ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.72271380
2	ATP synthesis coupled proton transport (GO:0015986)	5.72271380
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.56862202
4	ribosomal small subunit assembly (GO:0000028)	4.84507549
5	viral transcription (GO:0019083)	4.66749150
6	translational termination (GO:0006415)	4.57650628
7	ribosomal large subunit biogenesis (GO:0042273)	4.43333313
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.39664955
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.25452367
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.23205010
11	cotranslational protein targeting to membrane (GO:0006613)	4.17033863
12	protein targeting to ER (GO:0045047)	4.16331888
13	protein neddylation (GO:0045116)	4.15290478
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.00671947
15	protein localization to endoplasmic reticulum (GO:0070972)	3.98543491
16	respiratory electron transport chain (GO:0022904)	3.98520510
17	electron transport chain (GO:0022900)	3.98478806
18	behavioral response to nicotine (GO:0035095)	3.94021847
19	translational elongation (GO:0006414)	3.92921562
20	protein complex biogenesis (GO:0070271)	3.91026961
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.81825071
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.81825071
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.78850968
24	NADH dehydrogenase complex assembly (GO:0010257)	3.78850968
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.78850968
26	maturation of SSU-rRNA (GO:0030490)	3.77455731
27	response to pheromone (GO:0019236)	3.74115396
28	DNA deamination (GO:0045006)	3.59209598
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.51619399
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.42358608
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41168931
32	proteasome assembly (GO:0043248)	3.41016454
33	viral life cycle (GO:0019058)	3.36371403
34	cellular protein complex disassembly (GO:0043624)	3.34281822
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.33439589
36	translational initiation (GO:0006413)	3.31463547
37	translation (GO:0006412)	3.22282676
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.18847201
39	ATP biosynthetic process (GO:0006754)	3.18727661
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.18398326
41	GTP biosynthetic process (GO:0006183)	3.17355432
42	platelet dense granule organization (GO:0060155)	3.11749236
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.09812201
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.09483804
45	termination of RNA polymerase III transcription (GO:0006386)	3.09483804
46	protein polyglutamylation (GO:0018095)	3.08782147
47	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.06202172
48	ribosomal small subunit biogenesis (GO:0042274)	3.05981892
49	hydrogen ion transmembrane transport (GO:1902600)	3.05803181
50	aldehyde catabolic process (GO:0046185)	3.05336375
51	chaperone-mediated protein transport (GO:0072321)	3.04560097
52	tryptophan catabolic process (GO:0006569)	3.01385890
53	indole-containing compound catabolic process (GO:0042436)	3.01385890
54	indolalkylamine catabolic process (GO:0046218)	3.01385890
55	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.00431467
56	proton transport (GO:0015992)	2.95009245
57	hydrogen transport (GO:0006818)	2.91904126
58	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82527013
59	indolalkylamine metabolic process (GO:0006586)	2.82268048
60	respiratory chain complex IV assembly (GO:0008535)	2.82155708
61	kynurenine metabolic process (GO:0070189)	2.78786546
62	water-soluble vitamin biosynthetic process (GO:0042364)	2.77098759
63	piRNA metabolic process (GO:0034587)	2.75851373
64	replication fork processing (GO:0031297)	2.75578489
65	regulation of cellular respiration (GO:0043457)	2.74552287
66	protein complex disassembly (GO:0043241)	2.71029136
67	negative regulation of mast cell activation (GO:0033004)	2.70854996
68	protein targeting to membrane (GO:0006612)	2.69449790
69	cellular component biogenesis (GO:0044085)	2.68202350
70	tRNA processing (GO:0008033)	2.67565264
71	macromolecular complex disassembly (GO:0032984)	2.67235847
72	GPI anchor metabolic process (GO:0006505)	2.67175235
73	negative regulation of heart rate (GO:0010459)	2.66953994
74	tryptophan metabolic process (GO:0006568)	2.66424536
75	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.65785464
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.63886229
77	prenylation (GO:0097354)	2.63825652
78	protein prenylation (GO:0018342)	2.63825652
79	organelle disassembly (GO:1903008)	2.62849942
80	cytochrome complex assembly (GO:0017004)	2.61110881
81	regulation of cellular amino acid metabolic process (GO:0006521)	2.59805940
82	regulation of isotype switching to IgG isotypes (GO:0048302)	2.58291248
83	GPI anchor biosynthetic process (GO:0006506)	2.54662607
84	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.53626395
85	mannosylation (GO:0097502)	2.51851251
86	regulation of interleukin-8 secretion (GO:2000482)	2.51608466
