ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.40714591
2	ribosomal small subunit assembly (GO:0000028)	9.05708473
3	translational termination (GO:0006415)	8.97039658
4	ribosomal small subunit biogenesis (GO:0042274)	8.93959413
5	maturation of SSU-rRNA (GO:0030490)	8.39802360
6	translational elongation (GO:0006414)	7.59479814
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.52989668
8	cotranslational protein targeting to membrane (GO:0006613)	7.42675556
9	protein targeting to ER (GO:0045047)	7.38017038
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.04504658
11	protein localization to endoplasmic reticulum (GO:0070972)	6.91166121
12	cellular protein complex disassembly (GO:0043624)	6.90091565
13	viral life cycle (GO:0019058)	6.68902165
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.63191186
15	translational initiation (GO:0006413)	6.12720934
16	chaperone-mediated protein transport (GO:0072321)	5.89771738
17	protein complex disassembly (GO:0043241)	5.84771231
18	ATP synthesis coupled proton transport (GO:0015986)	5.69150855
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.69150855
20	macromolecular complex disassembly (GO:0032984)	5.54249409
21	ribosomal large subunit biogenesis (GO:0042273)	5.52772412
22	protein neddylation (GO:0045116)	5.47021248
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.36853122
24	protein targeting to membrane (GO:0006612)	4.93012028
25	translation (GO:0006412)	4.86944492
26	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.56438635
27	ribonucleoprotein complex biogenesis (GO:0022613)	4.45821434
28	mRNA catabolic process (GO:0006402)	4.32885057
29	cellular component biogenesis (GO:0044085)	4.03927852
30	behavioral response to nicotine (GO:0035095)	4.01693212
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.98432223
32	RNA catabolic process (GO:0006401)	3.92984768
33	protein complex biogenesis (GO:0070271)	3.87993986
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.84810523
35	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.82615796
36	GTP biosynthetic process (GO:0006183)	3.79812580
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77120313
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77120313
39	NADH dehydrogenase complex assembly (GO:0010257)	3.77120313
40	respiratory electron transport chain (GO:0022904)	3.75504027
41	base-excision repair, AP site formation (GO:0006285)	3.73920235
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.73802945
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.73802945
44	electron transport chain (GO:0022900)	3.72680468
45	negative regulation of telomere maintenance (GO:0032205)	3.66068299
46	rRNA processing (GO:0006364)	3.51029472
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.50167428
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.48045113
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47377883
50	rRNA metabolic process (GO:0016072)	3.47234434
51	DNA deamination (GO:0045006)	3.45791377
52	ATP biosynthetic process (GO:0006754)	3.40805801
53	UTP biosynthetic process (GO:0006228)	3.40711389
54	establishment of protein localization to membrane (GO:0090150)	3.31597199
55	protein polyglutamylation (GO:0018095)	3.27738110
56	protein targeting (GO:0006605)	3.26756149
57	UTP metabolic process (GO:0046051)	3.13232476
58	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.12491223
59	ncRNA 3-end processing (GO:0043628)	3.09312921
60	establishment of protein localization to organelle (GO:0072594)	3.06218740
61	deoxyribonucleotide catabolic process (GO:0009264)	3.04528617
62	protein-cofactor linkage (GO:0018065)	3.04357285
63	pyrimidine nucleotide catabolic process (GO:0006244)	3.04267506
64	negative regulation of T cell differentiation in thymus (GO:0033085)	3.01929093
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.90575813
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89595418
67	response to pheromone (GO:0019236)	2.87344649
68	protein targeting to mitochondrion (GO:0006626)	2.85619880
69	positive regulation of T cell apoptotic process (GO:0070234)	2.82639239
70	cell proliferation in forebrain (GO:0021846)	2.81643598
71	guanosine-containing compound biosynthetic process (GO:1901070)	2.81496730
72	negative regulation of telomerase activity (GO:0051974)	2.80305078
73	deoxyribose phosphate catabolic process (GO:0046386)	2.79283997
