ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	9.64775679
2	chromosome organization involved in meiosis (GO:0070192)	5.83364993
3	male meiosis I (GO:0007141)	5.30888091
4	piRNA metabolic process (GO:0034587)	5.28412362
5	presynaptic membrane assembly (GO:0097105)	5.25549018
6	DNA synthesis involved in DNA repair (GO:0000731)	5.22998810
7	nonmotile primary cilium assembly (GO:0035058)	5.03557127
8	regulation of DNA endoreduplication (GO:0032875)	5.00297516
9	meiotic chromosome segregation (GO:0045132)	4.91937858
10	reciprocal meiotic recombination (GO:0007131)	4.69368239
11	reciprocal DNA recombination (GO:0035825)	4.69368239
12	microtubule depolymerization (GO:0007019)	4.65079296
13	DNA methylation involved in gamete generation (GO:0043046)	4.63446849
14	presynaptic membrane organization (GO:0097090)	4.63178133
15	male meiosis (GO:0007140)	4.62707215
16	righting reflex (GO:0060013)	4.61529110
17	replication fork processing (GO:0031297)	4.54457121
18	meiosis I (GO:0007127)	4.40813155
19	regulation of cilium movement (GO:0003352)	4.19789017
20	resolution of meiotic recombination intermediates (GO:0000712)	4.13111509
21	photoreceptor cell maintenance (GO:0045494)	4.04186279
22	signal peptide processing (GO:0006465)	3.85158585
23	sister chromatid cohesion (GO:0007062)	3.73727400
24	synaptonemal complex assembly (GO:0007130)	3.72112029
25	meiotic nuclear division (GO:0007126)	3.71713058
26	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.71474771
27	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.71474771
28	regulation of centriole replication (GO:0046599)	3.70258114
29	auditory receptor cell stereocilium organization (GO:0060088)	3.61933824
30	lysine catabolic process (GO:0006554)	3.61002757
31	lysine metabolic process (GO:0006553)	3.61002757
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.57965383
33	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.57826943
34	kinetochore organization (GO:0051383)	3.57345906
35	meiotic cell cycle process (GO:1903046)	3.55380525
36	synaptonemal complex organization (GO:0070193)	3.53109880
37	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.51915362
38	microtubule polymerization or depolymerization (GO:0031109)	3.48055661
39	metaphase plate congression (GO:0051310)	3.42854014
40	centriole replication (GO:0007099)	3.39221050
41	startle response (GO:0001964)	3.36970771
42	neurotransmitter-gated ion channel clustering (GO:0072578)	3.32474771
43	histone H2A acetylation (GO:0043968)	3.28774552
44	retinal cone cell development (GO:0046549)	3.26586618
45	intraciliary transport (GO:0042073)	3.22313268
46	DNA double-strand break processing (GO:0000729)	3.21531538
47	regulation of centrosome duplication (GO:0010824)	3.17248370
48	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.15336117
49	regulation of mitotic spindle checkpoint (GO:1903504)	3.15336117
50	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.12725562
51	kinetochore assembly (GO:0051382)	3.11973356
52	mitotic spindle checkpoint (GO:0071174)	3.11226259
53	mitotic sister chromatid cohesion (GO:0007064)	3.08958301
54	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.01285036
55	single strand break repair (GO:0000012)	2.98771668
56	attachment of spindle microtubules to kinetochore (GO:0008608)	2.93624778
57	spindle checkpoint (GO:0031577)	2.93544641
58	female gamete generation (GO:0007292)	2.90474856
59	protein K11-linked deubiquitination (GO:0035871)	2.88446447
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.88258069
61	detection of light stimulus involved in visual perception (GO:0050908)	2.88258069
62	DNA catabolic process, exonucleolytic (GO:0000738)	2.87049597
63	regulation of centrosome cycle (GO:0046605)	2.84109773
64	chromatin remodeling at centromere (GO:0031055)	2.83700661
65	regulation of microtubule-based movement (GO:0060632)	2.83374587
66	protein localization to kinetochore (GO:0034501)	2.82642303
67	mitotic sister chromatid segregation (GO:0000070)	2.76640013
68	telomere maintenance via telomerase (GO:0007004)	2.76415737
69	neuron cell-cell adhesion (GO:0007158)	2.75869406
70	aspartate family amino acid catabolic process (GO:0009068)	2.74861806
71	mitotic metaphase plate congression (GO:0007080)	2.73232031
72	DNA strand renaturation (GO:0000733)	2.72929423