87	UTP biosynthetic process (GO:0006228)	2.51245426
88	recombinational repair (GO:0000725)	2.50067886
89	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.49130336
90	rRNA processing (GO:0006364)	2.49009817
91	rRNA metabolic process (GO:0016072)	2.48923366
92	protein-cofactor linkage (GO:0018065)	2.48465660
93	double-strand break repair via homologous recombination (GO:0000724)	2.47585435
94	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.47258781
95	axoneme assembly (GO:0035082)	2.44641376
96	negative regulation of T cell differentiation in thymus (GO:0033085)	2.44558902
97	regulation of cilium movement (GO:0003352)	2.43318755
98	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.42005215
99	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.42005215
100	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.42005215

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.97513196
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.44858637
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.25069472
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.24983917
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19200851
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17864471
7	VDR_22108803_ChIP-Seq_LS180_Human	3.07780302
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.75906076
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.65652925
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31373156
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.17877820
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.13696924
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.13312410
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11972489
15	EWS_26573619_Chip-Seq_HEK293_Human	2.08731505
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.05844457
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.04959410
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.93015707
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92905767
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92091254
21	FUS_26573619_Chip-Seq_HEK293_Human	1.91671196
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87115935
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86038229
24	P300_19829295_ChIP-Seq_ESCs_Human	1.73545095
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69320265
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.68320475
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66011180
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65201950
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.65142741
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.64549134
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59713029
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56569382
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.55876803
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54660979
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53011770
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51710886
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49954087
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.48259800
39	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.45931245
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44957090
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.43976959
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43490395
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43490395
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.40966389
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39431681
46	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.39232623
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.39088717
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39088717
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37926021
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37926021
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36280432
52	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35158204
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.34312220
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34267050
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31636047
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24564215
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21637237
58	AR_20517297_ChIP-Seq_VCAP_Human	1.20575714
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18258863
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17448674
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.17143676
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16555391
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16503468
64	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15359282
65	GATA3_26560356_Chip-Seq_TH2_Human	1.15318359
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14833075
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14680587
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.14562995
69	NCOR_22424771_ChIP-Seq_293T_Human	1.12931959
