RPS2P46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.81514425
2viral transcription (GO:0019083)6.91878193
3translational termination (GO:0006415)6.57993840
4ribosomal small subunit biogenesis (GO:0042274)6.47645400
5translational elongation (GO:0006414)5.89677134
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.55161829
7cotranslational protein targeting to membrane (GO:0006613)5.40567897
8protein targeting to ER (GO:0045047)5.39606753
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.16188994
10viral life cycle (GO:0019058)5.15261228
11maturation of SSU-rRNA (GO:0030490)5.12422287
12protein localization to endoplasmic reticulum (GO:0070972)5.10180083
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.09542654
14cellular protein complex disassembly (GO:0043624)4.97600179
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.66811112
16translational initiation (GO:0006413)4.60977727
17DNA deamination (GO:0045006)4.54137917
18ribosomal large subunit biogenesis (GO:0042273)4.28010037
19protein complex disassembly (GO:0043241)4.25751358
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.17741239
21macromolecular complex disassembly (GO:0032984)3.97217135
22translation (GO:0006412)3.87527156
23pyrimidine nucleotide catabolic process (GO:0006244)3.85094382
24ribonucleoprotein complex biogenesis (GO:0022613)3.79303308
25pseudouridine synthesis (GO:0001522)3.78673854
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67441955
27ATP synthesis coupled proton transport (GO:0015986)3.67441955
28nuclear-transcribed mRNA catabolic process (GO:0000956)3.64350004
29protein targeting to membrane (GO:0006612)3.58058390
30pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.57844881
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52261366
32cellular component biogenesis (GO:0044085)3.44396100
33mRNA catabolic process (GO:0006402)3.43206924
34protein complex biogenesis (GO:0070271)3.41071167
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41068375
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40096480
37deoxyribonucleotide catabolic process (GO:0009264)3.37530869
38ncRNA 3-end processing (GO:0043628)3.36793642
39cytidine deamination (GO:0009972)3.36697528
40cytidine metabolic process (GO:0046087)3.36697528
41cytidine catabolic process (GO:0006216)3.36697528
42positive thymic T cell selection (GO:0045059)3.35679494
43deoxyribose phosphate catabolic process (GO:0046386)3.34863993
44base-excision repair, AP site formation (GO:0006285)3.29577909
45purine nucleotide salvage (GO:0032261)3.29325155
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24749365
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24749365
48metallo-sulfur cluster assembly (GO:0031163)3.24629520
49iron-sulfur cluster assembly (GO:0016226)3.24629520
50rRNA processing (GO:0006364)3.24323598
51regulation of mitochondrial translation (GO:0070129)3.21677159
52RNA catabolic process (GO:0006401)3.20969809
53rRNA metabolic process (GO:0016072)3.17509177
54chaperone-mediated protein transport (GO:0072321)3.16468984
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13415534
56mitochondrial respiratory chain complex assembly (GO:0033108)3.10420309
57GTP biosynthetic process (GO:0006183)3.06176614
58positive regulation of B cell differentiation (GO:0045579)3.02222633
59formation of translation preinitiation complex (GO:0001731)2.98339829
60negative T cell selection (GO:0043383)2.95788651
61positive regulation of gamma-delta T cell activation (GO:0046645)2.95621280
62positive regulation of T cell apoptotic process (GO:0070234)2.93847203
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.93430361
64NADH dehydrogenase complex assembly (GO:0010257)2.93430361
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93430361
66UTP biosynthetic process (GO:0006228)2.92746190
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91049771
68actin nucleation (GO:0045010)2.90822392
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.88736915
70negative regulation of B cell apoptotic process (GO:0002903)2.88284379
71respiratory electron transport chain (GO:0022904)2.87533350