74	purine deoxyribonucleotide catabolic process (GO:0009155)	2.76778398
75	establishment of protein localization to mitochondrion (GO:0072655)	2.76618784
76	CTP metabolic process (GO:0046036)	2.75140645
77	CTP biosynthetic process (GO:0006241)	2.75140645
78	regulation of mitochondrial translation (GO:0070129)	2.73723612
79	neuron fate determination (GO:0048664)	2.72797039
80	pseudouridine synthesis (GO:0001522)	2.71948842
81	regulation of telomerase activity (GO:0051972)	2.68566630
82	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67821417
83	positive regulation of respiratory burst (GO:0060267)	2.67786264
84	pattern specification involved in kidney development (GO:0061004)	2.66527463
85	nucleoside triphosphate biosynthetic process (GO:0009142)	2.66383704
86	spliceosomal complex assembly (GO:0000245)	2.65954071
87	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.64780973
88	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.63952650
89	hydrogen ion transmembrane transport (GO:1902600)	2.63349854
90	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.60732099
91	male meiosis I (GO:0007141)	2.58785295
92	rRNA modification (GO:0000154)	2.57717408
93	protein localization to membrane (GO:0072657)	2.57132682
94	termination of RNA polymerase III transcription (GO:0006386)	2.57043700
95	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.57043700
96	water-soluble vitamin biosynthetic process (GO:0042364)	2.55541789
97	proteasome assembly (GO:0043248)	2.55171859
98	positive regulation of fatty acid transport (GO:2000193)	2.54533928
99	axoneme assembly (GO:0035082)	2.53817476
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.52716003

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.14271747
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.97878510
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.81944275
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.56011313
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.15715852
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07878027
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.03996887
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.98217573
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.97661120
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.94280026
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.92588540
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57077623
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.30782871
14	VDR_22108803_ChIP-Seq_LS180_Human	2.28856754
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.25472053
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.09054548
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01836413
18	TTF2_22483619_ChIP-Seq_HELA_Human	2.00256957
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.00116109
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.97815887
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.94875445
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.91056974
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.87466184
24	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.85312688
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83268651
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.76305561
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75245822
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69734295
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63186776
30	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.62823860
31	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58395630
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46133114
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.45837286
34	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.44342151
35	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.42592822
36	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.42183931
37	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.41116926
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40563535
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39013672
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.37167432
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36096137
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.35840369
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32548848
