RPS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.39087263
2* viral transcription (GO:0019083)7.85200809
3* translational termination (GO:0006415)7.57234805
4ribosomal small subunit biogenesis (GO:0042274)6.87172275
5* translational elongation (GO:0006414)6.60161504
6maturation of SSU-rRNA (GO:0030490)6.58950502
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.43646583
8* cotranslational protein targeting to membrane (GO:0006613)6.29942689
9* protein targeting to ER (GO:0045047)6.28737079
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.05230889
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.00199186
12* protein localization to endoplasmic reticulum (GO:0070972)5.88482535
13* viral life cycle (GO:0019058)5.87052089
14* cellular protein complex disassembly (GO:0043624)5.85281464
15* translational initiation (GO:0006413)5.79944630
16ribosomal large subunit biogenesis (GO:0042273)5.54331866
17* protein complex disassembly (GO:0043241)5.21988045
18* macromolecular complex disassembly (GO:0032984)4.88926879
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64509594
20* nuclear-transcribed mRNA catabolic process (GO:0000956)4.51725934
21ribonucleoprotein complex biogenesis (GO:0022613)4.44940037
22formation of translation preinitiation complex (GO:0001731)4.39560238
23* mRNA catabolic process (GO:0006402)4.30378431
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21318356
25ATP synthesis coupled proton transport (GO:0015986)4.21318356
26* translation (GO:0006412)4.13144324
27* protein targeting to membrane (GO:0006612)4.13026151
28DNA strand elongation involved in DNA replication (GO:0006271)4.12310421
29* RNA catabolic process (GO:0006401)4.09175604
30DNA deamination (GO:0045006)4.05045506
31DNA unwinding involved in DNA replication (GO:0006268)3.93821467
32telomere maintenance via semi-conservative replication (GO:0032201)3.93634804
33DNA strand elongation (GO:0022616)3.93299073
34rRNA processing (GO:0006364)3.68418496
35DNA replication initiation (GO:0006270)3.63155075
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.61855727
37rRNA metabolic process (GO:0016072)3.55521715
38telomere maintenance via recombination (GO:0000722)3.45261622
39establishment of viral latency (GO:0019043)3.28860310
40nucleobase biosynthetic process (GO:0046112)3.27909553
41mitotic recombination (GO:0006312)3.27335043
42regulation of mitochondrial translation (GO:0070129)3.26895346
43cellular component biogenesis (GO:0044085)3.25281424
44regulation of translational fidelity (GO:0006450)3.25254630
45ribosome biogenesis (GO:0042254)3.16845856
46rRNA modification (GO:0000154)3.14831885
47ncRNA 3-end processing (GO:0043628)3.13036067
48inner mitochondrial membrane organization (GO:0007007)3.12011469
49telomere maintenance via telomere lengthening (GO:0010833)3.11651220
50spliceosomal snRNP assembly (GO:0000387)3.07963818
51oxidative phosphorylation (GO:0006119)3.07502234
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.07208232
53IMP biosynthetic process (GO:0006188)3.06154650
54protein localization to kinetochore (GO:0034501)3.01044571
55DNA replication checkpoint (GO:0000076)3.00524871
56DNA ligation (GO:0006266)2.93998810
57negative regulation of RNA splicing (GO:0033119)2.93113697
58pseudouridine synthesis (GO:0001522)2.90895669
59chaperone-mediated protein transport (GO:0072321)2.90890629
60purine nucleobase biosynthetic process (GO:0009113)2.89921128
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89871004
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89741364
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89741364
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89741364
65base-excision repair (GO:0006284)2.88912280
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88423495
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.88423495
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88300734
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88300734
70respiratory electron transport chain (GO:0022904)2.88228951
71CENP-A containing nucleosome assembly (GO:0034080)2.86529557
72DNA replication-dependent nucleosome organization (GO:0034723)2.86159521
73DNA replication-dependent nucleosome assembly (GO:0006335)2.86159521
74folic acid-containing compound biosynthetic process (GO:0009396)2.84517641
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84425540
76chromatin remodeling at centromere (GO:0031055)2.83323339
77electron transport chain (GO:0022900)2.82026157
78signal transduction involved in cell cycle checkpoint (GO:0072395)2.81129933
79IMP metabolic process (GO:0046040)2.79689253
80spliceosomal complex assembly (GO:0000245)2.77349912
81* establishment of protein localization to membrane (GO:0090150)2.76569412
82establishment of integrated proviral latency (GO:0075713)2.75626553
83protein targeting to mitochondrion (GO:0006626)2.75305279
84DNA topological change (GO:0006265)2.74944146
