RPS2P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)9.55442417
2regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)9.55442417
3positive regulation of megakaryocyte differentiation (GO:0045654)8.62934765
4endothelial cell morphogenesis (GO:0001886)8.01940305
5regulation of mesenchymal cell apoptotic process (GO:2001053)7.96372321
6positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)7.50147591
7negative regulation of fibroblast apoptotic process (GO:2000270)6.76824207
8prostate gland epithelium morphogenesis (GO:0060740)6.66564217
9natural killer cell activation involved in immune response (GO:0002323)6.48449601
10negative regulation of epidermal cell differentiation (GO:0045605)6.35160707
11regulation of MHC class I biosynthetic process (GO:0045343)6.30242360
12negative regulation of mRNA splicing, via spliceosome (GO:0048025)6.15191258
13alternative mRNA splicing, via spliceosome (GO:0000380)5.99728747
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.89835366
15ventricular septum development (GO:0003281)5.84383415
16male genitalia development (GO:0030539)5.55145716
17negative regulation of mRNA processing (GO:0050686)5.48600608
18detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.48068216
19regulation of mitotic spindle organization (GO:0060236)5.32131152
20bone trabecula formation (GO:0060346)5.15392016
21negative regulation of epidermis development (GO:0045683)5.13407977
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.12273126
23embryonic forelimb morphogenesis (GO:0035115)5.11610011
24blood vessel maturation (GO:0001955)5.07093494
25ER overload response (GO:0006983)5.05964426
26regulation of translational termination (GO:0006449)4.75556139
27negative regulation of RNA splicing (GO:0033119)4.71303564
28nuclear pore organization (GO:0006999)4.67858545
29generation of neurons (GO:0048699)4.56205757
30detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.54157840
31rRNA catabolic process (GO:0016075)4.52138383
32negative regulation of mRNA metabolic process (GO:1903312)4.50896480
33reproductive system development (GO:0061458)4.39681371
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39558236
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.39558236
36NADH dehydrogenase complex assembly (GO:0010257)4.39558236
37negative regulation of DNA repair (GO:0045738)4.37881170
38regulation of keratinocyte proliferation (GO:0010837)4.34228955
39negative regulation of osteoblast proliferation (GO:0033689)4.22420247
40forelimb morphogenesis (GO:0035136)4.22165777
41positive regulation of actin cytoskeleton reorganization (GO:2000251)4.12274420
42myoblast migration (GO:0051451)4.02561680
43cardiac septum development (GO:0003279)4.01712419
44natural killer cell differentiation (GO:0001779)4.01671951
45embryonic process involved in female pregnancy (GO:0060136)4.01099400
46regulation of DNA damage checkpoint (GO:2000001)3.92352933
47positive regulation of erythrocyte differentiation (GO:0045648)3.91406212
48regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.89439537
49positive regulation of developmental pigmentation (GO:0048087)3.88537776
50regulation of fibroblast apoptotic process (GO:2000269)3.86320359
51hematopoietic stem cell differentiation (GO:0060218)3.81925363
52monoubiquitinated protein deubiquitination (GO:0035520)3.81375407
53lateral ventricle development (GO:0021670)3.79189939
54cellular response to vitamin D (GO:0071305)3.78265191
55regulation of megakaryocyte differentiation (GO:0045652)3.70320707
56anatomical structure regression (GO:0060033)3.69118080
57head development (GO:0060322)3.68518025
58regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.61379354
59metanephric mesenchyme development (GO:0072075)3.56530415
60regulation of double-strand break repair via homologous recombination (GO:0010569)3.52710817
61granulocyte differentiation (GO:0030851)3.50920623
62definitive hemopoiesis (GO:0060216)3.48948415
63embryonic camera-type eye morphogenesis (GO:0048596)3.38416249
64genitalia development (GO:0048806)3.34969406
65lateral sprouting from an epithelium (GO:0060601)3.33301891
66natural killer cell activation (GO:0030101)3.32542941
67regulation of spindle organization (GO:0090224)3.30260099
