ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.93741734
2	synapsis (GO:0007129)	4.35052865
3	behavioral response to nicotine (GO:0035095)	3.93578200
4	negative regulation of protein localization to cell surface (GO:2000009)	3.89437837
5	parturition (GO:0007567)	3.86523487
6	regulation of sarcomere organization (GO:0060297)	3.84319205
7	negative regulation of telomere maintenance (GO:0032205)	3.70107755
8	maturation of SSU-rRNA (GO:0030490)	3.58343152
9	ribonucleoprotein complex disassembly (GO:0032988)	3.55926500
10	male meiosis I (GO:0007141)	3.52519086
11	tongue development (GO:0043586)	3.51132647
12	spliceosomal complex assembly (GO:0000245)	3.49192776
13	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.44988227
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.43253942
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.43253942
16	NADH dehydrogenase complex assembly (GO:0010257)	3.43253942
17	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.43155754
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35669422
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.28455215
20	L-fucose catabolic process (GO:0042355)	3.26187052
21	fucose catabolic process (GO:0019317)	3.26187052
22	L-fucose metabolic process (GO:0042354)	3.26187052
23	ATP synthesis coupled proton transport (GO:0015986)	3.24415457
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.24415457
25	rRNA catabolic process (GO:0016075)	3.15544894
26	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.10908984
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.10908984
28	cerebral cortex radially oriented cell migration (GO:0021799)	3.08391720
29	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.07026716
30	regulation of action potential (GO:0098900)	3.06746435
31	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.02932020
32	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.01522790
33	meiosis I (GO:0007127)	3.00213731
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.00182895
35	protein complex biogenesis (GO:0070271)	3.00053386
36	positive regulation of growth hormone secretion (GO:0060124)	2.98305876
37	organelle disassembly (GO:1903008)	2.94159678
38	glycerophospholipid catabolic process (GO:0046475)	2.94098532
39	gamma-aminobutyric acid transport (GO:0015812)	2.93812318
40	mismatch repair (GO:0006298)	2.93286558
41	protein prenylation (GO:0018342)	2.92462933
42	prenylation (GO:0097354)	2.92462933
43	cellular response to ATP (GO:0071318)	2.91218615
44	DNA damage response, detection of DNA damage (GO:0042769)	2.91085113
45	presynaptic membrane assembly (GO:0097105)	2.91000124
46	positive regulation of microtubule polymerization (GO:0031116)	2.90927526
47	resolution of meiotic recombination intermediates (GO:0000712)	2.90401440
48	renal system development (GO:0072001)	2.90378907
49	negative regulation of muscle hypertrophy (GO:0014741)	2.88236762
50	platelet dense granule organization (GO:0060155)	2.87340269
51	protein neddylation (GO:0045116)	2.83876298
52	negative regulation of epidermal cell differentiation (GO:0045605)	2.80933693
53	recombinational repair (GO:0000725)	2.80331019
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77044896
55	nonmotile primary cilium assembly (GO:0035058)	2.76214141
56	DNA double-strand break processing (GO:0000729)	2.75366884
57	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.75234989
58	regulation of mitotic spindle checkpoint (GO:1903504)	2.75234989
59	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.74813767
60	negative regulation of heart growth (GO:0061117)	2.74813767
61	adaptation of signaling pathway (GO:0023058)	2.74795657
62	neurotransmitter catabolic process (GO:0042135)	2.74612808
63	indolalkylamine metabolic process (GO:0006586)	2.74433145
64	double-strand break repair via homologous recombination (GO:0000724)	2.74300963
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74284429
66	thalamus development (GO:0021794)	2.73358393
67	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.71547953
68	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.71547953
69	seminiferous tubule development (GO:0072520)	2.70553467
70	cell proliferation in forebrain (GO:0021846)	2.69883554
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67957170
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67389371