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11161442
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10798720
72	TTF2_22483619_ChIP-Seq_HELA_Human	1.09430472
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09020564
74	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.08671221
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07143818
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04353539
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04322415
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02152780
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00920478
80	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00650656
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00352636
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99851931
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98516503
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98156070
85	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.94918529
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94820087
87	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94314301
88	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94300430
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94047612
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93282576
91	AR_25329375_ChIP-Seq_VCAP_Human	0.92567670
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.92563070
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.91950851
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.91538332
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90610056
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90384217
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.90164209
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90015944
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89911857
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.89708916

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.43737856
2	MP0001835_abnormal_antigen_presentation	2.92200217
3	MP0006292_abnormal_olfactory_placode	2.79791929
4	MP0000372_irregular_coat_pigmentation	2.42155348
5	MP0008872_abnormal_physiological_respon	2.26337491
6	MP0003806_abnormal_nucleotide_metabolis	2.20544874
7	MP0003646_muscle_fatigue	2.19317660
8	MP0005646_abnormal_pituitary_gland	2.19278003
9	MP0004142_abnormal_muscle_tone	2.18820635
10	MP0005671_abnormal_response_to	2.18243954
11	MP0002837_dystrophic_cardiac_calcinosis	2.13312286
12	MP0006072_abnormal_retinal_apoptosis	2.04669177
13	MP0004145_abnormal_muscle_electrophysio	2.01423536
14	MP0001968_abnormal_touch/_nociception	1.97190948
15	MP0008877_abnormal_DNA_methylation	1.95913711
16	MP0005551_abnormal_eye_electrophysiolog	1.95382944
17	MP0004885_abnormal_endolymph	1.95348133
18	MP0008875_abnormal_xenobiotic_pharmacok	1.94767800
19	MP0003880_abnormal_central_pattern	1.91255837
20	MP0002102_abnormal_ear_morphology	1.86674532
21	MP0002876_abnormal_thyroid_physiology	1.81524973
22	MP0003186_abnormal_redox_activity	1.79063385
23	MP0002736_abnormal_nociception_after	1.77865706
24	MP0005084_abnormal_gallbladder_morpholo	1.74560848
25	MP0003195_calcinosis	1.70828306
26	MP0004147_increased_porphyrin_level	1.68448461
27	MP0003136_yellow_coat_color	1.61931789
28	MP0005075_abnormal_melanosome_morpholog	1.60095849
29	MP0001984_abnormal_olfaction	1.52529352
30	MP0005645_abnormal_hypothalamus_physiol	1.42843392
31	MP0008789_abnormal_olfactory_epithelium	1.42446510
32	MP0005174_abnormal_tail_pigmentation	1.41339920
33	MP0001986_abnormal_taste_sensitivity	1.36932278
34	MP0002272_abnormal_nervous_system	1.34364116
35	MP0002234_abnormal_pharynx_morphology	1.33197006
36	MP0005389_reproductive_system_phenotype	1.33174234
37	MP0002148_abnormal_hypersensitivity_rea	1.32606105
38	MP0005253_abnormal_eye_physiology	1.30853862
39	MP0001873_stomach_inflammation	1.30424334
40	MP0001800_abnormal_humoral_immune	1.29020303
41	MP0003787_abnormal_imprinting	1.23163063
42	MP0001919_abnormal_reproductive_system	1.20803354
43	MP0001905_abnormal_dopamine_level	1.20767133
44	MP0002938_white_spotting	1.20605141
45	MP0009745_abnormal_behavioral_response	1.20518603
46	MP0002163_abnormal_gland_morphology	1.17496227
47	MP0001485_abnormal_pinna_reflex	1.16292571
48	MP0003878_abnormal_ear_physiology	1.15976071
49	MP0005377_hearing/vestibular/ear_phenot	1.15976071
50	MP0001440_abnormal_grooming_behavior	1.15558409
51	MP0009764_decreased_sensitivity_to	1.15542531
52	MP0005670_abnormal_white_adipose	1.15094939
53	MP0003718_maternal_effect	1.14773840
54	MP0002095_abnormal_skin_pigmentation	1.14400350
55	MP0009785_altered_susceptibility_to	1.13687942
56	MP0008058_abnormal_DNA_repair	1.11572423
57	MP0001970_abnormal_pain_threshold	1.09333341
58	MP0000631_abnormal_neuroendocrine_gland	1.08514141
59	MP0001293_anophthalmia	1.07706455
60	MP0001529_abnormal_vocalization	1.06126573
61	MP0001486_abnormal_startle_reflex	1.06095126
62	MP0002160_abnormal_reproductive_system	1.04382803
63	MP0006036_abnormal_mitochondrial_physio	1.03275155
64	MP0003724_increased_susceptibility_to	1.02974619
