RPS2P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.82270318
2viral transcription (GO:0019083)5.63405763
3ribosomal small subunit assembly (GO:0000028)5.40121773
4translational termination (GO:0006415)5.32676645
5translational elongation (GO:0006414)4.79863399
6formation of translation preinitiation complex (GO:0001731)4.74138840
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.72817725
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.54632457
9protein targeting to ER (GO:0045047)4.42364301
10cotranslational protein targeting to membrane (GO:0006613)4.40266287
11viral life cycle (GO:0019058)4.34967133
12maturation of SSU-rRNA (GO:0030490)4.33065828
13regulation of translational fidelity (GO:0006450)4.27143522
14DNA unwinding involved in DNA replication (GO:0006268)4.26038192
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23164482
16translational initiation (GO:0006413)4.22180114
17protein localization to endoplasmic reticulum (GO:0070972)4.11221100
18cellular protein complex disassembly (GO:0043624)4.10224769
19peptidyl-arginine omega-N-methylation (GO:0035247)4.05378812
20proline biosynthetic process (GO:0006561)4.03519235
21protein complex disassembly (GO:0043241)3.88668956
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80156772
23ribosomal large subunit biogenesis (GO:0042273)3.69491561
24DNA strand elongation involved in DNA replication (GO:0006271)3.66518946
25ribonucleoprotein complex biogenesis (GO:0022613)3.62363257
26macromolecular complex disassembly (GO:0032984)3.60479856
27DNA strand elongation (GO:0022616)3.57918205
28folic acid-containing compound biosynthetic process (GO:0009396)3.52416374
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48861599
30mitotic chromosome condensation (GO:0007076)3.48511369
31histone arginine methylation (GO:0034969)3.37627676
32heterochromatin organization (GO:0070828)3.36037593
33viral mRNA export from host cell nucleus (GO:0046784)3.32481619
343-UTR-mediated mRNA stabilization (GO:0070935)3.28054169
35peptidyl-arginine N-methylation (GO:0035246)3.27120268
36peptidyl-arginine methylation (GO:0018216)3.27120268
37telomere maintenance via semi-conservative replication (GO:0032201)3.26396867
38establishment of integrated proviral latency (GO:0075713)3.25444640
39Golgi transport vesicle coating (GO:0048200)3.24769976
40COPI coating of Golgi vesicle (GO:0048205)3.24769976
41negative regulation of RNA splicing (GO:0033119)3.23339594
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.22575295
43protein targeting to membrane (GO:0006612)3.21551420
44pentose-phosphate shunt (GO:0006098)3.18437115
45nucleobase-containing small molecule interconversion (GO:0015949)3.17229604
46translation (GO:0006412)3.10849648
47mRNA catabolic process (GO:0006402)3.10403480
48negative regulation of mRNA processing (GO:0050686)3.09694534
49nuclear pore complex assembly (GO:0051292)3.08272134
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.06855486
51DNA replication initiation (GO:0006270)3.04372198
52regulation of translational termination (GO:0006449)3.04333840
53protein complex localization (GO:0031503)2.97914890
54RNA catabolic process (GO:0006401)2.97889332
55negative regulation of mRNA metabolic process (GO:1903312)2.93975658
56ribosome biogenesis (GO:0042254)2.91760819
57RNA stabilization (GO:0043489)2.87356405
58mRNA stabilization (GO:0048255)2.87356405
59protein-DNA complex disassembly (GO:0032986)2.83989146
60nucleosome disassembly (GO:0006337)2.83989146
61rRNA transcription (GO:0009303)2.81400559
62IMP biosynthetic process (GO:0006188)2.79627885
63NADPH regeneration (GO:0006740)2.78582587
64purine nucleobase biosynthetic process (GO:0009113)2.77075566
65nuclear envelope reassembly (GO:0031468)2.72817688
66mitotic nuclear envelope reassembly (GO:0007084)2.72817688
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70896541
68nucleobase biosynthetic process (GO:0046112)2.70745199
69negative regulation of erythrocyte differentiation (GO:0045647)2.67926033
70telomere maintenance via recombination (GO:0000722)2.65123391
71nuclear pore organization (GO:0006999)2.62685631
72rRNA processing (GO:0006364)2.61923033
