ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.73076850
2	ribosomal large subunit biogenesis (GO:0042273)	5.48470840
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.98770610
4	ATP synthesis coupled proton transport (GO:0015986)	4.98770610
5	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.78888519
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.77385874
7	viral transcription (GO:0019083)	4.75008838
8	translational termination (GO:0006415)	4.59199895
9	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.39573885
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.27050083
11	cotranslational protein targeting to membrane (GO:0006613)	4.16174994
12	translational elongation (GO:0006414)	4.10842653
13	protein targeting to ER (GO:0045047)	4.08799554
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.92238139
15	protein localization to endoplasmic reticulum (GO:0070972)	3.91773156
16	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.82922636
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.81592801
18	regulation of hypersensitivity (GO:0002883)	3.79226544
19	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.78639983
20	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.73895061
21	protein neddylation (GO:0045116)	3.73408406
22	positive regulation of interleukin-17 production (GO:0032740)	3.59469782
23	translational initiation (GO:0006413)	3.50283615
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.38512062
25	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.38468878
26	positive regulation of mast cell degranulation (GO:0043306)	3.38468878
27	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.35482770
28	respiratory electron transport chain (GO:0022904)	3.35298696
29	electron transport chain (GO:0022900)	3.31213678
30	viral life cycle (GO:0019058)	3.28596010
31	cellular protein complex disassembly (GO:0043624)	3.27760697
32	DNA deamination (GO:0045006)	3.23422990
33	negative regulation of heart rate (GO:0010459)	3.22060381
34	GPI anchor biosynthetic process (GO:0006506)	3.15826717
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13529508
36	proteasome assembly (GO:0043248)	3.13513925
37	GPI anchor metabolic process (GO:0006505)	3.10921248
38	one-carbon compound transport (GO:0019755)	3.09681920
39	translation (GO:0006412)	3.07226474
40	forebrain morphogenesis (GO:0048853)	3.06271696
41	immunoglobulin mediated immune response (GO:0016064)	3.05914653
42	mast cell activation (GO:0045576)	3.04038147
43	positive regulation of mast cell activation (GO:0033005)	2.99038985
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97653419
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97653419
46	neutrophil activation involved in immune response (GO:0002283)	2.90838696
47	aldehyde catabolic process (GO:0046185)	2.83640763
48	ATP biosynthetic process (GO:0006754)	2.82289120
49	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.79915286
50	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.77075650
51	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.76959433
52	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.72154348
53	cullin deneddylation (GO:0010388)	2.72149836
54	formation of translation preinitiation complex (GO:0001731)	2.72127663
55	kynurenine metabolic process (GO:0070189)	2.71493647
56	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.71423214
57	B cell mediated immunity (GO:0019724)	2.71192980
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.70823989
59	regulation of germinal center formation (GO:0002634)	2.70109736
60	regulation of B cell receptor signaling pathway (GO:0050855)	2.68833607
61	axoneme assembly (GO:0035082)	2.68128465
62	maturation of SSU-rRNA (GO:0030490)	2.67487879
63	tryptophan catabolic process (GO:0006569)	2.67005332
64	indole-containing compound catabolic process (GO:0042436)	2.67005332
65	indolalkylamine catabolic process (GO:0046218)	2.67005332
66	protein targeting to membrane (GO:0006612)	2.66774895
67	purine deoxyribonucleotide catabolic process (GO:0009155)	2.65523024
68	platelet dense granule organization (GO:0060155)	2.64672541
69	aggressive behavior (GO:0002118)	2.64326099
