ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.48788605
2	ribosomal large subunit biogenesis (GO:0042273)	5.47036290
3	viral transcription (GO:0019083)	5.07726083
4	translational termination (GO:0006415)	4.88892016
5	base-excision repair, AP site formation (GO:0006285)	4.66550064
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.50293789
7	cotranslational protein targeting to membrane (GO:0006613)	4.46355821
8	protein targeting to ER (GO:0045047)	4.42272894
9	protein neddylation (GO:0045116)	4.41723099
10	ATP synthesis coupled proton transport (GO:0015986)	4.30432731
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.30432731
12	purine deoxyribonucleotide catabolic process (GO:0009155)	4.28765451
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.28227645
14	translational elongation (GO:0006414)	4.21756157
15	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.18740587
16	protein localization to endoplasmic reticulum (GO:0070972)	4.14008787
17	piRNA metabolic process (GO:0034587)	4.07756474
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.07533245
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.98959015
20	NADH dehydrogenase complex assembly (GO:0010257)	3.98959015
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.98959015
22	DNA deamination (GO:0045006)	3.97146039
23	deoxyribonucleotide catabolic process (GO:0009264)	3.91879616
24	ribosomal small subunit biogenesis (GO:0042274)	3.80092752
25	deoxyribose phosphate catabolic process (GO:0046386)	3.78022056
26	kynurenine metabolic process (GO:0070189)	3.77950222
27	protein complex biogenesis (GO:0070271)	3.76339597
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.72920235
29	termination of RNA polymerase III transcription (GO:0006386)	3.72920235
30	cellular protein complex disassembly (GO:0043624)	3.67201699
31	protein localization to cilium (GO:0061512)	3.62374309
32	viral life cycle (GO:0019058)	3.57840116
33	ubiquinone biosynthetic process (GO:0006744)	3.55208313
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53037208
35	respiratory electron transport chain (GO:0022904)	3.51474211
36	pyrimidine nucleotide catabolic process (GO:0006244)	3.48572565
37	negative regulation of mast cell activation (GO:0033004)	3.48368363
38	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.48320183
39	electron transport chain (GO:0022900)	3.47305367
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42735420
41	aldehyde catabolic process (GO:0046185)	3.35621728
42	behavioral response to nicotine (GO:0035095)	3.31897084
43	translational initiation (GO:0006413)	3.27545795
44	protein deneddylation (GO:0000338)	3.26235776
45	GTP biosynthetic process (GO:0006183)	3.26145444
46	tryptophan catabolic process (GO:0006569)	3.23877575
47	indole-containing compound catabolic process (GO:0042436)	3.23877575
48	indolalkylamine catabolic process (GO:0046218)	3.23877575
49	dopamine transport (GO:0015872)	3.22846693
50	DNA damage response, detection of DNA damage (GO:0042769)	3.22425254
51	seminiferous tubule development (GO:0072520)	3.20546050
52	translation (GO:0006412)	3.15433266
53	ribonucleoprotein complex biogenesis (GO:0022613)	3.12696567
54	cellular component biogenesis (GO:0044085)	3.12460099
55	cullin deneddylation (GO:0010388)	3.11628799
56	indolalkylamine metabolic process (GO:0006586)	3.09432085
57	protein complex disassembly (GO:0043241)	3.09186403
58	maturation of SSU-rRNA (GO:0030490)	3.06607833
59	ubiquinone metabolic process (GO:0006743)	3.03781092
60	chaperone-mediated protein transport (GO:0072321)	2.97134252
61	macromolecular complex disassembly (GO:0032984)	2.95591599
62	axoneme assembly (GO:0035082)	2.94612338
63	male meiosis I (GO:0007141)	2.92515502
64	negative regulation of T cell differentiation in thymus (GO:0033085)	2.90521046
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.90045922
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.89154781
67	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.89154781
68	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85788044
69	hydrogen ion transmembrane transport (GO:1902600)	2.84075953
70	regulation of mitochondrial translation (GO:0070129)	2.79068390
71	proton transport (GO:0015992)	2.77977622
72	quinone biosynthetic process (GO:1901663)	2.77451521
73	protein targeting to membrane (GO:0006612)	2.76343459
