RPS2P44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.84960671
2ncRNA 3-end processing (GO:0043628)6.12142893
3polyol catabolic process (GO:0046174)5.69212833
4keratinization (GO:0031424)4.83167040
5positive regulation of protein homooligomerization (GO:0032464)4.81974675
6mitochondrion distribution (GO:0048311)4.75501038
7regulation of nuclear cell cycle DNA replication (GO:0033262)4.45346496
8glycerol metabolic process (GO:0006071)4.33664511
9response to pheromone (GO:0019236)3.96646978
10cytoplasmic mRNA processing body assembly (GO:0033962)3.91605336
11centriole replication (GO:0007099)3.91173675
12phosphatidylglycerol biosynthetic process (GO:0006655)3.88367042
13negative regulation of activin receptor signaling pathway (GO:0032926)3.88172183
14neural tube formation (GO:0001841)3.86534673
15phosphorylated carbohydrate dephosphorylation (GO:0046838)3.83013688
16inositol phosphate dephosphorylation (GO:0046855)3.83013688
17regulation of cell maturation (GO:1903429)3.78513050
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.76841744
19alditol metabolic process (GO:0019400)3.73669431
20reflex (GO:0060004)3.73280992
21protein import into peroxisome matrix (GO:0016558)3.72950527
22response to redox state (GO:0051775)3.69370717
23inositol phosphate catabolic process (GO:0071545)3.68293489
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66432497
25regulation of mitochondrial fission (GO:0090140)3.61353911
26activated T cell proliferation (GO:0050798)3.61054416
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59431403
28GMP metabolic process (GO:0046037)3.59108186
29keratinocyte development (GO:0003334)3.57175105
30negative regulation of transcription regulatory region DNA binding (GO:2000678)3.45032055
31DNA methylation involved in gamete generation (GO:0043046)3.43559221
32ribosomal small subunit assembly (GO:0000028)3.38944270
33positive regulation of meiosis (GO:0045836)3.34259626
34regulation of protein homooligomerization (GO:0032462)3.26362043
35kidney morphogenesis (GO:0060993)3.24160039
36protein polyglutamylation (GO:0018095)3.21602395
37positive regulation of meiotic cell cycle (GO:0051446)3.21303653
38histone H3-K4 trimethylation (GO:0080182)3.21154197
39peptidyl-lysine trimethylation (GO:0018023)3.20898436
40DNA synthesis involved in DNA repair (GO:0000731)3.19534376
41nucleoside diphosphate catabolic process (GO:0009134)3.15529816
42phosphatidylinositol acyl-chain remodeling (GO:0036149)3.10646166
43protein K6-linked ubiquitination (GO:0085020)3.07784619
44regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.05692478
45segment specification (GO:0007379)2.98183681
46monoubiquitinated protein deubiquitination (GO:0035520)2.96001560
47adaptation of signaling pathway (GO:0023058)2.95809885
48piRNA metabolic process (GO:0034587)2.94211176
49phosphatidylglycerol metabolic process (GO:0046471)2.93619345
50positive regulation of mitochondrial fission (GO:0090141)2.93257595
51regulation of sister chromatid cohesion (GO:0007063)2.90787794
52outer ear morphogenesis (GO:0042473)2.89996503
53negative regulation of mast cell activation (GO:0033004)2.87831975
54positive regulation of mRNA processing (GO:0050685)2.86074790
55hepatocyte apoptotic process (GO:0097284)2.83332613
56regulation of energy homeostasis (GO:2000505)2.81733391
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80886611
58phosphatidylserine acyl-chain remodeling (GO:0036150)2.80828612
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78067046
60cilium morphogenesis (GO:0060271)2.76717567
61viral transcription (GO:0019083)2.74730774
62photoreceptor cell maintenance (GO:0045494)2.72286523
63protein localization to synapse (GO:0035418)2.69274369
64negative regulation of systemic arterial blood pressure (GO:0003085)2.69240239
65translational termination (GO:0006415)2.69078733
66negative regulation of cell aging (GO:0090344)2.66656403
67arginine catabolic process (GO:0006527)2.65875228
68rRNA catabolic process (GO:0016075)2.63466979
69positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63287383
70mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63287383