85ribosome assembly (GO:0042255)2.73740148
86mitotic nuclear envelope disassembly (GO:0007077)2.72214923
87transcription-coupled nucleotide-excision repair (GO:0006283)2.71706134
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69746755
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69007940
90DNA replication-independent nucleosome assembly (GO:0006336)2.68772303
91DNA replication-independent nucleosome organization (GO:0034724)2.68772303
92ncRNA processing (GO:0034470)2.68386783
93GMP metabolic process (GO:0046037)2.68016837
94guanosine-containing compound biosynthetic process (GO:1901070)2.67991641
95ribonucleoprotein complex subunit organization (GO:0071826)2.66513437
96viral mRNA export from host cell nucleus (GO:0046784)2.65695183
97* establishment of protein localization to organelle (GO:0072594)2.64148804
98pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.63664158
99mRNA splicing, via spliceosome (GO:0000398)2.61600119
100RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61600119
101RNA splicing, via transesterification reactions (GO:0000375)2.60708758
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.59968227
103termination of RNA polymerase III transcription (GO:0006386)2.59968227
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58340798
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.56261034
106protein localization to chromosome, centromeric region (GO:0071459)2.56106188
107* protein targeting (GO:0006605)2.54208671
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54059285
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52644201
110termination of RNA polymerase II transcription (GO:0006369)2.52385290
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51882102
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51882102
113ribonucleoprotein complex assembly (GO:0022618)2.51776186
114negative regulation of ligase activity (GO:0051352)2.51342135
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51342135
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51060496
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51016192
118telomere organization (GO:0032200)2.50854305
119telomere maintenance (GO:0000723)2.50517722
120ncRNA metabolic process (GO:0034660)2.50218364
121* gene expression (GO:0010467)2.49951769
122histone mRNA metabolic process (GO:0008334)2.49242588
123mitotic metaphase plate congression (GO:0007080)2.48577983
124DNA duplex unwinding (GO:0032508)2.48450654
125nuclear envelope disassembly (GO:0051081)2.47561596
126membrane disassembly (GO:0030397)2.47561596
127proteasome assembly (GO:0043248)2.47238130
128DNA geometric change (GO:0032392)2.46325390
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45655296
130DNA-templated transcription, termination (GO:0006353)2.42899274
131kinetochore organization (GO:0051383)2.41757355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.23264012
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.37398979
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86961985
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15536256
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.99316125
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98014691
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.92470160
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.89188876
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.84885498
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.75528954
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74104655
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68260986
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61745245
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61178974
15XRN2_22483619_ChIP-Seq_HELA_Human2.52940963
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52011568
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47786213
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42379514
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38215347
20VDR_23849224_ChIP-Seq_CD4+_Human2.28165442
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18015901
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17995282
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15081390
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12740535
25MYC_22102868_ChIP-Seq_BL_Human2.08000829
26FOXP3_21729870_ChIP-Seq_TREG_Human2.04277634
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01660747
28* TTF2_22483619_ChIP-Seq_HELA_Human1.95857524
29DCP1A_22483619_ChIP-Seq_HELA_Human1.89985070
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89025527
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.77691730
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75673846
33CIITA_25753668_ChIP-Seq_RAJI_Human1.75595368
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73170025
35ELK1_19687146_ChIP-ChIP_HELA_Human1.72651245
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70243842
37* GABP_19822575_ChIP-Seq_HepG2_Human1.67708709
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65051725
39* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63761809
40VDR_21846776_ChIP-Seq_THP-1_Human1.61400754
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58218484
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.57624527
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56450130
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53481084
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52070072
46* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51502030
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51291539
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46984980
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45733812
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43252524
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42879597
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42494066
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40679943
54AR_21909140_ChIP-Seq_LNCAP_Human1.38661298
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36285051
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35586399
57* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35455367
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.34850725
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34258962
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.32253992
61KDM5A_27292631_Chip-Seq_BREAST_Human1.31072161
62* SPI1_23547873_ChIP-Seq_NB4_Human1.29008430
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.28073405
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27563431
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27212788
66* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26528421
67SCL_19346495_ChIP-Seq_HPC-7_Human1.22880856
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22622863
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21171581
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19146570
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17101954
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15665692
73ZNF263_19887448_ChIP-Seq_K562_Human1.11974944
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10550785
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09717517
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09462198
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07967123
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.06968686
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06861039
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06017731
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05004227
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04529626
83TFEB_21752829_ChIP-Seq_HELA_Human1.04097751
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04093991
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.04011412
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03880645
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.03756827
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03024703
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02675398
90MYC_18940864_ChIP-ChIP_HL60_Human1.01916009
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01204961
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.01140324
93MAF_26560356_Chip-Seq_TH1_Human1.01002835
94UTX_26944678_Chip-Seq_JUKART_Human1.00095128
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99988208
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98932324
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98763420
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98378609
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98184841
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96988648
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96341549
102CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96227076
103MYB_26560356_Chip-Seq_TH2_Human0.95800222
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95483348
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95279150
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94188820
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93967511
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92049892
109MAF_26560356_Chip-Seq_TH2_Human0.91368141
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90923265
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90666172
112MYB_26560356_Chip-Seq_TH1_Human0.90374131
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90020723
114* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89745760
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88344685
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83194875
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81114103
118* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80848776
119NANOG_21062744_ChIP-ChIP_HESCs_Human0.79978753
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79326680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.20854566
2MP0004957_abnormal_blastocyst_morpholog3.56033153
3MP0010094_abnormal_chromosome_stability3.42771079
4MP0003077_abnormal_cell_cycle3.14798426
5MP0003111_abnormal_nucleus_morphology3.13069707
6MP0002396_abnormal_hematopoietic_system3.12152714
7MP0008057_abnormal_DNA_replication2.77135025
8MP0009379_abnormal_foot_pigmentation2.76181980
9MP0008058_abnormal_DNA_repair2.52921036
10MP0008007_abnormal_cellular_replicative2.38936805
11MP0003763_abnormal_thymus_physiology2.34025826
12MP0000372_irregular_coat_pigmentation2.19414772
13MP0000490_abnormal_crypts_of2.15475774
14MP0003806_abnormal_nucleotide_metabolis2.14376348
15MP0004808_abnormal_hematopoietic_stem2.12538715
16MP0010352_gastrointestinal_tract_polyps1.99102369
17MP0009333_abnormal_splenocyte_physiolog1.96760916
18MP0008932_abnormal_embryonic_tissue1.88580755
19MP0006292_abnormal_olfactory_placode1.83600326
20MP0001835_abnormal_antigen_presentation1.82986191
21MP0002398_abnormal_bone_marrow1.77691517
22MP0001545_abnormal_hematopoietic_system1.74000662
23MP0005397_hematopoietic_system_phenotyp1.74000662
24MP0000685_abnormal_immune_system1.70396207
25MP0003786_premature_aging1.70379821
26MP0000350_abnormal_cell_proliferation1.70006236
27MP0000566_synostosis1.67084383
28MP0001730_embryonic_growth_arrest1.65771697
29MP0000703_abnormal_thymus_morphology1.62187546
30MP0006054_spinal_hemorrhage1.59620297
31MP0002722_abnormal_immune_system1.59466336
32MP0005671_abnormal_response_to1.56388636
33MP0006035_abnormal_mitochondrial_morpho1.55962740
34MP0000689_abnormal_spleen_morphology1.52765798
35MP0001800_abnormal_humoral_immune1.51598017
36MP0002166_altered_tumor_susceptibility1.49267387
37MP0003123_paternal_imprinting1.48935875
38MP0002019_abnormal_tumor_incidence1.48860092
39MP0002429_abnormal_blood_cell1.39991081
40MP0002420_abnormal_adaptive_immunity1.38744559
41MP0000716_abnormal_immune_system1.37735790
42MP0005174_abnormal_tail_pigmentation1.36957821
43MP0001819_abnormal_immune_cell1.36087581
44MP0006036_abnormal_mitochondrial_physio1.35932582
45MP0009697_abnormal_copulation1.35879155
46MP0000465_gastrointestinal_hemorrhage1.35248976
47MP0000313_abnormal_cell_death1.35151412
48MP0002452_abnormal_antigen_presenting1.33639701
49MP0010307_abnormal_tumor_latency1.31858660
50MP0001346_abnormal_lacrimal_gland1.31475693
51MP0003567_abnormal_fetal_cardiomyocyte1.30287064
52MP0003136_yellow_coat_color1.27714159
53MP0005075_abnormal_melanosome_morpholog1.27009691
54MP0002132_abnormal_respiratory_system1.25280099
55MP0002723_abnormal_immune_serum1.24575586
56MP0001697_abnormal_embryo_size1.24363398
57MP0009785_altered_susceptibility_to1.24232497
58MP0002080_prenatal_lethality1.23594951
59MP0002006_tumorigenesis1.23594486
60MP0010155_abnormal_intestine_physiology1.20720663
61MP0002405_respiratory_system_inflammati1.18010867
62MP0005025_abnormal_response_to1.17216041
63MP0009278_abnormal_bone_marrow1.16808585
64MP0001873_stomach_inflammation1.16228134
65MP0009672_abnormal_birth_weight1.15652358
66MP0005380_embryogenesis_phenotype1.14867928
67MP0001672_abnormal_embryogenesis/_devel1.14867928
68MP0002163_abnormal_gland_morphology1.14783452
69MP0001853_heart_inflammation1.14610090
70MP0000858_altered_metastatic_potential1.13862526
71MP0003866_abnormal_defecation1.13751515
72MP0002095_abnormal_skin_pigmentation1.12938131
73MP0005000_abnormal_immune_tolerance1.12407308
74MP0005408_hypopigmentation1.10010630
75MP0003315_abnormal_perineum_morphology1.07621617
76MP0003984_embryonic_growth_retardation1.05664078
77MP0002086_abnormal_extraembryonic_tissu1.04392933
78MP0002088_abnormal_embryonic_growth/wei1.03597488
79MP0002085_abnormal_embryonic_tissue1.03501241
80MP0003436_decreased_susceptibility_to1.01132853
81MP0002084_abnormal_developmental_patter1.00018141
82MP0004197_abnormal_fetal_growth/weight/0.99905503
83MP0002148_abnormal_hypersensitivity_rea0.96046199
84MP0000537_abnormal_urethra_morphology0.94849306
85MP0001286_abnormal_eye_development0.94144452
86MP0002796_impaired_skin_barrier0.92836397
87MP0001881_abnormal_mammary_gland0.91620471
88MP0004147_increased_porphyrin_level0.91577739
89MP0005464_abnormal_platelet_physiology0.90487273
90MP0001929_abnormal_gametogenesis0.90077792
91MP0000477_abnormal_intestine_morphology0.89526649
92MP0001293_anophthalmia0.89180472
93MP0005023_abnormal_wound_healing0.87418130
94MP0005387_immune_system_phenotype0.86167797
95MP0001790_abnormal_immune_system0.86167797
96MP0004264_abnormal_extraembryonic_tissu0.85684318
97MP0000653_abnormal_sex_gland0.84430952
98MP0002697_abnormal_eye_size0.83456315
99MP0001764_abnormal_homeostasis0.80221358
100MP0010030_abnormal_orbit_morphology0.79058394
101MP0002938_white_spotting0.78196377
102MP0003943_abnormal_hepatobiliary_system0.77496906
103MP0005501_abnormal_skin_physiology0.77305935
104MP0003941_abnormal_skin_development0.75189708
105MP0003283_abnormal_digestive_organ0.73668951
106MP0003186_abnormal_redox_activity0.73148564
107MP0002098_abnormal_vibrissa_morphology0.72608385
108MP0002160_abnormal_reproductive_system0.71613617
109MP0003937_abnormal_limbs/digits/tail_de0.70568692
110MP0004947_skin_inflammation0.70323876
111MP0005377_hearing/vestibular/ear_phenot0.69773843
112MP0003878_abnormal_ear_physiology0.69773843
113MP0001845_abnormal_inflammatory_respons0.68916279
114MP0008877_abnormal_DNA_methylation0.68059316
115MP0002210_abnormal_sex_determination0.67116157
116MP0000358_abnormal_cell_content/0.66795941
117MP0004185_abnormal_adipocyte_glucose0.66205691
118MP0005220_abnormal_exocrine_pancreas0.66042142
119MP0004381_abnormal_hair_follicle0.65780240
120MP0002419_abnormal_innate_immunity0.65777363
121MP0001119_abnormal_female_reproductive0.64496947
122MP0008789_abnormal_olfactory_epithelium0.63981416
123MP0003566_abnormal_cell_adhesion0.63036123
124MP0002111_abnormal_tail_morphology0.62348974
125MP0001145_abnormal_male_reproductive0.61961906
126MP0003890_abnormal_embryonic-extraembry0.61687214
127MP0003448_altered_tumor_morphology0.61672768
128MP0003718_maternal_effect0.61579675
129MP0000462_abnormal_digestive_system0.59668458
130MP0003121_genomic_imprinting0.59000791
131MP0001216_abnormal_epidermal_layer0.58656565
132MP0006072_abnormal_retinal_apoptosis0.58049340
133MP0002277_abnormal_respiratory_mucosa0.56871447
134MP0009703_decreased_birth_body0.56866449
135MP0003938_abnormal_ear_development0.56130263
136MP0003699_abnormal_female_reproductive0.56000511
137MP0001915_intracranial_hemorrhage0.55581362
138MP0002009_preneoplasia0.55417920
139MP0008995_early_reproductive_senescence0.55327246

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.68780552
2Reticulocytopenia (HP:0001896)7.23519397
3Abnormal number of erythroid precursors (HP:0012131)7.05388877
4Macrocytic anemia (HP:0001972)5.06920336
5Pallor (HP:0000980)4.88360547
6Thrombocytosis (HP:0001894)4.40365017
7Colon cancer (HP:0003003)3.88299344
8Aplastic anemia (HP:0001915)3.77911006
9Microvesicular hepatic steatosis (HP:0001414)3.66823613
10Acute necrotizing encephalopathy (HP:0006965)3.59970933
11Mitochondrial inheritance (HP:0001427)3.57648571
12Abnormal mitochondria in muscle tissue (HP:0008316)3.56118052
13Lipid accumulation in hepatocytes (HP:0006561)3.43357287
14Hepatocellular necrosis (HP:0001404)3.43290150
15Acute encephalopathy (HP:0006846)3.36373200
1611 pairs of ribs (HP:0000878)3.34015178
17Increased CSF lactate (HP:0002490)3.29035530
18IgM deficiency (HP:0002850)3.23083151
19Hepatic necrosis (HP:0002605)3.13333976
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00190991
21Oral leukoplakia (HP:0002745)2.96992646
22Birth length less than 3rd percentile (HP:0003561)2.91931029
23Increased intramyocellular lipid droplets (HP:0012240)2.91479776
24Progressive macrocephaly (HP:0004481)2.75077402
25Absent thumb (HP:0009777)2.74184385
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72812890
27Respiratory difficulties (HP:0002880)2.72520880
28Selective tooth agenesis (HP:0001592)2.67521515
29Increased serum lactate (HP:0002151)2.61539847
30Renal Fanconi syndrome (HP:0001994)2.59277463
31Cerebral edema (HP:0002181)2.59028509
32Myelodysplasia (HP:0002863)2.56842921
33Chronic otitis media (HP:0000389)2.56658512
34Abnormality of reticulocytes (HP:0004312)2.49920096
35Increased muscle lipid content (HP:0009058)2.43597576
36Progressive muscle weakness (HP:0003323)2.40497532
37Basal cell carcinoma (HP:0002671)2.39107160
38Rough bone trabeculation (HP:0100670)2.39017534
39Elevated erythrocyte sedimentation rate (HP:0003565)2.37716993
40Lactic acidosis (HP:0003128)2.37707327
41Recurrent bronchitis (HP:0002837)2.35494958
42Exercise intolerance (HP:0003546)2.33825237
43Asplenia (HP:0001746)2.33812296
44Lymphoma (HP:0002665)2.32699419
45Trismus (HP:0000211)2.27404155
46Microretrognathia (HP:0000308)2.27281033
47Multiple enchondromatosis (HP:0005701)2.26391813
48Petechiae (HP:0000967)2.25235582
49Agnosia (HP:0010524)2.25009162
50Depressed nasal ridge (HP:0000457)2.23265143
51Amaurosis fugax (HP:0100576)2.22690990
52Breast hypoplasia (HP:0003187)2.22559710
53Abnormality of methionine metabolism (HP:0010901)2.20634296
54Abnormality of glycolysis (HP:0004366)2.19163614
55Neoplasm of the pancreas (HP:0002894)2.17601825
56Carpal bone hypoplasia (HP:0001498)2.17190367
57Medulloblastoma (HP:0002885)2.17164549
58Poikiloderma (HP:0001029)2.16692037
59Abnormality of T cells (HP:0002843)2.14566941
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.14090536
61Abnormal protein glycosylation (HP:0012346)2.13746761
62Abnormal glycosylation (HP:0012345)2.13746761
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13746761
64Abnormal protein N-linked glycosylation (HP:0012347)2.13746761
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.12441464
66Abnormality of the preputium (HP:0100587)2.10443781
67Stenosis of the external auditory canal (HP:0000402)2.09168650
68Premature graying of hair (HP:0002216)2.08788073
69Missing ribs (HP:0000921)2.08178682
70Abnormal hemoglobin (HP:0011902)2.08024413
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06543008
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06543008
73Patellar aplasia (HP:0006443)2.06509300
74Abnormality of T cell physiology (HP:0011840)2.06087652
75Pancytopenia (HP:0001876)2.04529600
76Reduced antithrombin III activity (HP:0001976)2.04482667
77Degeneration of anterior horn cells (HP:0002398)2.03425244
78Abnormality of the anterior horn cell (HP:0006802)2.03425244
79Chromsome breakage (HP:0040012)2.02006145
80Aplasia/Hypoplasia of the patella (HP:0006498)2.00894051
813-Methylglutaconic aciduria (HP:0003535)1.99582678
82Triphalangeal thumb (HP:0001199)1.97907065
83Cholecystitis (HP:0001082)1.95897829
84Abnormal gallbladder physiology (HP:0012438)1.95897829
85Bilateral microphthalmos (HP:0007633)1.95781042
86Ependymoma (HP:0002888)1.94981536
87Increased serum pyruvate (HP:0003542)1.94388122
88Testicular atrophy (HP:0000029)1.94058672
89Meckel diverticulum (HP:0002245)1.93607125
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93497314
91Cellular immunodeficiency (HP:0005374)1.93010318
92Thick lower lip vermilion (HP:0000179)1.92558008
93Panhypogammaglobulinemia (HP:0003139)1.92529174
94Abnormality of chromosome stability (HP:0003220)1.92242757
95IgG deficiency (HP:0004315)1.91679575
96Bone marrow hypocellularity (HP:0005528)1.91402450
97Abnormal number of incisors (HP:0011064)1.91119689
98Recurrent viral infections (HP:0004429)1.90961365
99Respiratory failure (HP:0002878)1.90944251
100T lymphocytopenia (HP:0005403)1.89392583
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.87843788
102Cleft eyelid (HP:0000625)1.87798100
103Glossoptosis (HP:0000162)1.87686735
104Migraine (HP:0002076)1.86248957
105Hypoplasia of the radius (HP:0002984)1.85516423
106Atresia of the external auditory canal (HP:0000413)1.85305375
107Abnormality of the ileum (HP:0001549)1.85294572
108Squamous cell carcinoma (HP:0002860)1.85210257
109Abnormality of B cell number (HP:0010975)1.83390247
110B lymphocytopenia (HP:0010976)1.83390247
111Type I transferrin isoform profile (HP:0003642)1.81890443
112Duplication of thumb phalanx (HP:0009942)1.80385575
113Congenital, generalized hypertrichosis (HP:0004540)1.79439041
114Horseshoe kidney (HP:0000085)1.77714899
115Abnormality of cells of the lymphoid lineage (HP:0012140)1.77090865
116Abnormality of T cell number (HP:0011839)1.73328523
117Tracheoesophageal fistula (HP:0002575)1.71985188
118Abnormality of homocysteine metabolism (HP:0010919)1.71453299
119Homocystinuria (HP:0002156)1.71453299
120Lymphopenia (HP:0001888)1.70880451
121Abnormality of the parietal bone (HP:0002696)1.70861664
122Lethargy (HP:0001254)1.70564943
123Abnormality of DNA repair (HP:0003254)1.70545051
124Premature ovarian failure (HP:0008209)1.70421622
125Sparse eyelashes (HP:0000653)1.70026893
126Aplasia/Hypoplasia of the thymus (HP:0010515)1.69720469
127Optic nerve coloboma (HP:0000588)1.69463811
128Facial cleft (HP:0002006)1.69194678
129Exertional dyspnea (HP:0002875)1.69109433
130Increased hepatocellular lipid droplets (HP:0006565)1.68658668
131Rhabdomyosarcoma (HP:0002859)1.68637949
132Proximal placement of thumb (HP:0009623)1.68481134
133Cerebral hypomyelination (HP:0006808)1.68314665
134Muscle fiber atrophy (HP:0100295)1.68194644
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67968351
136Optic disc pallor (HP:0000543)1.65854316
137Abnormality of small intestinal villus morphology (HP:0011472)1.65380752
138Villous atrophy (HP:0011473)1.65380752
139Cellulitis (HP:0100658)1.65078318
140Leukodystrophy (HP:0002415)1.64927724
141Partial duplication of thumb phalanx (HP:0009944)1.64702070
142Abnormal trabecular bone morphology (HP:0100671)1.64650117
143Duplicated collecting system (HP:0000081)1.64535224
144Megaloblastic anemia (HP:0001889)1.64244206
145Abnormal lung lobation (HP:0002101)1.64237073
146Acute lymphatic leukemia (HP:0006721)1.62996346
147Abnormality of the duodenum (HP:0002246)1.62742048
148Neoplasm of the colon (HP:0100273)1.61797692
149Duodenal stenosis (HP:0100867)1.61731590
150Small intestinal stenosis (HP:0012848)1.61731590
151Abnormality of the labia minora (HP:0012880)1.60225946
152Deviation of the thumb (HP:0009603)1.58517160
153Entropion (HP:0000621)1.58269186
154Prolonged bleeding time (HP:0003010)1.56981518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.03055014
2NME23.98309807
3WEE13.40262593
4BUB13.22777719
5EEF2K3.20068611
6TLK12.97811489
7PBK2.83667958
8CDC72.50789047
9RPS6KB22.50370068
10MAP4K12.38401678
11PASK2.31778250
12TAF12.26966613
13SMG12.26346925
14TGFBR12.24789271
15SRPK12.17182254
16EIF2AK12.08687836
17STK162.05269123
18TSSK61.97910053
19NEK21.97446981
20LRRK21.94636427
21FLT31.91060964
22VRK11.78833083
23DYRK31.73549786
24MAP3K101.61053753
25ACVR1B1.60339624
26MKNK11.59885503
27PIM21.59030742
28PKN21.55788547
29TESK21.49985370
30RPS6KA41.47830194
31BRSK21.45505226
32BTK1.42793147
33CDK71.40195892
34AURKB1.38378476
35NUAK11.34071215
36STK101.32448480
37BCKDK1.31982198
38ATR1.30890302
39TRIB31.26486338
40EIF2AK31.22804349
41KIT1.21754360
42TEC1.20668912
43PIM11.18659957
44ZAP701.18480858
45MST41.18180958
46PLK11.16509466
47CDK41.11369778
48MAP3K81.09989468
49SCYL21.09313005
50TTK1.06528412
51CDK191.04968186
52JAK31.02962625
53PAK41.01930058
54KDR1.00248402
55MAP2K30.98833224
56MKNK20.95949285
57ILK0.95646826
58CSF1R0.90832898
59BLK0.89729831
60EPHA20.89115765
61MAPKAPK30.88811164
62STK40.86340926
63GRK60.81916258
64TXK0.80580760
65NEK10.79925738
66DAPK10.78544375
67PLK40.76669183
68TYK20.75942585
69EIF2AK20.73349555
70CHEK10.73286861
71AURKA0.72794533
72SYK0.72045133
73CLK10.71507166
74CSNK2A20.70825334
75CHEK20.70816514
76RPS6KA50.70206998
77CDK80.68833912
78NLK0.64851864
79PDK20.61451438
80LCK0.60348507
81PLK30.58872188
82ZAK0.58346505
83CSNK2A10.57311526
84ITK0.56937443
85TBK10.56460109
86MAP3K30.55944336
87BRSK10.54220948
88LYN0.53631363
89CDK90.51977605
90IKBKE0.51410768
91MAPKAPK50.51310043
92PAK10.50411513
93ATM0.49895112
94* CDK20.48481382
95DYRK20.46370918
96CDK60.45850827
97PAK20.45680546
98CCNB10.45680376
99MAP3K110.44390551
100IRAK40.43768106
101TGFBR20.43627186
102ALK0.43231612
103RPS6KA60.41100335
104MAP2K20.40355302
105PRKCI0.40277501
106RPS6KL10.39832351
107RPS6KC10.39832351
108MUSK0.39299625
109* CDK10.38326840
110NME10.35608548
111PRPF4B0.34706618
112CDK120.34048896
113DAPK30.33253788
114MATK0.31984200
115MAPKAPK20.31024748
116TESK10.30959699
117AKT20.30760635
118MAP4K20.29760815
119BRAF0.28195626
120SIK10.28036862
121FGFR20.26709312
122MAP3K120.24271607
123PTK60.24138095
124FGFR10.23245634
125MELK0.22097229
126CSNK1E0.21622786

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.12158958
2DNA replication_Homo sapiens_hsa030304.38693726
3Mismatch repair_Homo sapiens_hsa034303.68748913
4Spliceosome_Homo sapiens_hsa030403.09968507
5RNA polymerase_Homo sapiens_hsa030202.99404093
6Proteasome_Homo sapiens_hsa030502.98134449
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86279886
8Base excision repair_Homo sapiens_hsa034102.71321688
9Homologous recombination_Homo sapiens_hsa034402.61194388
10Nucleotide excision repair_Homo sapiens_hsa034202.54441732
11RNA transport_Homo sapiens_hsa030132.44258782
12Pyrimidine metabolism_Homo sapiens_hsa002402.27662700
13One carbon pool by folate_Homo sapiens_hsa006702.03310377
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00986954
15Cell cycle_Homo sapiens_hsa041101.98673995
16Non-homologous end-joining_Homo sapiens_hsa034501.93761934
17Fanconi anemia pathway_Homo sapiens_hsa034601.71770592
18RNA degradation_Homo sapiens_hsa030181.63477269
19Primary immunodeficiency_Homo sapiens_hsa053401.62117040
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60820529
21Alzheimers disease_Homo sapiens_hsa050101.45396910
22Basal transcription factors_Homo sapiens_hsa030221.45011772
23p53 signaling pathway_Homo sapiens_hsa041151.36497299
24Systemic lupus erythematosus_Homo sapiens_hsa053221.35932420
25Antigen processing and presentation_Homo sapiens_hsa046121.34288130
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29774435
27Protein export_Homo sapiens_hsa030601.28190756
28mRNA surveillance pathway_Homo sapiens_hsa030151.25342481
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24260661
30Carbon metabolism_Homo sapiens_hsa012001.17399230
31Epstein-Barr virus infection_Homo sapiens_hsa051691.14585033
32Herpes simplex infection_Homo sapiens_hsa051681.14471346
33Purine metabolism_Homo sapiens_hsa002301.11806958
34Pyruvate metabolism_Homo sapiens_hsa006200.99974896
35Viral carcinogenesis_Homo sapiens_hsa052030.95332988
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92827026
37Fatty acid elongation_Homo sapiens_hsa000620.90674159
38Sulfur relay system_Homo sapiens_hsa041220.86732477
39Measles_Homo sapiens_hsa051620.84822439
40Pentose phosphate pathway_Homo sapiens_hsa000300.83124423
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81855058
42Hematopoietic cell lineage_Homo sapiens_hsa046400.81650199
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.81081581
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.81067908
45HTLV-I infection_Homo sapiens_hsa051660.80336981
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77978646
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76706710
48Legionellosis_Homo sapiens_hsa051340.73442319
49Folate biosynthesis_Homo sapiens_hsa007900.70096224
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69550720
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.67767708
