ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.52177515
2	ribosomal small subunit biogenesis (GO:0042274)	8.22150466
3	translational termination (GO:0006415)	8.16115391
4	ribosomal small subunit assembly (GO:0000028)	8.01923971
5	maturation of SSU-rRNA (GO:0030490)	7.83466208
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.84323131
7	translational elongation (GO:0006414)	6.78690310
8	cotranslational protein targeting to membrane (GO:0006613)	6.71917036
9	protein targeting to ER (GO:0045047)	6.70863127
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.43049725
11	protein localization to endoplasmic reticulum (GO:0070972)	6.32173393
12	cellular protein complex disassembly (GO:0043624)	6.19254844
13	viral life cycle (GO:0019058)	6.12770452
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.92146895
15	protein neddylation (GO:0045116)	5.75106266
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.30597819
17	ATP synthesis coupled proton transport (GO:0015986)	5.30597819
18	ribosomal large subunit biogenesis (GO:0042273)	5.23209473
19	protein complex disassembly (GO:0043241)	5.16350763
20	translational initiation (GO:0006413)	5.15341289
21	macromolecular complex disassembly (GO:0032984)	4.89354240
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.65114692
23	protein targeting to membrane (GO:0006612)	4.60955294
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.32859607
25	translation (GO:0006412)	4.16096809
26	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.15997464
27	respiratory electron transport chain (GO:0022904)	3.98995473
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.94627842
29	electron transport chain (GO:0022900)	3.92667467
30	mRNA catabolic process (GO:0006402)	3.92666040
31	regulation of mitochondrial translation (GO:0070129)	3.73591651
32	protein complex biogenesis (GO:0070271)	3.69753203
33	behavioral response to nicotine (GO:0035095)	3.68555379
34	ribonucleoprotein complex biogenesis (GO:0022613)	3.53140269
35	chaperone-mediated protein transport (GO:0072321)	3.51728178
36	NADH dehydrogenase complex assembly (GO:0010257)	3.51502279
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.51502279
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.51502279
39	RNA catabolic process (GO:0006401)	3.49009641
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44931169
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44931169
42	cellular component biogenesis (GO:0044085)	3.44103325
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.42359389
44	regulation of mitotic spindle checkpoint (GO:1903504)	3.42359389
45	axoneme assembly (GO:0035082)	3.41958489
46	substrate-independent telencephalic tangential migration (GO:0021826)	3.37243852
47	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.37243852
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33103859
49	piRNA metabolic process (GO:0034587)	3.30304256
50	epithelial cilium movement (GO:0003351)	3.25862029
51	cell proliferation in forebrain (GO:0021846)	3.21916775
52	response to redox state (GO:0051775)	3.21681916
53	GTP biosynthetic process (GO:0006183)	3.13397112
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.10130202
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04639052
56	thalamus development (GO:0021794)	3.04276704
57	establishment of protein localization to membrane (GO:0090150)	3.00089420
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.95571853
59	forebrain morphogenesis (GO:0048853)	2.95153797
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.94531510
61	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.93665703
62	regulation of action potential (GO:0098900)	2.91496821
63	myeloid cell homeostasis (GO:0002262)	2.90850821
64	rRNA processing (GO:0006364)	2.90410685
65	ATP biosynthetic process (GO:0006754)	2.89942823
66	protein targeting (GO:0006605)	2.89753363
67	rRNA metabolic process (GO:0016072)	2.86913128
68	hydrogen ion transmembrane transport (GO:1902600)	2.86903895
69	DNA deamination (GO:0045006)	2.85742583
70	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.82430432
71	DNA methylation involved in gamete generation (GO:0043046)	2.80508952
72	proteasome assembly (GO:0043248)	2.80052909
73	regulation of cellular respiration (GO:0043457)	2.79995505
74	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.79804913