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.63581952
71	NADH dehydrogenase complex assembly (GO:0010257)	2.63581952
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.63581952
73	organelle disassembly (GO:1903008)	2.62552829
74	base-excision repair, AP site formation (GO:0006285)	2.61013492
75	regulation of interleukin-17 production (GO:0032660)	2.58719046
76	urate metabolic process (GO:0046415)	2.57000906
77	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.55958448
78	mRNA catabolic process (GO:0006402)	2.55381840
79	positive regulation of protein homodimerization activity (GO:0090073)	2.54688178
80	piRNA metabolic process (GO:0034587)	2.54238809
81	protein complex disassembly (GO:0043241)	2.53517409
82	protein complex biogenesis (GO:0070271)	2.53118045
83	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.52361984
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51206563
85	macromolecular complex disassembly (GO:0032984)	2.51094298
86	positive regulation of response to biotic stimulus (GO:0002833)	2.50272411
87	deoxyribose phosphate catabolic process (GO:0046386)	2.48736764
88	negative regulation of mast cell activation (GO:0033004)	2.48443519
89	respiratory chain complex IV assembly (GO:0008535)	2.47161040
90	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.46500567
91	chaperone-mediated protein transport (GO:0072321)	2.46385260
92	indolalkylamine metabolic process (GO:0006586)	2.45257188
93	hydrogen ion transmembrane transport (GO:1902600)	2.44129491
94	RNA catabolic process (GO:0006401)	2.42700097
95	cell wall macromolecule metabolic process (GO:0044036)	2.41117129
96	response to pheromone (GO:0019236)	2.40599516
97	proton transport (GO:0015992)	2.37312207
98	histone mRNA metabolic process (GO:0008334)	2.37254748
99	GTP biosynthetic process (GO:0006183)	2.37014511
100	mast cell activation involved in immune response (GO:0002279)	2.35520096

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.71043318
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.16104578
3	VDR_22108803_ChIP-Seq_LS180_Human	3.13222094
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.81918375
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.77028924
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62781557
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50899182
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50694915
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.41365033
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31433644
11	EWS_26573619_Chip-Seq_HEK293_Human	2.28866825
12	FUS_26573619_Chip-Seq_HEK293_Human	2.22728052
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.22634322
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.20183347
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17550434
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.17541205
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.13878659
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.12269110
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09425612
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08951155
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05400818
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.03066246
23	P300_19829295_ChIP-Seq_ESCs_Human	1.95860230
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.84924048
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.81483807
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.80730332
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.75968170
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74712681
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.69009328
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.67494861
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.67431634
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.67431634
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67006034
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.63829164
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.61565854
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.60976646