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32383260
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31678597
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.30577649
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.29607282
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26732744
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25795052
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24525671
51	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.24416604
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24000419
53	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.21732375
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21636373
55	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20073269
56	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.19657935
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19259411
58	BCL6_27268052_Chip-Seq_Bcells_Human	1.18557197
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18546419
60	ERA_21632823_ChIP-Seq_H3396_Human	1.17352707
61	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.16797095
62	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.16469459
63	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.14277048
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14153088
65	AR_20517297_ChIP-Seq_VCAP_Human	1.11726930
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.11515133
67	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.11372015
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10536935
69	NCOR_22424771_ChIP-Seq_293T_Human	1.10521449
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10232126
71	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.08996295
72	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08600927
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07005022
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05502027
75	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04716035
76	EWS_26573619_Chip-Seq_HEK293_Human	1.02040173
77	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.01437638
78	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00510119
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00003788
80	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.99224398
81	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99017955
82	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98948469
83	SA1_27219007_Chip-Seq_Bcells_Human	0.98495011
84	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.93552772
85	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93164787
86	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.91871684
87	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.91473349
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.90411853
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.90411853
90	FUS_26573619_Chip-Seq_HEK293_Human	0.90160161
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.90145707
92	DCP1A_22483619_ChIP-Seq_HELA_Human	0.89841614
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89642860
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.88808106
95	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88633823
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.88124184
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88074896
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87689536
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.87313439
100	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.87306364

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.26011135
2	MP0006292_abnormal_olfactory_placode	4.62149307
3	MP0002653_abnormal_ependyma_morphology	3.15949917
4	MP0002163_abnormal_gland_morphology	3.09286657
5	MP0003136_yellow_coat_color	2.74146793
6	MP0004142_abnormal_muscle_tone	2.29257399
7	MP0002736_abnormal_nociception_after	2.29089448
8	MP0001968_abnormal_touch/_nociception	2.28460026
9	MP0001293_anophthalmia	2.23258338
10	MP0005646_abnormal_pituitary_gland	2.18053029
11	MP0000049_abnormal_middle_ear	2.00290209
12	MP0002160_abnormal_reproductive_system	1.90868036
13	MP0005551_abnormal_eye_electrophysiolog	1.88112351
14	MP0002138_abnormal_hepatobiliary_system	1.85052784
15	MP0008877_abnormal_DNA_methylation	1.81534369
16	MP0002837_dystrophic_cardiac_calcinosis	1.78671825
17	MP0003787_abnormal_imprinting	1.76815798
