RPS3AP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of organelle assembly (GO:1902116)9.12254433
2atrial cardiac muscle cell action potential (GO:0086014)7.97812875
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.76398275
4kidney morphogenesis (GO:0060993)7.00956405
5positive regulation of respiratory burst (GO:0060267)6.84680763
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.78586252
7pseudouridine synthesis (GO:0001522)6.64357648
8gap junction assembly (GO:0016264)6.59172512
9positive regulation of antigen processing and presentation (GO:0002579)6.50177671
10urinary tract smooth muscle contraction (GO:0014848)6.40758790
11peristalsis (GO:0030432)6.31085057
12positive regulation of guanylate cyclase activity (GO:0031284)5.97900614
13DNA deamination (GO:0045006)5.93720335
14antigen processing and presentation of endogenous antigen (GO:0019883)5.69966925
15negative regulation of interleukin-1 beta production (GO:0032691)5.66534917
16regulation of guanylate cyclase activity (GO:0031282)5.40904087
17positive regulation of CREB transcription factor activity (GO:0032793)5.38921849
18postsynaptic membrane organization (GO:0001941)5.38544813
19growth hormone secretion (GO:0030252)5.20831898
20positive regulation of natural killer cell differentiation (GO:0032825)5.16101915
21arginine catabolic process (GO:0006527)5.15369213
22negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.90171375
23regulation of antigen processing and presentation (GO:0002577)4.84300732
24adult feeding behavior (GO:0008343)4.82781138
25regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.74238473
26cytidine metabolic process (GO:0046087)4.72030820
27cytidine catabolic process (GO:0006216)4.72030820
28cytidine deamination (GO:0009972)4.72030820
29pericardium development (GO:0060039)4.66933814
30negative regulation of interleukin-1 production (GO:0032692)4.57324576
31regulation of microtubule-based movement (GO:0060632)4.46094398
32sulfate transport (GO:0008272)4.45048610
33DNA-dependent DNA replication (GO:0006261)4.34929567
34response to xenobiotic stimulus (GO:0009410)4.30331202
35myotube differentiation (GO:0014902)4.29690642
36negative regulation of telomere maintenance (GO:0032205)4.17464957
37regulation of respiratory system process (GO:0044065)4.16282672
38piRNA metabolic process (GO:0034587)4.14173702
39tRNA methylation (GO:0030488)4.11613727
40pyrimidine ribonucleoside catabolic process (GO:0046133)4.04959039
41phasic smooth muscle contraction (GO:0014821)3.81999780
42dopaminergic neuron differentiation (GO:0071542)3.80709772
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.77233919
44positive regulation of cGMP biosynthetic process (GO:0030828)3.75009798
45regulation of cilium assembly (GO:1902017)3.74416984
46multicellular organismal movement (GO:0050879)3.73137390
47musculoskeletal movement (GO:0050881)3.73137390
48positive regulation of sodium ion transmembrane transport (GO:1902307)3.72697329
49regulation of beta-amyloid formation (GO:1902003)3.67952613
50negative regulation of telomerase activity (GO:0051974)3.66823132
51vocalization behavior (GO:0071625)3.64650942
52drinking behavior (GO:0042756)3.58836025
53regulation of respiratory burst (GO:0060263)3.53093840
54arginine metabolic process (GO:0006525)3.51517301
55presynaptic membrane assembly (GO:0097105)3.51411678
56dermatan sulfate biosynthetic process (GO:0030208)3.51395099
57regulation of cGMP biosynthetic process (GO:0030826)3.50743087
58regulation of interleukin-6 biosynthetic process (GO:0045408)3.50626691
59regulation of respiratory gaseous exchange (GO:0043576)3.49346759
60regulation of natural killer cell differentiation (GO:0032823)3.47321996
61aldehyde catabolic process (GO:0046185)3.36605224
62regulation of histone phosphorylation (GO:0033127)3.34890430
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31193032
64positive regulation of cGMP metabolic process (GO:0030825)3.30569905
65primary alcohol catabolic process (GO:0034310)3.27212027
66response to nitrosative stress (GO:0051409)3.25529311
67DNA methylation involved in gamete generation (GO:0043046)3.25220152