74	protein-cofactor linkage (GO:0018065)	2.76078709
75	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.75306072
76	positive regulation of gastrulation (GO:2000543)	2.75124055
77	negative regulation of telomere maintenance (GO:0032205)	2.74979873
78	mannosylation (GO:0097502)	2.73935657
79	platelet dense granule organization (GO:0060155)	2.73858775
80	UTP biosynthetic process (GO:0006228)	2.73024017
81	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.70255782
82	substrate-independent telencephalic tangential migration (GO:0021826)	2.70255782
83	regulation of cilium movement (GO:0003352)	2.70077602
84	hydrogen transport (GO:0006818)	2.69296592
85	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.65472668
86	xenobiotic catabolic process (GO:0042178)	2.64407841
87	cytochrome complex assembly (GO:0017004)	2.63071048
88	respiratory chain complex IV assembly (GO:0008535)	2.61391013
89	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59599555
90	negative regulation of macrophage differentiation (GO:0045650)	2.58959979
91	tryptophan metabolic process (GO:0006568)	2.58004986
92	alkaloid metabolic process (GO:0009820)	2.54809999
93	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.54723754
94	protein polyglutamylation (GO:0018095)	2.52411637
95	UTP metabolic process (GO:0046051)	2.52110053
96	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.51889510
97	benzene-containing compound metabolic process (GO:0042537)	2.51111670
98	regulation of cellular respiration (GO:0043457)	2.50426523
99	regulation of microtubule-based movement (GO:0060632)	2.48837376
100	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.48505212

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.37872208
2	VDR_22108803_ChIP-Seq_LS180_Human	4.36449751
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.28585957
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.07010631
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94405594
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.81511261
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80805440
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74112262
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58063244
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.49028758
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20466170
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.16542667
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16075766
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.13736741
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.13358959
16	VDR_23849224_ChIP-Seq_CD4+_Human	1.86306087
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86051461
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80462334
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.79222809
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73608531
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72487869
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.65623183
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60894380
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.60715088
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57150044
26	FUS_26573619_Chip-Seq_HEK293_Human	1.54049047
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.52821493
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48619888
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47337207
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46943043
31	EWS_26573619_Chip-Seq_HEK293_Human	1.46919794
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46606235
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44467112
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42482459
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42182378
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40380432
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.37059622
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.36821120
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.33186109
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30881409
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28751169
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28416773
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.28416773
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26562499
