RPS2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.15267070
2viral transcription (GO:0019083)8.25049129
3ribosomal small subunit assembly (GO:0000028)8.17271482
4translational termination (GO:0006415)7.92156169
5translational elongation (GO:0006414)6.77882891
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.65778951
7cotranslational protein targeting to membrane (GO:0006613)6.53310609
8protein targeting to ER (GO:0045047)6.49616275
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.23891117
10protein localization to endoplasmic reticulum (GO:0070972)6.10423816
11viral life cycle (GO:0019058)6.06308543
12cellular protein complex disassembly (GO:0043624)6.00329376
13maturation of SSU-rRNA (GO:0030490)5.76491255
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.74511475
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.52053611
16ATP synthesis coupled proton transport (GO:0015986)5.52053611
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.43784835
18ribosomal large subunit biogenesis (GO:0042273)5.41017537
19translational initiation (GO:0006413)5.07632108
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.06947095
21protein complex disassembly (GO:0043241)4.97279497
22ribonucleoprotein complex biogenesis (GO:0022613)4.85253228
23macromolecular complex disassembly (GO:0032984)4.63384422
24cellular component biogenesis (GO:0044085)4.44081602
25chaperone-mediated protein transport (GO:0072321)4.35734293
26protein targeting to membrane (GO:0006612)4.25634084
27protein complex biogenesis (GO:0070271)4.19901534
28ncRNA 3-end processing (GO:0043628)4.19252811
29DNA deamination (GO:0045006)4.15714492
30translation (GO:0006412)4.13574709
31respiratory electron transport chain (GO:0022904)4.10785084
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.07418485
33electron transport chain (GO:0022900)4.07014038
34nuclear-transcribed mRNA catabolic process (GO:0000956)4.06044234
35mRNA catabolic process (GO:0006402)3.84665679
36mitochondrial respiratory chain complex assembly (GO:0033108)3.84600846
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70385875
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.70385875
39NADH dehydrogenase complex assembly (GO:0010257)3.70385875
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59318571
41behavioral response to nicotine (GO:0035095)3.45384502
42RNA catabolic process (GO:0006401)3.43234699
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.42650711
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.40381539
45ATP biosynthetic process (GO:0006754)3.39893499
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32223834
47respiratory chain complex IV assembly (GO:0008535)3.25322136
48rRNA processing (GO:0006364)3.25178198
49ribosome biogenesis (GO:0042254)3.19077225
50rRNA metabolic process (GO:0016072)3.18372940
51positive regulation of prostaglandin secretion (GO:0032308)3.14500240
52termination of RNA polymerase III transcription (GO:0006386)3.14397687
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.14397687
54protein neddylation (GO:0045116)3.10643369
55negative regulation of T cell differentiation in thymus (GO:0033085)3.08631168
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05914332
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04671086
58cytochrome complex assembly (GO:0017004)3.04617349
59pyrimidine nucleotide catabolic process (GO:0006244)3.01264085
60intracellular protein transmembrane import (GO:0044743)2.95737303
61platelet dense granule organization (GO:0060155)2.94124048
62water-soluble vitamin biosynthetic process (GO:0042364)2.93538864
63hydrogen ion transmembrane transport (GO:1902600)2.90157677
64regulation of cellular respiration (GO:0043457)2.85035405
65establishment of protein localization to membrane (GO:0090150)2.82801928
66ubiquinone biosynthetic process (GO:0006744)2.81706008
67protein-cofactor linkage (GO:0018065)2.80854036
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76608474
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76230617
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76230617
71response to interferon-beta (GO:0035456)2.75098499
