ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sulfation (GO:0051923)	5.82892093
2	behavioral response to nicotine (GO:0035095)	4.75276814
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.63525155
4	cellular response to ATP (GO:0071318)	4.59462325
5	DNA deamination (GO:0045006)	4.28831798
6	response to pheromone (GO:0019236)	4.10003747
7	indolalkylamine metabolic process (GO:0006586)	4.01344822
8	tryptophan catabolic process (GO:0006569)	3.95132626
9	indole-containing compound catabolic process (GO:0042436)	3.95132626
10	indolalkylamine catabolic process (GO:0046218)	3.95132626
11	negative regulation of systemic arterial blood pressure (GO:0003085)	3.86162859
12	negative regulation of telomere maintenance (GO:0032205)	3.81150591
13	kynurenine metabolic process (GO:0070189)	3.79906508
14	cell proliferation in forebrain (GO:0021846)	3.71131996
15	tryptophan metabolic process (GO:0006568)	3.69837822
16	protein polyglutamylation (GO:0018095)	3.63891032
17	positive regulation of cAMP-mediated signaling (GO:0043950)	3.59222602
18	L-fucose catabolic process (GO:0042355)	3.56906723
19	fucose catabolic process (GO:0019317)	3.56906723
20	L-fucose metabolic process (GO:0042354)	3.56906723
21	DNA methylation involved in gamete generation (GO:0043046)	3.53798121
22	piRNA metabolic process (GO:0034587)	3.51738771
23	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.43756089
24	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.43756089
25	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.43414010
26	sphingosine metabolic process (GO:0006670)	3.38983045
27	detection of light stimulus involved in visual perception (GO:0050908)	3.32337903
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.32337903
29	protein K11-linked deubiquitination (GO:0035871)	3.31580485
30	regulation of glomerulus development (GO:0090192)	3.29355944
31	regulation of meiosis I (GO:0060631)	3.25334796
32	gamma-aminobutyric acid transport (GO:0015812)	3.24335440
33	negative regulation of mast cell activation (GO:0033004)	3.21503094
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.14794003
35	NADH dehydrogenase complex assembly (GO:0010257)	3.14794003
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.14794003
37	sphingoid metabolic process (GO:0046519)	3.13027286
38	flavonoid metabolic process (GO:0009812)	3.10369480
39	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.07932712
40	regulation of hippo signaling (GO:0035330)	3.07616525
41	tachykinin receptor signaling pathway (GO:0007217)	3.06694047
42	diol metabolic process (GO:0034311)	3.05858732
43	dentate gyrus development (GO:0021542)	3.05707881
44	cellular biogenic amine catabolic process (GO:0042402)	3.04628476
45	amine catabolic process (GO:0009310)	3.04628476
46	regulation of neurotransmitter uptake (GO:0051580)	3.01954140
47	indole-containing compound metabolic process (GO:0042430)	2.97211523
48	transmission of nerve impulse (GO:0019226)	2.95590111
49	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.95280853
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89509321
51	peristalsis (GO:0030432)	2.88551944
52	protein complex biogenesis (GO:0070271)	2.88022113
53	regulation of telomere maintenance (GO:0032204)	2.80731749
54	regulation of cell proliferation involved in kidney development (GO:1901722)	2.78852220
55	heme transport (GO:0015886)	2.78157181
56	reflex (GO:0060004)	2.78037138
57	cellular ketone body metabolic process (GO:0046950)	2.77431152
58	phasic smooth muscle contraction (GO:0014821)	2.73791346
59	regulation of cilium movement (GO:0003352)	2.73234483
60	positive regulation of fatty acid oxidation (GO:0046321)	2.72146398
61	dopamine transport (GO:0015872)	2.71320511
62	aromatic amino acid family catabolic process (GO:0009074)	2.69115891
63	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65544543
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65544543
65	male meiosis I (GO:0007141)	2.65038292
66	mannosylation (GO:0097502)	2.64970626
67	cytidine deamination (GO:0009972)	2.60657778
68	cytidine metabolic process (GO:0046087)	2.60657778
69	cytidine catabolic process (GO:0006216)	2.60657778
70	serotonin metabolic process (GO:0042428)	2.59339444
71	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.59262824
72	spinal cord motor neuron differentiation (GO:0021522)	2.58712674