71protein K63-linked deubiquitination (GO:0070536)2.61204425
72establishment of protein localization to Golgi (GO:0072600)2.60268200
73negative regulation of Ras GTPase activity (GO:0034261)2.56431268
74cardiolipin metabolic process (GO:0032048)2.56101596
75preassembly of GPI anchor in ER membrane (GO:0016254)2.55911109
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55218637
77phosphatidylcholine biosynthetic process (GO:0006656)2.54851733
78regulation of alkaline phosphatase activity (GO:0010692)2.53954551
79regulation of gene expression by genetic imprinting (GO:0006349)2.53481191
80detection of mechanical stimulus involved in sensory perception (GO:0050974)2.52998408
81regulation of cilium movement (GO:0003352)2.51608686
82positive regulation of mRNA metabolic process (GO:1903313)2.48710974
83RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.48427246
84fucose catabolic process (GO:0019317)2.48000457
85L-fucose metabolic process (GO:0042354)2.48000457
86L-fucose catabolic process (GO:0042355)2.48000457
87protein K11-linked deubiquitination (GO:0035871)2.47399891
88positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.46895743
89regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.46895743
90negative regulation of DNA binding (GO:0043392)2.46533154
91kinetochore assembly (GO:0051382)2.46143135
92phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.45486488
93DNA deamination (GO:0045006)2.45385189
94synaptic vesicle maturation (GO:0016188)2.42855377
95dentate gyrus development (GO:0021542)2.39214432
96protein targeting to peroxisome (GO:0006625)2.39026083
97establishment of protein localization to peroxisome (GO:0072663)2.39026083
98protein localization to peroxisome (GO:0072662)2.39026083
99phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.37458671
100anterograde synaptic vesicle transport (GO:0048490)2.36850607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela5.19417685
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04147187
3IRF1_19129219_ChIP-ChIP_H3396_Human2.88149039
4VDR_22108803_ChIP-Seq_LS180_Human2.75251405
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54306264
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50297287
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31115754
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29748521
9BCAT_22108803_ChIP-Seq_LS180_Human2.26360085
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22124426
11FUS_26573619_Chip-Seq_HEK293_Human2.20781747
12EWS_26573619_Chip-Seq_HEK293_Human2.06080846
13TP53_16413492_ChIP-PET_HCT116_Human2.05523600
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02568914
15P300_19829295_ChIP-Seq_ESCs_Human2.00630629
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91572868
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91572868
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85696284
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82884748
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.76299172
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61967221
22GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.61016445
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.60380662
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58957071
25TAF15_26573619_Chip-Seq_HEK293_Human1.55136625
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53632607
27ER_23166858_ChIP-Seq_MCF-7_Human1.53550645
28TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.50991234
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49674967
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48918880
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48881631
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45599901
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.44800686
34AR_21572438_ChIP-Seq_LNCaP_Human1.43553674
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43453532
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41678991
37STAT3_23295773_ChIP-Seq_U87_Human1.40374789
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.39450343
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38660680