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26409545
46	IGF1R_20145208_ChIP-Seq_DFB_Human	1.25724643
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22504829
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22467781
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22153248
50	P300_19829295_ChIP-Seq_ESCs_Human	1.22114769
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21656173
52	NCOR_22424771_ChIP-Seq_293T_Human	1.20411518
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.16819878
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.16482769
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14674656
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14234421
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13545673
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12544056
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12028428
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12028428
61	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.10825796
62	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06487746
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05162685
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04624487
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04445174
66	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.02936280
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.02249856
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.01329674
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00908079
70	TTF2_22483619_ChIP-Seq_HELA_Human	1.00839242
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99436188
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99020728
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99012320
74	AR_20517297_ChIP-Seq_VCAP_Human	0.97938235
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97659797
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97099788
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95043104
78	ERG_20517297_ChIP-Seq_VCAP_Human	0.94263266
79	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94041478
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94041478
81	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93917511
82	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93178987
83	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.89900130
84	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89710487
85	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.89138208
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88625129
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.87569351
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.87193326
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86489519
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86484459
91	SMAD4_21799915_ChIP-Seq_A2780_Human	0.86364740
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.86132946
93	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.86097001
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.85508141
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84527652
96	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.84168251
97	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.84024689
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.82673609
99	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.82559220
100	BCL6_27268052_Chip-Seq_Bcells_Human	0.82292018

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.37265608
2	MP0002102_abnormal_ear_morphology	2.92264740
3	MP0004142_abnormal_muscle_tone	2.85226413
4	MP0003646_muscle_fatigue	2.83707861
5	MP0001968_abnormal_touch/_nociception	2.81572034
6	MP0008872_abnormal_physiological_respon	2.69454776
7	MP0009379_abnormal_foot_pigmentation	2.68301876
8	MP0008875_abnormal_xenobiotic_pharmacok	2.53349576
9	MP0003787_abnormal_imprinting	2.42106811
10	MP0001529_abnormal_vocalization	2.36149905
11	MP0004145_abnormal_muscle_electrophysio	2.23461129
12	MP0003121_genomic_imprinting	2.21230396
13	MP0008877_abnormal_DNA_methylation	2.13930701
14	MP0006292_abnormal_olfactory_placode	2.10523365
15	MP0005645_abnormal_hypothalamus_physiol	2.03897800
16	MP0008058_abnormal_DNA_repair	2.02499115
17	MP0006072_abnormal_retinal_apoptosis	1.95195091
18	MP0005551_abnormal_eye_electrophysiolog	1.91574765