72cell proliferation in forebrain (GO:0021846)2.74681001
73proton transport (GO:0015992)2.72815778
74protein targeting (GO:0006605)2.72102160
75cellular response to interferon-beta (GO:0035458)2.71576911
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71538850
77protein polyglutamylation (GO:0018095)2.69782473
78hydrogen transport (GO:0006818)2.68985722
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68276095
80protein import into peroxisome matrix (GO:0016558)2.58943465
81forebrain morphogenesis (GO:0048853)2.57919431
82establishment of protein localization to organelle (GO:0072594)2.57766399
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57365269
84positive regulation of T cell apoptotic process (GO:0070234)2.54297842
85positive regulation of fatty acid transport (GO:2000193)2.52169458
86ubiquinone metabolic process (GO:0006743)2.51405438
87phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49550884
88inositol phosphate dephosphorylation (GO:0046855)2.49550884
89replication fork processing (GO:0031297)2.46296546
90regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43527599
91preassembly of GPI anchor in ER membrane (GO:0016254)2.43491887
92resolution of meiotic recombination intermediates (GO:0000712)2.43241634
93GMP metabolic process (GO:0046037)2.40774806
94epithelial cilium movement (GO:0003351)2.38983729
95rhodopsin mediated signaling pathway (GO:0016056)2.38677758
96sequestering of actin monomers (GO:0042989)2.38586256
97mannosylation (GO:0097502)2.37857022
98quinone biosynthetic process (GO:1901663)2.34296137
99negative regulation of telomere maintenance (GO:0032205)2.32757763
100positive regulation of icosanoid secretion (GO:0032305)2.32581019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.51185970
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.95755984
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.23351446
4EZH2_22144423_ChIP-Seq_EOC_Human3.23003059
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05243198
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88807557
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.84215936
8ZNF274_21170338_ChIP-Seq_K562_Hela2.61017419
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58932284
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49810755
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.31836546
12VDR_23849224_ChIP-Seq_CD4+_Human2.05870173
13MYC_18940864_ChIP-ChIP_HL60_Human2.03908231
14VDR_22108803_ChIP-Seq_LS180_Human2.03303242
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88815488
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80922147
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68224069
18FOXP3_21729870_ChIP-Seq_TREG_Human1.63430850
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60383590
20NANOG_20526341_ChIP-Seq_ESCs_Human1.58698216
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58694263
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57558553
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56370833
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55202793
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.55015735
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.51880315
27AR_20517297_ChIP-Seq_VCAP_Human1.47717201
28ELK1_19687146_ChIP-ChIP_HELA_Human1.45807773
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44776748
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44771870
31NCOR_22424771_ChIP-Seq_293T_Human1.44677841
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42574101
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41896310
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37752687
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37746842
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37700220
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.37301852
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36562085
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36346127
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36192850
41XRN2_22483619_ChIP-Seq_HELA_Human1.34840186
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.32548583
