ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.84627941
2	viral transcription (GO:0019083)	5.11541933
3	DNA deamination (GO:0045006)	5.05188562
4	translational termination (GO:0006415)	4.96071592
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.56663936
6	ATP synthesis coupled proton transport (GO:0015986)	4.56663936
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.52126139
8	ribosomal large subunit biogenesis (GO:0042273)	4.47787924
9	translational elongation (GO:0006414)	4.39821824
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.32435627
11	cotranslational protein targeting to membrane (GO:0006613)	4.22455457
12	protein targeting to ER (GO:0045047)	4.21344063
13	protein localization to endoplasmic reticulum (GO:0070972)	4.02200498
14	cytidine metabolic process (GO:0046087)	3.99962699
15	cytidine catabolic process (GO:0006216)	3.99962699
16	cytidine deamination (GO:0009972)	3.99962699
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.99260845
18	viral life cycle (GO:0019058)	3.60390319
19	cellular protein complex disassembly (GO:0043624)	3.59912855
20	maturation of SSU-rRNA (GO:0030490)	3.57109780
21	ribosomal small subunit biogenesis (GO:0042274)	3.55007160
22	protein neddylation (GO:0045116)	3.50083475
23	translational initiation (GO:0006413)	3.48425570
24	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.47354044
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.47236953
26	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.46768080
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.41500478
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.41500478
29	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.36443718
30	behavioral response to nicotine (GO:0035095)	3.35717243
31	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.32628824
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31722205
33	protein complex biogenesis (GO:0070271)	3.12472794
34	electron transport chain (GO:0022900)	3.08850497
35	respiratory electron transport chain (GO:0022904)	3.08620809
36	translation (GO:0006412)	3.03223829
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01365283
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01365283
39	NADH dehydrogenase complex assembly (GO:0010257)	3.01365283
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98192606
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97140903
42	positive regulation of interleukin-17 production (GO:0032740)	2.94117930
43	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.91818052
44	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.90754675
45	protein complex disassembly (GO:0043241)	2.86014938
46	indole-containing compound catabolic process (GO:0042436)	2.82931399
47	indolalkylamine catabolic process (GO:0046218)	2.82931399
48	tryptophan catabolic process (GO:0006569)	2.82931399
49	macromolecular complex disassembly (GO:0032984)	2.81606496
50	proteasome assembly (GO:0043248)	2.78298718
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.73825216
52	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.73684645
53	negative regulation of mast cell activation (GO:0033004)	2.73502992
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70828906
55	response to pheromone (GO:0019236)	2.70390694
56	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.70151776
57	base-excision repair, AP site formation (GO:0006285)	2.69478140
58	purine deoxyribonucleotide catabolic process (GO:0009155)	2.68638953
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.67970905
60	detection of light stimulus involved in visual perception (GO:0050908)	2.67970905
61	protein targeting to membrane (GO:0006612)	2.67377379
62	kynurenine metabolic process (GO:0070189)	2.65695062
63	GTP biosynthetic process (GO:0006183)	2.64947309
64	platelet dense granule organization (GO:0060155)	2.64626413
65	piRNA metabolic process (GO:0034587)	2.64223581
66	GPI anchor metabolic process (GO:0006505)	2.57969435
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.57840557
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.57661580
69	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.57171840
70	GPI anchor biosynthetic process (GO:0006506)	2.56933329
71	deoxyribonucleotide catabolic process (GO:0009264)	2.56920806
72	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.55843903
