RPS2P35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.46155469
2viral transcription (GO:0019083)9.25337145
3ribosomal small subunit assembly (GO:0000028)9.02123879
4translational termination (GO:0006415)8.80002910
5maturation of SSU-rRNA (GO:0030490)8.56002985
6translational elongation (GO:0006414)7.33300152
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.25460382
8cotranslational protein targeting to membrane (GO:0006613)7.20746211
9protein targeting to ER (GO:0045047)7.16761894
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.84055083
11cellular protein complex disassembly (GO:0043624)6.77138521
12protein localization to endoplasmic reticulum (GO:0070972)6.75033913
13viral life cycle (GO:0019058)6.56764640
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.47890033
15ATP synthesis coupled proton transport (GO:0015986)5.78868525
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.78868525
17protein complex disassembly (GO:0043241)5.78822426
18translational initiation (GO:0006413)5.54981750
19macromolecular complex disassembly (GO:0032984)5.46074772
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.26101019
21positive regulation of respiratory burst (GO:0060267)5.00113443
22protein targeting to membrane (GO:0006612)4.91269948
23ribosomal large subunit biogenesis (GO:0042273)4.84325040
24chaperone-mediated protein transport (GO:0072321)4.61686651
25behavioral response to nicotine (GO:0035095)4.60469475
26nuclear-transcribed mRNA catabolic process (GO:0000956)4.31325484
27translation (GO:0006412)4.16240055
28mRNA catabolic process (GO:0006402)4.09715043
29respiratory electron transport chain (GO:0022904)4.05014884
30electron transport chain (GO:0022900)4.04469839
31substrate-independent telencephalic tangential migration (GO:0021826)3.96525862
32substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.96525862
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95171314
34hypothalamus development (GO:0021854)3.91435080
35protein neddylation (GO:0045116)3.87093345
36ribonucleoprotein complex biogenesis (GO:0022613)3.86663809
37nonmotile primary cilium assembly (GO:0035058)3.72123745
38auditory receptor cell differentiation (GO:0042491)3.71867068
39RNA catabolic process (GO:0006401)3.69263688
40cell proliferation in forebrain (GO:0021846)3.57350461
41ncRNA 3-end processing (GO:0043628)3.56428028
42cellular component biogenesis (GO:0044085)3.46766372
43pattern specification involved in kidney development (GO:0061004)3.45493861
44regulation of microtubule-based movement (GO:0060632)3.41406082
45negative regulation of appetite (GO:0032099)3.33141156
46negative regulation of response to food (GO:0032096)3.33141156
47establishment of protein localization to membrane (GO:0090150)3.31633412
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31214124
49regulation of cilium movement (GO:0003352)3.24032920
50ATP biosynthetic process (GO:0006754)3.23088505
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.20254322
52NADH dehydrogenase complex assembly (GO:0010257)3.20254322
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20254322
54hydrogen ion transmembrane transport (GO:1902600)3.19754583
55protein targeting (GO:0006605)3.18105894
56protein complex biogenesis (GO:0070271)3.15948212
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15419341
58pyrimidine nucleobase catabolic process (GO:0006208)3.13299794
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11448340
60regulation of respiratory burst (GO:0060263)3.05429053
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04221585
62axonemal dynein complex assembly (GO:0070286)3.00058520
63tongue development (GO:0043586)2.98631149
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.92067916
65GTP biosynthetic process (GO:0006183)2.91133655
66positive regulation of T cell apoptotic process (GO:0070234)2.88866177
67short-term memory (GO:0007614)2.85674899
68establishment of protein localization to organelle (GO:0072594)2.84292309
69pyrimidine nucleotide catabolic process (GO:0006244)2.83274518
70proton transport (GO:0015992)2.82463329
71nucleobase catabolic process (GO:0046113)2.82450786