68enteric nervous system development (GO:0048484)3.29008023
69negative regulation of myoblast differentiation (GO:0045662)3.26289551
70protein complex biogenesis (GO:0070271)3.19976739
71female gonad development (GO:0008585)3.18928491
72negative regulation of circadian rhythm (GO:0042754)3.18518757
73mechanoreceptor differentiation (GO:0042490)3.15367828
74negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.15027026
75negative regulation of androgen receptor signaling pathway (GO:0060766)3.14439897
76response to exogenous dsRNA (GO:0043330)3.13571361
77short-chain fatty acid metabolic process (GO:0046459)3.09739935
78viral mRNA export from host cell nucleus (GO:0046784)3.09049633
79transcription elongation from RNA polymerase I promoter (GO:0006362)3.08423031
80purine deoxyribonucleotide catabolic process (GO:0009155)3.06832528
81hindbrain development (GO:0030902)3.06562584
82respiratory chain complex IV assembly (GO:0008535)3.04333852
83nuclear pore complex assembly (GO:0051292)3.02214008
84mesenchymal cell development (GO:0014031)3.01138725
85regulation of non-canonical Wnt signaling pathway (GO:2000050)3.00924033
86kidney mesenchyme development (GO:0072074)3.00887742
87CENP-A containing nucleosome assembly (GO:0034080)2.99084389
88negative regulation of bone remodeling (GO:0046851)2.97337255
89embryonic appendage morphogenesis (GO:0035113)2.96770759
90embryonic limb morphogenesis (GO:0030326)2.96770759
91mRNA splice site selection (GO:0006376)2.94504031
92regulation of mRNA splicing, via spliceosome (GO:0048024)2.93504685
93glucose 6-phosphate metabolic process (GO:0051156)2.86378960
94termination of RNA polymerase I transcription (GO:0006363)2.85977584
95regulation of double-strand break repair (GO:2000779)2.84073337
96mitochondrial respiratory chain complex assembly (GO:0033108)2.83018382
97regulation of keratinocyte differentiation (GO:0045616)2.81824432
98chromatin remodeling at centromere (GO:0031055)2.79830604
99positive regulation of mitosis (GO:0045840)2.78503817
100branching involved in prostate gland morphogenesis (GO:0060442)12.3813623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.21612353
2CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.06087837
3FUS_26573619_Chip-Seq_HEK293_Human3.88543153
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84950811
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58078855
6ZNF274_21170338_ChIP-Seq_K562_Hela3.47704604
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.93428043
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.90968543
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.89967353
10EWS_26573619_Chip-Seq_HEK293_Human2.85472545
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56563760
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.44398945
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39959625
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.38637239
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34181883
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29392426
17TAF15_26573619_Chip-Seq_HEK293_Human2.17058999
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09937991
19ELK1_19687146_ChIP-ChIP_HELA_Human2.04189097
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99767556
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93689713
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91555819
23P300_19829295_ChIP-Seq_ESCs_Human1.90499966
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89666216
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85713013
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84254491
27IGF1R_20145208_ChIP-Seq_DFB_Human1.76585263
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75484178
29VDR_22108803_ChIP-Seq_LS180_Human1.72414051
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67026860
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62125558
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61196593
33GBX2_23144817_ChIP-Seq_PC3_Human1.53868135
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53329759
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.50537065
36TP53_22573176_ChIP-Seq_HFKS_Human1.49637261
