ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.88287872
2	positive regulation of immune response to tumor cell (GO:0002839)	5.19606091
3	regulation of immune response to tumor cell (GO:0002837)	5.19606091
4	regulation of response to tumor cell (GO:0002834)	5.19606091
5	positive regulation of response to tumor cell (GO:0002836)	5.19606091
6	regulation of cilium movement (GO:0003352)	5.00698452
7	piRNA metabolic process (GO:0034587)	4.99587369
8	negative regulation of telomere maintenance (GO:0032205)	4.81196832
9	neuronal action potential propagation (GO:0019227)	4.59795320
10	lysine catabolic process (GO:0006554)	4.58328773
11	lysine metabolic process (GO:0006553)	4.58328773
12	behavioral response to nicotine (GO:0035095)	4.17369407
13	proline biosynthetic process (GO:0006561)	4.05430401
14	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.98863834
15	isotype switching (GO:0045190)	3.98863834
16	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.98863834
17	nonmotile primary cilium assembly (GO:0035058)	3.94870437
18	negative regulation of telomerase activity (GO:0051974)	3.89145109
19	regulation of microtubule-based movement (GO:0060632)	3.85774486
20	cullin deneddylation (GO:0010388)	3.84856028
21	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.81420200
22	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	3.79610403
23	regulation of telomere maintenance via telomerase (GO:0032210)	3.77073070
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.71127866
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.71127866
26	seminiferous tubule development (GO:0072520)	3.64024980
27	C4-dicarboxylate transport (GO:0015740)	3.58951556
28	positive regulation by host of viral transcription (GO:0043923)	3.49069799
29	axoneme assembly (GO:0035082)	3.48332324
30	indolalkylamine metabolic process (GO:0006586)	3.44980026
31	protein deneddylation (GO:0000338)	3.44765638
32	DNA double-strand break processing (GO:0000729)	3.44640705
33	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.35805552
34	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34895063
35	ribosomal large subunit biogenesis (GO:0042273)	3.31196866
36	viral transcription (GO:0019083)	3.29071096
37	protein neddylation (GO:0045116)	3.25528823
38	translational termination (GO:0006415)	3.22050546
39	aspartate family amino acid catabolic process (GO:0009068)	3.21697158
40	cornea development in camera-type eye (GO:0061303)	3.18210790
41	synaptic transmission, cholinergic (GO:0007271)	3.18025120
42	positive regulation of muscle cell apoptotic process (GO:0010661)	3.15443244
43	ribosomal small subunit biogenesis (GO:0042274)	3.14806089
44	regulation of telomerase activity (GO:0051972)	3.14106370
45	negative regulation of response to food (GO:0032096)	3.10526978
46	negative regulation of appetite (GO:0032099)	3.10526978
47	tryptophan metabolic process (GO:0006568)	3.04181230
48	negative regulation by host of viral transcription (GO:0043922)	2.97598015
49	reciprocal meiotic recombination (GO:0007131)	2.95535159
50	reciprocal DNA recombination (GO:0035825)	2.95535159
51	lymphoid progenitor cell differentiation (GO:0002320)	2.93635401
52	replication fork processing (GO:0031297)	2.92705338
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.89384738
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86132073
55	platelet dense granule organization (GO:0060155)	2.86013464
56	proline metabolic process (GO:0006560)	2.83173999
57	endoderm formation (GO:0001706)	2.80721772
58	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.79711166
59	regulation of telomere maintenance (GO:0032204)	2.78985639
60	head development (GO:0060322)	2.76507959
61	translational elongation (GO:0006414)	2.74769186
62	brain morphogenesis (GO:0048854)	2.74711059
63	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74373235
64	response to pheromone (GO:0019236)	2.72953465
65	cotranslational protein targeting to membrane (GO:0006613)	2.72785661
66	left/right axis specification (GO:0070986)	2.72337011
67	motile cilium assembly (GO:0044458)	2.70787652
68	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.69562352
69	protein targeting to ER (GO:0045047)	2.69147147
70	protein K6-linked ubiquitination (GO:0085020)	2.68971377
71	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.68143519
72	spermatid development (GO:0007286)	2.65997556
