ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.93486052
2	maturation of SSU-rRNA (GO:0030490)	8.70044069
3	viral transcription (GO:0019083)	8.44691296
4	translational termination (GO:0006415)	7.94489790
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.76928946
6	translational elongation (GO:0006414)	6.76418813
7	cotranslational protein targeting to membrane (GO:0006613)	6.67784070
8	protein targeting to ER (GO:0045047)	6.62049224
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.30094623
10	protein localization to endoplasmic reticulum (GO:0070972)	6.21379829
11	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.05563470
12	cellular protein complex disassembly (GO:0043624)	5.94951532
13	viral life cycle (GO:0019058)	5.92571433
14	chaperone-mediated protein transport (GO:0072321)	5.87495393
15	translational initiation (GO:0006413)	5.52428146
16	ncRNA 3-end processing (GO:0043628)	5.50229613
17	protein complex disassembly (GO:0043241)	5.06713715
18	ribonucleoprotein complex biogenesis (GO:0022613)	4.78986360
19	ribosomal large subunit biogenesis (GO:0042273)	4.77255628
20	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.76903816
21	macromolecular complex disassembly (GO:0032984)	4.70170028
22	translation (GO:0006412)	4.56927543
23	protein targeting to membrane (GO:0006612)	4.50042015
24	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.42199054
25	deoxyribose phosphate biosynthetic process (GO:0046385)	4.42199054
26	cellular component biogenesis (GO:0044085)	4.29319696
27	ATP synthesis coupled proton transport (GO:0015986)	4.28619141
28	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28619141
29	protein neddylation (GO:0045116)	4.25457744
30	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.15953842
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.12823651
32	ubiquinone biosynthetic process (GO:0006744)	4.09269734
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.09102177
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.08882046
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.08882046
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.04182904
37	NADH dehydrogenase complex assembly (GO:0010257)	4.04182904
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.04182904
39	transcription from RNA polymerase I promoter (GO:0006360)	4.03309613
40	rRNA processing (GO:0006364)	3.97383592
41	mRNA catabolic process (GO:0006402)	3.91916185
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.90612558
43	formation of translation preinitiation complex (GO:0001731)	3.88818534
44	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.88736475
45	rRNA metabolic process (GO:0016072)	3.84589436
46	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.80452020
47	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.75923413
48	ubiquinone metabolic process (GO:0006743)	3.67488876
49	RNA catabolic process (GO:0006401)	3.60212323
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53083786
51	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.52248637
52	protein complex biogenesis (GO:0070271)	3.48925192
53	kinetochore assembly (GO:0051382)	3.46654135
54	regulation of mitochondrial translation (GO:0070129)	3.39732051
55	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.39439387
56	protein-cofactor linkage (GO:0018065)	3.35872101
57	cell proliferation in forebrain (GO:0021846)	3.32475639
58	GTP biosynthetic process (GO:0006183)	3.30721165
59	protein targeting to mitochondrion (GO:0006626)	3.27649790
60	quinone biosynthetic process (GO:1901663)	3.26537662
61	respiratory electron transport chain (GO:0022904)	3.24914234
62	UTP metabolic process (GO:0046051)	3.21316519
63	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20039883
64	electron transport chain (GO:0022900)	3.19338002
65	kinetochore organization (GO:0051383)	3.14308207
66	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.13863691
67	deoxyribonucleotide biosynthetic process (GO:0009263)	3.13415976
68	activated T cell proliferation (GO:0050798)	3.10403812
69	pyrimidine nucleotide catabolic process (GO:0006244)	3.09945524
70	pseudouridine synthesis (GO:0001522)	3.09544708
71	protein targeting (GO:0006605)	3.09420119
72	UTP biosynthetic process (GO:0006228)	3.07490511
73	ribosome biogenesis (GO:0042254)	3.04952094
74	establishment of protein localization to mitochondrion (GO:0072655)	3.03380815
75	ncRNA processing (GO:0034470)	3.03205525
76	response to nitrosative stress (GO:0051409)	3.02004089
77	establishment of protein localization to membrane (GO:0090150)	3.01073507
78	resolution of meiotic recombination intermediates (GO:0000712)	2.98353759
79	spermatid nucleus differentiation (GO:0007289)	2.97227833
80	diacylglycerol metabolic process (GO:0046339)	2.95297243
81	tRNA processing (GO:0008033)	2.94866573
82	regulation of cellular respiration (GO:0043457)	2.91979096
83	viral mRNA export from host cell nucleus (GO:0046784)	2.89443469
84	establishment of protein localization to organelle (GO:0072594)	2.88292206
85	protein localization to mitochondrion (GO:0070585)	2.86566657
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.82807783
87	oxidative phosphorylation (GO:0006119)	2.79849307
88	guanosine-containing compound biosynthetic process (GO:1901070)	2.79620802
89	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.79040025
90	replication fork processing (GO:0031297)	2.77755842
91	nonmotile primary cilium assembly (GO:0035058)	2.77170835
92	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.77167030
93	rRNA modification (GO:0000154)	2.75596115
94	regulation of protein glycosylation (GO:0060049)	2.75589823
95	positive regulation of glycoprotein metabolic process (GO:1903020)	2.73910864
96	protein localization to membrane (GO:0072657)	2.71833944
97	peptidyl-histidine modification (GO:0018202)	2.70377452
98	ATP biosynthetic process (GO:0006754)	2.67677241
99	intracellular protein transmembrane import (GO:0044743)	2.67128427
100	ribosomal small subunit assembly (GO:0000028)	11.0372351

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.76266787
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.29625262
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.16556822
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.44166164
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.39369095
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.33715992
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.28590632
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.12006190
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.81605111
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.71590939
11	XRN2_22483619_ChIP-Seq_HELA_Human	2.69590164
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.50166138
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.47964735
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40865480
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.38602194
16	TTF2_22483619_ChIP-Seq_HELA_Human	2.37637290
17	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.34556415
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34527490
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.32889624
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.23494196
21	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.23105883
22	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.04405915
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01278612
24	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.92780321
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.92492419
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.91635219
27	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.84506814
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.78736003
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78013934
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74719267
31	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.74440220
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.68475634
33	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.68395819
34	EZH2_22144423_ChIP-Seq_EOC_Human	1.60945839
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57800623
36	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53675169
37	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.51709689
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43803860
39	BCL6_27268052_Chip-Seq_Bcells_Human	1.34602101
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34394391
41	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.31997268
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.31561452
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.29516921
44	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.28396196
45	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28109856
46	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.26815102
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25783033
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25564480
49	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.23495776
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.22573833
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.22169096
52	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.21729838
53	P68_20966046_ChIP-Seq_HELA_Human	1.20147379
54	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19147787
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19053361
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.18830634
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.18012466
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.17141310
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16637194
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16544490
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.13692005
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13683649
63	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.10755703
64	PHF8_20622854_ChIP-Seq_HELA_Human	1.09856598
65	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.09673574
66	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.09118555
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09010244
68	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.08523922
69	VDR_21846776_ChIP-Seq_THP-1_Human	1.07846340
70	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07056336
71	SA1_27219007_Chip-Seq_Bcells_Human	1.05309693
72	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04393950
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.03576911
74	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.03060466
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03044633
76	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02508086
77	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.02137578
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00955407
79	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.99013708
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.98939294
81	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98279524
82	BCOR_27268052_Chip-Seq_Bcells_Human	0.97653432
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96207507
84	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96101852
85	ERA_21632823_ChIP-Seq_H3396_Human	0.95320281
86	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.94328464
87	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.91546597
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.90289857
89	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.89106631
90	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.88034911
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87881860
92	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87188976
93	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.86732955
94	P300_27268052_Chip-Seq_Bcells_Human	0.86697910
95	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.86179007
96	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.86113053
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.85913562
98	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.85792363
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.84495257
100	E2F7_22180533_ChIP-Seq_HELA_Human	0.84163135

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.00897295
2	MP0006292_abnormal_olfactory_placode	5.40000513
3	MP0002163_abnormal_gland_morphology	3.31095293
4	MP0002234_abnormal_pharynx_morphology	2.77255911
5	MP0003646_muscle_fatigue	2.54399089
6	MP0008789_abnormal_olfactory_epithelium	2.35572873
7	MP0002160_abnormal_reproductive_system	2.15460084
8	MP0005394_taste/olfaction_phenotype	2.12267660
9	MP0005499_abnormal_olfactory_system	2.12267660
10	MP0000049_abnormal_middle_ear	2.11698835
11	MP0004142_abnormal_muscle_tone	2.08599162
12	MP0003693_abnormal_embryo_hatching	2.07888019
13	MP0005646_abnormal_pituitary_gland	2.05082040
14	MP0005379_endocrine/exocrine_gland_phen	1.98190656
15	MP0001293_anophthalmia	1.87591409
16	MP0001529_abnormal_vocalization	1.78494198
17	MP0005670_abnormal_white_adipose	1.71177896
18	MP0003123_paternal_imprinting	1.69489371
19	MP0001905_abnormal_dopamine_level	1.53780966
20	MP0005389_reproductive_system_phenotype	1.51763072
21	MP0002933_joint_inflammation	1.51671375
22	MP0000678_abnormal_parathyroid_gland	1.50942385
23	MP0003186_abnormal_redox_activity	1.49660588
24	MP0002876_abnormal_thyroid_physiology	1.40536188
25	MP0002249_abnormal_larynx_morphology	1.36012481
26	MP0001348_abnormal_lacrimal_gland	1.33056697
27	MP0002277_abnormal_respiratory_mucosa	1.32812925
28	MP0006036_abnormal_mitochondrial_physio	1.32562764
29	MP0003786_premature_aging	1.29575464
30	MP0002822_catalepsy	1.25414196
31	MP0001188_hyperpigmentation	1.25180146
32	MP0009250_abnormal_appendicular_skeleto	1.24452057
33	MP0004885_abnormal_endolymph	1.23164818
34	MP0002102_abnormal_ear_morphology	1.21274199
35	MP0000631_abnormal_neuroendocrine_gland	1.18329788
36	MP0008058_abnormal_DNA_repair	1.17170364
37	MP0009053_abnormal_anal_canal	1.16720950
38	MP0003567_abnormal_fetal_cardiomyocyte	1.16668118
39	MP0002095_abnormal_skin_pigmentation	1.16382700
40	MP0008007_abnormal_cellular_replicative	1.16352905
41	MP0001851_eye_inflammation	1.14732279
42	MP0003806_abnormal_nucleotide_metabolis	1.12847230
43	MP0003937_abnormal_limbs/digits/tail_de	1.12789478
44	MP0002210_abnormal_sex_determination	1.09204303
45	MP0000750_abnormal_muscle_regeneration	1.09068471
46	MP0001919_abnormal_reproductive_system	1.06798647
47	MP0002938_white_spotting	1.04106620
48	MP0006276_abnormal_autonomic_nervous	1.03588469
49	MP0000566_synostosis	1.03514764
50	MP0003111_abnormal_nucleus_morphology	1.02871746
51	MP0001727_abnormal_embryo_implantation	1.02204968
52	MP0001986_abnormal_taste_sensitivity	1.01257508
53	MP0005253_abnormal_eye_physiology	1.01120507
54	MP0004957_abnormal_blastocyst_morpholog	1.00175329
55	MP0004147_increased_porphyrin_level	0.96753158
56	MP0003011_delayed_dark_adaptation	0.94864675
57	MP0008872_abnormal_physiological_respon	0.93820792
58	MP0009278_abnormal_bone_marrow	0.93690881
59	MP0008995_early_reproductive_senescence	0.93514193
60	MP0002837_dystrophic_cardiac_calcinosis	0.93450560
61	MP0005195_abnormal_posterior_eye	0.92901648
62	MP0005197_abnormal_uvea_morphology	0.92048019
63	MP0002132_abnormal_respiratory_system	0.91002050
64	MP0005645_abnormal_hypothalamus_physiol	0.87655522
65	MP0005391_vision/eye_phenotype	0.86690501
66	MP0003942_abnormal_urinary_system	0.85238336
67	MP0008875_abnormal_xenobiotic_pharmacok	0.84726031
68	MP0009333_abnormal_splenocyte_physiolog	0.84713662
69	MP0002638_abnormal_pupillary_reflex	0.83931726
70	MP0004145_abnormal_muscle_electrophysio	0.83551687
71	MP0008877_abnormal_DNA_methylation	0.82899875
72	MP0005551_abnormal_eye_electrophysiolog	0.82527221
73	MP0002736_abnormal_nociception_after	0.82447194
74	MP0001145_abnormal_male_reproductive	0.81878757
75	MP0003787_abnormal_imprinting	0.81408226
76	MP0001968_abnormal_touch/_nociception	0.79507078
77	MP0002697_abnormal_eye_size	0.77172000
78	MP0003755_abnormal_palate_morphology	0.76936920
79	MP0000653_abnormal_sex_gland	0.76797408
80	MP0000955_abnormal_spinal_cord	0.75853346
81	MP0010386_abnormal_urinary_bladder	0.75720720
82	MP0002752_abnormal_somatic_nervous	0.74601283
83	MP0005084_abnormal_gallbladder_morpholo	0.73545516
84	MP0002733_abnormal_thermal_nociception	0.73522208
85	MP0001440_abnormal_grooming_behavior	0.72345034
86	MP0002233_abnormal_nose_morphology	0.72327611
87	MP0010094_abnormal_chromosome_stability	0.72234267
88	MP0005408_hypopigmentation	0.72198379
89	MP0003938_abnormal_ear_development	0.70648341
90	MP0005193_abnormal_anterior_eye	0.69995623
91	MP0002184_abnormal_innervation	0.68984728
92	MP0005360_urolithiasis	0.68591208
93	MP0001191_abnormal_skin_condition	0.68513475
94	MP0004185_abnormal_adipocyte_glucose	0.68143995
95	MP0001800_abnormal_humoral_immune	0.67899954
96	MP0000026_abnormal_inner_ear	0.67802221
97	MP0003121_genomic_imprinting	0.67578104
98	MP0000470_abnormal_stomach_morphology	0.67114643
99	MP0003878_abnormal_ear_physiology	0.66757564
100	MP0005377_hearing/vestibular/ear_phenot	0.66757564

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the sacrum (HP:0008517)	6.35925695
2	Reticulocytopenia (HP:0001896)	6.31062120
3	Acute necrotizing encephalopathy (HP:0006965)	4.72204875
4	Recurrent gram-negative bacterial infections (HP:0005420)	4.49296781
5	Abnormality of cells of the erythroid lineage (HP:0012130)	4.38567859
