RPS3AP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.69862200
2piRNA metabolic process (GO:0034587)5.93313135
3response to pheromone (GO:0019236)5.88786936
4nephron tubule morphogenesis (GO:0072078)5.21220322
5nephron epithelium morphogenesis (GO:0072088)5.21220322
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.82733437
7nonmotile primary cilium assembly (GO:0035058)4.58735695
8DNA methylation involved in gamete generation (GO:0043046)4.56527935
9epithelial cilium movement (GO:0003351)4.52832711
10organelle disassembly (GO:1903008)4.30498788
11axonemal dynein complex assembly (GO:0070286)4.23508091
12axoneme assembly (GO:0035082)4.18630558
13cilium movement (GO:0003341)4.17905687
14endoderm formation (GO:0001706)4.00810099
15regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.97995990
16regulation of cilium movement (GO:0003352)3.90289485
17renal tubule morphogenesis (GO:0061333)3.79010488
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.78206998
19positive regulation of growth hormone secretion (GO:0060124)3.77675563
20protein neddylation (GO:0045116)3.76581418
21left/right axis specification (GO:0070986)3.72826677
22inner ear receptor stereocilium organization (GO:0060122)3.71887702
23ribonucleoprotein complex disassembly (GO:0032988)3.63052421
24regulation of mitotic spindle checkpoint (GO:1903504)3.61756194
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61756194
26tryptophan catabolic process (GO:0006569)3.60218554
27indole-containing compound catabolic process (GO:0042436)3.60218554
28indolalkylamine catabolic process (GO:0046218)3.60218554
29GPI anchor metabolic process (GO:0006505)3.58847777
30synaptic transmission, cholinergic (GO:0007271)3.58317370
31cilium or flagellum-dependent cell motility (GO:0001539)3.57789549
32type B pancreatic cell development (GO:0003323)3.56504653
33GPI anchor biosynthetic process (GO:0006506)3.52536381
34kynurenine metabolic process (GO:0070189)3.50535250
35brain morphogenesis (GO:0048854)3.46476856
36localization within membrane (GO:0051668)3.43433155
37inner ear receptor cell development (GO:0060119)3.32890537
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.32826725
39DNA deamination (GO:0045006)3.27339767
40regulation of germinal center formation (GO:0002634)3.26970706
41prostate gland growth (GO:0060736)3.26783400
42auditory receptor cell stereocilium organization (GO:0060088)3.25835845
43RNA destabilization (GO:0050779)3.25317963
44retinal cone cell development (GO:0046549)3.24509682
45regulation of mesoderm development (GO:2000380)3.23289913
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22781027
47preassembly of GPI anchor in ER membrane (GO:0016254)3.22473794
48regulation of memory T cell differentiation (GO:0043380)3.16491089
49left/right pattern formation (GO:0060972)3.14120405
50behavioral response to nicotine (GO:0035095)3.13387694
51kinetochore assembly (GO:0051382)3.10102507
52photoreceptor cell maintenance (GO:0045494)3.09365599
53detection of mechanical stimulus involved in sensory perception (GO:0050974)3.06663377
54cilium morphogenesis (GO:0060271)3.04241071
55spinal cord motor neuron differentiation (GO:0021522)3.03734960
56positive regulation of cell fate commitment (GO:0010455)3.01605233
57negative regulation of translation, ncRNA-mediated (GO:0040033)2.99917205
58regulation of translation, ncRNA-mediated (GO:0045974)2.99917205
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99917205
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99122884
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98290007
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98290007
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98095998
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.98095998
65NADH dehydrogenase complex assembly (GO:0010257)2.98095998
66platelet dense granule organization (GO:0060155)2.97584352
67positive regulation of oligodendrocyte differentiation (GO:0048714)2.97177520
68epithelial cell maturation (GO:0002070)2.96957407
69negative regulation of response to food (GO:0032096)2.94218204
70negative regulation of appetite (GO:0032099)2.94218204
71indolalkylamine metabolic process (GO:0006586)2.93234314
72regulation of growth hormone secretion (GO:0060123)2.92369589
73RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90343883
74spinal cord association neuron differentiation (GO:0021527)2.89869031
75protein localization to cilium (GO:0061512)2.85897961
76motile cilium assembly (GO:0044458)2.84637746
77tryptophan metabolic process (GO:0006568)2.84519685
78head development (GO:0060322)2.83307774
79intraciliary transport (GO:0042073)2.83101653
80neuronal action potential propagation (GO:0019227)2.82036948
81regulation of cell fate commitment (GO:0010453)2.78608161
82somite development (GO:0061053)2.76181460
83secondary heart field specification (GO:0003139)2.76034562
84heart field specification (GO:0003128)2.76034562
85dorsal/ventral neural tube patterning (GO:0021904)2.73431756
86dopamine transport (GO:0015872)2.73330010
87gene silencing by RNA (GO:0031047)2.70145936
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70006411
89ATP synthesis coupled proton transport (GO:0015986)2.70006411
90cellular biogenic amine catabolic process (GO:0042402)2.69215521
91amine catabolic process (GO:0009310)2.69215521
92mitochondrial respiratory chain complex assembly (GO:0033108)2.68926081
93neurofilament cytoskeleton organization (GO:0060052)2.66415909
94centriole replication (GO:0007099)2.66313761
95growth hormone secretion (GO:0030252)2.64911025
96pancreas development (GO:0031016)2.62683800
97forebrain neuron differentiation (GO:0021879)2.60147052
98protein complex biogenesis (GO:0070271)2.56884554
99cellular response to ammonium ion (GO:0071242)2.55551090
100determination of left/right symmetry (GO:0007368)2.52273097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.30746055
2EZH2_22144423_ChIP-Seq_EOC_Human2.85630025
3ZNF274_21170338_ChIP-Seq_K562_Hela2.78850157
4TAF15_26573619_Chip-Seq_HEK293_Human2.76073226
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70421005
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65126576
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59132979
8GBX2_23144817_ChIP-Seq_PC3_Human2.43235969
9EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.33904697
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32166469
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.28725783
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27938962
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27683924
14FUS_26573619_Chip-Seq_HEK293_Human2.26020208
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10233721
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06493292
17RNF2_27304074_Chip-Seq_NSC_Mouse2.06348209
18EWS_26573619_Chip-Seq_HEK293_Human2.06219474
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.04729190
20P300_19829295_ChIP-Seq_ESCs_Human2.01287517
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96376535
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77347592
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75746472
24ER_23166858_ChIP-Seq_MCF-7_Human1.75190596
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.71668517
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70834244
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68332118
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63153732
29IGF1R_20145208_ChIP-Seq_DFB_Human1.61507981
30AR_20517297_ChIP-Seq_VCAP_Human1.57960620
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.55459983
32ELK1_19687146_ChIP-ChIP_HELA_Human1.54304020
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.54196861
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52163062
35BCAT_22108803_ChIP-Seq_LS180_Human1.51951638
36MYC_18940864_ChIP-ChIP_HL60_Human1.51450543
37FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48684567
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46458332
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44042861
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44042861
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43011491
42CBP_20019798_ChIP-Seq_JUKART_Human1.43011491
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42350948
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40276297
45SOX2_19829295_ChIP-Seq_ESCs_Human1.38596705
46NANOG_19829295_ChIP-Seq_ESCs_Human1.38596705
47TP53_22573176_ChIP-Seq_HFKS_Human1.36826982
48FOXH1_21741376_ChIP-Seq_EPCs_Human1.35711455
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34551685
50CDX2_22108803_ChIP-Seq_LS180_Human1.33785617
51GATA3_26560356_Chip-Seq_TH2_Human1.33071724
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32157173
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31188672
54KDM2B_26808549_Chip-Seq_REH_Human1.31167101
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30279444
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29434908
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29329557
58AR_25329375_ChIP-Seq_VCAP_Human1.28304407
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28222963
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.28222963
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25976115
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.25649308
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.25526294
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.23942718
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22675864
66REST_21632747_ChIP-Seq_MESCs_Mouse1.21517555
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.20807810
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.18880032
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.18829822
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.16252303
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14648036
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12849053
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11912859
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11626388
75TCF4_22108803_ChIP-Seq_LS180_Human1.11019281
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09788879
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.09019234
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.08874655
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08756901
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08688267
81FOXP3_21729870_ChIP-Seq_TREG_Human1.08569792
82VDR_23849224_ChIP-Seq_CD4+_Human1.08430201
83SMAD4_21799915_ChIP-Seq_A2780_Human1.08096612
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.08089831
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07703763
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07640770
87TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07488761
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.07211612
89RXR_22108803_ChIP-Seq_LS180_Human1.06258431
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05523054
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05190999
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05082010
93P53_22387025_ChIP-Seq_ESCs_Mouse1.05007451
94RUNX2_22187159_ChIP-Seq_PCA_Human1.04699160
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03527643
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.03001710
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.02140951
98TCF4_23295773_ChIP-Seq_U87_Human1.01967755
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.01208607
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.99517179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.42719502
2MP0006072_abnormal_retinal_apoptosis3.36424308
3MP0002009_preneoplasia3.18209387
4MP0001984_abnormal_olfaction3.14898897
5MP0009697_abnormal_copulation3.02924685
6MP0004133_heterotaxia3.00450065
7MP0002102_abnormal_ear_morphology2.94704144
8MP0008875_abnormal_xenobiotic_pharmacok2.84616992
9MP0006292_abnormal_olfactory_placode2.53616947
10MP0004145_abnormal_muscle_electrophysio2.42666724
11MP0001835_abnormal_antigen_presentation2.41821175
12MP0002638_abnormal_pupillary_reflex2.41018464
13MP0005551_abnormal_eye_electrophysiolog2.20143623
14MP0002736_abnormal_nociception_after2.18903857
15MP0002138_abnormal_hepatobiliary_system2.16759273
16MP0003890_abnormal_embryonic-extraembry2.16481633
17MP0005253_abnormal_eye_physiology2.11138288
18MP0003195_calcinosis2.05274173
19MP0000372_irregular_coat_pigmentation2.03805111
20MP0004043_abnormal_pH_regulation1.99845144
21MP0003880_abnormal_central_pattern1.94562674
22MP0008789_abnormal_olfactory_epithelium1.92800019
23MP0005499_abnormal_olfactory_system1.92596084
24MP0005394_taste/olfaction_phenotype1.92596084
25MP0008877_abnormal_DNA_methylation1.88399981
26MP0001968_abnormal_touch/_nociception1.87588282
27MP0003787_abnormal_imprinting1.72347236
28MP0004142_abnormal_muscle_tone1.68177510
29MP0001905_abnormal_dopamine_level1.65503984
30MP0001293_anophthalmia1.61859837
31MP0002234_abnormal_pharynx_morphology1.58854697
32MP0002166_altered_tumor_susceptibility1.57392887
33MP0001986_abnormal_taste_sensitivity1.55629451
34MP0003878_abnormal_ear_physiology1.53625659
35MP0005377_hearing/vestibular/ear_phenot1.53625659
36MP0002735_abnormal_chemical_nociception1.50858929
37MP0003567_abnormal_fetal_cardiomyocyte1.50753579
38MP0004885_abnormal_endolymph1.45591264
39MP0003123_paternal_imprinting1.43751937
40MP0001501_abnormal_sleep_pattern1.34836656
41MP0001485_abnormal_pinna_reflex1.33699362
42MP0002653_abnormal_ependyma_morphology1.29137876
43MP0003119_abnormal_digestive_system1.29057837
44MP0005167_abnormal_blood-brain_barrier1.27466706
45MP0009379_abnormal_foot_pigmentation1.27242575
46MP0005195_abnormal_posterior_eye1.26898377
47MP0001486_abnormal_startle_reflex1.25544625
48MP0002272_abnormal_nervous_system1.20167211
49MP0001324_abnormal_eye_pigmentation1.19708626
50MP0005671_abnormal_response_to1.16518000
51MP0001286_abnormal_eye_development1.16203226
52MP0001440_abnormal_grooming_behavior1.15735748
53MP0000631_abnormal_neuroendocrine_gland1.13675659
54MP0002148_abnormal_hypersensitivity_rea1.13657291
55MP0003693_abnormal_embryo_hatching1.12961330
56MP0003937_abnormal_limbs/digits/tail_de1.12537119
57MP0009046_muscle_twitch1.12380234
58MP0001963_abnormal_hearing_physiology1.11230369
59MP0003718_maternal_effect1.08450645
60MP0008775_abnormal_heart_ventricle1.08132678
61MP0002006_tumorigenesis1.07958625
62MP0002752_abnormal_somatic_nervous1.04869599
63MP0002572_abnormal_emotion/affect_behav1.04624911
64MP0001727_abnormal_embryo_implantation1.02892964
65MP0000026_abnormal_inner_ear1.01663798
66MP0003136_yellow_coat_color0.99307375
67MP0008872_abnormal_physiological_respon0.97890954
68MP0002734_abnormal_mechanical_nocicepti0.97087228
69MP0005391_vision/eye_phenotype0.96814210
70MP0003646_muscle_fatigue0.93567877
71MP0009745_abnormal_behavioral_response0.92559693
72MP0002160_abnormal_reproductive_system0.90852236
73MP0003121_genomic_imprinting0.90805737
74MP0000778_abnormal_nervous_system0.90467852
75MP0001529_abnormal_vocalization0.87374829
76MP0001970_abnormal_pain_threshold0.87348484
77MP0005367_renal/urinary_system_phenotyp0.85212716
78MP0000516_abnormal_urinary_system0.85212716
79MP0002233_abnormal_nose_morphology0.84947473
80MP0002139_abnormal_hepatobiliary_system0.84370049
81MP0005646_abnormal_pituitary_gland0.83051802
82MP0002163_abnormal_gland_morphology0.82607536
83MP0006036_abnormal_mitochondrial_physio0.81713686
84MP0002067_abnormal_sensory_capabilities0.80521674
85MP0009764_decreased_sensitivity_to0.80481029
86MP0003698_abnormal_male_reproductive0.79381353
87MP0005386_behavior/neurological_phenoty0.78860953
88MP0004924_abnormal_behavior0.78860953
89MP0005075_abnormal_melanosome_morpholog0.78492253
90MP0000955_abnormal_spinal_cord0.77918095
91MP0005084_abnormal_gallbladder_morpholo0.77890121
92MP0001800_abnormal_humoral_immune0.77415399
93MP0004215_abnormal_myocardial_fiber0.76868972
94MP0002184_abnormal_innervation0.76817224
95MP0002277_abnormal_respiratory_mucosa0.73410354
96MP0002557_abnormal_social/conspecific_i0.73369582
97MP0005389_reproductive_system_phenotype0.70650925
98MP0004147_increased_porphyrin_level0.69599378
99MP0001929_abnormal_gametogenesis0.69361680
100MP0003283_abnormal_digestive_organ0.67311289

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.16194733
2Absent/shortened dynein arms (HP:0200106)4.91734211
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.91734211
4Methylmalonic acidemia (HP:0002912)4.13784284
5Chronic bronchitis (HP:0004469)3.89927121
6Congenital stationary night blindness (HP:0007642)3.72905825
7Abnormality of homocysteine metabolism (HP:0010919)3.49178258
8Homocystinuria (HP:0002156)3.49178258
9Pancreatic cysts (HP:0001737)3.43477287
10Neoplasm of the adrenal cortex (HP:0100641)3.39455924
11Abnormal respiratory motile cilium physiology (HP:0012261)3.37313910
12Acute necrotizing encephalopathy (HP:0006965)3.34159040
13Molar tooth sign on MRI (HP:0002419)3.29139765
14Abnormality of midbrain morphology (HP:0002418)3.29139765
15Pancreatic fibrosis (HP:0100732)3.19674654
16Methylmalonic aciduria (HP:0012120)3.18480123
17Progressive macrocephaly (HP:0004481)3.15865079
18Abnormal biliary tract physiology (HP:0012439)3.13344923
19Bile duct proliferation (HP:0001408)3.13344923
20Papilledema (HP:0001085)3.12587966
21True hermaphroditism (HP:0010459)3.04271185
22Abnormal respiratory epithelium morphology (HP:0012253)3.03633869
23Abnormal respiratory motile cilium morphology (HP:0005938)3.03633869
24Abolished electroretinogram (ERG) (HP:0000550)3.02132257
25Abnormal ciliary motility (HP:0012262)3.01835793
26Medial flaring of the eyebrow (HP:0010747)2.95713117
27Type 2 muscle fiber atrophy (HP:0003554)2.90446609
28Acute encephalopathy (HP:0006846)2.77597057
29Abnormal rod and cone electroretinograms (HP:0008323)2.75304742
30Rhinitis (HP:0012384)2.71848775
31Colon cancer (HP:0003003)2.69694634
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.69688310
33Decreased muscle mass (HP:0003199)2.67968354
34Abnormal mitochondria in muscle tissue (HP:0008316)2.67651090
35Pendular nystagmus (HP:0012043)2.60571225
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57553599
37Type II lissencephaly (HP:0007260)2.49802453
38Abnormality of vitamin B metabolism (HP:0004340)2.48532164
39Increased corneal curvature (HP:0100692)2.46601134
40Keratoconus (HP:0000563)2.46601134
41Abnormality of the renal medulla (HP:0100957)2.45776536
42Nephronophthisis (HP:0000090)2.45347889
43Facial diplegia (HP:0001349)2.44897654
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44824570
45Congenital, generalized hypertrichosis (HP:0004540)2.43380154
46Muscle fiber atrophy (HP:0100295)2.36241460
47Gonadotropin excess (HP:0000837)2.35379363
48Abnormality of methionine metabolism (HP:0010901)2.34310120
49Abnormality of the prostate (HP:0008775)2.32521476
50Anterior segment dysgenesis (HP:0007700)2.30486769
51Gait imbalance (HP:0002141)2.30442230
52Congenital primary aphakia (HP:0007707)2.29916902
53Supernumerary spleens (HP:0009799)2.29381973
54Nephrogenic diabetes insipidus (HP:0009806)2.27331493
55Adrenal hypoplasia (HP:0000835)2.25968573
56Cystic liver disease (HP:0006706)2.24642876
57Mitochondrial inheritance (HP:0001427)2.21864625
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16394222
59Tubulointerstitial nephritis (HP:0001970)2.16085892
60Hyperkalemia (HP:0002153)2.14027256
61Dyschromatopsia (HP:0007641)2.12791211
62Chorioretinal atrophy (HP:0000533)2.11344721
63Sclerocornea (HP:0000647)2.09889651
64Central scotoma (HP:0000603)2.09573423
65Muscle hypertrophy of the lower extremities (HP:0008968)2.06352020
66Abnormal pancreas size (HP:0012094)2.06278261
67Male pseudohermaphroditism (HP:0000037)2.01996592
68Testicular atrophy (HP:0000029)2.01731574
69Median cleft lip (HP:0000161)2.00516475
70Genital tract atresia (HP:0001827)1.98834270
71Increased CSF lactate (HP:0002490)1.96992292
72Elevated erythrocyte sedimentation rate (HP:0003565)1.96803592
733-Methylglutaconic aciduria (HP:0003535)1.95396974
74Abnormality of cells of the erythroid lineage (HP:0012130)1.95321473
75Optic disc pallor (HP:0000543)1.94696379
76Abnormal number of erythroid precursors (HP:0012131)1.93736998
77Poor coordination (HP:0002370)1.93345317
78Septo-optic dysplasia (HP:0100842)1.91268494
79Megaloblastic anemia (HP:0001889)1.90866972
80Anencephaly (HP:0002323)1.89493170
81Vaginal atresia (HP:0000148)1.88900036
82Cerebellar dysplasia (HP:0007033)1.86276516
83Stenosis of the external auditory canal (HP:0000402)1.85444454
84Thyroid-stimulating hormone excess (HP:0002925)1.83043468
85Adactyly (HP:0009776)1.82635056
86Congenital hepatic fibrosis (HP:0002612)1.82328570
87Hypothermia (HP:0002045)1.82023729
88Cerebral edema (HP:0002181)1.82008858
89Enlarged epiphyses (HP:0010580)1.81558157
90Rectal fistula (HP:0100590)1.81538513
91Rectovaginal fistula (HP:0000143)1.81538513
92Myotonia (HP:0002486)1.79752163
93Optic nerve hypoplasia (HP:0000609)1.77513583
94Bifid tongue (HP:0010297)1.77258467
95Asplenia (HP:0001746)1.74611562
96Growth hormone deficiency (HP:0000824)1.74357386
97Abnormality of male internal genitalia (HP:0000022)1.74325829
98Neoplasm of the adrenal gland (HP:0100631)1.73201687
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.72369885
100Increased hepatocellular lipid droplets (HP:0006565)1.71484399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.61777390
2PINK13.53289251
3ZAK3.33894699
4TAF12.82313170
5MKNK12.64036761
6NUAK12.63802493
7WNK42.56663634
8TLK12.55750256
9ADRBK22.49771855
10ACVR1B2.44454832
11SCYL22.25024926
12TEC2.21507278
13MAPKAPK52.16819846
14TAOK11.98802723
15WNK31.86142234
16MKNK21.72593643
17MAPK131.72374518
18ITK1.65715823
19GRK11.55509559
20MAPKAPK31.46449357
21MAP3K41.44644374
22NEK21.42393945
23TNIK1.41500329
24DYRK21.38664708
25ERBB31.35468874
26CSNK1G21.34346976
27EIF2AK31.33719672
28CSNK1G31.26713241
29PLK31.24559113
30MAP4K11.24012707
31STK111.20258062
32MUSK1.19769473
33TRIM281.18021986
34CDK191.16625877
35CSNK1G11.14528667
36SYK1.10197903
37BTK1.09737576
38RPS6KA41.08743922
39PHKG21.08157015
40PHKG11.08157015
41CSF1R1.06816800
42VRK11.06106099
43TAOK31.00084040
44FLT30.95981383
45RPS6KA50.95131710
46VRK20.92126477
47FGFR20.89671350
48MAP4K20.85049999
49OXSR10.84135463
50SRPK10.83837109
51KIT0.83088023
52PTK2B0.82589655
53MARK20.78083610
54CAMKK20.78043783
55PRKCQ0.76683136
56PDK20.76152025
57TIE10.76071126
58IRAK30.73910572
59ERBB40.71873627
60LYN0.70669781
61BMPR1B0.69823235
62PRKCE0.69599192
63STK390.68591715
64MYLK0.65990787
65CHEK20.64652107
66DYRK1B0.64253994
67SIK30.60964506
68CSNK1A1L0.60711068
69PIK3CG0.58493602
70CAMK2A0.56142339
71ADRBK10.55393735
72NME10.53841076
73PRKACA0.50873709
74CDK30.50856561
75CASK0.49690218
76MARK30.49060550
77OBSCN0.48795369
78TTK0.48054725
79PRKG10.46293113
80EPHA40.46248281
81GRK60.46033783
82MINK10.42594024
83BRSK20.41913298
84ABL10.40034849
85INSRR0.39495476
86PRKCG0.39489450
87NEK60.38370178
88PRKCZ0.36882293
89PRKAA20.36678194
90PLK10.35995561
91MAP2K70.34606308
92CSNK1A10.33700990
93TNK20.33028721
94PRKG20.32224201
95PRKCA0.32192524
96IKBKB0.32007017
97CAMK10.31972715
98MAP2K20.31914088
99PRKACG0.31715027
100CAMKK10.30752754

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.98530830
2Protein export_Homo sapiens_hsa030603.88154700
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.29621384
4Ribosome_Homo sapiens_hsa030102.63035101
5Allograft rejection_Homo sapiens_hsa053302.54113828
6Autoimmune thyroid disease_Homo sapiens_hsa053202.50677886
7Phototransduction_Homo sapiens_hsa047442.49950619
8Graft-versus-host disease_Homo sapiens_hsa053322.43278432
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.36047320
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31947907
11Linoleic acid metabolism_Homo sapiens_hsa005912.03352745
12Type I diabetes mellitus_Homo sapiens_hsa049402.00188368
13Sulfur relay system_Homo sapiens_hsa041221.92273203
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80344722
15Regulation of autophagy_Homo sapiens_hsa041401.79440915
16RNA degradation_Homo sapiens_hsa030181.72012138
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68873508
18Propanoate metabolism_Homo sapiens_hsa006401.65662278
19Oxidative phosphorylation_Homo sapiens_hsa001901.65028033
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55178538
21Homologous recombination_Homo sapiens_hsa034401.49352763
22Parkinsons disease_Homo sapiens_hsa050121.48188817
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42804136
24Tryptophan metabolism_Homo sapiens_hsa003801.41661487
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40702611
26Nicotine addiction_Homo sapiens_hsa050331.37043660
27Staphylococcus aureus infection_Homo sapiens_hsa051501.35009674
28Proteasome_Homo sapiens_hsa030501.33315904
29Ether lipid metabolism_Homo sapiens_hsa005651.31243898
30Fanconi anemia pathway_Homo sapiens_hsa034601.31131836