19	MP0002876_abnormal_thyroid_physiology	1.89530940
20	MP0006276_abnormal_autonomic_nervous	1.85159529
21	MP0002736_abnormal_nociception_after	1.82423123
22	MP0002234_abnormal_pharynx_morphology	1.80974450
23	MP0001905_abnormal_dopamine_level	1.71815048
24	MP0002733_abnormal_thermal_nociception	1.70339807
25	MP0001986_abnormal_taste_sensitivity	1.68933729
26	MP0001835_abnormal_antigen_presentation	1.68695246
27	MP0005671_abnormal_response_to	1.64349384
28	MP0002272_abnormal_nervous_system	1.61934587
29	MP0009745_abnormal_behavioral_response	1.59368869
30	MP0005646_abnormal_pituitary_gland	1.57689373
31	MP0001984_abnormal_olfaction	1.56919711
32	MP0008789_abnormal_olfactory_epithelium	1.52750471
33	MP0001970_abnormal_pain_threshold	1.52653067
34	MP0003195_calcinosis	1.52257350
35	MP0001440_abnormal_grooming_behavior	1.50789585
36	MP0003880_abnormal_central_pattern	1.48651074
37	MP0009046_muscle_twitch	1.48420885
38	MP0001486_abnormal_startle_reflex	1.37682597
39	MP0003186_abnormal_redox_activity	1.37221842
40	MP0005423_abnormal_somatic_nervous	1.36471265
41	MP0002572_abnormal_emotion/affect_behav	1.36220557
42	MP0002638_abnormal_pupillary_reflex	1.34938815
43	MP0006036_abnormal_mitochondrial_physio	1.33248116
44	MP0005394_taste/olfaction_phenotype	1.32997448
45	MP0005499_abnormal_olfactory_system	1.32997448
46	MP0001348_abnormal_lacrimal_gland	1.31983485
47	MP0000631_abnormal_neuroendocrine_gland	1.29742204
48	MP0002653_abnormal_ependyma_morphology	1.29258646
49	MP0005253_abnormal_eye_physiology	1.28686609
50	MP0002751_abnormal_autonomic_nervous	1.28638717
51	MP0002557_abnormal_social/conspecific_i	1.26998274
52	MP0002734_abnormal_mechanical_nocicepti	1.24459265
53	MP0008995_early_reproductive_senescence	1.24036008
54	MP0005084_abnormal_gallbladder_morpholo	1.23344320
55	MP0004924_abnormal_behavior	1.21913045
56	MP0005386_behavior/neurological_phenoty	1.21913045
57	MP0003718_maternal_effect	1.20756861
58	MP0002063_abnormal_learning/memory/cond	1.20536524
59	MP0004885_abnormal_endolymph	1.19527263
60	MP0002735_abnormal_chemical_nociception	1.18748606
61	MP0003635_abnormal_synaptic_transmissio	1.18741651
62	MP0005075_abnormal_melanosome_morpholog	1.14561483
63	MP0004147_increased_porphyrin_level	1.11829325
64	MP0001293_anophthalmia	1.11717026
65	MP0004742_abnormal_vestibular_system	1.10471632
66	MP0002184_abnormal_innervation	1.09362438
67	MP0002138_abnormal_hepatobiliary_system	1.09122642
68	MP0002837_dystrophic_cardiac_calcinosis	1.08947298
69	MP0003011_delayed_dark_adaptation	1.05169457
70	MP0003724_increased_susceptibility_to	1.00166971
71	MP0002752_abnormal_somatic_nervous	0.96231993
72	MP0006035_abnormal_mitochondrial_morpho	0.95831295
73	MP0005195_abnormal_posterior_eye	0.95145325
74	MP0000372_irregular_coat_pigmentation	0.95116788
75	MP0003137_abnormal_impulse_conducting	0.91670101
76	MP0005167_abnormal_blood-brain_barrier	0.88631028
77	MP0004859_abnormal_synaptic_plasticity	0.88450056
78	MP0005389_reproductive_system_phenotype	0.88300932
79	MP0002160_abnormal_reproductive_system	0.88282065
80	MP0002064_seizures	0.87304108
81	MP0002067_abnormal_sensory_capabilities	0.85899648
82	MP0001188_hyperpigmentation	0.81868969
83	MP0004133_heterotaxia	0.81669574
84	MP0001485_abnormal_pinna_reflex	0.80423201
85	MP0000955_abnormal_spinal_cord	0.78699186
86	MP0001800_abnormal_humoral_immune	0.78269092
87	MP0005503_abnormal_tendon_morphology	0.77528301
88	MP0003786_premature_aging	0.75699615
89	MP0001929_abnormal_gametogenesis	0.75626982
90	MP0000685_abnormal_immune_system	0.74933113
91	MP0001963_abnormal_hearing_physiology	0.74392946
92	MP0002229_neurodegeneration	0.72840422
93	MP0003890_abnormal_embryonic-extraembry	0.72658526
94	MP0003567_abnormal_fetal_cardiomyocyte	0.72481722
95	MP0001324_abnormal_eye_pigmentation	0.72415388
96	MP0001790_abnormal_immune_system	0.72378985
97	MP0005387_immune_system_phenotype	0.72378985
98	MP0003119_abnormal_digestive_system	0.70879211
99	MP0001764_abnormal_homeostasis	0.70327264
100	MP0002210_abnormal_sex_determination	0.69963962

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.33832172
2	Colon cancer (HP:0003003)	4.23015331
3	Acute necrotizing encephalopathy (HP:0006965)	3.86815560
4	Abnormality of midbrain morphology (HP:0002418)	3.83303888
5	Molar tooth sign on MRI (HP:0002419)	3.83303888
6	Mitochondrial inheritance (HP:0001427)	3.64316369