73	ubiquinone biosynthetic process (GO:0006744)	2.72099504
74	histone exchange (GO:0043486)	2.71035014
75	intra-S DNA damage checkpoint (GO:0031573)	2.68570138
76	cilium organization (GO:0044782)	2.67763006
77	inner ear receptor stereocilium organization (GO:0060122)	2.67294677
78	non-recombinational repair (GO:0000726)	2.66828534
79	double-strand break repair via nonhomologous end joining (GO:0006303)	2.66828534
80	sister chromatid segregation (GO:0000819)	2.66236675
81	mitotic spindle assembly checkpoint (GO:0007094)	2.66173256
82	indole-containing compound catabolic process (GO:0042436)	2.65438070
83	indolalkylamine catabolic process (GO:0046218)	2.65438070
84	tryptophan catabolic process (GO:0006569)	2.65438070
85	cilium assembly (GO:0042384)	2.64799603
86	regulation of meiosis I (GO:0060631)	2.63863579
87	negative regulation of DNA recombination (GO:0045910)	2.62837455
88	spindle assembly checkpoint (GO:0071173)	2.62730988
89	DNA topological change (GO:0006265)	2.62614984
90	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.62353478
91	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.62353478
92	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.62353478
93	negative regulation of sister chromatid segregation (GO:0033046)	2.62353478
94	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.62353478
95	reflex (GO:0060004)	2.61040656
96	rRNA catabolic process (GO:0016075)	2.60745812
97	protein localization to cilium (GO:0061512)	2.59334573
98	negative regulation of systemic arterial blood pressure (GO:0003085)	2.59153466
99	mannosylation (GO:0097502)	2.58516766
100	cullin deneddylation (GO:0010388)	2.58336471

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.78026635
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.76504210
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.41791906
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.32638452
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.98079601
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80920240
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67693961
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63312475
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.52880020
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.46995451
11	EWS_26573619_Chip-Seq_HEK293_Human	2.44369641
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41540947
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40947980
14	FUS_26573619_Chip-Seq_HEK293_Human	2.40894457
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.22830986
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.19085345
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17837114
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.12167948
19	P300_19829295_ChIP-Seq_ESCs_Human	2.10390560
20	IRF1_19129219_ChIP-ChIP_H3396_Human	2.04908644
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.95406450
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.94791624
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93427195
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.89544572
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83815059
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82774410
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.79119403
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.73073545
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64769951
30	TCF4_22108803_ChIP-Seq_LS180_Human	1.61830890
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.61735905
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61223480
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.58942495
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58132290
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57866356
36	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57239780
37	STAT3_23295773_ChIP-Seq_U87_Human	1.54219739
38	TCF4_23295773_ChIP-Seq_U87_Human	1.52417746
39	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.52382569
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.51002924
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50206399
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50126317
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.49756785
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47995955