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.46767547
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46435922
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35860938
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34069740
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.32849143
42RNF2_27304074_Chip-Seq_NSC_Mouse1.31574783
43FLI1_21867929_ChIP-Seq_TH2_Mouse1.31360518
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30880371
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29421582
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29421582
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28113582
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28113582
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28113582
50SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.27544791
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26575866
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26038628
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26038628
54MYC_18940864_ChIP-ChIP_HL60_Human1.24180386
55SMAD4_21799915_ChIP-Seq_A2780_Human1.23337998
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22986216
57E2F7_22180533_ChIP-Seq_HELA_Human1.21846910
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.20172130
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19920670
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19755163
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19252075
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18608184
63ZNF263_19887448_ChIP-Seq_K562_Human1.18284866
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15907547
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14930042
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14520100
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.14285618
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12868623
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.11974209
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10912733
71CDX2_22108803_ChIP-Seq_LS180_Human1.10449182
72VDR_23849224_ChIP-Seq_CD4+_Human1.09659577
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05964654
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03742396
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03520798
76SOX9_26525672_Chip-Seq_HEART_Mouse1.03043091
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02546504
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02241592
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02238486
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02182756
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02096949
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01983096
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.01884483
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00408802
85TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99579973
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.98719242
87BCAT_22108803_ChIP-Seq_LS180_Human0.98685688
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98470174
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97816595
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95777821
91TTF2_22483619_ChIP-Seq_HELA_Human0.95101183
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.95043149
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94570036
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93745058
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.92622614
96ETS1_20019798_ChIP-Seq_JURKAT_Human0.92492419
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91588673
98GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91347488
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91046872
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90334530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology7.95485593
2MP0000516_abnormal_urinary_system7.01221763
3MP0005367_renal/urinary_system_phenotyp7.01221763
4MP0003315_abnormal_perineum_morphology6.59464643
5MP0005187_abnormal_penis_morphology5.43459735
6MP0010030_abnormal_orbit_morphology3.88289255
7MP0005645_abnormal_hypothalamus_physiol3.59851317
8MP0003136_yellow_coat_color3.41287522
9MP0002938_white_spotting2.91482209