65	MP0005360_urolithiasis	1.01733263
66	MP0000685_abnormal_immune_system	0.99546257
67	MP0005410_abnormal_fertilization	0.97399298
68	MP0010386_abnormal_urinary_bladder	0.94313503
69	MP0003786_premature_aging	0.91898293
70	MP0005000_abnormal_immune_tolerance	0.89030783
71	MP0001501_abnormal_sleep_pattern	0.88176643
72	MP0004742_abnormal_vestibular_system	0.88017125
73	MP0002138_abnormal_hepatobiliary_system	0.86407524
74	MP0005636_abnormal_mineral_homeostasis	0.86398703
75	MP0003011_delayed_dark_adaptation	0.85929835
76	MP0002928_abnormal_bile_duct	0.85857230
77	MP0005332_abnormal_amino_acid	0.84632276
78	MP0002733_abnormal_thermal_nociception	0.83596023
79	MP0006276_abnormal_autonomic_nervous	0.83535457
80	MP0009697_abnormal_copulation	0.83438729
81	MP0005195_abnormal_posterior_eye	0.81813580
82	MP0005379_endocrine/exocrine_gland_phen	0.81478723
83	MP0001790_abnormal_immune_system	0.81194714
84	MP0005387_immune_system_phenotype	0.81194714
85	MP0004043_abnormal_pH_regulation	0.81143257
86	MP0002452_abnormal_antigen_presenting	0.80956697
87	MP0000427_abnormal_hair_cycle	0.80569881
88	MP0002557_abnormal_social/conspecific_i	0.80385045
89	MP0001502_abnormal_circadian_rhythm	0.80314844
90	MP0002723_abnormal_immune_serum	0.79739156
91	MP0002277_abnormal_respiratory_mucosa	0.78963266
92	MP0003866_abnormal_defecation	0.78600827
93	MP0005499_abnormal_olfactory_system	0.78136194
94	MP0005394_taste/olfaction_phenotype	0.78136194
95	MP0005171_absent_coat_pigmentation	0.77575296
96	MP0000516_abnormal_urinary_system	0.76727565
97	MP0005367_renal/urinary_system_phenotyp	0.76727565
98	MP0002638_abnormal_pupillary_reflex	0.76277135
99	MP0008995_early_reproductive_senescence	0.75697694
100	MP0008775_abnormal_heart_ventricle	0.75358463

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.31620252
2	Mitochondrial inheritance (HP:0001427)	3.94917952
3	Acute encephalopathy (HP:0006846)	3.83326055
4	Progressive macrocephaly (HP:0004481)	3.83221859
5	Increased CSF lactate (HP:0002490)	3.75824428
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.69872100
7	Congenital stationary night blindness (HP:0007642)	3.69845258
8	Hepatocellular necrosis (HP:0001404)	3.58247169
9	3-Methylglutaconic aciduria (HP:0003535)	3.55252963
10	Abnormality of midbrain morphology (HP:0002418)	3.54328926
11	Molar tooth sign on MRI (HP:0002419)	3.54328926
12	Increased hepatocellular lipid droplets (HP:0006565)	3.47556544
13	Pancreatic cysts (HP:0001737)	3.36499599
14	Lipid accumulation in hepatocytes (HP:0006561)	3.32362677
15	Hepatic necrosis (HP:0002605)	3.18950346
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.16246183
17	Pancreatic fibrosis (HP:0100732)	3.14142321
18	Nephronophthisis (HP:0000090)	3.02177284
19	Reticulocytopenia (HP:0001896)	3.00986339
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.98219824
21	Absent/shortened dynein arms (HP:0200106)	2.98219824
22	Congenital, generalized hypertrichosis (HP:0004540)	2.87596496
23	Abolished electroretinogram (ERG) (HP:0000550)	2.87172800
24	True hermaphroditism (HP:0010459)	2.86411613
25	Cerebral edema (HP:0002181)	2.84996641
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.83535038
27	Renal Fanconi syndrome (HP:0001994)	2.77012713
28	Exertional dyspnea (HP:0002875)	2.72585258
29	Optic disc pallor (HP:0000543)	2.70390602
30	Medial flaring of the eyebrow (HP:0010747)	2.64910394
31	Abnormality of the renal medulla (HP:0100957)	2.61500087
32	Abnormality of the renal cortex (HP:0011035)	2.56799189
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.55340305
34	IgG deficiency (HP:0004315)	2.54382657
35	Type II lissencephaly (HP:0007260)	2.49143038
36	Macrocytic anemia (HP:0001972)	2.42916108
37	Increased serum lactate (HP:0002151)	2.39949850
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.39498083
39	Attenuation of retinal blood vessels (HP:0007843)	2.36678084
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.35683949
41	Hypoproteinemia (HP:0003075)	2.35569548
42	Abnormality of the prostate (HP:0008775)	2.35565751
43	Colon cancer (HP:0003003)	2.34243293
44	Asplenia (HP:0001746)	2.33546848
45	Sclerocornea (HP:0000647)	2.28796696
46	Decreased central vision (HP:0007663)	2.28394487
47	Stomach cancer (HP:0012126)	2.27569954
48	Renal cortical cysts (HP:0000803)	2.25743056
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25435850
50	Lactic acidosis (HP:0003128)	2.21569682
51	Bile duct proliferation (HP:0001408)	2.19220756
52	Abnormal biliary tract physiology (HP:0012439)	2.19220756
53	Respiratory failure (HP:0002878)	2.15081767
54	Elevated erythrocyte sedimentation rate (HP:0003565)	2.14441742
55	Abnormal number of erythroid precursors (HP:0012131)	2.13906630
56	Constricted visual fields (HP:0001133)	2.12237698
57	Increased intramyocellular lipid droplets (HP:0012240)	2.08741027
58	Absent thumb (HP:0009777)	2.07898551
59	Leukodystrophy (HP:0002415)	2.07880675
60	Abnormality of renal resorption (HP:0011038)	1.99842664
61	Lethargy (HP:0001254)	1.98574879
62	Cystic liver disease (HP:0006706)	1.96769581