72positive T cell selection (GO:0043368)2.87361538
73nucleotide salvage (GO:0043173)2.85123006
74pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85122801
75positive regulation of prostaglandin secretion (GO:0032308)2.84660024
76cytochrome complex assembly (GO:0017004)2.83321639
77electron transport chain (GO:0022900)2.82536569
78UTP metabolic process (GO:0046051)2.78737103
79rRNA modification (GO:0000154)2.78247063
80guanosine-containing compound biosynthetic process (GO:1901070)2.78027449
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77134064
82pyrimidine ribonucleoside catabolic process (GO:0046133)2.76163830
83negative thymic T cell selection (GO:0045060)2.74987415
84purine deoxyribonucleotide catabolic process (GO:0009155)2.73591466
85regulation of B cell differentiation (GO:0045577)2.73399376
86ribosome biogenesis (GO:0042254)2.73249056
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.72998795
88termination of RNA polymerase III transcription (GO:0006386)2.72998795
89deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.72615169
90thymic T cell selection (GO:0045061)2.72613499
912-deoxyribonucleotide metabolic process (GO:0009394)2.70853952
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68877188
93maturation of 5.8S rRNA (GO:0000460)2.68258310
94regulation of B cell receptor signaling pathway (GO:0050855)2.64962594
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62728329
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61313640
97regulation of gamma-delta T cell differentiation (GO:0045586)2.60932331
98deoxyribose phosphate metabolic process (GO:0019692)2.58721561
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57910959
100leukocyte aggregation (GO:0070486)2.57901848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.59463044
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54866986
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.54561182
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.32508077
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30440658
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20808104
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01400931
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.81390358
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78662787
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.77250681
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64585305
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59753901
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.57941476
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56850956
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.37947125
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31845416
17E2F7_22180533_ChIP-Seq_HELA_Human2.23813698
18VDR_23849224_ChIP-Seq_CD4+_Human2.18920195
19XRN2_22483619_ChIP-Seq_HELA_Human2.15423192
20FOXP3_21729870_ChIP-Seq_TREG_Human2.11625724
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09136965
22VDR_21846776_ChIP-Seq_THP-1_Human2.04570739
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03506341
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01095338
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00048486
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97356351
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93768631
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93524465
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85882181
30TTF2_22483619_ChIP-Seq_HELA_Human1.82681527
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79843096
32CIITA_25753668_ChIP-Seq_RAJI_Human1.78006828
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77553056
34MYC_22102868_ChIP-Seq_BL_Human1.76960486
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69790950
36GABP_19822575_ChIP-Seq_HepG2_Human1.66510349
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.66089711
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65806637
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65432870
40MYB_26560356_Chip-Seq_TH2_Human1.65309571
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64980165
42MAF_26560356_Chip-Seq_TH2_Human1.59671446
