RPS3AP34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore assembly (GO:0051382)4.46886827
2endoderm formation (GO:0001706)4.22917138
3protein neddylation (GO:0045116)4.13102865
4chromatin remodeling at centromere (GO:0031055)4.10824429
5replication fork processing (GO:0031297)4.06045818
6regulation of mesoderm development (GO:2000380)4.05872704
7kinetochore organization (GO:0051383)4.01528667
8CENP-A containing nucleosome assembly (GO:0034080)3.95318609
9regulation of mitotic spindle checkpoint (GO:1903504)3.94837208
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.94837208
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.91470283
12somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.82216979
13isotype switching (GO:0045190)3.82216979
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.82216979
15axonemal dynein complex assembly (GO:0070286)3.76214787
16DNA double-strand break processing (GO:0000729)3.73795389
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70461218
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.68119974
19histone exchange (GO:0043486)3.57573843
20anterior/posterior axis specification, embryo (GO:0008595)3.54927452
21intraciliary transport (GO:0042073)3.49862641
22DNA replication-dependent nucleosome organization (GO:0034723)3.40473303
23DNA replication-dependent nucleosome assembly (GO:0006335)3.40473303
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.37784422
25centriole replication (GO:0007099)3.35028122
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33414523
27cilium movement (GO:0003341)3.28221643
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27978028
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27978028
30somite rostral/caudal axis specification (GO:0032525)3.27015706
31cilium or flagellum-dependent cell motility (GO:0001539)3.24280517
32epithelial cilium movement (GO:0003351)3.23298716
33otic vesicle formation (GO:0030916)3.22355609
34regulation of cilium movement (GO:0003352)3.20496522
35cullin deneddylation (GO:0010388)3.15598407
36negative regulation of activin receptor signaling pathway (GO:0032926)3.14447187
37regulation of centriole replication (GO:0046599)3.12194297
38recombinational repair (GO:0000725)3.11741375
39double-strand break repair via homologous recombination (GO:0000724)3.11716275
40protein deneddylation (GO:0000338)3.07577259
41platelet dense granule organization (GO:0060155)3.05474485
42kidney morphogenesis (GO:0060993)3.00774691
43reciprocal meiotic recombination (GO:0007131)2.98755009
44reciprocal DNA recombination (GO:0035825)2.98755009
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95443341
46axoneme assembly (GO:0035082)2.94864301
47DNA replication checkpoint (GO:0000076)2.94094170
48proteasome assembly (GO:0043248)2.93424929
49DNA replication-independent nucleosome assembly (GO:0006336)2.91703725
50DNA replication-independent nucleosome organization (GO:0034724)2.91703725
51primitive streak formation (GO:0090009)2.90343945
52regulation of telomere maintenance via telomerase (GO:0032210)2.90281070
53DNA deamination (GO:0045006)2.89775338
54somatic recombination of immunoglobulin gene segments (GO:0016447)2.88970443
55water-soluble vitamin biosynthetic process (GO:0042364)2.88913502
56detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88796053
57chaperone-mediated protein transport (GO:0072321)2.83032519
58peptidyl-histidine modification (GO:0018202)2.82493834
59postreplication repair (GO:0006301)2.82402913
60histone mRNA metabolic process (GO:0008334)2.82083479
61base-excision repair, AP site formation (GO:0006285)2.79929520
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78794995
63branched-chain amino acid catabolic process (GO:0009083)2.77885333
64mitotic G2/M transition checkpoint (GO:0044818)2.74026482
65negative regulation of DNA recombination (GO:0045910)2.71495699
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.71319917
67somatic diversification of immunoglobulins (GO:0016445)2.70775092
68lysine metabolic process (GO:0006553)2.69579456
69lysine catabolic process (GO:0006554)2.69579456
70embryonic axis specification (GO:0000578)2.68578821
71L-fucose catabolic process (GO:0042355)2.66750176
72fucose catabolic process (GO:0019317)2.66750176
73L-fucose metabolic process (GO:0042354)2.66750176
74glyoxylate metabolic process (GO:0046487)2.66371942
75cilium organization (GO:0044782)2.66265295
76cell migration involved in gastrulation (GO:0042074)2.65019532
77resolution of meiotic recombination intermediates (GO:0000712)2.64225108
78nephron tubule morphogenesis (GO:0072078)2.63679521
79nephron epithelium morphogenesis (GO:0072088)2.63679521
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.63442653
81regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61445226
82negative regulation of telomere maintenance (GO:0032205)2.61059508
83positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.60793739
84pericardium development (GO:0060039)2.60421139
85respiratory chain complex IV assembly (GO:0008535)2.59741167
86female gonad development (GO:0008585)2.58371253
87cilium morphogenesis (GO:0060271)2.57465990
88embryonic pattern specification (GO:0009880)2.57249522
89DNA ligation (GO:0006266)2.55827807
90cilium assembly (GO:0042384)2.55447853
91DNA strand renaturation (GO:0000733)2.55247431
92synapsis (GO:0007129)2.54528127
93pyrimidine nucleotide catabolic process (GO:0006244)2.54461375
94centrosome organization (GO:0051297)2.54267477
95anterior/posterior axis specification (GO:0009948)2.54146150
96nucleobase biosynthetic process (GO:0046112)2.54004396
97ncRNA catabolic process (GO:0034661)2.53819159
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.53372423
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53372423
100purine nucleobase biosynthetic process (GO:0009113)2.53006182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.06801677
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17068325
3ZNF274_21170338_ChIP-Seq_K562_Hela2.96113788
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95951885
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.90974073
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.86072729
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.67863043
8VDR_22108803_ChIP-Seq_LS180_Human2.53538252
9GBX2_23144817_ChIP-Seq_PC3_Human2.50802915
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42318965
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38632964
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34436918
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32832899
14E2F7_22180533_ChIP-Seq_HELA_Human2.30949964
15EWS_26573619_Chip-Seq_HEK293_Human2.26582555
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17191558
17FUS_26573619_Chip-Seq_HEK293_Human2.16995084
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.10119921
19P300_19829295_ChIP-Seq_ESCs_Human2.09596546
20ELK1_19687146_ChIP-ChIP_HELA_Human2.02634862
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99983072
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92154763
23TAF15_26573619_Chip-Seq_HEK293_Human1.84366581
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82693777
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81587219
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75991520
27VDR_23849224_ChIP-Seq_CD4+_Human1.71719535
28IGF1R_20145208_ChIP-Seq_DFB_Human1.69635822
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68843739
30MYC_18940864_ChIP-ChIP_HL60_Human1.68702188
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68591466
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68432495
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64744708
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60040183
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59519917
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.57151560
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54492297
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52611014
39BCAT_22108803_ChIP-Seq_LS180_Human1.49784812
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47631795
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.47138564
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46725824
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.45628131
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.45206261
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44940243
46IRF1_19129219_ChIP-ChIP_H3396_Human1.42499197
47FOXP3_21729870_ChIP-Seq_TREG_Human1.40815198
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40001844
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38966108
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38700038
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.36979397
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35639833
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35098733
54TCF4_22108803_ChIP-Seq_LS180_Human1.34224742
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33643262
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.33283655
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29707692
58SMAD3_21741376_ChIP-Seq_HESCs_Human1.28801606
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28450509
60TP53_22573176_ChIP-Seq_HFKS_Human1.27466431
61NANOG_19829295_ChIP-Seq_ESCs_Human1.23908459
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23908459
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21353295
64ER_23166858_ChIP-Seq_MCF-7_Human1.19336951
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.18336732
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17209059
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14422680
68CBP_20019798_ChIP-Seq_JUKART_Human1.14422680
69SMAD4_21799915_ChIP-Seq_A2780_Human1.14283429
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12768186
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.12372786
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11289955
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.10505672
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.10213147
75SMAD4_21741376_ChIP-Seq_HESCs_Human1.05151569
76EZH2_22144423_ChIP-Seq_EOC_Human1.04962889
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04508691
78RUNX2_22187159_ChIP-Seq_PCA_Human1.04035256
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03490320
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.02782072
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02264687
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01165070
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00446188
84STAT3_23295773_ChIP-Seq_U87_Human0.99379283
85ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98568544
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98483868
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.97527460
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97462825
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97462825
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97138416
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96969975
92GABP_19822575_ChIP-Seq_HepG2_Human0.95925885
93P53_22387025_ChIP-Seq_ESCs_Mouse0.95888268
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.95604657
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95604657
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.95356224
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95323162
98TCF4_23295773_ChIP-Seq_U87_Human0.94880697
99EOMES_21245162_ChIP-Seq_HESCs_Human0.94780840
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94315428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry5.18354773
2MP0006292_abnormal_olfactory_placode4.60179225
3MP0003136_yellow_coat_color2.72141734
4MP0010094_abnormal_chromosome_stability2.52022090
5MP0001293_anophthalmia2.41375527
6MP0003119_abnormal_digestive_system2.38268199
7MP0005075_abnormal_melanosome_morpholog2.37068187
8MP0004133_heterotaxia2.36385886
9MP0006072_abnormal_retinal_apoptosis2.23669156
10MP0000372_irregular_coat_pigmentation2.21016137
11MP0008877_abnormal_DNA_methylation2.16937385
12MP0001529_abnormal_vocalization2.12934680
13MP0003195_calcinosis2.01915026
14MP0008058_abnormal_DNA_repair1.99927398
15MP0002736_abnormal_nociception_after1.99256773
16MP0002102_abnormal_ear_morphology1.98586021
17MP0005499_abnormal_olfactory_system1.97648670
18MP0005394_taste/olfaction_phenotype1.97648670
19MP0002938_white_spotting1.96370296
20MP0001984_abnormal_olfaction1.91779801
21MP0005174_abnormal_tail_pigmentation1.86556866
22MP0003567_abnormal_fetal_cardiomyocyte1.85387215
23MP0003937_abnormal_limbs/digits/tail_de1.81627846
24MP0002233_abnormal_nose_morphology1.78822689
25MP0006054_spinal_hemorrhage1.76643582
26MP0008789_abnormal_olfactory_epithelium1.74274134
27MP0004147_increased_porphyrin_level1.66264654
28MP0003787_abnormal_imprinting1.65186025
29MP0005551_abnormal_eye_electrophysiolog1.60867925
30MP0003941_abnormal_skin_development1.57872782
31MP0004264_abnormal_extraembryonic_tissu1.53855048
32MP0002277_abnormal_respiratory_mucosa1.52110122
33MP0008872_abnormal_physiological_respon1.50391847
34MP0002095_abnormal_skin_pigmentation1.46534213
35MP0002837_dystrophic_cardiac_calcinosis1.40812292
36MP0001968_abnormal_touch/_nociception1.37924191
37MP0008932_abnormal_embryonic_tissue1.35073564
38MP0003880_abnormal_central_pattern1.30160097
39MP0003122_maternal_imprinting1.29535852
40MP0003718_maternal_effect1.26132729
41MP0005084_abnormal_gallbladder_morpholo1.25014818
42MP0005253_abnormal_eye_physiology1.23303111
43MP0003121_genomic_imprinting1.22766033
44MP0000049_abnormal_middle_ear1.22641864
45MP0001286_abnormal_eye_development1.21693134
46MP0010030_abnormal_orbit_morphology1.21215628
47MP0001188_hyperpigmentation1.20419697
48MP0002234_abnormal_pharynx_morphology1.20296489
49MP0003693_abnormal_embryo_hatching1.17122484
50MP0003111_abnormal_nucleus_morphology1.14301738
51MP0004957_abnormal_blastocyst_morpholog1.08288412
52MP0008995_early_reproductive_senescence1.07745465
53MP0002638_abnormal_pupillary_reflex1.06987561
54MP0003186_abnormal_redox_activity1.06711762
55MP0002111_abnormal_tail_morphology1.06503933
56MP0002084_abnormal_developmental_patter1.04199929
57MP0002090_abnormal_vision1.03722876
58MP0001986_abnormal_taste_sensitivity1.02428257
59MP0000631_abnormal_neuroendocrine_gland1.00416233
60MP0003077_abnormal_cell_cycle0.97318333
61MP0003137_abnormal_impulse_conducting0.96537721
62MP0004145_abnormal_muscle_electrophysio0.96435172
63MP0001485_abnormal_pinna_reflex0.96080585
64MP0002160_abnormal_reproductive_system0.93006301
65MP0003385_abnormal_body_wall0.92962964
66MP0004142_abnormal_muscle_tone0.92525862
67MP0005195_abnormal_posterior_eye0.92296472
68MP0004215_abnormal_myocardial_fiber0.92076685
69MP0009697_abnormal_copulation0.91984472
70MP0001929_abnormal_gametogenesis0.91602374
71MP0002751_abnormal_autonomic_nervous0.90555154
72MP0003938_abnormal_ear_development0.90528717
73MP0002210_abnormal_sex_determination0.88945589
74MP0001486_abnormal_startle_reflex0.88010046
75MP0000427_abnormal_hair_cycle0.87582927
76MP0005391_vision/eye_phenotype0.87100251
77MP0005367_renal/urinary_system_phenotyp0.86995182
78MP0000516_abnormal_urinary_system0.86995182
79MP0005380_embryogenesis_phenotype0.86951354
80MP0001672_abnormal_embryogenesis/_devel0.86951354
81MP0000015_abnormal_ear_pigmentation0.86505783
82MP0001324_abnormal_eye_pigmentation0.85374831
83MP0005248_abnormal_Harderian_gland0.82174935
84MP0004885_abnormal_endolymph0.81824495
85MP0000371_diluted_coat_color0.80643533
86MP0008004_abnormal_stomach_pH0.80466908
87MP0000428_abnormal_craniofacial_morphol0.80161997
88MP0002752_abnormal_somatic_nervous0.79758172
89MP0003646_muscle_fatigue0.78114262
90MP0000653_abnormal_sex_gland0.77421560
91MP0002109_abnormal_limb_morphology0.77320186
92MP0001119_abnormal_female_reproductive0.76912810
93MP0001963_abnormal_hearing_physiology0.76633730
94MP0000569_abnormal_digit_pigmentation0.74709365
95MP0002282_abnormal_trachea_morphology0.73384172
96MP0003698_abnormal_male_reproductive0.73042763
97MP0000647_abnormal_sebaceous_gland0.72356394
98MP0001145_abnormal_male_reproductive0.71783028
99MP0002557_abnormal_social/conspecific_i0.71095558
100MP0000026_abnormal_inner_ear0.70913276

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.88573324
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44487328
3Colon cancer (HP:0003003)3.42745228
4Pancreatic fibrosis (HP:0100732)3.38713128
5Molar tooth sign on MRI (HP:0002419)3.35433861
6Abnormality of midbrain morphology (HP:0002418)3.35433861
7Pancreatic cysts (HP:0001737)3.34444516
8Abnormal respiratory motile cilium physiology (HP:0012261)3.27295248
9Absent/shortened dynein arms (HP:0200106)3.24547178
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.24547178
11Abnormal respiratory motile cilium morphology (HP:0005938)3.22921186
12Abnormal respiratory epithelium morphology (HP:0012253)3.22921186
13Abnormal ciliary motility (HP:0012262)3.15103348
14True hermaphroditism (HP:0010459)3.03121503
15Volvulus (HP:0002580)2.89687359
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.85814770
17Nephronophthisis (HP:0000090)2.82092987
18Chronic hepatic failure (HP:0100626)2.78236860
19Abnormality of the ileum (HP:0001549)2.74923694
20Medial flaring of the eyebrow (HP:0010747)2.74745706
21Meckel diverticulum (HP:0002245)2.69743124
22Bifid tongue (HP:0010297)2.66112690
23Rhinitis (HP:0012384)2.64002900
24Abnormality of chromosome stability (HP:0003220)2.62931534
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.62779555
26Abnormality of the labia minora (HP:0012880)2.57906015
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54721856
28Abolished electroretinogram (ERG) (HP:0000550)2.52355146
29Intestinal atresia (HP:0011100)2.50853790
30Chromsome breakage (HP:0040012)2.49323426
31Hyperglycinemia (HP:0002154)2.47018848
32Genital tract atresia (HP:0001827)2.44931658
33Optic nerve hypoplasia (HP:0000609)2.44421008
34Progressive inability to walk (HP:0002505)2.43381463
35Vaginal atresia (HP:0000148)2.42688926
36Supernumerary spleens (HP:0009799)2.41400500
37Congenital primary aphakia (HP:0007707)2.37232928
38Abnormality of the renal medulla (HP:0100957)2.35832319
39Anencephaly (HP:0002323)2.30126803
40Gait imbalance (HP:0002141)2.29586968
41Bile duct proliferation (HP:0001408)2.24621881
42Abnormal biliary tract physiology (HP:0012439)2.24621881
43Asplenia (HP:0001746)2.22639187
44Triphalangeal thumb (HP:0001199)2.22315030
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21591839
46Abnormality of alanine metabolism (HP:0010916)2.21591839
47Hyperalaninemia (HP:0003348)2.21591839
48Postaxial foot polydactyly (HP:0001830)2.19579368
49Absent septum pellucidum (HP:0001331)2.18352381
50Absent radius (HP:0003974)2.15382412
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.14441852
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.13838197
53Abnormality of the preputium (HP:0100587)2.13422370
54Nephrogenic diabetes insipidus (HP:0009806)2.11865108
55Reticulocytopenia (HP:0001896)2.11456975
56Abnormal lung lobation (HP:0002101)2.11072836
57Chronic bronchitis (HP:0004469)2.10944927
58Cystic liver disease (HP:0006706)2.08790268
59Methylmalonic acidemia (HP:0002912)2.06006554
60Absent forearm bone (HP:0003953)2.04545045
61Aplasia involving forearm bones (HP:0009822)2.04545045
62Abnormality of serum amino acid levels (HP:0003112)2.04399169
63Clubbing of toes (HP:0100760)2.03989436
64Double outlet right ventricle (HP:0001719)2.02770568
65Congenital malformation of the right heart (HP:0011723)2.02770568
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02622420
67Abnormal hair whorl (HP:0010721)2.01766348
68Enlarged kidneys (HP:0000105)2.01117577
69Sloping forehead (HP:0000340)1.99661369
70Preaxial hand polydactyly (HP:0001177)1.99609017
71Congenital hepatic fibrosis (HP:0002612)1.99318030
72Abnormality of the renal cortex (HP:0011035)1.99119192
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.98882552
74Anophthalmia (HP:0000528)1.96446424
75Hyperglycinuria (HP:0003108)1.96245986
76Sclerocornea (HP:0000647)1.93079146
77Growth hormone deficiency (HP:0000824)1.90336798
78Inability to walk (HP:0002540)1.87993673
79Oligodactyly (hands) (HP:0001180)1.84617248
80Abnormal pancreas size (HP:0012094)1.83005748
81Duodenal stenosis (HP:0100867)1.81588010
82Small intestinal stenosis (HP:0012848)1.81588010
83Abnormality of the parathyroid morphology (HP:0011766)1.81318912
84Maternal diabetes (HP:0009800)1.80527667
85Abnormality of glycine metabolism (HP:0010895)1.80523126
86Abnormality of serine family amino acid metabolism (HP:0010894)1.80523126
87Hypoplastic pelvis (HP:0008839)1.80048103
88Abnormality of the duodenum (HP:0002246)1.80037715
89Abnormality of the septum pellucidum (HP:0007375)1.79145107
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78865572
91Postaxial hand polydactyly (HP:0001162)1.77770009
92Labial hypoplasia (HP:0000066)1.75767094
93Oligohydramnios (HP:0001562)1.75573937
94Disproportionate short-trunk short stature (HP:0003521)1.75211707
95Broad foot (HP:0001769)1.75015178
96Occipital encephalocele (HP:0002085)1.74141858
97Median cleft lip (HP:0000161)1.73817078
98Dandy-Walker malformation (HP:0001305)1.73499073
99Poor coordination (HP:0002370)1.73454562
100Bronchiectasis (HP:0002110)1.71861375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.15907985
2ACVR1B3.57198181
3BMPR1B3.56903947
4MAP4K23.27046995
5PBK3.07307091
6TNIK2.99434521
7WNK32.73699191
8MKNK22.54776565
9PLK42.54452047
10TRIM282.47388018
11FRK2.38976451
12ERBB42.30349952
13ZAK2.29460326
14MST42.22788524
15PDK22.05088556
16NUAK12.01459374
17NME11.95852453
18MKNK11.85853842
19EIF2AK31.78728525
20CDC71.67432373
21GRK11.59354351
22WEE11.53665968
23FLT31.46473374
24SRPK11.44118764
25ADRBK21.41997906
26TGFBR11.35762881
27PLK31.34191737
28NEK11.29548853
29PKN21.26265902
30BCKDK1.20734539
31PINK11.20047809
32TSSK61.19892608
33WNK41.19586129
34STK161.16869327
35BUB11.16368376
36PNCK1.13587372
37TTK1.12501514
38TNK21.07721279
39BCR1.06592240
40INSRR1.03596238
41OBSCN1.00412922
42PLK20.96336659
43CDK190.95929862
44VRK10.95754016
45PLK10.94447954
46ERBB30.93250718
47TIE10.92454908
48NEK20.90225770
49FGFR10.84891415
50NLK0.84056395
51VRK20.80743979
52DYRK20.79729741
53STK30.78455198
54ATR0.76586495
55CDK80.75504634
56MAP3K40.72594739
57BRSK20.71211346
58EIF2AK20.70543993
59CSNK1G10.67671238
60KIT0.64618562
61ADRBK10.64520772
62TEC0.63573096
63OXSR10.63115747
64CHEK20.57954747
65PRKCG0.57643846
66MAPK130.57590468
67LATS10.57532120
68STK38L0.56661371
69NTRK20.56009226
70CASK0.55090535
71ATM0.51422127
72PIK3CA0.50859900
73TXK0.50590191
74STK390.45136545
75AURKB0.41746042
76EPHA40.40446001
77MAP2K70.40003132
78PRKCE0.39924685
79EIF2AK10.39225806
80PRKCQ0.38947486
81MAP2K60.38569651
82CSNK1G20.36052337
83PAK30.33876943
84CSNK1G30.32896140
85CSNK1A10.32097843
86MATK0.31871502
87CHEK10.31441897
88CSNK2A10.31068027
89TLK10.30962398
90STK110.30785801
91PRKDC0.28720436
92MAP2K40.27481046
93MAPK150.27222875
94CSNK2A20.27113857
95MELK0.27031920
96CSNK1A1L0.24518951
97IGF1R0.24298224
98MINK10.23857650
99CSNK1D0.23205643
100CDK30.23132530

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.30847610
2Fanconi anemia pathway_Homo sapiens_hsa034602.57101028
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51296130
4Mismatch repair_Homo sapiens_hsa034302.49380488
5Propanoate metabolism_Homo sapiens_hsa006402.47081759
6Proteasome_Homo sapiens_hsa030502.43750849
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37630422
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22131043
9DNA replication_Homo sapiens_hsa030302.06824484
10Non-homologous end-joining_Homo sapiens_hsa034502.06655600
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06084607
12Protein export_Homo sapiens_hsa030602.03755605
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02979908
14RNA polymerase_Homo sapiens_hsa030202.02170869
15RNA degradation_Homo sapiens_hsa030182.01234081
16Basal transcription factors_Homo sapiens_hsa030222.00584281
17Steroid biosynthesis_Homo sapiens_hsa001001.98425957
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92884504
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82930896
20Butanoate metabolism_Homo sapiens_hsa006501.80272207
21Pyruvate metabolism_Homo sapiens_hsa006201.70831582
22Peroxisome_Homo sapiens_hsa041461.62621311
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.57982331
24Fatty acid degradation_Homo sapiens_hsa000711.53752412
25Oxidative phosphorylation_Homo sapiens_hsa001901.52099832
26Phototransduction_Homo sapiens_hsa047441.49118535
27Nucleotide excision repair_Homo sapiens_hsa034201.43580116
28Ribosome_Homo sapiens_hsa030101.42958267
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39835933
30Parkinsons disease_Homo sapiens_hsa050121.39802119
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39124366
32Base excision repair_Homo sapiens_hsa034101.38060731
33Tryptophan metabolism_Homo sapiens_hsa003801.33667819
34RNA transport_Homo sapiens_hsa030131.32523384
35Huntingtons disease_Homo sapiens_hsa050161.31362581
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30461236
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29037769
38Fatty acid metabolism_Homo sapiens_hsa012121.27641053
39Fatty acid elongation_Homo sapiens_hsa000621.26107795
40One carbon pool by folate_Homo sapiens_hsa006701.18466668
41Spliceosome_Homo sapiens_hsa030401.18135160
42Nitrogen metabolism_Homo sapiens_hsa009101.18053099
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17956993
44Selenocompound metabolism_Homo sapiens_hsa004501.08690064
45Basal cell carcinoma_Homo sapiens_hsa052171.07455852
46beta-Alanine metabolism_Homo sapiens_hsa004101.05629121
47Pyrimidine metabolism_Homo sapiens_hsa002401.03061170
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01980878
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01975604
50Chemical carcinogenesis_Homo sapiens_hsa052040.99472382
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99192188
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98870624
53Caffeine metabolism_Homo sapiens_hsa002320.98870126
54Olfactory transduction_Homo sapiens_hsa047400.96771694
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.96165085
56Purine metabolism_Homo sapiens_hsa002300.94049639
57Retinol metabolism_Homo sapiens_hsa008300.92207281
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91525083
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88484410
60Fat digestion and absorption_Homo sapiens_hsa049750.86140064
61Glutathione metabolism_Homo sapiens_hsa004800.85616778
62Linoleic acid metabolism_Homo sapiens_hsa005910.84604161
63Hedgehog signaling pathway_Homo sapiens_hsa043400.82813519
64Cell cycle_Homo sapiens_hsa041100.79961439
65Metabolic pathways_Homo sapiens_hsa011000.73508672
66Lysine degradation_Homo sapiens_hsa003100.72317151
67Alzheimers disease_Homo sapiens_hsa050100.70657486
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70200852
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66743992
70Glycerolipid metabolism_Homo sapiens_hsa005610.65785135
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65587026
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65539611
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65012103
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.64853111
75Wnt signaling pathway_Homo sapiens_hsa043100.61658472
76Carbon metabolism_Homo sapiens_hsa012000.61645825
77Vitamin digestion and absorption_Homo sapiens_hsa049770.61049369
78TGF-beta signaling pathway_Homo sapiens_hsa043500.61024191
79Cardiac muscle contraction_Homo sapiens_hsa042600.58153219
80Nicotine addiction_Homo sapiens_hsa050330.57304082
81Ether lipid metabolism_Homo sapiens_hsa005650.55055050
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54704422
83Arachidonic acid metabolism_Homo sapiens_hsa005900.53402194
84Hippo signaling pathway_Homo sapiens_hsa043900.52811036
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52081945
86p53 signaling pathway_Homo sapiens_hsa041150.48726905
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48185828
88Biosynthesis of amino acids_Homo sapiens_hsa012300.46698268
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.46364463
90Histidine metabolism_Homo sapiens_hsa003400.46343960
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.40691613
92Arginine and proline metabolism_Homo sapiens_hsa003300.40444641
93Taste transduction_Homo sapiens_hsa047420.40204784
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39730118
95Oocyte meiosis_Homo sapiens_hsa041140.38712330
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37973127
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37275445
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35166597
99mRNA surveillance pathway_Homo sapiens_hsa030150.34313310
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34247803

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