52Fructose and mannose metabolism_Homo sapiens_hsa000510.67070894
53Parkinsons disease_Homo sapiens_hsa050120.66710900
54Cardiac muscle contraction_Homo sapiens_hsa042600.66606593
55Small cell lung cancer_Homo sapiens_hsa052220.66293497
56Thyroid cancer_Homo sapiens_hsa052160.64978611
57Propanoate metabolism_Homo sapiens_hsa006400.62887169
58Huntingtons disease_Homo sapiens_hsa050160.61448457
59Apoptosis_Homo sapiens_hsa042100.60576416
60B cell receptor signaling pathway_Homo sapiens_hsa046620.59995249
61Metabolic pathways_Homo sapiens_hsa011000.59957764
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59360185
63N-Glycan biosynthesis_Homo sapiens_hsa005100.59341555
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57562633
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57414673
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56431382
67Acute myeloid leukemia_Homo sapiens_hsa052210.54650203
68Shigellosis_Homo sapiens_hsa051310.54493017
69Hepatitis B_Homo sapiens_hsa051610.53936504
70Leishmaniasis_Homo sapiens_hsa051400.51950247
71Allograft rejection_Homo sapiens_hsa053300.51430405
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.51360241
73Chronic myeloid leukemia_Homo sapiens_hsa052200.50730434
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49972957
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49659365
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49027391
77Notch signaling pathway_Homo sapiens_hsa043300.48713734
78Alcoholism_Homo sapiens_hsa050340.47667920
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.47117442
80T cell receptor signaling pathway_Homo sapiens_hsa046600.45985613
81MicroRNAs in cancer_Homo sapiens_hsa052060.45984278
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45677601
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44536015
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44372609
85Influenza A_Homo sapiens_hsa051640.41783765
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41339321
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41327849
88Oxidative phosphorylation_Homo sapiens_hsa001900.41230148
89Vitamin digestion and absorption_Homo sapiens_hsa049770.41201270
90Selenocompound metabolism_Homo sapiens_hsa004500.38431305
91Glutathione metabolism_Homo sapiens_hsa004800.38265134
92Galactose metabolism_Homo sapiens_hsa000520.37879390
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.36454353
94Colorectal cancer_Homo sapiens_hsa052100.36226441
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35687796
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34028701
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33635063
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.32077897
99Asthma_Homo sapiens_hsa053100.31677701
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30778507
101Basal cell carcinoma_Homo sapiens_hsa052170.30752399
102Toxoplasmosis_Homo sapiens_hsa051450.30626466
103Pathways in cancer_Homo sapiens_hsa052000.30330061
104Viral myocarditis_Homo sapiens_hsa054160.30139959
105Oocyte meiosis_Homo sapiens_hsa041140.30026591
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.29782563
107Biosynthesis of amino acids_Homo sapiens_hsa012300.29203320
108HIF-1 signaling pathway_Homo sapiens_hsa040660.28698852
109Other glycan degradation_Homo sapiens_hsa005110.28341165
110Graft-versus-host disease_Homo sapiens_hsa053320.28017446
111Bladder cancer_Homo sapiens_hsa052190.27566836
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27101309
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.26940931
114Peroxisome_Homo sapiens_hsa041460.25100979
115Steroid biosynthesis_Homo sapiens_hsa001000.23885055
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23833992
117TGF-beta signaling pathway_Homo sapiens_hsa043500.23718312
118Non-small cell lung cancer_Homo sapiens_hsa052230.23473084
119Platelet activation_Homo sapiens_hsa046110.23195874
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22775430
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21662415
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21043068
123Osteoclast differentiation_Homo sapiens_hsa043800.19445881
124Vitamin B6 metabolism_Homo sapiens_hsa007500.17448544
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14879481
126Sulfur metabolism_Homo sapiens_hsa009200.13661041
127Lysine degradation_Homo sapiens_hsa003100.12440884
128Wnt signaling pathway_Homo sapiens_hsa043100.11789935
129Hedgehog signaling pathway_Homo sapiens_hsa043400.11488553
130Butanoate metabolism_Homo sapiens_hsa006500.05426172
131Tyrosine metabolism_Homo sapiens_hsa003500.04855582
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.03578017
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02871824
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02595798
135Prostate cancer_Homo sapiens_hsa052150.01121088

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