73	positive regulation of meiosis (GO:0045836)	2.58710880
74	primary amino compound metabolic process (GO:1901160)	2.56436508
75	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56143693
76	regulation of phospholipid biosynthetic process (GO:0071071)	2.55423411
77	platelet dense granule organization (GO:0060155)	2.54373293
78	multicellular organismal movement (GO:0050879)	2.54133696
79	musculoskeletal movement (GO:0050881)	2.54133696
80	pharyngeal system development (GO:0060037)	2.53935327
81	neuronal action potential (GO:0019228)	2.53339285
82	adaptation of signaling pathway (GO:0023058)	2.51994080
83	sulfate transmembrane transport (GO:1902358)	2.51986800
84	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51238538
85	regulation of mesoderm development (GO:2000380)	2.51130382
86	rhodopsin mediated signaling pathway (GO:0016056)	2.51019866
87	photoreceptor cell development (GO:0042461)	2.50926405
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.50865073
89	negative regulation of response to food (GO:0032096)	2.50327420
90	negative regulation of appetite (GO:0032099)	2.50327420
91	ketone body metabolic process (GO:1902224)	2.50250289
92	prenylation (GO:0097354)	2.49895504
93	protein prenylation (GO:0018342)	2.49895504
94	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.49343917
95	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.49343917
96	endoderm formation (GO:0001706)	2.49088739
97	DNA double-strand break processing (GO:0000729)	2.47860651
98	regulation of sequestering of triglyceride (GO:0010889)	2.47443551
99	rRNA catabolic process (GO:0016075)	2.47351197
100	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47104894

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23631417
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.19581978
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.72192557
4	VDR_22108803_ChIP-Seq_LS180_Human	2.64547818
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57750789
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56310775
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.48013438
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.45329447
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31416851
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25891860
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25750641
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20157355
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14393080
14	P300_19829295_ChIP-Seq_ESCs_Human	2.10458847
15	FUS_26573619_Chip-Seq_HEK293_Human	2.00372268
16	EWS_26573619_Chip-Seq_HEK293_Human	1.99832760
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91081176
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.84295056
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81495906
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80051718
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78081522
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77826471
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68161181
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.65608837
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65608837
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.59969568
27	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58260031
28	STAT3_23295773_ChIP-Seq_U87_Human	1.58052468
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.57053726
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.56781566
31	AR_21572438_ChIP-Seq_LNCaP_Human	1.52499612
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51274616
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50603228
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48728994
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48444873
36	TCF4_23295773_ChIP-Seq_U87_Human	1.48161504
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48141970
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47378049
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46987871
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45528408
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45244771
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44388851
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42102686
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39519483
