ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	7.21034184
2	positive regulation of interleukin-17 production (GO:0032740)	6.75652811
3	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	6.29518689
4	L-alpha-amino acid transmembrane transport (GO:1902475)	6.00167235
5	rRNA catabolic process (GO:0016075)	5.90784601
6	regulation of isotype switching to IgG isotypes (GO:0048302)	5.54611060
7	regulation of activation of Janus kinase activity (GO:0010533)	5.42287164
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.28677268
9	rRNA methylation (GO:0031167)	5.15488918
10	regulation of G0 to G1 transition (GO:0070316)	5.11047961
11	rRNA modification (GO:0000154)	5.05001951
12	positive regulation of natural killer cell differentiation (GO:0032825)	4.81348681
13	regulation of MHC class I biosynthetic process (GO:0045343)	4.81067908
14	negative regulation of B cell apoptotic process (GO:0002903)	4.76509434
15	regulation of regulatory T cell differentiation (GO:0045589)	4.54493054
16	negative regulation of type 2 immune response (GO:0002829)	4.43017682
17	positive regulation of cell fate commitment (GO:0010455)	4.38814086
18	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	4.26239427
19	cytidine metabolic process (GO:0046087)	4.20958857
20	cytidine catabolic process (GO:0006216)	4.20958857
21	cytidine deamination (GO:0009972)	4.20958857
22	cellular response to reactive nitrogen species (GO:1902170)	4.12302032
23	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.07486376
24	organelle disassembly (GO:1903008)	4.07455118
25	positive regulation of defense response to virus by host (GO:0002230)	4.03824734
26	ribosomal small subunit assembly (GO:0000028)	4.00933524
27	positive regulation of isotype switching (GO:0045830)	3.90665247
28	regulation of interleukin-13 production (GO:0032656)	3.90615144
29	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.84490784
30	GPI anchor biosynthetic process (GO:0006506)	3.82498097
31	positive regulation of DNA recombination (GO:0045911)	3.79649891
32	GPI anchor metabolic process (GO:0006505)	3.71709387
33	viral transcription (GO:0019083)	3.66445552
34	negative regulation of fatty acid metabolic process (GO:0045922)	3.62840575
35	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.59477962
36	DNA deamination (GO:0045006)	3.58845286
37	proteasome assembly (GO:0043248)	3.58575516
38	translational termination (GO:0006415)	3.56790963
39	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	3.54921096
40	protein targeting to ER (GO:0045047)	3.53903898
41	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.53537421
42	positive regulation of JAK-STAT cascade (GO:0046427)	3.50715733
43	mucosal-associated lymphoid tissue development (GO:0048537)	3.47781350
44	Peyers patch development (GO:0048541)	3.47781350
45	protein localization to endoplasmic reticulum (GO:0070972)	3.44938648
46	metallo-sulfur cluster assembly (GO:0031163)	3.41867088
47	iron-sulfur cluster assembly (GO:0016226)	3.41867088
48	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.41162721
49	ribonucleoprotein complex disassembly (GO:0032988)	3.41148670
50	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.38425921
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35791939
52	cotranslational protein targeting to membrane (GO:0006613)	3.31434601
53	regulation of interleukin-17 production (GO:0032660)	3.27695831
54	regulation of immunoglobulin secretion (GO:0051023)	3.26877012
55	regulation of B cell apoptotic process (GO:0002902)	3.25433580
56	negative regulation by host of viral transcription (GO:0043922)	3.24816446
57	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.22271085
58	ncRNA catabolic process (GO:0034661)	3.21626856
59	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.21542531
60	regulation of chromatin binding (GO:0035561)	3.20981786
61	positive regulation of activated T cell proliferation (GO:0042104)	3.20670601
62	regulation of natural killer cell differentiation (GO:0032823)	3.19953973
63	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.19773822
64	positive regulation of natural killer cell activation (GO:0032816)	3.19469367
65	negative regulation of monooxygenase activity (GO:0032769)	3.18519920
66	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.17744677
67	ATP synthesis coupled proton transport (GO:0015986)	3.17744677
68	maturation of SSU-rRNA (GO:0030490)	3.17544355