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47705491
46	EZH2_22144423_ChIP-Seq_EOC_Human	1.46278991
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45986953
48	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.44601675
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44002010
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43015129
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.41464990
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41464990
53	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38560610
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37573337
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.37019210
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.36265265
57	AR_25329375_ChIP-Seq_VCAP_Human	1.35674118
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.34447241
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33642132
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31609837
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31478444
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31338045
63	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.30864315
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30159700
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27381192
66	E2F7_22180533_ChIP-Seq_HELA_Human	1.24340623
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20692471
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19506605
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18839112
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18283086
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18283086
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16436172
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.13728546
74	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.13317165
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.13232323
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12841564
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10308156
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08440071
79	JUN_21703547_ChIP-Seq_K562_Human	1.07555856
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06210831
81	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.04181707
82	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03633319
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03215774
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01916293
85	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01916293
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01823883
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01372210
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00832729
89	RXR_22108803_ChIP-Seq_LS180_Human	1.00418719
90	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99509027
91	SOX9_26525672_Chip-Seq_HEART_Mouse	0.97946120
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97864467
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97563701
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96677051
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96541634
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96429669
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95621784
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94402759
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.92847846
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92832686

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.76944539
2	MP0008877_abnormal_DNA_methylation	3.73240169
3	MP0003880_abnormal_central_pattern	3.62968653
4	MP0003195_calcinosis	2.41978669
5	MP0001986_abnormal_taste_sensitivity	2.38610544
6	MP0003136_yellow_coat_color	2.35662993
7	MP0005367_renal/urinary_system_phenotyp	2.33670666
8	MP0000516_abnormal_urinary_system	2.33670666
9	MP0003693_abnormal_embryo_hatching	2.26679317
10	MP0004147_increased_porphyrin_level	2.18453495
11	MP0000383_abnormal_hair_follicle	2.12905056
12	MP0002736_abnormal_nociception_after	2.11694447
13	MP0010094_abnormal_chromosome_stability	2.10716302
14	MP0002254_reproductive_system_inflammat	2.08662480
15	MP0005551_abnormal_eye_electrophysiolog	2.04249255
16	MP0001486_abnormal_startle_reflex	2.02811828
17	MP0000427_abnormal_hair_cycle	2.00264281
18	MP0003718_maternal_effect	1.99766331