73	negative regulation of heart rate (GO:0010459)	2.55730497
74	ATP biosynthetic process (GO:0006754)	2.55360823
75	aggressive behavior (GO:0002118)	2.55120127
76	purine nucleotide salvage (GO:0032261)	2.55008952
77	axoneme assembly (GO:0035082)	2.54483888
78	deoxyribose phosphate catabolic process (GO:0046386)	2.53873720
79	water-soluble vitamin biosynthetic process (GO:0042364)	2.49502541
80	positive regulation of defense response to virus by host (GO:0002230)	2.48958978
81	indolalkylamine metabolic process (GO:0006586)	2.48133298
82	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.47530528
83	cellular component biogenesis (GO:0044085)	2.47486334
84	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.47138092
85	mast cell activation (GO:0045576)	2.46228049
86	negative regulation of response to food (GO:0032096)	2.45571601
87	negative regulation of appetite (GO:0032099)	2.45571601
88	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.43097789
89	organelle disassembly (GO:1903008)	2.42567578
90	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.42502225
91	mRNA catabolic process (GO:0006402)	2.42444874
92	xenobiotic catabolic process (GO:0042178)	2.40629045
93	aldehyde catabolic process (GO:0046185)	2.39605063
94	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.39193867
95	regulation of action potential (GO:0098900)	2.39013540
96	immunoglobulin mediated immune response (GO:0016064)	2.38683923
97	ribonucleoprotein complex biogenesis (GO:0022613)	2.38588558
98	iron-sulfur cluster assembly (GO:0016226)	2.37977548
99	metallo-sulfur cluster assembly (GO:0031163)	2.37977548
100	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.37319529

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.63798066
2	VDR_22108803_ChIP-Seq_LS180_Human	3.45970699
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.43275638
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.04156940
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.92935774
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84072033
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.64996393
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.44455014
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41175766
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37738402
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.32492483
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.26657118
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.25768847
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16723839
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.12827020
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.09097005
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.04473254
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.90728606
19	FUS_26573619_Chip-Seq_HEK293_Human	1.90145033
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.78573947
21	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.75037126
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73850789
23	EWS_26573619_Chip-Seq_HEK293_Human	1.72787620
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70149739
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64139563
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.62891767
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61100395
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.57754458
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57545274
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.56837487
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56827860
32	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54222905
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54222905
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.54162422
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47894887
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.47583143
37	AR_20517297_ChIP-Seq_VCAP_Human	1.47478753
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.44755610
39	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.44614046
40	GATA3_26560356_Chip-Seq_TH2_Human	1.40682991
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39217066
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39159617
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35593092
44	NCOR_22424771_ChIP-Seq_293T_Human	1.35137014