73	DNA deamination (GO:0045006)	2.66338571
74	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66033887
75	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.65888868
76	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.65842008
77	presynaptic membrane organization (GO:0097090)	2.64165498
78	negative regulation of organelle assembly (GO:1902116)	2.63864073
79	regulation of skeletal muscle contraction (GO:0014819)	2.61932256
80	head development (GO:0060322)	2.61741508
81	spinal cord association neuron differentiation (GO:0021527)	2.61194116
82	negative regulation of epidermis development (GO:0045683)	2.59834506
83	reciprocal DNA recombination (GO:0035825)	2.58562263
84	reciprocal meiotic recombination (GO:0007131)	2.58562263
85	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.58322919
86	substrate-independent telencephalic tangential migration (GO:0021826)	2.58322919
87	detection of light stimulus involved in sensory perception (GO:0050962)	2.56032393
88	detection of light stimulus involved in visual perception (GO:0050908)	2.56032393
89	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.55983908
90	somite development (GO:0061053)	2.54233442
91	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.54084800
92	regulation of timing of cell differentiation (GO:0048505)	2.53147680
93	adenosine metabolic process (GO:0046085)	2.52658310
94	positive regulation of respiratory burst (GO:0060267)	2.52388402
95	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51860884
96	drug catabolic process (GO:0042737)	2.51588797
97	epithelial cilium movement (GO:0003351)	2.50853536
98	mitotic cell cycle arrest (GO:0071850)	2.50418399
99	regulation of telomere maintenance via telomerase (GO:0032210)	2.49222811
100	regulation of meiosis I (GO:0060631)	2.48221628

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.49974044
2	VDR_22108803_ChIP-Seq_LS180_Human	3.77492418
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.66508680
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.19818160
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.83093559
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76799710
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59861391
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38595696
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.30374830
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29289126
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17311741
12	EWS_26573619_Chip-Seq_HEK293_Human	2.13665149
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10778395
14	FUS_26573619_Chip-Seq_HEK293_Human	2.09481808
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08064685
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.00826714
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.00410266
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94896658
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.89544979
20	P300_19829295_ChIP-Seq_ESCs_Human	1.88834972
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88551828
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.78871284
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.74553305
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73160714
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69728537
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.67511658
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64141161
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60793265
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.59684524
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.58096083
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54750181
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51394145
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50991844
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50554949
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.50554949
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48737619
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48538915
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48311449
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46354267
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46230157
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44922716
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.42997623