6	Acute encephalopathy (HP:0006846)	4.34188446
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.32414384
8	Macrocytic anemia (HP:0001972)	4.08752998
9	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.73793432
10	Progressive macrocephaly (HP:0004481)	3.68713937
11	Abnormal number of erythroid precursors (HP:0012131)	3.53258816
12	Pallor (HP:0000980)	3.48694923
13	Hyperglycinemia (HP:0002154)	3.42993713
14	Mitochondrial inheritance (HP:0001427)	3.41556768
15	3-Methylglutaconic aciduria (HP:0003535)	3.33589593
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.31205571
17	Maternal diabetes (HP:0009800)	3.15160038
18	Periodontitis (HP:0000704)	3.05521724
19	Cerebral edema (HP:0002181)	2.87913874
20	Partial duplication of thumb phalanx (HP:0009944)	2.86968635
21	11 pairs of ribs (HP:0000878)	2.85594400
22	Constricted visual fields (HP:0001133)	2.84776692
23	Chronic bronchitis (HP:0004469)	2.82395652
24	Abnormality of the aortic arch (HP:0012303)	2.81506328
25	Increased CSF lactate (HP:0002490)	2.79992813
26	Nasal speech (HP:0001611)	2.78671532
27	Microretrognathia (HP:0000308)	2.76157294
28	Absent thumb (HP:0009777)	2.74994296
29	Abnormality of the intervertebral disk (HP:0005108)	2.70302671
30	Leukocytosis (HP:0001974)	2.69321738
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.69046513
32	Partial duplication of the phalanx of hand (HP:0009999)	2.60488211
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.55619581
34	Pendular nystagmus (HP:0012043)	2.53582408
35	Optic disc pallor (HP:0000543)	2.51089148
36	Hepatocellular necrosis (HP:0001404)	2.50796388
37	Increased IgM level (HP:0003496)	2.48370303
38	B lymphocytopenia (HP:0010976)	2.46249081
39	Sparse scalp hair (HP:0002209)	2.44530726
40	Panhypogammaglobulinemia (HP:0003139)	2.41411578
41	Recurrent abscess formation (HP:0002722)	2.41379844
42	Increased serum lactate (HP:0002151)	2.40961451
43	Abnormality of alanine metabolism (HP:0010916)	2.39640529
44	Hyperalaninemia (HP:0003348)	2.39640529
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39640529
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36763178
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36763178
48	Cortical visual impairment (HP:0100704)	2.35525056
49	Cerebellar dysplasia (HP:0007033)	2.28799938
50	Eosinophilia (HP:0001880)	2.24101938
51	Hypoplasia of the radius (HP:0002984)	2.22197372
52	Lactic acidosis (HP:0003128)	2.21351694
53	Hypoproteinemia (HP:0003075)	2.20553019
54	Abnormality of midbrain morphology (HP:0002418)	2.19605104
55	Molar tooth sign on MRI (HP:0002419)	2.19605104
56	Abnormality of the phalanges of the hallux (HP:0010057)	2.18996872
57	Anencephaly (HP:0002323)	2.18941211
58	Abnormality of B cell number (HP:0010975)	2.18349440
59	Abnormality of DNA repair (HP:0003254)	2.15420306
60	Asplenia (HP:0001746)	2.11968491
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.09381043
62	Abolished electroretinogram (ERG) (HP:0000550)	2.08813836
63	Hepatic necrosis (HP:0002605)	2.08374916
64	Attenuation of retinal blood vessels (HP:0007843)	2.06062523
65	Abnormal respiratory motile cilium physiology (HP:0012261)	2.05700605
66	Triphalangeal thumb (HP:0001199)	2.05210890
67	Broad distal phalanx of finger (HP:0009836)	2.03723668
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02992216
69	Colon cancer (HP:0003003)	1.99126554
70	Exercise intolerance (HP:0003546)	1.96701001
71	Granulocytopenia (HP:0001913)	1.96435293
72	Stenosis of the external auditory canal (HP:0000402)	1.95406526
73	Congenital stationary night blindness (HP:0007642)	1.92942420
74	Renal Fanconi syndrome (HP:0001994)	1.90187337
75	Gingivitis (HP:0000230)	1.88347009
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.88151371
77	Abnormal number of incisors (HP:0011064)	1.85180921
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.85122003
79	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.85023480
80	Rib fusion (HP:0000902)	1.84935550
81	Abnormality of eosinophils (HP:0001879)	1.83012152
82	Pancytopenia (HP:0001876)	1.82920854
83	Leukodystrophy (HP:0002415)	1.82803621
84	Duplication of thumb phalanx (HP:0009942)	1.82698847
85	Severe combined immunodeficiency (HP:0004430)	1.78324945
86	Increased hepatocellular lipid droplets (HP:0006565)	1.77034170
87	Deep philtrum (HP:0002002)	1.74571050
88	Increased intramyocellular lipid droplets (HP:0012240)	1.74461415
89	Abnormality of magnesium homeostasis (HP:0004921)	1.73771814
90	Progressive muscle weakness (HP:0003323)	1.73248026
91	Lethargy (HP:0001254)	1.72207638
92	Septo-optic dysplasia (HP:0100842)	1.71999702
93	Cupped ribs (HP:0000887)	1.69329768
94	Chorioretinal atrophy (HP:0000533)	1.69097057
95	Depressed nasal ridge (HP:0000457)	1.68682819
96	Respiratory failure (HP:0002878)	1.67817454
97	Partial agenesis of the corpus callosum (HP:0001338)	1.66518279
98	Abnormality of the renal collecting system (HP:0004742)	1.65615360
99	Abnormal hemoglobin (HP:0011902)	1.64736505
100	Sclerocornea (HP:0000647)	1.63226073

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	5.69117280
2	PRKCH	4.05301569
3	STK16	3.79544331
4	MAP4K1	3.46071888
5	NME2	3.36542406
6	VRK2	3.12864033
7	TYRO3	2.84213038
8	DYRK2	2.32850524
9	TXK	2.32785673
10	TIE1	2.17916479
11	MAP3K11	2.03739935
12	BCKDK	2.03354168
13	CDC7	2.00351222
14	ZAK	1.99442873
15	FES	1.92360650
16	GRK1	1.60120684
17	ICK	1.59680372
18	SMG1	1.59462939
19	DAPK1	1.42980195
20	WNK4	1.32451925
21	BUB1	1.24740255
22	NUAK1	1.23095256
23	TAF1	1.21495008
24	KDR	1.21044446
25	TLK1	1.19480345
26	TAOK3	1.15223241
27	CDK19	1.13845847
28	ABL2	1.12774604
29	AURKA	1.12421482
30	PINK1	1.11669572
31	SRPK1	1.09714890
32	LRRK2	1.00835987
33	RPS6KA6	0.93999822
34	VRK1	0.92804982
35	RPS6KC1	0.92354931
36	RPS6KL1	0.92354931
37	ADRBK2	0.89723679
38	CHEK2	0.84944948
39	MAP2K3	0.83609305
40	MUSK	0.80851715
41	BRAF	0.79700026
42	CSNK2A2	0.76133380
43	PRKCD	0.76040113
44	CSNK1G3	0.75826294
45	MAP2K7	0.75436514
46	ATR	0.74962121
47	BMPR1B	0.74269814
48	PRKCQ	0.73464837
49	PRKCI	0.72666077
50	PLK1	0.72561589
51	CAMK1	0.70438972
52	PIM2	0.67983086
53	MAP3K8	0.66338214
54	CDK9	0.65718390
55	NME1	0.63665485
56	ADRBK1	0.61430991
57	RPS6KA5	0.60953505
58	CSK	0.60295316
59	STK11	0.59821753
60	MAP2K2	0.59436986
61	IKBKB	0.59385249
62	RPS6KB2	0.59016045
63	RPS6KA2	0.58803143
64	STK4	0.58190904
65	TESK2	0.58140884
66	LCK	0.55970647
67	CSNK2A1	0.55850272
68	DYRK1B	0.55301327
69	PRKCG	0.55230147
70	PIM1	0.54515772
71	AURKB	0.54306718
72	DAPK3	0.54113295
73	CSNK1E	0.52158208
74	CSNK1A1	0.52106311
75	ILK	0.50870687
76	PIK3CG	0.50457951
77	MAP4K2	0.48316444
78	PRKACA	0.47328505
79	CSNK1G1	0.47231729
80	PHKG2	0.46380275
81	PHKG1	0.46380275
82	CAMK2G	0.46058403
83	PAK1	0.45937109
84	ATM	0.45931792
85	PDK2	0.45844927
86	OBSCN	0.45137771
87	CSNK1A1L	0.44455608
88	RPS6KA1	0.43420038
89	RPS6KB1	0.43179340
90	CDK8	0.42348786
91	EPHB2	0.41135518
92	MAPK4	0.41068377
93	PLK4	0.40912387
94	RPS6KA4	0.40180390
95	CHEK1	0.39803261
96	CSNK1G2	0.39311757
97	TEC	0.37312129
98	PASK	0.36965103
99	CDK7	0.36112782
100	AKT2	0.35283311

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.20504027
2	RNA polymerase_Homo sapiens_hsa03020	5.08141103
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.55920885
4	Parkinsons disease_Homo sapiens_hsa05012	3.28444578
5	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.86280107
6	Sulfur relay system_Homo sapiens_hsa04122	2.58976295
7	Pyrimidine metabolism_Homo sapiens_hsa00240	2.49309545
8	Spliceosome_Homo sapiens_hsa03040	2.35316594
9	Huntingtons disease_Homo sapiens_hsa05016	2.33916212
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.29501801
11	DNA replication_Homo sapiens_hsa03030	2.22139605
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.17810128
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.02017502
14	Alzheimers disease_Homo sapiens_hsa05010	1.95034374
15	Purine metabolism_Homo sapiens_hsa00230	1.66362692
16	Mismatch repair_Homo sapiens_hsa03430	1.64721650
17	One carbon pool by folate_Homo sapiens_hsa00670	1.63135684
18	Homologous recombination_Homo sapiens_hsa03440	1.57224662
19	Proteasome_Homo sapiens_hsa03050	1.56792735
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52574983
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.52420774
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.51053921
23	Base excision repair_Homo sapiens_hsa03410	1.48331511
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47662544
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.42353031
26	RNA transport_Homo sapiens_hsa03013	1.42055463
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28682041
28	Basal transcription factors_Homo sapiens_hsa03022	1.27710839
29	RNA degradation_Homo sapiens_hsa03018	1.24313864
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21484233
31	Protein export_Homo sapiens_hsa03060	1.13044354
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.10774544
33	Allograft rejection_Homo sapiens_hsa05330	1.06284095
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04214715
35	Viral myocarditis_Homo sapiens_hsa05416	1.04016633
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02580833
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98801684
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94628892
39	Glutathione metabolism_Homo sapiens_hsa00480	0.93420709
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.83934682
41	Fat digestion and absorption_Homo sapiens_hsa04975	0.83157284
42	Phototransduction_Homo sapiens_hsa04744	0.75897608
43	Metabolic pathways_Homo sapiens_hsa01100	0.75588038
44	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.75481876
45	Malaria_Homo sapiens_hsa05144	0.72720129
46	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71510846
47	Folate biosynthesis_Homo sapiens_hsa00790	0.65938535
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.64109315
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62652527
50	Olfactory transduction_Homo sapiens_hsa04740	0.60688407
51	Legionellosis_Homo sapiens_hsa05134	0.58068301
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57936505
53	Peroxisome_Homo sapiens_hsa04146	0.56766093
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56538606
55	Fatty acid elongation_Homo sapiens_hsa00062	0.55392966
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55285906
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53972216
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51149166
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50445769
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49692603
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.48644267
62	Carbon metabolism_Homo sapiens_hsa01200	0.46589641
63	Asthma_Homo sapiens_hsa05310	0.43459775
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42440883
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.41341472
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41206161
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40812242
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.40117240
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39660227
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38787769
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38131954
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.37971198
73	Leishmaniasis_Homo sapiens_hsa05140	0.37573072
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35997209
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35006499
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33821811
77	Sulfur metabolism_Homo sapiens_hsa00920	0.33278747
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33075781
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31912269
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31387056
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28641999
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.27608651
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23184113
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.23128699
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23119368
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.22842414
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.18216335
88	Non-small cell lung cancer_Homo sapiens_hsa05223	0.18057703
89	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18044306
90	Nitrogen metabolism_Homo sapiens_hsa00910	0.16070783
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.15799233
92	Melanoma_Homo sapiens_hsa05218	0.15565671
93	Propanoate metabolism_Homo sapiens_hsa00640	0.13204408
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.11299199
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.10975772
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.10853040
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.10838150
98	Galactose metabolism_Homo sapiens_hsa00052	0.10695790
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.09995356
100	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.09822820

RPS2P55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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