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39455686
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39252295
47	AR_25329375_ChIP-Seq_VCAP_Human	1.39099872
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38901080
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38901080
50	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.34201705
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.33395499
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33058754
53	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.32853307
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31342610
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30905744
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29591193
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29034586
58	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.27260021
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.25930681
60	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.25688956
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25353930
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24415115
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24290459
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24290459
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23282918
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21872395
67	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.21801547
68	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20098402
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18520734
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18302927
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18269511
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.17606133
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17276139
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14724587
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14475299
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13463206
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13419647
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.13206584
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13200306
80	NCOR_22424771_ChIP-Seq_293T_Human	1.12664331
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12632844
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10321438
83	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.09781042
84	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09289741
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09289741
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08922904
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08177521
88	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07980187
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06727354
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06372890
91	TP53_16413492_ChIP-PET_HCT116_Human	1.06303350
92	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06115750
93	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.06002101
94	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05656242
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04970047
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02513351
97	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.02205352
98	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01551698
99	AR_20517297_ChIP-Seq_VCAP_Human	0.99297016
100	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98441358

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.10925468
2	MP0003195_calcinosis	3.54656732
3	MP0002138_abnormal_hepatobiliary_system	3.02073080
4	MP0005171_absent_coat_pigmentation	2.97185212
5	MP0002653_abnormal_ependyma_morphology	2.71727501
6	MP0008877_abnormal_DNA_methylation	2.65258200
7	MP0003136_yellow_coat_color	2.62554567
8	MP0005646_abnormal_pituitary_gland	2.55485151
9	MP0003646_muscle_fatigue	2.42875174
10	MP0006292_abnormal_olfactory_placode	2.42064504
11	MP0002102_abnormal_ear_morphology	2.35788878
12	MP0005551_abnormal_eye_electrophysiolog	2.25780964
13	MP0002876_abnormal_thyroid_physiology	2.24026848
14	MP0008872_abnormal_physiological_respon	2.21788347
15	MP0003890_abnormal_embryonic-extraembry	2.15660472
16	MP0006072_abnormal_retinal_apoptosis	2.08991177
17	MP0004885_abnormal_endolymph	1.93316279