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.42084496
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40351807
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40278720
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40131462
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39907402
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.39738860
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.39531714
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38585503
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34499150
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.33887717
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32449466
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32449466
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29878724
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29878724
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27970758
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26589933
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22490055
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22295423
61	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20135247
62	AR_25329375_ChIP-Seq_VCAP_Human	1.19434142
63	AR_20517297_ChIP-Seq_VCAP_Human	1.18769699
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.18418855
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18022471
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16716863
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.15981925
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15589522
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13884465
70	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13587807
71	TCF4_23295773_ChIP-Seq_U87_Human	1.13494299
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13017469
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12356852
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11611264
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10971457
76	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.10798385
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.08761254
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08760134
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07651634
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05695931
81	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.05672025
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04780709
83	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04485600
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04322101
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04322101
86	STAT3_23295773_ChIP-Seq_U87_Human	1.04004790
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02699047
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02558908
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02502566
90	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.01723644
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00907850
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00109660
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.99263131
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98166302
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98105957
96	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97884696
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96580660
98	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96063573
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95816857
100	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.95548069

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	4.41300030
2	MP0006292_abnormal_olfactory_placode	3.72343465
3	MP0008877_abnormal_DNA_methylation	3.27853745
4	MP0008789_abnormal_olfactory_epithelium	2.76020479
5	MP0002102_abnormal_ear_morphology	2.71898183
6	MP0008872_abnormal_physiological_respon	2.60741350
7	MP0005645_abnormal_hypothalamus_physiol	2.43181073
8	MP0003787_abnormal_imprinting	2.32191470
9	MP0002938_white_spotting	2.27114494
10	MP0002653_abnormal_ependyma_morphology	2.25065259
11	MP0004145_abnormal_muscle_electrophysio	2.06363036
12	MP0005394_taste/olfaction_phenotype	1.98190611
13	MP0005499_abnormal_olfactory_system	1.98190611
14	MP0001968_abnormal_touch/_nociception	1.94991121
15	MP0003646_muscle_fatigue	1.92680454