69	phenylpropanoid metabolic process (GO:0009698)	3.16978832
70	translational elongation (GO:0006414)	3.14468241
71	cellular response to nitric oxide (GO:0071732)	3.10938093
72	positive regulation of interferon-gamma production (GO:0032729)	3.08961997
73	platelet dense granule organization (GO:0060155)	3.08872907
74	positive regulation of T-helper 1 type immune response (GO:0002827)	2.98881125
75	regulation of T cell tolerance induction (GO:0002664)	2.96390651
76	protein neddylation (GO:0045116)	2.94762924
77	negative regulation of granulocyte differentiation (GO:0030853)	2.93272900
78	purine deoxyribonucleotide catabolic process (GO:0009155)	2.91623547
79	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.90253229
80	regulation of alpha-beta T cell proliferation (GO:0046640)	2.89809562
81	inner mitochondrial membrane organization (GO:0007007)	2.88181175
82	viral life cycle (GO:0019058)	2.87967090
83	peptidyl-arginine omega-N-methylation (GO:0035247)	2.87033858
84	negative regulation of T cell differentiation (GO:0045581)	2.84309899
85	regulation of interleukin-5 production (GO:0032674)	2.82434366
86	positive regulation of tolerance induction (GO:0002645)	2.79866211
87	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.79419049
88	centrosome localization (GO:0051642)	2.76869942
89	negative regulation of macroautophagy (GO:0016242)	2.75310000
90	electron transport chain (GO:0022900)	2.74375870
91	negative regulation of glucose transport (GO:0010829)	2.71979272
92	mannosylation (GO:0097502)	2.71006389
93	respiratory electron transport chain (GO:0022904)	2.70803414
94	regulation of T cell mediated cytotoxicity (GO:0001914)	2.70054064
95	auditory receptor cell stereocilium organization (GO:0060088)	2.69486649
96	chaperone-mediated protein transport (GO:0072321)	2.69038135
97	flavonoid metabolic process (GO:0009812)	2.67927908
98	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.67798374
99	neurotransmitter catabolic process (GO:0042135)	2.67357399
100	regulation of memory T cell differentiation (GO:0043380)	11.1106199

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.51777347
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.29374577
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.74555221
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.67204702
5	ELK1_19687146_ChIP-ChIP_HELA_Human	3.28351957
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.13651392
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12475291
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.09780289
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92642623
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.86743723
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.64626756
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.53476416
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.52446546
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.51281329
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.40033802
16	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.39807101
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.14100217
18	VDR_22108803_ChIP-Seq_LS180_Human	2.12076748
19	FUS_26573619_Chip-Seq_HEK293_Human	2.02468186
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.92311662
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.91579168
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87022714
23	TP53_16413492_ChIP-PET_HCT116_Human	1.85773808
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.80363375
25	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.79763892
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.79255920
27	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.79133097
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.69963658
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.65093195
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63276750
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62794285
32	GATA3_26560356_Chip-Seq_TH2_Human	1.60483377
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59366304
34	RUNX_20019798_ChIP-Seq_JUKART_Human	1.57990045
35	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.52431073
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52208691
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50365690
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.50365690