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38363886
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.38143876
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37553215
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33700600
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.33311964
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.33119664
46TCF4_23295773_ChIP-Seq_U87_Human1.32904668
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31639745
48AR_25329375_ChIP-Seq_VCAP_Human1.31307936
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29580895
50CBP_20019798_ChIP-Seq_JUKART_Human1.29580895
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29345831
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28873856
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.28100394
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27176622
55NCOR_22424771_ChIP-Seq_293T_Human1.26845682
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.25956094
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23330791
58SMAD4_21799915_ChIP-Seq_A2780_Human1.23145446
59RNF2_27304074_Chip-Seq_NSC_Mouse1.22682889
60GBX2_23144817_ChIP-Seq_PC3_Human1.22049434
61TCF4_22108803_ChIP-Seq_LS180_Human1.21889579
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21130650
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19419631
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19267117
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17642015
66TP53_22573176_ChIP-Seq_HFKS_Human1.17102961
67REST_21632747_ChIP-Seq_MESCs_Mouse1.16819944
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16236456
69RUNX2_22187159_ChIP-Seq_PCA_Human1.15851726
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.15354299
71NANOG_19829295_ChIP-Seq_ESCs_Human1.14720639
72SOX2_19829295_ChIP-Seq_ESCs_Human1.14720639
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.14285273
74MYC_18940864_ChIP-ChIP_HL60_Human1.12575704
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12039035
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10152541
77CDX2_22108803_ChIP-Seq_LS180_Human1.09937079
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09210901
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.09210901
80IGF1R_20145208_ChIP-Seq_DFB_Human1.08840016
81EGR1_19032775_ChIP-ChIP_M12_Human1.08544947
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07215366
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06410155
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.06375838
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06325319
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.05345160
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04836173
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04789660
89SMRT_27268052_Chip-Seq_Bcells_Human1.04415214
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.04098867
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.03365019
92RUNX_20019798_ChIP-Seq_JUKART_Human1.03024147
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02460607
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02182466
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01819777
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.01592821
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.00825779
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.98516317
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.97812516
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96433501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.98238320
2MP0008877_abnormal_DNA_methylation3.88817139
3MP0004510_myositis3.88361187
4MP0006054_spinal_hemorrhage3.04168804
5MP0002163_abnormal_gland_morphology3.00842009
6MP0009780_abnormal_chondrocyte_physiolo2.91444514
7MP0003787_abnormal_imprinting2.69153627
8MP0003121_genomic_imprinting2.67169950
9MP0005174_abnormal_tail_pigmentation2.58363046
10MP0006082_CNS_inflammation2.52897593
11MP0003195_calcinosis2.48096461
12MP0001873_stomach_inflammation2.45317816
13MP0004885_abnormal_endolymph2.44849263
14MP0008995_early_reproductive_senescence2.44679016
15MP0003646_muscle_fatigue2.33696541