16	MP0004142_abnormal_muscle_tone	1.90100580
17	MP0003136_yellow_coat_color	1.83333065
18	MP0006276_abnormal_autonomic_nervous	1.73002545
19	MP0001485_abnormal_pinna_reflex	1.71676167
20	MP0003880_abnormal_central_pattern	1.71389704
21	MP0002837_dystrophic_cardiac_calcinosis	1.71313616
22	MP0008875_abnormal_xenobiotic_pharmacok	1.70025165
23	MP0006072_abnormal_retinal_apoptosis	1.65580355
24	MP0001486_abnormal_startle_reflex	1.62770672
25	MP0005389_reproductive_system_phenotype	1.59572810
26	MP0008058_abnormal_DNA_repair	1.58810059
27	MP0002160_abnormal_reproductive_system	1.55463380
28	MP0001188_hyperpigmentation	1.53056856
29	MP0002736_abnormal_nociception_after	1.50088842
30	MP0002876_abnormal_thyroid_physiology	1.45306209
31	MP0000778_abnormal_nervous_system	1.44447470
32	MP0004742_abnormal_vestibular_system	1.44392475
33	MP0005423_abnormal_somatic_nervous	1.43300490
34	MP0004885_abnormal_endolymph	1.42032239
35	MP0005551_abnormal_eye_electrophysiolog	1.42004147
36	MP0005253_abnormal_eye_physiology	1.40180386
37	MP0001984_abnormal_olfaction	1.34052156
38	MP0003011_delayed_dark_adaptation	1.33587493
39	MP0009745_abnormal_behavioral_response	1.31400745
40	MP0005084_abnormal_gallbladder_morpholo	1.31067192
41	MP0001293_anophthalmia	1.30844827
42	MP0003567_abnormal_fetal_cardiomyocyte	1.30192525
43	MP0002272_abnormal_nervous_system	1.29941339
44	MP0005671_abnormal_response_to	1.29149580
45	MP0009379_abnormal_foot_pigmentation	1.26893303
46	MP0001919_abnormal_reproductive_system	1.26492412
47	MP0000230_abnormal_systemic_arterial	1.25672275
48	MP0001529_abnormal_vocalization	1.24529561
49	MP0003718_maternal_effect	1.24529518
50	MP0003121_genomic_imprinting	1.24474880
51	MP0005167_abnormal_blood-brain_barrier	1.23342212
52	MP0005379_endocrine/exocrine_gland_phen	1.21765085
53	MP0001764_abnormal_homeostasis	1.21750769
54	MP0000631_abnormal_neuroendocrine_gland	1.19778611
55	MP0003195_calcinosis	1.17650420
56	MP0003045_fibrosis	1.16856350
57	MP0004215_abnormal_myocardial_fiber	1.15950888
58	MP0001501_abnormal_sleep_pattern	1.15227064
59	MP0001986_abnormal_taste_sensitivity	1.14939177
60	MP0002184_abnormal_innervation	1.13776087
61	MP0001905_abnormal_dopamine_level	1.11324525
62	MP0002735_abnormal_chemical_nociception	1.07790282
63	MP0005410_abnormal_fertilization	1.07345347
64	MP0002909_abnormal_adrenal_gland	1.06776133
65	MP0003693_abnormal_embryo_hatching	1.05746848
66	MP0005646_abnormal_pituitary_gland	1.04877664
67	MP0002751_abnormal_autonomic_nervous	1.04230266
68	MP0003938_abnormal_ear_development	1.04166810
69	MP0000049_abnormal_middle_ear	1.03093186
70	MP0000566_synostosis	1.01578193
71	MP0000647_abnormal_sebaceous_gland	1.01236738
72	MP0001970_abnormal_pain_threshold	0.98479258
73	MP0002557_abnormal_social/conspecific_i	0.97532092
74	MP0002733_abnormal_thermal_nociception	0.91184773
75	MP0002095_abnormal_skin_pigmentation	0.90199452
76	MP0003122_maternal_imprinting	0.88841668
77	MP0002210_abnormal_sex_determination	0.87685902
78	MP0004133_heterotaxia	0.87086047
79	MP0005195_abnormal_posterior_eye	0.85962135
80	MP0002163_abnormal_gland_morphology	0.85944279
81	MP0002138_abnormal_hepatobiliary_system	0.85914495
82	MP0000026_abnormal_inner_ear	0.84445803
83	MP0002234_abnormal_pharynx_morphology	0.82710908
84	MP0003123_paternal_imprinting	0.81992643
85	MP0001119_abnormal_female_reproductive	0.79403925
86	MP0000579_abnormal_nail_morphology	0.79394757
87	MP0002638_abnormal_pupillary_reflex	0.78041135
88	MP0002572_abnormal_emotion/affect_behav	0.77328005
89	MP0002067_abnormal_sensory_capabilities	0.76332657
90	MP0002752_abnormal_somatic_nervous	0.75017228
91	MP0001502_abnormal_circadian_rhythm	0.73701037
92	MP0008995_early_reproductive_senescence	0.72958493
93	MP0002396_abnormal_hematopoietic_system	0.72532287
94	MP0001929_abnormal_gametogenesis	0.72417688
95	MP0000955_abnormal_spinal_cord	0.71568870
96	MP0005391_vision/eye_phenotype	0.70881854
97	MP0005670_abnormal_white_adipose	0.70852502
98	MP0000653_abnormal_sex_gland	0.70650551
99	MP0005171_absent_coat_pigmentation	0.69828469
100	MP0005647_abnormal_sex_gland	0.69016682

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.82989083
2	Colon cancer (HP:0003003)	4.12894166
3	Pancreatic fibrosis (HP:0100732)	3.39985626
4	Cystic liver disease (HP:0006706)	3.16567921
5	True hermaphroditism (HP:0010459)	3.14958961
