708
33	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.84234813
34	protein complex biogenesis (GO:0070271)	3.80518682
35	piRNA metabolic process (GO:0034587)	3.77982174
36	synapsis (GO:0007129)	3.75279613
37	kinetochore assembly (GO:0051382)	3.73325596
38	ribosomal large subunit biogenesis (GO:0042273)	3.69765872
39	deoxyribonucleotide catabolic process (GO:0009264)	3.65864701
40	translation (GO:0006412)	3.64541001
41	cellular component biogenesis (GO:0044085)	3.64199321
42	respiratory electron transport chain (GO:0022904)	3.62676992
43	meiosis I (GO:0007127)	3.60599566
44	electron transport chain (GO:0022900)	3.58153921
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.51215888
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.49059063
47	metallo-sulfur cluster assembly (GO:0031163)	3.47140437
48	iron-sulfur cluster assembly (GO:0016226)	3.47140437
49	deoxyribose phosphate catabolic process (GO:0046386)	3.43802667
50	cell wall macromolecule catabolic process (GO:0016998)	3.41178964
51	regulation of mitochondrial translation (GO:0070129)	3.37445839
52	ubiquinone biosynthetic process (GO:0006744)	3.33453103
53	peptidyl-histidine modification (GO:0018202)	3.32848020
54	tRNA processing (GO:0008033)	3.31778888
55	protein complex disassembly (GO:0043241)	3.30688044
56	ribosome biogenesis (GO:0042254)	3.28983935
57	kinetochore organization (GO:0051383)	3.27925462
58	rRNA processing (GO:0006364)	3.27519066
59	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.27045158
60	protein-cofactor linkage (GO:0018065)	3.24701692
61	purine deoxyribonucleotide metabolic process (GO:0009151)	3.21166401
62	rRNA metabolic process (GO:0016072)	3.18891421
63	2-deoxyribonucleotide metabolic process (GO:0009394)	3.16292288
64	pyrimidine nucleotide catabolic process (GO:0006244)	3.14220614
65	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.10293380
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.08023762
67	regulation of cilium movement (GO:0003352)	3.06618141
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.05952292
69	macromolecular complex disassembly (GO:0032984)	3.05194039
70	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.00285830
71	meiotic chromosome segregation (GO:0045132)	2.98092930
72	aerobic respiration (GO:0009060)	2.97664318
73	protein targeting to mitochondrion (GO:0006626)	2.96948103
74	protein targeting to membrane (GO:0006612)	2.96452583
75	resolution of meiotic recombination intermediates (GO:0000712)	2.96261835
76	respiratory chain complex IV assembly (GO:0008535)	2.96084832
77	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.94912922
78	establishment of protein localization to mitochondrion (GO:0072655)	2.94138928
79	cytochrome complex assembly (GO:0017004)	2.92429163
80	positive regulation of prostaglandin secretion (GO:0032308)	2.92004295
81	platelet dense granule organization (GO:0060155)	2.89498285
82	deoxyribose phosphate metabolic process (GO:0019692)	2.88276191
83	pseudouridine synthesis (GO:0001522)	2.87688738
84	ubiquinone metabolic process (GO:0006743)	2.87122331
85	GTP biosynthetic process (GO:0006183)	2.86180028
86	ncRNA processing (GO:0034470)	2.86025994
87	protein neddylation (GO:0045116)	2.85392653
88	mRNA catabolic process (GO:0006402)	2.85382217
89	chromatin remodeling at centromere (GO:0031055)	2.83513956
90	chromosome organization involved in meiosis (GO:0070192)	2.82879109
91	UV protection (GO:0009650)	2.82336927
92	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.79281499
93	tRNA modification (GO:0006400)	2.78170131
94	tRNA metabolic process (GO:0006399)	2.76676255
95	rRNA modification (GO:0000154)	2.74532592
96	negative regulation of mast cell activation (GO:0033004)	2.73320771
97	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.72574736
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.71628110
99	DNA catabolic process, exonucleolytic (GO:0000738)	2.70773142
100	RNA catabolic process (GO:0006401)	2.69920957

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.18084056
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.02233118
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.95743972
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.74042438
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.31675239
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.30098682
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.20003016
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.12364314
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.89414141
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.80984389
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.77850329
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77465455