16MP0000015_abnormal_ear_pigmentation2.19315530
17MP0003183_abnormal_peptide_metabolism1.86033726
18MP0003567_abnormal_fetal_cardiomyocyte1.85482060
19MP0008057_abnormal_DNA_replication1.78938391
20MP0005551_abnormal_eye_electrophysiolog1.77768042
21MP0002876_abnormal_thyroid_physiology1.76132415
22MP0005379_endocrine/exocrine_gland_phen1.70089187
23MP0009764_decreased_sensitivity_to1.70004888
24MP0006292_abnormal_olfactory_placode1.69949369
25MP0000566_synostosis1.69506900
26MP0000427_abnormal_hair_cycle1.67775688
27MP0004133_heterotaxia1.66273302
28MP0003724_increased_susceptibility_to1.65656869
29MP0001485_abnormal_pinna_reflex1.64454805
30MP0002653_abnormal_ependyma_morphology1.64029877
31MP0001727_abnormal_embryo_implantation1.61738277
32MP0009765_abnormal_xenobiotic_induced1.60566121
33MP0008875_abnormal_xenobiotic_pharmacok1.60412421
34MP0003879_abnormal_hair_cell1.56822981
35MP0004142_abnormal_muscle_tone1.50692529
36MP0005377_hearing/vestibular/ear_phenot1.39097739
37MP0003878_abnormal_ear_physiology1.39097739
38MP0002095_abnormal_skin_pigmentation1.38356005
39MP0001501_abnormal_sleep_pattern1.34205543
40MP0009745_abnormal_behavioral_response1.33459692
41MP0003786_premature_aging1.27895995
42MP0001800_abnormal_humoral_immune1.24477598
43MP0003938_abnormal_ear_development1.19982463
44MP0005367_renal/urinary_system_phenotyp1.17655615
45MP0000516_abnormal_urinary_system1.17655615
46MP0003950_abnormal_plasma_membrane1.15271794
47MP0004742_abnormal_vestibular_system1.14386375
48MP0003755_abnormal_palate_morphology1.12840699
49MP0009046_muscle_twitch1.11730944
50MP0003172_abnormal_lysosome_physiology1.11082421
51MP0002796_impaired_skin_barrier1.10874780
52MP0004484_altered_response_of1.08369757
53MP0002837_dystrophic_cardiac_calcinosis1.06377625
54MP0005187_abnormal_penis_morphology1.04218987
55MP0000647_abnormal_sebaceous_gland1.03963244
56MP0001968_abnormal_touch/_nociception1.02538697
57MP0002277_abnormal_respiratory_mucosa1.02208528
58MP0000631_abnormal_neuroendocrine_gland1.00200919
59MP0004381_abnormal_hair_follicle0.98541006
60MP0002933_joint_inflammation0.95142360
61MP0001984_abnormal_olfaction0.91702099
62MP0002102_abnormal_ear_morphology0.91422494
63MP0001986_abnormal_taste_sensitivity0.90733649
64MP0003136_yellow_coat_color0.89111579
65MP0004264_abnormal_extraembryonic_tissu0.87029076
66MP0002210_abnormal_sex_determination0.86169897
67MP0002160_abnormal_reproductive_system0.85676517
68MP0002272_abnormal_nervous_system0.83910895
69MP0001502_abnormal_circadian_rhythm0.83072422
70MP0000026_abnormal_inner_ear0.81870923
71MP0001119_abnormal_female_reproductive0.79424030
72MP0003283_abnormal_digestive_organ0.79303883
73MP0006276_abnormal_autonomic_nervous0.78838887
74MP0009333_abnormal_splenocyte_physiolog0.78598687
75MP0001905_abnormal_dopamine_level0.77187725
76MP0005389_reproductive_system_phenotype0.74801545
77MP0000613_abnormal_salivary_gland0.74017043
78MP0008961_abnormal_basal_metabolism0.73242118
79MP0004924_abnormal_behavior0.73040168
80MP0005386_behavior/neurological_phenoty0.73040168
81MP0005671_abnormal_response_to0.73016933
82MP0002928_abnormal_bile_duct0.71923638
83MP0005397_hematopoietic_system_phenotyp0.70621016
84MP0001545_abnormal_hematopoietic_system0.70621016
85MP0004947_skin_inflammation0.70303525
86MP0001929_abnormal_gametogenesis0.69443218
87MP0001486_abnormal_startle_reflex0.68420967
88MP0000653_abnormal_sex_gland0.68106932
89MP0008058_abnormal_DNA_repair0.67283098
90MP0001970_abnormal_pain_threshold0.67023717
91MP0003936_abnormal_reproductive_system0.66510215
92MP0000049_abnormal_middle_ear0.66371009
93MP0005085_abnormal_gallbladder_physiolo0.66343365
94MP0002572_abnormal_emotion/affect_behav0.64240079
95MP0005075_abnormal_melanosome_morpholog0.63308082
96MP0002229_neurodegeneration0.62552977
97MP0000749_muscle_degeneration0.61886838
98MP0005195_abnormal_posterior_eye0.61061983
99MP0002138_abnormal_hepatobiliary_system0.60213443
100MP0003656_abnormal_erythrocyte_physiolo0.59953941

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.91305211
2Abnormality of macular pigmentation (HP:0008002)5.34355322