6	Reticulocytopenia (HP:0001896)	3.07662180
7	Chromsome breakage (HP:0040012)	2.96153414
8	Supernumerary spleens (HP:0009799)	2.94262922
9	Pancreatic cysts (HP:0001737)	2.93762333
10	Abnormality of the renal cortex (HP:0011035)	2.93401516
11	Pendular nystagmus (HP:0012043)	2.91699570
12	Abnormality of midbrain morphology (HP:0002418)	2.83363888
13	Molar tooth sign on MRI (HP:0002419)	2.83363888
14	Abnormality of DNA repair (HP:0003254)	2.81276976
15	Medial flaring of the eyebrow (HP:0010747)	2.79362183
16	Abolished electroretinogram (ERG) (HP:0000550)	2.73964559
17	Focal motor seizures (HP:0011153)	2.70925092
18	Prostate neoplasm (HP:0100787)	2.57263605
19	Renal cortical cysts (HP:0000803)	2.56584610
20	Methylmalonic acidemia (HP:0002912)	2.52269603
21	Tubular atrophy (HP:0000092)	2.51450764
22	Congenital stationary night blindness (HP:0007642)	2.51432345
23	Calf muscle hypertrophy (HP:0008981)	2.51035885
24	Type 2 muscle fiber atrophy (HP:0003554)	2.50467733
25	Keratoconus (HP:0000563)	2.49442917
26	Increased corneal curvature (HP:0100692)	2.49442917
27	Nephronophthisis (HP:0000090)	2.45429088
28	Gastrointestinal atresia (HP:0002589)	2.45334772
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.42060865
30	Sclerocornea (HP:0000647)	2.39921497
31	Esophageal atresia (HP:0002032)	2.38838116
32	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.38221463
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.37817664
34	Absent/shortened dynein arms (HP:0200106)	2.37817664
35	Hepatocellular necrosis (HP:0001404)	2.34084670
36	Bony spicule pigmentary retinopathy (HP:0007737)	2.33235583
37	Acute necrotizing encephalopathy (HP:0006965)	2.26029907
38	Abnormality of the renal collecting system (HP:0004742)	2.25009240
39	Tubulointerstitial nephritis (HP:0001970)	2.24955391
40	Muscle hypertrophy of the lower extremities (HP:0008968)	2.20626637
41	Optic nerve hypoplasia (HP:0000609)	2.20164680
42	Birth length less than 3rd percentile (HP:0003561)	2.20085457
43	Progressive cerebellar ataxia (HP:0002073)	2.20040864
44	Abnormality of the renal medulla (HP:0100957)	2.19363775
45	Methylmalonic aciduria (HP:0012120)	2.17775437
46	Oligodactyly (HP:0012165)	2.17418756
47	Duplicated collecting system (HP:0000081)	2.17413359
48	Hypoproteinemia (HP:0003075)	2.17379850
49	Constricted visual fields (HP:0001133)	2.15733295
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.15439779
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14447339
52	Stomach cancer (HP:0012126)	2.12084953
53	Small hand (HP:0200055)	2.11166591
54	Gait imbalance (HP:0002141)	2.10802250
55	Oligodactyly (hands) (HP:0001180)	2.10143240
56	Congenital primary aphakia (HP:0007707)	2.09603781
57	Hepatic necrosis (HP:0002605)	2.07453956
58	Abnormal rod and cone electroretinograms (HP:0008323)	2.06573955
59	Hyperglycinemia (HP:0002154)	2.05407322
60	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.04669293
61	Absent thumb (HP:0009777)	2.04643512
62	Patellar aplasia (HP:0006443)	2.04583504
63	Abnormal drinking behavior (HP:0030082)	2.03978661
64	Polydipsia (HP:0001959)	2.03978661
65	Postaxial foot polydactyly (HP:0001830)	2.02017981
66	Abnormal mitochondria in muscle tissue (HP:0008316)	2.02014644
67	Abnormality of cochlea (HP:0000375)	2.00491276
68	Triphalangeal thumb (HP:0001199)	2.00359269
69	Hypochromic microcytic anemia (HP:0004840)	2.00015052
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99561290
71	Mitochondrial inheritance (HP:0001427)	1.98728990
72	Hypoplasia of the thymus (HP:0000778)	1.96962761
73	Progressive macrocephaly (HP:0004481)	1.96504947
74	Abnormality of the pons (HP:0007361)	1.95762370
75	Anencephaly (HP:0002323)	1.95132587
76	Acute encephalopathy (HP:0006846)	1.94133160
77	Tubulointerstitial abnormality (HP:0001969)	1.93788306
78	Attenuation of retinal blood vessels (HP:0007843)	1.93696374
79	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93588527
80	Abnormal protein N-linked glycosylation (HP:0012347)	1.93588527
81	Abnormal protein glycosylation (HP:0012346)	1.93588527
82	Abnormal glycosylation (HP:0012345)	1.93588527
83	Aplasia/Hypoplasia of the patella (HP:0006498)	1.92439942
84	Nephrogenic diabetes insipidus (HP:0009806)	1.92323137
85	Severe muscular hypotonia (HP:0006829)	1.91854876
86	Congenital, generalized hypertrichosis (HP:0004540)	1.90685560
