RPS2P52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.13377986
2ribosomal small subunit assembly (GO:0000028)6.04935158
3maturation of SSU-rRNA (GO:0030490)5.97848160
4translational termination (GO:0006415)5.85037086
5ribosomal small subunit biogenesis (GO:0042274)5.20421515
6DNA deamination (GO:0045006)5.01580094
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.00938499
8cotranslational protein targeting to membrane (GO:0006613)4.96614217
9protein targeting to ER (GO:0045047)4.94509392
10translational elongation (GO:0006414)4.89421378
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.69552113
12protein localization to endoplasmic reticulum (GO:0070972)4.69249753
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.67521598
14ATP synthesis coupled proton transport (GO:0015986)4.67521598
15behavioral response to nicotine (GO:0035095)4.60712925
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.58534669
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.51471600
18protein complex biogenesis (GO:0070271)4.47757322
19cellular ketone body metabolic process (GO:0046950)4.44558584
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.38253402
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.36438174
22viral life cycle (GO:0019058)4.34529343
23cellular protein complex disassembly (GO:0043624)4.33355236
24cell wall macromolecule catabolic process (GO:0016998)4.29601847
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29237059
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.29237059
27NADH dehydrogenase complex assembly (GO:0010257)4.29237059
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11940143
29mitochondrial respiratory chain complex assembly (GO:0033108)4.04325767
30ketone body metabolic process (GO:1902224)3.90028119
31translational initiation (GO:0006413)3.89346782
32protein complex disassembly (GO:0043241)3.75466471
33GTP biosynthetic process (GO:0006183)3.67053789
34chaperone-mediated protein transport (GO:0072321)3.64934395
35adaptation of signaling pathway (GO:0023058)3.64829164
36positive regulation of prostaglandin secretion (GO:0032308)3.60910170
37somite development (GO:0061053)3.59965115
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58620763
39regulation of mitochondrial translation (GO:0070129)3.53948307
40macromolecular complex disassembly (GO:0032984)3.51474028
41cell wall macromolecule metabolic process (GO:0044036)3.51213905
42pseudouridine synthesis (GO:0001522)3.50814899
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.42072521
44termination of RNA polymerase III transcription (GO:0006386)3.42072521
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.40480994
46translation (GO:0006412)3.37924977
47cytochrome complex assembly (GO:0017004)3.29563037
48UTP biosynthetic process (GO:0006228)3.27455705
49mRNA catabolic process (GO:0006402)3.27188777
50cellular component biogenesis (GO:0044085)3.23365701
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.22521501
52UTP metabolic process (GO:0046051)3.21770561
53rRNA processing (GO:0006364)3.19674036
54fucose catabolic process (GO:0019317)3.17266538
55L-fucose metabolic process (GO:0042354)3.17266538
56L-fucose catabolic process (GO:0042355)3.17266538
57inner mitochondrial membrane organization (GO:0007007)3.16465024
58water-soluble vitamin biosynthetic process (GO:0042364)3.14684916
59male meiosis I (GO:0007141)3.13854159
60rRNA metabolic process (GO:0016072)3.12807445
61protein neddylation (GO:0045116)3.12004107
62respiratory chain complex IV assembly (GO:0008535)3.11142153
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11025799
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10623219
65protein targeting to membrane (GO:0006612)3.10381796
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09937117
67spliceosomal complex assembly (GO:0000245)3.05672396
68ribosomal large subunit biogenesis (GO:0042273)3.05198091
69negative regulation of DNA-templated transcription, elongation (GO:0032785)3.02281247
70RNA catabolic process (GO:0006401)3.01701300
71ribonucleoprotein complex biogenesis (GO:0022613)3.01294980
72protein polyglutamylation (GO:0018095)2.97996396