18	MP0001485_abnormal_pinna_reflex	1.92973988
19	MP0004147_increased_porphyrin_level	1.87427443
20	MP0000569_abnormal_digit_pigmentation	1.81839586
21	MP0009046_muscle_twitch	1.81433087
22	MP0002163_abnormal_gland_morphology	1.80177896
23	MP0000372_irregular_coat_pigmentation	1.76036200
24	MP0003045_fibrosis	1.74229871
25	MP0002272_abnormal_nervous_system	1.73123148
26	MP0004142_abnormal_muscle_tone	1.71045310
27	MP0004145_abnormal_muscle_electrophysio	1.69358836
28	MP0001968_abnormal_touch/_nociception	1.64120380
29	MP0002254_reproductive_system_inflammat	1.59697734
30	MP0002160_abnormal_reproductive_system	1.57643603
31	MP0009745_abnormal_behavioral_response	1.57354442
32	MP0003787_abnormal_imprinting	1.56827016
33	MP0002938_white_spotting	1.56556207
34	MP0000631_abnormal_neuroendocrine_gland	1.52099839
35	MP0005084_abnormal_gallbladder_morpholo	1.49628027
36	MP0004134_abnormal_chest_morphology	1.48628597
37	MP0005253_abnormal_eye_physiology	1.41449105
38	MP0002928_abnormal_bile_duct	1.35265881
39	MP0005389_reproductive_system_phenotype	1.35159477
40	MP0005379_endocrine/exocrine_gland_phen	1.34799920
41	MP0001986_abnormal_taste_sensitivity	1.33570286
42	MP0004133_heterotaxia	1.28473556
43	MP0001486_abnormal_startle_reflex	1.27481276
44	MP0005174_abnormal_tail_pigmentation	1.25755268
45	MP0002735_abnormal_chemical_nociception	1.24091408
46	MP0001501_abnormal_sleep_pattern	1.21576048
47	MP0004043_abnormal_pH_regulation	1.18623786
48	MP0002736_abnormal_nociception_after	1.17024821
49	MP0008875_abnormal_xenobiotic_pharmacok	1.15552314
50	MP0000427_abnormal_hair_cycle	1.12884470
51	MP0000613_abnormal_salivary_gland	1.11499016
52	MP0005645_abnormal_hypothalamus_physiol	1.08890691
53	MP0001970_abnormal_pain_threshold	1.08837356
54	MP0002733_abnormal_thermal_nociception	1.07941756
55	MP0001984_abnormal_olfaction	1.05408162
56	MP0006276_abnormal_autonomic_nervous	1.02443731
57	MP0003880_abnormal_central_pattern	1.01252168
58	MP0002064_seizures	0.98139201
59	MP0003252_abnormal_bile_duct	0.97995021
60	MP0005195_abnormal_posterior_eye	0.97237357
61	MP0002734_abnormal_mechanical_nocicepti	0.93930868
62	MP0009780_abnormal_chondrocyte_physiolo	0.93276589
63	MP0004130_abnormal_muscle_cell	0.92887433
64	MP0005410_abnormal_fertilization	0.91554668
65	MP0000049_abnormal_middle_ear	0.90007441
66	MP0000230_abnormal_systemic_arterial	0.89805117
67	MP0005085_abnormal_gallbladder_physiolo	0.87561381
68	MP0005075_abnormal_melanosome_morpholog	0.87538370
69	MP0008789_abnormal_olfactory_epithelium	0.87164255
70	MP0002572_abnormal_emotion/affect_behav	0.87031893
71	MP0001764_abnormal_homeostasis	0.85913996
72	MP0002751_abnormal_autonomic_nervous	0.85813386
73	MP0003638_abnormal_response/metabolism_	0.85411111
74	MP0005360_urolithiasis	0.85072107
75	MP0003011_delayed_dark_adaptation	0.82667601
76	MP0003879_abnormal_hair_cell	0.82411108
77	MP0002277_abnormal_respiratory_mucosa	0.81823867
78	MP0002095_abnormal_skin_pigmentation	0.79760305
79	MP0002168_other_aberrant_phenotype	0.79257208
80	MP0002557_abnormal_social/conspecific_i	0.78353934
81	MP0002184_abnormal_innervation	0.78321756
82	MP0002752_abnormal_somatic_nervous	0.78057610
83	MP0003937_abnormal_limbs/digits/tail_de	0.77820021
84	MP0005332_abnormal_amino_acid	0.76929631
85	MP0003137_abnormal_impulse_conducting	0.75245987
86	MP0001963_abnormal_hearing_physiology	0.74948364
87	MP0009250_abnormal_appendicular_skeleto	0.74602866
88	MP0009764_decreased_sensitivity_to	0.72971106
89	MP0001440_abnormal_grooming_behavior	0.71081101
90	MP0003718_maternal_effect	0.70845869
91	MP0005220_abnormal_exocrine_pancreas	0.70514056
92	MP0005448_abnormal_energy_balance	0.69473115
93	MP0000026_abnormal_inner_ear	0.68851352
94	MP0004215_abnormal_myocardial_fiber	0.67838112
95	MP0000653_abnormal_sex_gland	0.67510716
96	MP0010329_abnormal_lipoprotein_level	0.67334189
97	MP0001145_abnormal_male_reproductive	0.66469018
98	MP0005670_abnormal_white_adipose	0.65541156
99	MP0005395_other_phenotype	0.65085473
100	MP0005365_abnormal_bile_salt	0.64821425

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.70889615
2	Pancreatic fibrosis (HP:0100732)	4.18181747
3	True hermaphroditism (HP:0010459)	3.78591635
4	Pendular nystagmus (HP:0012043)	3.72913139
5	Methylmalonic acidemia (HP:0002912)	3.49690076