73establishment of viral latency (GO:0019043)2.61293880
74L-serine metabolic process (GO:0006563)2.59645238
75folic acid metabolic process (GO:0046655)2.58428816
76mRNA splicing, via spliceosome (GO:0000398)2.58228820
77RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58228820
78protein localization to chromosome, centromeric region (GO:0071459)2.58096474
79GDP-mannose metabolic process (GO:0019673)2.57992857
80cellular protein complex localization (GO:0034629)2.57158498
81guanosine-containing compound biosynthetic process (GO:1901070)2.56678045
82glucose catabolic process (GO:0006007)2.56128570
83termination of RNA polymerase II transcription (GO:0006369)2.54526095
84ribosome assembly (GO:0042255)2.53825144
85maternal placenta development (GO:0001893)2.53099298
86IMP metabolic process (GO:0046040)2.52580332
87mitotic nuclear envelope disassembly (GO:0007077)2.52398040
88RNA splicing, via transesterification reactions (GO:0000375)2.52378121
89positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.52260276
90oxidative phosphorylation (GO:0006119)2.51953400
91pentose metabolic process (GO:0019321)2.47289297
92DNA topological change (GO:0006265)2.46232373
93rRNA metabolic process (GO:0016072)2.45196980
94cellular hyperosmotic response (GO:0071474)2.44828051
95regulation of chromatin binding (GO:0035561)2.43278075
96pinocytosis (GO:0006907)2.41833511
97regulation of mitochondrial translation (GO:0070129)2.41626079
98intracellular estrogen receptor signaling pathway (GO:0030520)2.41109424
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.40811770
100pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.40246435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12108686
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76687423
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.63072743
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05781386
5MYC_22102868_ChIP-Seq_BL_Human2.97702921
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63821335
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51471738
8VDR_21846776_ChIP-Seq_THP-1_Human2.35076706
9XRN2_22483619_ChIP-Seq_HELA_Human2.32329269
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29640329
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.21360759
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04071113
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.02776877
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98961409
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94192259
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93751875
17ZNF263_19887448_ChIP-Seq_K562_Human1.91775460
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89754610
19ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85680725
20THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82483874
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80019027
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71228016
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.70832207
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68649387
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67414457
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67244380
27DCP1A_22483619_ChIP-Seq_HELA_Human1.66551601
28TTF2_22483619_ChIP-Seq_HELA_Human1.63508708
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.63411036
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62363439
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61510069
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61096434
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60621081
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58651629
35LXR_22292898_ChIP-Seq_THP-1_Human1.56798666
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55730591
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55362051
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55181466
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53724774
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53573251
41RACK7_27058665_Chip-Seq_MCF-7_Human1.52153461
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.48028173