45	P300_19829295_ChIP-Seq_ESCs_Human	1.32474661
46	MYB_26560356_Chip-Seq_TH2_Human	1.32088286
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.31229302
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31229302
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30223404
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29026325
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29026325
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28421537
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27874694
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27512262
55	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25592248
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24569103
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.23928509
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23612105
59	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.23571250
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23490835
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22646538
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22334474
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22260558
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21908327
65	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.21323413
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21307775
67	RUNX_20019798_ChIP-Seq_JUKART_Human	1.20684652
68	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.20468215
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14410491
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13218986
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12858222
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10980245
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08270535
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.07615597
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07611457
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07557542
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.06865042
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04969753
79	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.04941636
80	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04904052
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.03396397
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02863022
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02633690
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01481454
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01283181
86	GATA3_27048872_Chip-Seq_THYMUS_Human	0.99995972
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.97525031
88	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96901250
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96650182
90	TAF15_26573619_Chip-Seq_HEK293_Human	0.95754805
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95532551
92	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94275117
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93237745
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92522447
95	ERA_21632823_ChIP-Seq_H3396_Human	0.92229711
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.91437674
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91051980
98	GATA1_22025678_ChIP-Seq_K562_Human	0.90892576
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.88784111
100	SCL_19346495_ChIP-Seq_HPC-7_Human	0.88470863

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.92354842
2	MP0005671_abnormal_response_to	3.28456608
3	MP0001835_abnormal_antigen_presentation	3.11198339
4	MP0006292_abnormal_olfactory_placode	2.99540501
5	MP0002102_abnormal_ear_morphology	2.36619323
6	MP0005645_abnormal_hypothalamus_physiol	2.22661590
7	MP0002837_dystrophic_cardiac_calcinosis	2.18446543
8	MP0005646_abnormal_pituitary_gland	2.11941489
9	MP0004147_increased_porphyrin_level	2.08598631
10	MP0003646_muscle_fatigue	2.08250594
11	MP0008872_abnormal_physiological_respon	2.08178994
12	MP0006072_abnormal_retinal_apoptosis	2.04440476
13	MP0008877_abnormal_DNA_methylation	2.04370711
14	MP0001873_stomach_inflammation	2.00707197
15	MP0009785_altered_susceptibility_to	1.90488546
16	MP0002148_abnormal_hypersensitivity_rea	1.89431377
17	MP0001800_abnormal_humoral_immune	1.84790770
18	MP0002138_abnormal_hepatobiliary_system	1.81593668
19	MP0005551_abnormal_eye_electrophysiolog	1.80993507