6	Nephronophthisis (HP:0000090)	3.48578685
7	Genetic anticipation (HP:0003743)	3.34495891
8	Abnormality of the renal cortex (HP:0011035)	3.31553442
9	Abolished electroretinogram (ERG) (HP:0000550)	3.21577657
10	Molar tooth sign on MRI (HP:0002419)	3.05780077
11	Abnormality of midbrain morphology (HP:0002418)	3.05780077
12	Abnormality of the renal medulla (HP:0100957)	3.04721186
13	Progressive cerebellar ataxia (HP:0002073)	3.01708567
14	Keratoconus (HP:0000563)	2.86882866
15	Increased corneal curvature (HP:0100692)	2.86882866
16	Methylmalonic aciduria (HP:0012120)	2.84014671
17	Cystic liver disease (HP:0006706)	2.82198644
18	Renal cortical cysts (HP:0000803)	2.80671249
19	Congenital stationary night blindness (HP:0007642)	2.69144586
20	Furrowed tongue (HP:0000221)	2.65129564
21	Progressive inability to walk (HP:0002505)	2.61040383
22	Attenuation of retinal blood vessels (HP:0007843)	2.61014044
23	Focal motor seizures (HP:0011153)	2.56933018
24	Asplenia (HP:0001746)	2.55083129
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53234941
26	Severe visual impairment (HP:0001141)	2.52657207
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.51666705
28	Type II lissencephaly (HP:0007260)	2.50337806
29	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.50137034
30	Inability to walk (HP:0002540)	2.46638516
31	Agitation (HP:0000713)	2.44028800
32	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.41088481
33	Chronic hepatic failure (HP:0100626)	2.40784187
34	Gaze-evoked nystagmus (HP:0000640)	2.40172950
35	Congenital sensorineural hearing impairment (HP:0008527)	2.38134669
36	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36320000
37	Hemiparesis (HP:0001269)	2.34754882
38	Hamartoma of the eye (HP:0010568)	2.33001093
39	Conjunctival hamartoma (HP:0100780)	2.30007184
40	Tubular atrophy (HP:0000092)	2.29358994
41	Medial flaring of the eyebrow (HP:0010747)	2.27208912
42	Decreased central vision (HP:0007663)	2.25097540
43	Sclerocornea (HP:0000647)	2.21844090
44	Congenital, generalized hypertrichosis (HP:0004540)	2.20537625
45	Congenital hepatic fibrosis (HP:0002612)	2.18827877
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17520725
47	Amelogenesis imperfecta (HP:0000705)	2.17003548
48	Bony spicule pigmentary retinopathy (HP:0007737)	2.12281219
49	Anencephaly (HP:0002323)	2.08733676
50	3-Methylglutaconic aciduria (HP:0003535)	2.07400805
51	Abnormality of vitamin B metabolism (HP:0004340)	2.06927181
52	Hypothermia (HP:0002045)	2.04492156
53	Large for gestational age (HP:0001520)	2.04091046
54	Meningioma (HP:0002858)	1.95998032
55	Short tibia (HP:0005736)	1.95578042
56	Abnormality of DNA repair (HP:0003254)	1.95377283
57	Chorioretinal atrophy (HP:0000533)	1.93215099
58	Abnormal drinking behavior (HP:0030082)	1.92559171
59	Polydipsia (HP:0001959)	1.92559171
60	Hyperventilation (HP:0002883)	1.92422207
61	Homocystinuria (HP:0002156)	1.92328608
62	Abnormality of homocysteine metabolism (HP:0010919)	1.92328608
63	Hepatocellular necrosis (HP:0001404)	1.90932228
64	Hypoplasia of the pons (HP:0012110)	1.89795658
65	Mitochondrial inheritance (HP:0001427)	1.89264645
66	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.88801918
67	Confusion (HP:0001289)	1.87298964
68	Small hand (HP:0200055)	1.84629600
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.84187503
70	Intestinal atresia (HP:0011100)	1.81305129
71	Increased CSF lactate (HP:0002490)	1.81188504
72	Carpal bone hypoplasia (HP:0001498)	1.80574206
73	Abnormality of the pons (HP:0007361)	1.80568416
74	Oligohydramnios (HP:0001562)	1.79926633
75	Optic nerve hypoplasia (HP:0000609)	1.79694834
76	Hypoproteinemia (HP:0003075)	1.78503705
77	Male pseudohermaphroditism (HP:0000037)	1.78419922
78	Goiter (HP:0000853)	1.77847589
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77317154
80	Genital tract atresia (HP:0001827)	1.76780384
81	Porencephaly (HP:0002132)	1.76172451
82	Tinnitus (HP:0000360)	1.75716750
83	IgG deficiency (HP:0004315)	1.75577415
84	Focal seizures (HP:0007359)	1.74200579
85	Fibular aplasia (HP:0002990)	1.73406769
86	Enlarged kidneys (HP:0000105)	1.73133742
87	Abnormal albumin level (HP:0012116)	1.71076094
88	Hypoalbuminemia (HP:0003073)	1.71076094
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69644025
90	Neoplasm of the adrenal cortex (HP:0100641)	1.69274157