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47344461
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45034854
45CIITA_25753668_ChIP-Seq_RAJI_Human1.38035787
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37747980
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37395286
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37259986
49KDM5A_27292631_Chip-Seq_BREAST_Human1.36996053
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36649079
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.36338794
52GABP_19822575_ChIP-Seq_HepG2_Human1.36333274
53TCF7_22412390_ChIP-Seq_EML_Mouse1.31024409
54MAF_26560356_Chip-Seq_TH1_Human1.29742570
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28760170
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27981358
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27425620
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26876037
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.26875359
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24736881
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24177222
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.24084021
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23998147
64FOXP3_21729870_ChIP-Seq_TREG_Human1.23918645
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22921923
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22378135
67MAF_26560356_Chip-Seq_TH2_Human1.21860095
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21365055
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21358412
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21273800
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21098100
72KDM2B_26808549_Chip-Seq_DND41_Human1.20077132
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20028929
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19013580
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.18312716
76UTX_26944678_Chip-Seq_JUKART_Human1.14524922
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12978768
78NCOR1_26117541_ChIP-Seq_K562_Human1.11146564
79AR_21909140_ChIP-Seq_LNCAP_Human1.11061416
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10824505
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10266578
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09982158
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09055054
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08946760
85VDR_24763502_ChIP-Seq_THP-1_Human1.07527434
86P68_20966046_ChIP-Seq_HELA_Human1.06804535
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06059134
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05783114
89TFEB_21752829_ChIP-Seq_HELA_Human1.05583311
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05260133
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05249479
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05103436
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04086049
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02567039
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.02421397
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02139262
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01658695
98ATF3_27146783_Chip-Seq_COLON_Human1.01639733
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99694773
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.98765410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.32443574
2MP0003111_abnormal_nucleus_morphology3.22637963
3MP0004957_abnormal_blastocyst_morpholog3.10303448
4MP0005451_abnormal_body_composition2.93051158
5MP0003705_abnormal_hypodermis_morpholog2.85787402
6MP0010094_abnormal_chromosome_stability2.77182837
7MP0003077_abnormal_cell_cycle2.58690936
8MP0004185_abnormal_adipocyte_glucose2.39091319
9MP0002877_abnormal_melanocyte_morpholog2.35900890
10MP0009379_abnormal_foot_pigmentation2.28063435
11MP0002396_abnormal_hematopoietic_system2.06671979
12MP0010234_abnormal_vibrissa_follicle2.03829320
13MP0002796_impaired_skin_barrier2.02354754
14MP0009278_abnormal_bone_marrow1.99675821
15MP0000350_abnormal_cell_proliferation1.97542873
16MP0001730_embryonic_growth_arrest1.95295507