10MP0000538_abnormal_urinary_bladder2.73640194
11MP0003937_abnormal_limbs/digits/tail_de2.59485360
12MP0002254_reproductive_system_inflammat2.45318224
13MP0008877_abnormal_DNA_methylation2.03883875
14MP0001346_abnormal_lacrimal_gland2.01435839
15MP0005075_abnormal_melanosome_morpholog1.98095965
16MP0002396_abnormal_hematopoietic_system1.97360638
17MP0009250_abnormal_appendicular_skeleto1.81071815
18MP0001502_abnormal_circadian_rhythm1.60045232
19MP0003385_abnormal_body_wall1.54120300
20MP0003942_abnormal_urinary_system1.53089369
21MP0003828_pulmonary_edema1.49892086
22MP0002090_abnormal_vision1.49389320
23MP0004381_abnormal_hair_follicle1.45286682
24MP0005197_abnormal_uvea_morphology1.39633271
25MP0001293_anophthalmia1.35711534
26MP0008995_early_reproductive_senescence1.35366207
27MP0003122_maternal_imprinting1.33553334
28MP0001664_abnormal_digestion1.17148584
29MP0002751_abnormal_autonomic_nervous1.10317480
30MP0005084_abnormal_gallbladder_morpholo1.07948224
31MP0002109_abnormal_limb_morphology1.07046721
32MP0009703_decreased_birth_body0.98080955
33MP0003121_genomic_imprinting0.97276503
34MP0002638_abnormal_pupillary_reflex0.96764329
35MP0003938_abnormal_ear_development0.94089338
36MP0009780_abnormal_chondrocyte_physiolo0.92333683
37MP0000613_abnormal_salivary_gland0.91020824
38MP0006035_abnormal_mitochondrial_morpho0.91018638
39MP0002115_abnormal_skeleton_extremities0.90142531
40MP0002233_abnormal_nose_morphology0.89692975
41MP0008058_abnormal_DNA_repair0.88742444
42MP0002138_abnormal_hepatobiliary_system0.88194432
43MP0000428_abnormal_craniofacial_morphol0.87795690
44MP0002928_abnormal_bile_duct0.85794687
45MP0002139_abnormal_hepatobiliary_system0.83836789
46MP0009697_abnormal_copulation0.82261896
47MP0003935_abnormal_craniofacial_develop0.82033564
48MP0003868_abnormal_feces_composition0.78353335
49MP0003646_muscle_fatigue0.77346263
50MP0001485_abnormal_pinna_reflex0.72649986
51MP0002095_abnormal_skin_pigmentation0.71129225
52MP0003755_abnormal_palate_morphology0.69860453
53MP0000049_abnormal_middle_ear0.69760048
54MP0002108_abnormal_muscle_morphology0.69263275
55MP0001340_abnormal_eyelid_morphology0.66917274
56MP0008007_abnormal_cellular_replicative0.66706867
57MP0010094_abnormal_chromosome_stability0.66649845
58MP0004133_heterotaxia0.65577275
59MP0003111_abnormal_nucleus_morphology0.64694744
60MP0005310_abnormal_salivary_gland0.62285752
61MP0001119_abnormal_female_reproductive0.60728378
62MP0000432_abnormal_head_morphology0.59838362
63MP0002127_abnormal_cardiovascular_syste0.57512661
64MP0001145_abnormal_male_reproductive0.56337236
65MP0002116_abnormal_craniofacial_bone0.54965526
66MP0002269_muscular_atrophy0.52957473
67MP0002086_abnormal_extraembryonic_tissu0.49643946
68MP0005248_abnormal_Harderian_gland0.49199590
69MP0002177_abnormal_outer_ear0.48398957
70MP0003786_premature_aging0.47332296
71MP0001697_abnormal_embryo_size0.46871492
72MP0001873_stomach_inflammation0.46833911
73MP0000653_abnormal_sex_gland0.46121319
74MP0002295_abnormal_pulmonary_circulatio0.44373554
75MP0002114_abnormal_axial_skeleton0.42810740
76MP0009672_abnormal_birth_weight0.39296800
77MP0010352_gastrointestinal_tract_polyps0.39003081
78MP0003861_abnormal_nervous_system0.37699496
79MP0001784_abnormal_fluid_regulation0.37247157
80MP0003077_abnormal_cell_cycle0.35455547
81MP0002085_abnormal_embryonic_tissue0.35210574
82MP0002282_abnormal_trachea_morphology0.35018515
83MP0001299_abnormal_eye_distance/0.34895334
84MP0002102_abnormal_ear_morphology0.33654945
85MP0000749_muscle_degeneration0.32895025
86MP0002084_abnormal_developmental_patter0.32019342
87MP0000266_abnormal_heart_morphology0.31382700
88MP0003943_abnormal_hepatobiliary_system0.30833956
89MP0005220_abnormal_exocrine_pancreas0.30626748
90MP0003698_abnormal_male_reproductive0.29849299
91MP0003787_abnormal_imprinting0.29503554
92MP0000639_abnormal_adrenal_gland0.29068496
93MP0002135_abnormal_kidney_morphology0.28780877
94MP0006072_abnormal_retinal_apoptosis0.28145568
95MP0001286_abnormal_eye_development0.28114457
96MP0002069_abnormal_eating/drinking_beha0.27591780
97MP0002210_abnormal_sex_determination0.27554150
98MP0000778_abnormal_nervous_system0.26442370
99MP0001929_abnormal_gametogenesis0.26426248
