ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand renaturation (GO:0000733)	4.89203987
2	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	4.68838815
3	positive regulation of guanylate cyclase activity (GO:0031284)	4.47770864
4	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	4.43700222
5	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	4.43700222
6	chromatin remodeling at centromere (GO:0031055)	4.16956702
7	regulation of guanylate cyclase activity (GO:0031282)	4.01364688
8	ubiquinone biosynthetic process (GO:0006744)	3.85223483
9	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.84708312
10	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.78214304
11	isotype switching (GO:0045190)	3.78214304
12	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.78214304
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.70565207
14	negative regulation of telomere maintenance (GO:0032205)	3.68397933
15	positive regulation of prostaglandin secretion (GO:0032308)	3.65849236
16	ubiquinone metabolic process (GO:0006743)	3.64007950
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.54171017
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.54171017
19	CENP-A containing nucleosome assembly (GO:0034080)	3.52920620
20	positive regulation of cGMP biosynthetic process (GO:0030828)	3.51447310
21	mast cell activation involved in immune response (GO:0002279)	3.50845372
22	mast cell degranulation (GO:0043303)	3.50845372
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.47720756
24	kinetochore assembly (GO:0051382)	3.44630324
25	behavioral response to nicotine (GO:0035095)	3.43724328
26	short-chain fatty acid metabolic process (GO:0046459)	3.40497888
27	drug catabolic process (GO:0042737)	3.39928696
28	response to pheromone (GO:0019236)	3.37429166
29	head development (GO:0060322)	3.32480292
30	intraciliary transport (GO:0042073)	3.29032706
31	regulation of cGMP biosynthetic process (GO:0030826)	3.27207806
32	negative regulation of meiosis (GO:0045835)	3.18526399
33	regulation of prostaglandin secretion (GO:0032306)	3.17292074
34	basic amino acid transport (GO:0015802)	3.15774831
35	quinone biosynthetic process (GO:1901663)	3.07572110
36	negative regulation of metanephros development (GO:0072217)	3.06302351
37	nonmotile primary cilium assembly (GO:0035058)	3.05850747
38	positive regulation of cGMP metabolic process (GO:0030825)	3.05476841
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.03365870
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.03365870
41	NADH dehydrogenase complex assembly (GO:0010257)	3.03365870
42	histone exchange (GO:0043486)	2.98926978
43	protein neddylation (GO:0045116)	2.98138354
44	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.95802934
45	lysosome localization (GO:0032418)	2.94626114
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94284894
47	base-excision repair, AP site formation (GO:0006285)	2.93038680
48	regulation of cGMP metabolic process (GO:0030823)	2.92511287
49	maturation of 5.8S rRNA (GO:0000460)	2.88298047
50	DNA deamination (GO:0045006)	2.87477257
51	kinetochore organization (GO:0051383)	2.86542683
52	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.81707809
53	pseudouridine synthesis (GO:0001522)	2.80772850
54	somatic diversification of immunoglobulins (GO:0016445)	2.78944065
55	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.78926148
56	regulation of mitotic spindle checkpoint (GO:1903504)	2.78926148
57	auditory receptor cell differentiation (GO:0042491)	2.78841955
58	inner ear receptor cell development (GO:0060119)	2.78391633
59	axonemal dynein complex assembly (GO:0070286)	2.77396659
60	regulation of cellular respiration (GO:0043457)	2.76429264
61	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.76149216
62	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.75933332
63	glyoxylate metabolic process (GO:0046487)	2.75820392
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.75271805
65	ribosomal small subunit assembly (GO:0000028)	2.75240096
66	sodium-independent organic anion transport (GO:0043252)	2.75114964
67	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.74913950
68	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.74913950
69	cullin deneddylation (GO:0010388)	2.73124008
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.72221459
71	rhodopsin mediated signaling pathway (GO:0016056)	2.72033884