17MP0005076_abnormal_cell_differentiation1.95036965
18MP0008932_abnormal_embryonic_tissue1.93536265
19MP0009333_abnormal_splenocyte_physiolog1.93210578
20MP0000490_abnormal_crypts_of1.89561297
21MP0005501_abnormal_skin_physiology1.80497703
22MP0008057_abnormal_DNA_replication1.77194102
23MP0003763_abnormal_thymus_physiology1.74443634
24MP0001873_stomach_inflammation1.68261545
25MP0008007_abnormal_cellular_replicative1.63283823
26MP0000537_abnormal_urethra_morphology1.62166430
27MP0008058_abnormal_DNA_repair1.57489528
28MP0000313_abnormal_cell_death1.52490340
29MP0004808_abnormal_hematopoietic_stem1.52131545
30MP0009672_abnormal_birth_weight1.50213320
31MP0000678_abnormal_parathyroid_gland1.47275594
32MP0004264_abnormal_extraembryonic_tissu1.43386525
33MP0002080_prenatal_lethality1.41318082
34MP0002009_preneoplasia1.40388593
35MP0004858_abnormal_nervous_system1.39727119
36MP0001849_ear_inflammation1.38830770
37MP0000703_abnormal_thymus_morphology1.38316524
38MP0004233_abnormal_muscle_weight1.37835450
39MP0001346_abnormal_lacrimal_gland1.35919756
40MP0001672_abnormal_embryogenesis/_devel1.32532669
41MP0005380_embryogenesis_phenotype1.32532669
42MP0010352_gastrointestinal_tract_polyps1.30184624
43MP0000858_altered_metastatic_potential1.30176877
44MP0008260_abnormal_autophagy1.28860307
45MP0002019_abnormal_tumor_incidence1.25208945
46MP0002398_abnormal_bone_marrow1.25182312
47MP0010307_abnormal_tumor_latency1.25043592
48MP0003786_premature_aging1.24408154
49MP0005666_abnormal_adipose_tissue1.23681234
50MP0003984_embryonic_growth_retardation1.22356913
51MP0003453_abnormal_keratinocyte_physiol1.22349067
52MP0001697_abnormal_embryo_size1.21104703
53MP0001881_abnormal_mammary_gland1.20410521
54MP0005058_abnormal_lysosome_morphology1.15375176
55MP0002088_abnormal_embryonic_growth/wei1.15169116
56MP0002166_altered_tumor_susceptibility1.15070656
57MP0003315_abnormal_perineum_morphology1.13236823
58MP0002249_abnormal_larynx_morphology1.11514147
59MP0003806_abnormal_nucleotide_metabolis1.09666052
60MP0003941_abnormal_skin_development1.08752205
61MP0002085_abnormal_embryonic_tissue1.08215532
62MP0002722_abnormal_immune_system1.07563159
63MP0005623_abnormal_meninges_morphology1.05538992
64MP0003303_peritoneal_inflammation1.03885914
65MP0002086_abnormal_extraembryonic_tissu1.03372196
66MP0004947_skin_inflammation1.01418773
67MP0003436_decreased_susceptibility_to0.99924764
68MP0002429_abnormal_blood_cell0.98584960
69MP0001661_extended_life_span0.98356413
70MP0000733_abnormal_muscle_development0.97977543
71MP0006035_abnormal_mitochondrial_morpho0.97384382
72MP0001727_abnormal_embryo_implantation0.94312948
73MP0003566_abnormal_cell_adhesion0.93578195
74MP0004782_abnormal_surfactant_physiolog0.92940306
75MP0005621_abnormal_cell_physiology0.92340401
76MP0002254_reproductive_system_inflammat0.90243597
77MP0001348_abnormal_lacrimal_gland0.89249311
78MP0001835_abnormal_antigen_presentation0.89239660
79MP0005375_adipose_tissue_phenotype0.88953314
80MP0009053_abnormal_anal_canal0.88689604
81MP0000358_abnormal_cell_content/0.88373607
82MP0009931_abnormal_skin_appearance0.87625445
83MP0000477_abnormal_intestine_morphology0.87485527
84MP0002006_tumorigenesis0.86070776
85MP0000689_abnormal_spleen_morphology0.85639484
86MP0002060_abnormal_skin_morphology0.85015163
87MP0001216_abnormal_epidermal_layer0.84829785
88MP0004197_abnormal_fetal_growth/weight/0.83695589
89MP0005384_cellular_phenotype0.83037690
90MP0000627_abnormal_mammary_gland0.82771765
91MP0002163_abnormal_gland_morphology0.82565132
92MP0000716_abnormal_immune_system0.81383108
93MP0002098_abnormal_vibrissa_morphology0.80780501
94MP0010030_abnormal_orbit_morphology0.80500187
95MP0005397_hematopoietic_system_phenotyp0.79881841
96MP0001545_abnormal_hematopoietic_system0.79881841
97MP0005000_abnormal_immune_tolerance0.79482408
98MP0002084_abnormal_developmental_patter0.79036618
99MP0002089_abnormal_postnatal_growth/wei0.76513814
100MP0001853_heart_inflammation0.75146655

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.87355363
2Abnormality of cells of the erythroid lineage (HP:0012130)3.78880837