72phosphatidylserine acyl-chain remodeling (GO:0036150)2.79574178
73mitochondrial respiratory chain complex assembly (GO:0033108)2.77635595
74hydrogen transport (GO:0006818)2.75651521
75protein localization to membrane (GO:0072657)2.72017802
76ubiquinone biosynthetic process (GO:0006744)2.68982578
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67984442
78establishment of mitochondrion localization (GO:0051654)2.65589254
79neuron fate determination (GO:0048664)2.63958991
80phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.59271895
81somite development (GO:0061053)2.53905489
82mitochondrion transport along microtubule (GO:0047497)2.52539874
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52539874
84regulation of cellular respiration (GO:0043457)2.52172985
85positive regulation of sodium ion transmembrane transport (GO:1902307)2.50124610
86UTP biosynthetic process (GO:0006228)2.49232672
87quinone biosynthetic process (GO:1901663)2.48241651
88protein polyglutamylation (GO:0018095)2.47737371
89arginine metabolic process (GO:0006525)2.47722391
90ncRNA catabolic process (GO:0034661)2.46960692
91head development (GO:0060322)2.46852522
92rRNA processing (GO:0006364)2.45574806
93segment specification (GO:0007379)2.45571317
94regulation of guanylate cyclase activity (GO:0031282)2.45468616
95water-soluble vitamin biosynthetic process (GO:0042364)2.45282780
96rRNA metabolic process (GO:0016072)2.44396523
97ubiquinone metabolic process (GO:0006743)2.41720535
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.41305920
99cardiovascular system development (GO:0072358)2.41021617
100nephron tubule morphogenesis (GO:0072078)2.40794456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.17229781
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.14648144
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59577933
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47507048
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.27121381
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19936873
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.14875281
8EZH2_27294783_Chip-Seq_ESCs_Mouse2.06344234
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00450644
10CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97732521
11JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94106195
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.89601927
13SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79173766
14CTCF_27219007_Chip-Seq_Bcells_Human1.77137914
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.74977360
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73611497
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68198934
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67699653
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64517096
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64447943
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.63593362
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.61894693
23TTF2_22483619_ChIP-Seq_HELA_Human1.59084543
24IRF1_19129219_ChIP-ChIP_H3396_Human1.57864847
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.55753148
26ZNF274_21170338_ChIP-Seq_K562_Hela1.55528515
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.54580643
28XRN2_22483619_ChIP-Seq_HELA_Human1.53958412
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53244799
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.52579539
31SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.51851187
32KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50676045
33VDR_22108803_ChIP-Seq_LS180_Human1.50142956
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49797933
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48922282
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48922282
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45185170
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41566967
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41254773
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40273657
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.39623853
42REST_21632747_ChIP-Seq_MESCs_Mouse1.36238031
