RPS3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.75999903
2* translational elongation (GO:0006414)9.61149315
3* cotranslational protein targeting to membrane (GO:0006613)9.59251704
4* protein targeting to ER (GO:0045047)9.47877151
5* establishment of protein localization to endoplasmic reticulum (GO:0072599)9.09235503
6* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.92815072
7ribosomal small subunit biogenesis (GO:0042274)8.90127686
8ribosomal large subunit biogenesis (GO:0042273)8.89069661
9* protein localization to endoplasmic reticulum (GO:0070972)8.86678800
10* cellular protein complex disassembly (GO:0043624)8.76190847
11* viral life cycle (GO:0019058)8.62815297
12* translational initiation (GO:0006413)8.14579396
13* protein complex disassembly (GO:0043241)7.57961454
14maturation of SSU-rRNA (GO:0030490)7.42444829
15* macromolecular complex disassembly (GO:0032984)7.17969630
16* protein targeting to membrane (GO:0006612)6.40969355
17* nuclear-transcribed mRNA catabolic process (GO:0000956)6.25659610
18* mRNA catabolic process (GO:0006402)5.95374798
19* translation (GO:0006412)5.53918677
20* RNA catabolic process (GO:0006401)5.44118256
21ribonucleoprotein complex biogenesis (GO:0022613)5.16135654
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.05801734
23formation of translation preinitiation complex (GO:0001731)4.73046427
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63935640
25ATP synthesis coupled proton transport (GO:0015986)4.63935640
26* establishment of protein localization to membrane (GO:0090150)4.27062674
27cellular component biogenesis (GO:0044085)4.19505556
28* protein targeting (GO:0006605)3.82944252
29* establishment of protein localization to organelle (GO:0072594)3.77829036
30rRNA processing (GO:0006364)3.44268247
31* protein localization to membrane (GO:0072657)3.41012958
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.40064878
33rRNA metabolic process (GO:0016072)3.31565981
34chromatin remodeling at centromere (GO:0031055)3.27001945
35CENP-A containing nucleosome assembly (GO:0034080)3.26265092
36* protein localization to organelle (GO:0033365)2.85083796
37ribonucleoprotein complex assembly (GO:0022618)2.81627889
38spliceosomal complex assembly (GO:0000245)2.78895364
39regulation of histone H3-K9 methylation (GO:0051570)2.77157036
40mitochondrial respiratory chain complex I assembly (GO:0032981)2.74156839
41NADH dehydrogenase complex assembly (GO:0010257)2.74156839
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74156839
43oxidative phosphorylation (GO:0006119)2.73745549
44DNA topological change (GO:0006265)2.73647237
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73246063
46positive regulation of histone H3-K4 methylation (GO:0051571)2.68295563
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68165482
48respiratory electron transport chain (GO:0022904)2.67734866
49ribonucleoprotein complex subunit organization (GO:0071826)2.67636087
50inner mitochondrial membrane organization (GO:0007007)2.66538209
51protein complex biogenesis (GO:0070271)2.62214543
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61889321
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61889321
54DNA ligation (GO:0006266)2.61818374
55mitochondrial respiratory chain complex assembly (GO:0033108)2.61666448
56electron transport chain (GO:0022900)2.61542283
57DNA damage response, detection of DNA damage (GO:0042769)2.59902201
58* cellular component disassembly (GO:0022411)2.57170872
59purine nucleobase biosynthetic process (GO:0009113)2.57149726
60forebrain morphogenesis (GO:0048853)2.56739925
61protein neddylation (GO:0045116)2.54976746
62establishment of integrated proviral latency (GO:0075713)2.50508294
63chaperone-mediated protein transport (GO:0072321)2.50178450
64GTP biosynthetic process (GO:0006183)2.48653465
65viral mRNA export from host cell nucleus (GO:0046784)2.47723357
66ribosome biogenesis (GO:0042254)2.47489034
67DNA unwinding involved in DNA replication (GO:0006268)2.45645029
68DNA replication-independent nucleosome organization (GO:0034724)2.44790719
69DNA replication-independent nucleosome assembly (GO:0006336)2.44790719