75	DNA damage response, detection of DNA damage (GO:0042769)	2.72263946
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.69018957
77	regulation of uterine smooth muscle contraction (GO:0070472)	2.67825597
78	tRNA processing (GO:0008033)	2.66905824
79	establishment of protein localization to organelle (GO:0072594)	2.66403953
80	CTP biosynthetic process (GO:0006241)	2.65493687
81	CTP metabolic process (GO:0046036)	2.65493687
82	urate metabolic process (GO:0046415)	2.64991710
83	positive regulation of prostaglandin secretion (GO:0032308)	2.62957539
84	viral protein processing (GO:0019082)	2.61919295
85	positive regulation of respiratory burst (GO:0060267)	2.60880134
86	proton transport (GO:0015992)	2.59728917
87	transmission of nerve impulse (GO:0019226)	2.58872343
88	negative regulation of heart rate (GO:0010459)	2.56401365
89	pattern specification involved in kidney development (GO:0061004)	2.55169043
90	endoderm formation (GO:0001706)	2.54482794
91	hydrogen transport (GO:0006818)	2.53470801
92	UTP biosynthetic process (GO:0006228)	2.53431306
93	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.53084269
94	positive regulation of fatty acid transport (GO:2000193)	2.49129795
95	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.47210854
96	positive regulation of action potential (GO:0045760)	2.45873318
97	rRNA catabolic process (GO:0016075)	2.45448638
98	somite development (GO:0061053)	2.44313603
99	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.42027451
100	metallo-sulfur cluster assembly (GO:0031163)	2.40836795

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.50921158
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.29496528
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.93426852
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.62882485
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.47037196
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.98637390
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95721518
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.89737206
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84458747
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.83401476
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73892750
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.67439851
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.55674967
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48943949
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.48132141
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.38814851
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.36181829
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.18898672
19	TTF2_22483619_ChIP-Seq_HELA_Human	2.07914077
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.06240640
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.99472587
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93346070
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.89591700
24	XRN2_22483619_ChIP-Seq_HELA_Human	1.81796229
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79356049
26	VDR_22108803_ChIP-Seq_LS180_Human	1.77742733
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75561669
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.67452328
29	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.65282579
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58046901
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.54806360
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54397216
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.48538781
34	GATA1_22025678_ChIP-Seq_K562_Human	1.44408168
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43422425
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42738683
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42040868
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41181777
39	ERA_21632823_ChIP-Seq_H3396_Human	1.38010402
40	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.32780663
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.32655831
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.32362065
43	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.31316618
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.28489533
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27019486