91	Hepatic necrosis (HP:0002605)	1.69010405
92	Progressive macrocephaly (HP:0004481)	1.68808592
93	Vaginal atresia (HP:0000148)	1.68762518
94	Thyroid-stimulating hormone excess (HP:0002925)	1.68090625
95	Absent speech (HP:0001344)	1.68051013
96	Abnormality of chromosome stability (HP:0003220)	1.67601781
97	Congenital primary aphakia (HP:0007707)	1.66167624
98	Abnormality of the ileum (HP:0001549)	1.65729563
99	Hematochezia (HP:0002573)	1.65706425
100	Type I transferrin isoform profile (HP:0003642)	1.64273256

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.21920722
2	ADRBK2	3.23456602
3	STK38L	3.20103838
4	GRK1	3.07953394
5	MAP4K2	2.79945833
6	ZAK	2.65444739
7	LATS1	2.63405275
8	BMPR1B	2.52862091
9	ACVR1B	2.47535325
10	TAOK3	2.44099096
11	WNK3	2.27646140
12	NUAK1	2.25855971
13	PINK1	2.11432935
14	TXK	1.93458393
15	TAF1	1.68279632
16	WNK4	1.59134985
17	EIF2AK3	1.55434395
18	TLK1	1.51575982
19	TNIK	1.46633708
20	DAPK2	1.38039965
21	MAP3K4	1.36019068
22	OXSR1	1.35939750
23	MAPK13	1.35378308
24	TIE1	1.29054367
25	STK39	1.27006195
26	GRK7	1.23534701
27	CASK	1.18554549
28	NLK	1.17843051
29	PLK2	1.09480904
30	PAK3	1.09012180
31	INSRR	1.08962776
32	ADRBK1	1.08933241
33	BRSK2	1.07230753
34	MST4	1.04363344
35	CSNK1A1L	1.03661325
36	VRK2	1.03424948
37	MAP2K6	0.99076738
38	GRK5	0.98914860
39	VRK1	0.97670398
40	CSNK1G1	0.95856789
41	CSNK1G2	0.95655187
42	FGFR2	0.95294918
43	CSNK1G3	0.92714012
44	PRKCE	0.91078143
45	MKNK2	0.88776850
46	STK3	0.88242487
47	PRKD2	0.83639576
48	TRIM28	0.83514217
49	IKBKB	0.83070865
50	MAP2K2	0.80672177
51	TEC	0.80527549
52	PTK2B	0.79714386
53	CAMKK2	0.78502121
54	PRKCG	0.75655920
55	STK38	0.62118937
56	PRKD3	0.60577270
57	FER	0.59598873
58	MAP2K7	0.58426287
59	PIK3CG	0.58197661
60	STK16	0.57874191
61	PRKCI	0.57567587
62	PLK3	0.56267503
63	EPHA3	0.54538101
64	GRK6	0.52646227
65	DYRK2	0.51348041
66	CSNK1A1	0.48521532
67	PRKAA2	0.45889069
68	STK11	0.45289870
69	MUSK	0.44290980
70	TGFBR2	0.44033630
71	MAPKAPK3	0.43766830
72	NEK1	0.43734782
73	MAP2K1	0.42430917
74	EIF2AK2	0.41949884
75	LATS2	0.41242597
76	NME1	0.39367497
77	CAMK2A	0.39243036
78	CSNK1D	0.39052305
79	PRKACA	0.38109559
80	ABL1	0.38003818
81	TNK2	0.37819112
82	CDK3	0.37513952
83	RPS6KA5	0.37397234
84	NTRK3	0.36432508
85	ITK	0.35181402
86	PRKCH	0.34814497
87	ERBB3	0.34458676
88	PRKCQ	0.33295816
89	TGFBR1	0.33046517
90	NEK9	0.32081775
91	PHKG1	0.31700084
92	PHKG2	0.31700084
93	IGF1R	0.30941979
94	PRKD1	0.30201106
95	NEK2	0.28777244
96	IKBKE	0.27638913
97	PRKCA	0.26357790
98	PRKCZ	0.25340241
99	MAPKAPK5	0.25114776
100	PLK1	0.24951242

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.10563628
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.69922078
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.56196844
4	Homologous recombination_Homo sapiens_hsa03440	2.51236856
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36512037
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.31378537
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.30146830
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16185525
9	Nicotine addiction_Homo sapiens_hsa05033	2.14699999
10	Protein export_Homo sapiens_hsa03060	2.13019779
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08204178
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.94856301
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.93810605
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.92507341
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.92111896
16	Butanoate metabolism_Homo sapiens_hsa00650	1.87071092
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.82926697
18	Basal transcription factors_Homo sapiens_hsa03022	1.81674413
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72912563
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62509281
21	Morphine addiction_Homo sapiens_hsa05032	1.57645656
22	Taste transduction_Homo sapiens_hsa04742	1.56090137
23	One carbon pool by folate_Homo sapiens_hsa00670	1.50229999
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.45898352
25	Sulfur metabolism_Homo sapiens_hsa00920	1.45884524
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.45448087
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44310660
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40887267
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.39785054