72	isoprenoid biosynthetic process (GO:0008299)	2.71543780
73	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	2.71151529
74	protein localization to cilium (GO:0061512)	2.70758854
75	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	2.69303279
76	protein complex biogenesis (GO:0070271)	2.69005403
77	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66220213
78	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.65833837
79	glycosphingolipid biosynthetic process (GO:0006688)	2.64314321
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62016689
81	DNA demethylation (GO:0080111)	2.61559621
82	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.61428085
83	platelet dense granule organization (GO:0060155)	2.60873672
84	reciprocal DNA recombination (GO:0035825)	2.60811720
85	reciprocal meiotic recombination (GO:0007131)	2.60811720
86	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.60102264
87	DNA replication-independent nucleosome organization (GO:0034724)	2.57413828
88	DNA replication-independent nucleosome assembly (GO:0006336)	2.57413828
89	replication fork processing (GO:0031297)	2.55862184
90	protein-cofactor linkage (GO:0018065)	2.54902393
91	positive regulation of protein homooligomerization (GO:0032464)	2.53093897
92	heterochromatin organization (GO:0070828)	2.52963895
93	purine nucleobase biosynthetic process (GO:0009113)	2.52840764
94	DNA catabolic process, exonucleolytic (GO:0000738)	2.52678341
95	regulation of cilium movement (GO:0003352)	2.51639062
96	resolution of meiotic recombination intermediates (GO:0000712)	2.51484667
97	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.50970752
98	negative regulation of meiotic cell cycle (GO:0051447)	2.50499769
99	DNA double-strand break processing (GO:0000729)	2.49724186
100	secondary metabolite biosynthetic process (GO:0044550)	2.47561555

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.64881893
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.39682451
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.33833028
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.15181334
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10321162
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.96600021
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.92861662
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.87538740
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.42303820
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.37505841
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24288854
12	FUS_26573619_Chip-Seq_HEK293_Human	2.11375090
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06107278
14	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.05724796
15	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.91630369
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90532365
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.86978923
18	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.86098910
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.84060223
20	P300_19829295_ChIP-Seq_ESCs_Human	1.80388503
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80317984
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.76802651
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74124229
24	VDR_22108803_ChIP-Seq_LS180_Human	1.74064881
25	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67501797
26	EWS_26573619_Chip-Seq_HEK293_Human	1.67391095
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59951199
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58060608
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56791499
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.56269350
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55005281
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53469670
33	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.49779825
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46917044
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.45026187
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43592436
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43274126
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.43274126
39	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.42162124
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39093170
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35631378
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33066415
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.31976090
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.29534349
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.28855469
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28855219
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27409546
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22012366
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21705683
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19979255
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15912096
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15671085
53	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12147671
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11444381
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09697365
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09604393
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09523655
58	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08928903
59	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06898267
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.06387164
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05916738
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05916738
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.05816904
64	VDR_23849224_ChIP-Seq_CD4+_Human	1.05496397
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04771446
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00963771
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00061299
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99893981
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.99627189
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98688583
71	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98380494
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98120081
73	NCOR_22424771_ChIP-Seq_293T_Human	0.98109196
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97621061
75	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97574716
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97194681
77	PHF8_20622853_ChIP-Seq_HELA_Human	0.96560088
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95751326
79	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95496084
80	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95443593
81	TCF4_23295773_ChIP-Seq_U87_Human	0.95057033
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94176233
83	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94012362
84	NFYB_21822215_ChIP-Seq_K562_Human	0.92859804
85	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92120153
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.89676058
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.89462593
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.89102152
89	TAF15_26573619_Chip-Seq_HEK293_Human	0.87982384
90	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87706430
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.87565889
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.87240592
93	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.86617800
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.85333539
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84376034
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.84137774
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.84019235
98	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.83954117
99	STAT3_23295773_ChIP-Seq_U87_Human	0.83186904
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.83081926

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.84907639
2	MP0006292_abnormal_olfactory_placode	3.28920467
3	MP0005174_abnormal_tail_pigmentation	2.85150947
4	MP0002138_abnormal_hepatobiliary_system	2.83943123
5	MP0001968_abnormal_touch/_nociception	2.67942520
6	MP0003890_abnormal_embryonic-extraembry	2.65067767
7	MP0002163_abnormal_gland_morphology	2.51202934
8	MP0001188_hyperpigmentation	2.46277545
9	MP0002876_abnormal_thyroid_physiology	2.31595439
10	MP0002102_abnormal_ear_morphology	2.19228891
11	MP0002736_abnormal_nociception_after	2.18327452
12	MP0003122_maternal_imprinting	2.05584838
13	MP0000015_abnormal_ear_pigmentation	2.02910448
14	MP0001293_anophthalmia	1.97951305
15	MP0005084_abnormal_gallbladder_morpholo	1.97296719
16	MP0008058_abnormal_DNA_repair	1.87720074
17	MP0008875_abnormal_xenobiotic_pharmacok	1.85566092
18	MP0003880_abnormal_central_pattern	1.82262033
19	MP0000372_irregular_coat_pigmentation	1.82029836
20	MP0008872_abnormal_physiological_respon	1.78508409
21	MP0005377_hearing/vestibular/ear_phenot	1.78003721
22	MP0003878_abnormal_ear_physiology	1.78003721
23	MP0001348_abnormal_lacrimal_gland	1.77159978
24	MP0003121_genomic_imprinting	1.75671339
25	MP0008877_abnormal_DNA_methylation	1.75318061
26	MP0003646_muscle_fatigue	1.70660224
27	MP0002938_white_spotting	1.65316502
28	MP0002234_abnormal_pharynx_morphology	1.64900774
29	MP0003123_paternal_imprinting	1.64728294
30	MP0002638_abnormal_pupillary_reflex	1.59001429
31	MP0002277_abnormal_respiratory_mucosa	1.57177620
32	MP0002095_abnormal_skin_pigmentation	1.56669132
33	MP0005394_taste/olfaction_phenotype	1.56013603
34	MP0005499_abnormal_olfactory_system	1.56013603
35	MP0006054_spinal_hemorrhage	1.54781237
36	MP0005551_abnormal_eye_electrophysiolog	1.43862994
37	MP0003718_maternal_effect	1.39949625
38	MP0006276_abnormal_autonomic_nervous	1.39791102
39	MP0000647_abnormal_sebaceous_gland	1.38976848
40	MP0004885_abnormal_endolymph	1.36759239
41	MP0003186_abnormal_redox_activity	1.34782717
42	MP0000569_abnormal_digit_pigmentation	1.32059748
43	MP0002160_abnormal_reproductive_system	1.28805842
44	MP0009379_abnormal_foot_pigmentation	1.25620299
45	MP0003195_calcinosis	1.25175302
46	MP0000778_abnormal_nervous_system	1.24981889
47	MP0005379_endocrine/exocrine_gland_phen	1.24521903
48	MP0008789_abnormal_olfactory_epithelium	1.23899323
49	MP0005075_abnormal_melanosome_morpholog	1.21636631
50	MP0008775_abnormal_heart_ventricle	1.18422026
51	MP0001485_abnormal_pinna_reflex	1.14412489
52	MP0010094_abnormal_chromosome_stability	1.14133870
53	MP0002254_reproductive_system_inflammat	1.10727754
54	MP0004133_heterotaxia	1.10234101
55	MP0001970_abnormal_pain_threshold	1.08373435
56	MP0002272_abnormal_nervous_system	1.05639499
57	MP0009046_muscle_twitch	1.02467094
58	MP0005195_abnormal_posterior_eye	1.01168372
59	MP0004142_abnormal_muscle_tone	1.00223390
60	MP0005167_abnormal_blood-brain_barrier	0.99210885
61	MP0003638_abnormal_response/metabolism_	0.98218544
62	MP0009745_abnormal_behavioral_response	0.96164013
63	MP0000631_abnormal_neuroendocrine_gland	0.95842358
64	MP0002733_abnormal_thermal_nociception	0.95782172
65	MP0002089_abnormal_postnatal_growth/wei	0.94483093
66	MP0003786_premature_aging	0.93980483
67	MP0003252_abnormal_bile_duct	0.93808264
68	MP0008995_early_reproductive_senescence	0.93686899
69	MP0004381_abnormal_hair_follicle	0.92694563
70	MP0001346_abnormal_lacrimal_gland	0.91242614
71	MP0001727_abnormal_embryo_implantation	0.89082955
72	MP0001756_abnormal_urination	0.88435313
73	MP0005410_abnormal_fertilization	0.88226534
74	MP0004233_abnormal_muscle_weight	0.88016701
75	MP0003787_abnormal_imprinting	0.87920216
76	MP0004147_increased_porphyrin_level	0.87686445
77	MP0001286_abnormal_eye_development	0.87350165
78	MP0005423_abnormal_somatic_nervous	0.86559731
79	MP0001270_distended_abdomen	0.86229923
80	MP0002210_abnormal_sex_determination	0.84719884
81	MP0002067_abnormal_sensory_capabilities	0.84034644
82	MP0002734_abnormal_mechanical_nocicepti	0.83247140
83	MP0000427_abnormal_hair_cycle	0.83180319
84	MP0002572_abnormal_emotion/affect_behav	0.82815794
85	MP0004924_abnormal_behavior	0.77996978
86	MP0005386_behavior/neurological_phenoty	0.77996978
87	MP0000026_abnormal_inner_ear	0.77798950
88	MP0001984_abnormal_olfaction	0.77601899
89	MP0002837_dystrophic_cardiac_calcinosis	0.77329871
90	MP0002752_abnormal_somatic_nervous	0.76533171
91	MP0006035_abnormal_mitochondrial_morpho	0.74143331
92	MP0004145_abnormal_muscle_electrophysio	0.73527315
93	MP0001929_abnormal_gametogenesis	0.73492031
94	MP0006082_CNS_inflammation	0.73436621
95	MP0002233_abnormal_nose_morphology	0.73175759
96	MP0002653_abnormal_ependyma_morphology	0.72076937
97	MP0005409_darkened_coat_color	0.71847361
98	MP0002063_abnormal_learning/memory/cond	0.70672646
99	MP0000955_abnormal_spinal_cord	0.69786220
100	MP0002184_abnormal_innervation	0.69640178

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	3.86459579
2	Pancreatic fibrosis (HP:0100732)	3.68441371
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.44516511
4	Severe visual impairment (HP:0001141)	3.42940545
5	Pancreatic cysts (HP:0001737)	3.38470615
6	Abnormality of midbrain morphology (HP:0002418)	3.26144464
7	Molar tooth sign on MRI (HP:0002419)	3.26144464
8	Abnormality of the fovea (HP:0000493)	3.24599830
9	Abnormality of the renal medulla (HP:0100957)	3.20669241
10	Type II lissencephaly (HP:0007260)	3.12793664
11	Scotoma (HP:0000575)	3.09099540
12	Cerebellar dysplasia (HP:0007033)	3.05378665
13	Abnormal drinking behavior (HP:0030082)	2.94733421
14	Polydipsia (HP:0001959)	2.94733421
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.92606103
16	Reticulocytopenia (HP:0001896)	2.89295312
17	True hermaphroditism (HP:0010459)	2.85358836
18	Abnormality of macular pigmentation (HP:0008002)	2.81823156
19	Hypoplasia of the pons (HP:0012110)	2.76073596
20	Acute encephalopathy (HP:0006846)	2.74640097
21	Colon cancer (HP:0003003)	2.74288644
22	Acute necrotizing encephalopathy (HP:0006965)	2.70370545
23	Congenital stationary night blindness (HP:0007642)	2.68970046
24	Abnormality of the pons (HP:0007361)	2.67479609
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56711112
26	Bile duct proliferation (HP:0001408)	2.56321095
27	Abnormal biliary tract physiology (HP:0012439)	2.56321095
28	Chronic bronchitis (HP:0004469)	2.55573128
29	Abnormality of the labia minora (HP:0012880)	2.50412373
30	Abolished electroretinogram (ERG) (HP:0000550)	2.49960120
31	Mitochondrial inheritance (HP:0001427)	2.48524935
32	Septo-optic dysplasia (HP:0100842)	2.48234927
33	Absent/shortened dynein arms (HP:0200106)	2.39896896
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39896896
35	Lissencephaly (HP:0001339)	2.37751934
36	Abnormality of chromosome stability (HP:0003220)	2.37006564
37	Sclerocornea (HP:0000647)	2.36053093
38	Cystic liver disease (HP:0006706)	2.35075261
39	Medial flaring of the eyebrow (HP:0010747)	2.34036851
40	Polyuria (HP:0000103)	2.32913620
41	Cerebral palsy (HP:0100021)	2.32497000
42	Asplenia (HP:0001746)	2.31001784
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.29685704
44	Shawl scrotum (HP:0000049)	2.27632962
45	Abnormality of the nasal septum (HP:0000419)	2.25220556
46	Attenuation of retinal blood vessels (HP:0007843)	2.23916151
47	Tetany (HP:0001281)	2.23496989
48	Abnormal mitochondria in muscle tissue (HP:0008316)	2.23241318
49	Hyperglycinemia (HP:0002154)	2.22328748
50	Central scotoma (HP:0000603)	2.21013825
51	Gonadotropin excess (HP:0000837)	2.20215597
52	Volvulus (HP:0002580)	2.17557658
53	Optic disc pallor (HP:0000543)	2.15384653
54	Increased IgM level (HP:0003496)	2.13448548
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10654116
56	Stenosis of the external auditory canal (HP:0000402)	2.09547777
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.07494708
58	Hypoplasia of the fovea (HP:0007750)	2.07494708
59	Abnormal respiratory motile cilium physiology (HP:0012261)	2.07031872
60	Progressive macrocephaly (HP:0004481)	2.07023486
61	Clubbing of toes (HP:0100760)	2.05949112
62	Hypomagnesemia (HP:0002917)	2.03167053
63	Optic nerve hypoplasia (HP:0000609)	2.00805092
64	Nephrogenic diabetes insipidus (HP:0009806)	1.99132006
65	Abnormality of the ileum (HP:0001549)	1.96666070
66	Tubular atrophy (HP:0000092)	1.93692687
67	Increased circulating renin level (HP:0000848)	1.92793563
68	Anencephaly (HP:0002323)	1.92382786
69	Abnormal hair whorl (HP:0010721)	1.91926126
70	Hypokalemic alkalosis (HP:0001949)	1.91864013
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89928093
72	Hyperglycinuria (HP:0003108)	1.89517018
73	Decreased central vision (HP:0007663)	1.88250568
74	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.87511028
75	Polyphagia (HP:0002591)	1.87471678
76	Absent thumb (HP:0009777)	1.87105123
77	Chromsome breakage (HP:0040012)	1.86187090
78	Abnormal pancreas size (HP:0012094)	1.85841910
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.83750484
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83750484
81	Abnormality of the renal collecting system (HP:0004742)	1.83046944
82	Prostate neoplasm (HP:0100787)	1.82488824
83	Congenital, generalized hypertrichosis (HP:0004540)	1.82244081
84	High anterior hairline (HP:0009890)	1.81291715
85	Meckel diverticulum (HP:0002245)	1.80108100
86	Poor coordination (HP:0002370)	1.79893475
87	Progressive muscle weakness (HP:0003323)	1.78734849
88	Abnormal urine output (HP:0012590)	1.77362599
89	Increased CSF lactate (HP:0002490)	1.76739498
90	Abnormal ciliary motility (HP:0012262)	1.76684685
91	Adrenal hypoplasia (HP:0000835)	1.74949100
92	Cerebral edema (HP:0002181)	1.73879678
93	Rhinitis (HP:0012384)	1.72820886
94	Dandy-Walker malformation (HP:0001305)	1.72575465
95	Abnormality of DNA repair (HP:0003254)	1.72544655
96	Duplicated collecting system (HP:0000081)	1.72101161
97	Gait imbalance (HP:0002141)	1.70403158
98	Abnormality of renin-angiotensin system (HP:0000847)	1.69640829
99	Hepatocellular necrosis (HP:0001404)	1.68996717
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68261427

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.92212772
2	STK39	4.44677735
3	BCKDK	3.65193232
4	OXSR1	3.26347876
5	TRIM28	3.21380518
6	VRK2	2.68473829
7	TNIK	2.62921584
8	BCR	2.60176387
9	PNCK	2.49210099
10	TAF1	2.43453353
11	WEE1	2.15536724
12	NME1	2.11231051
13	BUB1	1.91735103
14	ADRBK2	1.91218181
15	NUAK1	1.81444472
16	BMPR1B	1.80401166
17	LMTK2	1.63577651
18	MKNK2	1.63062499
19	EPHA4	1.43225671
20	PINK1	1.42103199
21	MAP3K4	1.42033398
22	ZAK	1.41508429
23	DYRK2	1.36991331
24	VRK1	1.34710552
25	NEK1	1.32600610
26	FRK	1.31084127
27	PLK4	1.30345284
28	GRK1	1.29610154
29	MAP2K7	1.26127421
30	MARK1	1.25284913
31	TLK1	1.16147103
32	PRKCG	1.15613666
33	PIK3CA	1.10851803
34	MKNK1	1.08244037
35	STK16	1.06362793
36	WNK3	1.04452334
37	CDK19	0.96373526
38	CDC7	0.95459675
39	PBK	0.94871934
40	PLK2	0.93296676
41	CSNK1G2	0.88281905
42	MAPK13	0.88003115
43	STK3	0.82908872
44	ERBB3	0.82324607
45	CSNK1G3	0.79608829
46	DYRK1A	0.79243811
47	MAP4K2	0.79001650
48	CASK	0.78542317
49	PRKCQ	0.75524611
50	NEK2	0.74718627
51	EPHB2	0.72114476
52	CAMKK2	0.69431642
53	TAOK3	0.66407172
54	PLK3	0.66078223
55	PLK1	0.63956262
56	PRKG2	0.62072239
57	DAPK2	0.61490820
58	INSRR	0.60652534
59	FGFR1	0.60521001
60	PHKG2	0.54939040
61	PHKG1	0.54939040
62	DMPK	0.52483201
63	MAP2K6	0.52472192
64	CSNK1G1	0.52363988
65	NTRK3	0.50300351
66	ADRBK1	0.49319526
67	PRKCE	0.47935014
68	MAP3K12	0.46833679
69	CDK18	0.46711496
70	MET	0.46319009
71	CDK15	0.46133502
72	AURKB	0.46069098
73	CDK11A	0.45976719
74	CAMK1	0.44953855
75	CAMK1G	0.44812822
76	CAMK2A	0.44442795
77	ACVR1B	0.44338152
78	CDK14	0.43853254
79	ERBB2	0.43114183
80	CSNK1A1L	0.42561972
81	MAP3K10	0.41797705
82	ATM	0.41324699
83	DYRK3	0.41246975
84	TIE1	0.41237408
85	ATR	0.40119900
86	CAMK2D	0.38273113
87	PAK3	0.36033731
88	DYRK1B	0.35932551
89	MAPKAPK5	0.35599416
90	NTRK2	0.34577153
91	PRKCA	0.32634836
92	CSNK2A2	0.31880927
93	DAPK3	0.30631892
94	TXK	0.29391945
95	CAMK1D	0.29008900
96	PTK2B	0.28933929
97	TGFBR1	0.27463740
98	MELK	0.27008769
99	CSNK1A1	0.27004922
100	CSNK2A1	0.26436572

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	2.88616931
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.76161007
3	Phototransduction_Homo sapiens_hsa04744	2.75334477
4	Butanoate metabolism_Homo sapiens_hsa00650	2.60318414
5	Homologous recombination_Homo sapiens_hsa03440	2.59281262
6	RNA polymerase_Homo sapiens_hsa03020	2.55098420
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.52636910
8	Basal transcription factors_Homo sapiens_hsa03022	2.41104947
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.40760731
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.40758878
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.20658416
12	Nicotine addiction_Homo sapiens_hsa05033	2.12343944
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02324575
14	Proteasome_Homo sapiens_hsa03050	1.99546661
15	Parkinsons disease_Homo sapiens_hsa05012	1.99081347
16	Huntingtons disease_Homo sapiens_hsa05016	1.79717348
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77507191
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.76811220
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.73223809
20	Propanoate metabolism_Homo sapiens_hsa00640	1.69103941
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.65950588
22	RNA degradation_Homo sapiens_hsa03018	1.61462647
23	Protein export_Homo sapiens_hsa03060	1.56162732
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53708400
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.52305963
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.50641643
27	Base excision repair_Homo sapiens_hsa03410	1.47601949
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44105518
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43503883