43TTF2_22483619_ChIP-Seq_HELA_Human1.32309511
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31820575
45FUS_26573619_Chip-Seq_HEK293_Human1.31797566
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30712187
47IRF1_19129219_ChIP-ChIP_H3396_Human1.30117151
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29592863
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.27340724
50HTT_18923047_ChIP-ChIP_STHdh_Human1.26922907
51BCL6_27268052_Chip-Seq_Bcells_Human1.26600183
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.26285483
53TP53_22573176_ChIP-Seq_HFKS_Human1.26147198
54TAF2_19829295_ChIP-Seq_ESCs_Human1.25542392
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25292102
56ERA_21632823_ChIP-Seq_H3396_Human1.24505294
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24104449
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23478433
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23424741
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.22670915
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22529906
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.22258392
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22258392
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.22144336
65CBP_20019798_ChIP-Seq_JUKART_Human1.21163825
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21163825
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20935424
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19199748
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.17149421
70EWS_26573619_Chip-Seq_HEK293_Human1.15473404
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.14772317
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14083770
73ERG_20517297_ChIP-Seq_VCAP_Human1.13474726
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12214747
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11977824
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.09837246
77P300_27268052_Chip-Seq_Bcells_Human1.09499963
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07260605
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07091487
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04452815
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.02333575
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01079057
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00829649
84P53_21459846_ChIP-Seq_SAOS-2_Human1.00146020
85ER_23166858_ChIP-Seq_MCF-7_Human1.00046712
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99317007
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99215893
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.99201575
89GABP_19822575_ChIP-Seq_HepG2_Human0.99000093
90THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98033902
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97402939
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.95766027
93MYC_19829295_ChIP-Seq_ESCs_Human0.94440006
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94392289
95SA1_27219007_Chip-Seq_Bcells_Human0.94347144
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94302379
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94051137
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93580575
99RAC3_21632823_ChIP-Seq_H3396_Human0.93569719
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89951666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.24458008
2MP0006292_abnormal_olfactory_placode4.61308481
3MP0002837_dystrophic_cardiac_calcinosis3.34467579
4MP0002163_abnormal_gland_morphology2.88775811
5MP0002653_abnormal_ependyma_morphology2.67805715
6MP0005075_abnormal_melanosome_morpholog2.53055202
7MP0004147_increased_porphyrin_level2.48687230
8MP0001873_stomach_inflammation2.39918119
9MP0005671_abnormal_response_to2.29171877
10MP0001986_abnormal_taste_sensitivity2.06394818
11MP0003787_abnormal_imprinting1.99890489
12MP0005379_endocrine/exocrine_gland_phen1.99682689
13MP0008875_abnormal_xenobiotic_pharmacok1.82758889
14MP0008872_abnormal_physiological_respon1.78639562
15MP0002638_abnormal_pupillary_reflex1.76473720
16MP0005646_abnormal_pituitary_gland1.74544046
17MP0003121_genomic_imprinting1.74535171