70* gene expression (GO:0010467)2.44511281
71organelle disassembly (GO:1903008)2.43571626
72negative regulation of RNA splicing (GO:0033119)2.42006660
73telomere maintenance via semi-conservative replication (GO:0032201)2.40665178
74primitive streak formation (GO:0090009)2.40209715
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39806545
76UTP biosynthetic process (GO:0006228)2.38645001
77histone exchange (GO:0043486)2.38325825
78spliceosomal snRNP assembly (GO:0000387)2.37629336
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.35991281
80purine nucleoside triphosphate biosynthetic process (GO:0009145)2.35294336
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.35023085
82DNA strand elongation involved in DNA replication (GO:0006271)2.33048592
83UTP metabolic process (GO:0046051)2.32585139
84guanosine-containing compound biosynthetic process (GO:1901070)2.31875423
85centriole replication (GO:0007099)2.30846499
86ATP biosynthetic process (GO:0006754)2.30718755
87ncRNA processing (GO:0034470)2.30377303
88nucleobase biosynthetic process (GO:0046112)2.28935778
89negative regulation of translational initiation (GO:0045947)2.28278154
90pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.24030170
91spermatid nucleus differentiation (GO:0007289)2.23385857
92ribonucleoside triphosphate biosynthetic process (GO:0009201)2.23197288
93mitotic recombination (GO:0006312)2.22757998
94telomere maintenance via recombination (GO:0000722)2.20132230
95aerobic respiration (GO:0009060)2.19787731
96DNA strand elongation (GO:0022616)2.18785994
97otic vesicle formation (GO:0030916)2.18318958
98* viral transcription (GO:0019083)12.0120882
99ribosomal small subunit assembly (GO:0000028)11.6439215
100* translational termination (GO:0006415)11.5329031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_18555785_ChIP-Seq_MESCs_Mouse5.10620389
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.75489419
3E2F7_22180533_ChIP-Seq_HELA_Human4.74447749
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.09023454
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.08878883
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.54473742
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.51317132
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48482325
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40210227
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15640144
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15626418
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09063627
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04159710
14* ETS1_20019798_ChIP-Seq_JURKAT_Human3.00450738
15ELK1_19687146_ChIP-ChIP_HELA_Human2.97472814
16* TTF2_22483619_ChIP-Seq_HELA_Human2.92127381
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82941262
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81606896
19* VDR_23849224_ChIP-Seq_CD4+_Human2.71661897
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69092711
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63040974
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58005155
23XRN2_22483619_ChIP-Seq_HELA_Human2.54049210
24FOXP3_21729870_ChIP-Seq_TREG_Human2.53683400
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48286204
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42743773
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.40831520
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29221713
29FUS_26573619_Chip-Seq_HEK293_Human2.26057131
30GATA1_22025678_ChIP-Seq_K562_Human2.17491662
31MYC_18940864_ChIP-ChIP_HL60_Human2.14110259
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91682277
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86495901
34EWS_26573619_Chip-Seq_HEK293_Human1.76801751
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71958167
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68943337
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66266222
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.66118857
39DCP1A_22483619_ChIP-Seq_HELA_Human1.62521449
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56463020
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55322756
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55018843