73electron transport chain (GO:0022900)2.96351002
74respiratory electron transport chain (GO:0022904)2.94749384
75ATP biosynthetic process (GO:0006754)2.92803039
76phosphatidylserine acyl-chain remodeling (GO:0036150)2.88553568
77rRNA modification (GO:0000154)2.85822351
78DNA replication checkpoint (GO:0000076)2.83305585
79regulation of prostaglandin secretion (GO:0032306)2.81351655
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80894232
81positive regulation of fatty acid transport (GO:2000193)2.80889060
82guanosine-containing compound biosynthetic process (GO:1901070)2.78560505
83preassembly of GPI anchor in ER membrane (GO:0016254)2.75826204
84replication fork processing (GO:0031297)2.72986848
85protein-cofactor linkage (GO:0018065)2.71323943
86hydrogen ion transmembrane transport (GO:1902600)2.70847095
87leukotriene biosynthetic process (GO:0019370)2.68598384
88negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.67274600
89head development (GO:0060322)2.66791755
90positive regulation of icosanoid secretion (GO:0032305)2.66033735
91protein homotrimerization (GO:0070207)2.64742505
92ribonucleoside triphosphate biosynthetic process (GO:0009201)2.64299887
93regulation of cilium movement (GO:0003352)2.64030049
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63013666
95negative regulation of multicellular organism growth (GO:0040015)2.62862739
96regulation of catecholamine metabolic process (GO:0042069)2.62582974
97regulation of dopamine metabolic process (GO:0042053)2.62582974
98purine-containing compound salvage (GO:0043101)2.57875588
99urate metabolic process (GO:0046415)2.54854863
100phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54477511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.65666014
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03691210
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.02685932
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91582203
5ETS1_20019798_ChIP-Seq_JURKAT_Human2.76797970
6ZNF274_21170338_ChIP-Seq_K562_Hela2.75984002
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74437543
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.72773109
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58406478
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.55906570
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48373764
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43145268
13VDR_22108803_ChIP-Seq_LS180_Human2.40330376
14VDR_23849224_ChIP-Seq_CD4+_Human2.37611496
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35547561
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34270560
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.29593746
18FOXP3_21729870_ChIP-Seq_TREG_Human2.22680190
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.07677772
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02948756
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98394680
22IRF1_19129219_ChIP-ChIP_H3396_Human1.93297627
23CIITA_25753668_ChIP-Seq_RAJI_Human1.92075024
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84060452
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.82098102
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77631489
27XRN2_22483619_ChIP-Seq_HELA_Human1.69194712
28ELK1_19687146_ChIP-ChIP_HELA_Human1.69033107
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67255108
30TP53_22573176_ChIP-Seq_HFKS_Human1.66908676
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61681365
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59729064
33GABP_19822575_ChIP-Seq_HepG2_Human1.56985974
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56035387
35TTF2_22483619_ChIP-Seq_HELA_Human1.53964542
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53014419
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52609389
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51313978
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.50583602
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50055549
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.49699137
42MYC_18940864_ChIP-ChIP_HL60_Human1.48545764
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44270589
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42344310
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42093264
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40926941
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36430920
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34724028
49P300_27268052_Chip-Seq_Bcells_Human1.33614317
50SPI1_20517297_ChIP-Seq_HL60_Human1.32972894
51NCOR_22424771_ChIP-Seq_293T_Human1.32762800
52AR_20517297_ChIP-Seq_VCAP_Human1.32727460
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30860334
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28335522
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.28221953
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28178032
57NANOG_20526341_ChIP-Seq_ESCs_Human1.27945895
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27689033
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27646806
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27483575
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27161846
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25807667
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25799764
64E2F1_20622854_ChIP-Seq_HELA_Human1.24244825
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.23413812
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22426253
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.22426253
68RAC3_21632823_ChIP-Seq_H3396_Human1.21219865
69TAF2_19829295_ChIP-Seq_ESCs_Human1.20368508
70DCP1A_22483619_ChIP-Seq_HELA_Human1.19855664
71P53_21459846_ChIP-Seq_SAOS-2_Human1.19142872
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15544257
73ERA_21632823_ChIP-Seq_H3396_Human1.15110913
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14791391
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11312622
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08516562
77OCT4_20526341_ChIP-Seq_ESCs_Human1.07613370
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06073269
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04688825
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04115730
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04090832
82PHF8_20622854_ChIP-Seq_HELA_Human1.03433071
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01086235
84BCL6_27268052_Chip-Seq_Bcells_Human1.00758454
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00481576
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00374023
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98398761
88STAT1_20625510_ChIP-Seq_HELA_Human0.98345900
89BCOR_27268052_Chip-Seq_Bcells_Human0.98166036
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97977042
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97956153
92EWS_26573619_Chip-Seq_HEK293_Human0.97767104
93P68_20966046_ChIP-Seq_HELA_Human0.95813432
94FOXP1_21924763_ChIP-Seq_HESCs_Human0.95638696
95CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94390643
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92209106
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.91674206
98IGF1R_20145208_ChIP-Seq_DFB_Human0.90724918
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90207347
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89146209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.96562190
2MP0009379_abnormal_foot_pigmentation4.01520335
3MP0001986_abnormal_taste_sensitivity3.38972445
4MP0004147_increased_porphyrin_level2.94646389
5MP0001968_abnormal_touch/_nociception2.55489838
6MP0002736_abnormal_nociception_after2.52009656
7MP0008789_abnormal_olfactory_epithelium2.23270089
8MP0001485_abnormal_pinna_reflex2.20875586
9MP0008875_abnormal_xenobiotic_pharmacok2.09671873
10MP0000372_irregular_coat_pigmentation2.05272715
11MP0002234_abnormal_pharynx_morphology2.01296559
12MP0008877_abnormal_DNA_methylation1.93369784
13MP0004142_abnormal_muscle_tone1.92786473
14MP0008058_abnormal_DNA_repair1.88827406
15MP0002102_abnormal_ear_morphology1.88020051
16MP0005551_abnormal_eye_electrophysiolog1.85443869
17MP0004885_abnormal_endolymph1.84207656
18MP0008872_abnormal_physiological_respon1.76976144
19MP0002876_abnormal_thyroid_physiology1.76924232
20MP0002163_abnormal_gland_morphology1.74509961
21MP0002396_abnormal_hematopoietic_system1.70793393
22MP0000569_abnormal_digit_pigmentation1.69620242
23MP0001293_anophthalmia1.66044681
24MP0005075_abnormal_melanosome_morpholog1.65161857
25MP0004145_abnormal_muscle_electrophysio1.62864865
26MP0003283_abnormal_digestive_organ1.59841878
27MP0003787_abnormal_imprinting1.57609255
28MP0005084_abnormal_gallbladder_morpholo1.53549871
29MP0005174_abnormal_tail_pigmentation1.52389150
30MP0005394_taste/olfaction_phenotype1.50208705
31MP0005499_abnormal_olfactory_system1.50208705
32MP0006276_abnormal_autonomic_nervous1.45989686
33MP0005360_urolithiasis1.42343264
34MP0002938_white_spotting1.39980089
35MP0003122_maternal_imprinting1.38269422
36MP0001905_abnormal_dopamine_level1.36921103
37MP0002837_dystrophic_cardiac_calcinosis1.34499190
38MP0002160_abnormal_reproductive_system1.32239754
39MP0005646_abnormal_pituitary_gland1.31857660
40MP0005671_abnormal_response_to1.29841367
41MP0005647_abnormal_sex_gland1.27709363
42MP0003195_calcinosis1.24687945
43MP0005410_abnormal_fertilization1.18014623
44MP0004742_abnormal_vestibular_system1.17531869
45MP0006036_abnormal_mitochondrial_physio1.17404915
46MP0006072_abnormal_retinal_apoptosis1.13305050
47MP0005389_reproductive_system_phenotype1.12551550
48MP0002095_abnormal_skin_pigmentation1.10997135
49MP0009745_abnormal_behavioral_response1.08798021
50MP0002909_abnormal_adrenal_gland1.08091132
51MP0003718_maternal_effect1.04702481
52MP0005310_abnormal_salivary_gland1.04402467
53MP0002277_abnormal_respiratory_mucosa1.02644209
54MP0005332_abnormal_amino_acid1.00273457
55MP0005195_abnormal_posterior_eye0.98409680
56MP0003938_abnormal_ear_development0.98180671
57MP0001984_abnormal_olfaction0.97767977
58MP0002733_abnormal_thermal_nociception0.97571334
59MP0000613_abnormal_salivary_gland0.96541808
60MP0008995_early_reproductive_senescence0.95838675
61MP0003786_premature_aging0.94806593
62MP0001970_abnormal_pain_threshold0.93632117
63MP0002272_abnormal_nervous_system0.92101256
64MP0002210_abnormal_sex_determination0.91938707
65MP0001919_abnormal_reproductive_system0.91887328
66MP0003646_muscle_fatigue0.91549168
67MP0000631_abnormal_neuroendocrine_gland0.91093750
68MP0001756_abnormal_urination0.90830330
69MP0002693_abnormal_pancreas_physiology0.89813567
70MP0001929_abnormal_gametogenesis0.88609151
71MP0002090_abnormal_vision0.87453159
72MP0010329_abnormal_lipoprotein_level0.86607379
73MP0010094_abnormal_chromosome_stability0.82567432
74MP0005645_abnormal_hypothalamus_physiol0.79825776
75MP0001835_abnormal_antigen_presentation0.79728283
76MP0006035_abnormal_mitochondrial_morpho0.79365816
77MP0002638_abnormal_pupillary_reflex0.79360073
78MP0005379_endocrine/exocrine_gland_phen0.78932529
79MP0000653_abnormal_sex_gland0.77098500
80MP0003119_abnormal_digestive_system0.76259178
81MP0003121_genomic_imprinting0.75653862
82MP0004133_heterotaxia0.75627788
83MP0000230_abnormal_systemic_arterial0.75374588
84MP0005636_abnormal_mineral_homeostasis0.74753534
85MP0003698_abnormal_male_reproductive0.74443512
86MP0002067_abnormal_sensory_capabilities0.74103182
87MP0001529_abnormal_vocalization0.73181212
88MP0001944_abnormal_pancreas_morphology0.72103109
89MP0009643_abnormal_urine_homeostasis0.71931045
90MP0001963_abnormal_hearing_physiology0.71900109
91MP0002752_abnormal_somatic_nervous0.71256351
92MP0001145_abnormal_male_reproductive0.71081072
93MP0003806_abnormal_nucleotide_metabolis0.70747030
94MP0001764_abnormal_homeostasis0.69832980
95MP0005220_abnormal_exocrine_pancreas0.69510648
96MP0002734_abnormal_mechanical_nocicepti0.67788077
97MP0004381_abnormal_hair_follicle0.67584777
98MP0003183_abnormal_peptide_metabolism0.67182447
99MP0002184_abnormal_innervation0.66600119
100MP0001502_abnormal_circadian_rhythm0.66207954

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.23183760
2Visual hallucinations (HP:0002367)4.19663292
3Abnormality of cells of the erythroid lineage (HP:0012130)4.19647446
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.02869482
5Abnormal number of erythroid precursors (HP:0012131)3.95523371
6Duplicated collecting system (HP:0000081)3.93390221
7Abnormality of the renal collecting system (HP:0004742)3.76062185
8Abnormality of midbrain morphology (HP:0002418)3.67113893
9Molar tooth sign on MRI (HP:0002419)3.67113893
10Abnormal rod and cone electroretinograms (HP:0008323)3.56328348
11Acute lymphatic leukemia (HP:0006721)3.49835213
12Mitochondrial inheritance (HP:0001427)3.42727584
13Acute necrotizing encephalopathy (HP:0006965)3.37929502
14Pancreatic fibrosis (HP:0100732)3.36207863
15Pancreatic cysts (HP:0001737)3.35038818
16Acute encephalopathy (HP:0006846)3.30685457
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16513640
18Hepatocellular necrosis (HP:0001404)3.08885203
19Abnormal mitochondria in muscle tissue (HP:0008316)3.08106976
203-Methylglutaconic aciduria (HP:0003535)3.05624089
21Increased CSF lactate (HP:0002490)3.05372243
22Congenital stationary night blindness (HP:0007642)3.04327887
23Pendular nystagmus (HP:0012043)2.82060773
24Macrocytic anemia (HP:0001972)2.76984012
25Progressive macrocephaly (HP:0004481)2.75809359
26Chromsome breakage (HP:0040012)2.72431640
27Absent thumb (HP:0009777)2.67045525
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64641795
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.59360592
30True hermaphroditism (HP:0010459)2.57871270
31Pallor (HP:0000980)2.57279368
32Cerebral edema (HP:0002181)2.54177850
33Hepatic necrosis (HP:0002605)2.52367094
34Optic disc pallor (HP:0000543)2.47930494
35Bilateral microphthalmos (HP:0007633)2.46368403
36Lipid accumulation in hepatocytes (HP:0006561)2.44400837
37Prostate neoplasm (HP:0100787)2.41678404
38Increased hepatocellular lipid droplets (HP:0006565)2.39076703
39Abnormality of the renal cortex (HP:0011035)2.38726887
40Elevated erythrocyte sedimentation rate (HP:0003565)2.32672305
41Abnormality of the prostate (HP:0008775)2.32006230
42Cystic liver disease (HP:0006706)2.25058337
43Clubbing of toes (HP:0100760)2.23590557
44Abnormality of T cell physiology (HP:0011840)2.19755352
45Testicular atrophy (HP:0000029)2.16961537
46Autoimmune thrombocytopenia (HP:0001973)2.13203202
47Abnormality of the labia minora (HP:0012880)2.12472602
48Abolished electroretinogram (ERG) (HP:0000550)2.09803491
49Septo-optic dysplasia (HP:0100842)2.08568186
50Anophthalmia (HP:0000528)2.06028461
51Lactic acidosis (HP:0003128)2.05879069
52Triphalangeal thumb (HP:0001199)2.02843015
53Abnormality of DNA repair (HP:0003254)2.02321724
54Duplication of thumb phalanx (HP:0009942)2.02290491
55Hyperglycinemia (HP:0002154)2.00699238
56Microretrognathia (HP:0000308)1.98650724
57Postaxial foot polydactyly (HP:0001830)1.98568860
58Horseshoe kidney (HP:0000085)1.98551391
59Respiratory failure (HP:0002878)1.97836353
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96981065
61Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96981065
62Oligodactyly (hands) (HP:0001180)1.96262195
63Renal cortical cysts (HP:0000803)1.95281381
64Neutropenia (HP:0001875)1.93813845
65Aplasia/Hypoplasia of the spleen (HP:0010451)1.93175571
66Sclerocornea (HP:0000647)1.93167914
67Abnormal respiratory epithelium morphology (HP:0012253)1.92856269
68Abnormal respiratory motile cilium morphology (HP:0005938)1.92856269
69Renal Fanconi syndrome (HP:0001994)1.89763180
70Thrombocytosis (HP:0001894)1.88762100
71Meckel diverticulum (HP:0002245)1.88692472
72Abnormality of the ileum (HP:0001549)1.87349514
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85462222
74Increased serum lactate (HP:0002151)1.84633861
75Abnormal number of incisors (HP:0011064)1.84419423
76Hypoplasia of the radius (HP:0002984)1.83551097
77Lethargy (HP:0001254)1.82463882
78Asplenia (HP:0001746)1.82115530
79Ureteral duplication (HP:0000073)1.81374369
80Ectopic kidney (HP:0000086)1.81233386
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80446562
82Constricted visual fields (HP:0001133)1.79480027
83Nephronophthisis (HP:0000090)1.79233728
84Parakeratosis (HP:0001036)1.78638786
85Abnormal drinking behavior (HP:0030082)1.78004401
86Polydipsia (HP:0001959)1.78004401
87Pigmentary retinal degeneration (HP:0001146)1.77169135
88Cleft eyelid (HP:0000625)1.75660076
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.74492703
90Rib fusion (HP:0000902)1.73769829
91Depressed nasal ridge (HP:0000457)1.72996893
92Type II lissencephaly (HP:0007260)1.72242652
93Focal motor seizures (HP:0011153)1.71757546
94Tubulointerstitial nephritis (HP:0001970)1.71659998
95Increased cerebral lipofuscin (HP:0011813)1.70983734
96Poor head control (HP:0002421)1.70805573
97Attenuation of retinal blood vessels (HP:0007843)1.70682677
98Chronic hepatic failure (HP:0100626)1.67254987
99Dyschromatopsia (HP:0007641)1.66738606
100Short thumb (HP:0009778)1.66173451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.34329796
2TLK14.54660466
3MAP4K23.95039562
4FRK3.51749342
5WNK32.87562395
6SIK22.55366518
7GRK72.49287802
8ADRBK22.23042448
9NEK22.12456564
10ZAK2.06862053
11VRK22.03127636
12NUAK11.99373185
13GRK51.74772264
14EIF2AK11.73088726
15PLK41.70774860
16MOS1.66182600
17MAP3K111.53773103
18OXSR11.48556940
19BCKDK1.40223316
20MAP3K41.39366986
21MATK1.39221851
22KIT1.37131460
23MAP4K11.35458932
24BUB11.33668295
25ACVR1B1.33263128
26MUSK1.31050071
27GRK11.30826703
28BMPR1B1.28651009
29FES1.26234438
30MKNK21.22662727
31LRRK21.21350495
32PIK3CG1.15648271
33NME11.14287087
34WNK41.13227032
35TAOK31.10043767
36ADRBK11.09530824
37STK161.08248202
38IRAK41.08135198
39CDC71.07390552
40STK41.03279535
41NME21.00453517
42STK390.99165065
43VRK10.97036471
44BMPR20.93450077
45CDK190.92830398
46DYRK20.91190434
47ITK0.87648745
48STK100.86953194
49GRK60.86163797
50EIF2AK20.82891922
51DAPK20.82853992
52AURKA0.80248016
53MKNK10.79226757
54TGFBR20.78576452
55MAPK130.76034585
56FLT30.69588811
57NEK10.68981722
58IKBKB0.63515887
59AURKB0.61457253
60LYN0.58947873
61PINK10.58765722
62BTK0.58075866
63WEE10.57842264
64TEC0.57690652
65DAPK10.57133439
66PRKCQ0.57030382
67PRKD30.56621760
68INSRR0.53900647
69KDR0.51134588
70STK30.51116389
71CASK0.50849117
72PIK3CA0.49678192
73ALK0.49644038
74SYK0.49052587
75MAP2K60.47821857
76TNK20.47063614
77CSNK2A20.45941210
78CHEK20.42548862
79RPS6KA50.42099176
80PLK10.40729797
81TGFBR10.38148534
82PHKG20.37953866
83PHKG10.37953866
84MAP2K20.37538185
85CSNK2A10.35947670
86CSNK1G30.35514444
87MAP2K70.34808233
88ATR0.34593861
89ATM0.32422350
90CSNK1E0.31653301
91IGF1R0.31562246
92PRKACA0.31296015
93CAMK10.31124173
94MST40.30349926
95CSNK1G20.30127485
96CAMK2D0.29840843
97PRKCI0.28714132
98CSNK1A1L0.28268459
99PASK0.27980977
100TAOK20.27649398

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.26409770
2Oxidative phosphorylation_Homo sapiens_hsa001903.27566054
3RNA polymerase_Homo sapiens_hsa030202.92532148
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81438183
5Parkinsons disease_Homo sapiens_hsa050122.70119588
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34003561
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31202009
8Homologous recombination_Homo sapiens_hsa034402.28826096
9Proteasome_Homo sapiens_hsa030502.28673549
10Linoleic acid metabolism_Homo sapiens_hsa005912.16577370
11Huntingtons disease_Homo sapiens_hsa050162.08693019
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04205404
13Alzheimers disease_Homo sapiens_hsa050101.84194190
14Pyrimidine metabolism_Homo sapiens_hsa002401.82756558
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82271610
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81580920
17RNA degradation_Homo sapiens_hsa030181.78921425
18Caffeine metabolism_Homo sapiens_hsa002321.77364802
19DNA replication_Homo sapiens_hsa030301.76512377
20Cardiac muscle contraction_Homo sapiens_hsa042601.76091116
21Phototransduction_Homo sapiens_hsa047441.75829526
22Spliceosome_Homo sapiens_hsa030401.75806405
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75679868
24Selenocompound metabolism_Homo sapiens_hsa004501.72013786
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65675138
26Nitrogen metabolism_Homo sapiens_hsa009101.65557270
27One carbon pool by folate_Homo sapiens_hsa006701.51097483
28Protein export_Homo sapiens_hsa030601.45242179
29Fanconi anemia pathway_Homo sapiens_hsa034601.41687276
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39863820
31Purine metabolism_Homo sapiens_hsa002301.31905546
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28297792
33Butanoate metabolism_Homo sapiens_hsa006501.27760772
34Tryptophan metabolism_Homo sapiens_hsa003801.21130654
35Propanoate metabolism_Homo sapiens_hsa006401.19621220
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17336666
37Mismatch repair_Homo sapiens_hsa034301.15638585
38Ether lipid metabolism_Homo sapiens_hsa005651.14956505
39Peroxisome_Homo sapiens_hsa041461.13136554
40Sulfur metabolism_Homo sapiens_hsa009201.12616927
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.11982190
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10588969
43Basal transcription factors_Homo sapiens_hsa030221.06739838
44Chemical carcinogenesis_Homo sapiens_hsa052041.04406394
45Arachidonic acid metabolism_Homo sapiens_hsa005901.01558509
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00392097
47Base excision repair_Homo sapiens_hsa034100.94565447
48RNA transport_Homo sapiens_hsa030130.93586933
49Asthma_Homo sapiens_hsa053100.89233224
50Nucleotide excision repair_Homo sapiens_hsa034200.84450657
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83346165
52Folate biosynthesis_Homo sapiens_hsa007900.81732765
53Metabolic pathways_Homo sapiens_hsa011000.81516381
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.78489291
55Ovarian steroidogenesis_Homo sapiens_hsa049130.77599675
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74659467
57Retinol metabolism_Homo sapiens_hsa008300.72237124
58Nicotine addiction_Homo sapiens_hsa050330.72070742
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.69285617
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65842980
61Graft-versus-host disease_Homo sapiens_hsa053320.65518726
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65385852
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.64757994
64Primary immunodeficiency_Homo sapiens_hsa053400.62078669
65Systemic lupus erythematosus_Homo sapiens_hsa053220.60339599
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59926902
67Antigen processing and presentation_Homo sapiens_hsa046120.58916560
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58255810
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58212073
70Fat digestion and absorption_Homo sapiens_hsa049750.58111013
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57907059
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.54861502
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54271650
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50274895
75Fatty acid degradation_Homo sapiens_hsa000710.49689741
76Glutathione metabolism_Homo sapiens_hsa004800.47399224
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.46724007
78Taste transduction_Homo sapiens_hsa047420.46054470
79Fatty acid metabolism_Homo sapiens_hsa012120.46010679
80Regulation of autophagy_Homo sapiens_hsa041400.45866704
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43028610
82Collecting duct acid secretion_Homo sapiens_hsa049660.40871544
83mRNA surveillance pathway_Homo sapiens_hsa030150.40685363
84ABC transporters_Homo sapiens_hsa020100.39497074
85Allograft rejection_Homo sapiens_hsa053300.36862902
86Other glycan degradation_Homo sapiens_hsa005110.36812314
87Morphine addiction_Homo sapiens_hsa050320.36004195
88Type I diabetes mellitus_Homo sapiens_hsa049400.33399980
89Serotonergic synapse_Homo sapiens_hsa047260.31644166
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29979845
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29584381
92Olfactory transduction_Homo sapiens_hsa047400.29237163
93beta-Alanine metabolism_Homo sapiens_hsa004100.28476912
94N-Glycan biosynthesis_Homo sapiens_hsa005100.27693810
95Vitamin digestion and absorption_Homo sapiens_hsa049770.26110634
96Autoimmune thyroid disease_Homo sapiens_hsa053200.24838981
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.24707978
98Pyruvate metabolism_Homo sapiens_hsa006200.22176834
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.21741779
100Glycerolipid metabolism_Homo sapiens_hsa005610.21449545

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