3Constricted visual fields (HP:0001133)4.77961356
4Attenuation of retinal blood vessels (HP:0007843)4.12267196
5Pancreatic fibrosis (HP:0100732)3.96615721
6Metaphyseal cupping (HP:0003021)3.90416231
7Cone-rod dystrophy (HP:0000548)3.83485861
8Decreased electroretinogram (ERG) amplitude (HP:0000654)3.81142561
9Striae distensae (HP:0001065)3.64087349
10Volvulus (HP:0002580)3.59140867
11Pancreatic cysts (HP:0001737)3.53753418
12True hermaphroditism (HP:0010459)3.36013519
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22454967
14Rib fusion (HP:0000902)3.14099660
15Asplenia (HP:0001746)3.11486062
16Aplasia/Hypoplasia of the spleen (HP:0010451)3.05946292
17Cupped ribs (HP:0000887)3.02588711
18Hypoplastic ischia (HP:0003175)2.87846997
19Oligodontia (HP:0000677)2.83945525
20Furrowed tongue (HP:0000221)2.79621514
21Calf muscle hypertrophy (HP:0008981)2.74832656
22Round ear (HP:0100830)2.70823738
23Abnormal rod and cone electroretinograms (HP:0008323)2.68775843
24Hyperglycinemia (HP:0002154)2.64260907
25Molar tooth sign on MRI (HP:0002419)2.64217071
26Abnormality of midbrain morphology (HP:0002418)2.64217071
27Small hand (HP:0200055)2.62882590
28Gaze-evoked nystagmus (HP:0000640)2.58632902
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55303623
30Genetic anticipation (HP:0003743)2.52955067
31Methylmalonic aciduria (HP:0012120)2.50459866
32Septo-optic dysplasia (HP:0100842)2.48457264
33Medial flaring of the eyebrow (HP:0010747)2.47071791
34Abnormality of lateral ventricle (HP:0030047)2.40968027
35Ectropion (HP:0000656)2.38935379
36Cystic liver disease (HP:0006706)2.38909554
37Abnormality of the ischium (HP:0003174)2.36948102
38Decreased muscle mass (HP:0003199)2.35896438
39Neoplasm of the adrenal cortex (HP:0100641)2.34380241
40Lack of skin elasticity (HP:0100679)2.33686000
41Muscle hypertrophy of the lower extremities (HP:0008968)2.32610647
42Postnatal growth retardation (HP:0008897)2.31729355
43Aplasia/Hypoplasia of the earlobes (HP:0009906)2.28994829
44Increased density of long bones (HP:0006392)2.28289611
45Hypoplastic ilia (HP:0000946)2.27418659
46Unsteady gait (HP:0002317)2.25962837
47Toxemia of pregnancy (HP:0100603)2.25161917
48Supernumerary spleens (HP:0009799)2.22071665
49Severe visual impairment (HP:0001141)2.20893257
50Congenital stationary night blindness (HP:0007642)2.20831669
51Retinitis pigmentosa (HP:0000510)2.16728435
52Anencephaly (HP:0002323)2.16086469
53Abnormality of the lower motor neuron (HP:0002366)2.15194809
54Diastasis recti (HP:0001540)2.14408726
55Amyotrophic lateral sclerosis (HP:0007354)2.13796523
56Progressive cerebellar ataxia (HP:0002073)2.13476729
57Sclerocornea (HP:0000647)2.11840587
58Large earlobe (HP:0009748)2.11509262
59Optic nerve hypoplasia (HP:0000609)2.11456442
60Gait imbalance (HP:0002141)2.10529346
61Broad-based gait (HP:0002136)2.09502279
62Nephronophthisis (HP:0000090)2.09479276
63Hyperthyroidism (HP:0000836)2.09053553
64Adrenal hypoplasia (HP:0000835)2.08082294
65Congenital primary aphakia (HP:0007707)2.04052849
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.01940501
67Abnormality of the renal cortex (HP:0011035)1.96471816
68Concave nail (HP:0001598)1.96026907
69Poor coordination (HP:0002370)1.95751717
70Occipital encephalocele (HP:0002085)1.94651105
71Abnormality of nail color (HP:0100643)1.93849773
72Bile duct proliferation (HP:0001408)1.92798253
73Abnormal biliary tract physiology (HP:0012439)1.92798253
74Optic disc pallor (HP:0000543)1.89611702
75Widely spaced teeth (HP:0000687)1.88928433
76Male pseudohermaphroditism (HP:0000037)1.86813551
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84668936
78Protruding tongue (HP:0010808)1.84499880
79Abnormality of the renal medulla (HP:0100957)1.83643761
80Nephrogenic diabetes insipidus (HP:0009806)1.83591868
81Absent septum pellucidum (HP:0001331)1.82525062
82Tibial bowing (HP:0002982)1.81716338
83Hypoplastic iliac wings (HP:0002866)1.80331288
84Broad nasal tip (HP:0000455)1.79782208
85Multicystic kidney dysplasia (HP:0000003)1.76735424
86Chronic hepatic failure (HP:0100626)1.76226184
87Preauricular skin tag (HP:0000384)1.75092561
88Oligodactyly (hands) (HP:0001180)1.74701891