18	MP0003011_delayed_dark_adaptation	1.75546842
19	MP0000372_irregular_coat_pigmentation	1.74553218
20	MP0002938_white_spotting	1.74288701
21	MP0004885_abnormal_endolymph	1.74059549
22	MP0004145_abnormal_muscle_electrophysio	1.67927634
23	MP0000631_abnormal_neuroendocrine_gland	1.64634762
24	MP0004147_increased_porphyrin_level	1.63879983
25	MP0002638_abnormal_pupillary_reflex	1.56963167
26	MP0008789_abnormal_olfactory_epithelium	1.56843000
27	MP0001986_abnormal_taste_sensitivity	1.56755795
28	MP0001529_abnormal_vocalization	1.56407410
29	MP0005084_abnormal_gallbladder_morpholo	1.54325765
30	MP0005379_endocrine/exocrine_gland_phen	1.53011222
31	MP0008872_abnormal_physiological_respon	1.50334918
32	MP0005645_abnormal_hypothalamus_physiol	1.49986674
33	MP0005389_reproductive_system_phenotype	1.48186187
34	MP0005377_hearing/vestibular/ear_phenot	1.47739066
35	MP0003878_abnormal_ear_physiology	1.47739066
36	MP0003186_abnormal_redox_activity	1.45412946
37	MP0002277_abnormal_respiratory_mucosa	1.43401879
38	MP0005394_taste/olfaction_phenotype	1.43277941
39	MP0005499_abnormal_olfactory_system	1.43277941
40	MP0002102_abnormal_ear_morphology	1.40193936
41	MP0008058_abnormal_DNA_repair	1.38812814
42	MP0008875_abnormal_xenobiotic_pharmacok	1.38143061
43	MP0003122_maternal_imprinting	1.35645941
44	MP0001485_abnormal_pinna_reflex	1.26979353
45	MP0001905_abnormal_dopamine_level	1.24421694
46	MP0005174_abnormal_tail_pigmentation	1.23909852
47	MP0002876_abnormal_thyroid_physiology	1.23470012
48	MP0001440_abnormal_grooming_behavior	1.23377236
49	MP0005075_abnormal_melanosome_morpholog	1.17436580
50	MP0003123_paternal_imprinting	1.11962788
51	MP0002095_abnormal_skin_pigmentation	1.11803980
52	MP0005671_abnormal_response_to	1.09861133
53	MP0001764_abnormal_homeostasis	1.07583400
54	MP0002132_abnormal_respiratory_system	1.05748640
55	MP0005195_abnormal_posterior_eye	1.05206320
56	MP0003646_muscle_fatigue	1.05091462
57	MP0003567_abnormal_fetal_cardiomyocyte	1.04456515
58	MP0005423_abnormal_somatic_nervous	1.03654839
59	MP0003938_abnormal_ear_development	1.01273847
60	MP0001502_abnormal_circadian_rhythm	1.00879878
61	MP0002249_abnormal_larynx_morphology	0.99227769
62	MP0004742_abnormal_vestibular_system	0.97913844
63	MP0002234_abnormal_pharynx_morphology	0.97764979
64	MP0001188_hyperpigmentation	0.95062860
65	MP0000026_abnormal_inner_ear	0.93944919
66	MP0004133_heterotaxia	0.92943259
67	MP0002272_abnormal_nervous_system	0.92574516
68	MP0002233_abnormal_nose_morphology	0.91514418
69	MP0002752_abnormal_somatic_nervous	0.90439582
70	MP0009745_abnormal_behavioral_response	0.89310863
71	MP0002733_abnormal_thermal_nociception	0.88254853
72	MP0003937_abnormal_limbs/digits/tail_de	0.88180313
73	MP0000778_abnormal_nervous_system	0.86799642
74	MP0001873_stomach_inflammation	0.86598775
75	MP0006276_abnormal_autonomic_nervous	0.86453776
76	MP0001919_abnormal_reproductive_system	0.85533482
77	MP0003121_genomic_imprinting	0.85385366
78	MP0000566_synostosis	0.84399701
79	MP0004782_abnormal_surfactant_physiolog	0.83159486
80	MP0002210_abnormal_sex_determination	0.82608192
81	MP0006072_abnormal_retinal_apoptosis	0.82084549
82	MP0009250_abnormal_appendicular_skeleto	0.81497263
83	MP0002928_abnormal_bile_duct	0.81181674
84	MP0002557_abnormal_social/conspecific_i	0.80939829
85	MP0000678_abnormal_parathyroid_gland	0.76287580
86	MP0001963_abnormal_hearing_physiology	0.76038629
87	MP0005253_abnormal_eye_physiology	0.73341252
88	MP0001663_abnormal_digestive_system	0.72832948
89	MP0005391_vision/eye_phenotype	0.71397800
90	MP0010030_abnormal_orbit_morphology	0.71169034
91	MP0003718_maternal_effect	0.66962681
92	MP0006036_abnormal_mitochondrial_physio	0.66553979
93	MP0000955_abnormal_spinal_cord	0.66118592
94	MP0001970_abnormal_pain_threshold	0.65990552
95	MP0001286_abnormal_eye_development	0.65887000
96	MP0001145_abnormal_male_reproductive	0.64099841
97	MP0001929_abnormal_gametogenesis	0.63646632
98	MP0003698_abnormal_male_reproductive	0.63461879
99	MP0003693_abnormal_embryo_hatching	0.62951170
100	MP0003936_abnormal_reproductive_system	0.62685836

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.73677515
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.11155615
3	Macrocytic anemia (HP:0001972)	4.55622924
4	Abnormal number of erythroid precursors (HP:0012131)	4.10342774
5	Acute necrotizing encephalopathy (HP:0006965)	3.99763147