20	MP0009333_abnormal_splenocyte_physiolog	1.71086326
21	MP0001968_abnormal_touch/_nociception	1.65618596
22	MP0001986_abnormal_taste_sensitivity	1.63185607
23	MP0008875_abnormal_xenobiotic_pharmacok	1.62514945
24	MP0005000_abnormal_immune_tolerance	1.61468913
25	MP0003763_abnormal_thymus_physiology	1.46528489
26	MP0005387_immune_system_phenotype	1.44730669
27	MP0001790_abnormal_immune_system	1.44730669
28	MP0005389_reproductive_system_phenotype	1.43701231
29	MP0002723_abnormal_immune_serum	1.43505042
30	MP0005075_abnormal_melanosome_morpholog	1.42766669
31	MP0003878_abnormal_ear_physiology	1.42668331
32	MP0005377_hearing/vestibular/ear_phenot	1.42668331
33	MP0004885_abnormal_endolymph	1.41910012
34	MP0000372_irregular_coat_pigmentation	1.40725297
35	MP0004145_abnormal_muscle_electrophysio	1.40332138
36	MP0002166_altered_tumor_susceptibility	1.40193749
37	MP0005084_abnormal_gallbladder_morpholo	1.38675871
38	MP0000685_abnormal_immune_system	1.36972646
39	MP0003787_abnormal_imprinting	1.36012213
40	MP0002160_abnormal_reproductive_system	1.35686630
41	MP0004142_abnormal_muscle_tone	1.35418110
42	MP0002736_abnormal_nociception_after	1.34590626
43	MP0003806_abnormal_nucleotide_metabolis	1.34472313
44	MP0005360_urolithiasis	1.34136756
45	MP0002420_abnormal_adaptive_immunity	1.33891849
46	MP0002234_abnormal_pharynx_morphology	1.33673336
47	MP0001819_abnormal_immune_cell	1.32450133
48	MP0001764_abnormal_homeostasis	1.32150034
49	MP0002452_abnormal_antigen_presenting	1.31603343
50	MP0003724_increased_susceptibility_to	1.27572143
51	MP0005025_abnormal_response_to	1.25578126
52	MP0002006_tumorigenesis	1.24713955
53	MP0000678_abnormal_parathyroid_gland	1.18350058
54	MP0001905_abnormal_dopamine_level	1.17436419
55	MP0001485_abnormal_pinna_reflex	1.14095086
56	MP0005253_abnormal_eye_physiology	1.14068224
57	MP0006276_abnormal_autonomic_nervous	1.13496633
58	MP0001919_abnormal_reproductive_system	1.09382101
59	MP0001765_abnormal_ion_homeostasis	1.05521414
60	MP0003195_calcinosis	1.03697176
61	MP0001664_abnormal_digestion	1.03597664
62	MP0000716_abnormal_immune_system	1.03466618
63	MP0010155_abnormal_intestine_physiology	1.02723728
64	MP0002398_abnormal_bone_marrow	1.02421598
65	MP0009764_decreased_sensitivity_to	1.02304070
66	MP0008995_early_reproductive_senescence	1.01940664
67	MP0002272_abnormal_nervous_system	1.01432870
68	MP0003880_abnormal_central_pattern	1.01420923
69	MP0005636_abnormal_mineral_homeostasis	0.99501084
70	MP0003866_abnormal_defecation	0.99374169
71	MP0008789_abnormal_olfactory_epithelium	0.98190958
72	MP0002876_abnormal_thyroid_physiology	0.97215868
73	MP0002095_abnormal_skin_pigmentation	0.97189759
74	MP0002405_respiratory_system_inflammati	0.93647612
75	MP0002735_abnormal_chemical_nociception	0.91143720
76	MP0000689_abnormal_spleen_morphology	0.90525787
77	MP0005410_abnormal_fertilization	0.90405097
78	MP0001845_abnormal_inflammatory_respons	0.89789366
79	MP0001970_abnormal_pain_threshold	0.89739795
80	MP0000465_gastrointestinal_hemorrhage	0.89409511
81	MP0001486_abnormal_startle_reflex	0.86574105
82	MP0002163_abnormal_gland_morphology	0.85662104
83	MP0000230_abnormal_systemic_arterial	0.85368033
84	MP0002733_abnormal_thermal_nociception	0.85212433
85	MP0003567_abnormal_fetal_cardiomyocyte	0.82925232
86	MP0005332_abnormal_amino_acid	0.82190364
87	MP0008469_abnormal_protein_level	0.81922585
88	MP0001501_abnormal_sleep_pattern	0.81560977
89	MP0000631_abnormal_neuroendocrine_gland	0.81422975
90	MP0001963_abnormal_hearing_physiology	0.79942913
91	MP0006082_CNS_inflammation	0.79642592
92	MP0009643_abnormal_urine_homeostasis	0.79460158
93	MP0006036_abnormal_mitochondrial_physio	0.77982007
94	MP0009745_abnormal_behavioral_response	0.76351845
95	MP0001663_abnormal_digestive_system	0.75573776
96	MP0005085_abnormal_gallbladder_physiolo	0.75291313
97	MP0002419_abnormal_innate_immunity	0.75157771
98	MP0002429_abnormal_blood_cell	0.74550507
99	MP0002722_abnormal_immune_system	0.72549376
100	MP0002693_abnormal_pancreas_physiology	0.72453419

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.67826916
2	Congenital stationary night blindness (HP:0007642)	4.31163720
3	Abnormal rod and cone electroretinograms (HP:0008323)	3.80898060
4	Mitochondrial inheritance (HP:0001427)	3.49834702
5	Reticulocytopenia (HP:0001896)	3.48329248
6	Abolished electroretinogram (ERG) (HP:0000550)	3.36263215
7	Acute necrotizing encephalopathy (HP:0006965)	3.29822015
8	Increased hepatocellular lipid droplets (HP:0006565)	3.25208920
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.09867132
10	Increased CSF lactate (HP:0002490)	3.07546565
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07525720
12	Renal Fanconi syndrome (HP:0001994)	3.07133153
13	Hepatocellular necrosis (HP:0001404)	3.03586926
14	Decreased central vision (HP:0007663)	2.99881235
15	Lipid accumulation in hepatocytes (HP:0006561)	2.96265671
16	Pancreatic cysts (HP:0001737)	2.94090717
17	Constricted visual fields (HP:0001133)	2.91426113
18	Attenuation of retinal blood vessels (HP:0007843)	2.90220175
19	Hepatic necrosis (HP:0002605)	2.89133410
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88138862
21	Acute encephalopathy (HP:0006846)	2.84333257
22	IgG deficiency (HP:0004315)	2.82410760
23	Stenosis of the external auditory canal (HP:0000402)	2.81937976
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.79869498
25	Progressive macrocephaly (HP:0004481)	2.76996069
26	Abnormality of B cell number (HP:0010975)	2.75142321
27	Generalized aminoaciduria (HP:0002909)	2.73786130
28	Increased intramyocellular lipid droplets (HP:0012240)	2.73016595
29	Pancreatic fibrosis (HP:0100732)	2.71847130
30	Abnormality of midbrain morphology (HP:0002418)	2.69574693
31	Molar tooth sign on MRI (HP:0002419)	2.69574693
32	True hermaphroditism (HP:0010459)	2.61665030
33	Type 2 muscle fiber atrophy (HP:0003554)	2.59889443
34	Abnormal number of erythroid precursors (HP:0012131)	2.59657324
35	Macrocytic anemia (HP:0001972)	2.59453849
36	Glycosuria (HP:0003076)	2.54427516
37	Abnormality of urine glucose concentration (HP:0011016)	2.54427516
38	Cerebral edema (HP:0002181)	2.50399664
39	Optic disc pallor (HP:0000543)	2.48863592
40	Abnormality of the prostate (HP:0008775)	2.48231057
41	Pendular nystagmus (HP:0012043)	2.44907014
42	3-Methylglutaconic aciduria (HP:0003535)	2.41594552
43	Renal cortical cysts (HP:0000803)	2.39894797
44	Abnormality of the renal cortex (HP:0011035)	2.39540532
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.37956502
46	Absent/shortened dynein arms (HP:0200106)	2.37956502
47	Dyschromatopsia (HP:0007641)	2.34525338
48	Exertional dyspnea (HP:0002875)	2.32805858
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.30686818
50	Nephronophthisis (HP:0000090)	2.30094817
51	Hypoproteinemia (HP:0003075)	2.29587566
52	Aplastic anemia (HP:0001915)	2.26788820
53	Severe combined immunodeficiency (HP:0004430)	2.25544309
54	Methylmalonic acidemia (HP:0002912)	2.23770744
55	B lymphocytopenia (HP:0010976)	2.22039190
56	Increased muscle lipid content (HP:0009058)	2.20142121
57	Pallor (HP:0000980)	2.19078669
58	Congenital, generalized hypertrichosis (HP:0004540)	2.17886808
59	Stomatitis (HP:0010280)	2.16394152
60	Abnormality of macular pigmentation (HP:0008002)	2.14549970
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13469581
62	Thyroiditis (HP:0100646)	2.13025423
63	Muscle fiber atrophy (HP:0100295)	2.12302720
64	Reduced antithrombin III activity (HP:0001976)	2.11713313
65	Asplenia (HP:0001746)	2.10387402
66	Abnormal drinking behavior (HP:0030082)	2.10042785
67	Polydipsia (HP:0001959)	2.10042785
68	Increased serum lactate (HP:0002151)	2.08428516
69	Panhypogammaglobulinemia (HP:0003139)	2.05366718
70	Absent thumb (HP:0009777)	2.05299520
71	Autoimmune hemolytic anemia (HP:0001890)	2.04746700
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02063069
73	Abnormality of alanine metabolism (HP:0010916)	2.02063069
74	Hyperalaninemia (HP:0003348)	2.02063069
75	Increased IgM level (HP:0003496)	2.01623345
76	Medial flaring of the eyebrow (HP:0010747)	2.01332078
77	Abnormality of the renal collecting system (HP:0004742)	2.01265965
78	Lactic acidosis (HP:0003128)	2.00497233
79	Abnormality of the renal medulla (HP:0100957)	1.97694698
80	Keratoconus (HP:0000563)	1.97039834
81	Increased corneal curvature (HP:0100692)	1.97039834
82	Lethargy (HP:0001254)	1.96992221
83	Abnormality of T cell number (HP:0011839)	1.96718778
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95536551
85	Abnormality of T cells (HP:0002843)	1.94950151
86	Abnormality of renal resorption (HP:0011038)	1.94360196
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.93797684
88	Agammaglobulinemia (HP:0004432)	1.92834584
89	Methylmalonic aciduria (HP:0012120)	1.91339421
90	Hyperglycinemia (HP:0002154)	1.91121757
91	Hyperphosphaturia (HP:0003109)	1.90706479
92	Abnormal ciliary motility (HP:0012262)	1.84914243
93	T lymphocytopenia (HP:0005403)	1.82842153
94	Type II lissencephaly (HP:0007260)	1.82433955
95	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.82113741
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.81722625
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.81722625
98	Polyuria (HP:0000103)	1.78249724
99	Type I transferrin isoform profile (HP:0003642)	1.77058440
100	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.76896714

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.07517344
2	BCKDK	3.79037813
3	TXK	3.64610408
4	ADRBK2	2.67228566
5	TAOK3	2.62156102
6	GRK1	2.61167830
7	MAP4K2	2.49319967
8	TLK1	2.40868557
9	FRK	2.35965517
10	KDR	2.20714552
11	KIT	2.17473521
12	ZAK	2.14543755
13	NUAK1	2.05763391
14	EIF2AK3	1.87211409
15	SCYL2	1.86236573
16	MAP4K1	1.79404614
17	VRK2	1.70053446
18	PINK1	1.65324555
19	FLT3	1.53536438
20	TEC	1.51655455
21	SYK	1.50177962
22	BMPR2	1.42485349
23	WNK4	1.42037994
24	ITK	1.34249595
25	STK16	1.33331172
26	TIE1	1.32655830
27	MAP3K12	1.32612788
28	VRK1	1.22681836
29	OXSR1	1.22661640
30	INSRR	1.16069464
31	PASK	1.10934614
32	WNK3	1.10170267
33	TNK2	1.09339820
34	GRK6	1.08908786
35	BTK	1.08811191
36	CSF1R	1.08722686
37	BMPR1B	1.05106108
38	FES	1.04534321
39	IKBKE	1.04270520
40	IKBKB	1.00573662
41	DAPK2	0.99609567
42	CAMKK2	0.96127414
43	TESK2	0.92902810
44	MAP2K6	0.87973535
45	DAPK1	0.87029497
46	LYN	0.84750506
47	DYRK2	0.84241946
48	STK39	0.83501028
49	MUSK	0.81700596
50	PRKCQ	0.81608029
51	LCK	0.77735354
52	DAPK3	0.75744092
53	MYLK	0.74939297
54	OBSCN	0.74294581
55	MATK	0.74134502
56	JAK3	0.72009611
57	ADRBK1	0.71982634
58	TRPM7	0.71904586
59	GRK7	0.68885712
60	RPS6KA5	0.68271448
61	PRKG2	0.64001427
62	CSNK1G1	0.61771596
63	MAPK13	0.61520951
64	MAPKAPK5	0.57525435
65	EIF2AK2	0.57196178
66	PLK4	0.57053885
67	PIK3CG	0.55392763
68	RPS6KA4	0.55285859
69	CAMKK1	0.54302321
70	CSNK1G3	0.53743594
71	PRKCE	0.52723280
72	IGF1R	0.50985258
73	ACVR1B	0.50461586
74	PRKCD	0.49743005
75	PRKACA	0.48832029
76	PIK3CA	0.48122322
77	PIM1	0.47928732
78	ZAP70	0.47756219
79	MST4	0.47584121
80	CDK3	0.46767194
81	PRKCA	0.46629388
82	GRK5	0.46524050
83	CAMK1	0.46401052
84	RPS6KA6	0.44158322
85	AURKA	0.43634911
86	CSNK1G2	0.43394326
87	MAP3K4	0.42262088
88	ERBB3	0.41961265
89	MAP3K11	0.41958778
90	MAP2K7	0.40955878
91	RPS6KB2	0.40272819
92	CSNK2A2	0.40022644
93	CSNK2A1	0.37238445
94	HCK	0.36651990
95	ABL1	0.36455334
96	PRKCH	0.35792002
97	CSNK1A1	0.35316195
98	ILK	0.34118868
99	MKNK1	0.33195582
100	PHKG2	0.32887632

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.94060196
2	Asthma_Homo sapiens_hsa05310	3.93273496
3	Allograft rejection_Homo sapiens_hsa05330	3.32034605
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.12773538
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.04569152
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.00103576
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.94208714
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.71884765
9	Proteasome_Homo sapiens_hsa03050	2.58409050
10	Parkinsons disease_Homo sapiens_hsa05012	2.39612347
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.38896408
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.09587262
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86021549
14	Phototransduction_Homo sapiens_hsa04744	1.77930751
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76972951
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72877534
17	Alzheimers disease_Homo sapiens_hsa05010	1.56941153
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56125790
19	Protein export_Homo sapiens_hsa03060	1.54244846
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51235847
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.47436021
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45748159
23	Huntingtons disease_Homo sapiens_hsa05016	1.41279248
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.36929760
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34921177
26	RNA polymerase_Homo sapiens_hsa03020	1.34740715
27	Homologous recombination_Homo sapiens_hsa03440	1.29355408
28	Propanoate metabolism_Homo sapiens_hsa00640	1.22829140
29	RNA degradation_Homo sapiens_hsa03018	1.17850511
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.14804418
31	One carbon pool by folate_Homo sapiens_hsa00670	1.10399566
32	Caffeine metabolism_Homo sapiens_hsa00232	1.09994344
33	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.09257255
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08676347
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08254493
36	Viral myocarditis_Homo sapiens_hsa05416	1.07206673
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04826121
38	Olfactory transduction_Homo sapiens_hsa04740	1.04611684
39	Retinol metabolism_Homo sapiens_hsa00830	1.04389959
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03234027
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01006807
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00910869
43	Nitrogen metabolism_Homo sapiens_hsa00910	1.00170751
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97873931
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96231448
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95372675
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.90167659
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.89702640
49	Peroxisome_Homo sapiens_hsa04146	0.89071214
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87864942
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86869742
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86044157
53	Butanoate metabolism_Homo sapiens_hsa00650	0.85687854
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.85177372
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.84877599
56	Leishmaniasis_Homo sapiens_hsa05140	0.84279563
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78201403
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77423051
59	Taste transduction_Homo sapiens_hsa04742	0.74336285
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73406279
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71454252
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70774609
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70290904
64	Salivary secretion_Homo sapiens_hsa04970	0.68647871
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.66056333
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64584092
67	Nicotine addiction_Homo sapiens_hsa05033	0.64438737
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62487672
69	Purine metabolism_Homo sapiens_hsa00230	0.61785555
70	Regulation of autophagy_Homo sapiens_hsa04140	0.60839774
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.59735143
72	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.55487435
73	Basal transcription factors_Homo sapiens_hsa03022	0.53286395
74	African trypanosomiasis_Homo sapiens_hsa05143	0.51671953
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.50497842
76	Metabolic pathways_Homo sapiens_hsa01100	0.47721448
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.46287965
78	Base excision repair_Homo sapiens_hsa03410	0.45259377
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40895322
80	RNA transport_Homo sapiens_hsa03013	0.40428521
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40332025
82	Morphine addiction_Homo sapiens_hsa05032	0.40146169
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39213460
84	Mismatch repair_Homo sapiens_hsa03430	0.36299225
85	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36031787
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34749008
87	Serotonergic synapse_Homo sapiens_hsa04726	0.33728313
88	Herpes simplex infection_Homo sapiens_hsa05168	0.33176991
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.32426692
90	Malaria_Homo sapiens_hsa05144	0.32311061
91	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31379547
92	Spliceosome_Homo sapiens_hsa03040	0.29301571
93	Sulfur metabolism_Homo sapiens_hsa00920	0.29169391
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27124545
95	Circadian entrainment_Homo sapiens_hsa04713	0.25768151
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.23346631
97	Glutathione metabolism_Homo sapiens_hsa00480	0.21562381
98	Sulfur relay system_Homo sapiens_hsa04122	0.21134550
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.20611594
100	Tuberculosis_Homo sapiens_hsa05152	0.20461416

RPS3AP25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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