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48162916
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46317966
41	EWS_26573619_Chip-Seq_HEK293_Human	1.41544782
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.41320484
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40801716
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39305491
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34015425
46	NCOR_22424771_ChIP-Seq_293T_Human	1.33284554
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30354619
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.29048762
49	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25905579
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.25722437
51	GATA3_27048872_Chip-Seq_THYMUS_Human	1.25133419
52	AR_20517297_ChIP-Seq_VCAP_Human	1.23615548
53	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.22373903
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21819553
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20446195
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19940707
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19069597
58	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.17695254
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17616809
60	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.17589399
61	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.17358995
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17062759
63	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15950478
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14805175
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14700539
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13368886
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12178957
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11783491
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10581944
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10581944
71	CIITA_25753668_ChIP-Seq_RAJI_Human	1.08959551
72	MYB_26560356_Chip-Seq_TH2_Human	1.08937175
73	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.08769682
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08585868
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08585868
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07112904
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.05903736
78	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.05722224
79	TTF2_22483619_ChIP-Seq_HELA_Human	1.05619763
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05466145
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04043636
82	XRN2_22483619_ChIP-Seq_HELA_Human	1.03590960
83	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.02233517
84	CEBPB_22108803_ChIP-Seq_LS180_Human	0.99520697
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97458244
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97272268
87	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97183586
88	JUN_21703547_ChIP-Seq_K562_Human	0.96527547
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.96205865
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.94506989
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.94024334
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92514946
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.92314744
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91836145
95	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91105279
96	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.90926641
97	GATA3_26560356_Chip-Seq_TH1_Human	0.88576940
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.86999433
99	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.86763630
100	P300_19829295_ChIP-Seq_ESCs_Human	0.86610593

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	9.06954014
2	MP0000372_irregular_coat_pigmentation	3.94662805
3	MP0005174_abnormal_tail_pigmentation	3.61086678
4	MP0009379_abnormal_foot_pigmentation	3.18756948
5	MP0002938_white_spotting	2.58199931
6	MP0008058_abnormal_DNA_repair	2.44943193
7	MP0008004_abnormal_stomach_pH	2.41659742
8	MP0002132_abnormal_respiratory_system	2.36770116
9	MP0000537_abnormal_urethra_morphology	2.30873195
10	MP0002160_abnormal_reproductive_system	2.30631385
11	MP0000015_abnormal_ear_pigmentation	2.17885023
12	MP0002102_abnormal_ear_morphology	2.16807270
13	MP0003123_paternal_imprinting	2.00538986
14	MP0005645_abnormal_hypothalamus_physiol	1.91974598