19	MP0002210_abnormal_sex_determination	1.88691204
20	MP0003646_muscle_fatigue	1.88010031
21	MP0005253_abnormal_eye_physiology	1.77273604
22	MP0001929_abnormal_gametogenesis	1.71735550
23	MP0001984_abnormal_olfaction	1.70870487
24	MP0000579_abnormal_nail_morphology	1.63778719
25	MP0001661_extended_life_span	1.62754674
26	MP0002938_white_spotting	1.61069752
27	MP0001501_abnormal_sleep_pattern	1.60920125
28	MP0003698_abnormal_male_reproductive	1.60001039
29	MP0006072_abnormal_retinal_apoptosis	1.58947877
30	MP0001968_abnormal_touch/_nociception	1.58647632
31	MP0000631_abnormal_neuroendocrine_gland	1.57666185
32	MP0002160_abnormal_reproductive_system	1.57261206
33	MP0000372_irregular_coat_pigmentation	1.53409884
34	MP0008057_abnormal_DNA_replication	1.53059068
35	MP0008995_early_reproductive_senescence	1.52777659
36	MP0010678_abnormal_skin_adnexa	1.50395067
37	MP0003119_abnormal_digestive_system	1.47465622
38	MP0001145_abnormal_male_reproductive	1.47254130
39	MP0000647_abnormal_sebaceous_gland	1.41771902
40	MP0002095_abnormal_skin_pigmentation	1.40843121
41	MP0001188_hyperpigmentation	1.38269104
42	MP0000653_abnormal_sex_gland	1.36480255
43	MP0002102_abnormal_ear_morphology	1.35203363
44	MP0001119_abnormal_female_reproductive	1.34885496
45	MP0006276_abnormal_autonomic_nervous	1.32779594
46	MP0001529_abnormal_vocalization	1.31121993
47	MP0005423_abnormal_somatic_nervous	1.30659797
48	MP0002234_abnormal_pharynx_morphology	1.28938905
49	MP0009046_muscle_twitch	1.23562254
50	MP0005646_abnormal_pituitary_gland	1.23513870
51	MP0004142_abnormal_muscle_tone	1.23108637
52	MP0002653_abnormal_ependyma_morphology	1.20878897
53	MP0002272_abnormal_nervous_system	1.19316359
54	MP0000569_abnormal_digit_pigmentation	1.17937834
55	MP0003111_abnormal_nucleus_morphology	1.17746089
56	MP0003123_paternal_imprinting	1.17478065
57	MP0003941_abnormal_skin_development	1.17445138
58	MP0004742_abnormal_vestibular_system	1.16905243
59	MP0008932_abnormal_embryonic_tissue	1.16112389
60	MP0001764_abnormal_homeostasis	1.14190003
61	MP0009745_abnormal_behavioral_response	1.09659769
62	MP0002751_abnormal_autonomic_nervous	1.09424960
63	MP0005408_hypopigmentation	1.07236006
64	MP0005389_reproductive_system_phenotype	1.07193209
65	MP0001485_abnormal_pinna_reflex	1.06216875
66	MP0003011_delayed_dark_adaptation	1.06075732
67	MP0005410_abnormal_fertilization	1.05960673
68	MP0003890_abnormal_embryonic-extraembry	1.04574587
69	MP0004043_abnormal_pH_regulation	1.04506034
70	MP0004270_analgesia	1.03735628
71	MP0000778_abnormal_nervous_system	1.02894128
72	MP0008007_abnormal_cellular_replicative	1.01193113
73	MP0009053_abnormal_anal_canal	1.01003320
74	MP0002638_abnormal_pupillary_reflex	0.98537781
75	MP0002735_abnormal_chemical_nociception	0.97551839
76	MP0003937_abnormal_limbs/digits/tail_de	0.95561497
77	MP0008789_abnormal_olfactory_epithelium	0.94750593
78	MP0002734_abnormal_mechanical_nocicepti	0.94584595
79	MP0003943_abnormal_hepatobiliary_system	0.94513184
80	MP0005386_behavior/neurological_phenoty	0.93597419
81	MP0004924_abnormal_behavior	0.93597419
82	MP0005085_abnormal_gallbladder_physiolo	0.91794723
83	MP0003183_abnormal_peptide_metabolism	0.90119192
84	MP0003077_abnormal_cell_cycle	0.87976045
85	MP0002233_abnormal_nose_morphology	0.87924224
86	MP0009250_abnormal_appendicular_skeleto	0.86380765
87	MP0006292_abnormal_olfactory_placode	0.85896330
88	MP0005391_vision/eye_phenotype	0.84183892
89	MP0006035_abnormal_mitochondrial_morpho	0.84069650
90	MP0002067_abnormal_sensory_capabilities	0.83678289
91	MP0003567_abnormal_fetal_cardiomyocyte	0.82398956
92	MP0002064_seizures	0.80611472
93	MP0002822_catalepsy	0.78509147
94	MP0002161_abnormal_fertility/fecundity	0.76844963
95	MP0003950_abnormal_plasma_membrane	0.75495346
96	MP0000358_abnormal_cell_content/	0.74974774
97	MP0002572_abnormal_emotion/affect_behav	0.74939980
98	MP0003635_abnormal_synaptic_transmissio	0.74470205
99	MP0004019_abnormal_vitamin_homeostasis	0.73899574
100	MP0009697_abnormal_copulation	0.72767257

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.31839471
2	Follicular hyperkeratosis (HP:0007502)	3.63742425
3	Volvulus (HP:0002580)	3.61243836
4	Broad distal phalanx of finger (HP:0009836)	3.55118484
5	Abnormality of the labia minora (HP:0012880)	3.52220371