73	maintenance of protein location in nucleus (GO:0051457)	2.65678522
74	somite development (GO:0061053)	2.64932649
75	glyoxylate metabolic process (GO:0046487)	2.64321772
76	chaperone-mediated protein transport (GO:0072321)	2.62908424
77	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.62004030
78	negative regulation of interleukin-17 production (GO:0032700)	2.61297607
79	DNA methylation involved in gamete generation (GO:0043046)	2.59965093
80	melanosome transport (GO:0032402)	2.59127816
81	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.59058473
82	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.58042500
83	alanine transport (GO:0032328)	2.55417916
84	protein import into peroxisome matrix (GO:0016558)	2.54690541
85	establishment of melanosome localization (GO:0032401)	2.54661807
86	regulation of smooth muscle cell apoptotic process (GO:0034391)	2.54376420
87	protein localization to endoplasmic reticulum (GO:0070972)	2.52864313
88	protein-cofactor linkage (GO:0018065)	2.51058280
89	pigment granule transport (GO:0051904)	2.50132591
90	positive regulation of translational initiation (GO:0045948)	2.49744336
91	L-serine metabolic process (GO:0006563)	2.47767158
92	somatic diversification of immunoglobulins (GO:0016445)	2.47594988
93	primitive streak formation (GO:0090009)	2.46465444
94	establishment of pigment granule localization (GO:0051905)	2.46251853
95	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.44320925
96	NADH dehydrogenase complex assembly (GO:0010257)	2.44320925
97	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.44320925
98	indole-containing compound metabolic process (GO:0042430)	2.43810382
99	olfactory bulb development (GO:0021772)	2.43668459
100	intraciliary transport (GO:0042073)	2.43023916

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.73808522
2	VDR_22108803_ChIP-Seq_LS180_Human	3.64705841
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.99982701
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83850428
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.42024740
6	FUS_26573619_Chip-Seq_HEK293_Human	2.34115109
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33610902
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33109901
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32752200
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.32333019
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24303821
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.16525842
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.15361065
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.07861786
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06114437
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02389228
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.90202892
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83874883
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.82704177
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.82496218
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.82305699
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.78683432
23	P300_19829295_ChIP-Seq_ESCs_Human	1.75539558
24	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.72066592
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.65955641
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.64174214
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61613794
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.60671331
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.56992921
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55801066
31	GATA1_22025678_ChIP-Seq_K562_Human	1.55279286
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53617250
33	EWS_26573619_Chip-Seq_HEK293_Human	1.53371013
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52004896
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51058486
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.48539930
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47579478
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47249366
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47044300
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45984665
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.43770434
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.42195463
43	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40183856