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.35260790
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32659382
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29317905
33	Parkinsons disease_Homo sapiens_hsa05012	1.29221458
34	RNA polymerase_Homo sapiens_hsa03020	1.19345945
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16439386
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11608522
37	Insulin secretion_Homo sapiens_hsa04911	1.10882279
38	Olfactory transduction_Homo sapiens_hsa04740	1.10602494
39	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10344258
40	Peroxisome_Homo sapiens_hsa04146	1.06765751
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05957528
42	Propanoate metabolism_Homo sapiens_hsa00640	1.05947743
43	Retinol metabolism_Homo sapiens_hsa00830	1.05814718
44	RNA degradation_Homo sapiens_hsa03018	1.04101620
45	Glycerolipid metabolism_Homo sapiens_hsa00561	1.02435503
46	Serotonergic synapse_Homo sapiens_hsa04726	1.02274633
47	GABAergic synapse_Homo sapiens_hsa04727	1.02124144
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02050111
49	ABC transporters_Homo sapiens_hsa02010	1.00950908
50	Sphingolipid metabolism_Homo sapiens_hsa00600	0.99529315
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98314985
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96656156
53	Caffeine metabolism_Homo sapiens_hsa00232	0.94996674
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.93918483
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92435345
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87308846
57	Regulation of autophagy_Homo sapiens_hsa04140	0.86122678
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86007564
59	Alzheimers disease_Homo sapiens_hsa05010	0.83667680
60	Huntingtons disease_Homo sapiens_hsa05016	0.82438540
61	Circadian entrainment_Homo sapiens_hsa04713	0.82016351
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81989935
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81733077
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.80589190
65	Histidine metabolism_Homo sapiens_hsa00340	0.78627847
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75421964
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75348127
68	Salivary secretion_Homo sapiens_hsa04970	0.72956985
69	Proteasome_Homo sapiens_hsa03050	0.72556683
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.71789811
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71755577
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.68401735
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66151300
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65902567
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63130543
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.62136425
77	Circadian rhythm_Homo sapiens_hsa04710	0.59744098
78	Fatty acid degradation_Homo sapiens_hsa00071	0.56899803
79	Metabolic pathways_Homo sapiens_hsa01100	0.52948639
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52653261
81	Melanoma_Homo sapiens_hsa05218	0.52230838
82	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.50046999
83	Purine metabolism_Homo sapiens_hsa00230	0.49369016
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.49042151
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.47454294
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46985223
87	Asthma_Homo sapiens_hsa05310	0.46802134
88	Mineral absorption_Homo sapiens_hsa04978	0.46577492
89	Renin secretion_Homo sapiens_hsa04924	0.45563078
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45422170
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39506840
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36371399
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34792634
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34784442
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.34209468
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.31909278
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31791499
98	Long-term depression_Homo sapiens_hsa04730	0.31770060
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31759256
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.30144445

RPS2P45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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