100MP0002736_abnormal_nociception_after0.26402273

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)8.97454833
2Short 1st metacarpal (HP:0010034)8.97454833
3Septate vagina (HP:0001153)8.92418887
4Abnormal tarsal ossification (HP:0008369)8.42939294
5Abnormality of the 1st metacarpal (HP:0010009)7.93713487
6Spontaneous abortion (HP:0005268)7.02177098
73-Methylglutaconic aciduria (HP:0003535)6.64389016
8Abnormality of the 2nd finger (HP:0004100)6.55182954
9Abnormal foot bone ossification (HP:0010675)6.22527979
10Short phalanx of the thumb (HP:0009660)5.81405479
11Ureteral stenosis (HP:0000071)5.49644247
12Unilateral renal agenesis (HP:0000122)5.32646184
13Ureteral obstruction (HP:0006000)5.07852716
14Short 5th finger (HP:0009237)4.95886105
15Short hallux (HP:0010109)4.89532006
16Septo-optic dysplasia (HP:0100842)4.79571796
17Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.63259942
18Aplasia/Hypoplasia of the 5th finger (HP:0006262)4.57933105
19Aplasia/Hypoplasia of the hallux (HP:0008362)4.55721466
20Abnormality of the musculature of the hand (HP:0001421)4.16735955
21Abnormality of carpal bone ossification (HP:0006257)4.10935119
22Absent eyebrow (HP:0002223)3.60958000
23Midline defect of the nose (HP:0004122)3.53508830
24Flat capital femoral epiphysis (HP:0003370)3.52713808
25Abnormal hand bone ossification (HP:0010660)3.31373403
26Short middle phalanx of finger (HP:0005819)3.23128357
27Synostosis of carpal bones (HP:0005048)3.07412445
28Abnormal ossification of hand bones (HP:0005921)3.06510570
29Deviation of the hallux (HP:0010051)3.05248723
30Popliteal pterygium (HP:0009756)3.04229174
31Sacral dimple (HP:0000960)2.94577296
32Proximal placement of thumb (HP:0009623)2.91590218
33Bifid scrotum (HP:0000048)2.84626543
34Shawl scrotum (HP:0000049)2.74496791
35Cleft eyelid (HP:0000625)2.70100843
36Late onset (HP:0003584)2.69538758
37Optic nerve hypoplasia (HP:0000609)2.68824501
38Methylmalonic acidemia (HP:0002912)2.66770429
39Deviation of the thumb (HP:0009603)2.64793325
40Elfin facies (HP:0004428)2.62883884
41Overriding aorta (HP:0002623)2.61603910
42Chronic hepatic failure (HP:0100626)2.48914655
43Maternal diabetes (HP:0009800)2.38743164
44Facial cleft (HP:0002006)2.38139260
45Absent septum pellucidum (HP:0001331)2.37870816
46Flat cornea (HP:0007720)2.33117833
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31904907
48Difficulty running (HP:0009046)2.30152003
49Carpal synostosis (HP:0009702)2.25854262
50Colon cancer (HP:0003003)2.25632088
51Dyschromatopsia (HP:0007641)2.25031976
52Ulnar deviation of finger (HP:0009465)2.20482913
53Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.19808077
54Renovascular hypertension (HP:0100817)2.19603992
55Hypoglycemic seizures (HP:0002173)2.14529688
56Tarsal synostosis (HP:0008368)2.12019542
57Abnormality of the septum pellucidum (HP:0007375)2.10604855
58Increased nuchal translucency (HP:0010880)2.10254260
59Hyperacusis (HP:0010780)2.09905711
60Short thumb (HP:0009778)2.00802357
61Patellar dislocation (HP:0002999)1.93759518
62Renal duplication (HP:0000075)1.93001247
63Synostosis involving bones of the lower limbs (HP:0009138)1.91042784
64Synostosis involving bones of the feet (HP:0009140)1.91042784
65Abnormal delivery (HP:0001787)1.90876202
66Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.87549672
67Absent hair (HP:0002298)1.86573821
68Short metatarsal (HP:0010743)1.86170544
69Methylmalonic aciduria (HP:0012120)1.85283427
70Pulmonary artery stenosis (HP:0004415)1.83249976
71Abnormality of the middle phalanges of the hand (HP:0009833)1.81540516
72Abnormal biliary tract physiology (HP:0012439)1.81400602
73Bile duct proliferation (HP:0001408)1.81400602
74Synostosis involving bones of the hand (HP:0004278)1.80873899
75Anophthalmia (HP:0000528)1.79626806
76Short tibia (HP:0005736)1.79220618
77Retinal atrophy (HP:0001105)1.79151836
78Urethral obstruction (HP:0000796)1.78712130
79Hyperinsulinemic hypoglycemia (HP:0000825)1.75079157
80Anosmia (HP:0000458)1.73866941
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.72996021
82Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.72072483
83Oral leukoplakia (HP:0002745)1.71042399
84Abnormality of the vitamin B12 metabolism (HP:0004341)1.70402009