87	Chronic hepatic failure (HP:0100626)	1.90313532
88	Confusion (HP:0001289)	1.89432510
89	Meckel diverticulum (HP:0002245)	1.89422283
90	Increased CSF lactate (HP:0002490)	1.88382588
91	Chorioretinal atrophy (HP:0000533)	1.87202557
92	Short tibia (HP:0005736)	1.86525222
93	Inability to walk (HP:0002540)	1.86209996
94	Morphological abnormality of the inner ear (HP:0011390)	1.85931943
95	Abnormality of the ileum (HP:0001549)	1.85493385
96	Thyroiditis (HP:0100646)	1.84708126
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84462986
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.84064450
99	Focal seizures (HP:0007359)	1.83761036
100	Intestinal atresia (HP:0011100)	1.83727917

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.29311955
2	FRK	3.39765948
3	NUAK1	2.82035242
4	STK16	2.54783250
5	WNK4	2.51209437
6	ADRBK2	2.40315630
7	TAOK3	2.37432922
8	ZAK	2.36551255
9	EIF2AK3	2.35000204
10	PNCK	2.28907305
11	WEE1	2.21487492
12	WNK3	2.14978259
13	STK39	2.09403337
14	CAMKK2	2.01235931
15	MAPKAPK5	1.88550784
16	OXSR1	1.80695296
17	MAPK13	1.76155804
18	BRSK2	1.73957010
19	PINK1	1.66025489
20	TLK1	1.65214194
21	GRK1	1.61954034
22	CDC7	1.35404536
23	VRK2	1.31173013
24	FLT3	1.24093729
25	TAF1	1.23809475
26	DYRK2	1.20285378
27	PLK4	1.19475043
28	PAK3	1.13780690
29	MUSK	1.10094356
30	EIF2AK2	1.09706987
31	DMPK	1.05250761
32	GRK7	1.00405385
33	VRK1	0.99874811
34	TXK	0.98655224
35	CCNB1	0.96110929
36	PAK6	0.95374917
37	MKNK2	0.94666343
38	PLK3	0.93658673
39	MAP3K4	0.92887466
40	STK38L	0.90540779
41	CAMKK1	0.89847820
42	NTRK2	0.88504381
43	PRKCG	0.85145252
44	ACVR1B	0.84367807
45	TRIM28	0.82304570
46	MAPK15	0.79243296
47	BMPR1B	0.76841971
48	CDK3	0.76567128
49	BRSK1	0.74831758
50	EPHB2	0.72650583
51	EPHA4	0.71676902
52	CASK	0.71472924
53	EIF2AK1	0.70293114
54	KIT	0.70019078
55	KDR	0.69388993
56	MAP2K2	0.68926843
57	MAP2K7	0.68776955
58	ADRBK1	0.66528571
59	PLK1	0.66308889
60	IKBKE	0.65368164
61	CSNK1G1	0.62165175
62	GRK5	0.61057246
63	SGK2	0.60067589
64	PRKD3	0.58518153
65	CSF1R	0.55126939
66	INSRR	0.54580590
67	MINK1	0.52662359
68	CAMK1	0.52547348
69	CSNK1G3	0.52296877
70	PRKACA	0.52204032
71	CAMK2A	0.52042454
72	MKNK1	0.50833309
73	RAF1	0.50358625
74	PRKCE	0.49703431
75	IKBKB	0.49412619
76	NME1	0.49330325
77	ATM	0.46678774
78	CSNK1A1L	0.46610024
79	CSNK1D	0.45282033
80	CSNK1G2	0.44630186
81	BCKDK	0.43320924
82	PTK2B	0.42592085
83	PKN1	0.42076486
84	ATR	0.40553957
85	AURKB	0.40512880
86	CSNK1A1	0.40158700
87	BCR	0.39918345
88	PRKDC	0.39890102
89	SRPK1	0.39624001
90	CLK1	0.38450442
91	RPS6KA5	0.38060337
92	CDK19	0.37138714
93	PRKCA	0.35500921
94	TEC	0.35451425
95	CSNK2A1	0.35387247
96	PRKAA2	0.33919319
97	PBK	0.33755767
98	PDK2	0.32482868
99	TIE1	0.32431188
100	MST4	0.32368652

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.39756900
2	Homologous recombination_Homo sapiens_hsa03440	2.66496026
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.60526809
4	Mismatch repair_Homo sapiens_hsa03430	2.50399394
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44623475
6	Caffeine metabolism_Homo sapiens_hsa00232	2.30785000
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.24274484
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20755817
9	Propanoate metabolism_Homo sapiens_hsa00640	2.16865007
10	Parkinsons disease_Homo sapiens_hsa05012	2.15033424
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08232294
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.93151717
13	Proteasome_Homo sapiens_hsa03050	1.84072398
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78858499
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.75066641
16	Phototransduction_Homo sapiens_hsa04744	1.71152233
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.70882167
18	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.69060528
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.66461566
20	Ribosome_Homo sapiens_hsa03010	1.63393664
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62325731
22	Asthma_Homo sapiens_hsa05310	1.56151870
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.44798657
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.43643988
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.42346620
26	Huntingtons disease_Homo sapiens_hsa05016	1.39100154
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38052799
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37675302