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54032161
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51777536
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51367547
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51259714
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46613900
48VDR_22108803_ChIP-Seq_LS180_Human1.45161007
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41458297
50IRF1_19129219_ChIP-ChIP_H3396_Human1.39097591
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37978538
52* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35844220
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33689749
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.28475670
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.27905206
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25355859
57* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23862413
58GABP_19822575_ChIP-Seq_HepG2_Human1.19618504
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17699131
60* SOX2_16153702_ChIP-ChIP_HESCs_Human1.16119494
61SCL_19346495_ChIP-Seq_HPC-7_Human1.14863136
62* SRF_21415370_ChIP-Seq_HL-1_Mouse1.13347372
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.13283344
64KDM5A_27292631_Chip-Seq_BREAST_Human1.11253202
65ZNF274_21170338_ChIP-Seq_K562_Hela1.10107439
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09883892
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08999984
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07683915
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06619150
70IGF1R_20145208_ChIP-Seq_DFB_Human1.06347531
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06281217
72CIITA_25753668_ChIP-Seq_RAJI_Human1.05843717
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.04937616
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04747245
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03254998
76BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94131894
77* NANOG_16153702_ChIP-ChIP_HESCs_Human0.92520029
78SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90873139
79FLI1_27457419_Chip-Seq_LIVER_Mouse0.90411730
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89336622
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88965667
82CBX2_27304074_Chip-Seq_ESCs_Mouse0.88937561
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87548215
84MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85902686
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84742796
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84742796
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84742796
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84174470
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83860841
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80859322
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78327420
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76641460
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76167078
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75709324
95AR_21909140_ChIP-Seq_LNCAP_Human0.74189318
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74011678
97TAF15_26573619_Chip-Seq_HEK293_Human0.73829106
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73433886
99* SPI1_23547873_ChIP-Seq_NB4_Human0.72828500
100RNF2_27304074_Chip-Seq_NSC_Mouse0.71329428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.91373945
2MP0006292_abnormal_olfactory_placode3.83405997
3MP0003136_yellow_coat_color2.55651816
4MP0008058_abnormal_DNA_repair2.50580348
5MP0002009_preneoplasia2.47420302
6MP0002938_white_spotting2.44525349
7MP0010094_abnormal_chromosome_stability2.37826601
8MP0008995_early_reproductive_senescence2.36115430
9MP0000566_synostosis2.34887080
10MP0002396_abnormal_hematopoietic_system2.12410420
11MP0001293_anophthalmia2.10254204
12MP0004957_abnormal_blastocyst_morpholog2.08595967
13MP0003806_abnormal_nucleotide_metabolis2.01538260
14MP0003693_abnormal_embryo_hatching1.93321533
15MP0003077_abnormal_cell_cycle1.92785951
16MP0005075_abnormal_melanosome_morpholog1.83177712
17MP0003567_abnormal_fetal_cardiomyocyte1.81102882