85Abnormality of endocrine pancreas physiology (HP:0012093)1.68716290
86Abnormality of the pancreatic islet cells (HP:0006476)1.68716290
87Hypotelorism (HP:0000601)1.68210248
88Hypoglycemic coma (HP:0001325)1.64475704
89Abnormal number of incisors (HP:0011064)1.60103304
90Absent toe (HP:0010760)1.60100330
91Patellar aplasia (HP:0006443)1.60055754
92Sparse eyelashes (HP:0000653)1.59424575
93True hermaphroditism (HP:0010459)1.56216818
94Insomnia (HP:0100785)1.55783363
95Abnormality of midbrain morphology (HP:0002418)1.55366677
96Molar tooth sign on MRI (HP:0002419)1.55366677
97Abnormality of vitamin B metabolism (HP:0004340)1.55350491
98Abnormality of chromosome segregation (HP:0002916)1.54434066
99Limited hip movement (HP:0008800)1.48504497
100Hypoplastic toenails (HP:0001800)1.47950211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD37.54299125
2LATS24.49505515
3TYRO33.76240571
4NUAK13.71840042
5MAP3K42.70565057
6TNIK2.55552732
7VRK22.54314860
8MAPK132.49352082
9DMPK2.44724901
10CSNK1G12.37924265
11MAP2K72.30106780
12CSNK1G32.24259637
13VRK11.97565171
14CSNK1A1L1.95307975
15FRK1.84575485
16DYRK21.83488546
17CSNK1G21.78282263
18RPS6KA41.77574093
19TAF11.61336571
20AKT31.55812633
21MKNK21.54135887
22TRIM281.51680457
23MAP3K121.49119659
24PRKD21.46725485
25ERBB31.39524590
26ATR1.36789758
27TYK21.31793583
28EIF2AK31.30820183
29WEE11.24783434
30MAPKAPK51.24361201
31SRPK11.21045648
32MAP2K41.20135466
33ADRBK21.13710809
34PAK31.08485585
35RAF11.05650035
36MKNK11.00164972
37WNK30.99064639
38STK160.93135317
39PLK30.87751667
40PLK20.83798642
41ILK0.80243451
42FGR0.79594769
43STK390.79205085
44PRKD10.77928880
45WNK40.75982993
46PRKCH0.75264169
47INSRR0.70177779
48BMPR1B0.69875955
49CSNK1A10.62468513
50PLK10.62431882
51STK38L0.61399803
52PRKCE0.60871677
53RPS6KA50.60482930
54EIF2AK20.58517813
55CSNK1E0.57323208
56PDGFRB0.56911657
57CAMK1D0.56605515
58MAPKAPK20.55066558
59NTRK20.50589186
60PASK0.49166917
61TIE10.48056972
62CDK10.47980226
63CAMK1G0.42627816
64ZAK0.42463302
65ATM0.41428768
66CSNK2A10.41103539
67GSK3B0.40932801
68TGFBR10.40373900
69MAPK140.39072271
70ROCK10.39041152
71FGFR20.38913842
72NLK0.37748974
73AURKB0.37682924
74EIF2AK10.37565757
75JAK30.37481933
76TXK0.36035868
77NME10.35929718
78BUB10.34271798
79ABL10.34146601
80PLK40.34138181
81PRKDC0.32074989
82PRKAA20.32038246
83GRK50.30848196
84ITK0.30198504
85MAPK10.29867875
86TNK20.29807036
87SMG10.28788642
88PRKCQ0.28282762
89PTK2B0.27519955
90SGK20.27143457
91TAOK30.26904193
92OXSR10.26020589
93PAK10.24946084
94INSR0.22737889
95TEC0.22559756
96STK30.22530436
97PRKG10.22434964
98PRKCD0.21922757
99PRKACB0.21850267
100CDK70.21612563

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.26938656
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.23555705
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.05281219
4Basal transcription factors_Homo sapiens_hsa030223.18306147
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14449265
6Regulation of autophagy_Homo sapiens_hsa041402.99023861
7Circadian rhythm_Homo sapiens_hsa047102.64886196
8Taste transduction_Homo sapiens_hsa047422.58691135
9Cysteine and methionine metabolism_Homo sapiens_hsa002702.47836907
10Spliceosome_Homo sapiens_hsa030402.44018745
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.35415841
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22294224
13One carbon pool by folate_Homo sapiens_hsa006702.21752436
14RNA transport_Homo sapiens_hsa030132.15240107
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96258608
16Protein export_Homo sapiens_hsa030601.93557357
17Basal cell carcinoma_Homo sapiens_hsa052171.89983308
18RNA polymerase_Homo sapiens_hsa030201.81696622
19Mismatch repair_Homo sapiens_hsa034301.80415667
20Homologous recombination_Homo sapiens_hsa034401.77244739
21Autoimmune thyroid disease_Homo sapiens_hsa053201.74112148
22Propanoate metabolism_Homo sapiens_hsa006401.62907120
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61180117
24Herpes simplex infection_Homo sapiens_hsa051681.58958799
25Fatty acid elongation_Homo sapiens_hsa000621.46097674
26Phototransduction_Homo sapiens_hsa047441.37591842
27DNA replication_Homo sapiens_hsa030301.34654493
28Biosynthesis of amino acids_Homo sapiens_hsa012301.34143991