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36128667
44CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35347335
45ERA_21632823_ChIP-Seq_H3396_Human1.34968574
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34548738
47TAF2_19829295_ChIP-Seq_ESCs_Human1.33197078
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32887961
49SA1_27219007_Chip-Seq_Bcells_Human1.30641690
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.28585661
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28371129
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28047691
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26978778
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25391034
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23533166
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.21326541
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.20338452
58BCL6_27268052_Chip-Seq_Bcells_Human1.20046714
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19854230
60NANOG_20526341_ChIP-Seq_ESCs_Human1.19652592
61TP53_22573176_ChIP-Seq_HFKS_Human1.19558426
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.18780353
63CTCF_20526341_ChIP-Seq_ESCs_Human1.18387472
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.17706057
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16231366
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16098226
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14752103
68MYC_18940864_ChIP-ChIP_HL60_Human1.14670410
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.14159538
70OCT4_19829295_ChIP-Seq_ESCs_Human1.11606440
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11011017
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10840757
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10771560
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10122401
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09918003
76P53_21459846_ChIP-Seq_SAOS-2_Human1.09372886
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09330173
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09066052
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08709233
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08225348
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05547702
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.03142837
83P68_20966046_ChIP-Seq_HELA_Human1.00745043
84E2F1_20622854_ChIP-Seq_HELA_Human1.00734153
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99934005
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99724988
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98908710
88GABP_19822575_ChIP-Seq_HepG2_Human0.97819912
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97380721
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96638764
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96496457
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95601079
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.95491812
94STAT1_20625510_ChIP-Seq_HELA_Human0.94102205
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93871523
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.91222491
97NCOR_22424771_ChIP-Seq_293T_Human0.90878979
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90451888
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90355305
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89862253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.78244758
2MP0006292_abnormal_olfactory_placode4.02041842
3MP0003123_paternal_imprinting2.94868574
4MP0003787_abnormal_imprinting2.86292471
5MP0008789_abnormal_olfactory_epithelium2.63494940
6MP0003122_maternal_imprinting2.62402469
7MP0005394_taste/olfaction_phenotype2.34079282
8MP0005499_abnormal_olfactory_system2.34079282
9MP0001293_anophthalmia2.28985292
10MP0003878_abnormal_ear_physiology2.20942880
11MP0005377_hearing/vestibular/ear_phenot2.20942880
12MP0001485_abnormal_pinna_reflex2.19739635
13MP0001348_abnormal_lacrimal_gland2.17780079
14MP0010030_abnormal_orbit_morphology2.03204195
15MP0003121_genomic_imprinting2.02006589
16MP0004142_abnormal_muscle_tone1.92854627