68behavioral response to nicotine (GO:0035095)3.20311240
69regulation of cGMP metabolic process (GO:0030823)3.20270117
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17375956
71regulation of response to food (GO:0032095)3.14416152
72neuron cell-cell adhesion (GO:0007158)3.13504912
73positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.09411370
74dermatan sulfate metabolic process (GO:0030205)3.07980414
75maturation of 5.8S rRNA (GO:0000460)3.06061473
76regulation of telomere maintenance via telomerase (GO:0032210)3.01059903
77positive regulation of mast cell activation (GO:0033005)2.99605764
78regulation of mesoderm development (GO:2000380)2.98899909
79endosome to melanosome transport (GO:0035646)2.98662648
80endosome to pigment granule transport (GO:0043485)2.98662648
81exogenous drug catabolic process (GO:0042738)2.97961850
82negative regulation of blood pressure (GO:0045776)2.95647915
83presynaptic membrane organization (GO:0097090)2.90946731
84positive regulation of fatty acid metabolic process (GO:0045923)2.89679144
85embryonic foregut morphogenesis (GO:0048617)2.89228948
86response to redox state (GO:0051775)2.88320502
87regulation of telomere maintenance (GO:0032204)2.85378268
88histone H2A monoubiquitination (GO:0035518)2.84698397
89hormone catabolic process (GO:0042447)2.82747526
90protein polyglutamylation (GO:0018095)2.81174500
91rRNA catabolic process (GO:0016075)2.79855880
92positive regulation of peptidyl-lysine acetylation (GO:2000758)2.79476031
93positive regulation of protein acetylation (GO:1901985)2.79476031
94positive regulation of defense response to virus by host (GO:0002230)2.77831544
95regulation of amyloid precursor protein catabolic process (GO:1902991)2.72204427
96serotonin receptor signaling pathway (GO:0007210)2.71655978
97positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.70952380
98lysine metabolic process (GO:0006553)2.70782196
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)11.9874318
100antigen processing and presentation via MHC class Ib (GO:0002475)10.0488760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human8.67367165
2ZNF274_21170338_ChIP-Seq_K562_Hela4.67363270
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.24279351
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23989526
5EZH2_22144423_ChIP-Seq_EOC_Human3.17274427
6VDR_22108803_ChIP-Seq_LS180_Human2.56350866
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55961978
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.48981646
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.40213214
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40213214
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33525533
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23683059
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.22411787
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.16828851
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15977161
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.03069167
17REST_21632747_ChIP-Seq_MESCs_Mouse2.01833830
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99261953
19ERA_21632823_ChIP-Seq_H3396_Human1.86308973
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85355986
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.80337547
22GATA3_21878914_ChIP-Seq_MCF-7_Human1.77469222
23RNF2_27304074_Chip-Seq_NSC_Mouse1.76007290
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72817081
25FUS_26573619_Chip-Seq_HEK293_Human1.71100521
26MYC_19829295_ChIP-Seq_ESCs_Human1.70744127
27ER_23166858_ChIP-Seq_MCF-7_Human1.68343388
28AR_21572438_ChIP-Seq_LNCaP_Human1.65511265
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58487099
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57356901
31TP53_22573176_ChIP-Seq_HFKS_Human1.57329900
32HOXB7_26014856_ChIP-Seq_BT474_Human1.55079006
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50659027
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.49855522
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.47824562
36IRF1_19129219_ChIP-ChIP_H3396_Human1.46087576
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45532435