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.57815610
44BCL6_27268052_Chip-Seq_Bcells_Human1.57077438
45UTX_26944678_Chip-Seq_JUKART_Human1.53771235
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.50587581
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.49846129
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49546101
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48665550
50DCP1A_22483619_ChIP-Seq_HELA_Human1.47650632
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.45502086
52MAF_26560356_Chip-Seq_TH1_Human1.45063867
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42278298
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41045592
55SPI1_23547873_ChIP-Seq_NB4_Human1.38968325
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38392638
57CTCF_26484167_Chip-Seq_Bcells_Mouse1.35120343
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.33917555
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32737866
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30858971
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30782744
62MYB_26560356_Chip-Seq_TH1_Human1.29328246
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28557355
64P68_20966046_ChIP-Seq_HELA_Human1.28336346
65SCL_19346495_ChIP-Seq_HPC-7_Human1.26980658
66CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25882734
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25799169
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25259150
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23658512
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22795506
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20787069
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20221612
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20074814
74BCOR_27268052_Chip-Seq_Bcells_Human1.19792953
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18877902
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15392139
77MYC_18940864_ChIP-ChIP_HL60_Human1.14264769
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14068796
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13851796
80E2F1_20622854_ChIP-Seq_HELA_Human1.13756688
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12451558
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.11751837
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08043932
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.07376251
85P300_27268052_Chip-Seq_Bcells_Human1.06940535
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06849071
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04478961
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03589564
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03573906
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03378174
91VDR_24763502_ChIP-Seq_THP-1_Human1.02951859
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02925657
93KDM5A_27292631_Chip-Seq_BREAST_Human1.02800142
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02721760
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.02303815
96CTCF_20526341_ChIP-Seq_ESCs_Human1.00262133
97SA1_27219007_Chip-Seq_Bcells_Human1.00076155
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99965224
99PHF8_20622854_ChIP-Seq_HELA_Human0.97349000
100STAT1_20625510_ChIP-Seq_HELA_Human0.93433794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.65532470
2MP0005671_abnormal_response_to3.48263442
3MP0009333_abnormal_splenocyte_physiolog3.39380951
4MP0003763_abnormal_thymus_physiology3.16822251
5MP0001835_abnormal_antigen_presentation2.92691757
6MP0003436_decreased_susceptibility_to2.62084457
7MP0001873_stomach_inflammation2.50927635
8MP0005000_abnormal_immune_tolerance2.46458675
9MP0001800_abnormal_humoral_immune2.29100075
10MP0002148_abnormal_hypersensitivity_rea2.24230265
11MP0006292_abnormal_olfactory_placode2.16152562
12MP0009785_altered_susceptibility_to2.15570146
13MP0000685_abnormal_immune_system2.14185174
14MP0003806_abnormal_nucleotide_metabolis2.13695309
15MP0002132_abnormal_respiratory_system2.10067376
16MP0002723_abnormal_immune_serum2.06905247
17MP0002163_abnormal_gland_morphology2.06650893