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57635178
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56523153
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.52844146
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.49997897
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49877602
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49877602
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48311664
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.47851837
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.46495820
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43365160
47	AR_20517297_ChIP-Seq_VCAP_Human	1.37224116
48	GATA3_26560356_Chip-Seq_TH2_Human	1.33594073
49	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.32780530
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31263326
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31234246
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31141329
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30845772
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30503235
55	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.30254509
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28009468
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.27821193
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27821193
59	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25455143
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25016926
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22619279
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20944853
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20384779
64	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19766720
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.19448379
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19156479
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16919689
68	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12877002
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12716356
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11695250
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10945661
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.10041361
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09640490
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09472282
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09453871
76	MYB_26560356_Chip-Seq_TH2_Human	1.09427090
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09168457
78	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.08092590
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05750359
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05607780
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03466844
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02239335
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02236703
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01600359
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.01553351
86	GBX2_23144817_ChIP-Seq_PC3_Human	1.01525163
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00572889
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99617277
89	NCOR_22424771_ChIP-Seq_293T_Human	0.99206209
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.99003427
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97806372
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97766519
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95858511
94	SPI1_23547873_ChIP-Seq_NB4_Human	0.95327944
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94891430
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94671841
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94564489
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94552960
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94483876
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94223870

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.24118544
2	MP0005671_abnormal_response_to	3.52153044
3	MP0006292_abnormal_olfactory_placode	3.21069147
4	MP0009379_abnormal_foot_pigmentation	2.41491080
5	MP0001873_stomach_inflammation	2.31500104