29Hedgehog signaling pathway_Homo sapiens_hsa043401.30902044
30Nucleotide excision repair_Homo sapiens_hsa034201.26991832
31RNA degradation_Homo sapiens_hsa030181.23705715
32N-Glycan biosynthesis_Homo sapiens_hsa005101.22306631
33Fanconi anemia pathway_Homo sapiens_hsa034601.19543233
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18875936
35Measles_Homo sapiens_hsa051621.07034920
36Caffeine metabolism_Homo sapiens_hsa002321.04315700
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03693119
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98071584
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92586736
40Fatty acid biosynthesis_Homo sapiens_hsa000610.91394063
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91365463
42Non-homologous end-joining_Homo sapiens_hsa034500.91098909
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89157735
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88863158
45Selenocompound metabolism_Homo sapiens_hsa004500.84629977
46TGF-beta signaling pathway_Homo sapiens_hsa043500.84368406
47Proteasome_Homo sapiens_hsa030500.83330778
48Wnt signaling pathway_Homo sapiens_hsa043100.82841718
49Cell cycle_Homo sapiens_hsa041100.81289186
50Retinol metabolism_Homo sapiens_hsa008300.60665537
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57825713
52Type II diabetes mellitus_Homo sapiens_hsa049300.57442163
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56099308
54mRNA surveillance pathway_Homo sapiens_hsa030150.55872167
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52243782
56Nitrogen metabolism_Homo sapiens_hsa009100.49294162
57Pyrimidine metabolism_Homo sapiens_hsa002400.49105413
58Hippo signaling pathway_Homo sapiens_hsa043900.46763890
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45424243
60Shigellosis_Homo sapiens_hsa051310.45109377
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.44003066
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43510179
63ABC transporters_Homo sapiens_hsa020100.41306475
64Glucagon signaling pathway_Homo sapiens_hsa049220.39616969
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38389510
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38129404
67Purine metabolism_Homo sapiens_hsa002300.36751938
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.36741562
69Fructose and mannose metabolism_Homo sapiens_hsa000510.35895423
70Galactose metabolism_Homo sapiens_hsa000520.35726131
71Starch and sucrose metabolism_Homo sapiens_hsa005000.32887588
72Primary immunodeficiency_Homo sapiens_hsa053400.32721940
73Fatty acid metabolism_Homo sapiens_hsa012120.32706886
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31944565
75Hepatitis C_Homo sapiens_hsa051600.31246377
76Peroxisome_Homo sapiens_hsa041460.27560900
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26837618
78p53 signaling pathway_Homo sapiens_hsa041150.26769218
79Systemic lupus erythematosus_Homo sapiens_hsa053220.26278566
80Carbon metabolism_Homo sapiens_hsa012000.25861902
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25416983
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.25185305
83Pentose phosphate pathway_Homo sapiens_hsa000300.25144747
84Chemical carcinogenesis_Homo sapiens_hsa052040.25131919
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23698446
86Alcoholism_Homo sapiens_hsa050340.23242399
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22577070
88Glycerolipid metabolism_Homo sapiens_hsa005610.22440360
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21299120
90Lysine degradation_Homo sapiens_hsa003100.20927916
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20917987
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19606218
93Tryptophan metabolism_Homo sapiens_hsa003800.18517759
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.18399022
95Metabolic pathways_Homo sapiens_hsa011000.18266772
96MAPK signaling pathway_Homo sapiens_hsa040100.18128343
97Huntingtons disease_Homo sapiens_hsa050160.16630883
98Base excision repair_Homo sapiens_hsa034100.16292029
99Cocaine addiction_Homo sapiens_hsa050300.16129536
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13688245

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