63	Hypothermia (HP:0002045)	1.96215436
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.95528293
65	Pallor (HP:0000980)	1.94807508
66	Abnormal ciliary motility (HP:0012262)	1.94691900
67	Stenosis of the external auditory canal (HP:0000402)	1.94604229
68	Congenital primary aphakia (HP:0007707)	1.94447630
69	Gait imbalance (HP:0002141)	1.94023393
70	Glycosuria (HP:0003076)	1.90526670
71	Abnormality of urine glucose concentration (HP:0011016)	1.90526670
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.89218220
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.89218220
74	Abnormality of B cell number (HP:0010975)	1.88547914
75	Methylmalonic acidemia (HP:0002912)	1.87925937
76	Chronic hepatic failure (HP:0100626)	1.86983955
77	Keratoconus (HP:0000563)	1.85528073
78	Increased corneal curvature (HP:0100692)	1.85528073
79	Abnormality of the pons (HP:0007361)	1.84809535
80	Abnormality of DNA repair (HP:0003254)	1.83585152
81	Pendular nystagmus (HP:0012043)	1.81210487
82	Male pseudohermaphroditism (HP:0000037)	1.80833162
83	Septo-optic dysplasia (HP:0100842)	1.80762910
84	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.79616861
85	Type I transferrin isoform profile (HP:0003642)	1.78377214
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.78313765
87	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78313765
88	Supernumerary spleens (HP:0009799)	1.77409149
89	Respiratory difficulties (HP:0002880)	1.76475332
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76400893
91	Abnormality of alanine metabolism (HP:0010916)	1.76400893
92	Hyperalaninemia (HP:0003348)	1.76400893
93	Nephrogenic diabetes insipidus (HP:0009806)	1.75314084
94	Cerebellar dysplasia (HP:0007033)	1.73777733
95	Hypoplasia of the pons (HP:0012110)	1.73753274
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.73496104
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72113412
98	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.71202853
99	Increased muscle lipid content (HP:0009058)	1.70247600
100	Stomatitis (HP:0010280)	1.69599282

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	2.97954386
2	MAP3K12	2.90631527
3	TAOK3	2.86087122
4	MAP4K2	2.77781218
5	FRK	2.69889673
6	ZAK	2.66992925
7	WNK3	2.59403526
8	TLK1	2.58382387
9	CDK19	2.33705530
10	WNK4	2.28359403
11	ADRBK2	2.27228042
12	GRK1	2.22476291
13	TXK	2.10761410
14	BMPR1B	2.04989892
15	OXSR1	1.91712417
16	BMPR2	1.82381751
17	STK39	1.82273625
18	TIE1	1.81492696
19	PINK1	1.75247522
20	VRK2	1.69096171
21	EIF2AK3	1.59502946
22	BCKDK	1.53994363
23	TEC	1.47110308
24	TNIK	1.46592855
25	NME1	1.43772777
26	DYRK2	1.31419319
27	VRK1	1.30579296
28	MST4	1.23680012
29	STK16	1.16196874
30	ACVR1B	1.13426351
31	INSRR	1.12564853
32	KIT	1.11838564
33	DAPK2	1.08051784
34	MYLK	1.07892847
35	EIF2AK1	1.04012386
36	ITK	0.99948220
37	FLT3	0.97683686
38	IKBKB	0.97626469
39	BUB1	0.95137422
40	MKNK1	0.94418691
41	PLK4	0.90206560
42	MKNK2	0.88462854
43	PIK3CA	0.87566876
44	CSNK1G3	0.87276709
45	PNCK	0.85368880
46	TAF1	0.84892608
47	WNK1	0.82290602
48	MAPK13	0.81072484
49	CSNK1G2	0.79902882
50	PLK3	0.78813325
51	PHKG1	0.77372335
52	PHKG2	0.77372335
53	CDC7	0.76711644
54	DAPK3	0.76588098
55	GRK6	0.75985893
56	GRK5	0.75103326
57	DAPK1	0.74834551
58	ERBB3	0.73321279
59	TRIM28	0.72333435
60	CSNK1G1	0.68241749
61	PRKCQ	0.64917298
62	SYK	0.64609879
63	MAP2K6	0.64462189
64	ADRBK1	0.64066569
65	PRKCE	0.61957911
66	ILK	0.60777881
67	PDK2	0.60672396
68	CSNK1A1L	0.60448319
69	KDR	0.58933439
70	TGFBR1	0.58583701
71	MAPKAPK5	0.58494684
72	LYN	0.57477412
73	EIF2AK2	0.57038836
74	WEE1	0.56579578
75	MARK3	0.56396267
76	PIK3CG	0.54088288
77	MAP4K1	0.53016808
78	PASK	0.52291479
79	RPS6KA5	0.51957465
80	PIM1	0.51730411
81	OBSCN	0.49066361
82	FES	0.48834743
83	NME2	0.47857021
84	NEK1	0.46957653
85	PRKACA	0.45870948
86	IGF1R	0.45633485
87	BTK	0.45059234
88	PRKCG	0.44870662
89	CSNK2A2	0.44667020
90	EPHA4	0.43772677
91	PLK1	0.43650886
92	CASK	0.43206171
93	AURKB	0.40954747
94	PAK3	0.40934581
95	ATR	0.40718973
96	CSF1R	0.40640834
97	MAP2K2	0.40541218
98	PRKCA	0.38925580
99	TRPM7	0.38144896
100	MINK1	0.37699669

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.26142546
2	Ribosome_Homo sapiens_hsa03010	3.71464180
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.52042878
4	Allograft rejection_Homo sapiens_hsa05330	3.16327789
5	Proteasome_Homo sapiens_hsa03050	3.10950242
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.08718240
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.96394606
8	Parkinsons disease_Homo sapiens_hsa05012	2.91994394
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.71534577
10	Protein export_Homo sapiens_hsa03060	2.53859434
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.50981340
12	RNA polymerase_Homo sapiens_hsa03020	1.93273006
13	Alzheimers disease_Homo sapiens_hsa05010	1.90539166
14	Huntingtons disease_Homo sapiens_hsa05016	1.82975091
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.81894298
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79447103
17	Homologous recombination_Homo sapiens_hsa03440	1.76761074
