ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	7.36098894
2	maturation of SSU-rRNA (GO:0030490)	7.16802667
3	cell wall macromolecule metabolic process (GO:0044036)	6.61166726
4	response to gravity (GO:0009629)	5.28833876
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.05927534
6	ATP synthesis coupled proton transport (GO:0015986)	5.05927534
7	viral transcription (GO:0019083)	4.97536313
8	translational termination (GO:0006415)	4.84811351
9	ribosomal small subunit biogenesis (GO:0042274)	4.83544959
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.49074115
11	ribosomal small subunit assembly (GO:0000028)	4.44892663
12	NADH dehydrogenase complex assembly (GO:0010257)	4.33338390
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.33338390
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.33338390
15	translational elongation (GO:0006414)	4.26151190
16	protein neddylation (GO:0045116)	4.21657312
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.20435162
18	protein complex biogenesis (GO:0070271)	4.14981572
19	cotranslational protein targeting to membrane (GO:0006613)	4.13238201
20	protein targeting to ER (GO:0045047)	4.08036255
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.03261853
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.90187827
23	protein localization to endoplasmic reticulum (GO:0070972)	3.89579006
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.89454335
25	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.88960620
26	aldehyde catabolic process (GO:0046185)	3.85523965
27	chaperone-mediated protein transport (GO:0072321)	3.84471568
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.76989197
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.74394404
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.74394404
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.69165795
32	ribosomal large subunit biogenesis (GO:0042273)	3.68814967
33	cellular protein complex disassembly (GO:0043624)	3.59008549
34	negative regulation of appetite (GO:0032099)	3.58816137
35	negative regulation of response to food (GO:0032096)	3.58816137
36	rRNA catabolic process (GO:0016075)	3.58198901
37	viral life cycle (GO:0019058)	3.57426768
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.52720601
39	cullin deneddylation (GO:0010388)	3.41857591
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.33923701
41	electron transport chain (GO:0022900)	3.32297435
42	respiratory electron transport chain (GO:0022904)	3.30532723
43	protein deneddylation (GO:0000338)	3.28507061
44	translational initiation (GO:0006413)	3.26954493
45	behavioral response to nicotine (GO:0035095)	3.23411989
46	DNA deamination (GO:0045006)	3.18959900
47	regulation of skeletal muscle contraction (GO:0014819)	3.17537304
48	resolution of meiotic recombination intermediates (GO:0000712)	3.14416843
49	translation (GO:0006412)	3.06483798
50	termination of RNA polymerase III transcription (GO:0006386)	2.96534519
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.96534519
52	protein complex disassembly (GO:0043241)	2.95665467
53	negative regulation of mast cell activation (GO:0033004)	2.94625918
54	regulation of cilium movement (GO:0003352)	2.91619367
55	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.90839829
56	cell proliferation in forebrain (GO:0021846)	2.90825367
57	macromolecular complex disassembly (GO:0032984)	2.90313936
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.89625948
59	protein K6-linked ubiquitination (GO:0085020)	2.89333934
60	skeletal muscle tissue regeneration (GO:0043403)	2.85843701
61	viral protein processing (GO:0019082)	2.80001202
62	cellular response to ATP (GO:0071318)	2.79992948
63	nonmotile primary cilium assembly (GO:0035058)	2.79312038
64	protein polyglutamylation (GO:0018095)	2.78585884
65	response to pheromone (GO:0019236)	2.76710437
66	ATP biosynthetic process (GO:0006754)	2.75170588
67	myoblast migration (GO:0051451)	2.73816541
68	negative regulation of T cell differentiation in thymus (GO:0033085)	2.73435843
69	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.72486155
70	mRNA catabolic process (GO:0006402)	2.71518108
71	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.71011173
72	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.70284631
73	protein targeting to membrane (GO:0006612)	2.69737852
74	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.68557829
75	proteasome assembly (GO:0043248)	2.68241651
76	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66241348
77	rRNA metabolic process (GO:0016072)	2.64852179
78	cellular response to exogenous dsRNA (GO:0071360)	2.63488871
79	endoderm formation (GO:0001706)	2.62783009
80	rRNA processing (GO:0006364)	2.61637682
81	regulation of feeding behavior (GO:0060259)	2.60918788
82	tRNA processing (GO:0008033)	2.60564589
83	hydrogen transport (GO:0006818)	2.59434532
84	proton transport (GO:0015992)	2.58811244
85	cellular ketone body metabolic process (GO:0046950)	2.58707134
86	hydrogen ion transmembrane transport (GO:1902600)	2.56964796
87	cellular component biogenesis (GO:0044085)	2.56482092
88	regulation of appetite (GO:0032098)	2.55879478
89	GTP biosynthetic process (GO:0006183)	2.54812433
90	mannosylation (GO:0097502)	2.54208054
91	replication fork processing (GO:0031297)	2.53826019
92	platelet dense granule organization (GO:0060155)	2.53783203
93	kynurenine metabolic process (GO:0070189)	2.53440325
94	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.48624772
95	indolalkylamine metabolic process (GO:0006586)	2.48193750
96	organelle disassembly (GO:1903008)	2.48137647
97	RNA catabolic process (GO:0006401)	2.47295489
98	piRNA metabolic process (GO:0034587)	2.47217767
99	ketone body metabolic process (GO:1902224)	2.46264702
100	RNA phosphodiester bond hydrolysis (GO:0090501)	2.45847075

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.29335726
2	VDR_22108803_ChIP-Seq_LS180_Human	4.63574077
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.45217272
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.30445274
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97695507
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.82246870
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61619690
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56960060
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.51655633
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50697028
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.40984990
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37560786
13	FUS_26573619_Chip-Seq_HEK293_Human	2.29258164
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.05787610
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96682327
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.96670843
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93940205
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91353251
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87764927
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85859514
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80093347
22	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.76377807
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74760989
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66720760
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64242713
26	EWS_26573619_Chip-Seq_HEK293_Human	1.58662950
27	AR_20517297_ChIP-Seq_VCAP_Human	1.58577694
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.56770501
29	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.51453117
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49859326
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47886006
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.47657517
33	P300_19829295_ChIP-Seq_ESCs_Human	1.45812925
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42756204
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41740882
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.41729778
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40461270
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38838005
39	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.34351721
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33653363
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33653363
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.31151790
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.29810879
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28932583
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28154707
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26696441
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.25667213
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23506459
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23506459
50	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.23387172
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23051560
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21988221
53	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.21487585
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20944789
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18356871
56	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.17891487
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16354546
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15579641
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15510388
60	NCOR_22424771_ChIP-Seq_293T_Human	1.15243784
61	GATA3_26560356_Chip-Seq_TH2_Human	1.15049741
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.13391094
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10921447
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10762644
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10283449
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.09801927
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06920156
68	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06828997
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06743534
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05939787
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05561026
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04893377
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04390739
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04095739
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03077633
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02518679
77	CIITA_25753668_ChIP-Seq_RAJI_Human	1.00964393
78	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99741843
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.97905603
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97905603
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97440439
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.97129136
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96132915
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96132915
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95467457
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93822433
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91730886
88	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91606378
89	ERA_21632823_ChIP-Seq_H3396_Human	0.91192203
90	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.89962289
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89392398
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88346140
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88308712
94	GATA3_26560356_Chip-Seq_TH1_Human	0.88040492
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.88019385
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87921963
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87205952
98	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.86913805
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86751863
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.86550895

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.48808499
2	MP0004145_abnormal_muscle_electrophysio	3.54222405
3	MP0006072_abnormal_retinal_apoptosis	3.21891619
4	MP0003806_abnormal_nucleotide_metabolis	2.66591522
5	MP0004142_abnormal_muscle_tone	2.56866509
6	MP0001968_abnormal_touch/_nociception	2.49896097
7	MP0005671_abnormal_response_to	2.31768338
8	MP0002837_dystrophic_cardiac_calcinosis	2.27273027
9	MP0006292_abnormal_olfactory_placode	2.26146731
10	MP0002736_abnormal_nociception_after	2.17985505
11	MP0004147_increased_porphyrin_level	2.17620476
12	MP0005551_abnormal_eye_electrophysiolog	2.09763390
13	MP0001986_abnormal_taste_sensitivity	2.04069622
14	MP0008872_abnormal_physiological_respon	2.00451444
15	MP0001835_abnormal_antigen_presentation	1.94420934
16	MP0003880_abnormal_central_pattern	1.83741682
17	MP0008875_abnormal_xenobiotic_pharmacok	1.82177580
18	MP0002163_abnormal_gland_morphology	1.78169482
19	MP0002234_abnormal_pharynx_morphology	1.74196693
20	MP0001485_abnormal_pinna_reflex	1.69406635
21	MP0005084_abnormal_gallbladder_morpholo	1.67290036
22	MP0003646_muscle_fatigue	1.62092101
23	MP0005646_abnormal_pituitary_gland	1.60064861
24	MP0006036_abnormal_mitochondrial_physio	1.56351434
25	MP0004885_abnormal_endolymph	1.55653838
26	MP0001486_abnormal_startle_reflex	1.54316508
27	MP0003787_abnormal_imprinting	1.54210121
28	MP0001905_abnormal_dopamine_level	1.53865272
29	MP0001984_abnormal_olfaction	1.46842421
30	MP0005253_abnormal_eye_physiology	1.42425567
31	MP0005083_abnormal_biliary_tract	1.38798487
32	MP0002095_abnormal_skin_pigmentation	1.30722764
33	MP0000372_irregular_coat_pigmentation	1.30687221
34	MP0008877_abnormal_DNA_methylation	1.30377221
35	MP0002272_abnormal_nervous_system	1.30203082
36	MP0001529_abnormal_vocalization	1.29664814
37	MP0005075_abnormal_melanosome_morpholog	1.26336545
38	MP0008789_abnormal_olfactory_epithelium	1.20981866
39	MP0009745_abnormal_behavioral_response	1.20838383
40	MP0005389_reproductive_system_phenotype	1.18944226
41	MP0003567_abnormal_fetal_cardiomyocyte	1.16400568
42	MP0008775_abnormal_heart_ventricle	1.16178289
43	MP0002876_abnormal_thyroid_physiology	1.14144931
44	MP0003724_increased_susceptibility_to	1.12412818
45	MP0000516_abnormal_urinary_system	1.10816546
46	MP0005367_renal/urinary_system_phenotyp	1.10816546
47	MP0002160_abnormal_reproductive_system	1.07902452
48	MP0005645_abnormal_hypothalamus_physiol	1.07854422
49	MP0002938_white_spotting	1.07603686
50	MP0003186_abnormal_redox_activity	1.05330289
51	MP0003252_abnormal_bile_duct	1.04309900
52	MP0001800_abnormal_humoral_immune	1.03041612
53	MP0002138_abnormal_hepatobiliary_system	1.02414317
54	MP0006276_abnormal_autonomic_nervous	1.01968175
55	MP0009764_decreased_sensitivity_to	1.00091084
56	MP0003195_calcinosis	1.00019033
57	MP0001765_abnormal_ion_homeostasis	0.98617174
58	MP0005377_hearing/vestibular/ear_phenot	0.98194360
59	MP0003878_abnormal_ear_physiology	0.98194360
60	MP0002572_abnormal_emotion/affect_behav	0.97858464
61	MP0001440_abnormal_grooming_behavior	0.97839232
62	MP0005670_abnormal_white_adipose	0.96968671
63	MP0001970_abnormal_pain_threshold	0.96448429
64	MP0005195_abnormal_posterior_eye	0.95766326
65	MP0000427_abnormal_hair_cycle	0.95551144
66	MP0001919_abnormal_reproductive_system	0.95424571
67	MP0002102_abnormal_ear_morphology	0.94018074
68	MP0002723_abnormal_immune_serum	0.91597316
69	MP0005379_endocrine/exocrine_gland_phen	0.90410831
70	MP0001963_abnormal_hearing_physiology	0.90155648
71	MP0005174_abnormal_tail_pigmentation	0.89969924
72	MP0009046_muscle_twitch	0.89416956
73	MP0001873_stomach_inflammation	0.88820656
74	MP0002106_abnormal_muscle_physiology	0.88613933
75	MP0002089_abnormal_postnatal_growth/wei	0.88474999
76	MP0002148_abnormal_hypersensitivity_rea	0.87826386
77	MP0005085_abnormal_gallbladder_physiolo	0.86638740
78	MP0006035_abnormal_mitochondrial_morpho	0.86562397
79	MP0000749_muscle_degeneration	0.86305575
80	MP0005636_abnormal_mineral_homeostasis	0.85913362
81	MP0002166_altered_tumor_susceptibility	0.85561287
82	MP0002006_tumorigenesis	0.85559747
83	MP0000230_abnormal_systemic_arterial	0.83781433
84	MP0005000_abnormal_immune_tolerance	0.79689337
85	MP0000631_abnormal_neuroendocrine_gland	0.79403003
86	MP0004742_abnormal_vestibular_system	0.79353246
87	MP0003638_abnormal_response/metabolism_	0.79315688
88	MP0002733_abnormal_thermal_nociception	0.78765126
89	MP0005423_abnormal_somatic_nervous	0.77940166
90	MP0002452_abnormal_antigen_presenting	0.76087148
91	MP0009785_altered_susceptibility_to	0.74015730
92	MP0002184_abnormal_innervation	0.73989254
93	MP0008058_abnormal_DNA_repair	0.73961721
94	MP0001293_anophthalmia	0.73325422
95	MP0002557_abnormal_social/conspecific_i	0.73316592
96	MP0004215_abnormal_myocardial_fiber	0.72967297
97	MP0002638_abnormal_pupillary_reflex	0.72264167
98	MP0000026_abnormal_inner_ear	0.71672824
99	MP0002752_abnormal_somatic_nervous	0.68985803
100	MP0001756_abnormal_urination	0.66912420

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.24317023
2	Abnormality of midbrain morphology (HP:0002418)	4.04661650
3	Molar tooth sign on MRI (HP:0002419)	4.04661650
4	Acute necrotizing encephalopathy (HP:0006965)	3.96574638
5	Mitochondrial inheritance (HP:0001427)	3.50721967
6	Acute encephalopathy (HP:0006846)	3.47918873
7	Pancreatic cysts (HP:0001737)	3.44859694
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.44799577
9	Medial flaring of the eyebrow (HP:0010747)	3.39077495
10	Progressive macrocephaly (HP:0004481)	3.37186930
11	Hepatocellular necrosis (HP:0001404)	3.33229826
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.18217862
13	Increased CSF lactate (HP:0002490)	3.11540865
14	Pancreatic fibrosis (HP:0100732)	3.07096579
15	Stenosis of the external auditory canal (HP:0000402)	3.00203178
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.98937986
17	Hepatic necrosis (HP:0002605)	2.90637800
18	Polydipsia (HP:0001959)	2.88485540
19	Abnormal drinking behavior (HP:0030082)	2.88485540
20	Renal Fanconi syndrome (HP:0001994)	2.88211807
21	Congenital stationary night blindness (HP:0007642)	2.71916604
22	True hermaphroditism (HP:0010459)	2.71464339
23	3-Methylglutaconic aciduria (HP:0003535)	2.71033377
24	Elevated erythrocyte sedimentation rate (HP:0003565)	2.70297882
25	Nephronophthisis (HP:0000090)	2.69837068
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.65494560
27	Nephrogenic diabetes insipidus (HP:0009806)	2.64682929
28	Macrocytic anemia (HP:0001972)	2.63570669
29	Methylmalonic acidemia (HP:0002912)	2.60376759
30	Congenital primary aphakia (HP:0007707)	2.58887587
31	Gait imbalance (HP:0002141)	2.57030794
32	Abnormal hemoglobin (HP:0011902)	2.55493156
33	Abolished electroretinogram (ERG) (HP:0000550)	2.51492661
34	Pallor (HP:0000980)	2.51133235
35	Abnormality of the prostate (HP:0008775)	2.43666094
36	Congenital, generalized hypertrichosis (HP:0004540)	2.37046488
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.34594197
38	Abnormality of alanine metabolism (HP:0010916)	2.34594197
39	Hyperalaninemia (HP:0003348)	2.34594197
40	Type II lissencephaly (HP:0007260)	2.31626466
41	Rectovaginal fistula (HP:0000143)	2.30913386
42	Rectal fistula (HP:0100590)	2.30913386
43	Optic disc pallor (HP:0000543)	2.28317813
44	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28208282
45	Type 2 muscle fiber atrophy (HP:0003554)	2.23899783
46	Cerebral edema (HP:0002181)	2.23346766
47	Absent phalangeal crease (HP:0006109)	2.21703567
48	Polyuria (HP:0000103)	2.21230265
49	IgG deficiency (HP:0004315)	2.19236632
50	Abnormality of the renal medulla (HP:0100957)	2.19094792
51	Abnormal number of erythroid precursors (HP:0012131)	2.18615767
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18249561
53	Palpebral edema (HP:0100540)	2.18095175
54	Asplenia (HP:0001746)	2.17638331
55	Increased serum lactate (HP:0002151)	2.16682874
56	Sclerocornea (HP:0000647)	2.16345725
57	Abnormality of the costochondral junction (HP:0000919)	2.16179193
58	Failure to thrive in infancy (HP:0001531)	2.15813363
59	Absent thumb (HP:0009777)	2.10441622
60	Anencephaly (HP:0002323)	2.09517255
61	Hypoproteinemia (HP:0003075)	2.04920495
62	Lipid accumulation in hepatocytes (HP:0006561)	2.01643343
63	Lactic acidosis (HP:0003128)	2.01552997
64	Postaxial foot polydactyly (HP:0001830)	2.00826954
65	Methylmalonic aciduria (HP:0012120)	2.00192359
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.99002005
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.99002005
68	Abnormality of renal resorption (HP:0011038)	1.98568895
69	Round ear (HP:0100830)	1.97702922
70	Increased hepatocellular lipid droplets (HP:0006565)	1.97290399
71	Keratoconus (HP:0000563)	1.96022874
72	Increased corneal curvature (HP:0100692)	1.96022874
73	Porencephaly (HP:0002132)	1.95262386
74	Generalized aminoaciduria (HP:0002909)	1.94683103
75	Distal arthrogryposis (HP:0005684)	1.94005337
76	Congenital hepatic fibrosis (HP:0002612)	1.93397035
77	Hyperglycinemia (HP:0002154)	1.92803789
78	Poor coordination (HP:0002370)	1.91666746
79	Attenuation of retinal blood vessels (HP:0007843)	1.91416515
80	Constricted visual fields (HP:0001133)	1.90151845
81	Focal motor seizures (HP:0011153)	1.86651050
82	Lissencephaly (HP:0001339)	1.86197256
83	Microretrognathia (HP:0000308)	1.85746733
84	Colon cancer (HP:0003003)	1.84945151
85	Reduced antithrombin III activity (HP:0001976)	1.83678012
86	Pendular nystagmus (HP:0012043)	1.82575651
87	Respiratory failure (HP:0002878)	1.82370611
88	Periorbital edema (HP:0100539)	1.81602123
89	Partial duplication of thumb phalanx (HP:0009944)	1.80994281
90	Leukodystrophy (HP:0002415)	1.80543742
91	Abnormal biliary tract physiology (HP:0012439)	1.78583622
92	Bile duct proliferation (HP:0001408)	1.78583622
93	Tetany (HP:0001281)	1.77871816
94	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76612352
95	Abnormality of the renal cortex (HP:0011035)	1.76491581
96	Vaginal atresia (HP:0000148)	1.75776067
97	Muscle fiber atrophy (HP:0100295)	1.75150170
98	Facial edema (HP:0000282)	1.74956474
99	Lethargy (HP:0001254)	1.74502588
100	Abnormal urine output (HP:0012590)	1.74496977

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.39428123
2	CDK19	2.96643408
3	TXK	2.90838075
4	TLK1	2.90626630
5	FRK	2.46694924
6	NUAK1	2.29217120
7	ZAK	2.28577238
8	STK16	2.25227437
9	TIE1	2.16815735
10	TAOK3	2.16543181
11	OXSR1	2.12208221
12	ADRBK2	2.09557352
13	GRK1	1.93713767
14	MAP3K12	1.91023561
15	PHKG2	1.84636818
16	PHKG1	1.84636818
17	WNK4	1.72909040
18	PINK1	1.65529172
19	MAPK13	1.63172935
20	VRK2	1.61078893
21	BMPR2	1.56643207
22	EIF2AK3	1.54125641
23	KIT	1.50614740
24	FLT3	1.42935515
25	TEC	1.41088642
26	OBSCN	1.36303179
27	BCKDK	1.32605364
28	TRIM28	1.29298675
29	IKBKE	1.24204790
30	TYRO3	1.23573056
31	CSF1R	1.12088709
32	GRK6	1.08487476
33	STK39	1.07677689
34	ITK	1.06499891
35	MYLK	1.05903121
36	DYRK2	1.05376999
37	CCNB1	1.03973774
38	GRK7	1.03725142
39	IKBKB	1.00317374
40	PIK3CA	0.98653628
41	EIF2AK1	0.98514045
42	MST4	0.91836269
43	DAPK3	0.88969648
44	PLK4	0.88746689
45	EIF2AK2	0.86387515
46	ADRBK1	0.84861218
47	CAMKK2	0.78703561
48	EPHA4	0.78085649
49	INSRR	0.77770680
50	ERBB3	0.75042585
51	DAPK1	0.74652496
52	NEK1	0.73766244
53	SYK	0.73074262
54	NEK2	0.71798521
55	CSNK1G2	0.71716353
56	MKNK2	0.68840525
57	VRK1	0.68539487
58	PIK3CG	0.65842031
59	PKN1	0.65272160
60	GRK5	0.64992807
61	RPS6KA5	0.64092487
62	CSNK1G3	0.62897663
63	ILK	0.62011957
64	LIMK1	0.59470376
65	MAP2K2	0.58985886
66	CAMK1	0.58248009
67	PRKCE	0.58187960
68	IGF1R	0.56648779
69	PLK2	0.56379387
70	PIM1	0.56260666
71	BLK	0.53801573
72	LRRK2	0.53130623
73	PDK2	0.53069077
74	PRKACA	0.53051282
75	FES	0.51735983
76	CHEK2	0.51549584
77	MAP2K6	0.51535533
78	BTK	0.51381609
79	DYRK1B	0.50639871
80	BMPR1B	0.50315712
81	NME1	0.50221658
82	NTRK3	0.50172667
83	PRKCG	0.49581994
84	NME2	0.48648144
85	DAPK2	0.47839291
86	WNK1	0.46856740
87	STK38L	0.46841796
88	LCK	0.45858415
89	MAP3K14	0.45408787
90	WNK3	0.45174887
91	LYN	0.45174424
92	KDR	0.43295319
93	SRPK1	0.42342621
94	SCYL2	0.41582772
95	TRPM7	0.41542455
96	CSNK2A2	0.41178725
97	CAMK4	0.41101172
98	AURKB	0.40777261
99	CSNK1A1L	0.40629363
100	STK3	0.39632879

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.35370859
2	Ribosome_Homo sapiens_hsa03010	4.32404167
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49397048
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.93548571
5	Allograft rejection_Homo sapiens_hsa05330	2.91387856
6	Parkinsons disease_Homo sapiens_hsa05012	2.83036110
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.81489276
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.77907563
9	Proteasome_Homo sapiens_hsa03050	2.76628612
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.39381513
11	RNA polymerase_Homo sapiens_hsa03020	2.07463526
12	Alzheimers disease_Homo sapiens_hsa05010	2.05468356
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.01672460
14	Protein export_Homo sapiens_hsa03060	1.96399036
15	Huntingtons disease_Homo sapiens_hsa05016	1.82502390
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.72756355
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.69887048
18	RNA degradation_Homo sapiens_hsa03018	1.65731549
19	Regulation of autophagy_Homo sapiens_hsa04140	1.59345905
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58442953
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57739879
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56346187
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50534876
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49244372
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37120345
26	Phototransduction_Homo sapiens_hsa04744	1.36903633
27	One carbon pool by folate_Homo sapiens_hsa00670	1.36022825
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31526750
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31084723
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.30417602
31	Homologous recombination_Homo sapiens_hsa03440	1.15732591
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12078176
33	Olfactory transduction_Homo sapiens_hsa04740	1.03174036
34	Viral myocarditis_Homo sapiens_hsa05416	1.02567005
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98077361
36	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96710850
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96513976
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.94616369
39	Butanoate metabolism_Homo sapiens_hsa00650	0.92535609
40	Salivary secretion_Homo sapiens_hsa04970	0.92353243
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91205090
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.90233775
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90064177
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89494804
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86177071
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85662096
47	Spliceosome_Homo sapiens_hsa03040	0.83554962
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81288290
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81124289
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77669743
51	Sulfur metabolism_Homo sapiens_hsa00920	0.75988636
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.73969609
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73293475
54	Leishmaniasis_Homo sapiens_hsa05140	0.73200864
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71645504
56	Basal transcription factors_Homo sapiens_hsa03022	0.71433848
57	Purine metabolism_Homo sapiens_hsa00230	0.71053894
58	Propanoate metabolism_Homo sapiens_hsa00640	0.66995454
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66530473
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65335250
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63743457
62	RNA transport_Homo sapiens_hsa03013	0.61054606
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57826713
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.56950294
65	Nicotine addiction_Homo sapiens_hsa05033	0.55141018
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55035656
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.54470750
68	Circadian entrainment_Homo sapiens_hsa04713	0.54100355
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53324896
70	Peroxisome_Homo sapiens_hsa04146	0.52109433
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50803956
72	Metabolic pathways_Homo sapiens_hsa01100	0.49796212
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49098753
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48409447
75	Renin secretion_Homo sapiens_hsa04924	0.48184464
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48055546
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47413164
78	Caffeine metabolism_Homo sapiens_hsa00232	0.44316800
79	Morphine addiction_Homo sapiens_hsa05032	0.44293270
80	Mismatch repair_Homo sapiens_hsa03430	0.43971890
81	Taste transduction_Homo sapiens_hsa04742	0.43673483
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42519055
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42171727
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41938787
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40396732
86	Fatty acid degradation_Homo sapiens_hsa00071	0.38567884
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37737652
88	Retinol metabolism_Homo sapiens_hsa00830	0.35481852
89	Herpes simplex infection_Homo sapiens_hsa05168	0.34364466
90	Serotonergic synapse_Homo sapiens_hsa04726	0.29904816
91	DNA replication_Homo sapiens_hsa03030	0.29775280
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28165890
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.25267381
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25129084
95	Fatty acid elongation_Homo sapiens_hsa00062	0.24269569
96	Glutathione metabolism_Homo sapiens_hsa00480	0.21532601
97	Insulin secretion_Homo sapiens_hsa04911	0.18060740
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.17935265
99	GABAergic synapse_Homo sapiens_hsa04727	0.17100922
100	Tuberculosis_Homo sapiens_hsa05152	0.17061353

RPS3AP22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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