89Gingival bleeding (HP:0000225)1.73466571
90Decreased central vision (HP:0007663)1.72958663
91Prominent supraorbital ridges (HP:0000336)1.72217749
92Congenital hepatic fibrosis (HP:0002612)1.69366883
93Cystic hygroma (HP:0000476)1.69352827
94Astigmatism (HP:0000483)1.66703317
95Abnormality of the labia minora (HP:0012880)1.65985138
96Abnormality of DNA repair (HP:0003254)1.65847506
97Abnormality of the septum pellucidum (HP:0007375)1.65581177
98Postaxial foot polydactyly (HP:0001830)1.65010939
99Fair hair (HP:0002286)1.64227725
100Intellectual disability, severe (HP:0010864)1.63310947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.89749474
2FRK4.74801990
3KIT3.84330266
4TXK2.98485120
5TNIK2.77630309
6TEC2.45415584
7ADRBK22.33278111
8MAP4K12.32286853
9TAOK32.27572503
10BRSK22.04859578
11FES1.95290282
12STK38L1.94967915
13PINK11.86474683
14EIF2AK11.82928847
15ZAK1.72956601
16GRK11.58741031
17CDK191.55815996
18IKBKB1.52174934
19PAK31.42594390
20SIK21.39467528
21MST41.26508607
22TAF11.25743433
23TYRO31.24102450
24SYK1.16812648
25MUSK1.15868525
26WNK31.08490043
27IKBKE1.04594752
28PLK21.03690738
29DYRK31.02464125
30STK241.00902079
31FGFR21.00319148
32TLK10.97928107
33SGK20.97569605
34STK110.97200430
35CAMKK20.94136028
36WNK40.90680044
37ADRBK10.90443866
38MARK30.87841779
39LRRK20.87776002
40NUAK10.87470085
41PIK3CG0.84899244
42STK30.84639361
43PRKCQ0.82479793
44PIK3CA0.82290783
45MAP3K40.80522210
46OXSR10.80472010
47CSK0.80179154
48SGK2230.76702022
49SGK4940.76702022
50PLK30.76300714
51BMPR1B0.72535321
52PRKCI0.71525769
53WNK10.69847534
54BTK0.69430973
55MAPK130.66573765
56BRSK10.63915932
57PRKCE0.63711935
58FGR0.63264270
59CDK80.62195087
60CAMK1D0.60480198
61DYRK20.58437323
62CAMK40.58011027
63GRK50.57578321
64EIF2AK30.56926433
65BCKDK0.56870428
66BCR0.55687329
67NEK90.54582005
68CDK30.53690096
69PRKCG0.51225902
70PRKAA20.51147939
71PKN10.50897737
72PTK2B0.49668875
73CAMK1G0.49402039
74TTK0.47435364
75BRD40.47167877
76OBSCN0.46593236
77CHEK20.45427051
78CCNB10.45127355
79INSRR0.44116736
80CSNK1D0.43782130
81MKNK20.42973777
82GRK70.42048212
83ACVR1B0.41058764
84CAMK10.41000943
85NEK10.40575260
86DYRK1A0.40209884
87SGK10.37483933
88ITK0.37258746
89PRKACA0.37090390
90PRKCZ0.36479323
91EIF2AK20.35779105
92STK100.35587936
93PRKCH0.34708075
94ATM0.33646625
95EPHA40.33586138
96MAP2K60.33391149
97EGFR0.33020972
98NLK0.32686104
99INSR0.32448038
100LCK0.32207529

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.50203221
2Linoleic acid metabolism_Homo sapiens_hsa005913.31751129
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.19289629
4Ribosome_Homo sapiens_hsa030102.82499782
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.78024937
6Oxidative phosphorylation_Homo sapiens_hsa001902.51917416
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.37644668
8Arachidonic acid metabolism_Homo sapiens_hsa005902.26139892
9Ether lipid metabolism_Homo sapiens_hsa005652.23310018
10Parkinsons disease_Homo sapiens_hsa050122.10659595
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07239995
12Caffeine metabolism_Homo sapiens_hsa002322.04562669
13RNA degradation_Homo sapiens_hsa030181.95773525
14Propanoate metabolism_Homo sapiens_hsa006401.78752134
15Fat digestion and absorption_Homo sapiens_hsa049751.71529270
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71212319
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69248905
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57562105
19Huntingtons disease_Homo sapiens_hsa050161.54430529
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53670110
21Olfactory transduction_Homo sapiens_hsa047401.50825777
22Nitrogen metabolism_Homo sapiens_hsa009101.46172667
23Homologous recombination_Homo sapiens_hsa034401.41404876
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39938116
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.35471922
26Alzheimers disease_Homo sapiens_hsa050101.34471483
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33781026
28Taste transduction_Homo sapiens_hsa047421.33375889
29Fanconi anemia pathway_Homo sapiens_hsa034601.27580785
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27538938
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.26592886
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25186911
33Butanoate metabolism_Homo sapiens_hsa006501.12442906
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.11936990
35Circadian rhythm_Homo sapiens_hsa047101.06324374
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04672579
37Basal transcription factors_Homo sapiens_hsa030221.04482563
38FoxO signaling pathway_Homo sapiens_hsa040680.98675803
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97712295
40Nicotine addiction_Homo sapiens_hsa050330.97036974
41Basal cell carcinoma_Homo sapiens_hsa052170.93887242
42p53 signaling pathway_Homo sapiens_hsa041150.93767328
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90905537
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85987280
45Peroxisome_Homo sapiens_hsa041460.82218707
46RNA polymerase_Homo sapiens_hsa030200.81776437
47Dorso-ventral axis formation_Homo sapiens_hsa043200.81772262
48Retinol metabolism_Homo sapiens_hsa008300.81744230
49Ovarian steroidogenesis_Homo sapiens_hsa049130.81448197
50Chemical carcinogenesis_Homo sapiens_hsa052040.80312175
51Hedgehog signaling pathway_Homo sapiens_hsa043400.76807571
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73620345
53Glycerolipid metabolism_Homo sapiens_hsa005610.72489386
54Tryptophan metabolism_Homo sapiens_hsa003800.72289659
55One carbon pool by folate_Homo sapiens_hsa006700.71830501
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.70427792
57Cardiac muscle contraction_Homo sapiens_hsa042600.70143428
58Notch signaling pathway_Homo sapiens_hsa043300.69575725
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67917450
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.66476131
61Staphylococcus aureus infection_Homo sapiens_hsa051500.66346813
62Proteasome_Homo sapiens_hsa030500.65752688
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63543774
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60093314
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59500174
66T cell receptor signaling pathway_Homo sapiens_hsa046600.58541349
67Glutamatergic synapse_Homo sapiens_hsa047240.57563526
68Long-term depression_Homo sapiens_hsa047300.56779157
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54578839
70Choline metabolism in cancer_Homo sapiens_hsa052310.54388862
71Mismatch repair_Homo sapiens_hsa034300.54134749
72cAMP signaling pathway_Homo sapiens_hsa040240.52523030
73Tuberculosis_Homo sapiens_hsa051520.52443586
74Lysine degradation_Homo sapiens_hsa003100.50614654
75Mineral absorption_Homo sapiens_hsa049780.49443404
76Graft-versus-host disease_Homo sapiens_hsa053320.47260325
77Malaria_Homo sapiens_hsa051440.45981356
78Hematopoietic cell lineage_Homo sapiens_hsa046400.45601887
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44144969
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43558812
81Type I diabetes mellitus_Homo sapiens_hsa049400.42490123
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42133712
83Pyrimidine metabolism_Homo sapiens_hsa002400.40064171
84Measles_Homo sapiens_hsa051620.39748254
85Melanoma_Homo sapiens_hsa052180.39686555
86Calcium signaling pathway_Homo sapiens_hsa040200.38592613
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.38308973
88Metabolic pathways_Homo sapiens_hsa011000.37573286
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37091976
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35893589
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35069843
92Purine metabolism_Homo sapiens_hsa002300.35056275
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33787098
94Ras signaling pathway_Homo sapiens_hsa040140.33473895
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.32659913
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.32134532
97Histidine metabolism_Homo sapiens_hsa003400.32047421
98Sulfur relay system_Homo sapiens_hsa041220.31912188
99Fatty acid degradation_Homo sapiens_hsa000710.31761976
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29685117

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