3Progressive muscle weakness (HP:0003323)3.70183646
4Abnormal number of erythroid precursors (HP:0012131)3.36473768
5Microvesicular hepatic steatosis (HP:0001414)3.33491841
6Multiple enchondromatosis (HP:0005701)3.09117823
7Macrocytic anemia (HP:0001972)3.03576837
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03350003
9Trismus (HP:0000211)2.97815906
10Selective tooth agenesis (HP:0001592)2.92913027
11Hyperacusis (HP:0010780)2.87399442
12Aplastic anemia (HP:0001915)2.79288871
13Pallor (HP:0000980)2.72396329
14Septate vagina (HP:0001153)2.71087954
15Abnormality of the umbilical cord (HP:0010881)2.62031870
16Ragged-red muscle fibers (HP:0003200)2.60751789
17Centrally nucleated skeletal muscle fibers (HP:0003687)2.57002531
18Broad distal phalanx of finger (HP:0009836)2.47388596
19Abnormal gallbladder physiology (HP:0012438)2.46836257
20Cholecystitis (HP:0001082)2.46836257
21Asymmetry of the thorax (HP:0001555)2.44207196
22Abnormality of the fetal cardiovascular system (HP:0010948)2.43077350
23Abnormal umbilical cord blood vessels (HP:0011403)2.43077350
24Single umbilical artery (HP:0001195)2.43077350
25Progressive external ophthalmoplegia (HP:0000590)2.42709037
26Abnormality of reticulocytes (HP:0004312)2.42500257
27Long palpebral fissure (HP:0000637)2.26820141
28Achilles tendon contracture (HP:0001771)2.19731388
29Vertebral compression fractures (HP:0002953)2.16668634
30Myopathic facies (HP:0002058)2.16385476
31Testicular atrophy (HP:0000029)2.15846236
32Rough bone trabeculation (HP:0100670)2.10892823
33Hypertensive crisis (HP:0100735)2.06513119
34Thrombocytosis (HP:0001894)2.06465326
35Seborrheic dermatitis (HP:0001051)2.06102015
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06090033
37Colitis (HP:0002583)2.01337829
38Agammaglobulinemia (HP:0004432)1.97727327
39Premature skin wrinkling (HP:0100678)1.93290656
40Fatigue (HP:0012378)1.90186656
41Insomnia (HP:0100785)1.89683567
42Cellulitis (HP:0100658)1.89001590
43Gastrointestinal inflammation (HP:0004386)1.88951004
44Recurrent viral infections (HP:0004429)1.88752640
45Disproportionate tall stature (HP:0001519)1.88510004
46Microretrognathia (HP:0000308)1.83939413
47Gastrointestinal stroma tumor (HP:0100723)1.83281852
48Biconcave vertebral bodies (HP:0004586)1.83134096
49Chromsome breakage (HP:0040012)1.82456119
50Abnormality of the thoracic spine (HP:0100711)1.82176961
51Abnormality of the Achilles tendon (HP:0005109)1.80324269
52Abnormalities of placenta or umbilical cord (HP:0001194)1.80157488
53IgM deficiency (HP:0002850)1.80147622
54Breast hypoplasia (HP:0003187)1.80066998
55Proximal placement of thumb (HP:0009623)1.77256308
56Syringomyelia (HP:0003396)1.75880238
57Spinal cord lesions (HP:0100561)1.75880238
58Deep palmar crease (HP:0006191)1.75467121
59Abnormality of the distal phalanges of the toes (HP:0010182)1.75226260
60Calcaneovalgus deformity (HP:0001848)1.74990684
61Dysmetric saccades (HP:0000641)1.74145423
62Reticulocytosis (HP:0001923)1.73884681
63Deviation of the thumb (HP:0009603)1.71366283
64Birth length less than 3rd percentile (HP:0003561)1.71134955
65Impaired proprioception (HP:0010831)1.69758772
66Distal lower limb amyotrophy (HP:0008944)1.69382603
67Squamous cell carcinoma (HP:0002860)1.66350200
68Abnormal trabecular bone morphology (HP:0100671)1.65636377
69Abnormality of the calcaneus (HP:0008364)1.65270089
70Atresia of the external auditory canal (HP:0000413)1.65153856
71Generalized amyotrophy (HP:0003700)1.64348371
72Sparse lateral eyebrow (HP:0005338)1.63614542
73Aplasia/Hypoplasia of the thymus (HP:0010515)1.63194149
74Unilateral renal agenesis (HP:0000122)1.61569184
75Abnormality of the fingertips (HP:0001211)1.57986629
76Abnormality of the phalanges of the hallux (HP:0010057)1.57877120
77Micronodular cirrhosis (HP:0001413)1.57531553
78Protrusio acetabuli (HP:0003179)1.57385893
79Segmental peripheral demyelination/remyelination (HP:0003481)1.57345860
80Patellar dislocation (HP:0002999)1.55824500
81Ulnar bowing (HP:0003031)1.55121905
82Short middle phalanx of the 5th finger (HP:0004220)1.54700229
83Orthostatic hypotension (HP:0001278)1.54352334
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.53583280