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.98965866
7	Pallor (HP:0000980)	3.89926699
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.74802865
9	Mitochondrial inheritance (HP:0001427)	3.62978033
10	Congenital stationary night blindness (HP:0007642)	3.52056436
11	Acute encephalopathy (HP:0006846)	3.41611479
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.34922694
13	Increased hepatocellular lipid droplets (HP:0006565)	3.30166398
14	Progressive macrocephaly (HP:0004481)	3.23176606
15	Increased CSF lactate (HP:0002490)	3.17536343
16	3-Methylglutaconic aciduria (HP:0003535)	3.12162946
17	Stenosis of the external auditory canal (HP:0000402)	3.10227544
18	Lipid accumulation in hepatocytes (HP:0006561)	3.09285755
19	Septo-optic dysplasia (HP:0100842)	3.08872538
20	Abnormality of midbrain morphology (HP:0002418)	2.98527170
21	Molar tooth sign on MRI (HP:0002419)	2.98527170
22	Pancreatic cysts (HP:0001737)	2.88593795
23	Absent thumb (HP:0009777)	2.85168393
24	Renal Fanconi syndrome (HP:0001994)	2.79860272
25	Absent/shortened dynein arms (HP:0200106)	2.79577188
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.79577188
27	Pancreatic fibrosis (HP:0100732)	2.78916422
28	Hepatocellular necrosis (HP:0001404)	2.78341226
29	Rib fusion (HP:0000902)	2.72576234
30	Increased intramyocellular lipid droplets (HP:0012240)	2.69102395
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.67201715
32	Colon cancer (HP:0003003)	2.61054136
33	Asplenia (HP:0001746)	2.60437371
34	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.57925779
35	Medial flaring of the eyebrow (HP:0010747)	2.51417763
36	Exertional dyspnea (HP:0002875)	2.50105918
37	Partial duplication of thumb phalanx (HP:0009944)	2.49966942
38	Hepatic necrosis (HP:0002605)	2.47565826
39	Pendular nystagmus (HP:0012043)	2.42651057
40	True hermaphroditism (HP:0010459)	2.41707478
41	Abnormal hemoglobin (HP:0011902)	2.40756943
42	Cerebral edema (HP:0002181)	2.36344902
43	Oligodactyly (hands) (HP:0001180)	2.35333945
44	Respiratory difficulties (HP:0002880)	2.31570230
45	Optic disc pallor (HP:0000543)	2.29869353
46	Increased muscle lipid content (HP:0009058)	2.27961786
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.27493226
48	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.27493226
49	Abolished electroretinogram (ERG) (HP:0000550)	2.25793888
50	Type II lissencephaly (HP:0007260)	2.23441803
51	Sclerocornea (HP:0000647)	2.21894032
52	Hypoplasia of the radius (HP:0002984)	2.19619570
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13441665
54	Aplastic anemia (HP:0001915)	2.12995123
55	Partial duplication of the phalanx of hand (HP:0009999)	2.12715313
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.12570176
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12570176
58	Constricted visual fields (HP:0001133)	2.11529012
59	Increased IgM level (HP:0003496)	2.10697967
60	Gait imbalance (HP:0002141)	2.07788152
61	Depressed nasal ridge (HP:0000457)	2.06624902
62	Congenital primary aphakia (HP:0007707)	2.06419405
63	Abnormality of macular pigmentation (HP:0008002)	2.05279223
64	Increased serum lactate (HP:0002151)	2.05160894
65	Abnormality of DNA repair (HP:0003254)	2.05094615
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03662694
67	Hypoplasia of the pons (HP:0012110)	2.02582207
68	Abnormal drinking behavior (HP:0030082)	2.01883736
69	Polydipsia (HP:0001959)	2.01883736
70	Abnormality of the renal cortex (HP:0011035)	2.00003512
71	Decreased central vision (HP:0007663)	1.97873508
72	Abnormal ciliary motility (HP:0012262)	1.93749802
73	Triphalangeal thumb (HP:0001199)	1.92534927
74	Lactic acidosis (HP:0003128)	1.91397994
75	Abnormality of the pons (HP:0007361)	1.89886003
76	Oligodactyly (HP:0012165)	1.88262183
77	Attenuation of retinal blood vessels (HP:0007843)	1.86249729
78	Nephronophthisis (HP:0000090)	1.86023213
79	Hyperglycinemia (HP:0002154)	1.86011504
80	Abnormality of the labia minora (HP:0012880)	1.83301923
81	Abnormality of alanine metabolism (HP:0010916)	1.82906086
82	Hyperalaninemia (HP:0003348)	1.82906086
83	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.82906086
84	Anophthalmia (HP:0000528)	1.82865559
85	Bile duct proliferation (HP:0001408)	1.79811559
86	Abnormal biliary tract physiology (HP:0012439)	1.79811559
87	Cystic liver disease (HP:0006706)	1.79424271