18MP0003646_muscle_fatigue1.71286640
19MP0003879_abnormal_hair_cell1.67625306
20MP0001968_abnormal_touch/_nociception1.65254508
21MP0005377_hearing/vestibular/ear_phenot1.62635996
22MP0003878_abnormal_ear_physiology1.62635996
23MP0009333_abnormal_splenocyte_physiolog1.61683555
24MP0003195_calcinosis1.60704499
25MP0005174_abnormal_tail_pigmentation1.59138246
26MP0002095_abnormal_skin_pigmentation1.57057671
27MP0004885_abnormal_endolymph1.52151057
28MP0004142_abnormal_muscle_tone1.51496637
29MP0005551_abnormal_eye_electrophysiolog1.50583798
30MP0005389_reproductive_system_phenotype1.49264022
31MP0006082_CNS_inflammation1.47400162
32MP0001835_abnormal_antigen_presentation1.44239273
33MP0002160_abnormal_reproductive_system1.44042827
34MP0002736_abnormal_nociception_after1.39679179
35MP0000685_abnormal_immune_system1.38443343
36MP0000372_irregular_coat_pigmentation1.37958733
37MP0001919_abnormal_reproductive_system1.37374905
38MP0000631_abnormal_neuroendocrine_gland1.31944353
39MP0008775_abnormal_heart_ventricle1.31838713
40MP0001905_abnormal_dopamine_level1.30939530
41MP0001800_abnormal_humoral_immune1.30340216
42MP0001764_abnormal_homeostasis1.29334696
43MP0001293_anophthalmia1.25624246
44MP0002938_white_spotting1.24137139
45MP0005423_abnormal_somatic_nervous1.23843839
46MP0002234_abnormal_pharynx_morphology1.23041195
47MP0009785_altered_susceptibility_to1.22898610
48MP0004145_abnormal_muscle_electrophysio1.22808480
49MP0003186_abnormal_redox_activity1.20939573
50MP0002102_abnormal_ear_morphology1.20849593
51MP0008877_abnormal_DNA_methylation1.20725934
52MP0006276_abnormal_autonomic_nervous1.19660671
53MP0003136_yellow_coat_color1.17732108
54MP0006072_abnormal_retinal_apoptosis1.14130651
55MP0005084_abnormal_gallbladder_morpholo1.14067046
56MP0003283_abnormal_digestive_organ1.10671834
57MP0004510_myositis1.10185304
58MP0002138_abnormal_hepatobiliary_system1.05946411
59MP0003880_abnormal_central_pattern1.05094769
60MP0004742_abnormal_vestibular_system1.04547846
61MP0002933_joint_inflammation1.03671937
62MP0005645_abnormal_hypothalamus_physiol1.02523249
63MP0008789_abnormal_olfactory_epithelium0.99402313
64MP0001663_abnormal_digestive_system0.97642674
65MP0000049_abnormal_middle_ear0.94475591
66MP0002148_abnormal_hypersensitivity_rea0.92762914
67MP0003763_abnormal_thymus_physiology0.90214660
68MP0002272_abnormal_nervous_system0.88640958
69MP0002723_abnormal_immune_serum0.88038501
70MP0002277_abnormal_respiratory_mucosa0.86198823
71MP0005410_abnormal_fertilization0.84694517
72MP0002693_abnormal_pancreas_physiology0.84416904
73MP0000026_abnormal_inner_ear0.84094433
74MP0003011_delayed_dark_adaptation0.83361174
75MP0002006_tumorigenesis0.81817910
76MP0003122_maternal_imprinting0.81574381
77MP0000678_abnormal_parathyroid_gland0.80350626
78MP0005195_abnormal_posterior_eye0.78599063
79MP0003123_paternal_imprinting0.78032457
80MP0005000_abnormal_immune_tolerance0.77961778
81MP0002420_abnormal_adaptive_immunity0.77667087
82MP0001963_abnormal_hearing_physiology0.76723438
83MP0001790_abnormal_immune_system0.76238288
84MP0005387_immune_system_phenotype0.76238288
85MP0001819_abnormal_immune_cell0.74986246
86MP0005253_abnormal_eye_physiology0.74820568
87MP0009745_abnormal_behavioral_response0.74757108
88MP0004134_abnormal_chest_morphology0.74597330
89MP0001727_abnormal_embryo_implantation0.72999314
90MP0002166_altered_tumor_susceptibility0.72688629
91MP0001485_abnormal_pinna_reflex0.72470358
92MP0005408_hypopigmentation0.72460220
93MP0005448_abnormal_energy_balance0.72200413
94MP0003866_abnormal_defecation0.70512390
95MP0002876_abnormal_thyroid_physiology0.68646802
96MP0002733_abnormal_thermal_nociception0.67988593
97MP0000703_abnormal_thymus_morphology0.66032232
98MP0002210_abnormal_sex_determination0.65949874
99MP0002452_abnormal_antigen_presenting0.65923086
100MP0001286_abnormal_eye_development0.65777277

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.95425730
2Acute necrotizing encephalopathy (HP:0006965)4.27693676
3Abnormality of cells of the erythroid lineage (HP:0012130)4.18386332
4Constricted visual fields (HP:0001133)4.18228828
5Mitochondrial inheritance (HP:0001427)4.10504204
6Attenuation of retinal blood vessels (HP:0007843)4.03901427
7Increased hepatocellular lipid droplets (HP:0006565)3.96239780
8Abnormal mitochondria in muscle tissue (HP:0008316)3.96206923
9Abnormal number of erythroid precursors (HP:0012131)3.81551708
10Lipid accumulation in hepatocytes (HP:0006561)3.73913542
11Increased CSF lactate (HP:0002490)3.65197039
12Abnormality of macular pigmentation (HP:0008002)3.64321221
13Acute encephalopathy (HP:0006846)3.59029473
14Progressive macrocephaly (HP:0004481)3.58779028
15Renal Fanconi syndrome (HP:0001994)3.52631114
16Macrocytic anemia (HP:0001972)3.42269291
17Optic disc pallor (HP:0000543)3.33144939
18Chronic hepatic failure (HP:0100626)3.20574915
19Type II lissencephaly (HP:0007260)3.17821828
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.14035554
21Hepatocellular necrosis (HP:0001404)3.06363722
22Absent/shortened dynein arms (HP:0200106)3.04314191
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.04314191
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.01601774
25Increased intramyocellular lipid droplets (HP:0012240)2.97822954
26Congenital stationary night blindness (HP:0007642)2.90239508
27Cerebral edema (HP:0002181)2.88067367
28Abnormal rod and cone electroretinograms (HP:0008323)2.85987906
29Pallor (HP:0000980)2.73702501
30Absent thumb (HP:0009777)2.70079119
31Abnormality of midbrain morphology (HP:0002418)2.68189477
32Molar tooth sign on MRI (HP:0002419)2.68189477
33Exertional dyspnea (HP:0002875)2.67915033
34Hepatic necrosis (HP:0002605)2.64293308
35Increased muscle lipid content (HP:0009058)2.58761412
36Pancreatic cysts (HP:0001737)2.55639498
37Pancreatic fibrosis (HP:0100732)2.52721603
38Abnormal respiratory epithelium morphology (HP:0012253)2.46844837
39Abnormal respiratory motile cilium morphology (HP:0005938)2.46844837
403-Methylglutaconic aciduria (HP:0003535)2.42734043
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38261119
42Increased serum lactate (HP:0002151)2.37454746
43True hermaphroditism (HP:0010459)2.32936804
44Elevated erythrocyte sedimentation rate (HP:0003565)2.31169909
45Abnormality of DNA repair (HP:0003254)2.30721014
46Septo-optic dysplasia (HP:0100842)2.29350947
47Congenital, generalized hypertrichosis (HP:0004540)2.28506754
48Lactic acidosis (HP:0003128)2.28130397
49Abnormal ciliary motility (HP:0012262)2.26647819
50Pendular nystagmus (HP:0012043)2.26412983
51IgG deficiency (HP:0004315)2.26407888
52Cerebellar dysplasia (HP:0007033)2.25125230
53Abnormality of renal resorption (HP:0011038)2.22654187
54Aplasia/hypoplasia of the uterus (HP:0008684)2.13859838
55Abnormal respiratory motile cilium physiology (HP:0012261)2.11460059
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.11225077
57Respiratory difficulties (HP:0002880)2.11099958
58Sclerocornea (HP:0000647)2.10891510
59Nephronophthisis (HP:0000090)2.06518351
60Brushfield spots (HP:0001088)2.04094614
61Glycosuria (HP:0003076)2.04022523
62Abnormality of urine glucose concentration (HP:0011016)2.04022523
63Round ear (HP:0100830)1.99667339
64Asplenia (HP:0001746)1.98999851
65Abolished electroretinogram (ERG) (HP:0000550)1.97632562
66Hyperphosphaturia (HP:0003109)1.96479418
67Abnormality of the labia minora (HP:0012880)1.94489808
68Volvulus (HP:0002580)1.92916203
69Lethargy (HP:0001254)1.92208736
70Severe muscular hypotonia (HP:0006829)1.87878738
71Decreased central vision (HP:0007663)1.86287886
72Optic nerve hypoplasia (HP:0000609)1.85624084
73Exercise intolerance (HP:0003546)1.82445092
74Pancytopenia (HP:0001876)1.80511894
75Colon cancer (HP:0003003)1.80264309
76Rhinitis (HP:0012384)1.79562483
77Respiratory failure (HP:0002878)1.79507445
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77953307
79Retinal dysplasia (HP:0007973)1.75427546
80Methylmalonic acidemia (HP:0002912)1.75418984
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74075657
82Hypoplasia of the uterus (HP:0000013)1.73308398
83Striae distensae (HP:0001065)1.72484253
84Cupped ribs (HP:0000887)1.71194863
85Methylmalonic aciduria (HP:0012120)1.71110683
86Concave nail (HP:0001598)1.69410545
87Type 2 muscle fiber atrophy (HP:0003554)1.68898218
88Abnormal hemoglobin (HP:0011902)1.68123741
89Triphalangeal thumb (HP:0001199)1.67469808
90Metaphyseal cupping (HP:0003021)1.67456453
91Leukodystrophy (HP:0002415)1.66503674
92Hypoplasia of the radius (HP:0002984)1.65766408
93Abnormality of the renal medulla (HP:0100957)1.64242472
94Ketosis (HP:0001946)1.64239142
95Bony spicule pigmentary retinopathy (HP:0007737)1.62711598
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61073008
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61073008
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.59796876
99Hyperglycinemia (HP:0002154)1.59729993
100Myositis (HP:0100614)1.58621675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.86529445
2PASK3.68012448
3TXK3.48076020
4VRK22.90078788
5TLK12.83268074
6NUAK12.66330834
7BCKDK2.47029671
8ADRBK22.46557102
9MAP4K22.44106982
10CDK192.42377262
11MUSK2.34030877
12FES2.19973699
13TEC1.99547227
14FRK1.97018002
15TESK21.95869064
16GRK11.95485174
17MAP4K11.88480096
18ZAK1.79989900
19STK161.79967244
20KDR1.75099023
21DYRK21.70504980
22WNK31.57802836
23SIK21.54962695
24IKBKB1.51837218
25VRK11.49574616
26NEK21.34905788
27NME11.33927081
28WNK41.28260703
29MAP3K131.20476668
30SYK1.20321909
31MAP3K121.18941658
32ACVR1B1.18301044
33IKBKE1.17141977
34TYRO31.16583716
35CAMKK11.12882712
36ITK1.10267627
37INSRR1.03958241
38BTK1.03704457
39PRKCQ1.02375295
40NME21.01186466
41ADRBK10.97510706
42BMPR1B0.97134510
43JAK30.87332090
44LCK0.87006452
45GRK70.86285326
46LRRK20.84846673
47TAOK30.84607918
48LIMK10.82738716
49OXSR10.79821996
50CDC70.79781907
51TIE10.79498904
52MKNK10.75664205
53MKNK20.75035804
54RPS6KB20.71841576
55PINK10.71278694
56MAP3K110.71082865
57MAP2K70.70358726
58TAF10.70197739
59MAP2K20.65195952
60PRKCG0.65167441
61PIK3CA0.64800313
62CSK0.62680842
63CSNK1G20.60977733
64GRK50.60064667
65LYN0.55459412
66GRK60.53434241
67MAPK150.53398107
68FLT30.53147851
69CAMKK20.52354979
70PLK40.52045450
71MAP3K40.52011915
72RPS6KA50.51818601
73TESK10.50516445
74MAPK130.50205919
75STK390.50170904
76CSNK1G30.49639354
77TNK20.47670685
78OBSCN0.46292597
79CSF1R0.44674136
80TBK10.42091430
81PRKACA0.41648624
82MATK0.41180699
83ABL20.40586545
84BRAF0.40446727
85PRKCA0.40222127
86DAPK30.39960721
87TGFBR10.38029374
88CSNK1G10.37570245
89MAPKAPK50.37406164
90CSNK2A20.36866506
91MAP2K60.36263231
92RIPK40.35255034
93PRKCD0.34568834
94DAPK10.33129889
95PIK3CG0.31644692
96ARAF0.31613513
97ATR0.31184428
98PHKG20.31124284
99PHKG10.31124284
100AURKA0.30599831

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.66473713
2Oxidative phosphorylation_Homo sapiens_hsa001904.40835856
3Parkinsons disease_Homo sapiens_hsa050123.62346284
4Proteasome_Homo sapiens_hsa030502.80519229
5RNA polymerase_Homo sapiens_hsa030202.49029222
6Huntingtons disease_Homo sapiens_hsa050162.38125016
7Alzheimers disease_Homo sapiens_hsa050102.37124722
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36912457
9Phototransduction_Homo sapiens_hsa047442.10735774
10Primary immunodeficiency_Homo sapiens_hsa053402.00404607
11Homologous recombination_Homo sapiens_hsa034401.98399843
12Asthma_Homo sapiens_hsa053101.86194151
13Cardiac muscle contraction_Homo sapiens_hsa042601.85510284
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.74341281
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73105458
16Caffeine metabolism_Homo sapiens_hsa002321.69168718
17Linoleic acid metabolism_Homo sapiens_hsa005911.67127681
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67023269
19Allograft rejection_Homo sapiens_hsa053301.51022366
20Nitrogen metabolism_Homo sapiens_hsa009101.48892237
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45746698
22Autoimmune thyroid disease_Homo sapiens_hsa053201.40727887
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38333655
24Graft-versus-host disease_Homo sapiens_hsa053321.30924587
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30393751
26Pyrimidine metabolism_Homo sapiens_hsa002401.28575796
27Fanconi anemia pathway_Homo sapiens_hsa034601.25790497
28Mismatch repair_Homo sapiens_hsa034301.20886923
29RNA degradation_Homo sapiens_hsa030181.17077393
30Peroxisome_Homo sapiens_hsa041461.17006627
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11486762