18MP0002420_abnormal_adaptive_immunity2.03322834
19MP0002398_abnormal_bone_marrow2.00966218
20MP0001819_abnormal_immune_cell1.99093595
21MP0005025_abnormal_response_to1.96769094
22MP0002138_abnormal_hepatobiliary_system1.93287739
23MP0000678_abnormal_parathyroid_gland1.91226167
24MP0003866_abnormal_defecation1.87521231
25MP0001790_abnormal_immune_system1.82533129
26MP0005387_immune_system_phenotype1.82533129
27MP0002452_abnormal_antigen_presenting1.81883327
28MP0000703_abnormal_thymus_morphology1.79159554
29MP0000716_abnormal_immune_system1.77745351
30MP0009278_abnormal_bone_marrow1.77561385
31MP0003786_premature_aging1.67490935
32MP0002405_respiratory_system_inflammati1.66646246
33MP0000689_abnormal_spleen_morphology1.65957506
34MP0005075_abnormal_melanosome_morpholog1.65063243
35MP0008995_early_reproductive_senescence1.64690715
36MP0002722_abnormal_immune_system1.64423838
37MP0003724_increased_susceptibility_to1.61035632
38MP0002429_abnormal_blood_cell1.55097469
39MP0003646_muscle_fatigue1.54419304
40MP0010155_abnormal_intestine_physiology1.46976051
41MP0004147_increased_porphyrin_level1.46412299
42MP0002160_abnormal_reproductive_system1.45034452
43MP0000465_gastrointestinal_hemorrhage1.43781525
44MP0006036_abnormal_mitochondrial_physio1.43245662
45MP0002419_abnormal_innate_immunity1.38010043
46MP0002396_abnormal_hematopoietic_system1.37123727
47MP0001764_abnormal_homeostasis1.36885358
48MP0002277_abnormal_respiratory_mucosa1.35923169
49MP0005464_abnormal_platelet_physiology1.34430416
50MP0005389_reproductive_system_phenotype1.30758438
51MP0008058_abnormal_DNA_repair1.29585661
52MP0001845_abnormal_inflammatory_respons1.28925788
53MP0000372_irregular_coat_pigmentation1.27296868
54MP0000490_abnormal_crypts_of1.25739343
55MP0003693_abnormal_embryo_hatching1.22905497
56MP0005645_abnormal_hypothalamus_physiol1.21550932
57MP0005646_abnormal_pituitary_gland1.19710993
58MP0000681_abnormal_thyroid_gland1.15450337
59MP0002653_abnormal_ependyma_morphology1.14972940
60MP0001919_abnormal_reproductive_system1.14581295
61MP0004145_abnormal_muscle_electrophysio1.12144345
62MP0003186_abnormal_redox_activity1.11860052
63MP0002019_abnormal_tumor_incidence1.10092899
64MP0008469_abnormal_protein_level1.09582607
65MP0002837_dystrophic_cardiac_calcinosis1.07448364
66MP0005084_abnormal_gallbladder_morpholo1.04152361
67MP0005451_abnormal_body_composition1.03064069
68MP0002234_abnormal_pharynx_morphology1.01146567
69MP0002095_abnormal_skin_pigmentation0.99757753
70MP0005397_hematopoietic_system_phenotyp0.98028157
71MP0001545_abnormal_hematopoietic_system0.98028157
72MP0001663_abnormal_digestive_system0.93763160
73MP0008872_abnormal_physiological_respon0.92653222
74MP0010094_abnormal_chromosome_stability0.91495851
75MP0001533_abnormal_skeleton_physiology0.91447061
76MP0002006_tumorigenesis0.91085380
77MP0002166_altered_tumor_susceptibility0.86729628
78MP0001188_hyperpigmentation0.86436357
79MP0004947_skin_inflammation0.85392550
80MP0009764_decreased_sensitivity_to0.85106417
81MP0006082_CNS_inflammation0.82672982
82MP0005379_endocrine/exocrine_gland_phen0.81905348
83MP0001348_abnormal_lacrimal_gland0.77869658
84MP0003111_abnormal_nucleus_morphology0.76937556
85MP0002933_joint_inflammation0.76320852
86MP0001881_abnormal_mammary_gland0.74944493
87MP0008789_abnormal_olfactory_epithelium0.72901865
88MP0005636_abnormal_mineral_homeostasis0.71167961
89MP0001661_extended_life_span0.69559253
90MP0000049_abnormal_middle_ear0.68632755
91MP0004957_abnormal_blastocyst_morpholog0.68310466
92MP0005360_urolithiasis0.66368400
93MP0003191_abnormal_cellular_cholesterol0.66187614
94MP0003878_abnormal_ear_physiology0.65245564
95MP0005377_hearing/vestibular/ear_phenot0.65245564
96MP0001853_heart_inflammation0.65010899
97MP0001905_abnormal_dopamine_level0.64769785
98MP0009765_abnormal_xenobiotic_induced0.64539495
99MP0000313_abnormal_cell_death0.64359599
100MP0002693_abnormal_pancreas_physiology0.64079247

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.53108557
2Abnormality of cells of the erythroid lineage (HP:0012130)4.17487879
3Aplastic anemia (HP:0001915)3.97882875