15	MP0004147_increased_porphyrin_level	1.90618719
16	MP0001835_abnormal_antigen_presentation	1.87497921
17	MP0006292_abnormal_olfactory_placode	1.84570022
18	MP0009697_abnormal_copulation	1.82378444
19	MP0003011_delayed_dark_adaptation	1.77473367
20	MP0005646_abnormal_pituitary_gland	1.75181274
21	MP0009785_altered_susceptibility_to	1.70478353
22	MP0003950_abnormal_plasma_membrane	1.69081077
23	MP0002148_abnormal_hypersensitivity_rea	1.63733989
24	MP0005389_reproductive_system_phenotype	1.63250495
25	MP0002095_abnormal_skin_pigmentation	1.61639649
26	MP0002736_abnormal_nociception_after	1.58934894
27	MP0003763_abnormal_thymus_physiology	1.55593479
28	MP0001853_heart_inflammation	1.51622046
29	MP0006036_abnormal_mitochondrial_physio	1.51412398
30	MP0002138_abnormal_hepatobiliary_system	1.51259134
31	MP0002837_dystrophic_cardiac_calcinosis	1.50375307
32	MP0010155_abnormal_intestine_physiology	1.48710591
33	MP0003693_abnormal_embryo_hatching	1.42707058
34	MP0002234_abnormal_pharynx_morphology	1.42080775
35	MP0003300_gastrointestinal_ulcer	1.41424837
36	MP0005671_abnormal_response_to	1.36677908
37	MP0003806_abnormal_nucleotide_metabolis	1.35840108
38	MP0003646_muscle_fatigue	1.33796087
39	MP0010030_abnormal_orbit_morphology	1.31107410
40	MP0006082_CNS_inflammation	1.30727806
41	MP0005670_abnormal_white_adipose	1.28189720
42	MP0001986_abnormal_taste_sensitivity	1.25044152
43	MP0005075_abnormal_melanosome_morpholog	1.24903943
44	MP0001968_abnormal_touch/_nociception	1.15001713
45	MP0004742_abnormal_vestibular_system	1.14376741
46	MP0003880_abnormal_central_pattern	1.14274745
47	MP0005000_abnormal_immune_tolerance	1.13880706
48	MP0005503_abnormal_tendon_morphology	1.13871070
49	MP0009764_decreased_sensitivity_to	1.11186731
50	MP0008875_abnormal_xenobiotic_pharmacok	1.04882590
51	MP0000465_gastrointestinal_hemorrhage	1.03136118
52	MP0001800_abnormal_humoral_immune	1.02811342
53	MP0008872_abnormal_physiological_respon	1.01512771
54	MP0005025_abnormal_response_to	0.98862233
55	MP0003786_premature_aging	0.94771657
56	MP0002405_respiratory_system_inflammati	0.90392181
57	MP0001845_abnormal_inflammatory_respons	0.89836364
58	MP0003938_abnormal_ear_development	0.85459973
59	MP0000703_abnormal_thymus_morphology	0.84453682
60	MP0005171_absent_coat_pigmentation	0.84444241
61	MP0005387_immune_system_phenotype	0.83404795
62	MP0001790_abnormal_immune_system	0.83404795
63	MP0003866_abnormal_defecation	0.83141945
64	MP0003122_maternal_imprinting	0.82786880
65	MP0001919_abnormal_reproductive_system	0.81185334
66	MP0009333_abnormal_splenocyte_physiolog	0.80099971
67	MP0005551_abnormal_eye_electrophysiolog	0.77962103
68	MP0002723_abnormal_immune_serum	0.77627965
69	MP0004133_heterotaxia	0.76627243
70	MP0002398_abnormal_bone_marrow	0.75371986
71	MP0005410_abnormal_fertilization	0.74122216
72	MP0006276_abnormal_autonomic_nervous	0.72484026
73	MP0004885_abnormal_endolymph	0.71536586
74	MP0003567_abnormal_fetal_cardiomyocyte	0.71416042
75	MP0004883_abnormal_blood_vessel	0.69973937
76	MP0001905_abnormal_dopamine_level	0.69705014
77	MP0004808_abnormal_hematopoietic_stem	0.68591378
78	MP0001485_abnormal_pinna_reflex	0.68199145
79	MP0005084_abnormal_gallbladder_morpholo	0.66335746
80	MP0002420_abnormal_adaptive_immunity	0.65944173
81	MP0003186_abnormal_redox_activity	0.65797730
82	MP0005408_hypopigmentation	0.65038116
83	MP0001819_abnormal_immune_cell	0.63382700
84	MP0004145_abnormal_muscle_electrophysio	0.62248552
85	MP0002163_abnormal_gland_morphology	0.61991394
86	MP0003172_abnormal_lysosome_physiology	0.61442976
87	MP0002722_abnormal_immune_system	0.61404398
88	MP0003878_abnormal_ear_physiology	0.60969819
89	MP0005377_hearing/vestibular/ear_phenot	0.60969819
90	MP0002693_abnormal_pancreas_physiology	0.60947321
91	MP0005166_decreased_susceptibility_to	0.60676350
92	MP0004130_abnormal_muscle_cell	0.59813064
93	MP0004484_altered_response_of	0.59508916
94	MP0001881_abnormal_mammary_gland	0.55878433
95	MP0005448_abnormal_energy_balance	0.54197851
96	MP0002933_joint_inflammation	0.53566128
97	MP0000716_abnormal_immune_system	0.52872065
98	MP0002822_catalepsy	0.51678281
99	MP0000689_abnormal_spleen_morphology	0.51560307
100	MP0008789_abnormal_olfactory_epithelium	0.51524041

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased intramyocellular lipid droplets (HP:0012240)	5.25037828
2	Increased hepatocellular lipid droplets (HP:0006565)	4.40721567