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.53583280
86Pancytopenia (HP:0001876)1.53304448
87Acute lymphatic leukemia (HP:0006721)1.52978939
88Truncus arteriosus (HP:0001660)1.52868494
89Glossoptosis (HP:0000162)1.52042708
90Thin bony cortex (HP:0002753)1.51419232
91Premature ovarian failure (HP:0008209)1.51097273
92Gout (HP:0001997)1.51015626
93Thoracic kyphosis (HP:0002942)1.51005744
94Nasolacrimal duct obstruction (HP:0000579)1.50624488
95Fasciculations (HP:0002380)1.49542490
96Breech presentation (HP:0001623)1.48959437
97Distal lower limb muscle weakness (HP:0009053)1.48683853
98Nonimmune hydrops fetalis (HP:0001790)1.48168178
99Viral hepatitis (HP:0006562)1.48004210
100Abnormality of small intestinal villus morphology (HP:0011472)1.47834082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.79354443
2NME23.91424650
3EEF2K3.84220191
4SMG13.68874083
5PRPF4B2.93696537
6VRK22.73196559
7MAP3K102.52515111
8IRAK32.36646788
9SCYL22.33558268
10CDK122.09246824
11BUB11.95630477
12RPS6KB21.92214302
13TESK21.85629763
14CDC71.81702793
15PKN21.80463721
16TAOK21.79511207
17SIK11.78536396
18MAP4K11.60898739
19ICK1.53840046
20PASK1.52808953
21KDR1.42886604
22ARAF1.37256808
23PBK1.31274391
24PAK41.30484758
25CDK71.26721158
26CDK41.26534063
27ERN11.25890745
28SRPK11.23736773
29TTK1.18164658
30ILK1.15625668
31LRRK21.14731447
32MAP3K131.11137241
33EIF2AK11.08339404
34MAP2K31.04082171
35MAP3K81.02259519
36BRAF0.97618666
37FGFR40.95540034
38EPHA20.95129077
39CDK190.94363997
40CHEK20.92653599
41MAP2K20.91558282
42NME10.87999944
43PIM20.85739125
44MAP3K140.85046387
45MAP3K110.83007093
46CDK80.81246134
47IRAK40.80897891
48PTK60.78926617
49IRAK20.77337415
50ATR0.75336049
51CDK60.75142498
52TAF10.74880973
53MTOR0.74384815
54RPS6KA40.71081064
55TBK10.70300177
56TESK10.69892360
57GRK60.69461381
58KSR20.64891057
59CHEK10.64674791
60AURKA0.63288697
61RPS6KC10.61735976
62RPS6KL10.61735976
63STK40.60565297
64ALK0.60060261
65AURKB0.60024755
66CLK10.59599707
67NEK10.59077570
68MAPK110.56687640
69STK160.56297621
70AKT20.55641100
71MAP3K10.54470234
72NEK20.53836686
73TAOK10.51987532
74BRD40.48231599
75MAPKAPK30.48198352
76LATS20.48009483
77DYRK30.47474822
78PIM10.46490011
79CDK20.45551083
80BCKDK0.44768643
81RIPK40.44410092
82PDGFRA0.44257579
83PDPK10.44077178
84CDK90.43502304
85SIK30.43354671
86JAK30.43352368
87TTN0.42322653
88DAPK10.42147820
89RPS6KA10.41802094
90MAP3K90.40937535
91RPS6KA60.39960182
92IKBKB0.39117939
93PAK10.39067853
94PRKD30.38801894
95BTK0.37630116
96PRKCI0.35819071
97MAP3K30.35299132
98VRK10.32344195
99RPS6KA20.32165676
100PRKD20.32022897

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54786918
2DNA replication_Homo sapiens_hsa030304.04171210
3Spliceosome_Homo sapiens_hsa030402.87654961
4Base excision repair_Homo sapiens_hsa034102.78908589
5Mismatch repair_Homo sapiens_hsa034302.44900790
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32648391
7Pentose phosphate pathway_Homo sapiens_hsa000302.15312520
8Biosynthesis of amino acids_Homo sapiens_hsa012302.01889240
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98206782
10RNA transport_Homo sapiens_hsa030131.93998245
11One carbon pool by folate_Homo sapiens_hsa006701.89761937
12Pyrimidine metabolism_Homo sapiens_hsa002401.71649254
13Cell cycle_Homo sapiens_hsa041101.71544082
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70797679
15Nucleotide excision repair_Homo sapiens_hsa034201.70458529
16Acute myeloid leukemia_Homo sapiens_hsa052211.68077991
17Proteasome_Homo sapiens_hsa030501.62948860
18Thyroid cancer_Homo sapiens_hsa052161.62151984
19Chronic myeloid leukemia_Homo sapiens_hsa052201.55992404
20RNA polymerase_Homo sapiens_hsa030201.50363808
21mRNA surveillance pathway_Homo sapiens_hsa030151.49789640
22Bladder cancer_Homo sapiens_hsa052191.48681422
23Sulfur relay system_Homo sapiens_hsa041221.43521735
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.42487976
25Carbon metabolism_Homo sapiens_hsa012001.40889161
26Fructose and mannose metabolism_Homo sapiens_hsa000511.39720551
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37738729
28Non-small cell lung cancer_Homo sapiens_hsa052231.35523655