4Abnormal number of erythroid precursors (HP:0012131)3.94606536
5Panhypogammaglobulinemia (HP:0003139)3.88218695
6Mitochondrial inheritance (HP:0001427)3.85953874
7Increased intramyocellular lipid droplets (HP:0012240)3.82684224
8Abnormal mitochondria in muscle tissue (HP:0008316)3.77755252
9Acute necrotizing encephalopathy (HP:0006965)3.75951075
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.59618654
11Elevated erythrocyte sedimentation rate (HP:0003565)3.57670910
12Pallor (HP:0000980)3.55786977
13Macrocytic anemia (HP:0001972)3.54392067
14Severe combined immunodeficiency (HP:0004430)3.51255580
153-Methylglutaconic aciduria (HP:0003535)3.50450953
16Increased muscle lipid content (HP:0009058)3.46016920
17Abnormality of B cell number (HP:0010975)3.33360305
18Increased hepatocellular lipid droplets (HP:0006565)3.24599954
19Hepatocellular necrosis (HP:0001404)3.24385729
20Acute encephalopathy (HP:0006846)3.24361864
21Increased CSF lactate (HP:0002490)3.23642178
22Increased IgM level (HP:0003496)3.23430001
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.22990971
24B lymphocytopenia (HP:0010976)3.18416290
25IgG deficiency (HP:0004315)3.07449870
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02293105
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02293105
28Lipid accumulation in hepatocytes (HP:0006561)2.98487388
29Renal Fanconi syndrome (HP:0001994)2.98242960
30Progressive macrocephaly (HP:0004481)2.97978062
31Pancytopenia (HP:0001876)2.91407426
32Agammaglobulinemia (HP:0004432)2.89781263
33Hepatic necrosis (HP:0002605)2.87905803
34Abnormality of T cells (HP:0002843)2.82108823
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.78858742
36Microretrognathia (HP:0000308)2.73557724
37Combined immunodeficiency (HP:0005387)2.71450478
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68652080
39Abnormal rod and cone electroretinograms (HP:0008323)2.65363495
40Cerebral edema (HP:0002181)2.61710969
41Encephalitis (HP:0002383)2.59149176
42Respiratory difficulties (HP:0002880)2.55072523
43Stomatitis (HP:0010280)2.53869290
44Exertional dyspnea (HP:0002875)2.53170356
45Lactic acidosis (HP:0003128)2.48614783
46Abnormality of T cell physiology (HP:0011840)2.45355117
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43446546
48Increased serum lactate (HP:0002151)2.43075146
49Absent thumb (HP:0009777)2.40042651
50Chronic obstructive pulmonary disease (HP:0006510)2.38100141
51Obstructive lung disease (HP:0006536)2.38100141
52T lymphocytopenia (HP:0005403)2.37954609
53Thrombocytosis (HP:0001894)2.37735471
54Autoimmune hemolytic anemia (HP:0001890)2.37123530
55Abnormality of T cell number (HP:0011839)2.36237499
56Testicular atrophy (HP:0000029)2.35136067
57Granulocytopenia (HP:0001913)2.32909410
58Exercise intolerance (HP:0003546)2.32708160
59Abnormality of DNA repair (HP:0003254)2.31495997
60Recurrent fungal infections (HP:0002841)2.31008180
61Meningitis (HP:0001287)2.28481078
62Constricted visual fields (HP:0001133)2.25653919
63Abnormality of eosinophils (HP:0001879)2.24966968
64Dicarboxylic aciduria (HP:0003215)2.18821908
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18821908
66Myositis (HP:0100614)2.11873106
67Optic disc pallor (HP:0000543)2.09468690
68Microvesicular hepatic steatosis (HP:0001414)2.07989687
69Congenital stationary night blindness (HP:0007642)2.05910267
70Eosinophilia (HP:0001880)2.03323840
71Reduced antithrombin III activity (HP:0001976)2.02189986
72Chronic mucocutaneous candidiasis (HP:0002728)2.01880134
73Recurrent cutaneous fungal infections (HP:0011370)2.01880134
74Aplasia/Hypoplasia of the thymus (HP:0010515)2.01162529
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00841333
76Recurrent viral infections (HP:0004429)2.00068115
77Hypertensive crisis (HP:0100735)1.99712019
78Neutropenia (HP:0001875)1.99522452
79Abnormal hemoglobin (HP:0011902)1.98468221
80Pustule (HP:0200039)1.98089426
81Mediastinal lymphadenopathy (HP:0100721)1.97265780
82Abnormality of the heme biosynthetic pathway (HP:0010472)1.94726085
83IgM deficiency (HP:0002850)1.92759197
84Cleft eyelid (HP:0000625)1.91979772
85Gastrointestinal infarctions (HP:0005244)1.91215616