6	MP0006072_abnormal_retinal_apoptosis	2.23668784
7	MP0002837_dystrophic_cardiac_calcinosis	2.20657286
8	MP0009785_altered_susceptibility_to	2.19491700
9	MP0004147_increased_porphyrin_level	2.18133574
10	MP0003806_abnormal_nucleotide_metabolis	2.14304582
11	MP0002166_altered_tumor_susceptibility	2.07188227
12	MP0001800_abnormal_humoral_immune	2.05759798
13	MP0002148_abnormal_hypersensitivity_rea	2.02012263
14	MP0005084_abnormal_gallbladder_morpholo	1.95810479
15	MP0008872_abnormal_physiological_respon	1.89841980
16	MP0005075_abnormal_melanosome_morpholog	1.89478063
17	MP0008877_abnormal_DNA_methylation	1.88873170
18	MP0008995_early_reproductive_senescence	1.74552676
19	MP0005000_abnormal_immune_tolerance	1.73459144
20	MP0005367_renal/urinary_system_phenotyp	1.68266361
21	MP0000516_abnormal_urinary_system	1.68266361
22	MP0005645_abnormal_hypothalamus_physiol	1.66704437
23	MP0002006_tumorigenesis	1.63290358
24	MP0003724_increased_susceptibility_to	1.63219530
25	MP0005646_abnormal_pituitary_gland	1.61291626
26	MP0004142_abnormal_muscle_tone	1.57124190
27	MP0002102_abnormal_ear_morphology	1.57051528
28	MP0003195_calcinosis	1.55370937
29	MP0003880_abnormal_central_pattern	1.53406519
30	MP0002452_abnormal_antigen_presenting	1.48585714
31	MP0004145_abnormal_muscle_electrophysio	1.48501186
32	MP0000685_abnormal_immune_system	1.43549227
33	MP0002876_abnormal_thyroid_physiology	1.43248875
34	MP0005551_abnormal_eye_electrophysiolog	1.42004031
35	MP0002234_abnormal_pharynx_morphology	1.40835647
36	MP0001986_abnormal_taste_sensitivity	1.39820116
37	MP0002723_abnormal_immune_serum	1.39797111
38	MP0009764_decreased_sensitivity_to	1.32773721
39	MP0008875_abnormal_xenobiotic_pharmacok	1.31871550
40	MP0002163_abnormal_gland_morphology	1.31495037
41	MP0005387_immune_system_phenotype	1.30884162
42	MP0001790_abnormal_immune_system	1.30884162
43	MP0003646_muscle_fatigue	1.25843596
44	MP0001529_abnormal_vocalization	1.25548281
45	MP0000681_abnormal_thyroid_gland	1.24856283
46	MP0001819_abnormal_immune_cell	1.24846402
47	MP0009333_abnormal_splenocyte_physiolog	1.24759667
48	MP0002420_abnormal_adaptive_immunity	1.23398220
49	MP0003763_abnormal_thymus_physiology	1.23220282
50	MP0005253_abnormal_eye_physiology	1.22460423
51	MP0009697_abnormal_copulation	1.20732066
52	MP0001905_abnormal_dopamine_level	1.19942021
53	MP0002160_abnormal_reproductive_system	1.19424885
54	MP0006276_abnormal_autonomic_nervous	1.15390625
55	MP0003283_abnormal_digestive_organ	1.15308340
56	MP0000372_irregular_coat_pigmentation	1.11796035
57	MP0005389_reproductive_system_phenotype	1.11123160
58	MP0006036_abnormal_mitochondrial_physio	1.08550365
59	MP0004885_abnormal_endolymph	1.06348503
60	MP0005379_endocrine/exocrine_gland_phen	1.04648157
61	MP0008058_abnormal_DNA_repair	1.03438506
62	MP0005025_abnormal_response_to	1.00925014
63	MP0002405_respiratory_system_inflammati	1.00874010
64	MP0000569_abnormal_digit_pigmentation	0.98804862
65	MP0010155_abnormal_intestine_physiology	0.98244102
66	MP0000716_abnormal_immune_system	0.97718722
67	MP0001968_abnormal_touch/_nociception	0.97210852
68	MP0003786_premature_aging	0.96871732
69	MP0002398_abnormal_bone_marrow	0.96664526
70	MP0000465_gastrointestinal_hemorrhage	0.94518394
71	MP0003787_abnormal_imprinting	0.93870234
72	MP0004782_abnormal_surfactant_physiolog	0.93414168
73	MP0001764_abnormal_homeostasis	0.93392457
74	MP0005085_abnormal_gallbladder_physiolo	0.92816719
75	MP0008961_abnormal_basal_metabolism	0.92508421
76	MP0002095_abnormal_skin_pigmentation	0.91849084
77	MP0003567_abnormal_fetal_cardiomyocyte	0.90074035
78	MP0000049_abnormal_middle_ear	0.88933639
79	MP0001845_abnormal_inflammatory_respons	0.88221351
80	MP0002272_abnormal_nervous_system	0.88011205
81	MP0003866_abnormal_defecation	0.87634761
82	MP0001664_abnormal_digestion	0.87456092
83	MP0002419_abnormal_innate_immunity	0.86875646
84	MP0002735_abnormal_chemical_nociception	0.85288074
85	MP0002736_abnormal_nociception_after	0.85230687
86	MP0000689_abnormal_spleen_morphology	0.84102343
87	MP0006082_CNS_inflammation	0.83744204
88	MP0002138_abnormal_hepatobiliary_system	0.82114201
89	MP0000631_abnormal_neuroendocrine_gland	0.80435721
90	MP0001293_anophthalmia	0.80328330
91	MP0005636_abnormal_mineral_homeostasis	0.79257458
92	MP0001501_abnormal_sleep_pattern	0.77911533
93	MP0008469_abnormal_protein_level	0.77721219
94	MP0003011_delayed_dark_adaptation	0.77125610
95	MP0009745_abnormal_behavioral_response	0.76274048
96	MP0002822_catalepsy	0.76243560
97	MP0001486_abnormal_startle_reflex	0.74478837
98	MP0005410_abnormal_fertilization	0.74175303
99	MP0003186_abnormal_redox_activity	0.74063797
100	MP0001919_abnormal_reproductive_system	0.73132647

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.25873957
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.86000468
3	Absent/shortened dynein arms (HP:0200106)	3.86000468
4	Mitochondrial inheritance (HP:0001427)	3.52242052
5	Increased hepatocellular lipid droplets (HP:0006565)	3.38876716
6	3-Methylglutaconic aciduria (HP:0003535)	3.36118582
7	Stenosis of the external auditory canal (HP:0000402)	3.35348955
8	Acute necrotizing encephalopathy (HP:0006965)	3.34936264
9	Abnormality of B cell number (HP:0010975)	3.31836764
10	Congenital, generalized hypertrichosis (HP:0004540)	3.31172765
11	Congenital stationary night blindness (HP:0007642)	3.27951467
12	Hepatocellular necrosis (HP:0001404)	3.17722762
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.14413633
14	Hypoproteinemia (HP:0003075)	3.12766779
15	Lipid accumulation in hepatocytes (HP:0006561)	3.07543181
16	B lymphocytopenia (HP:0010976)	3.07233451
17	Increased CSF lactate (HP:0002490)	3.06325091
18	IgG deficiency (HP:0004315)	2.92279482
19	Abnormality of midbrain morphology (HP:0002418)	2.90531716
20	Molar tooth sign on MRI (HP:0002419)	2.90531716
21	Progressive macrocephaly (HP:0004481)	2.90203471
22	Abolished electroretinogram (ERG) (HP:0000550)	2.88697125
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.85817095
24	Renal Fanconi syndrome (HP:0001994)	2.81574767
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.80827623
26	Acute encephalopathy (HP:0006846)	2.78428074
27	Abnormality of the prostate (HP:0008775)	2.75119895
28	Exertional dyspnea (HP:0002875)	2.72762679
29	Attenuation of retinal blood vessels (HP:0007843)	2.71395282
30	Abnormal ciliary motility (HP:0012262)	2.70895537
31	Decreased central vision (HP:0007663)	2.70226318
32	Constricted visual fields (HP:0001133)	2.66745490
33	Thyroiditis (HP:0100646)	2.66024764
34	Severe combined immunodeficiency (HP:0004430)	2.65509931
35	Chronic sinusitis (HP:0011109)	2.65508810
36	Hepatic necrosis (HP:0002605)	2.65406434
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.61700402
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.61700402
39	Cerebral edema (HP:0002181)	2.61073383
40	Increased intramyocellular lipid droplets (HP:0012240)	2.60499406
41	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.50118362
42	Pancreatic cysts (HP:0001737)	2.49872262
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.49249171
44	Panhypogammaglobulinemia (HP:0003139)	2.49015955
45	Optic disc pallor (HP:0000543)	2.48101353
46	Macrocytic anemia (HP:0001972)	2.45828851
47	Methylmalonic acidemia (HP:0002912)	2.44005696
48	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.43506454
49	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.34581629
50	Reticulocytopenia (HP:0001896)	2.31550446
51	Stomatitis (HP:0010280)	2.28333283
52	True hermaphroditism (HP:0010459)	2.24270101
53	Abnormal respiratory motile cilium physiology (HP:0012261)	2.22646670
54	Abnormal hemoglobin (HP:0011902)	2.21419454
55	Pancreatic fibrosis (HP:0100732)	2.17774695
56	Nephronophthisis (HP:0000090)	2.16563224
57	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.15626740
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.15626740
59	Pallor (HP:0000980)	2.08591406
60	Increased muscle lipid content (HP:0009058)	2.06551504
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06366439
62	Lactic acidosis (HP:0003128)	2.03789958
63	Abnormality of eosinophils (HP:0001879)	2.01948738
64	Type I transferrin isoform profile (HP:0003642)	2.01709466
65	Aplastic anemia (HP:0001915)	1.99069062
66	Abnormality of cells of the erythroid lineage (HP:0012130)	1.98086316