29	RNA polymerase_Homo sapiens_hsa03020	1.37641245
30	Butanoate metabolism_Homo sapiens_hsa00650	1.37258363
31	Sulfur metabolism_Homo sapiens_hsa00920	1.32195008
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31260979
33	Alzheimers disease_Homo sapiens_hsa05010	1.29903403
34	Basal transcription factors_Homo sapiens_hsa03022	1.26593042
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.23030792
36	RNA degradation_Homo sapiens_hsa03018	1.19885731
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.19761414
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.19470029
39	Nicotine addiction_Homo sapiens_hsa05033	1.17941784
40	Histidine metabolism_Homo sapiens_hsa00340	1.16696409
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.14724823
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.13923519
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13312183
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12136846
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08423006
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.08122432
47	Retinol metabolism_Homo sapiens_hsa00830	1.06879892
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06721894
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04858028
50	One carbon pool by folate_Homo sapiens_hsa00670	1.04454200
51	Glycerolipid metabolism_Homo sapiens_hsa00561	1.00254225
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99227885
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96256455
54	Peroxisome_Homo sapiens_hsa04146	0.96112922
55	Olfactory transduction_Homo sapiens_hsa04740	0.93501429
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88216798
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86298452
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83236164
59	RNA transport_Homo sapiens_hsa03013	0.80774681
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.79293899
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78663738
62	Taste transduction_Homo sapiens_hsa04742	0.77296189
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76981315
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74237171
65	Purine metabolism_Homo sapiens_hsa00230	0.73977692
66	Morphine addiction_Homo sapiens_hsa05032	0.73805120
67	Fatty acid degradation_Homo sapiens_hsa00071	0.70682772
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.70111748
69	Regulation of autophagy_Homo sapiens_hsa04140	0.69073177
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.68003065
71	Allograft rejection_Homo sapiens_hsa05330	0.65900321
72	Folate biosynthesis_Homo sapiens_hsa00790	0.65201606
73	DNA replication_Homo sapiens_hsa03030	0.65074590
74	Serotonergic synapse_Homo sapiens_hsa04726	0.64810082
75	ABC transporters_Homo sapiens_hsa02010	0.64789141
76	Base excision repair_Homo sapiens_hsa03410	0.62445745
77	Salivary secretion_Homo sapiens_hsa04970	0.62275699
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60843942
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.60573197
80	Circadian entrainment_Homo sapiens_hsa04713	0.58109937
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56946431
82	Metabolic pathways_Homo sapiens_hsa01100	0.53832653
83	p53 signaling pathway_Homo sapiens_hsa04115	0.53036162
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.50444799
85	Spliceosome_Homo sapiens_hsa03040	0.49770436
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48176007
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47516285
88	Graft-versus-host disease_Homo sapiens_hsa05332	0.47368030
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45542440
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44523886
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42370523
92	GABAergic synapse_Homo sapiens_hsa04727	0.40341663
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.39811332
94	Sulfur relay system_Homo sapiens_hsa04122	0.38813889
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34527110
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.33774633
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33133900
98	Renin secretion_Homo sapiens_hsa04924	0.31188558
99	Long-term depression_Homo sapiens_hsa04730	0.30327507
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30278186

RPS3AP33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »