ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.73262080
2	ribosomal small subunit assembly (GO:0000028)	5.59601025
3	cytidine deamination (GO:0009972)	4.32344324
4	cytidine metabolic process (GO:0046087)	4.32344324
5	cytidine catabolic process (GO:0006216)	4.32344324
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.16224343
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.08158781
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.08158781
9	viral transcription (GO:0019083)	3.67680169
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.66333807
11	translational termination (GO:0006415)	3.59786098
12	ribosomal large subunit biogenesis (GO:0042273)	3.52956414
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.51341283
14	ATP synthesis coupled proton transport (GO:0015986)	3.51341283
15	protein neddylation (GO:0045116)	3.42499318
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.41883187
17	translational elongation (GO:0006414)	3.35044487
18	regulation of memory T cell differentiation (GO:0043380)	3.29746333
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.28666006
20	iron-sulfur cluster assembly (GO:0016226)	3.22155710
21	metallo-sulfur cluster assembly (GO:0031163)	3.22155710
22	protein complex biogenesis (GO:0070271)	3.22022911
23	cotranslational protein targeting to membrane (GO:0006613)	3.21215074
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20671397
25	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.18092051
26	protein targeting to ER (GO:0045047)	3.17484407
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16752995
28	NADH dehydrogenase complex assembly (GO:0010257)	3.16752995
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16752995
30	negative regulation of mast cell activation (GO:0033004)	3.14890235
31	piRNA metabolic process (GO:0034587)	3.10028896
32	protein localization to endoplasmic reticulum (GO:0070972)	3.03567613
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.02335191
34	kynurenine metabolic process (GO:0070189)	3.01903814
35	tryptophan catabolic process (GO:0006569)	3.01658995
36	indole-containing compound catabolic process (GO:0042436)	3.01658995
37	indolalkylamine catabolic process (GO:0046218)	3.01658995
38	positive regulation of defense response to virus by host (GO:0002230)	2.99721510
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99150982
40	pseudouridine synthesis (GO:0001522)	2.98929965
41	behavioral response to nicotine (GO:0035095)	2.98553529
42	regulation of regulatory T cell differentiation (GO:0045589)	2.96357808
43	mitochondrial respiratory chain complex assembly (GO:0033108)	2.90159358
44	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.89010954
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.86578837
46	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.81674341
47	termination of RNA polymerase III transcription (GO:0006386)	2.81591401
48	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81591401
49	DNA demethylation (GO:0080111)	2.81530034
50	maturation of SSU-rRNA (GO:0030490)	2.78023916
51	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.77341061
52	platelet dense granule organization (GO:0060155)	2.75231777
53	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.70499245
54	seminiferous tubule development (GO:0072520)	2.70345859
55	purine nucleotide salvage (GO:0032261)	2.70183439
56	indolalkylamine metabolic process (GO:0006586)	2.69253125
57	proteasome assembly (GO:0043248)	2.68207877
58	translational initiation (GO:0006413)	2.68006441
59	electron transport chain (GO:0022900)	2.67968140
60	DNA dealkylation (GO:0035510)	2.66226536
61	respiratory electron transport chain (GO:0022904)	2.65155826
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63981986
63	translation (GO:0006412)	2.62580186
64	purine-containing compound salvage (GO:0043101)	2.61914014
65	base-excision repair, AP site formation (GO:0006285)	2.61293015
66	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.60735908
67	GPI anchor metabolic process (GO:0006505)	2.60365157
68	positive regulation of B cell differentiation (GO:0045579)	2.59850794
69	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.59106891
70	ribosomal small subunit biogenesis (GO:0042274)	2.58543065
71	response to pheromone (GO:0019236)	2.56397424
72	fucose catabolic process (GO:0019317)	2.56255715
73	L-fucose metabolic process (GO:0042354)	2.56255715
74	L-fucose catabolic process (GO:0042355)	2.56255715
75	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.54976608
76	viral life cycle (GO:0019058)	2.54691265
77	cellular protein complex disassembly (GO:0043624)	2.53835699
78	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.53787870
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.53132304
80	mannosylation (GO:0097502)	2.51392614
81	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.51083718
82	detection of light stimulus involved in sensory perception (GO:0050962)	2.50933326
83	detection of light stimulus involved in visual perception (GO:0050908)	2.50933326
84	positive regulation of interleukin-17 production (GO:0032740)	2.47297982
85	tRNA processing (GO:0008033)	2.45703788
86	GTP biosynthetic process (GO:0006183)	2.45589458
87	axoneme assembly (GO:0035082)	2.45464808
88	male meiosis I (GO:0007141)	2.45267382
89	aggressive behavior (GO:0002118)	2.44469789
90	regulation of action potential (GO:0098900)	2.43798767
91	tryptophan metabolic process (GO:0006568)	2.43521687
92	estrogen biosynthetic process (GO:0006703)	2.43435828
93	rRNA processing (GO:0006364)	2.42787106
94	GPI anchor biosynthetic process (GO:0006506)	2.42075083
95	rRNA metabolic process (GO:0016072)	2.41645750
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.41160410
97	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.40670756
98	adenosine metabolic process (GO:0046085)	2.40156753
99	S-adenosylmethionine metabolic process (GO:0046500)	2.40031595
100	DNA methylation involved in gamete generation (GO:0043046)	2.39830562

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.56495371
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.44638944
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.36969553
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.92061439
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89788637
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.82335662
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.80260148
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.79323665
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62267912
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59255828
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.51320519
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47917970
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22898775
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.21591814
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.09404286
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06254970
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99128222
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90970596
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89921238
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.87632821
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86106111
22	EWS_26573619_Chip-Seq_HEK293_Human	1.80285694
23	FUS_26573619_Chip-Seq_HEK293_Human	1.79685061
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.78522073
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77140938
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.76699513
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74946041
28	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.74115373
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.71931998
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69542339
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65722229
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.63258986
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62941547
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.58241894
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.57662649
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.57662649
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56765688
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55621961
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48551146
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.45448264
41	AR_20517297_ChIP-Seq_VCAP_Human	1.44230445
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.43965505
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42058429
44	NCOR_22424771_ChIP-Seq_293T_Human	1.40740893
45	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.40505839
46	MYB_26560356_Chip-Seq_TH2_Human	1.39437590
47	P300_19829295_ChIP-Seq_ESCs_Human	1.37006988
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36774573
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35495404
50	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34792708
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34660149
52	GATA3_26560356_Chip-Seq_TH2_Human	1.33402627
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33161814
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32308051
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32149359
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30613172
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.26732899
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26732899
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26476793
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26476793
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23074095
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22279786
63	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.22045967
64	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19400671
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18869038
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18643043
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18522716
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17113378
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.16734942
70	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16215033
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14315914
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14199287
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13369736
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12462745
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12313251
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11931455
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11608002
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11022780
79	GBX2_23144817_ChIP-Seq_PC3_Human	1.09971389
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09698741
81	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.08603815
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06170435
83	ERG_20517297_ChIP-Seq_VCAP_Human	1.03914329
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03680972
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02600539
86	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01034230
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00425597
88	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97937365
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97847324
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97036753
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.96463433
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96165986
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93995683
94	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93927782
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93211709
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.92984420
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92932201
98	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92769633
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92488615
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91825788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.50409002
2	MP0006292_abnormal_olfactory_placode	2.67054687
3	MP0001835_abnormal_antigen_presentation	2.57519604
4	MP0009379_abnormal_foot_pigmentation	2.53953259
5	MP0002102_abnormal_ear_morphology	2.47673224
6	MP0008877_abnormal_DNA_methylation	2.25284854
7	MP0002837_dystrophic_cardiac_calcinosis	2.24750409
8	MP0005646_abnormal_pituitary_gland	2.24103394
9	MP0004147_increased_porphyrin_level	2.15697728
10	MP0005075_abnormal_melanosome_morpholog	2.00647845
11	MP0005645_abnormal_hypothalamus_physiol	1.99612120
12	MP0006072_abnormal_retinal_apoptosis	1.98757271
13	MP0001873_stomach_inflammation	1.96800832
14	MP0003806_abnormal_nucleotide_metabolis	1.96619942
15	MP0008872_abnormal_physiological_respon	1.93723893
16	MP0003646_muscle_fatigue	1.83931528
17	MP0002736_abnormal_nociception_after	1.83871329
18	MP0001968_abnormal_touch/_nociception	1.83753689
19	MP0008995_early_reproductive_senescence	1.82453403
20	MP0005551_abnormal_eye_electrophysiolog	1.80920056
21	MP0009785_altered_susceptibility_to	1.75190116
22	MP0002148_abnormal_hypersensitivity_rea	1.67413791
23	MP0009333_abnormal_splenocyte_physiolog	1.60165316
24	MP0001800_abnormal_humoral_immune	1.59903190
25	MP0002160_abnormal_reproductive_system	1.58976657
26	MP0001986_abnormal_taste_sensitivity	1.58679727
27	MP0004145_abnormal_muscle_electrophysio	1.57039483
28	MP0003252_abnormal_bile_duct	1.56056130
29	MP0008058_abnormal_DNA_repair	1.54385695
30	MP0003011_delayed_dark_adaptation	1.51430574
31	MP0004885_abnormal_endolymph	1.51321860
32	MP0005084_abnormal_gallbladder_morpholo	1.51139001
33	MP0002166_altered_tumor_susceptibility	1.49240407
34	MP0008875_abnormal_xenobiotic_pharmacok	1.48802741
35	MP0002138_abnormal_hepatobiliary_system	1.48577207
36	MP0001764_abnormal_homeostasis	1.48373401
37	MP0002876_abnormal_thyroid_physiology	1.46412831
38	MP0003763_abnormal_thymus_physiology	1.46065329
39	MP0005389_reproductive_system_phenotype	1.45381206
40	MP0000372_irregular_coat_pigmentation	1.44045102
41	MP0003195_calcinosis	1.40829727
42	MP0005000_abnormal_immune_tolerance	1.40728905
43	MP0002006_tumorigenesis	1.40242170
44	MP0003786_premature_aging	1.36833595
45	MP0005253_abnormal_eye_physiology	1.31318862
46	MP0001790_abnormal_immune_system	1.29612548
47	MP0005387_immune_system_phenotype	1.29612548
48	MP0003787_abnormal_imprinting	1.29201829
49	MP0000685_abnormal_immune_system	1.27550114
50	MP0002163_abnormal_gland_morphology	1.26917603
51	MP0002723_abnormal_immune_serum	1.25698581
52	MP0002420_abnormal_adaptive_immunity	1.22407943
53	MP0002234_abnormal_pharynx_morphology	1.19479446
54	MP0001819_abnormal_immune_cell	1.19302410
55	MP0005410_abnormal_fertilization	1.18820794
56	MP0004142_abnormal_muscle_tone	1.17773182
57	MP0006036_abnormal_mitochondrial_physio	1.15789121
58	MP0002452_abnormal_antigen_presenting	1.11067927
59	MP0006276_abnormal_autonomic_nervous	1.09077979
60	MP0001905_abnormal_dopamine_level	1.06578553
61	MP0002095_abnormal_skin_pigmentation	1.05152309
62	MP0005025_abnormal_response_to	1.03441843
63	MP0001919_abnormal_reproductive_system	1.01647212
64	MP0008789_abnormal_olfactory_epithelium	1.01150162
65	MP0000678_abnormal_parathyroid_gland	1.00517443
66	MP0000689_abnormal_spleen_morphology	0.99956478
67	MP0005636_abnormal_mineral_homeostasis	0.99904793
68	MP0002693_abnormal_pancreas_physiology	0.99732055
69	MP0002398_abnormal_bone_marrow	0.98465043
70	MP0003866_abnormal_defecation	0.95514426
71	MP0000716_abnormal_immune_system	0.94352888
72	MP0005360_urolithiasis	0.92699400
73	MP0003186_abnormal_redox_activity	0.92440060
74	MP0002272_abnormal_nervous_system	0.90919894
75	MP0003567_abnormal_fetal_cardiomyocyte	0.89805569
76	MP0000631_abnormal_neuroendocrine_gland	0.88973241
77	MP0001485_abnormal_pinna_reflex	0.87626751
78	MP0001501_abnormal_sleep_pattern	0.86971492
79	MP0003878_abnormal_ear_physiology	0.86947729
80	MP0005377_hearing/vestibular/ear_phenot	0.86947729
81	MP0009745_abnormal_behavioral_response	0.84472373
82	MP0005670_abnormal_white_adipose	0.83375685
83	MP0002405_respiratory_system_inflammati	0.81831890
84	MP0003718_maternal_effect	0.80932567
85	MP0003880_abnormal_central_pattern	0.80024187
86	MP0006082_CNS_inflammation	0.78783740
87	MP0005174_abnormal_tail_pigmentation	0.78300089
88	MP0002722_abnormal_immune_system	0.76990224
89	MP0005379_endocrine/exocrine_gland_phen	0.76848629
90	MP0005332_abnormal_amino_acid	0.74976615
91	MP0005085_abnormal_gallbladder_physiolo	0.74780541
92	MP0001963_abnormal_hearing_physiology	0.74612432
93	MP0001765_abnormal_ion_homeostasis	0.74464577
94	MP0001845_abnormal_inflammatory_respons	0.73910964
95	MP0002277_abnormal_respiratory_mucosa	0.73577302
96	MP0002653_abnormal_ependyma_morphology	0.73137087
97	MP0001119_abnormal_female_reproductive	0.72934380
98	MP0002822_catalepsy	0.72857064
99	MP0000681_abnormal_thyroid_gland	0.71940312
100	MP0001486_abnormal_startle_reflex	0.71928903

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.08012328
2	Congenital stationary night blindness (HP:0007642)	3.81134356
3	Abnormal rod and cone electroretinograms (HP:0008323)	3.50325321
4	Mitochondrial inheritance (HP:0001427)	3.42679536
5	Acute necrotizing encephalopathy (HP:0006965)	3.35418025
6	Pancreatic cysts (HP:0001737)	3.07348812
7	Severe combined immunodeficiency (HP:0004430)	3.06807138
8	Increased CSF lactate (HP:0002490)	3.06153143
9	IgG deficiency (HP:0004315)	3.03269702
10	3-Methylglutaconic aciduria (HP:0003535)	3.03027291
11	Acute encephalopathy (HP:0006846)	3.00919491
12	Abolished electroretinogram (ERG) (HP:0000550)	3.00585956
13	Abnormality of the prostate (HP:0008775)	2.99966787
14	Elevated erythrocyte sedimentation rate (HP:0003565)	2.94347257
15	Hypoproteinemia (HP:0003075)	2.91871096
16	Abnormality of B cell number (HP:0010975)	2.90395037
17	Renal Fanconi syndrome (HP:0001994)	2.89804461
18	Increased hepatocellular lipid droplets (HP:0006565)	2.89220142
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89112856
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.88858575
21	Hepatocellular necrosis (HP:0001404)	2.84211325
22	Molar tooth sign on MRI (HP:0002419)	2.81609982
23	Abnormality of midbrain morphology (HP:0002418)	2.81609982
24	Aplastic anemia (HP:0001915)	2.81008985
25	Constricted visual fields (HP:0001133)	2.80950372
26	Attenuation of retinal blood vessels (HP:0007843)	2.80711106
27	Progressive macrocephaly (HP:0004481)	2.79141395
28	Lipid accumulation in hepatocytes (HP:0006561)	2.77401388
29	Pancreatic fibrosis (HP:0100732)	2.77276106
30	True hermaphroditism (HP:0010459)	2.73559366
31	Hepatic necrosis (HP:0002605)	2.71942544
32	Reticulocytopenia (HP:0001896)	2.70185126
33	Thyroiditis (HP:0100646)	2.67356263
34	Decreased central vision (HP:0007663)	2.67110600
35	Stenosis of the external auditory canal (HP:0000402)	2.65068973
36	B lymphocytopenia (HP:0010976)	2.63108074
37	Pendular nystagmus (HP:0012043)	2.56535912
38	Cerebral edema (HP:0002181)	2.48959718
39	Optic disc pallor (HP:0000543)	2.47307998
40	Stomatitis (HP:0010280)	2.46328622
41	Renal cortical cysts (HP:0000803)	2.43868012
42	Increased intramyocellular lipid droplets (HP:0012240)	2.42406295
43	Panhypogammaglobulinemia (HP:0003139)	2.41746949
44	Methylmalonic acidemia (HP:0002912)	2.40549197
45	Prostate neoplasm (HP:0100787)	2.39246961
46	Medial flaring of the eyebrow (HP:0010747)	2.38815600
47	Autoimmune hemolytic anemia (HP:0001890)	2.36012446
48	Nephronophthisis (HP:0000090)	2.33096605
49	Abnormality of T cell number (HP:0011839)	2.31575861
50	Combined immunodeficiency (HP:0005387)	2.30338243
51	Abnormality of the renal collecting system (HP:0004742)	2.28354372
52	T lymphocytopenia (HP:0005403)	2.26543985
53	Abnormality of the renal cortex (HP:0011035)	2.24647165
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24387877
55	Abnormality of alanine metabolism (HP:0010916)	2.24387877
56	Hyperalaninemia (HP:0003348)	2.24387877
57	Abnormality of cells of the erythroid lineage (HP:0012130)	2.21424497
58	Hyperglycinemia (HP:0002154)	2.19766046
59	Increased serum lactate (HP:0002151)	2.19309482
60	Type 2 muscle fiber atrophy (HP:0003554)	2.18915136
61	Abnormality of T cells (HP:0002843)	2.15959781
62	Generalized aminoaciduria (HP:0002909)	2.15552662
63	Genetic anticipation (HP:0003743)	2.15524178
64	Abnormality of urine glucose concentration (HP:0011016)	2.15343839
65	Glycosuria (HP:0003076)	2.15343839
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10235891
67	Absent/shortened dynein arms (HP:0200106)	2.10235891
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.09643979
69	Lactic acidosis (HP:0003128)	2.09617317
70	Asplenia (HP:0001746)	2.04101332
71	Increased muscle lipid content (HP:0009058)	2.02808119
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02059302
73	Increased IgM level (HP:0003496)	2.01829325
74	Macrocytic anemia (HP:0001972)	2.01086614
75	Lethargy (HP:0001254)	1.98413994
76	Exertional dyspnea (HP:0002875)	1.97451388
77	Keratoconus (HP:0000563)	1.97331675
78	Increased corneal curvature (HP:0100692)	1.97331675
79	Abnormality of eosinophils (HP:0001879)	1.97015354
80	Abnormality of macular pigmentation (HP:0008002)	1.96650107
81	Severe visual impairment (HP:0001141)	1.96430572
82	Abnormality of DNA repair (HP:0003254)	1.96328315
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96281580
84	Absent thumb (HP:0009777)	1.94619361
85	Abnormal drinking behavior (HP:0030082)	1.88843354
86	Polydipsia (HP:0001959)	1.88843354
87	Abnormal number of erythroid precursors (HP:0012131)	1.88666913
88	Abnormality of the renal medulla (HP:0100957)	1.85357941
89	Pancytopenia (HP:0001876)	1.83091678
90	Methylmalonic aciduria (HP:0012120)	1.82291679
91	Abnormality of male internal genitalia (HP:0000022)	1.80811585
92	Ketosis (HP:0001946)	1.77691639
93	Type I transferrin isoform profile (HP:0003642)	1.75788329
94	Hyperglycinuria (HP:0003108)	1.74563515
95	Abnormality of renal resorption (HP:0011038)	1.74087304
96	Agammaglobulinemia (HP:0004432)	1.73727008
97	Abnormality of T cell physiology (HP:0011840)	1.73367183
98	Abnormality of serum amino acid levels (HP:0003112)	1.72768496
99	Reduced antithrombin III activity (HP:0001976)	1.70551967
100	Dyschromatopsia (HP:0007641)	1.70524417

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.31648561
2	TXK	3.90993721
3	BCKDK	3.70798119
4	FRK	2.90005950
5	GRK1	2.84917185
6	TAOK3	2.66174157
7	VRK2	2.41170814
8	ZAK	2.40780655
9	NUAK1	2.36928695
10	ADRBK2	2.34983607
11	KDR	2.14220453
12	EIF2AK3	2.09572503
13	MAP4K2	2.00819420
14	PINK1	1.93934688
15	OXSR1	1.89935770
16	TLK1	1.73584171
17	BMPR1B	1.69966801
18	TEC	1.67646690
19	PASK	1.65069742
20	KIT	1.60066674
21	VRK1	1.58079206
22	TESK2	1.53942324
23	ITK	1.52140311
24	TIE1	1.29280389
25	FLT3	1.26975208
26	MST4	1.24675148
27	MAP4K1	1.23978404
28	SCYL2	1.21126583
29	SYK	1.19563828
30	TNK2	1.16144304
31	MAP3K12	1.15337128
32	WNK3	1.12468813
33	WNK4	1.10417377
34	MUSK	1.05501715
35	INSRR	1.04555960
36	STK16	0.98668920
37	DAPK1	0.93416453
38	IKBKB	0.91881376
39	BTK	0.91325599
40	ACVR1B	0.91001077
41	GRK6	0.89573117
42	PRKCQ	0.87964365
43	BMPR2	0.87233299
44	FES	0.82186574
45	CSF1R	0.80957154
46	STK39	0.75236273
47	PIK3CG	0.74368770
48	DYRK2	0.74347810
49	MAP2K6	0.73006168
50	RPS6KB2	0.71068774
51	TRPM7	0.70888819
52	ADRBK1	0.70551814
53	LCK	0.66724316
54	LYN	0.64552866
55	CAMKK2	0.64509074
56	MKNK1	0.63719922
57	DAPK2	0.63705383
58	OBSCN	0.62987433
59	BRSK2	0.61359400
60	MAPK13	0.59331171
61	MKNK2	0.57820199
62	PBK	0.57367294
63	MATK	0.53467162
64	MYLK	0.53283028
65	EIF2AK2	0.52915588
66	MAPKAPK3	0.50440804
67	IGF1R	0.49159633
68	ERBB3	0.49088888
69	TGFBR1	0.49004965
70	CSNK1G1	0.48611100
71	PRKCE	0.48108586
72	DAPK3	0.47977865
73	MAPKAPK5	0.46173552
74	PIM1	0.44612536
75	GRK7	0.43769440
76	IKBKE	0.43680845
77	PLK4	0.42593614
78	MAP2K7	0.42284283
79	TRIM28	0.42181545
80	CDK3	0.42021309
81	PRKACA	0.41705631
82	PRKCA	0.41493216
83	RPS6KA5	0.41398655
84	NLK	0.40857198
85	JAK3	0.40678603
86	PIK3CA	0.40591132
87	TAF1	0.40455033
88	PRKCG	0.40296028
89	EIF2AK1	0.38088146
90	CSNK1G3	0.37951254
91	CSNK2A1	0.37833075
92	CSNK2A2	0.37432828
93	PLK3	0.37205162
94	MAP3K4	0.36869252
95	CSNK1A1	0.35517398
96	MAP3K11	0.34875074
97	NME1	0.34384992
98	RPS6KA4	0.33797625
99	PRKCD	0.33097841
100	CAMKK1	0.31454393

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.44574276
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.16354230
3	Proteasome_Homo sapiens_hsa03050	2.92787877
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.83276910
5	Asthma_Homo sapiens_hsa05310	2.70051650
6	Allograft rejection_Homo sapiens_hsa05330	2.60553871
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.44211589
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.34687205
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31117970
10	Parkinsons disease_Homo sapiens_hsa05012	2.23402233
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18856557
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08108772
13	RNA polymerase_Homo sapiens_hsa03020	2.07793129
14	Protein export_Homo sapiens_hsa03060	1.98030916
15	Phototransduction_Homo sapiens_hsa04744	1.91122489
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73310391
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.69438443
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.65724378
19	Homologous recombination_Homo sapiens_hsa03440	1.62802738
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62115923
21	Propanoate metabolism_Homo sapiens_hsa00640	1.57375029
22	RNA degradation_Homo sapiens_hsa03018	1.52550486
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44670952
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.44666057
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41902629
26	One carbon pool by folate_Homo sapiens_hsa00670	1.37783021
27	Alzheimers disease_Homo sapiens_hsa05010	1.36974338
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.34619650
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34106595
30	Huntingtons disease_Homo sapiens_hsa05016	1.32651408
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30107067
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.28003561
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24735828
34	Butanoate metabolism_Homo sapiens_hsa00650	1.23650808
35	Caffeine metabolism_Homo sapiens_hsa00232	1.23569123
36	Olfactory transduction_Homo sapiens_hsa04740	1.22001319
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.21931822
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.21787506
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21135777
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16507434
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.15049424
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12642546
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.12294838
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12220921
45	Retinol metabolism_Homo sapiens_hsa00830	1.11830212
46	Basal transcription factors_Homo sapiens_hsa03022	1.08304631
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06617405
48	Ether lipid metabolism_Homo sapiens_hsa00565	1.05170773
49	Peroxisome_Homo sapiens_hsa04146	1.03879746
50	Purine metabolism_Homo sapiens_hsa00230	0.99190587
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97479971
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94353541
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94336542
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.92412239
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.90836608
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88225444
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86986939
58	Base excision repair_Homo sapiens_hsa03410	0.86690438
59	Mismatch repair_Homo sapiens_hsa03430	0.85757102
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79159344
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78045773
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77637651
63	Regulation of autophagy_Homo sapiens_hsa04140	0.74684896
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.73832912
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72099929
66	RNA transport_Homo sapiens_hsa03013	0.70947242
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.69437849
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68659888
69	Taste transduction_Homo sapiens_hsa04742	0.68101572
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66463191
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63888742
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.63467669
73	Metabolic pathways_Homo sapiens_hsa01100	0.62842018
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.62702333
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60215690
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60007593
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57291876
78	DNA replication_Homo sapiens_hsa03030	0.56004976
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55092001
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53609380
81	Spliceosome_Homo sapiens_hsa03040	0.53532310
82	Viral myocarditis_Homo sapiens_hsa05416	0.51775364
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51222023
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49284435
85	Nicotine addiction_Homo sapiens_hsa05033	0.46243050
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43587489
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.43058681
88	Salivary secretion_Homo sapiens_hsa04970	0.39955382
89	Sulfur relay system_Homo sapiens_hsa04122	0.39819745
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38720963
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35247484
92	Sulfur metabolism_Homo sapiens_hsa00920	0.35114168
93	Fatty acid elongation_Homo sapiens_hsa00062	0.32799791
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.30593858
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.30307305
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29297845
97	Morphine addiction_Homo sapiens_hsa05032	0.28008800
98	Herpes simplex infection_Homo sapiens_hsa05168	0.27534119
99	Measles_Homo sapiens_hsa05162	0.27213223
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25561117

RPS3AP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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