17MP0005645_abnormal_hypothalamus_physiol1.85998980
18MP0003136_yellow_coat_color1.79536142
19MP0005360_urolithiasis1.76873965
20MP0000049_abnormal_middle_ear1.75206030
21MP0002163_abnormal_gland_morphology1.74975125
22MP0008877_abnormal_DNA_methylation1.73978621
23MP0003879_abnormal_hair_cell1.73540176
24MP0000778_abnormal_nervous_system1.70419784
25MP0002653_abnormal_ependyma_morphology1.69577763
26MP0006276_abnormal_autonomic_nervous1.68151810
27MP0002160_abnormal_reproductive_system1.65712727
28MP0004885_abnormal_endolymph1.54870173
29MP0003315_abnormal_perineum_morphology1.43587836
30MP0004858_abnormal_nervous_system1.41101202
31MP0001968_abnormal_touch/_nociception1.40703728
32MP0004742_abnormal_vestibular_system1.38329638
33MP0008872_abnormal_physiological_respon1.38128349
34MP0003646_muscle_fatigue1.33549950
35MP0000566_synostosis1.30514799
36MP0005379_endocrine/exocrine_gland_phen1.29637896
37MP0002736_abnormal_nociception_after1.29008939
38MP0005389_reproductive_system_phenotype1.28941036
39MP0002272_abnormal_nervous_system1.26219750
40MP0002557_abnormal_social/conspecific_i1.25069876
41MP0005551_abnormal_eye_electrophysiolog1.23016286
42MP0001440_abnormal_grooming_behavior1.22934362
43MP0002638_abnormal_pupillary_reflex1.19654760
44MP0001970_abnormal_pain_threshold1.18073627
45MP0003880_abnormal_central_pattern1.17117891
46MP0002938_white_spotting1.16528186
47MP0004145_abnormal_muscle_electrophysio1.16322464
48MP0003183_abnormal_peptide_metabolism1.16279268
49MP0002733_abnormal_thermal_nociception1.15536036
50MP0000026_abnormal_inner_ear1.13067963
51MP0002876_abnormal_thyroid_physiology1.12036294
52MP0001905_abnormal_dopamine_level1.11129352
53MP0003938_abnormal_ear_development1.11105596
54MP0005195_abnormal_posterior_eye1.10987716
55MP0000631_abnormal_neuroendocrine_gland1.08366706
56MP0004019_abnormal_vitamin_homeostasis1.07685108
57MP0005174_abnormal_tail_pigmentation1.05355524
58MP0002184_abnormal_innervation1.03723822
59MP0004133_heterotaxia1.02552418
60MP0005646_abnormal_pituitary_gland1.02355350
61MP0002752_abnormal_somatic_nervous1.02068494
62MP0003942_abnormal_urinary_system0.99618950
63MP0001919_abnormal_reproductive_system0.97005338
64MP0005083_abnormal_biliary_tract0.96772756
65MP0002095_abnormal_skin_pigmentation0.95823683
66MP0002249_abnormal_larynx_morphology0.95070684
67MP0002233_abnormal_nose_morphology0.94745723
68MP0000955_abnormal_spinal_cord0.93037258
69MP0001663_abnormal_digestive_system0.91734119
70MP0002822_catalepsy0.91652616
71MP0005084_abnormal_gallbladder_morpholo0.91540882
72MP0003635_abnormal_synaptic_transmissio0.90826139
73MP0001502_abnormal_circadian_rhythm0.90475519
74MP0001986_abnormal_taste_sensitivity0.88344152
75MP0009053_abnormal_anal_canal0.87929427
76MP0002063_abnormal_learning/memory/cond0.87879419
77MP0003937_abnormal_limbs/digits/tail_de0.87713738
78MP0002572_abnormal_emotion/affect_behav0.87430849
79MP0009745_abnormal_behavioral_response0.87407935
80MP0002734_abnormal_mechanical_nocicepti0.86700971
81MP0004043_abnormal_pH_regulation0.85861826
82MP0001963_abnormal_hearing_physiology0.80349662
83MP0002735_abnormal_chemical_nociception0.79447631
84MP0008875_abnormal_xenobiotic_pharmacok0.79327163
85MP0002234_abnormal_pharynx_morphology0.78681867
86MP0001188_hyperpigmentation0.77804423
87MP0005423_abnormal_somatic_nervous0.77182206
88MP0001286_abnormal_eye_development0.76865600
89MP0002210_abnormal_sex_determination0.76716986
90MP0002882_abnormal_neuron_morphology0.76357156
91MP0004147_increased_porphyrin_level0.76262385
92MP0003283_abnormal_digestive_organ0.74984670
93MP0002697_abnormal_eye_size0.74500048
94MP0005381_digestive/alimentary_phenotyp0.72915507
95MP0002092_abnormal_eye_morphology0.71704354
96MP0003755_abnormal_palate_morphology0.71640011
97MP0002152_abnormal_brain_morphology0.71276623
98MP0001984_abnormal_olfaction0.70943668
99MP0003718_maternal_effect0.70504927
100MP0002064_seizures0.70370489

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.52797770
2Abnormality of cells of the erythroid lineage (HP:0012130)5.07640331
3Macrocytic anemia (HP:0001972)4.52029294
4Rib fusion (HP:0000902)3.96883605
5Aplasia/Hypoplasia of the sacrum (HP:0008517)3.96307608
6Acute necrotizing encephalopathy (HP:0006965)3.86488086
7Abnormality of midbrain morphology (HP:0002418)3.78557729
8Molar tooth sign on MRI (HP:0002419)3.78557729
9Abnormal number of erythroid precursors (HP:0012131)3.61003251
10Abnormal mitochondria in muscle tissue (HP:0008316)3.50372293
11Acute encephalopathy (HP:0006846)3.44709006
12Partial duplication of thumb phalanx (HP:0009944)3.41864735
13Pallor (HP:0000980)3.41703125
14Septo-optic dysplasia (HP:0100842)3.31811463
15Pancreatic fibrosis (HP:0100732)3.22380516
16Mitochondrial inheritance (HP:0001427)2.98628062
17Absent thumb (HP:0009777)2.95905367
18Progressive macrocephaly (HP:0004481)2.95228718
19Anophthalmia (HP:0000528)2.92290460
20Partial duplication of the phalanx of hand (HP:0009999)2.82137381
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.81632362
2211 pairs of ribs (HP:0000878)2.78882502
23Pendular nystagmus (HP:0012043)2.75852904
24Hypoplasia of the radius (HP:0002984)2.74404785
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.70409017
26Myokymia (HP:0002411)2.64762177
27Asplenia (HP:0001746)2.62715019
28Medial flaring of the eyebrow (HP:0010747)2.60832029
29Bifid tongue (HP:0010297)2.59613091
30Sclerocornea (HP:0000647)2.57060362
31Pancreatic cysts (HP:0001737)2.56657299
32Ectopic kidney (HP:0000086)2.54220877
33Increased CSF lactate (HP:0002490)2.51971924
34Type II lissencephaly (HP:0007260)2.51419405
35Abnormality of the labia minora (HP:0012880)2.47982939
36Colon cancer (HP:0003003)2.46590578
37Missing ribs (HP:0000921)2.46556375
38Supernumerary spleens (HP:0009799)2.46320811
39Polyphagia (HP:0002591)2.43353076
40Cerebral edema (HP:0002181)2.42510879
41Hyperglycinemia (HP:0002154)2.37781991
42Stenosis of the external auditory canal (HP:0000402)2.37520346
43Abnormal rod and cone electroretinograms (HP:0008323)2.34361342
44Hyperthyroidism (HP:0000836)2.30955730
45Anencephaly (HP:0002323)2.30488796
46Hepatocellular necrosis (HP:0001404)2.25860404
47Gait imbalance (HP:0002141)2.25752444
48Depressed nasal ridge (HP:0000457)2.22643444
49Abnormal ciliary motility (HP:0012262)2.17263595
50Abnormality of the phalanges of the hallux (HP:0010057)2.14263282
51Forearm undergrowth (HP:0009821)2.10861068
52Hepatic necrosis (HP:0002605)2.09772689
53Increased hepatocellular lipid droplets (HP:0006565)2.09441743
54Duplication of thumb phalanx (HP:0009942)2.08994785
55True hermaphroditism (HP:0010459)2.08307805
56Abnormal hemoglobin (HP:0011902)2.07604235
57Lipid accumulation in hepatocytes (HP:0006561)2.06799853
58Maternal diabetes (HP:0009800)2.01008577
59Pachygyria (HP:0001302)2.00771240
60Congenital primary aphakia (HP:0007707)2.00383939
61Bile duct proliferation (HP:0001408)2.00098839
62Abnormal biliary tract physiology (HP:0012439)2.00098839
63Abnormal respiratory motile cilium physiology (HP:0012261)1.98811513
64Symphalangism affecting the phalanges of the hand (HP:0009773)1.98207693
65Horseshoe kidney (HP:0000085)1.97447003
66Abnormality of DNA repair (HP:0003254)1.95088496
67Optic disc pallor (HP:0000543)1.94893091
68Absent septum pellucidum (HP:0001331)1.91185099
69Congenital stationary night blindness (HP:0007642)1.88309757
70Tubular atrophy (HP:0000092)1.87872026
71Nephrogenic diabetes insipidus (HP:0009806)1.87284612
72Cystic liver disease (HP:0006706)1.87033246
73Occipital encephalocele (HP:0002085)1.86376752
74Abnormality of urine glucose concentration (HP:0011016)1.85935174
75Glycosuria (HP:0003076)1.85935174
76Triphalangeal thumb (HP:0001199)1.85319740
77Postaxial foot polydactyly (HP:0001830)1.82903369
78Lissencephaly (HP:0001339)1.82462758
79Hypoplasia of the ulna (HP:0003022)1.81981412
80Microretrognathia (HP:0000308)1.81452310
81Abnormality of reticulocytes (HP:0004312)1.81291534
82Increased intramyocellular lipid droplets (HP:0012240)1.80746290
83Vaginal atresia (HP:0000148)1.80550894
84Lethargy (HP:0001254)1.78862377
85Double outlet right ventricle (HP:0001719)1.77767505
86Congenital malformation of the right heart (HP:0011723)1.77767505
87Abnormality of the phalanges of the 5th finger (HP:0004213)1.77516736
88Renal duplication (HP:0000075)1.74786544
89Nephronophthisis (HP:0000090)1.74666837
90Abnormality of the aortic arch (HP:0012303)1.74380423
91Genital tract atresia (HP:0001827)1.74307368
92Lactic acidosis (HP:0003128)1.73948722
93Esophageal atresia (HP:0002032)1.72501646
94Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72384399
95Hypoplasia of the brainstem (HP:0002365)1.72384399
96Renal Fanconi syndrome (HP:0001994)1.70671806
97Chronic hepatic failure (HP:0100626)1.70135822
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68054242
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68054242
100Left ventricular hypertrophy (HP:0001712)1.67967276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.27204270
2STK163.72470738
3EPHB23.16924453
4MAP2K72.75313655
5DYRK22.59939525
6LRRK22.59278507
7ADRBK22.53464377
8NME22.20884507
9CDK192.08796149
10GRK12.02013679
11MAP3K111.99323452
12CDC71.83159472
13CASK1.77498438
14MAP3K41.76088688
15BCKDK1.74625497
16STK391.70428849
17WNK11.68911139
18PINK11.47056500
19TYRO31.42335418
20CAMK11.42250369
21TLK11.41838215
22CAMKK21.39449889
23NTRK21.38363751
24WNK31.36992993
25MARK11.36149327
26PIK3CA1.34005462
27PRKCG1.33566006
28NUAK11.28764738
29EPHA41.27394705
30TIE11.26241073
31BRAF1.26200595
32CAMKK11.24962803
33DMPK1.24845223
34MINK11.23532100
35VRK21.19662847
36PRKCI1.17455176
37SIK21.16495587
38PDK21.14002653
39AURKA1.12578529
40ARAF1.11592438
41MAP2K41.01868811
42DYRK1B1.01414336
43MARK21.01135884
44PIM20.99318745
45LIMK10.96957977
46ABL20.94635793
47RPS6KA60.88847007
48PRKCH0.87999978
49MAP3K90.87434224
50STK110.87381005
51PRKCZ0.86591648
52ZAK0.86452949
53PTK60.86043483
54DAPK30.85323351
55CSNK1E0.82513095
56CSNK2A20.79804222
57BRSK10.78254197
58PRKCQ0.75283057
59TAF10.74987067
60RPS6KC10.74652464
61RPS6KL10.74652464
62PRKACA0.72318361
63BMPR1B0.70588027
64ADRBK10.69814371
65MAP2K20.69652206
66RPS6KA20.68978083
67AURKB0.67677765
68BRSK20.67400268
69TXK0.63189554
70PNCK0.58687820
71INSRR0.58147028
72PHKG10.57994218
73PHKG20.57994218
74MAPK130.57871461
75RPS6KA50.57610086
76PRKCD0.57582901
77PLK10.56894338
78PAK30.55989510
79OXSR10.55113783
80CSNK1A10.53821667
81PRKD30.51965494
82NEK10.51451599
83CAMK1D0.49056656
84PRKCA0.49051634
85TNIK0.48720370
86MAP4K20.48710901
87SGK10.48301730
88SGK2230.46693312
89SGK4940.46693312
90CAMK2A0.43525847
91FRK0.43036353
92NEK20.42205290
93CSNK2A10.41792698
94CDK140.39844521
95CAMK2D0.38059518
96PRKACG0.37926751
97PRKDC0.37265274
98CSNK1G20.36683801
99CAMK40.35924218
100VRK10.35771418

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.38068632
2Oxidative phosphorylation_Homo sapiens_hsa001904.37532285
3Parkinsons disease_Homo sapiens_hsa050123.62635869
4Cardiac muscle contraction_Homo sapiens_hsa042603.13590438
5Huntingtons disease_Homo sapiens_hsa050162.69101341
6Linoleic acid metabolism_Homo sapiens_hsa005912.57934151
7Alzheimers disease_Homo sapiens_hsa050102.57398311
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51007276
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.47543798
10Fat digestion and absorption_Homo sapiens_hsa049752.41721237
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25588765
12Sulfur relay system_Homo sapiens_hsa041222.07714286
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.61196764
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51766829
15Vitamin digestion and absorption_Homo sapiens_hsa049771.48924414
16Ether lipid metabolism_Homo sapiens_hsa005651.46375310
17RNA polymerase_Homo sapiens_hsa030201.46131595
18Caffeine metabolism_Homo sapiens_hsa002321.44666644
19Arachidonic acid metabolism_Homo sapiens_hsa005901.34365147
20Phototransduction_Homo sapiens_hsa047441.30012294
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27164853
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15044993
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14106718
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11196726
25Steroid biosynthesis_Homo sapiens_hsa001001.06992910
26Pyrimidine metabolism_Homo sapiens_hsa002401.02392138
27Homologous recombination_Homo sapiens_hsa034401.01922158
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00733012
29Fatty acid degradation_Homo sapiens_hsa000711.00328441