31Rheumatoid arthritis_Homo sapiens_hsa053231.27879332
32RNA polymerase_Homo sapiens_hsa030201.27587193
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21955861
34Folate biosynthesis_Homo sapiens_hsa007901.17015985
35Arachidonic acid metabolism_Homo sapiens_hsa005901.15832140
36Antigen processing and presentation_Homo sapiens_hsa046121.09386668
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03887528
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02333204
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00844107
40Olfactory transduction_Homo sapiens_hsa047400.99950632
41Butanoate metabolism_Homo sapiens_hsa006500.99217666
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98772195
43Hematopoietic cell lineage_Homo sapiens_hsa046400.98178314
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.95937706
45Steroid biosynthesis_Homo sapiens_hsa001000.95157872
46Huntingtons disease_Homo sapiens_hsa050160.94724169
47Basal transcription factors_Homo sapiens_hsa030220.92439204
48Peroxisome_Homo sapiens_hsa041460.91671128
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.89556059
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87772415
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86736435
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84869438
53Ovarian steroidogenesis_Homo sapiens_hsa049130.82514833
54Systemic lupus erythematosus_Homo sapiens_hsa053220.80198204
55Chemical carcinogenesis_Homo sapiens_hsa052040.79306993
56Viral myocarditis_Homo sapiens_hsa054160.79111711
57Morphine addiction_Homo sapiens_hsa050320.78089248
58Fat digestion and absorption_Homo sapiens_hsa049750.74474923
59Starch and sucrose metabolism_Homo sapiens_hsa005000.74253050
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73569201
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.72844457
62Cardiac muscle contraction_Homo sapiens_hsa042600.72151709
63Caffeine metabolism_Homo sapiens_hsa002320.70700425
64Sulfur metabolism_Homo sapiens_hsa009200.70084220
65Serotonergic synapse_Homo sapiens_hsa047260.64275111
66Salivary secretion_Homo sapiens_hsa049700.63309849
67Glutamatergic synapse_Homo sapiens_hsa047240.62878621
68Purine metabolism_Homo sapiens_hsa002300.61872576
69Alzheimers disease_Homo sapiens_hsa050100.60998804
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57955996
71Primary immunodeficiency_Homo sapiens_hsa053400.56298117
72Retinol metabolism_Homo sapiens_hsa008300.55922047
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55399211
74Vitamin digestion and absorption_Homo sapiens_hsa049770.54493863
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54271213
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54090870
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53752814
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.47968824
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47912079
80Metabolic pathways_Homo sapiens_hsa011000.45322338
81Taste transduction_Homo sapiens_hsa047420.43636853
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43568196
83Pyruvate metabolism_Homo sapiens_hsa006200.42303122
84GABAergic synapse_Homo sapiens_hsa047270.39561478
85Pyrimidine metabolism_Homo sapiens_hsa002400.36359771
86Selenocompound metabolism_Homo sapiens_hsa004500.35647328
87One carbon pool by folate_Homo sapiens_hsa006700.35629339
88Glycerolipid metabolism_Homo sapiens_hsa005610.34559291
89Collecting duct acid secretion_Homo sapiens_hsa049660.34138471
90Nucleotide excision repair_Homo sapiens_hsa034200.32296447
91Calcium signaling pathway_Homo sapiens_hsa040200.31462700
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31435657
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31389902
94Circadian entrainment_Homo sapiens_hsa047130.30422394
95Basal cell carcinoma_Homo sapiens_hsa052170.30162837
96Platelet activation_Homo sapiens_hsa046110.29604712
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28992153
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.28924670
99RNA transport_Homo sapiens_hsa030130.27594211
100Dorso-ventral axis formation_Homo sapiens_hsa043200.27563977

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