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38513565
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.37338735
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36005065
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.33064413
48	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.32767516
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31603308
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26008191
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25390643
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22893828
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21465327
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19623286
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.16650538
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16650538
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16358708
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15373207
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13056948
60	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.11757639
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.11728760
62	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11472402
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11296739
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11267042
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09469734
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09248832
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09095769
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08118799
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08015743
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08015743
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07606092
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.06265043
73	P300_18555785_Chip-Seq_ESCs_Mouse	1.05688293
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05210363
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04977376
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04506769
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04453254
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04100534
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04100534
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03986441
81	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02924969
82	STAT3_23295773_ChIP-Seq_U87_Human	1.02852605
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02484813
84	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00971230
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00561514
86	NCOR_22424771_ChIP-Seq_293T_Human	1.00173257
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00165614
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00017346
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99912776
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98570362
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97972356
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.97972356
93	TCF4_23295773_ChIP-Seq_U87_Human	0.97822584
94	AR_20517297_ChIP-Seq_VCAP_Human	0.97267380
95	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97161190
96	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.96687925
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96530086
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96293138
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95517279
100	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.95097125

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.00479138
2	MP0002736_abnormal_nociception_after	3.49387037
3	MP0005075_abnormal_melanosome_morpholog	3.32727985
4	MP0004147_increased_porphyrin_level	2.92164450
5	MP0001968_abnormal_touch/_nociception	2.83160576
6	MP0005174_abnormal_tail_pigmentation	2.58534662
7	MP0001984_abnormal_olfaction	2.56808749
8	MP0008877_abnormal_DNA_methylation	2.53690439
9	MP0004133_heterotaxia	2.45732428
10	MP0005645_abnormal_hypothalamus_physiol	2.31281694
11	MP0003880_abnormal_central_pattern	2.28705889
12	MP0003136_yellow_coat_color	2.27956883
13	MP0006072_abnormal_retinal_apoptosis	2.15481711
14	MP0008872_abnormal_physiological_respon	2.14479136
15	MP0003787_abnormal_imprinting	2.11001248
16	MP0008789_abnormal_olfactory_epithelium	2.10883274
17	MP0005499_abnormal_olfactory_system	2.07790249
18	MP0005394_taste/olfaction_phenotype	2.07790249
19	MP0001188_hyperpigmentation	2.01680887
20	MP0004145_abnormal_muscle_electrophysio	1.98798851
21	MP0008058_abnormal_DNA_repair	1.97431778
22	MP0005646_abnormal_pituitary_gland	1.97058768
23	MP0004885_abnormal_endolymph	1.94851145
24	MP0002938_white_spotting	1.93522741
25	MP0005670_abnormal_white_adipose	1.84035257
26	MP0000372_irregular_coat_pigmentation	1.77933904
27	MP0002160_abnormal_reproductive_system	1.74825815
28	MP0001293_anophthalmia	1.68304219
29	MP0002102_abnormal_ear_morphology	1.65872874
30	MP0002233_abnormal_nose_morphology	1.62105283
31	MP0005551_abnormal_eye_electrophysiolog	1.61672580
32	MP0001529_abnormal_vocalization	1.61083461
33	MP0002272_abnormal_nervous_system	1.57177394
34	MP0002653_abnormal_ependyma_morphology	1.55940529
35	MP0001486_abnormal_startle_reflex	1.52138337
36	MP0002572_abnormal_emotion/affect_behav	1.47471075
37	MP0001986_abnormal_taste_sensitivity	1.44500447
38	MP0003122_maternal_imprinting	1.40660995
39	MP0002638_abnormal_pupillary_reflex	1.38468063
40	MP0001440_abnormal_grooming_behavior	1.35624938
41	MP0005253_abnormal_eye_physiology	1.35256857
42	MP0003890_abnormal_embryonic-extraembry	1.35037762
43	MP0004215_abnormal_myocardial_fiber	1.34508540
44	MP0002095_abnormal_skin_pigmentation	1.34192537
45	MP0003567_abnormal_fetal_cardiomyocyte	1.32285426
46	MP0000631_abnormal_neuroendocrine_gland	1.27944558
47	MP0005389_reproductive_system_phenotype	1.24055747
48	MP0003195_calcinosis	1.19773600
49	MP0006276_abnormal_autonomic_nervous	1.18527004
50	MP0003121_genomic_imprinting	1.18253096
51	MP0001970_abnormal_pain_threshold	1.17145367
52	MP0002557_abnormal_social/conspecific_i	1.15655641
53	MP0002067_abnormal_sensory_capabilities	1.12703595
54	MP0004142_abnormal_muscle_tone	1.12316047
55	MP0002733_abnormal_thermal_nociception	1.08072720
56	MP0005084_abnormal_gallbladder_morpholo	1.07045773
57	MP0000778_abnormal_nervous_system	1.05789719
58	MP0010094_abnormal_chromosome_stability	1.05003794
59	MP0001929_abnormal_gametogenesis	1.04831572
60	MP0002734_abnormal_mechanical_nocicepti	1.03010857
61	MP0005195_abnormal_posterior_eye	1.02515603
62	MP0002229_neurodegeneration	1.02341733
63	MP0002163_abnormal_gland_morphology	1.00592541
64	MP0000569_abnormal_digit_pigmentation	0.97812782
65	MP0000427_abnormal_hair_cycle	0.97807973
66	MP0005257_abnormal_intraocular_pressure	0.97137272
67	MP0003698_abnormal_male_reproductive	0.97072499
68	MP0003119_abnormal_digestive_system	0.95542564
69	MP0002752_abnormal_somatic_nervous	0.95364875
70	MP0001324_abnormal_eye_pigmentation	0.95238530
71	MP0001145_abnormal_male_reproductive	0.94762471
72	MP0003937_abnormal_limbs/digits/tail_de	0.92742135
73	MP0003011_delayed_dark_adaptation	0.91737861
74	MP0005377_hearing/vestibular/ear_phenot	0.91720408
75	MP0003878_abnormal_ear_physiology	0.91720408
76	MP0002210_abnormal_sex_determination	0.91554360
77	MP0009745_abnormal_behavioral_response	0.90249459
78	MP0001963_abnormal_hearing_physiology	0.90055958
79	MP0002928_abnormal_bile_duct	0.89886405
80	MP0009765_abnormal_xenobiotic_induced	0.89314726
81	MP0002063_abnormal_learning/memory/cond	0.88875748
82	MP0002184_abnormal_innervation	0.85660508
83	MP0003635_abnormal_synaptic_transmissio	0.83690418
84	MP0000653_abnormal_sex_gland	0.83111630
85	MP0001119_abnormal_female_reproductive	0.82511827
86	MP0005423_abnormal_somatic_nervous	0.81613852
87	MP0002735_abnormal_chemical_nociception	0.81505972
88	MP0003137_abnormal_impulse_conducting	0.79783352
89	MP0001485_abnormal_pinna_reflex	0.79574800
90	MP0000026_abnormal_inner_ear	0.78262631
91	MP0003693_abnormal_embryo_hatching	0.77450533
92	MP0005410_abnormal_fertilization	0.77414591
93	MP0001286_abnormal_eye_development	0.77184541
94	MP0002876_abnormal_thyroid_physiology	0.76524317
95	MP0001664_abnormal_digestion	0.75002642
96	MP0002822_catalepsy	0.74436351
97	MP0000230_abnormal_systemic_arterial	0.74026236
98	MP0000049_abnormal_middle_ear	0.69839083
99	MP0004043_abnormal_pH_regulation	0.69124004
100	MP0005171_absent_coat_pigmentation	0.68288316

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.13065589
2	Molar tooth sign on MRI (HP:0002419)	4.13065589
3	Pancreatic fibrosis (HP:0100732)	3.83678358
4	Pancreatic cysts (HP:0001737)	3.62451648
5	Medial flaring of the eyebrow (HP:0010747)	3.60873981
6	Colon cancer (HP:0003003)	3.51587876
7	True hermaphroditism (HP:0010459)	3.51544344
8	Gait imbalance (HP:0002141)	3.23956752
9	Chronic hepatic failure (HP:0100626)	3.23040089
10	Volvulus (HP:0002580)	3.22068745
11	Progressive cerebellar ataxia (HP:0002073)	3.21489594
12	Congenital primary aphakia (HP:0007707)	3.03729692
13	Neoplasm of the adrenal cortex (HP:0100641)	2.98505770
14	Papilledema (HP:0001085)	2.97682733
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.88085530
16	Congenital stationary night blindness (HP:0007642)	2.86044743
17	Abnormal hemoglobin (HP:0011902)	2.83156250
18	Reticulocytopenia (HP:0001896)	2.82271138
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74219521
20	Constricted visual fields (HP:0001133)	2.73849373
21	Absent/shortened dynein arms (HP:0200106)	2.68792272
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68792272
23	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.67722695
24	Nephronophthisis (HP:0000090)	2.65289410
25	Nephrogenic diabetes insipidus (HP:0009806)	2.65147141
26	Hyperglycinemia (HP:0002154)	2.62974493
27	Bile duct proliferation (HP:0001408)	2.58599783
28	Abnormal biliary tract physiology (HP:0012439)	2.58599783
29	Genetic anticipation (HP:0003743)	2.54873385
30	Abnormality of the labia minora (HP:0012880)	2.54785156
31	Asplenia (HP:0001746)	2.53891925
32	Cystic liver disease (HP:0006706)	2.53299026
33	Abolished electroretinogram (ERG) (HP:0000550)	2.52954053
34	Oligodactyly (hands) (HP:0001180)	2.47048404
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.43922624
36	Abnormality of the renal medulla (HP:0100957)	2.43896002
37	Hyperglycinuria (HP:0003108)	2.42700293
38	Anencephaly (HP:0002323)	2.41413455
39	Sclerocornea (HP:0000647)	2.39292469
40	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.39055435
41	Decreased central vision (HP:0007663)	2.38409501
42	Abnormality of the nasal septum (HP:0000419)	2.35042137
43	Vaginal atresia (HP:0000148)	2.34656266
44	Congenital hepatic fibrosis (HP:0002612)	2.32292685
45	3-Methylglutaconic aciduria (HP:0003535)	2.32159140
46	Attenuation of retinal blood vessels (HP:0007843)	2.29840114
47	Abnormal hair whorl (HP:0010721)	2.28454149
48	Genital tract atresia (HP:0001827)	2.25415936
49	Gonadotropin excess (HP:0000837)	2.22831910
50	Supernumerary spleens (HP:0009799)	2.18642184
51	Abnormality of macular pigmentation (HP:0008002)	2.17756075
52	Pachygyria (HP:0001302)	2.14746629
53	Abnormality of serine family amino acid metabolism (HP:0010894)	2.12350579
54	Abnormality of glycine metabolism (HP:0010895)	2.12350579
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11122057
56	Type II lissencephaly (HP:0007260)	2.10002414
57	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09351724
58	Abnormality of the renal cortex (HP:0011035)	2.04825817
59	Gaze-evoked nystagmus (HP:0000640)	2.04148840
60	Abnormal number of erythroid precursors (HP:0012131)	2.03054699
61	Progressive inability to walk (HP:0002505)	2.03054071
62	Methylmalonic acidemia (HP:0002912)	2.02349334
63	Chronic bronchitis (HP:0004469)	2.00211198
64	Abnormality of serum amino acid levels (HP:0003112)	2.00161814
65	Optic disc pallor (HP:0000543)	2.00031419
66	Optic nerve coloboma (HP:0000588)	1.99610630
67	Inability to walk (HP:0002540)	1.96877547
68	Elevated erythrocyte sedimentation rate (HP:0003565)	1.96649840
69	Poor coordination (HP:0002370)	1.95969207
70	Broad foot (HP:0001769)	1.95039750
71	Cerebellar dysplasia (HP:0007033)	1.94238411
72	Myotonia (HP:0002486)	1.91643154
73	Erythroderma (HP:0001019)	1.91515126
74	Partial agenesis of the corpus callosum (HP:0001338)	1.91397035
75	Hyperalaninemia (HP:0003348)	1.90365155
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90365155
77	Abnormality of alanine metabolism (HP:0010916)	1.90365155
78	Parakeratosis (HP:0001036)	1.90149994
79	Multicystic kidney dysplasia (HP:0000003)	1.90057530
80	Intestinal atresia (HP:0011100)	1.89989402
81	Abnormal ciliary motility (HP:0012262)	1.89717564
82	Stenosis of the external auditory canal (HP:0000402)	1.88405604
83	Postaxial hand polydactyly (HP:0001162)	1.87738864
84	Macrocytic anemia (HP:0001972)	1.87018590
85	Panhypogammaglobulinemia (HP:0003139)	1.82409378
86	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.81387584
87	Adrenal hypoplasia (HP:0000835)	1.81071606
88	IgG deficiency (HP:0004315)	1.78510121
89	Horseshoe kidney (HP:0000085)	1.77053022
90	Abnormality of chromosome stability (HP:0003220)	1.76885117
91	Brushfield spots (HP:0001088)	1.76173701
92	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.75752659
93	Occipital encephalocele (HP:0002085)	1.75711505
94	Absent thumb (HP:0009777)	1.75048376
95	Abnormal drinking behavior (HP:0030082)	1.74745068
96	Polydipsia (HP:0001959)	1.74745068
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.74227247
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74227247
99	Muscle hypertrophy of the lower extremities (HP:0008968)	1.74111450
100	Renal cortical cysts (HP:0000803)	1.73673282

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.49487923
2	TAOK3	3.41674779
3	NME1	3.29847354
4	TRPM7	3.11271060
5	FRK	2.32655634
6	MKNK1	2.15354950
7	MAP2K6	2.09551927
8	ERBB4	2.02101946
9	WNK4	2.01356253
10	CDK19	1.94744919
11	MKNK2	1.91995768
12	KIT	1.89203690
13	ZAK	1.87144279
14	BMPR1B	1.85881546
15	EPHA4	1.85237489
16	GRK1	1.67196887
17	TRIM28	1.65569205
18	PBK	1.62671238
19	TLK1	1.61014627
20	NUAK1	1.53984862
21	PINK1	1.49786974
22	ACVR1B	1.43674472
23	OXSR1	1.41929187
24	BCKDK	1.38001215
25	TAF1	1.37509706
26	TNIK	1.35458717
27	PLK4	1.33203788
28	MAP3K6	1.31532883
29	FLT3	1.31198961
30	DAPK2	1.27497771
31	WNK3	1.25346239
32	MATK	1.20004577
33	ADRBK2	1.19312027
34	STK39	1.15088664
35	TIE1	1.14247977
36	MAPK13	1.13863644
37	BRSK2	1.13424511
38	CDC7	1.12446489
39	CAMKK2	1.12353719
40	NEK1	1.09888419
41	DYRK2	1.07175664
42	CSNK1G1	1.03707086
43	STK16	1.02289373
44	TNK2	1.00451849
45	NTRK2	1.00374392
46	VRK2	0.99533510
47	PRKCG	0.99433759
48	ADRBK1	0.90218714
49	PDK2	0.89863326
50	RPS6KA6	0.88807825
51	MAP2K4	0.87291449
52	CSNK1G2	0.85637955
53	RPS6KL1	0.83696106
54	RPS6KC1	0.83696106
55	GRK7	0.83133059
56	DAPK3	0.82604982
57	PRKCH	0.75237620
58	MAP3K4	0.74761760
59	BRSK1	0.74414985
60	NEK2	0.72440662
61	VRK1	0.70779615
62	MINK1	0.70421638
63	RPS6KB2	0.69345268
64	CSNK1A1L	0.65667014
65	PIK3CA	0.64892303
66	INSRR	0.64794712
67	PHKG2	0.63660752
68	PHKG1	0.63660752
69	CSNK1G3	0.60872291
70	SRPK1	0.60826240
71	MAP2K3	0.60313136
72	PLK2	0.59784197
73	ERBB3	0.59361321
74	MAPKAPK5	0.59341323
75	PLK3	0.58471004
76	PASK	0.58271207
77	CHEK2	0.55905783
78	PRKCQ	0.54121593
79	TEC	0.54060857
80	ATR	0.53907814
81	CAMKK1	0.53631532
82	CASK	0.51174489
83	SGK2	0.50025142
84	RPS6KA2	0.49720220
85	RPS6KB1	0.49095693
86	EIF2AK2	0.48997398
87	TGFBR1	0.48924794
88	ATM	0.48435849
89	SGK494	0.48020113
90	SGK223	0.48020113
91	PLK1	0.45590268
92	IRAK1	0.43536305
93	PAK3	0.42052025
94	PRKCE	0.41638414
95	MAP2K7	0.41255492
96	PAK6	0.40149664
97	FGFR2	0.39047592
98	DAPK1	0.37801024
99	AURKA	0.34159862
100	STK11	0.34158250

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.08879578
2	Ribosome_Homo sapiens_hsa03010	2.99817343
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.95923687
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.91392843
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.66067220
6	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.40468190
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.34908969
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34370547
9	Phototransduction_Homo sapiens_hsa04744	2.25368903
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24311315
11	Peroxisome_Homo sapiens_hsa04146	2.10796693
12	Butanoate metabolism_Homo sapiens_hsa00650	2.05007350
13	RNA polymerase_Homo sapiens_hsa03020	1.99458563
14	Homologous recombination_Homo sapiens_hsa03440	1.97224608
15	Basal transcription factors_Homo sapiens_hsa03022	1.94639962
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.90861898
17	Propanoate metabolism_Homo sapiens_hsa00640	1.82529369
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.80078137
19	Fatty acid elongation_Homo sapiens_hsa00062	1.74545196
20	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.69243458
21	RNA degradation_Homo sapiens_hsa03018	1.55795250
22	Fatty acid degradation_Homo sapiens_hsa00071	1.54901531
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.50990215
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.46459954
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46253558
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.45484096
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44674815
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42698723
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.36945874
30	Parkinsons disease_Homo sapiens_hsa05012	1.33349836
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30514678
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.29939988
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.28767147
34	Nicotine addiction_Homo sapiens_hsa05033	1.27004039
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.16506680
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.05255046
37	Protein export_Homo sapiens_hsa03060	1.02997562
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.01443497
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97809696
40	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97628653
41	Huntingtons disease_Homo sapiens_hsa05016	0.96156575
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95546256
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95188359
44	Taste transduction_Homo sapiens_hsa04742	0.89726610
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87963134
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87689933
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85918918
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85897479
49	Proteasome_Homo sapiens_hsa03050	0.85161488
50	Mismatch repair_Homo sapiens_hsa03430	0.84780825
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84495302
52	Olfactory transduction_Homo sapiens_hsa04740	0.82884080
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82423250
54	Regulation of autophagy_Homo sapiens_hsa04140	0.82232162
55	ABC transporters_Homo sapiens_hsa02010	0.81387636
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77214797
57	Mineral absorption_Homo sapiens_hsa04978	0.76500455
58	Purine metabolism_Homo sapiens_hsa00230	0.73884384
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.71893951
60	Alzheimers disease_Homo sapiens_hsa05010	0.71638671
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68234392
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.68019632
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64205207
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63390159
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.61448637
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61185925
67	African trypanosomiasis_Homo sapiens_hsa05143	0.61069154
68	Base excision repair_Homo sapiens_hsa03410	0.60388159
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60197624
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58845183
71	Allograft rejection_Homo sapiens_hsa05330	0.58781730
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.58070579
73	Metabolic pathways_Homo sapiens_hsa01100	0.58052347
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57474243
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57141593
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54796594
77	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54686509
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54076766
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53999574
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50880726
81	Serotonergic synapse_Homo sapiens_hsa04726	0.49834068
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49371272
83	Salivary secretion_Homo sapiens_hsa04970	0.47635893
84	Lysine degradation_Homo sapiens_hsa00310	0.46310262
85	One carbon pool by folate_Homo sapiens_hsa00670	0.46106902
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45444003
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41049763
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.40556357
89	Morphine addiction_Homo sapiens_hsa05032	0.40144649
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.39998529
91	RNA transport_Homo sapiens_hsa03013	0.38979430
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38821272
93	DNA replication_Homo sapiens_hsa03030	0.38566022
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36414803
95	Retinol metabolism_Homo sapiens_hsa00830	0.35957613
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.34374455
97	Spliceosome_Homo sapiens_hsa03040	0.32982495
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32592983
99	Circadian rhythm_Homo sapiens_hsa04710	0.31692250
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.31483797

RPS3AP30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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