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68879941
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63571563
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63206229
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47903473
22	Phototransduction_Homo sapiens_hsa04744	1.46954016
23	RNA degradation_Homo sapiens_hsa03018	1.43827952
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.36083280
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35896102
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.35280096
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.33865804
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31547609
29	Propanoate metabolism_Homo sapiens_hsa00640	1.28112194
30	Basal transcription factors_Homo sapiens_hsa03022	1.22322757
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13996318
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13256366
33	Mismatch repair_Homo sapiens_hsa03430	1.11413572
34	Caffeine metabolism_Homo sapiens_hsa00232	1.10277821
35	One carbon pool by folate_Homo sapiens_hsa00670	1.09184871
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.03595290
37	Viral myocarditis_Homo sapiens_hsa05416	1.02406737
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.98585739
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.95845506
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.95424884
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93387327
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.89134511
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86675451
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86660045
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86544299
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82296658
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82219341
48	Regulation of autophagy_Homo sapiens_hsa04140	0.81475208
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80491070
50	Base excision repair_Homo sapiens_hsa03410	0.79026933
51	Peroxisome_Homo sapiens_hsa04146	0.77103044
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.76656460
53	Purine metabolism_Homo sapiens_hsa00230	0.74138831
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73192733
55	Nicotine addiction_Homo sapiens_hsa05033	0.72495185
56	RNA transport_Homo sapiens_hsa03013	0.71927108
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.71502490
58	Olfactory transduction_Homo sapiens_hsa04740	0.70003548
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69699126
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66878049
61	Leishmaniasis_Homo sapiens_hsa05140	0.66568186
62	Spliceosome_Homo sapiens_hsa03040	0.66338954
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66301096
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65534706
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63762249
66	Retinol metabolism_Homo sapiens_hsa00830	0.61620993
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61246536
68	Butanoate metabolism_Homo sapiens_hsa00650	0.59587728
69	DNA replication_Homo sapiens_hsa03030	0.57854526
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57691634
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55983404
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52575104
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52488571
74	Salivary secretion_Homo sapiens_hsa04970	0.51459297
75	Metabolic pathways_Homo sapiens_hsa01100	0.51156845
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.48149493
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.46074543
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44043758
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40403679
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39590663
81	Morphine addiction_Homo sapiens_hsa05032	0.39235696
82	Sulfur metabolism_Homo sapiens_hsa00920	0.38704413
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36631567
84	Taste transduction_Homo sapiens_hsa04742	0.36567131
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35761920
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34350622
87	Sulfur relay system_Homo sapiens_hsa04122	0.32830015
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32426395
89	Fatty acid degradation_Homo sapiens_hsa00071	0.32238289
90	Glutathione metabolism_Homo sapiens_hsa00480	0.29962057
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27171681
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26966181
93	Folate biosynthesis_Homo sapiens_hsa00790	0.26661087
94	Serotonergic synapse_Homo sapiens_hsa04726	0.26553835
95	Fatty acid elongation_Homo sapiens_hsa00062	0.25861406
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.24453996
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23160501
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22526382
99	African trypanosomiasis_Homo sapiens_hsa05143	0.22052808
100	Mineral absorption_Homo sapiens_hsa04978	0.19811498

RPS3AP12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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