38FOXH1_21741376_ChIP-Seq_EPCs_Human1.45205155
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42683570
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35802845
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35249505
42TCF4_23295773_ChIP-Seq_U87_Human1.34976681
43TP53_16413492_ChIP-PET_HCT116_Human1.33562590
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33458548
45NANOG_20526341_ChIP-Seq_ESCs_Human1.31922427
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.31686691
47STAT3_23295773_ChIP-Seq_U87_Human1.31569970
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30842139
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.29932718
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29932718
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.28500561
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23532854
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23042405
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22451421
55OCT1_27270436_Chip-Seq_PROSTATE_Human1.20374031
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19165235
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18992526
58EWS_26573619_Chip-Seq_HEK293_Human1.17837876
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15962028
60TAF2_19829295_ChIP-Seq_ESCs_Human1.14698582
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13722447
62P300_19829295_ChIP-Seq_ESCs_Human1.13025319
63GATA3_26560356_Chip-Seq_TH2_Human1.12733950
64AR_25329375_ChIP-Seq_VCAP_Human1.12508762
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11381845
66CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11220217
67DROSHA_22980978_ChIP-Seq_HELA_Human1.10990949
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10909428
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10425787
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08406260
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.07710420
72P53_21459846_ChIP-Seq_SAOS-2_Human1.07016504
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04461890
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03454705
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01632060
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01378772
77RARB_24833708_ChIP-Seq_LIVER_Mouse1.01135376
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00963259
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.00945174
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00794265
81FOXH1_21741376_ChIP-Seq_ESCs_Human1.00075099
82SPI1_20517297_ChIP-Seq_HL60_Human0.99773343
83GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99596391
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96924960
85RAC3_21632823_ChIP-Seq_H3396_Human0.96036259
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95883311
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94409693
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93825008
89AR_20517297_ChIP-Seq_VCAP_Human0.93628926
90SOX2_19829295_ChIP-Seq_ESCs_Human0.93495080
91NANOG_19829295_ChIP-Seq_ESCs_Human0.93495080
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93035147
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.92166793
94CTCF_20526341_ChIP-Seq_ESCs_Human0.91977167
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.91911747
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.91078622
97EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90493350
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90493350
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89688806
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89189651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level8.94148467
2MP0001348_abnormal_lacrimal_gland6.59228993
3MP0003646_muscle_fatigue5.12753469
4MP0005167_abnormal_blood-brain_barrier5.04783372
5MP0002735_abnormal_chemical_nociception3.87672369
6MP0001849_ear_inflammation3.13954029
7MP0004043_abnormal_pH_regulation2.97105531
8MP0009840_abnormal_foam_cell2.83569588
9MP0005645_abnormal_hypothalamus_physiol2.44291817
10MP0003195_calcinosis2.35971898
11MP0008872_abnormal_physiological_respon2.28000462
12MP0009697_abnormal_copulation2.15517756