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.38521842
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33873685
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31029048
33	Olfactory transduction_Homo sapiens_hsa04740	1.28545701
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.27287725
35	Alzheimers disease_Homo sapiens_hsa05010	1.23859410
36	Sulfur relay system_Homo sapiens_hsa04122	1.22814163
37	Mismatch repair_Homo sapiens_hsa03430	1.22076042
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19312324
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18895686
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17494566
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17256335
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.11580959
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.09170303
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04646354
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01355872
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.01202202
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98459835
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97007088
49	Peroxisome_Homo sapiens_hsa04146	0.93963258
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93892180
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93679589
52	One carbon pool by folate_Homo sapiens_hsa00670	0.88865315
53	Purine metabolism_Homo sapiens_hsa00230	0.83946930
54	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.83132638
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78469591
56	Retinol metabolism_Homo sapiens_hsa00830	0.77138998
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76565781
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76563268
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75931465
60	Metabolic pathways_Homo sapiens_hsa01100	0.75372202
61	Morphine addiction_Homo sapiens_hsa05032	0.74069879
62	Asthma_Homo sapiens_hsa05310	0.72691901
63	RNA transport_Homo sapiens_hsa03013	0.70239943
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70092526
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69146100
66	Caffeine metabolism_Homo sapiens_hsa00232	0.66801355
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65493654
68	Taste transduction_Homo sapiens_hsa04742	0.61589744
69	Spliceosome_Homo sapiens_hsa03040	0.61388641
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.60238744
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.59730796
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59152597
73	DNA replication_Homo sapiens_hsa03030	0.59073587
74	Regulation of autophagy_Homo sapiens_hsa04140	0.57939532
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57925426
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.57694734
77	Bile secretion_Homo sapiens_hsa04976	0.57374917
78	Allograft rejection_Homo sapiens_hsa05330	0.55319267
79	African trypanosomiasis_Homo sapiens_hsa05143	0.52271213
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.52106801
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50446677
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48593784
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.48230574
84	GABAergic synapse_Homo sapiens_hsa04727	0.48220855
85	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.47887798
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.45643971
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44511849
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44335897
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41316039
90	Galactose metabolism_Homo sapiens_hsa00052	0.41294041
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.40811487
92	Serotonergic synapse_Homo sapiens_hsa04726	0.40391956
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.37645486
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36645115
95	Insulin secretion_Homo sapiens_hsa04911	0.35735991
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30796669
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30227734
98	Circadian entrainment_Homo sapiens_hsa04713	0.29710555
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29398457
100	Pancreatic secretion_Homo sapiens_hsa04972	0.29074910

RPS3AP14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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