7	Congenital, generalized hypertrichosis (HP:0004540)	3.62973354
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.62369297
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57214446
10	Increased CSF lactate (HP:0002490)	3.43480613
11	Acute encephalopathy (HP:0006846)	3.36750460
12	Hepatocellular necrosis (HP:0001404)	3.31396819
13	Pancreatic cysts (HP:0001737)	3.30127627
14	Chronic hepatic failure (HP:0100626)	3.29801718
15	Congenital stationary night blindness (HP:0007642)	3.29294403
16	Polyphagia (HP:0002591)	3.23414191
17	Abnormal number of erythroid precursors (HP:0012131)	3.23299509
18	Hepatic necrosis (HP:0002605)	3.22997872
19	Abnormality of the labia minora (HP:0012880)	3.21067059
20	Progressive macrocephaly (HP:0004481)	3.12940353
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.96603100
22	Increased hepatocellular lipid droplets (HP:0006565)	2.92656557
23	Lipid accumulation in hepatocytes (HP:0006561)	2.86565632
24	Increased IgM level (HP:0003496)	2.86171850
25	Pancreatic fibrosis (HP:0100732)	2.84394491
26	True hermaphroditism (HP:0010459)	2.83231764
27	Optic disc pallor (HP:0000543)	2.78817374
28	Stomach cancer (HP:0012126)	2.76037641
29	Attenuation of retinal blood vessels (HP:0007843)	2.69557646
30	Retinal dysplasia (HP:0007973)	2.68213180
31	Medial flaring of the eyebrow (HP:0010747)	2.68016946
32	Abnormality of alanine metabolism (HP:0010916)	2.67254286
33	Hyperalaninemia (HP:0003348)	2.67254286
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.67254286
35	Type II lissencephaly (HP:0007260)	2.67203045
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65922525
37	Nephronophthisis (HP:0000090)	2.58388345
38	Abnormality of B cell number (HP:0010975)	2.55687240
39	Autoimmune thrombocytopenia (HP:0001973)	2.49203910
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.48195892
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.41849312
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.41849312
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.41631076
44	Abnormal hemoglobin (HP:0011902)	2.37829686
45	Increased intramyocellular lipid droplets (HP:0012240)	2.35922379
46	Abnormality of the renal cortex (HP:0011035)	2.35713460
47	Thyroid-stimulating hormone excess (HP:0002925)	2.35417636
48	Increased serum lactate (HP:0002151)	2.35251858
49	Abolished electroretinogram (ERG) (HP:0000550)	2.35010666
50	IgG deficiency (HP:0004315)	2.32987435
51	Reticulocytopenia (HP:0001896)	2.31032785
52	Myokymia (HP:0002411)	2.30687633
53	Macrocytic anemia (HP:0001972)	2.30273937
54	Pallor (HP:0000980)	2.24031081
55	Stomatitis (HP:0010280)	2.23598793
56	Cerebral edema (HP:0002181)	2.21957984
57	Oligomenorrhea (HP:0000876)	2.21043511
58	Glycosuria (HP:0003076)	2.20649975
59	Abnormality of urine glucose concentration (HP:0011016)	2.20649975
60	Exertional dyspnea (HP:0002875)	2.20286563
61	Lactic acidosis (HP:0003128)	2.19566314
62	Asplenia (HP:0001746)	2.17534193
63	Abnormality of the renal medulla (HP:0100957)	2.16145678
64	Methylmalonic acidemia (HP:0002912)	2.15989371
65	Renal Fanconi syndrome (HP:0001994)	2.12235781
66	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11227083
67	Pachygyria (HP:0001302)	2.10927241
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08125341
69	Abnormality of the prostate (HP:0008775)	2.06919648
70	Sclerocornea (HP:0000647)	2.06072521
71	Decreased central vision (HP:0007663)	2.05902892
72	Gait imbalance (HP:0002141)	2.05806826
73	Increased muscle lipid content (HP:0009058)	2.05031831
74	Respiratory failure (HP:0002878)	2.02990813
75	Methylmalonic aciduria (HP:0012120)	2.01715836
76	Pendular nystagmus (HP:0012043)	1.99022956
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98531608
78	Renal cortical cysts (HP:0000803)	1.89635233
79	Absent thumb (HP:0009777)	1.89293268
80	Lissencephaly (HP:0001339)	1.88336871
81	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.87783262
82	Absent/shortened dynein arms (HP:0200106)	1.87783262
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87239911
84	Cystic liver disease (HP:0006706)	1.84200684
85	Congenital primary aphakia (HP:0007707)	1.83773817
86	Failure to thrive in infancy (HP:0001531)	1.83078470
87	Agitation (HP:0000713)	1.82311267
88	Leukodystrophy (HP:0002415)	1.81275500
89	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.80525450