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24667482
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22776380
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22726828
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.22436898
50	NCOR_22424771_ChIP-Seq_293T_Human	1.21896246
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20184135
52	AR_20517297_ChIP-Seq_VCAP_Human	1.19396848
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18286720
54	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.18122917
55	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.12967393
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12371083
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11188438
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11188438
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09496036
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07785058
61	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.06099048
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03296844
63	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02989333
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.02918881
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02683633
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00579781
67	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.00178703
68	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.98274326
69	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97645064
70	FUS_26573619_Chip-Seq_HEK293_Human	0.96935783
71	GABP_19822575_ChIP-Seq_HepG2_Human	0.96728782
72	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.96344569
73	BCL6_27268052_Chip-Seq_Bcells_Human	0.96341867
74	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95761195
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95384930
76	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92569919
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92438686
78	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.92383456
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91905848
80	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90406438
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.89316713
82	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89142079
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89069230
84	GATA3_26560356_Chip-Seq_TH2_Human	0.88504960
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87376862
86	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.86874661
87	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.86540644
88	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86427157
89	STAT1_20625510_ChIP-Seq_HELA_Human	0.85358006
90	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.84953768
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.84624639
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.84624639
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.84565607
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84254688
95	RNF2_27304074_Chip-Seq_NSC_Mouse	0.83455897
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.81812738
97	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81558718
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.81390011
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.81332717
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.79318709

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.44852448
2	MP0006292_abnormal_olfactory_placode	4.59805041
3	MP0002163_abnormal_gland_morphology	3.80816291
4	MP0004147_increased_porphyrin_level	2.70756285
5	MP0003878_abnormal_ear_physiology	2.62871089
6	MP0005377_hearing/vestibular/ear_phenot	2.62871089
7	MP0002653_abnormal_ependyma_morphology	2.41816612
8	MP0005379_endocrine/exocrine_gland_phen	2.40707232
9	MP0002138_abnormal_hepatobiliary_system	2.23337472
10	MP0003283_abnormal_digestive_organ	2.11760437
11	MP0004142_abnormal_muscle_tone	1.98507071
12	MP0005645_abnormal_hypothalamus_physiol	1.96247832
13	MP0004885_abnormal_endolymph	1.92841130
14	MP0001293_anophthalmia	1.89691869
15	MP0002837_dystrophic_cardiac_calcinosis	1.89630503
16	MP0003122_maternal_imprinting	1.76718068
17	MP0006072_abnormal_retinal_apoptosis	1.72939649
18	MP0003136_yellow_coat_color	1.72575528
19	MP0001968_abnormal_touch/_nociception	1.71514887
20	MP0002102_abnormal_ear_morphology	1.70408128
21	MP0002876_abnormal_thyroid_physiology	1.56485257
22	MP0002160_abnormal_reproductive_system	1.56187492
23	MP0005551_abnormal_eye_electrophysiolog	1.55803569
24	MP0000631_abnormal_neuroendocrine_gland	1.54684661
25	MP0005671_abnormal_response_to	1.54128631
26	MP0002938_white_spotting	1.51080622
27	MP0008875_abnormal_xenobiotic_pharmacok	1.50417509
28	MP0003646_muscle_fatigue	1.46857790
29	MP0005389_reproductive_system_phenotype	1.44365736
30	MP0008775_abnormal_heart_ventricle	1.44179472
31	MP0001485_abnormal_pinna_reflex	1.43472930
32	MP0000049_abnormal_middle_ear	1.42164247
33	MP0001502_abnormal_circadian_rhythm	1.39899099
34	MP0001764_abnormal_homeostasis	1.39242313
35	MP0001348_abnormal_lacrimal_gland	1.38556796
36	MP0001529_abnormal_vocalization	1.37712857
37	MP0005075_abnormal_melanosome_morpholog	1.34276258
38	MP0003186_abnormal_redox_activity	1.33578848
39	MP0004133_heterotaxia	1.29773075
40	MP0001919_abnormal_reproductive_system	1.29434448
41	MP0005646_abnormal_pituitary_gland	1.28094509
42	MP0006276_abnormal_autonomic_nervous	1.27660793
43	MP0005253_abnormal_eye_physiology	1.21947129
44	MP0001486_abnormal_startle_reflex	1.21826669
45	MP0003011_delayed_dark_adaptation	1.19270622
46	MP0000372_irregular_coat_pigmentation	1.19088434
47	MP0001905_abnormal_dopamine_level	1.18694421
48	MP0002557_abnormal_social/conspecific_i	1.13199243
49	MP0003787_abnormal_imprinting	1.12536484
50	MP0000778_abnormal_nervous_system	1.11779970
51	MP0002736_abnormal_nociception_after	1.11043534
52	MP0008877_abnormal_DNA_methylation	1.10308096
53	MP0002234_abnormal_pharynx_morphology	1.09394535
54	MP0002733_abnormal_thermal_nociception	1.06825946
55	MP0002277_abnormal_respiratory_mucosa	1.05774797
56	MP0001986_abnormal_taste_sensitivity	1.05765322
57	MP0003880_abnormal_central_pattern	1.03483470
58	MP0001970_abnormal_pain_threshold	0.98012259
59	MP0005195_abnormal_posterior_eye	0.95471642
60	MP0009745_abnormal_behavioral_response	0.95309550
61	MP0004019_abnormal_vitamin_homeostasis	0.94977532
62	MP0003724_increased_susceptibility_to	0.94738979
63	MP0003121_genomic_imprinting	0.94174624
64	MP0003123_paternal_imprinting	0.93269565
65	MP0003938_abnormal_ear_development	0.92282278
66	MP0003119_abnormal_digestive_system	0.90766609
67	MP0003718_maternal_effect	0.90242557
68	MP0006036_abnormal_mitochondrial_physio	0.87041799
69	MP0000566_synostosis	0.87035680
70	MP0000230_abnormal_systemic_arterial	0.86475796
71	MP0008872_abnormal_physiological_respon	0.86024880
72	MP0005167_abnormal_blood-brain_barrier	0.85320412
73	MP0002095_abnormal_skin_pigmentation	0.85096982
74	MP0001984_abnormal_olfaction	0.83536131
75	MP0002572_abnormal_emotion/affect_behav	0.83393372
76	MP0003693_abnormal_embryo_hatching	0.83005994
77	MP0002272_abnormal_nervous_system	0.82469655
78	MP0001963_abnormal_hearing_physiology	0.81449297
79	MP0004742_abnormal_vestibular_system	0.81431941
80	MP0000026_abnormal_inner_ear	0.79218953
81	MP0001440_abnormal_grooming_behavior	0.76388593
82	MP0002735_abnormal_chemical_nociception	0.75985412
83	MP0001501_abnormal_sleep_pattern	0.75537197
84	MP0005391_vision/eye_phenotype	0.74949183
85	MP0003937_abnormal_limbs/digits/tail_de	0.72843115
86	MP0002063_abnormal_learning/memory/cond	0.72773171
87	MP0000955_abnormal_spinal_cord	0.70973885
88	MP0008789_abnormal_olfactory_epithelium	0.70565246
89	MP0000427_abnormal_hair_cycle	0.69216272
90	MP0010030_abnormal_orbit_morphology	0.67491250
91	MP0006035_abnormal_mitochondrial_morpho	0.64726394
92	MP0002752_abnormal_somatic_nervous	0.64606063
93	MP0004924_abnormal_behavior	0.64307549
94	MP0005386_behavior/neurological_phenoty	0.64307549
95	MP0009764_decreased_sensitivity_to	0.64075223
96	MP0004130_abnormal_muscle_cell	0.61432845
97	MP0001765_abnormal_ion_homeostasis	0.60167823
98	MP0003950_abnormal_plasma_membrane	0.59414169
99	MP0001944_abnormal_pancreas_morphology	0.59392008
100	MP0001800_abnormal_humoral_immune	0.58960759

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.15812785
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.74782998
3	Pendular nystagmus (HP:0012043)	4.08622523
4	Abnormal number of erythroid precursors (HP:0012131)	4.04242334
5	Pancreatic cysts (HP:0001737)	3.89197539
6	Macrocytic anemia (HP:0001972)	3.86135770
7	3-Methylglutaconic aciduria (HP:0003535)	3.75661838
8	Mitochondrial inheritance (HP:0001427)	3.70775328
9	Acute necrotizing encephalopathy (HP:0006965)	3.63668045
10	Absent/shortened dynein arms (HP:0200106)	3.63168389
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.63168389
12	Acute encephalopathy (HP:0006846)	3.45429577
13	Pancreatic fibrosis (HP:0100732)	3.44057327
14	Abnormality of midbrain morphology (HP:0002418)	3.43194183
15	Molar tooth sign on MRI (HP:0002419)	3.43194183
16	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37251853
17	Increased CSF lactate (HP:0002490)	3.16070029
18	Hepatocellular necrosis (HP:0001404)	3.15684179
19	Increased hepatocellular lipid droplets (HP:0006565)	3.14247271
20	Generalized aminoaciduria (HP:0002909)	3.02855833
21	Hepatic necrosis (HP:0002605)	3.01838625
22	Progressive macrocephaly (HP:0004481)	2.99687485
23	Absent thumb (HP:0009777)	2.90146723
24	Pallor (HP:0000980)	2.85643031
25	Increased intramyocellular lipid droplets (HP:0012240)	2.83289802
26	Increased corneal curvature (HP:0100692)	2.82423478
27	Keratoconus (HP:0000563)	2.82423478
28	Lipid accumulation in hepatocytes (HP:0006561)	2.80822704
29	True hermaphroditism (HP:0010459)	2.71984324
30	Stenosis of the external auditory canal (HP:0000402)	2.62244890
31	Abolished electroretinogram (ERG) (HP:0000550)	2.60514485
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.60356044
33	Abnormal respiratory epithelium morphology (HP:0012253)	2.60356044
34	Congenital stationary night blindness (HP:0007642)	2.52284195
35	IgG deficiency (HP:0004315)	2.47941277
36	Increased serum lactate (HP:0002151)	2.44767422
37	Median cleft lip (HP:0000161)	2.44673204
38	Renal Fanconi syndrome (HP:0001994)	2.43699984
39	Partial duplication of thumb phalanx (HP:0009944)	2.42597286
40	Abnormality of urine glucose concentration (HP:0011016)	2.38123391
41	Glycosuria (HP:0003076)	2.38123391
42	Renal cortical cysts (HP:0000803)	2.37545860
43	Cystic liver disease (HP:0006706)	2.35790456
44	Posterior subcapsular cataract (HP:0007787)	2.35602351
45	Cerebral edema (HP:0002181)	2.34399663
46	Abnormal ciliary motility (HP:0012262)	2.33527740
47	Increased muscle lipid content (HP:0009058)	2.27697012
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22069721
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22048054
50	Abnormality of alanine metabolism (HP:0010916)	2.22048054
51	Hyperalaninemia (HP:0003348)	2.22048054
52	Colon cancer (HP:0003003)	2.18291305
53	Type II lissencephaly (HP:0007260)	2.16451454
54	Abnormality of the renal cortex (HP:0011035)	2.16139630
55	Increased IgM level (HP:0003496)	2.15543418
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.15487838
57	Rib fusion (HP:0000902)	2.13967858
58	Partial duplication of the phalanx of hand (HP:0009999)	2.12909818
59	Broad-based gait (HP:0002136)	2.12821866
60	Medial flaring of the eyebrow (HP:0010747)	2.12543344
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12281216
62	Septo-optic dysplasia (HP:0100842)	2.11939325
63	Myokymia (HP:0002411)	2.09563739
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.09519351
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.09519351
66	Attenuation of retinal blood vessels (HP:0007843)	2.07990213
67	Anencephaly (HP:0002323)	2.07722504
68	Optic disc pallor (HP:0000543)	2.07105709
69	Lactic acidosis (HP:0003128)	2.06999931
70	Constricted visual fields (HP:0001133)	2.06035561
71	Postaxial foot polydactyly (HP:0001830)	2.03864193
72	Hyperphosphaturia (HP:0003109)	2.02154733
73	Exertional dyspnea (HP:0002875)	2.01202930
74	Abnormality of DNA repair (HP:0003254)	1.99401612
75	Sclerocornea (HP:0000647)	1.95778294
76	Oligodactyly (hands) (HP:0001180)	1.94567287
77	Chorioretinal atrophy (HP:0000533)	1.93599223
78	Abnormality of the renal collecting system (HP:0004742)	1.91834119
79	Bile duct proliferation (HP:0001408)	1.91472677
80	Abnormal biliary tract physiology (HP:0012439)	1.91472677
81	Depressed nasal ridge (HP:0000457)	1.91009615
82	Congenital, generalized hypertrichosis (HP:0004540)	1.90540600
83	Optic nerve hypoplasia (HP:0000609)	1.90142445
84	Cerebellar dysplasia (HP:0007033)	1.88075886
85	Abnormality of B cell number (HP:0010975)	1.87979356
86	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.87652494
87	Abnormality of renal resorption (HP:0011038)	1.84990264
88	Hypoplasia of the radius (HP:0002984)	1.84898948
89	Duplication of thumb phalanx (HP:0009942)	1.84476948
90	Nephronophthisis (HP:0000090)	1.83653067
91	Deep palmar crease (HP:0006191)	1.83568330
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82632262
93	Triphalangeal thumb (HP:0001199)	1.77549552
94	Maternal diabetes (HP:0009800)	1.76378711
95	Severe visual impairment (HP:0001141)	1.76055130
96	Hyperglycinemia (HP:0002154)	1.75541780
97	Abnormality of the diencephalon (HP:0010662)	1.71825092
98	Postaxial hand polydactyly (HP:0001162)	1.70693377
99	Type 2 muscle fiber atrophy (HP:0003554)	1.70403314
100	Abnormality of the labia minora (HP:0012880)	1.70345730

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.59273671
2	TIE1	3.22382643
3	ZAK	2.72875124
4	ADRBK2	2.68710259
5	GRK1	2.64061629
6	TXK	2.41636226
7	INSRR	2.37126932
8	NUAK1	2.29864479
9	TLK1	2.27749955
10	ACVR1B	2.25041106
11	WNK4	2.14837866
12	MAP2K2	2.07396020
13	NEK2	2.02611748
14	GRK6	1.83294688
15	TAOK3	1.78826911
16	FRK	1.78826580
17	TNIK	1.68140518
18	BCKDK	1.64014984
19	PINK1	1.60283941
20	VRK2	1.59286003
21	SIK2	1.54513936
22	TEC	1.51569387
23	EPHA4	1.50961119
24	MAP4K2	1.45898625
25	ARAF	1.39946853
26	STK16	1.27942364
27	DYRK2	1.23341778
28	LIMK1	1.17012931
29	PASK	1.16009199
30	IKBKB	1.15895366
31	DAPK2	1.12777671
32	AURKA	1.08368649
33	CAMKK2	1.08109643
34	BMPR1B	1.06909105
35	TGFBR1	1.04800649
36	PIM2	1.04718359
37	MATK	1.02121874
38	BUB1	1.02108057
39	PDK2	0.99233886
40	STK39	0.98285648
41	PRKCG	0.97517869
42	PIK3CA	0.96555658
43	CSNK1G1	0.95906622
44	NLK	0.90891301
45	LRRK2	0.90715087
46	NEK1	0.90641739
47	RPS6KA6	0.86979766
48	MAP3K13	0.86786485
49	SYK	0.83585311
50	WNK3	0.81802744
51	PHKG2	0.81495481
52	PHKG1	0.81495481
53	CHEK2	0.81429447
54	MAP2K6	0.80192706
55	CSNK1G2	0.79992953
56	PRKCI	0.78038447
57	MAP3K9	0.76836183
58	PRKCQ	0.76377406
59	CSNK1G3	0.76211643
60	BTK	0.73982604
61	AURKB	0.73917567
62	MAP4K1	0.72014860
63	ADRBK1	0.71167585
64	NTRK2	0.70929323
65	OXSR1	0.70529069
66	NME2	0.70062801
67	DAPK3	0.69025230
68	KDR	0.68709148
69	BRAF	0.67578864
70	JAK3	0.65611182
71	RPS6KL1	0.64615850
72	RPS6KC1	0.64615850
73	CSNK2A2	0.64413134
74	ILK	0.63056031
75	PRKCH	0.59999089
76	NTRK1	0.59194615
77	PRKCD	0.59076466
78	ITK	0.58476917
79	RPS6KA5	0.57978672
80	VRK1	0.57662066
81	MARK1	0.56652791
82	TRIM28	0.55438812
83	CAMK1	0.53757433
84	CAMK1D	0.53400313
85	BCR	0.53094461
86	KIT	0.52731083
87	CSNK2A1	0.52719028
88	IKBKE	0.52010028
89	MAPK13	0.50818923
90	TYRO3	0.50433524
91	PRKACA	0.50253287
92	PAK1	0.49503139
93	RPS6KA4	0.49136299
94	SGK223	0.46901550
95	SGK494	0.46901550
96	LCK	0.46510292
97	FGFR2	0.45529084
98	PRKCE	0.45527443
99	PLK1	0.45008272
100	LYN	0.44382541

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.21067960
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.25732843
3	Parkinsons disease_Homo sapiens_hsa05012	3.65864912
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.62652696
5	Alzheimers disease_Homo sapiens_hsa05010	2.53158495
6	Sulfur relay system_Homo sapiens_hsa04122	2.52890289
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.52149244
8	Huntingtons disease_Homo sapiens_hsa05016	2.51860122
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34011164
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14842809
11	RNA polymerase_Homo sapiens_hsa03020	1.96238784
12	Proteasome_Homo sapiens_hsa03050	1.95430006
13	Phototransduction_Homo sapiens_hsa04744	1.80570007
14	Homologous recombination_Homo sapiens_hsa03440	1.75165744
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66509698
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.60359394
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55138463
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.41311951
19	One carbon pool by folate_Homo sapiens_hsa00670	1.37003101
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.35236078
21	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.33535806
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.29234015
23	Basal transcription factors_Homo sapiens_hsa03022	1.29190030
24	RNA degradation_Homo sapiens_hsa03018	1.27590995
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20870625
26	Nicotine addiction_Homo sapiens_hsa05033	1.20130701
27	Caffeine metabolism_Homo sapiens_hsa00232	1.19019869
28	Sulfur metabolism_Homo sapiens_hsa00920	1.16649158
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.15916204
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15839939
31	Retinol metabolism_Homo sapiens_hsa00830	1.15593185
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14385283
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.12751570
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11905165
35	Spliceosome_Homo sapiens_hsa03040	1.10241502
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07731188
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05230655
38	Asthma_Homo sapiens_hsa05310	1.05101887
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04822941
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04366347
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.03356059
42	Peroxisome_Homo sapiens_hsa04146	1.01944284
43	Butanoate metabolism_Homo sapiens_hsa00650	1.00924730
44	Taste transduction_Homo sapiens_hsa04742	0.99122418
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96276161
46	Folate biosynthesis_Homo sapiens_hsa00790	0.95269168
47	Mismatch repair_Homo sapiens_hsa03430	0.94051248
48	Allograft rejection_Homo sapiens_hsa05330	0.90146957
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.89204596
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87455071
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.87133649
52	Protein export_Homo sapiens_hsa03060	0.86636026
53	Purine metabolism_Homo sapiens_hsa00230	0.86630330
54	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85787205
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82438510
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80775509
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80161151
58	RNA transport_Homo sapiens_hsa03013	0.78515267
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.77378170
60	DNA replication_Homo sapiens_hsa03030	0.74839643
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74708608
62	Metabolic pathways_Homo sapiens_hsa01100	0.67186721
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65657373
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63363023
65	Renin-angiotensin system_Homo sapiens_hsa04614	0.58433761
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53998942
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.53626352
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.52094510
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.47352683
70	Morphine addiction_Homo sapiens_hsa05032	0.46082545
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45448627
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.43735348
73	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43256028
74	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42946401
75	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.41088560
76	Tyrosine metabolism_Homo sapiens_hsa00350	0.40706693
77	Olfactory transduction_Homo sapiens_hsa04740	0.39652314
78	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.39594926
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38993241
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38842324
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38527814
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37940194
83	Propanoate metabolism_Homo sapiens_hsa00640	0.37419084
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36708745
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36566212
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36260202
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34153121
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31354896
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.27868099
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.27324126
91	p53 signaling pathway_Homo sapiens_hsa04115	0.24717824
92	Serotonergic synapse_Homo sapiens_hsa04726	0.23923562
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.23452620
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.19999441
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.19819498
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.19386830
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19141923
98	Regulation of autophagy_Homo sapiens_hsa04140	0.17156786
99	Amphetamine addiction_Homo sapiens_hsa05031	0.16641366
100	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.16313923

RPS2P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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