18MP0004147_increased_porphyrin_level1.77067576
19MP0006072_abnormal_retinal_apoptosis1.67924171
20MP0003315_abnormal_perineum_morphology1.63962557
21MP0010030_abnormal_orbit_morphology1.54236338
22MP0000372_irregular_coat_pigmentation1.50737325
23MP0005084_abnormal_gallbladder_morpholo1.48146392
24MP0002095_abnormal_skin_pigmentation1.47301288
25MP0002160_abnormal_reproductive_system1.45505757
26MP0001529_abnormal_vocalization1.44066358
27MP0000631_abnormal_neuroendocrine_gland1.41258556
28MP0008057_abnormal_DNA_replication1.38215814
29MP0001286_abnormal_eye_development1.35873720
30MP0001873_stomach_inflammation1.33457343
31MP0001188_hyperpigmentation1.29996958
32MP0008007_abnormal_cellular_replicative1.29529490
33MP0005174_abnormal_tail_pigmentation1.28497462
34MP0004808_abnormal_hematopoietic_stem1.25045904
35MP0002638_abnormal_pupillary_reflex1.22613788
36MP0009697_abnormal_copulation1.22424786
37MP0002234_abnormal_pharynx_morphology1.20399342
38MP0003718_maternal_effect1.17236072
39MP0008932_abnormal_embryonic_tissue1.16332081
40MP0003937_abnormal_limbs/digits/tail_de1.16227501
41MP0000049_abnormal_middle_ear1.15549310
42MP0003111_abnormal_nucleus_morphology1.15361517
43MP0008877_abnormal_DNA_methylation1.12125697
44MP0003890_abnormal_embryonic-extraembry1.10135043
45MP0003283_abnormal_digestive_organ1.08073921
46MP0003763_abnormal_thymus_physiology1.04113121
47MP0002210_abnormal_sex_determination1.01247422
48MP0008789_abnormal_olfactory_epithelium0.97446919
49MP0002653_abnormal_ependyma_morphology0.96423427
50MP0001346_abnormal_lacrimal_gland0.95416877
51MP0009333_abnormal_splenocyte_physiolog0.95340712
52MP0004142_abnormal_muscle_tone0.94476937
53MP0001145_abnormal_male_reproductive0.92605187
54MP0005389_reproductive_system_phenotype0.92546682
55MP0000490_abnormal_crypts_of0.90888846
56MP0001929_abnormal_gametogenesis0.90381086
57MP0003186_abnormal_redox_activity0.89149965
58MP0002928_abnormal_bile_duct0.88402005
59MP0000350_abnormal_cell_proliferation0.86223964
60MP0001986_abnormal_taste_sensitivity0.85711669
61MP0002102_abnormal_ear_morphology0.85458380
62MP0009250_abnormal_appendicular_skeleto0.83530890
63MP0002163_abnormal_gland_morphology0.82344234
64MP0002006_tumorigenesis0.82182070
65MP0000681_abnormal_thyroid_gland0.79943572
66MP0000653_abnormal_sex_gland0.79697172
67MP0003786_premature_aging0.78979934
68MP0001485_abnormal_pinna_reflex0.78481916
69MP0005645_abnormal_hypothalamus_physiol0.78128401
70MP0002084_abnormal_developmental_patter0.77768644
71MP0001835_abnormal_antigen_presentation0.77103466
72MP0000465_gastrointestinal_hemorrhage0.76505006
73MP0002166_altered_tumor_susceptibility0.76054942
74MP0005253_abnormal_eye_physiology0.76000313
75MP0005391_vision/eye_phenotype0.75563478
76MP0002697_abnormal_eye_size0.75404538
77MP0002233_abnormal_nose_morphology0.72610619
78MP0000537_abnormal_urethra_morphology0.71821197
79MP0000313_abnormal_cell_death0.71766011
80MP0003943_abnormal_hepatobiliary_system0.71706483
81MP0000678_abnormal_parathyroid_gland0.70651051
82MP0005499_abnormal_olfactory_system0.70621287
83MP0005394_taste/olfaction_phenotype0.70621287
84MP0002398_abnormal_bone_marrow0.69730647
85MP0001764_abnormal_homeostasis0.69613763
86MP0002019_abnormal_tumor_incidence0.69416213
87MP0003938_abnormal_ear_development0.69178231
88MP0002085_abnormal_embryonic_tissue0.69007165
89MP0000026_abnormal_inner_ear0.68966494
90MP0002932_abnormal_joint_morphology0.68597328
91MP0002249_abnormal_larynx_morphology0.68345689
92MP0002282_abnormal_trachea_morphology0.67905021
93MP0003878_abnormal_ear_physiology0.67053395
94MP0005377_hearing/vestibular/ear_phenot0.67053395
95MP0006276_abnormal_autonomic_nervous0.66784637
96MP0005551_abnormal_eye_electrophysiolog0.66782053
97MP0001697_abnormal_embryo_size0.65723600
98MP0003698_abnormal_male_reproductive0.64575304
99MP0003121_genomic_imprinting0.64563885
100MP0001672_abnormal_embryogenesis/_devel0.64309781

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.90546241
2Abnormality of cells of the erythroid lineage (HP:0012130)7.72910359
3Macrocytic anemia (HP:0001972)6.63076121
4Abnormal number of erythroid precursors (HP:0012131)6.42233525
5Pallor (HP:0000980)5.56076633
6Stenosis of the external auditory canal (HP:0000402)4.34748906
7Increased hepatocellular lipid droplets (HP:0006565)3.11884660
8Depressed nasal ridge (HP:0000457)3.00096335
9Triphalangeal thumb (HP:0001199)2.98575634
10Acute lymphatic leukemia (HP:0006721)2.94898060
11Panhypogammaglobulinemia (HP:0003139)2.79031605
12Acute necrotizing encephalopathy (HP:0006965)2.77154404
13Mitochondrial inheritance (HP:0001427)2.75866721
14Abnormal hemoglobin (HP:0011902)2.75739801
15Lipid accumulation in hepatocytes (HP:0006561)2.75573490
16Colon cancer (HP:0003003)2.75444840
17Renal Fanconi syndrome (HP:0001994)2.72966524
18Respiratory difficulties (HP:0002880)2.67629386
19Abnormality of the parietal bone (HP:0002696)2.64670064
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55969873
21Absent thumb (HP:0009777)2.54359881
22Abnormal mitochondria in muscle tissue (HP:0008316)2.49006418
23Increased CSF lactate (HP:0002490)2.45349039
24Acute encephalopathy (HP:0006846)2.43843377
25Hepatocellular necrosis (HP:0001404)2.42540442
26Abnormality of reticulocytes (HP:0004312)2.42389352
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.41858400
28Congenital, generalized hypertrichosis (HP:0004540)2.40152168
29Thrombocytosis (HP:0001894)2.39682882
30Thick lower lip vermilion (HP:0000179)2.28532638
31Septo-optic dysplasia (HP:0100842)2.27484877
32Aplastic anemia (HP:0001915)2.26160481
33Hepatic necrosis (HP:0002605)2.22373272
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22032323
35Increased intramyocellular lipid droplets (HP:0012240)2.21834539
36Reduced antithrombin III activity (HP:0001976)2.17703971
373-Methylglutaconic aciduria (HP:0003535)2.17015877
38Migraine (HP:0002076)2.17005741
39Progressive macrocephaly (HP:0004481)2.16507321
40Short middle phalanx of the 5th finger (HP:0004220)2.12608732
41Optic disc pallor (HP:0000543)2.12086170
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.08306730
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07361615
44Asplenia (HP:0001746)2.01100579
45Myelodysplasia (HP:0002863)2.00630107
46Constricted visual fields (HP:0001133)2.00565064
47Abnormality of the preputium (HP:0100587)1.99837090
48Abnormal rod and cone electroretinograms (HP:0008323)1.99252824
49Aplasia/Hypoplasia of the uvula (HP:0010293)1.98866420
50Abnormality of the renal collecting system (HP:0004742)1.98033879
51Abnormality of midbrain morphology (HP:0002418)1.97463161
52Molar tooth sign on MRI (HP:0002419)1.97463161
53Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.97462051
54Chromsome breakage (HP:0040012)1.95100387
55Abnormality of DNA repair (HP:0003254)1.93828095
56Pancreatic cysts (HP:0001737)1.93130648
57Abnormality of cochlea (HP:0000375)1.92437132
58Partial duplication of thumb phalanx (HP:0009944)1.91740632
59Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.91539315
60Agammaglobulinemia (HP:0004432)1.91433429
61Cerebral edema (HP:0002181)1.90297316
62Aplasia/Hypoplasia of the spleen (HP:0010451)1.90126916
63Absent/shortened dynein arms (HP:0200106)1.86108486
64Dynein arm defect of respiratory motile cilia (HP:0012255)1.86108486
65Pancreatic fibrosis (HP:0100732)1.86097680
66Morphological abnormality of the inner ear (HP:0011390)1.84783130
67B lymphocytopenia (HP:0010976)1.84749870
68Type 2 muscle fiber atrophy (HP:0003554)1.81676475
69Generalized aminoaciduria (HP:0002909)1.80333161
7011 pairs of ribs (HP:0000878)1.79976174
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76660135
72Exertional dyspnea (HP:0002875)1.75294077
73Abnormality of renal resorption (HP:0011038)1.74583205
74Acute myeloid leukemia (HP:0004808)1.74212649
75Abnormality of B cell number (HP:0010975)1.73807388
76Renal cortical cysts (HP:0000803)1.73564130
77Duplication of thumb phalanx (HP:0009942)1.72486485
78Microvesicular hepatic steatosis (HP:0001414)1.72415108
79Abnormal ciliary motility (HP:0012262)1.71587700
80Hypoplasia of the radius (HP:0002984)1.71565590
81Hyperglycinemia (HP:0002154)1.70865572
82Meckel diverticulum (HP:0002245)1.70488562
83Central scotoma (HP:0000603)1.70394952
84Abnormality of chromosome stability (HP:0003220)1.69513461
85Oral leukoplakia (HP:0002745)1.69465321
86Partial duplication of the phalanx of hand (HP:0009999)1.68672696
87Increased muscle lipid content (HP:0009058)1.68260943
88Missing ribs (HP:0000921)1.68165481
89Volvulus (HP:0002580)1.66859196
90Increased serum lactate (HP:0002151)1.66498179
91Type I transferrin isoform profile (HP:0003642)1.66265936
92IgM deficiency (HP:0002850)1.65695001
93Abnormality of the ileum (HP:0001549)1.65261341
94True hermaphroditism (HP:0010459)1.64756518
95Congenital stationary night blindness (HP:0007642)1.64466519
96Glycosuria (HP:0003076)1.64321009
97Abnormality of urine glucose concentration (HP:0011016)1.64321009
98Lactic acidosis (HP:0003128)1.61452454
99Horseshoe kidney (HP:0000085)1.59933609
100Nephronophthisis (HP:0000090)1.59790110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.74991897
2PASK4.13938901
3VRK23.51340161
4CDC72.67411372
5RPS6KB22.46168683
6NUAK12.38451543
7SCYL22.35355693
8KIT2.35003027
9VRK12.33934600
10INSRR2.25969615
11FLT32.24604833
12PBK2.18331815
13MKNK12.17164858
14ZAK2.07999564
15EIF2AK32.06329368
16NME21.95437548
17TAF11.92481976
18PLK41.76669785
19STK161.75719974
20TGFBR11.75571986
21CDK31.64961296
22NEK21.60154972
23WEE11.57752648
24MAP3K101.46583006
25TEC1.27149007
26TLK11.25248306
27SRPK11.23382765
28NME11.22506770
29BUB11.22224863
30CHEK21.17046257
31PNCK1.13173002
32TTK1.12325590
33AURKB1.10487699
34BRSK21.10082254
35TAOK31.08519162
36BCKDK1.06568999
37NLK1.04827822
38RPS6KA41.04679811
39LATS11.04099490
40LRRK20.97729312
41ATR0.90865471
42CDK80.89250129
43NEK10.89145533
44PLK30.88597526
45MAP4K20.88510595
46ILK0.87461562
47CSNK2A20.84526213
48DYRK20.83698064
49CSF1R0.83401438
50CDK40.82077227
51BTK0.80130187
52CCNB10.80006407
53RPS6KA60.79994836
54RPS6KL10.79529046
55RPS6KC10.79529046
56MATK0.79441443
57MAPK150.78539278
58DYRK30.76764193
59BMPR1B0.74455219
60DAPK30.73155126
61ITK0.73124689
62EIF2AK20.72659177
63PLK10.71211949
64PIM10.70135533
65TXK0.69732429
66SYK0.69635761
67TIE10.68250874
68MKNK20.65423740
69STK30.64317641
70MAPK70.60911916
71EPHB20.59690032
72CSNK2A10.58829174
73FGFR20.58688374
74CDK70.57720560
75BMPR20.56383707
76ATM0.55051414
77AURKA0.52848487
78RPS6KA50.52348761
79RPS6KB10.51243079
80GRK10.49111864
81CHEK10.47478965
82TRPM70.45070803
83PAK20.44149041
84MAPKAPK50.43704517
85DYRK1B0.43245556
86CDK20.42696523
87STK40.42401798
88MAP4K10.41366856
89LYN0.40804620
90WNK30.40526587
91CDK60.38958591
92OXSR10.38261007
93BRD40.38148703
94DYRK1A0.37591652
95IKBKB0.37489074
96CSNK1E0.37398165
97TSSK60.36160439
98PRKCD0.34084227
99IKBKE0.34076090
100LCK0.31361681

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.17769724
2Oxidative phosphorylation_Homo sapiens_hsa001903.07209063
3DNA replication_Homo sapiens_hsa030302.88121497
4Mismatch repair_Homo sapiens_hsa034302.80463709
5Parkinsons disease_Homo sapiens_hsa050122.74615759
6Homologous recombination_Homo sapiens_hsa034402.44892459
7RNA polymerase_Homo sapiens_hsa030202.41235457
8Spliceosome_Homo sapiens_hsa030402.29870778
9Proteasome_Homo sapiens_hsa030502.19569602
10Nucleotide excision repair_Homo sapiens_hsa034202.16475160
11Asthma_Homo sapiens_hsa053102.05812443
12Huntingtons disease_Homo sapiens_hsa050162.05143888
13RNA transport_Homo sapiens_hsa030131.89491173
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88224189
15Protein export_Homo sapiens_hsa030601.87975709
16Fanconi anemia pathway_Homo sapiens_hsa034601.85846258
17Base excision repair_Homo sapiens_hsa034101.85088303
18RNA degradation_Homo sapiens_hsa030181.84294117
19Alzheimers disease_Homo sapiens_hsa050101.74158151
20Non-homologous end-joining_Homo sapiens_hsa034501.55412668
21One carbon pool by folate_Homo sapiens_hsa006701.54838578
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51815619
23Allograft rejection_Homo sapiens_hsa053301.51785746
24Pyrimidine metabolism_Homo sapiens_hsa002401.47756136
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.40653408
26Basal transcription factors_Homo sapiens_hsa030221.38077916
27Cardiac muscle contraction_Homo sapiens_hsa042601.37370896
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30966227
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23646956
30Autoimmune thyroid disease_Homo sapiens_hsa053201.22147193
31Purine metabolism_Homo sapiens_hsa002301.19952699
32Type I diabetes mellitus_Homo sapiens_hsa049401.13705326
33Cell cycle_Homo sapiens_hsa041101.11130882
34Systemic lupus erythematosus_Homo sapiens_hsa053221.05267335
35Graft-versus-host disease_Homo sapiens_hsa053321.04941121
36Primary immunodeficiency_Homo sapiens_hsa053401.01923586
37mRNA surveillance pathway_Homo sapiens_hsa030150.98261711
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95581700
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90105512
40Linoleic acid metabolism_Homo sapiens_hsa005910.83243252
41Propanoate metabolism_Homo sapiens_hsa006400.81814738
42Antigen processing and presentation_Homo sapiens_hsa046120.76158727
43Basal cell carcinoma_Homo sapiens_hsa052170.73493561
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73184441
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71537638
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.69560885
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69122269
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68946528
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.65602132
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63257067
51Arachidonic acid metabolism_Homo sapiens_hsa005900.61541247
52Selenocompound metabolism_Homo sapiens_hsa004500.60449730
53Olfactory transduction_Homo sapiens_hsa047400.59185370
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.55006314
55Butanoate metabolism_Homo sapiens_hsa006500.53144933
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52361201
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50068735
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48913238
59p53 signaling pathway_Homo sapiens_hsa041150.48303649
60N-Glycan biosynthesis_Homo sapiens_hsa005100.46896486
61Metabolic pathways_Homo sapiens_hsa011000.46568226
62Peroxisome_Homo sapiens_hsa041460.46563563
63Glutathione metabolism_Homo sapiens_hsa004800.45100642
64Ether lipid metabolism_Homo sapiens_hsa005650.43843242
65Epstein-Barr virus infection_Homo sapiens_hsa051690.43456935
66Phototransduction_Homo sapiens_hsa047440.43345130
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43088702
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42972732
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.42312248
70Hedgehog signaling pathway_Homo sapiens_hsa043400.41423435
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40879610
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40658037
73Herpes simplex infection_Homo sapiens_hsa051680.38138297
74Chemical carcinogenesis_Homo sapiens_hsa052040.36940236
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34321051
76Retinol metabolism_Homo sapiens_hsa008300.34143168
77Regulation of autophagy_Homo sapiens_hsa041400.31857708
78Taste transduction_Homo sapiens_hsa047420.30527181
79Alcoholism_Homo sapiens_hsa050340.30402312
80Hematopoietic cell lineage_Homo sapiens_hsa046400.30244686
81Leishmaniasis_Homo sapiens_hsa051400.28718839
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28222790
83HTLV-I infection_Homo sapiens_hsa051660.27987765
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27400073
85African trypanosomiasis_Homo sapiens_hsa051430.25987736
86Nitrogen metabolism_Homo sapiens_hsa009100.24873765
87Pyruvate metabolism_Homo sapiens_hsa006200.24332419
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24153100
89Fat digestion and absorption_Homo sapiens_hsa049750.22201979
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19256422
91Wnt signaling pathway_Homo sapiens_hsa043100.18359381
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18043373
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17589578
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15931426
95Viral myocarditis_Homo sapiens_hsa054160.15282212
96Vitamin digestion and absorption_Homo sapiens_hsa049770.14470301
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13978881
98Folate biosynthesis_Homo sapiens_hsa007900.13150661
99Rheumatoid arthritis_Homo sapiens_hsa053230.12788456
100Carbon metabolism_Homo sapiens_hsa012000.11465203

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