88	Chronic hepatic failure (HP:0100626)	1.79065171
89	Lethargy (HP:0001254)	1.78975479
90	Anencephaly (HP:0002323)	1.78473844
91	Respiratory failure (HP:0002878)	1.78168496
92	Abnormality of renal resorption (HP:0011038)	1.78072341
93	Nephrogenic diabetes insipidus (HP:0009806)	1.77597879
94	Glycosuria (HP:0003076)	1.77017201
95	Abnormality of urine glucose concentration (HP:0011016)	1.77017201
96	Optic nerve hypoplasia (HP:0000609)	1.75153156
97	Maternal diabetes (HP:0009800)	1.74949794
98	Renal cortical cysts (HP:0000803)	1.74691547
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74198850
100	Polyuria (HP:0000103)	1.70327693

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.05366018
2	STK16	3.16174525
3	VRK2	3.03857520
4	BCKDK	2.84116616
5	WNK4	2.78373566
6	TXK	2.58536885
7	GRK1	2.44945585
8	MAP4K2	2.40388965
9	NUAK1	2.33767672
10	ADRBK2	2.13861874
11	DAPK2	2.12903462
12	DYRK2	2.10379250
13	TIE1	2.07781576
14	PASK	1.82317203
15	KDR	1.75189111
16	NME2	1.72252346
17	TLK1	1.71377375
18	PINK1	1.64203890
19	KIT	1.62734505
20	PIK3CA	1.57327337
21	TAOK3	1.52537826
22	LRRK2	1.48066010
23	MAPKAPK5	1.47132022
24	BMPR1B	1.39817775
25	STK39	1.34924321
26	MAP4K1	1.31068219
27	TAF1	1.26438404
28	DAPK3	1.26190111
29	FRK	1.21027274
30	OXSR1	1.18862113
31	RPS6KA6	1.17023748
32	ABL2	1.10348765
33	VRK1	1.09789257
34	ZAK	1.07614930
35	RPS6KC1	0.95130718
36	RPS6KL1	0.95130718
37	MAP3K11	0.92829096
38	RPS6KB2	0.88671691
39	IKBKB	0.87368081
40	CAMKK2	0.85966119
41	ILK	0.83642213
42	CDC7	0.82334564
43	RPS6KA5	0.81953660
44	CAMKK1	0.81502048
45	CSNK2A2	0.80768939
46	PRKCQ	0.79896792
47	ADRBK1	0.79147236
48	CAMK1	0.78934842
49	TNIK	0.78806106
50	ITK	0.78111991
51	PIM2	0.76761057
52	MAPK15	0.75959707
53	PIM1	0.75711206
54	NEK2	0.75624868
55	EPHB2	0.75456183
56	PRKCI	0.75381470
57	NME1	0.75004393
58	MATK	0.74227752
59	WNK3	0.73451516
60	CHEK2	0.72444629
61	TRPM7	0.72096122
62	INSRR	0.72072101
63	PRKCG	0.70979220
64	AURKA	0.67237040
65	BTK	0.64089190
66	PLK1	0.60951005
67	LIMK1	0.60173292
68	CSNK2A1	0.59579537
69	AURKB	0.59487516
70	PDK2	0.58439305
71	SYK	0.58316074
72	PRKACA	0.56543350
73	CSNK1G3	0.56480304
74	MKNK1	0.55572753
75	TGFBR1	0.55093736
76	TEC	0.54371120
77	WNK1	0.53905553
78	MUSK	0.53707494
79	ATR	0.53673874
80	MARK3	0.53211747
81	MAP2K7	0.53070243
82	DAPK1	0.52704051
83	MAP3K4	0.52593364
84	CSNK1G1	0.51804377
85	PRKCD	0.50495785
86	HIPK2	0.49854995
87	CSNK1G2	0.49715415
88	PRKCZ	0.49547848
89	BRAF	0.47659832
90	PLK4	0.45952536
91	CSNK1A1	0.45655654
92	LCK	0.43565058
93	PAK3	0.43089725
94	STK11	0.42901078
95	MAP2K2	0.41734825
96	CSNK1E	0.40844896
97	PRKCA	0.40655974
98	RPS6KA1	0.40299330
99	NTRK2	0.39805335
100	OBSCN	0.39168885

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.72098711
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.03060840
3	Parkinsons disease_Homo sapiens_hsa05012	3.29629771
4	Huntingtons disease_Homo sapiens_hsa05016	2.37936377
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.27545142
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22565850
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21858739
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.20533994
9	Alzheimers disease_Homo sapiens_hsa05010	2.17188341
10	RNA polymerase_Homo sapiens_hsa03020	2.08750218
11	Proteasome_Homo sapiens_hsa03050	2.02991259
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01910311
13	Sulfur relay system_Homo sapiens_hsa04122	1.93005740
14	One carbon pool by folate_Homo sapiens_hsa00670	1.86161664
15	Phototransduction_Homo sapiens_hsa04744	1.81908428
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78688601
17	Basal transcription factors_Homo sapiens_hsa03022	1.63893285
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63131518
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62484996
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.59909667
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.55439287
22	Caffeine metabolism_Homo sapiens_hsa00232	1.49432738
23	Homologous recombination_Homo sapiens_hsa03440	1.47623804
24	Base excision repair_Homo sapiens_hsa03410	1.45187427
25	RNA degradation_Homo sapiens_hsa03018	1.43287530
26	Protein export_Homo sapiens_hsa03060	1.38419336
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34400439
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21281960
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.20662517