32Protein export_Homo sapiens_hsa030601.09788935
33Arachidonic acid metabolism_Homo sapiens_hsa005901.07583244
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04788069
35Purine metabolism_Homo sapiens_hsa002301.04372510
36Tryptophan metabolism_Homo sapiens_hsa003801.04363024
37Type I diabetes mellitus_Homo sapiens_hsa049401.00122853
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99244915
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98705074
40One carbon pool by folate_Homo sapiens_hsa006700.98443881
41Basal transcription factors_Homo sapiens_hsa030220.95683174
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93559490
43Antigen processing and presentation_Homo sapiens_hsa046120.93094898
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92331982
45Nucleotide excision repair_Homo sapiens_hsa034200.91086944
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90476801
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89698780
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.88817749
49Base excision repair_Homo sapiens_hsa034100.88690176
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.86022312
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83963976
52Hematopoietic cell lineage_Homo sapiens_hsa046400.81852246
53Olfactory transduction_Homo sapiens_hsa047400.81217290
54Sulfur metabolism_Homo sapiens_hsa009200.80157567
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79799662
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77074748
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75197128
58Propanoate metabolism_Homo sapiens_hsa006400.73219082
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.71246040
60DNA replication_Homo sapiens_hsa030300.70105505
61Fat digestion and absorption_Homo sapiens_hsa049750.69109145
62Metabolic pathways_Homo sapiens_hsa011000.67998488
63Chemical carcinogenesis_Homo sapiens_hsa052040.67703953
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.66958155
65Nicotine addiction_Homo sapiens_hsa050330.63487202
66beta-Alanine metabolism_Homo sapiens_hsa004100.62985516
67Retinol metabolism_Homo sapiens_hsa008300.61979534
68Butanoate metabolism_Homo sapiens_hsa006500.61115814
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60962305
70Sulfur relay system_Homo sapiens_hsa041220.56359340
71Rheumatoid arthritis_Homo sapiens_hsa053230.55283732
72Spliceosome_Homo sapiens_hsa030400.54839744
73Folate biosynthesis_Homo sapiens_hsa007900.54814755
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54789216
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54170418
76Tyrosine metabolism_Homo sapiens_hsa003500.53851901
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51262069
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46419930
79Morphine addiction_Homo sapiens_hsa050320.44413393
80T cell receptor signaling pathway_Homo sapiens_hsa046600.42010144
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41851028
82Ether lipid metabolism_Homo sapiens_hsa005650.38904895
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38140558
84Fatty acid degradation_Homo sapiens_hsa000710.38133097
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.38092559
86Basal cell carcinoma_Homo sapiens_hsa052170.37160983
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33901112
88Taste transduction_Homo sapiens_hsa047420.33879691
89Glutathione metabolism_Homo sapiens_hsa004800.33304308
90Regulation of autophagy_Homo sapiens_hsa041400.31960122
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30586647
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.30308722
93Glycerolipid metabolism_Homo sapiens_hsa005610.29565149
94Vitamin digestion and absorption_Homo sapiens_hsa049770.26860687
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25615615
96Systemic lupus erythematosus_Homo sapiens_hsa053220.24752375
97Hedgehog signaling pathway_Homo sapiens_hsa043400.24578595
98Selenocompound metabolism_Homo sapiens_hsa004500.23810792
99RNA transport_Homo sapiens_hsa030130.23796825
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23443247

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