90	Lethargy (HP:0001254)	1.80127596
91	Nephrogenic diabetes insipidus (HP:0009806)	1.79730787
92	Aplastic anemia (HP:0001915)	1.78512859
93	Exercise intolerance (HP:0003546)	1.77790831
94	Stenosis of the external auditory canal (HP:0000402)	1.76597004
95	Supernumerary spleens (HP:0009799)	1.76338535
96	Generalized aminoaciduria (HP:0002909)	1.74737919
97	Abnormal eating behavior (HP:0100738)	1.73689740
98	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.72750779
99	Broad-based gait (HP:0002136)	1.72506283
100	Abnormal hair whorl (HP:0010721)	1.70258328

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.46789597
2	VRK2	3.34982974
3	MAP4K2	2.90970085
4	STK16	2.68341077
5	FRK	2.64718730
6	ADRBK2	2.51420172
7	CAMKK2	2.30170958
8	GRK1	2.07563146
9	NUAK1	1.93146333
10	DYRK2	1.91381652
11	DAPK2	1.87220570
12	PDK2	1.84375740
13	INSRR	1.82073181
14	TLK1	1.78184816
15	TIE1	1.62464615
16	CSNK1G3	1.56055883
17	DAPK1	1.54061291
18	WNK4	1.47350164
19	TRIM28	1.43412314
20	MARK1	1.41919673
21	CSNK1G1	1.36754776
22	TXK	1.36644506
23	ADRBK1	1.34643561
24	CSNK1A1L	1.32949821
25	BCR	1.31499040
26	BCKDK	1.31180159
27	KIT	1.31150031
28	CSNK1G2	1.29933442
29	EPHA4	1.24715052
30	BMPR1B	1.23967666
31	CAMKK1	1.20682998
32	PHKG2	1.20017829
33	PHKG1	1.20017829
34	MAP3K12	1.15947472
35	WNK3	1.15902435
36	MAP3K4	1.15143501
37	NEK1	1.15027646
38	NTRK2	1.13484914
39	PAK3	1.12678687
40	VRK1	1.12147380
41	NME1	1.10769043
42	TAOK3	1.10737769
43	PASK	1.09703279
44	PAK6	1.08302947
45	MAPK13	1.06193564
46	PRKCG	1.05869387
47	MAP2K7	1.05172747
48	ZAK	1.02100156
49	PLK4	0.97899585
50	TEC	0.94340173
51	SRPK1	0.78576669
52	RPS6KA5	0.77633111
53	FLT3	0.76450591
54	CDC7	0.76419597
55	TAF1	0.75061658
56	SYK	0.73529789
57	CCNB1	0.71314635
58	DAPK3	0.71005800
59	GRK7	0.69207945
60	ATR	0.68186515
61	SIK2	0.68108001
62	OXSR1	0.67993970
63	MINK1	0.67829823
64	IKBKB	0.67681867
65	NME2	0.66285347
66	STK39	0.65237140
67	CDK19	0.62006825
68	CAMK2A	0.61787974
69	ITK	0.60387843
70	CAMK1	0.58996653
71	PKN1	0.58952019
72	MKNK1	0.58339045
73	PRKCE	0.57709563
74	FES	0.56784505
75	RPS6KA6	0.55733743
76	CSNK2A2	0.53448130
77	PRKACA	0.52693136
78	MKNK2	0.51991400
79	PIK3CG	0.51431747
80	MAPK15	0.50773848
81	TSSK6	0.50234294
82	OBSCN	0.50176287
83	MAPKAPK5	0.49688711
84	MAP2K2	0.49526254
85	PIK3CA	0.48484584
86	LIMK1	0.48372252
87	GRK5	0.43732300
88	CSNK2A1	0.43020844
89	RPS6KB2	0.42762316
90	DYRK1A	0.41991416
91	MAP3K11	0.40452933
92	MARK3	0.40254902
93	AKT3	0.39676645
94	CSNK1A1	0.39595846
95	PRKCI	0.39569498
96	NTRK3	0.37572650
97	CSNK1E	0.37018617
98	PLK2	0.36456136
99	PRKCZ	0.36195054
100	PRKCA	0.35388371

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.44441767
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.77353254
3	Asthma_Homo sapiens_hsa05310	3.07094108
4	Parkinsons disease_Homo sapiens_hsa05012	3.04416595
5	RNA polymerase_Homo sapiens_hsa03020	2.99254084
6	Allograft rejection_Homo sapiens_hsa05330	2.55904411
7	Protein export_Homo sapiens_hsa03060	2.55155654
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.39311424
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.22806782
10	Proteasome_Homo sapiens_hsa03050	2.20875787
11	Huntingtons disease_Homo sapiens_hsa05016	2.16619730
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.09586948
13	Alzheimers disease_Homo sapiens_hsa05010	2.05307422
14	Phototransduction_Homo sapiens_hsa04744	2.00056090
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88804556
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88431486
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.77233798
18	Regulation of autophagy_Homo sapiens_hsa04140	1.74131494
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.73059623
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72279266
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.68300861
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67220198
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.56215076
24	RNA degradation_Homo sapiens_hsa03018	1.51327585
25	Caffeine metabolism_Homo sapiens_hsa00232	1.46827699
26	Butanoate metabolism_Homo sapiens_hsa00650	1.43571063
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42849089
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.39848743
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35866748
30	Basal transcription factors_Homo sapiens_hsa03022	1.31160571