86Hypoproteinemia (HP:0003075)1.91139349
87Muscle fiber atrophy (HP:0100295)1.90018501
88Gastrointestinal inflammation (HP:0004386)1.87535908
89Abnormality of the prostate (HP:0008775)1.81462380
90Respiratory failure (HP:0002878)1.79906594
91Hypergammaglobulinemia (HP:0010702)1.79028273
92Leukocytosis (HP:0001974)1.78812361
93Lethargy (HP:0001254)1.75796026
94Petechiae (HP:0000967)1.75264633
95Cerebral palsy (HP:0100021)1.73370724
96Hyperglycinemia (HP:0002154)1.72875300
97Thyroiditis (HP:0100646)1.72426548
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71969234
99Severe visual impairment (HP:0001141)1.71639089
100Inflammation of the large intestine (HP:0002037)1.69730680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.11712859
2VRK24.02151893
3BCKDK3.99712258
4MAP4K13.81044137
5TESK23.63977378
6NME23.23491504
7CDK192.88765835
8TXK2.79467740
9PASK2.52429371
10MAP3K112.04842253
11GRK62.03361849
12TAOK31.96570677
13KIT1.70560580
14SCYL21.70101367
15ITK1.63122692
16JAK31.62902024
17ZAK1.56824836
18STK161.56634986
19IKBKB1.53056210
20VRK11.46378160
21NUAK11.40113078
22TLK11.37272602
23SYK1.35604806
24CDK81.35554050
25SMG11.34679499
26PIM21.30384994
27BTK1.29596487
28FES1.28642426
29RPS6KA41.22120128
30MAP4K21.17343555
31MAP2K31.16538047
32TBK11.16122408
33ADRBK21.16113011
34RPS6KB21.15998889
35BUB11.10292640
36TEC1.08458278
37IKBKE1.08363145
38TNK21.08128322
39TAOK21.07456583
40CDC71.03293604
41LCK1.03025508
42PIM11.02376754
43GRK11.01197946
44LIMK10.95223840
45IRAK40.91926610
46RPS6KA50.87650523
47TESK10.87557218
48CDK40.87500519
49RPS6KA60.84002801
50AURKA0.80307733
51ABL20.79944566
52MUSK0.79855180
53CAMKK20.79711945
54DAPK10.79633964
55LYN0.79608368
56NME10.74148915
57CAMKK10.73759687
58PRKCQ0.72817255
59MATK0.71228147
60ZAP700.70779838
61LRRK20.70016524
62DYRK20.69721349
63DAPK30.69545989
64RPS6KC10.67399760
65RPS6KL10.67399760
66PIK3CG0.67284882
67FLT30.65284783
68ATR0.65251352
69RIPK40.63888745
70MAPKAPK30.58987071
71CSK0.58351181
72EIF2AK10.57671995
73MAP2K20.57176993
74CSF1R0.56397561
75ILK0.55087729
76CSNK2A20.55069203
77PINK10.54342676
78MAP2K60.54100798
79ERN10.53908117
80NEK20.51380215
81HCK0.50717978
82PRKCD0.49898719
83CSNK2A10.46639406
84BMPR20.45293332
85AURKB0.44713376
86TIE10.42680761
87MAP3K140.41999360
88CDK70.41424347
89MAPK70.41016899
90EIF2AK30.40818486
91CSNK1G30.39878810
92PRKCI0.38175754
93CHEK20.36153686
94TAF10.36070304
95PLK40.35993289
96CSNK1G10.32968126
97PAK10.32003348
98STK40.31553118
99SIK20.30935878
100OBSCN0.28834879

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.23251028
2Primary immunodeficiency_Homo sapiens_hsa053403.80654285
3Oxidative phosphorylation_Homo sapiens_hsa001903.06923434
4Proteasome_Homo sapiens_hsa030503.01381569
5DNA replication_Homo sapiens_hsa030302.69212589
6Parkinsons disease_Homo sapiens_hsa050122.68322334
7Allograft rejection_Homo sapiens_hsa053302.56970097
8RNA polymerase_Homo sapiens_hsa030202.53843633
9Sulfur relay system_Homo sapiens_hsa041222.47315163
10Graft-versus-host disease_Homo sapiens_hsa053322.47084576
11Base excision repair_Homo sapiens_hsa034102.40803791
12Autoimmune thyroid disease_Homo sapiens_hsa053202.35250895
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13534344
14Pyrimidine metabolism_Homo sapiens_hsa002402.06414941
15Antigen processing and presentation_Homo sapiens_hsa046121.97569371
16Type I diabetes mellitus_Homo sapiens_hsa049401.84056571
17Asthma_Homo sapiens_hsa053101.78495742
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78247464
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.74526100
20Huntingtons disease_Homo sapiens_hsa050161.73854028
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69930410
22One carbon pool by folate_Homo sapiens_hsa006701.58712467
23Spliceosome_Homo sapiens_hsa030401.58277543
24Mismatch repair_Homo sapiens_hsa034301.55809242
25Hematopoietic cell lineage_Homo sapiens_hsa046401.55023991
26Alzheimers disease_Homo sapiens_hsa050101.54850772
27Homologous recombination_Homo sapiens_hsa034401.50393874
28RNA degradation_Homo sapiens_hsa030181.34831722
29Nucleotide excision repair_Homo sapiens_hsa034201.30282294