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.15774486
31	Spliceosome_Homo sapiens_hsa03040	1.09972431
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09096262
33	Folate biosynthesis_Homo sapiens_hsa00790	1.08364340
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.06602197
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.05624014
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04364344
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99445672
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99010848
39	Asthma_Homo sapiens_hsa05310	0.95610024
40	Allograft rejection_Homo sapiens_hsa05330	0.94863979
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90294082
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90237969
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89052212
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.88931798
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.88024816
46	RNA transport_Homo sapiens_hsa03013	0.85945159
47	DNA replication_Homo sapiens_hsa03030	0.83849732
48	Peroxisome_Homo sapiens_hsa04146	0.79043739
49	Purine metabolism_Homo sapiens_hsa00230	0.78129161
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77564332
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.77468837
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77161442
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75899397
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.72204380
55	Metabolic pathways_Homo sapiens_hsa01100	0.69602171
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67864072
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67412951
58	Nicotine addiction_Homo sapiens_hsa05033	0.66923776
59	Propanoate metabolism_Homo sapiens_hsa00640	0.65468181
60	Graft-versus-host disease_Homo sapiens_hsa05332	0.63233913
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61834244
62	Olfactory transduction_Homo sapiens_hsa04740	0.61792760
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61158912
64	Retinol metabolism_Homo sapiens_hsa00830	0.60835629
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60116535
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57819103
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57594948
68	Butanoate metabolism_Homo sapiens_hsa00650	0.57236037
69	Mismatch repair_Homo sapiens_hsa03430	0.54895545
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54248704
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53905658
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.53106562
73	Sulfur metabolism_Homo sapiens_hsa00920	0.52310413
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51889530
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51876049
76	Regulation of autophagy_Homo sapiens_hsa04140	0.49023369
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48720616
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48209482
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45891321
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.41688284
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41033705
82	Mineral absorption_Homo sapiens_hsa04978	0.39431663
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39150112
84	Fatty acid degradation_Homo sapiens_hsa00071	0.37682128
85	Antigen processing and presentation_Homo sapiens_hsa04612	0.37641160
86	Taste transduction_Homo sapiens_hsa04742	0.37250536
87	Morphine addiction_Homo sapiens_hsa05032	0.35112937
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31787671
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30668318
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29785798
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28227231
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27912326
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24022781
94	p53 signaling pathway_Homo sapiens_hsa04115	0.23873659
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.20686406
96	Fatty acid elongation_Homo sapiens_hsa00062	0.18756891
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.17972307
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.17366368
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.17091809
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.16422298

RPS2P48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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