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98971221
31Protein export_Homo sapiens_hsa030600.98681183
32RNA degradation_Homo sapiens_hsa030180.97367908
33Chemical carcinogenesis_Homo sapiens_hsa052040.97243581
34Nicotine addiction_Homo sapiens_hsa050330.95886711
35Arginine and proline metabolism_Homo sapiens_hsa003300.95738787
36Asthma_Homo sapiens_hsa053100.95660831
37Insulin secretion_Homo sapiens_hsa049110.93255497
38Peroxisome_Homo sapiens_hsa041460.91745683
39Tryptophan metabolism_Homo sapiens_hsa003800.91140725
40Butanoate metabolism_Homo sapiens_hsa006500.86938464
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82614375
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79038622
43Hedgehog signaling pathway_Homo sapiens_hsa043400.77803234
44Metabolic pathways_Homo sapiens_hsa011000.76971495
45One carbon pool by folate_Homo sapiens_hsa006700.76058591
46Retinol metabolism_Homo sapiens_hsa008300.75813479
47Mineral absorption_Homo sapiens_hsa049780.75684183
48Nucleotide excision repair_Homo sapiens_hsa034200.73327936
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.72237242
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72003747
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71552384
52Fanconi anemia pathway_Homo sapiens_hsa034600.70471940
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69089188
54Folate biosynthesis_Homo sapiens_hsa007900.68820231
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.66611907
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64940188
57Base excision repair_Homo sapiens_hsa034100.64627639
58Glycerolipid metabolism_Homo sapiens_hsa005610.64436527
59Basal cell carcinoma_Homo sapiens_hsa052170.64396284
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64273434
61Basal transcription factors_Homo sapiens_hsa030220.64042787
62Propanoate metabolism_Homo sapiens_hsa006400.63022574
63Nitrogen metabolism_Homo sapiens_hsa009100.62393170
64Fatty acid biosynthesis_Homo sapiens_hsa000610.61037138
65Purine metabolism_Homo sapiens_hsa002300.57541192
66Mismatch repair_Homo sapiens_hsa034300.56102714
67Fatty acid metabolism_Homo sapiens_hsa012120.50667527
68Ovarian steroidogenesis_Homo sapiens_hsa049130.50467037
69Sulfur metabolism_Homo sapiens_hsa009200.50432461
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49081443
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.48816868
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48124482
73Morphine addiction_Homo sapiens_hsa050320.47853569
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47106542
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44279739
76Olfactory transduction_Homo sapiens_hsa047400.43816640
77Proteasome_Homo sapiens_hsa030500.43623657
78Pancreatic secretion_Homo sapiens_hsa049720.42847126
79Bile secretion_Homo sapiens_hsa049760.41712614
80DNA replication_Homo sapiens_hsa030300.41580131
81Pyruvate metabolism_Homo sapiens_hsa006200.40138284
82Collecting duct acid secretion_Homo sapiens_hsa049660.39947486
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39514140
84Synaptic vesicle cycle_Homo sapiens_hsa047210.38711915
85Starch and sucrose metabolism_Homo sapiens_hsa005000.38211431
86Serotonergic synapse_Homo sapiens_hsa047260.37543483
87Thyroid hormone synthesis_Homo sapiens_hsa049180.37460250
88Arginine biosynthesis_Homo sapiens_hsa002200.36457015
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.35832256
90Axon guidance_Homo sapiens_hsa043600.32434387
91Glutamatergic synapse_Homo sapiens_hsa047240.31549197
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.30316838
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.28819084
94Glutathione metabolism_Homo sapiens_hsa004800.28133437
95Protein digestion and absorption_Homo sapiens_hsa049740.27931656
96Notch signaling pathway_Homo sapiens_hsa043300.27387383
97beta-Alanine metabolism_Homo sapiens_hsa004100.27356003
98Dopaminergic synapse_Homo sapiens_hsa047280.26790487
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25834704
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25107280

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