6	Oligodactyly (hands) (HP:0001180)	3.46874148
7	Congenital, generalized hypertrichosis (HP:0004540)	3.13836993
8	Postaxial foot polydactyly (HP:0001830)	3.04817885
9	Pendular nystagmus (HP:0012043)	2.83693388
10	Congenital sensorineural hearing impairment (HP:0008527)	2.80425367
11	Pancreatic fibrosis (HP:0100732)	2.78771409
12	Ependymoma (HP:0002888)	2.74807098
13	Astrocytoma (HP:0009592)	2.70929768
14	Abnormality of the astrocytes (HP:0100707)	2.70929768
15	Type II lissencephaly (HP:0007260)	2.70320387
16	Medial flaring of the eyebrow (HP:0010747)	2.61179419
17	True hermaphroditism (HP:0010459)	2.55185607
18	Agnosia (HP:0010524)	2.52568892
19	Hip dysplasia (HP:0001385)	2.48313942
20	Pancreatic cysts (HP:0001737)	2.47829956
21	Gonadotropin excess (HP:0000837)	2.47561773
22	Abnormality of chromosome stability (HP:0003220)	2.46698340
23	Pili torti (HP:0003777)	2.46631618
24	Small hand (HP:0200055)	2.44077328
25	Widely spaced teeth (HP:0000687)	2.41607746
26	Absent speech (HP:0001344)	2.41009306
27	Astigmatism (HP:0000483)	2.38554388
28	Abnormal lung lobation (HP:0002101)	2.35458208
29	Abnormality of midbrain morphology (HP:0002418)	2.34825402
30	Molar tooth sign on MRI (HP:0002419)	2.34825402
31	Oligodactyly (HP:0012165)	2.34635300
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.33999101
33	Methylmalonic acidemia (HP:0002912)	2.31559456
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30864415
35	Renal hypoplasia (HP:0000089)	2.30767996
36	Abnormality of macular pigmentation (HP:0008002)	2.27741945
37	Postaxial hand polydactyly (HP:0001162)	2.27494313
38	Gaze-evoked nystagmus (HP:0000640)	2.26971247
39	Congenital primary aphakia (HP:0007707)	2.25032846
40	Rhabdomyosarcoma (HP:0002859)	2.24716497
41	Gait imbalance (HP:0002141)	2.24596129
42	Horizontal nystagmus (HP:0000666)	2.23648411
43	Patellar aplasia (HP:0006443)	2.22437808
44	Protruding tongue (HP:0010808)	2.21399975
45	Pancreatic islet-cell hyperplasia (HP:0004510)	2.20996199
46	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.20960730
47	Glioma (HP:0009733)	2.18543114
48	Colon cancer (HP:0003003)	2.18238161
49	Cutaneous finger syndactyly (HP:0010554)	2.16818242
50	Birth length less than 3rd percentile (HP:0003561)	2.16731376
51	Chronic hepatic failure (HP:0100626)	2.14232533
52	Vitreoretinal degeneration (HP:0000655)	2.12587954
53	Preaxial hand polydactyly (HP:0001177)	2.11955197
54	Hyperglycinuria (HP:0003108)	2.10488034
55	Methylmalonic aciduria (HP:0012120)	2.08343862
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08105042
57	Progressive inability to walk (HP:0002505)	2.07609492
58	Nephronophthisis (HP:0000090)	2.06962101
59	Hyperventilation (HP:0002883)	2.05772772
60	Retinal dysplasia (HP:0007973)	2.05684066
61	Aplasia/Hypoplasia of the patella (HP:0006498)	2.05232376
62	Absent eyebrow (HP:0002223)	2.04306155
63	Short foot (HP:0001773)	2.02361212
64	Hyperglycinemia (HP:0002154)	1.99121741
65	Meckel diverticulum (HP:0002245)	1.98735096
66	Ectopic kidney (HP:0000086)	1.98277729
67	Medulloblastoma (HP:0002885)	1.96610605
68	Genital tract atresia (HP:0001827)	1.96128929
69	Abnormality of the ileum (HP:0001549)	1.96019027
70	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95383585
71	Abnormality of serine family amino acid metabolism (HP:0010894)	1.94760202
72	Abnormality of glycine metabolism (HP:0010895)	1.94760202
73	Nephrogenic diabetes insipidus (HP:0009806)	1.91536907
74	Limb hypertonia (HP:0002509)	1.90441095
75	11 pairs of ribs (HP:0000878)	1.88448848
76	Thyroid-stimulating hormone excess (HP:0002925)	1.85996638
77	Attenuation of retinal blood vessels (HP:0007843)	1.85952908
78	Abolished electroretinogram (ERG) (HP:0000550)	1.85567034
79	Tubulointerstitial abnormality (HP:0001969)	1.85015241
80	Inappropriate behavior (HP:0000719)	1.84891221
81	Absent radius (HP:0003974)	1.83889402
82	Cystic hygroma (HP:0000476)	1.83768683
83	Cutaneous syndactyly (HP:0012725)	1.83713840
84	Vaginal atresia (HP:0000148)	1.83397527
85	Abnormality of the preputium (HP:0100587)	1.82283681
86	Clitoromegaly (HP:0000057)	1.81673670
87	Abnormality of the lower motor neuron (HP:0002366)	1.81522156
88	Duodenal stenosis (HP:0100867)	1.80824476
89	Small intestinal stenosis (HP:0012848)	1.80824476
90	Abnormality of the renal cortex (HP:0011035)	1.78246097
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.78090882
92	Optic nerve hypoplasia (HP:0000609)	1.77169513
93	Aplasia involving forearm bones (HP:0009822)	1.76955062
94	Absent forearm bone (HP:0003953)	1.76955062
95	Azoospermia (HP:0000027)	1.75318816
96	Decreased central vision (HP:0007663)	1.74357419
97	Abnormality of homocysteine metabolism (HP:0010919)	1.73774871
98	Homocystinuria (HP:0002156)	1.73774871
99	Amyotrophic lateral sclerosis (HP:0007354)	1.73169863
100	Anencephaly (HP:0002323)	1.72981701

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	7.03363653
2	FRK	5.66391850
3	PNCK	3.47646410
4	BMPR1B	3.02492765
5	WEE1	2.87181307
6	ACVR1B	2.77231602
7	STK38L	2.66556893
8	WNK3	2.35580109
9	STK16	2.27762980
10	PLK4	2.15483573
11	MKNK2	1.95241540
12	TRIM28	1.80523501
13	BUB1	1.77687985
14	CASK	1.74075555
15	AKT3	1.69239030
16	NEK1	1.63316958
17	NEK6	1.53044774
18	PBK	1.52574096
19	TNIK	1.51761441
20	TTK	1.49450982
21	BRSK2	1.48316010
22	INSRR	1.47663953
23	NUAK1	1.47309408
24	MAP3K4	1.38694993
25	MKNK1	1.23784538
26	PLK3	1.23258354
27	STK38	1.18662568
28	CAMKK2	1.17440678
29	MAPK13	1.17294714
30	TGFBR1	1.13475894
31	OXSR1	1.10479335
32	STK39	1.09774203
33	GRK1	1.03984737
34	ADRBK2	1.02682026
35	MAP4K2	1.00995900
36	NTRK2	0.98419897
37	ZAK	0.96107968
38	EIF2AK1	0.93492183
39	EPHA4	0.93124472
40	CDC7	0.91299844
41	PLK1	0.82930186
42	VRK1	0.79412034
43	PLK2	0.76615398
44	MET	0.76117985
45	EIF2AK3	0.75573024
46	MARK1	0.74321279
47	CCNB1	0.72159737
48	PRKCG	0.67260488
49	PAK3	0.66772765
50	TSSK6	0.65146787
51	SRPK1	0.65139977
52	PRKCE	0.63899759
53	ERBB3	0.63867689
54	ATM	0.63556692
55	BRD4	0.61900292
56	FGFR2	0.60474284
57	CLK1	0.58946077
58	ATR	0.58410355
59	MAPK7	0.56051131
60	SGK2	0.54663932
61	CHEK2	0.54035033
62	TNK2	0.51409921
63	WNK4	0.50203825
64	CDK8	0.48829855
65	BRSK1	0.46732381
66	CAMK4	0.45362136
67	UHMK1	0.44370170
68	MINK1	0.43280434
69	NEK2	0.43058951
70	EIF2AK2	0.42558481
71	CDK3	0.41291758
72	EPHB2	0.40221600
73	CAMK2A	0.39549153
74	IRAK4	0.37912728
75	TIE1	0.36527595
76	CHEK1	0.36135589
77	PRKDC	0.35824688
78	PTK2B	0.34813689
79	CAMK1	0.34380918
80	PKN1	0.33330802
81	SGK1	0.32586943
82	ERBB4	0.32056165
83	CAMK2B	0.30873422
84	BRAF	0.30871271
85	SGK223	0.29956876
86	SGK494	0.29956876
87	CSNK1D	0.29650420
88	MAP2K7	0.29063034
89	DYRK3	0.28859224
90	STK3	0.28733487
91	LATS1	0.27900617
92	PRKG1	0.27836399
93	ERBB2	0.27569285
94	PRKACB	0.27411876
95	BCR	0.27183882
96	PRKACA	0.27061076
97	PINK1	0.26877929
98	PRKCI	0.26074375
99	NME1	0.24773874
100	CDK1	0.24004952

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.78053012
2	Mismatch repair_Homo sapiens_hsa03430	3.37858954
3	Homologous recombination_Homo sapiens_hsa03440	3.15877451
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.63802307
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.62579662
6	Basal transcription factors_Homo sapiens_hsa03022	2.19289898
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.13670834
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.12733089
9	Propanoate metabolism_Homo sapiens_hsa00640	2.05836040
10	Proteasome_Homo sapiens_hsa03050	2.05004893
11	Protein export_Homo sapiens_hsa03060	1.98871712
12	Fatty acid degradation_Homo sapiens_hsa00071	1.92685427
13	beta-Alanine metabolism_Homo sapiens_hsa00410	1.89209544
14	Butanoate metabolism_Homo sapiens_hsa00650	1.88397621
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.79378397
16	Fatty acid metabolism_Homo sapiens_hsa01212	1.78552250
17	DNA replication_Homo sapiens_hsa03030	1.74038292
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73700306
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.69143513
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.63734249
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.63490267
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.59993984
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.58864411
24	Olfactory transduction_Homo sapiens_hsa04740	1.57707884
25	Phototransduction_Homo sapiens_hsa04744	1.55854070
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49745092
27	Nicotine addiction_Homo sapiens_hsa05033	1.47487248
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47361486
29	RNA transport_Homo sapiens_hsa03013	1.46230965
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44376516