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.26763524
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26445548
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17740496
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13884114
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.11093469
36	Homologous recombination_Homo sapiens_hsa03440	1.08393108
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99834901
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98939282
39	Olfactory transduction_Homo sapiens_hsa04740	0.98548424
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98492224
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97930374
42	Peroxisome_Homo sapiens_hsa04146	0.95078763
43	Base excision repair_Homo sapiens_hsa03410	0.94388202
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93498887
45	Purine metabolism_Homo sapiens_hsa00230	0.93244371
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.90408343
47	Nicotine addiction_Homo sapiens_hsa05033	0.90131321
48	One carbon pool by folate_Homo sapiens_hsa00670	0.88124341
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.87991047
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87124122
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86170427
52	Taste transduction_Homo sapiens_hsa04742	0.77775966
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76332610
54	Viral myocarditis_Homo sapiens_hsa05416	0.75759956
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.74143380
56	Propanoate metabolism_Homo sapiens_hsa00640	0.73521977
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73491842
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73078501
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72346379
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.71547109
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69660285
62	Metabolic pathways_Homo sapiens_hsa01100	0.69387680
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.68262111
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68210520
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66884787
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.65239475
67	Glutathione metabolism_Homo sapiens_hsa00480	0.60259772
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.58157086
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58055229
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57439745
71	Fatty acid degradation_Homo sapiens_hsa00071	0.56647034
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55235100
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55233600
74	Morphine addiction_Homo sapiens_hsa05032	0.54272101
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52855100
76	RNA transport_Homo sapiens_hsa03013	0.50231269
77	Spliceosome_Homo sapiens_hsa03040	0.49235502
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49097367
79	Fatty acid elongation_Homo sapiens_hsa00062	0.49074952
80	Retinol metabolism_Homo sapiens_hsa00830	0.46736608
81	Serotonergic synapse_Homo sapiens_hsa04726	0.45532736
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.45088966
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44661581
84	GABAergic synapse_Homo sapiens_hsa04727	0.42676229
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42110496
86	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42067918
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.41712111
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.41669021
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41256816
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39913803
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38751568
92	Folate biosynthesis_Homo sapiens_hsa00790	0.37600061
93	Mismatch repair_Homo sapiens_hsa03430	0.37556583
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.36813051
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35772761
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35167114
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.34422548
98	Salivary secretion_Homo sapiens_hsa04970	0.30483758
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29371850
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.28440298

RPS3AP29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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