29B cell receptor signaling pathway_Homo sapiens_hsa046621.31090753
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21237793
31Primary immunodeficiency_Homo sapiens_hsa053401.17157995
32Homologous recombination_Homo sapiens_hsa034401.11503075
33Pancreatic cancer_Homo sapiens_hsa052121.09906612
34Non-homologous end-joining_Homo sapiens_hsa034501.09060394
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08928303
36Herpes simplex infection_Homo sapiens_hsa051681.08322361
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.05665069
38HTLV-I infection_Homo sapiens_hsa051661.04611595
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03952630
40Other glycan degradation_Homo sapiens_hsa005110.97278402
41Galactose metabolism_Homo sapiens_hsa000520.97063065
42Viral carcinogenesis_Homo sapiens_hsa052030.95976541
43VEGF signaling pathway_Homo sapiens_hsa043700.84877826
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.84482926
45Shigellosis_Homo sapiens_hsa051310.83902011
46Endometrial cancer_Homo sapiens_hsa052130.83643627
47Apoptosis_Homo sapiens_hsa042100.83188602
48Small cell lung cancer_Homo sapiens_hsa052220.82010325
49Purine metabolism_Homo sapiens_hsa002300.81051531
50Hepatitis B_Homo sapiens_hsa051610.79588772
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79282872
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78468277
53Notch signaling pathway_Homo sapiens_hsa043300.74934679
54Prostate cancer_Homo sapiens_hsa052150.73660067
55Colorectal cancer_Homo sapiens_hsa052100.73013696
56mTOR signaling pathway_Homo sapiens_hsa041500.72876617
57Viral myocarditis_Homo sapiens_hsa054160.71021447
58p53 signaling pathway_Homo sapiens_hsa041150.70827654
59N-Glycan biosynthesis_Homo sapiens_hsa005100.70610933
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69811585
61T cell receptor signaling pathway_Homo sapiens_hsa046600.67890520
62RNA degradation_Homo sapiens_hsa030180.65379596
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65105088
64Antigen processing and presentation_Homo sapiens_hsa046120.64705241
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.64031940
66Influenza A_Homo sapiens_hsa051640.63037717
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62549850
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60475178
69Folate biosynthesis_Homo sapiens_hsa007900.59999285
70Measles_Homo sapiens_hsa051620.59197495
71MicroRNAs in cancer_Homo sapiens_hsa052060.57915231
72Insulin signaling pathway_Homo sapiens_hsa049100.57673280
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56872037
74Renal cell carcinoma_Homo sapiens_hsa052110.56180859
75Leishmaniasis_Homo sapiens_hsa051400.55582263
76Allograft rejection_Homo sapiens_hsa053300.54895315
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54267278
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53989967
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52129074
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50964157
81Glioma_Homo sapiens_hsa052140.50662194
82HIF-1 signaling pathway_Homo sapiens_hsa040660.48056893
83Fanconi anemia pathway_Homo sapiens_hsa034600.47902115
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47673508
85Autoimmune thyroid disease_Homo sapiens_hsa053200.47377579
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47010313
87Prion diseases_Homo sapiens_hsa050200.46307559
88Pyruvate metabolism_Homo sapiens_hsa006200.46162042
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.46092138
90ErbB signaling pathway_Homo sapiens_hsa040120.43729926
91Parkinsons disease_Homo sapiens_hsa050120.43223736
92Huntingtons disease_Homo sapiens_hsa050160.42778826
93Asthma_Homo sapiens_hsa053100.42146902
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41788605
95Hepatitis C_Homo sapiens_hsa051600.41691922
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41439292
97AMPK signaling pathway_Homo sapiens_hsa041520.40386719
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39990008
99Glutathione metabolism_Homo sapiens_hsa004800.39099168
100Toxoplasmosis_Homo sapiens_hsa051450.38014425

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