13MP0003137_abnormal_impulse_conducting2.07105416
14MP0002822_catalepsy1.82225496
15MP0002254_reproductive_system_inflammat1.76670305
16MP0003718_maternal_effect1.71347895
17MP0004084_abnormal_cardiac_muscle1.70228331
18MP0002733_abnormal_thermal_nociception1.70168238
19MP0003950_abnormal_plasma_membrane1.66346989
20MP0001970_abnormal_pain_threshold1.60896843
21MP0004185_abnormal_adipocyte_glucose1.48169688
22MP0008775_abnormal_heart_ventricle1.43234243
23MP0009046_muscle_twitch1.39787393
24MP0002102_abnormal_ear_morphology1.37662297
25MP0002734_abnormal_mechanical_nocicepti1.36340427
26MP0004782_abnormal_surfactant_physiolog1.36010325
27MP0000230_abnormal_systemic_arterial1.35483752
28MP0004924_abnormal_behavior1.29688784
29MP0005386_behavior/neurological_phenoty1.29688784
30MP0005360_urolithiasis1.27986717
31MP0008877_abnormal_DNA_methylation1.27928163
32MP0008057_abnormal_DNA_replication1.27697777
33MP0005551_abnormal_eye_electrophysiolog1.23713442
34MP0002938_white_spotting1.23502376
35MP0009745_abnormal_behavioral_response1.21721376
36MP0003638_abnormal_response/metabolism_1.16543414
37MP0002638_abnormal_pupillary_reflex1.14276412
38MP0004085_abnormal_heartbeat1.08859257
39MP0008875_abnormal_xenobiotic_pharmacok1.06535944
40MP0003329_amyloid_beta_deposits1.04840492
41MP0001501_abnormal_sleep_pattern1.03583210
42MP0003806_abnormal_nucleotide_metabolis1.02825680
43MP0001177_atelectasis0.99803575
44MP0002234_abnormal_pharynx_morphology0.99292220
45MP0002837_dystrophic_cardiac_calcinosis0.98373445
46MP0001486_abnormal_startle_reflex0.97692637
47MP0005646_abnormal_pituitary_gland0.94595753
48MP0001851_eye_inflammation0.94385614
49MP0004885_abnormal_endolymph0.93196312
50MP0001905_abnormal_dopamine_level0.93106191
51MP0003045_fibrosis0.92255202
52MP0004130_abnormal_muscle_cell0.92057567
53MP0005448_abnormal_energy_balance0.91656512
54MP0001440_abnormal_grooming_behavior0.89296366
55MP0002572_abnormal_emotion/affect_behav0.87018969
56MP0002063_abnormal_learning/memory/cond0.86956699
57MP0000383_abnormal_hair_follicle0.86949541
58MP0002272_abnormal_nervous_system0.86557219
59MP0004859_abnormal_synaptic_plasticity0.85681219
60MP0000538_abnormal_urinary_bladder0.82523662
61MP0006292_abnormal_olfactory_placode0.79953425
62MP0005253_abnormal_eye_physiology0.78786993
63MP0003635_abnormal_synaptic_transmissio0.77868108
64MP0009764_decreased_sensitivity_to0.77229615
65MP0002557_abnormal_social/conspecific_i0.74961765
66MP0001663_abnormal_digestive_system0.72614255
67MP0000681_abnormal_thyroid_gland0.72257875
68MP0004133_heterotaxia0.70831257
69MP0000534_abnormal_ureter_morphology0.70384636
70MP0002132_abnormal_respiratory_system0.69556971
71MP0005266_abnormal_metabolism0.68950853
72MP0002067_abnormal_sensory_capabilities0.67331852
73MP0002064_seizures0.67232326
74MP0009250_abnormal_appendicular_skeleto0.65001735
75MP0002876_abnormal_thyroid_physiology0.64963621
76MP0010329_abnormal_lipoprotein_level0.64601189
77MP0003890_abnormal_embryonic-extraembry0.64216587
78MP0003315_abnormal_perineum_morphology0.63500336
79MP0005410_abnormal_fertilization0.63272906
80MP0004742_abnormal_vestibular_system0.61677270
81MP0004036_abnormal_muscle_relaxation0.61613046
82MP0003119_abnormal_digestive_system0.60845903
83MP0002184_abnormal_innervation0.59941223
84MP0005535_abnormal_body_temperature0.59606723
85MP0004858_abnormal_nervous_system0.59503341
86MP0003186_abnormal_redox_activity0.59460773
87MP0005395_other_phenotype0.59381527
88MP0003693_abnormal_embryo_hatching0.58453430
89MP0003633_abnormal_nervous_system0.57293481
90MP0002127_abnormal_cardiovascular_syste0.55178915
91MP0005195_abnormal_posterior_eye0.54976960
92MP0000566_synostosis0.54119586
93MP0001984_abnormal_olfaction0.50048098
94MP0005332_abnormal_amino_acid0.49245858
95MP0003942_abnormal_urinary_system0.48777015
96MP0002933_joint_inflammation0.47537138
97MP0003943_abnormal_hepatobiliary_system0.46903931
98MP0000604_amyloidosis0.46558046
99MP0003656_abnormal_erythrocyte_physiolo0.45916548
100MP0000427_abnormal_hair_cycle0.45429284

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the sternum (HP:0006714)6.68536954
2Microretrognathia (HP:0000308)6.67703497
3Diastasis recti (HP:0001540)6.24324792
4Long foot (HP:0001833)5.31521963
5Myokymia (HP:0002411)5.17640892
6Patellar aplasia (HP:0006443)5.02944772
7Hyperventilation (HP:0002883)4.88482069
8Type II lissencephaly (HP:0007260)4.75413114
9Aplasia/Hypoplasia of the patella (HP:0006498)4.71190313
10Large eyes (HP:0001090)4.45147093
11Slender long bone (HP:0003100)4.11438203
12Poor speech (HP:0002465)4.10891773
13Depressed nasal tip (HP:0000437)3.78442020
14Lissencephaly (HP:0001339)3.67240555
15Breast aplasia (HP:0100783)3.52986704
16Nasal speech (HP:0001611)3.41950624
17Abnormality of the clitoris (HP:0000056)3.29847963
18Scrotal hypoplasia (HP:0000046)3.29371020
19Coxa vara (HP:0002812)3.27776662
20Aplasia/Hypoplasia of the breasts (HP:0010311)3.26753176
21Microtia (HP:0008551)3.23516221
22Genu varum (HP:0002970)3.20517072
23Pancreatic cysts (HP:0001737)3.06396775
24Aplasia/Hypoplasia involving the musculature (HP:0001460)3.05703402
25Hypoplasia of the maxilla (HP:0000327)3.03595572
26Congenital stationary night blindness (HP:0007642)3.03072339
27Poor head control (HP:0002421)2.89905595
28Nephronophthisis (HP:0000090)2.87938866
29Macroorchidism (HP:0000053)2.79197259
30Retinal dysplasia (HP:0007973)2.77642604
31Pancreatic fibrosis (HP:0100732)2.76525084
32Molar tooth sign on MRI (HP:0002419)2.74476742
33Abnormality of midbrain morphology (HP:0002418)2.74476742
34Protruding tongue (HP:0010808)2.73661051
35Inability to walk (HP:0002540)2.72171765
36Chorioretinal atrophy (HP:0000533)2.69562085
37Abnormality of the fingertips (HP:0001211)2.68017067
38Recurrent pneumonia (HP:0006532)2.56303612
39Hip dysplasia (HP:0001385)2.55736677
40Anterior segment dysgenesis (HP:0007700)2.51016053
41Female pseudohermaphroditism (HP:0010458)2.49446718
42Abnormality of the renal medulla (HP:0100957)2.43301118
43True hermaphroditism (HP:0010459)2.42799837
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36678993
45Abnormal respiratory motile cilium morphology (HP:0005938)2.30699355
46Abnormal respiratory epithelium morphology (HP:0012253)2.30699355
47Abnormality of the vitreous humor (HP:0004327)2.29689199
48Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25688417
49Hypoplasia of the brainstem (HP:0002365)2.25688417
50Partial agenesis of the corpus callosum (HP:0001338)2.18787646
51Short ribs (HP:0000773)2.16635176
52Widely spaced teeth (HP:0000687)2.12795179
53Cerebellar dysplasia (HP:0007033)2.12663067
54Global brain atrophy (HP:0002283)2.12521478
55Abnormality of the renal cortex (HP:0011035)2.10969140
56Gait imbalance (HP:0002141)2.09291718
57Atresia of the external auditory canal (HP:0000413)2.06862881
58Increased density of long bones (HP:0006392)2.06007038
59Spondylolisthesis (HP:0003302)2.05793950
60Broad-based gait (HP:0002136)2.04580405
61Pendular nystagmus (HP:0012043)2.01254102
62Birth length less than 3rd percentile (HP:0003561)14.5932629
63Breast hypoplasia (HP:0003187)10.2441028
64Spastic tetraparesis (HP:0001285)1.96160702
65Pigmentary retinal degeneration (HP:0001146)1.94725449
66Abnormal ciliary motility (HP:0012262)1.93630076
67Long nose (HP:0003189)1.89227506
68Recurrent lower respiratory tract infections (HP:0002783)1.88594873
69Chronic mucocutaneous candidiasis (HP:0002728)1.86544124
70Recurrent cutaneous fungal infections (HP:0011370)1.86544124
71Non-midline cleft lip (HP:0100335)1.85410360
72Craniofacial dystonia (HP:0012179)1.81470924
73Congenital primary aphakia (HP:0007707)1.78198093
74Increased corneal curvature (HP:0100692)1.75643297
75Keratoconus (HP:0000563)1.75643297
76Abnormality of the pons (HP:0007361)1.74050893
77Muscular dystrophy (HP:0003560)1.72355288
78Cystic liver disease (HP:0006706)1.68280372
79Medial flaring of the eyebrow (HP:0010747)1.68123493
80Large for gestational age (HP:0001520)1.67688996
81Decreased muscle mass (HP:0003199)1.67263517
82Focal dystonia (HP:0004373)1.66095524
83Optic nerve hypoplasia (HP:0000609)1.65872574
84Dandy-Walker malformation (HP:0001305)1.64352329
85Torticollis (HP:0000473)1.63301899
86Abnormality of the metopic suture (HP:0005556)1.61920709
87Nephrogenic diabetes insipidus (HP:0009806)1.60894271
88Tubular atrophy (HP:0000092)1.59581230
89Cerebellar hypoplasia (HP:0001321)1.59088095
90Prominent metopic ridge (HP:0005487)1.58294702
91Prominent nasal bridge (HP:0000426)1.58073166
92Bulbous nose (HP:0000414)1.57770195
93Akinesia (HP:0002304)1.55085674
94Hypotelorism (HP:0000601)1.54115590
95Abnormality of DNA repair (HP:0003254)1.51990527
96Pachygyria (HP:0001302)1.51353521
97Hypobetalipoproteinemia (HP:0003563)1.51105273
98Attenuation of retinal blood vessels (HP:0007843)1.50739314
99Abolished electroretinogram (ERG) (HP:0000550)1.50574891
100Prominent forehead (HP:0011220)1.50464147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.31783952
2BMPR1B6.44464337
3DAPK25.43085199
4CASK4.80691661
5CAMKK13.59966238
6TGFBR13.37635829
7NME13.08351930
8ZAK2.72731364
9NEK92.30458945
10CAMK1D1.93781539
11STK38L1.89624893
12FRK1.72967641
13WNK41.67960801
14SIK21.52689555
15MKNK21.48843444
16NEK21.45854130
17CAMKK21.39906091
18MAP3K71.36291144
19MKNK11.33385556
20ADRBK11.29908567
21ADRBK21.29322932
22PTK2B1.28575900
23CAMK1G1.21919188
24MAP2K61.19599936
25MELK1.13110169
26TAOK31.10504478
27NTRK21.10483022
28WNK30.94640397
29MAPK130.93836357
30CAMK10.93608420
31PRKG20.87461538
32WNK10.84539503
33MAP2K10.83101653
34MARK10.82605472
35CAMK40.80998621
36TLK10.78434108
37PHKG10.69454315
38PHKG20.69454315
39CAMK2A0.67835435
40PIK3CA0.67819662
41GRK70.64457071
42TIE10.62894181
43TRIB30.60094979
44ABL20.59852433
45NUAK10.59518300
46RPS6KA60.53020335
47MAPKAPK50.51348843
48NEK10.48743709
49STK380.46072206
50GRK10.43624896
51PRKAA20.42585751
52PINK10.39432221
53CSF1R0.39405323
54BCKDK0.38097353
55TNIK0.37700295
56NTRK30.35695903
57PAK30.34316724
58PKN10.34202959
59BMX0.32587901
60PRKCI0.32373104
61FGR0.32189881
62MET0.31416061
63ALK0.31267364
64RPS6KA50.29857066
65PRKAA10.27915302
66KIT0.26407635
67PAK60.26380728
68IKBKB0.25847278
69CSNK1A10.24567904
70PRKCZ0.23519826
71PRKCQ0.22541862
72SYK0.22114215
73PRKCH0.19867449
74MAPKAPK30.19481132
75PRKACG0.19459537
76MST1R0.19277016
77TXK0.18371615
78MAP3K130.17021699
79PRKCG0.15505348
80PLK10.13833296
81CHUK0.13576913
82PLK30.12636641
83LYN0.12490194
84PRKD20.10319682
85DYRK20.09799120
86PRKACB0.09298002
87IGF1R0.09114829
88CDK10.08914621
89PRKACA0.08494166
90VRK10.07526686
91RPS6KA30.07499200
92CHEK20.06570408
93CSNK2A10.05471593
94PTK60.04387378
95MAP3K40.04335820
96INSRR0.03925450
97TNK20.03402773
98PRKDC0.02513410
99RPS6KL10.02359731
100RPS6KC10.02359731

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020104.08257980
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.77044679
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67276187
4Linoleic acid metabolism_Homo sapiens_hsa005912.64085511
5Phototransduction_Homo sapiens_hsa047442.49959614
6Nitrogen metabolism_Homo sapiens_hsa009102.48544635
7Fatty acid biosynthesis_Homo sapiens_hsa000612.28474716
8Arginine biosynthesis_Homo sapiens_hsa002202.27409850
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.26132198
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.10777511
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06813246
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.06044039
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04808649
14Nucleotide excision repair_Homo sapiens_hsa034202.03297435
15Butanoate metabolism_Homo sapiens_hsa006501.96698811
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95999824
17Tyrosine metabolism_Homo sapiens_hsa003501.69038240
18Serotonergic synapse_Homo sapiens_hsa047261.60526719
19Glycerolipid metabolism_Homo sapiens_hsa005611.59742583
20Nicotine addiction_Homo sapiens_hsa050331.56893421
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.51020020
22Asthma_Homo sapiens_hsa053101.50533458
23GABAergic synapse_Homo sapiens_hsa047271.44023060
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44016291
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42376492
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39484730
27Arginine and proline metabolism_Homo sapiens_hsa003301.39237229
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36952440
29Cell cycle_Homo sapiens_hsa041101.28009400
30Ovarian steroidogenesis_Homo sapiens_hsa049131.23591158
31beta-Alanine metabolism_Homo sapiens_hsa004101.15933666
32Tryptophan metabolism_Homo sapiens_hsa003801.15777424
33Long-term depression_Homo sapiens_hsa047301.13788683
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13262709
35Arachidonic acid metabolism_Homo sapiens_hsa005901.08155541
36Chemical carcinogenesis_Homo sapiens_hsa052041.07909909
37Ether lipid metabolism_Homo sapiens_hsa005651.05810631
38Propanoate metabolism_Homo sapiens_hsa006401.05761974
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01742458
40Oxytocin signaling pathway_Homo sapiens_hsa049211.01733288
41Base excision repair_Homo sapiens_hsa034101.00596737
42RNA degradation_Homo sapiens_hsa030180.99328171
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94574712
44Bladder cancer_Homo sapiens_hsa052190.94026934
45Morphine addiction_Homo sapiens_hsa050320.93982154
46DNA replication_Homo sapiens_hsa030300.93733021
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92883304
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92845776
49Sulfur relay system_Homo sapiens_hsa041220.91950870
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.89631898
51Homologous recombination_Homo sapiens_hsa034400.89031077
52Calcium signaling pathway_Homo sapiens_hsa040200.88859872
53Fatty acid degradation_Homo sapiens_hsa000710.88591923
54Vitamin digestion and absorption_Homo sapiens_hsa049770.83399409
55Autoimmune thyroid disease_Homo sapiens_hsa053200.83144902
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81671048
57Caffeine metabolism_Homo sapiens_hsa002320.80530771
58Non-homologous end-joining_Homo sapiens_hsa034500.78772175
59Thyroid hormone synthesis_Homo sapiens_hsa049180.77469045
60Glutamatergic synapse_Homo sapiens_hsa047240.76263342
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75708253
62Vitamin B6 metabolism_Homo sapiens_hsa007500.72807525
63Mineral absorption_Homo sapiens_hsa049780.72685670
64Hematopoietic cell lineage_Homo sapiens_hsa046400.72264036
65Graft-versus-host disease_Homo sapiens_hsa053320.71727606
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.69866839
67Staphylococcus aureus infection_Homo sapiens_hsa051500.69673674
68Peroxisome_Homo sapiens_hsa041460.69664054
69Fat digestion and absorption_Homo sapiens_hsa049750.69561535
70Platelet activation_Homo sapiens_hsa046110.69216177
71VEGF signaling pathway_Homo sapiens_hsa043700.69009536
72Histidine metabolism_Homo sapiens_hsa003400.68327685
73Allograft rejection_Homo sapiens_hsa053300.67925179
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67853107
75Fanconi anemia pathway_Homo sapiens_hsa034600.66159244
76Insulin secretion_Homo sapiens_hsa049110.63159832
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.61590910
78Retinol metabolism_Homo sapiens_hsa008300.60987784
79Gastric acid secretion_Homo sapiens_hsa049710.60804520
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.59779232
81Bile secretion_Homo sapiens_hsa049760.57848519
82Olfactory transduction_Homo sapiens_hsa047400.56541326
83Basal transcription factors_Homo sapiens_hsa030220.56198880
84Dorso-ventral axis formation_Homo sapiens_hsa043200.54563159
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54511862
86Circadian entrainment_Homo sapiens_hsa047130.51240947
87Protein export_Homo sapiens_hsa030600.50965873
88Salivary secretion_Homo sapiens_hsa049700.50564377
89One carbon pool by folate_Homo sapiens_hsa006700.50386019
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49746768
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46504511
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44477470
93Lysosome_Homo sapiens_hsa041420.42942330
94Selenocompound metabolism_Homo sapiens_hsa004500.42306899
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37923855
96p53 signaling pathway_Homo sapiens_hsa041150.37822619
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36520949
98Type I diabetes mellitus_Homo sapiens_hsa049400.36203797
99Metabolic pathways_Homo sapiens_hsa011000.35948352
100RNA transport_Homo sapiens_hsa030130.33438503

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