31	RNA degradation_Homo sapiens_hsa03018	1.43455084
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41670317
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.38879551
34	Oocyte meiosis_Homo sapiens_hsa04114	1.38627992
35	ABC transporters_Homo sapiens_hsa02010	1.36801083
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33644807
37	One carbon pool by folate_Homo sapiens_hsa00670	1.32867737
38	Cell cycle_Homo sapiens_hsa04110	1.32660776
39	Base excision repair_Homo sapiens_hsa03410	1.29431438
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17714031
41	Peroxisome_Homo sapiens_hsa04146	1.17057079
42	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.16540315
43	Glycerolipid metabolism_Homo sapiens_hsa00561	1.12621032
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.10590999
45	Fatty acid elongation_Homo sapiens_hsa00062	1.09087927
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00993304
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00504974
48	Lysine degradation_Homo sapiens_hsa00310	0.98244013
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94457646
50	RNA polymerase_Homo sapiens_hsa03020	0.92661268
51	Caffeine metabolism_Homo sapiens_hsa00232	0.92627456
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.91686808
53	Circadian rhythm_Homo sapiens_hsa04710	0.90855919
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86884932
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84133898
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81714700
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81415904
58	Histidine metabolism_Homo sapiens_hsa00340	0.81242174
59	Purine metabolism_Homo sapiens_hsa00230	0.73747023
60	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.73415472
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.73252009
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71567203
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.69398693
64	Taste transduction_Homo sapiens_hsa04742	0.68623341
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.66034189
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63137656
67	Retinol metabolism_Homo sapiens_hsa00830	0.63125990
68	PPAR signaling pathway_Homo sapiens_hsa03320	0.62691905
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58531220
70	p53 signaling pathway_Homo sapiens_hsa04115	0.57696932
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53372840
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53051090
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52508685
74	Regulation of autophagy_Homo sapiens_hsa04140	0.51963478
75	Huntingtons disease_Homo sapiens_hsa05016	0.51113191
76	Spliceosome_Homo sapiens_hsa03040	0.50677747
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49376361
78	Metabolic pathways_Homo sapiens_hsa01100	0.48356782
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48041450
80	Circadian entrainment_Homo sapiens_hsa04713	0.45758830
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43671552
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42608621
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41638319
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38871110
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.38149951
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36626822
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36480782
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.36418734
89	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35927909
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35459028
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.32720098
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31379384
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30786277
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30051029
95	Long-term depression_Homo sapiens_hsa04730	0.29503848
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.28718244
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.27906582
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.27609914
99	Bile secretion_Homo sapiens_hsa04976	0.25185843
100	Parkinsons disease_Homo sapiens_hsa05012	0.25055880

RPS3AP35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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