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.65668928
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.61105507
15	XRN2_22483619_ChIP-Seq_HELA_Human	2.58101393
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.55322907
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.38656551
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.34732011
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25627723
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.22395142
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19832443
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12853970
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.11982655
24	VDR_21846776_ChIP-Seq_THP-1_Human	2.09642376
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.05554336
26	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.03510645
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.98192907
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.96309590
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.93599695
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.90590569
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87364814
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.81044034
33	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.78161820
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.76512367
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74812371
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.74379421
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.74253492
38	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.72345640
39	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.72235403
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.65322539
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64464483
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63837828
43	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.63357452
44	BCL6_27268052_Chip-Seq_Bcells_Human	1.59913825
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59543747
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56649475
47	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55336634
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.48425356
49	P68_20966046_ChIP-Seq_HELA_Human	1.46146030
50	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.46129543
51	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.45711070
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.45528519
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.45192790
54	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.43813391
55	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.42655217
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.41569082
57	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.39033445
58	* E2F1_20622854_ChIP-Seq_HELA_Human	1.37594346
59	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.37017460
60	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.34900964
61	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.33908910
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32640834
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.32372016
64	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.30563976
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.27378859
66	* BCOR_27268052_Chip-Seq_Bcells_Human	1.26862432
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.25377279
68	MAF_26560356_Chip-Seq_TH2_Human	1.25273571
69	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.22698451
70	CTCF_20526341_ChIP-Seq_ESCs_Human	1.21018746
71	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.19141551
72	ERA_21632823_ChIP-Seq_H3396_Human	1.17314274
73	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16728874
74	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.15737658
75	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10535448
76	UTX_26944678_Chip-Seq_JUKART_Human	1.10441548
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09779733
78	* P300_27268052_Chip-Seq_Bcells_Human	1.09401781
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.07777676
80	E2F7_22180533_ChIP-Seq_HELA_Human	1.06620575
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06354643
82	* PHF8_20622854_ChIP-Seq_HELA_Human	1.05123371
83	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04679048
84	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.04573360
85	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02795337
86	TP53_22573176_ChIP-Seq_HFKS_Human	1.02079994
87	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.99419923
88	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.97509848
89	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.97487790
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.97212316
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94644923
92	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.94390190
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93848261
94	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.93742960
95	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92749893
96	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.92347284
97	ZNF274_21170338_ChIP-Seq_K562_Hela	0.92280158
98	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.90240433
99	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89299212
100	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.88549010

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.50687937
2	MP0008058_abnormal_DNA_repair	3.61590413
3	MP0005174_abnormal_tail_pigmentation	3.18738833
4	MP0003186_abnormal_redox_activity	2.81490066
5	MP0008875_abnormal_xenobiotic_pharmacok	2.61663840
6	MP0006292_abnormal_olfactory_placode	2.48986434
7	MP0000372_irregular_coat_pigmentation	2.40937213
8	MP0005171_absent_coat_pigmentation	2.26166904
9	MP0002160_abnormal_reproductive_system	2.21670527
10	MP0001986_abnormal_taste_sensitivity	2.19593998
11	MP0003136_yellow_coat_color	2.17520482
12	MP0006036_abnormal_mitochondrial_physio	2.13855010
13	MP0001764_abnormal_homeostasis	2.10948734
14	MP0010094_abnormal_chromosome_stability	2.08455719
15	MP0002163_abnormal_gland_morphology	2.05731480
16	MP0003646_muscle_fatigue	1.95946392
17	MP0003123_paternal_imprinting	1.94916176
18	MP0001835_abnormal_antigen_presentation	1.91199372
19	MP0003718_maternal_effect	1.85752596
20	MP0001293_anophthalmia	1.80463816
21	MP0008007_abnormal_cellular_replicative	1.77433508
22	MP0002132_abnormal_respiratory_system	1.74397064
23	MP0003806_abnormal_nucleotide_metabolis	1.73573929
24	MP0001905_abnormal_dopamine_level	1.68601947
25	MP0005423_abnormal_somatic_nervous	1.66878511
26	MP0002095_abnormal_skin_pigmentation	1.60207122
27	MP0005410_abnormal_fertilization	1.59761404
28	MP0002736_abnormal_nociception_after	1.56207531
29	MP0000015_abnormal_ear_pigmentation	1.54946553
30	MP0005389_reproductive_system_phenotype	1.52011972
31	MP0003786_premature_aging	1.48335016
32	MP0003111_abnormal_nucleus_morphology	1.47819412
33	MP0001853_heart_inflammation	1.45899634
34	MP0002837_dystrophic_cardiac_calcinosis	1.45441117
35	MP0001968_abnormal_touch/_nociception	1.44578135
36	MP0002210_abnormal_sex_determination	1.41269144
37	MP0003077_abnormal_cell_cycle	1.38682704
38	MP0002254_reproductive_system_inflammat	1.33029205
39	MP0003011_delayed_dark_adaptation	1.32987642
40	MP0009764_decreased_sensitivity_to	1.31809626
41	MP0001929_abnormal_gametogenesis	1.30132160
42	MP0005551_abnormal_eye_electrophysiolog	1.27413911
43	MP0004142_abnormal_muscle_tone	1.26919915
44	MP0002876_abnormal_thyroid_physiology	1.26414930
45	MP0004147_increased_porphyrin_level	1.26011969
46	MP0000358_abnormal_cell_content/	1.22628628
47	MP0000750_abnormal_muscle_regeneration	1.22097052
48	MP0005332_abnormal_amino_acid	1.21445633
49	MP0009333_abnormal_splenocyte_physiolog	1.20197007
50	MP0001545_abnormal_hematopoietic_system	1.19530187
51	MP0005397_hematopoietic_system_phenotyp	1.19530187
52	MP0002148_abnormal_hypersensitivity_rea	1.19460447
53	MP0003693_abnormal_embryo_hatching	1.18710779
54	MP0001919_abnormal_reproductive_system	1.11644075
55	MP0001145_abnormal_male_reproductive	1.10979156
56	MP0003698_abnormal_male_reproductive	1.03830042
57	MP0001800_abnormal_humoral_immune	1.03386290
58	MP0005075_abnormal_melanosome_morpholog	1.02702897
59	MP0000653_abnormal_sex_gland	1.01868217
60	MP0002234_abnormal_pharynx_morphology	1.00528113
61	MP0008789_abnormal_olfactory_epithelium	1.00151258
62	MP0002723_abnormal_immune_serum	0.98236414
63	MP0008872_abnormal_physiological_respon	0.97732145
64	MP0006035_abnormal_mitochondrial_morpho	0.97196931
65	MP0005670_abnormal_white_adipose	0.97183480
66	MP0004957_abnormal_blastocyst_morpholog	0.95969962
67	MP0002735_abnormal_chemical_nociception	0.95370497
68	MP0003763_abnormal_thymus_physiology	0.93690370
69	MP0005000_abnormal_immune_tolerance	0.92156790
70	MP0005084_abnormal_gallbladder_morpholo	0.91312977
71	MP0002420_abnormal_adaptive_immunity	0.90108732
72	MP0000685_abnormal_immune_system	0.90055083
73	MP0001819_abnormal_immune_cell	0.88872327
74	MP0002452_abnormal_antigen_presenting	0.86093562
75	MP0008469_abnormal_protein_level	0.86045927
76	MP0002938_white_spotting	0.84167607
77	MP0005645_abnormal_hypothalamus_physiol	0.83583661
78	MP0001756_abnormal_urination	0.83545085
79	MP0001324_abnormal_eye_pigmentation	0.83193439
80	MP0001661_extended_life_span	0.82040792
81	MP0006082_CNS_inflammation	0.81895399
82	MP0004019_abnormal_vitamin_homeostasis	0.80706484
83	MP0002019_abnormal_tumor_incidence	0.80650379
84	MP0001119_abnormal_female_reproductive	0.80344752
85	MP0002429_abnormal_blood_cell	0.78140482
86	MP0003436_decreased_susceptibility_to	0.78021738
87	MP0002398_abnormal_bone_marrow	0.77950281
88	MP0001873_stomach_inflammation	0.77602977
89	MP0000689_abnormal_spleen_morphology	0.76782143
90	MP0002405_respiratory_system_inflammati	0.76148522
91	MP0005025_abnormal_response_to	0.74125132
92	MP0000716_abnormal_immune_system	0.72119041
93	MP0005387_immune_system_phenotype	0.70938013
94	MP0001790_abnormal_immune_system	0.70938013
95	MP0004742_abnormal_vestibular_system	0.70192521
96	MP0005671_abnormal_response_to	0.69253819
97	MP0009278_abnormal_bone_marrow	0.69090039
98	MP0009785_altered_susceptibility_to	0.69003060
99	MP0001485_abnormal_pinna_reflex	0.68610816
100	MP0009643_abnormal_urine_homeostasis	0.68490577

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.98568953
2	Reticulocytopenia (HP:0001896)	4.80874933
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.59522969
4	Mitochondrial inheritance (HP:0001427)	4.50588788
5	Acute encephalopathy (HP:0006846)	4.44484763
6	Increased CSF lactate (HP:0002490)	4.33858155
7	Progressive macrocephaly (HP:0004481)	4.23454413
8	Hepatocellular necrosis (HP:0001404)	4.11585033
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.83632621
10	Abnormality of alanine metabolism (HP:0010916)	3.83632621
11	Hyperalaninemia (HP:0003348)	3.83632621
12	Increased hepatocellular lipid droplets (HP:0006565)	3.67368609
13	Hepatic necrosis (HP:0002605)	3.58387069
14	Increased intramyocellular lipid droplets (HP:0012240)	3.36572649
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.35291517
16	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.35009592
17	Cerebral edema (HP:0002181)	3.34947380
18	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.33900977
19	Lipid accumulation in hepatocytes (HP:0006561)	3.32048172
20	Rectovaginal fistula (HP:0000143)	3.19823078
21	Rectal fistula (HP:0100590)	3.19823078
22	Renal Fanconi syndrome (HP:0001994)	3.17260881
23	Absent thumb (HP:0009777)	3.17253431
24	Increased serum lactate (HP:0002151)	3.09909714
25	Abnormality of midbrain morphology (HP:0002418)	3.07090993
26	Molar tooth sign on MRI (HP:0002419)	3.07090993
27	Abnormal number of erythroid precursors (HP:0012131)	3.01888592
28	Lactic acidosis (HP:0003128)	2.96006304
29	Testicular atrophy (HP:0000029)	2.95142932
30	Macrocytic anemia (HP:0001972)	2.91844637
31	Increased muscle lipid content (HP:0009058)	2.90381656
32	3-Methylglutaconic aciduria (HP:0003535)	2.88322574
33	Exertional dyspnea (HP:0002875)	2.87900509
34	Respiratory difficulties (HP:0002880)	2.84500008
35	Pallor (HP:0000980)	2.80572841
36	Rib fusion (HP:0000902)	2.76550492
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.75754344
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.75754344
39	Optic disc pallor (HP:0000543)	2.75668083
40	Microretrognathia (HP:0000308)	2.74357867
41	Type I transferrin isoform profile (HP:0003642)	2.68219517
42	Abnormality of DNA repair (HP:0003254)	2.67510076
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.65168161
44	Poikiloderma (HP:0001029)	2.63436360
45	Vaginal fistula (HP:0004320)	2.58922207
46	Intestinal fistula (HP:0100819)	2.49486653
47	Congenital stationary night blindness (HP:0007642)	2.48097267
48	Chronic hepatic failure (HP:0100626)	2.42865080
49	Exercise intolerance (HP:0003546)	2.37853267
50	Microvesicular hepatic steatosis (HP:0001414)	2.25661984
51	Attenuation of retinal blood vessels (HP:0007843)	2.25658989
52	Lethargy (HP:0001254)	2.23965827
53	Cerebral hypomyelination (HP:0006808)	2.19225793
54	Abnormality of T cell physiology (HP:0011840)	2.17950386
55	Respiratory failure (HP:0002878)	2.12242695
56	Leukodystrophy (HP:0002415)	2.09922585
57	Cerebellar dysplasia (HP:0007033)	2.09274356
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.08234606
59	Abnormal protein glycosylation (HP:0012346)	2.08234606
60	Abnormal glycosylation (HP:0012345)	2.08234606
61	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.08234606
62	Agammaglobulinemia (HP:0004432)	2.07368179
63	Increased IgM level (HP:0003496)	2.05762501
64	CNS demyelination (HP:0007305)	2.01579643
65	Cutaneous melanoma (HP:0012056)	1.99988098
66	Squamous cell carcinoma (HP:0002860)	1.97414972
67	Bile duct proliferation (HP:0001408)	1.96554750
68	Abnormal biliary tract physiology (HP:0012439)	1.96554750
69	Tachypnea (HP:0002789)	1.96137455
70	Emotional lability (HP:0000712)	1.95981654
71	Cleft eyelid (HP:0000625)	1.94016847
72	Thrombocytosis (HP:0001894)	1.93543699
73	Hypertensive crisis (HP:0100735)	1.91964980
74	Optic nerve coloboma (HP:0000588)	1.91167251
75	Pancreatic cysts (HP:0001737)	1.89794423
76	True hermaphroditism (HP:0010459)	1.88994411
77	Hyperglycinemia (HP:0002154)	1.86524841
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.85297351
79	Abnormality of serum amino acid levels (HP:0003112)	1.85000823
80	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.84685547
81	Neutropenia (HP:0001875)	1.83211099
82	Nausea (HP:0002018)	1.80964821
83	Pancreatic fibrosis (HP:0100732)	1.80286516
84	Stomatitis (HP:0010280)	1.80245158
85	Progressive microcephaly (HP:0000253)	1.79969579
86	Muscle fiber atrophy (HP:0100295)	1.79843541
87	Aplastic anemia (HP:0001915)	1.78397195
88	Abnormality of renal resorption (HP:0011038)	1.77867782
89	Increased serum pyruvate (HP:0003542)	1.76211184
90	Nephronophthisis (HP:0000090)	1.75982196
91	Recurrent cutaneous fungal infections (HP:0011370)	1.75682347
92	Chronic mucocutaneous candidiasis (HP:0002728)	1.75682347
93	Methylmalonic aciduria (HP:0012120)	1.74812246
94	IgG deficiency (HP:0004315)	1.74524446
95	Hypoplasia of the radius (HP:0002984)	1.74224483
96	Type 2 muscle fiber atrophy (HP:0003554)	1.71981035
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71408245
98	Glycosuria (HP:0003076)	1.68551163
99	Abnormality of urine glucose concentration (HP:0011016)	1.68551163
100	Pancytopenia (HP:0001876)	1.68513002

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.03454041
2	VRK2	4.78060174
3	NEK1	3.54175431
4	CDK19	3.21591882
5	STK16	2.80774461
6	NUAK1	2.60566547
7	KDR	2.51438336
8	NME2	2.47891293
9	BUB1	2.27316449
10	NEK2	2.19147588
11	BCKDK	2.18705118
12	TESK2	2.15877901
13	SCYL2	2.13380774
14	ZAK	2.09135179
15	TLK1	1.85183702
16	CCNB1	1.81916661
17	PLK4	1.72590265
18	VRK1	1.67106594
19	MAPKAPK5	1.66708963
20	WNK4	1.66432246
21	TAOK3	1.60997589
22	MAPK15	1.57579147
23	MAPKAPK3	1.56951781
24	PNCK	1.49923815
25	ABL2	1.47383093
26	MAP4K2	1.34320158
27	NME1	1.34119275
28	BRSK2	1.28351974
29	PBK	1.23284637
30	ADRBK2	1.21276228
31	OXSR1	1.20936322
32	DYRK2	1.16291127
33	CSF1R	1.14488096
34	TXK	1.13699083
35	IKBKB	1.12099532
36	MUSK	1.06560543
37	PIM2	0.96756043
38	MAPK13	0.94939089
39	TYK2	0.93393502
40	TRPM7	0.86203571
41	EEF2K	0.85150499
42	CDK4	0.83562490
43	RPS6KB2	0.81456609
44	PLK1	0.78783634
45	AURKA	0.77942779
46	RPS6KA5	0.77280248
47	CDC7	0.73705755
48	MAPK11	0.72020550
49	ATR	0.71724945
50	CHEK2	0.69734590
51	SIK2	0.68054249
52	MAPK12	0.67988401
53	PINK1	0.67147796
54	MAP3K11	0.66551693
55	EIF2AK1	0.63702949
56	BLK	0.62289941
57	BMX	0.62102422
58	WNK3	0.61883771
59	DAPK3	0.60741398
60	CDK11A	0.59230603
61	MARK3	0.59196710
62	GRK1	0.56847783
63	AURKB	0.56800098
64	ILK	0.53361325
65	CAMKK2	0.53333169
66	IKBKE	0.53079673
67	MAP4K1	0.52484655
68	KIT	0.52298500
69	LYN	0.52042848
70	TEC	0.49847299
71	BRSK1	0.48274757
72	CDK15	0.48125808
73	TAOK2	0.45228177
74	IRAK3	0.44724167
75	CAMK1	0.42425108
76	ADRBK1	0.41110339
77	PDPK1	0.40750795
78	CDK18	0.40102193
79	TIE1	0.39052327
80	PIM1	0.37704112
81	CDK14	0.37333717
82	PRKCQ	0.36839429
83	CSNK2A2	0.36728653
84	MAP2K2	0.36230259
85	PAK1	0.35695906
86	RPS6KA6	0.34954330
87	TBK1	0.34930269
88	SRPK1	0.34717048
89	CSNK2A1	0.34670332
90	NEK6	0.34095722
91	MST1R	0.33818420
92	RPS6KA1	0.33348665
93	CHEK1	0.33125993
94	SYK	0.32733305
95	STK4	0.30792999
96	IRAK4	0.29646076
97	ACVR1B	0.29497912
98	RPS6KL1	0.28851210
99	RPS6KC1	0.28851210
100	IRAK2	0.28598740

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.96676441
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.70084209
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.36841486
4	Parkinsons disease_Homo sapiens_hsa05012	2.95332819
5	Proteasome_Homo sapiens_hsa03050	2.92643580
6	Sulfur relay system_Homo sapiens_hsa04122	2.59664283
7	Asthma_Homo sapiens_hsa05310	2.44900932
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.36935463
9	Homologous recombination_Homo sapiens_hsa03440	2.36761465
10	DNA replication_Homo sapiens_hsa03030	2.25728587
11	Base excision repair_Homo sapiens_hsa03410	2.17637776
12	RNA polymerase_Homo sapiens_hsa03020	2.15459815
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.06377004
14	One carbon pool by folate_Homo sapiens_hsa00670	2.05719093
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.01241081
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96790799
17	Huntingtons disease_Homo sapiens_hsa05016	1.94796054
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.92034397
19	Mismatch repair_Homo sapiens_hsa03430	1.90252434
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81654894
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.74334493
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.73845760
23	Alzheimers disease_Homo sapiens_hsa05010	1.70332013
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.70094820
25	Allograft rejection_Homo sapiens_hsa05330	1.64880142
26	Glutathione metabolism_Homo sapiens_hsa00480	1.55309269
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.46889253
28	Protein export_Homo sapiens_hsa03060	1.41251471
29	RNA transport_Homo sapiens_hsa03013	1.33610285
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32268776
31	Basal transcription factors_Homo sapiens_hsa03022	1.32220413
32	Fatty acid elongation_Homo sapiens_hsa00062	1.27284779
33	Spliceosome_Homo sapiens_hsa03040	1.25599586
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25361723
35	RNA degradation_Homo sapiens_hsa03018	1.20525408
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.15666997
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15532045
38	Purine metabolism_Homo sapiens_hsa00230	1.11075823
39	Sulfur metabolism_Homo sapiens_hsa00920	1.10317741
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08751486
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05925796
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01139069
43	Folate biosynthesis_Homo sapiens_hsa00790	0.96760375
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95429648
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.94267152
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90432685
47	Peroxisome_Homo sapiens_hsa04146	0.90152060
48	Propanoate metabolism_Homo sapiens_hsa00640	0.88215254
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84797172
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80513255
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.80232899
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77305562
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.77040188
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76736363
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76371605
56	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.76170133
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75693657
58	Metabolic pathways_Homo sapiens_hsa01100	0.73682746
59	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.70438916
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.67447907
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.61792128
62	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.61583302
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60661466
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.56693243
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55936303
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55129948
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50194254
68	Butanoate metabolism_Homo sapiens_hsa00650	0.48486558
69	Phenylalanine metabolism_Homo sapiens_hsa00360	0.48190048
70	Leishmaniasis_Homo sapiens_hsa05140	0.44281508
71	Cell cycle_Homo sapiens_hsa04110	0.43025492
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42826925
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.42353563
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40653309
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38446438
76	Carbon metabolism_Homo sapiens_hsa01200	0.37680186
77	p53 signaling pathway_Homo sapiens_hsa04115	0.36757859
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35558911
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35332702
80	Phototransduction_Homo sapiens_hsa04744	0.34572442
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33475055
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.33159316
83	Fatty acid degradation_Homo sapiens_hsa00071	0.31988206
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.29496033
85	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29061935
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27741768
87	Viral myocarditis_Homo sapiens_hsa05416	0.27054246
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.26546299
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.26283099
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.25831461
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25751023
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.25732313
93	Herpes simplex infection_Homo sapiens_hsa05168	0.25426337
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.24396435
95	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24081574
96	Nitrogen metabolism_Homo sapiens_hsa00910	0.23941613
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.22843335
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.22432938
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.20804582
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.18600657

RPS2P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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