3	Increased muscle lipid content (HP:0009058)	4.36815186
4	B lymphocytopenia (HP:0010976)	4.31081223
5	Abnormality of B cell number (HP:0010975)	4.16097725
6	Lipid accumulation in hepatocytes (HP:0006561)	3.93056070
7	Albinism (HP:0001022)	3.89386420
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.61297015
9	Hypoplasia of the pons (HP:0012110)	3.55670847
10	Mitochondrial inheritance (HP:0001427)	3.54311809
11	T lymphocytopenia (HP:0005403)	3.51025402
12	Acute necrotizing encephalopathy (HP:0006965)	3.42216978
13	Abnormality of the pons (HP:0007361)	3.42059328
14	Respiratory difficulties (HP:0002880)	3.39387956
15	Exertional dyspnea (HP:0002875)	3.34144897
16	Severe visual impairment (HP:0001141)	3.24723713
17	Abnormality of T cell number (HP:0011839)	3.17872934
18	Renal Fanconi syndrome (HP:0001994)	3.12869557
19	Increased CSF lactate (HP:0002490)	3.12560987
20	Acute encephalopathy (HP:0006846)	3.07679845
21	Hematochezia (HP:0002573)	2.98525191
22	Renal cortical cysts (HP:0000803)	2.97337930
23	Type 2 muscle fiber atrophy (HP:0003554)	2.96941336
24	Progressive macrocephaly (HP:0004481)	2.85590436
25	Lower limb hyperreflexia (HP:0002395)	2.79115896
26	Conical tooth (HP:0000698)	2.77044566
27	Reticulocytopenia (HP:0001896)	2.71308938
28	Type I transferrin isoform profile (HP:0003642)	2.68805130
29	Palpebral edema (HP:0100540)	2.65250109
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.61098143
31	Inflammation of the large intestine (HP:0002037)	2.59454233
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.57733096
33	Abnormality of alanine metabolism (HP:0010916)	2.57733096
34	Hyperalaninemia (HP:0003348)	2.57733096
35	Hepatocellular necrosis (HP:0001404)	2.57232302
36	Thyroiditis (HP:0100646)	2.54207461
37	Hyperglycinemia (HP:0002154)	2.53127707
38	Eosinophilia (HP:0001880)	2.51738712
39	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.50144919
40	Spontaneous hematomas (HP:0007420)	2.49974882
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.48611069
42	True hermaphroditism (HP:0010459)	2.45137030
43	Concave nail (HP:0001598)	2.43235416
44	Severe combined immunodeficiency (HP:0004430)	2.42016443
45	Ventricular fibrillation (HP:0001663)	2.39221576
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.38572340
47	Nasal polyposis (HP:0100582)	2.38565665
48	Hypothermia (HP:0002045)	2.36042816
49	IgG deficiency (HP:0004315)	2.35949828
50	Muscle fiber atrophy (HP:0100295)	2.33174386
51	Hepatic necrosis (HP:0002605)	2.30909462
52	Type II lissencephaly (HP:0007260)	2.26091139
53	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.26032136
54	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.26032136
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.25642788
56	Gastrointestinal inflammation (HP:0004386)	2.24708538
57	3-Methylglutaconic aciduria (HP:0003535)	2.21711113
58	Absent thumb (HP:0009777)	2.19816980
59	Exercise intolerance (HP:0003546)	2.19641849
60	Anhidrosis (HP:0000970)	2.19224610
61	Absent speech (HP:0001344)	2.15543426
62	Congenital stationary night blindness (HP:0007642)	2.14803795
63	Abnormality of eosinophils (HP:0001879)	2.14404179
64	Abnormality of the parietal bone (HP:0002696)	2.13752338
65	Generalized hypopigmentation (HP:0007513)	2.12757485
66	Bile duct proliferation (HP:0001408)	2.12339500
67	Abnormal biliary tract physiology (HP:0012439)	2.12339500
68	Sensorimotor neuropathy (HP:0007141)	2.12028306
69	Prolonged QT interval (HP:0001657)	2.06827071
70	Degeneration of anterior horn cells (HP:0002398)	2.05497862
71	Abnormality of the anterior horn cell (HP:0006802)	2.05497862
72	Methylmalonic aciduria (HP:0012120)	2.05410339
73	Pancreatic cysts (HP:0001737)	2.04828285
74	Abnormality of renal resorption (HP:0011038)	2.04200811
75	Pancreatic fibrosis (HP:0100732)	2.02688324
76	Hyperphosphaturia (HP:0003109)	2.02325099
77	Abnormality of T cells (HP:0002843)	2.01291633
78	Glycosuria (HP:0003076)	2.00506046
79	Abnormality of urine glucose concentration (HP:0011016)	2.00506046
80	Weak cry (HP:0001612)	1.98473233
81	Spastic paraparesis (HP:0002313)	1.98155253
82	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.97501060
83	Abnormality of the nasal mucosa (HP:0000433)	1.92977604
84	Increased IgM level (HP:0003496)	1.92582369
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91447895
86	Congenital, generalized hypertrichosis (HP:0004540)	1.91346102
87	Macrocytic anemia (HP:0001972)	1.90708141
88	Abnormality of cells of the erythroid lineage (HP:0012130)	1.89507452
89	Dyschromatopsia (HP:0007641)	1.89259162
90	Supernumerary bones of the axial skeleton (HP:0009144)	1.88362301
91	Supernumerary spleens (HP:0009799)	1.88213254
92	Generalized aminoaciduria (HP:0002909)	1.87280408
93	Optic disc pallor (HP:0000543)	1.85656495
94	Abnormal number of erythroid precursors (HP:0012131)	1.84737060
95	Reduced antithrombin III activity (HP:0001976)	1.80575072
96	Neutropenia (HP:0001875)	1.80232598
97	Metaphyseal dysplasia (HP:0100255)	1.80169059
98	Autoamputation (HP:0001218)	1.78188069
99	Hypoplasia of the radius (HP:0002984)	1.77469481
100	Lactic acidosis (HP:0003128)	1.76705882

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.64517724
2	ADRBK2	3.85257058
3	TIE1	3.84902455
4	TLK1	3.69939353
5	VRK1	2.94524158
6	RPS6KA4	2.70566786
7	VRK2	2.58299191
8	MAP3K5	2.43966270
9	GRK7	2.26792291
10	BMPR2	2.18032146
11	RIPK4	2.06978725
12	GRK1	2.06396245
13	NUAK1	1.98122001
14	TESK2	1.92178214
15	BRSK2	1.87976551
16	EIF2AK1	1.81548950
17	ITK	1.81546833
18	RPS6KA5	1.76615106
19	NLK	1.72364659
20	TYK2	1.71938029
21	KDR	1.70462968
22	TEC	1.57483514
23	BMPR1B	1.50361419
24	CSK	1.43969910
25	CAMKK2	1.43749748
26	FRK	1.38002610
27	NEK6	1.36237099
28	MST4	1.35507196
29	MAP4K2	1.30291491
30	PRKCQ	1.27627830
31	JAK1	1.24030647
32	PIM1	1.22064991
33	MAP3K9	1.16968003
34	FES	1.11627897
35	PDK2	1.05666323
36	IKBKE	1.03395464
37	PBK	0.94950609
38	TXK	0.91427281
39	CDC7	0.90911681
40	KIT	0.90694773
41	ALK	0.90228461
42	CDK3	0.89572437
43	BCKDK	0.86223729
44	NEK1	0.83051153
45	BTK	0.81319330
46	WNK4	0.78928908
47	CAMK1	0.78703804
48	CDK4	0.78064212
49	MELK	0.77893305
50	IKBKB	0.75329221
51	CHUK	0.74907326
52	CSNK1G1	0.74759138
53	STK39	0.70009782
54	DYRK1A	0.69188475
55	WNK1	0.67960774
56	TGFBR1	0.65051167
57	INSRR	0.64740278
58	EPHA4	0.60008602
59	PHKG2	0.58680013
60	PHKG1	0.58680013
61	IRAK4	0.57804271
62	JAK3	0.57363903
63	IRAK1	0.56930508
64	ADRBK1	0.56253426
65	PLK4	0.52439418
66	MAPK13	0.50387277
67	LCK	0.49360166
68	PLK3	0.49090036
69	PLK2	0.48971206
70	PIK3CA	0.48843875
71	CSNK1A1	0.48664344
72	PAK4	0.45804625
73	AKT2	0.45082889
74	LRRK2	0.44594589
75	MATK	0.44293474
76	MYLK	0.44033824
77	PIK3CG	0.41983621
78	DYRK2	0.40266604
79	PAK3	0.39896229
80	OXSR1	0.39709329
81	GRK5	0.39397204
82	MAP3K4	0.39005157
83	STK16	0.38091037
84	JAK2	0.36877807
85	TAOK3	0.36805874
86	CAMK2B	0.36794757
87	ERBB2	0.36486544
88	AURKB	0.36183826
89	PRKCI	0.36168590
90	EPHA2	0.35699752
91	GRK6	0.35585651
92	PAK1	0.34683871
93	CAMK2G	0.34627945
94	ROCK1	0.34199063
95	MAP2K7	0.31969390
96	PRKCE	0.31947474
97	MAP3K12	0.30330447
98	SGK1	0.29723103
99	STK24	0.29500392
100	CSNK2A1	0.28297766

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.28550371
2	Proteasome_Homo sapiens_hsa03050	4.15890381
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.56500737
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.51262656
5	Sulfur metabolism_Homo sapiens_hsa00920	3.26605297
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.06396756
7	Parkinsons disease_Homo sapiens_hsa05012	2.81093887
8	Basal transcription factors_Homo sapiens_hsa03022	2.28384425
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16913838
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.13470333
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09068911
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.98581258
13	Homologous recombination_Homo sapiens_hsa03440	1.92413650
14	Allograft rejection_Homo sapiens_hsa05330	1.90046653
15	Alzheimers disease_Homo sapiens_hsa05010	1.89471685
16	Protein export_Homo sapiens_hsa03060	1.87453723
17	Huntingtons disease_Homo sapiens_hsa05016	1.83816030
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.82048516
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77246201
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.75082575
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.73725172
22	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.72877442
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.72135506
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.71729330
25	RNA degradation_Homo sapiens_hsa03018	1.68479989
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.63732591
27	Asthma_Homo sapiens_hsa05310	1.61684568
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.58869543
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53105925
30	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.47887830
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.43802822
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.37667420
33	Butanoate metabolism_Homo sapiens_hsa00650	1.33400899
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.29589139
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22783513
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.20617542
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.19801735
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19515872
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.18094831
40	Retinol metabolism_Homo sapiens_hsa00830	1.15247000
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14901915
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.14645832
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11319108
44	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11125823
45	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.05418063
46	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.00355398
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.92599472
48	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.87449228
49	RNA polymerase_Homo sapiens_hsa03020	0.83269902
50	Peroxisome_Homo sapiens_hsa04146	0.83043608
51	Regulation of autophagy_Homo sapiens_hsa04140	0.82027074
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81228946
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72963691
54	Measles_Homo sapiens_hsa05162	0.70099157
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65768060
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.65335386
57	Apoptosis_Homo sapiens_hsa04210	0.65169351
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63240218
59	Sulfur relay system_Homo sapiens_hsa04122	0.62811352
60	Olfactory transduction_Homo sapiens_hsa04740	0.56680968
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.53624454
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53574943
63	Phototransduction_Homo sapiens_hsa04744	0.52787999
64	p53 signaling pathway_Homo sapiens_hsa04115	0.52264009
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51415396
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49417244
67	ABC transporters_Homo sapiens_hsa02010	0.47030900
68	Metabolic pathways_Homo sapiens_hsa01100	0.46976589
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46576205
70	RNA transport_Homo sapiens_hsa03013	0.46526239
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42206312
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41939121
73	Malaria_Homo sapiens_hsa05144	0.40030326
74	Other glycan degradation_Homo sapiens_hsa00511	0.39494283
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38327408
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.37405069
77	Fatty acid elongation_Homo sapiens_hsa00062	0.37011869
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36983711
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36968257
80	Pertussis_Homo sapiens_hsa05133	0.36445693
81	Purine metabolism_Homo sapiens_hsa00230	0.35938461
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33843775
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33752180
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33595833
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.30823136
86	Galactose metabolism_Homo sapiens_hsa00052	0.27528528
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27013867
88	Caffeine metabolism_Homo sapiens_hsa00232	0.26527492
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24318467
90	Legionellosis_Homo sapiens_hsa05134	0.19296903
91	Glutathione metabolism_Homo sapiens_hsa00480	0.18933603
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.18855320
93	Histidine metabolism_Homo sapiens_hsa00340	0.16216591
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.15798375
95	Taste transduction_Homo sapiens_hsa04742	0.15255549
96	Nicotine addiction_Homo sapiens_hsa05033	0.14618251
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.14457209
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.13618262
99	Spliceosome_Homo sapiens_hsa03040	0.12383327
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.11913876

RPS3AP23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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