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28976676
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27083138
32Fanconi anemia pathway_Homo sapiens_hsa034601.22492143
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20119143
34Purine metabolism_Homo sapiens_hsa002301.17742685
35RNA transport_Homo sapiens_hsa030131.16576151
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.16080472
37T cell receptor signaling pathway_Homo sapiens_hsa046601.04753576
38Viral myocarditis_Homo sapiens_hsa054161.00717499
39Cardiac muscle contraction_Homo sapiens_hsa042601.00410978
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00315937
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90506923
42Rheumatoid arthritis_Homo sapiens_hsa053230.89833356
43Herpes simplex infection_Homo sapiens_hsa051680.88026664
44Leishmaniasis_Homo sapiens_hsa051400.82614551
45Linoleic acid metabolism_Homo sapiens_hsa005910.78636237
46Epstein-Barr virus infection_Homo sapiens_hsa051690.78570643
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.77285412
48Peroxisome_Homo sapiens_hsa041460.77185354
49Measles_Homo sapiens_hsa051620.74495636
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73713537
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71490664
52Regulation of autophagy_Homo sapiens_hsa041400.66243599
53Arachidonic acid metabolism_Homo sapiens_hsa005900.63718828
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60146771
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.59130055
56Malaria_Homo sapiens_hsa051440.58480323
57Pentose phosphate pathway_Homo sapiens_hsa000300.58309182
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57644160
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52729542
60Metabolic pathways_Homo sapiens_hsa011000.52538744
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52214970
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52155555
63Sulfur metabolism_Homo sapiens_hsa009200.52081003
64Protein export_Homo sapiens_hsa030600.51303387
65HTLV-I infection_Homo sapiens_hsa051660.49123441
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47975694
67Phototransduction_Homo sapiens_hsa047440.47834910
68Systemic lupus erythematosus_Homo sapiens_hsa053220.47500866
69Shigellosis_Homo sapiens_hsa051310.44760041
70Folate biosynthesis_Homo sapiens_hsa007900.44404763
71Nitrogen metabolism_Homo sapiens_hsa009100.43996743
72Tyrosine metabolism_Homo sapiens_hsa003500.43927818
73Selenocompound metabolism_Homo sapiens_hsa004500.43818610
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42712614
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42577258
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42380186
77mRNA surveillance pathway_Homo sapiens_hsa030150.39368486
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38951125
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38204048
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37840722
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36345435
82Glutathione metabolism_Homo sapiens_hsa004800.33980615
83B cell receptor signaling pathway_Homo sapiens_hsa046620.33730132
84Biosynthesis of amino acids_Homo sapiens_hsa012300.32795204
85Olfactory transduction_Homo sapiens_hsa047400.32508084
86Basal transcription factors_Homo sapiens_hsa030220.30875497
87Ether lipid metabolism_Homo sapiens_hsa005650.30405967
88Fatty acid elongation_Homo sapiens_hsa000620.27400205
89Caffeine metabolism_Homo sapiens_hsa002320.27182760
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26664485
91Non-homologous end-joining_Homo sapiens_hsa034500.23668076
92Osteoclast differentiation_Homo sapiens_hsa043800.23488721
93Staphylococcus aureus infection_Homo sapiens_hsa051500.22203551
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22106069
95Phenylalanine metabolism_Homo sapiens_hsa003600.21688084
96Influenza A_Homo sapiens_hsa051640.20660442
97African trypanosomiasis_Homo sapiens_hsa051430.19662586
98Tuberculosis_Homo sapiens_hsa051520.18778704
99Legionellosis_Homo sapiens_hsa051340.18626164
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16730795

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