67	Myotonia (HP:0002486)	1.97641553
68	Glycosuria (HP:0003076)	1.94541646
69	Abnormality of urine glucose concentration (HP:0011016)	1.94541646
70	Asplenia (HP:0001746)	1.91863657
71	Increased serum lactate (HP:0002151)	1.91648930
72	Combined immunodeficiency (HP:0005387)	1.91643633
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91424404
74	Respiratory difficulties (HP:0002880)	1.90266466
75	Abnormality of renal resorption (HP:0011038)	1.88759558
76	Eosinophilia (HP:0001880)	1.88498273
77	Agammaglobulinemia (HP:0004432)	1.86301345
78	Medial flaring of the eyebrow (HP:0010747)	1.86179730
79	Abnormality of the renal medulla (HP:0100957)	1.85743907
80	Lethargy (HP:0001254)	1.84544216
81	Leukodystrophy (HP:0002415)	1.83896174
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82558178
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.81240799
84	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79551593
85	Abnormality of alanine metabolism (HP:0010916)	1.79551593
86	Hyperalaninemia (HP:0003348)	1.79551593
87	Supernumerary spleens (HP:0009799)	1.77918656
88	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.76108398
89	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.74562002
90	Hypothermia (HP:0002045)	1.73586848
91	Reduced antithrombin III activity (HP:0001976)	1.72869711
92	Thyroid-stimulating hormone excess (HP:0002925)	1.72805124
93	Hypoplasia of the thymus (HP:0000778)	1.72113391
94	Erythroderma (HP:0001019)	1.71130483
95	Respiratory failure (HP:0002878)	1.70016997
96	Abnormality of the renal cortex (HP:0011035)	1.67048766
97	Cerebral palsy (HP:0100021)	1.66267991
98	Type 2 muscle fiber atrophy (HP:0003554)	1.65696088
99	Vasculitis (HP:0002633)	1.65184587
100	Abnormality of DNA repair (HP:0003254)	1.64823561

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	5.20928323
2	BCKDK	4.09799776
3	MAP4K2	3.31993448
4	BMPR2	3.06867510
5	MAP3K12	2.56224472
6	EIF2AK3	2.53476263
7	FRK	2.24281735
8	GRK1	2.03322627
9	TAOK3	1.93785540
10	KIT	1.90849569
11	TXK	1.89316280
12	NUAK1	1.82466156
13	TEC	1.66597285
14	ZAK	1.66352617
15	TLK1	1.62853123
16	ADRBK2	1.61647130
17	ERBB3	1.52970366
18	FLT3	1.48054398
19	PINK1	1.46272458
20	MYLK	1.42745675
21	PASK	1.42435325
22	SYK	1.33159314
23	TRPM7	1.32755013
24	CSF1R	1.32420623
25	OXSR1	1.20496435
26	WNK3	1.20355922
27	KDR	1.17192134
28	IKBKB	1.16677426
29	MKNK1	1.15625175
30	CDK3	1.12654734
31	VRK1	1.10202404
32	ILK	1.10031865
33	INSRR	1.09745711
34	BTK	1.06473095
35	STK16	1.03458059
36	ITK	1.02842791
37	GRK6	1.01802223
38	MATK	1.01185309
39	MAP2K6	1.00144865
40	MST4	1.00122142
41	PIK3CG	0.98829319
42	RPS6KA4	0.98229197
43	MAP4K1	0.96528706
44	TRIM28	0.91364125
45	LYN	0.88422652
46	PBK	0.86294753
47	SCYL2	0.82922454
48	WNK4	0.82486126
49	VRK2	0.80236489
50	MAPK7	0.79240991
51	CDK8	0.77829916
52	MAPK13	0.77062907
53	PLK4	0.75554162
54	RPS6KA5	0.75046650
55	OBSCN	0.72864216
56	CSNK1G1	0.72288314
57	PRKCE	0.70286375
58	JAK3	0.69257736
59	FES	0.66712896
60	TIE1	0.63422928
61	LCK	0.63175523
62	MAP3K4	0.62883925
63	DAPK3	0.62733261
64	IGF1R	0.61193133
65	CAMKK2	0.61154953
66	GRK7	0.55082204
67	EIF2AK2	0.52897850
68	SRPK1	0.51887242
69	HCK	0.50939562
70	IKBKE	0.50280155
71	NME2	0.49908933
72	TNK2	0.49451270
73	DYRK2	0.49264631
74	PRKCD	0.48373328
75	PIK3CA	0.47327964
76	PLK3	0.46342405
77	CSNK1G3	0.45931448
78	PKN1	0.45697943
79	CSNK1G2	0.45629730
80	ATR	0.44816030
81	CSNK2A1	0.44665467
82	CSNK2A2	0.44173981
83	AURKB	0.44010049
84	ABL1	0.43429182
85	RIPK4	0.42849063
86	BCR	0.42549117
87	PRKACA	0.40221952
88	EGFR	0.39407767
89	PRKCA	0.39252409
90	CCNB1	0.39095097
91	ADRBK1	0.39004521
92	DAPK1	0.38857208
93	ZAP70	0.38448507
94	NLK	0.37948330
95	PRKG1	0.37890236
96	PLK2	0.37479780
97	PRKCQ	0.37042735
98	EPHA4	0.36948674
99	MAP2K7	0.36729126
100	RPS6KB2	0.36610416

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.20127221
2	Allograft rejection_Homo sapiens_hsa05330	3.95430839
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.55245810
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.55238138
5	Ribosome_Homo sapiens_hsa03010	3.47487062
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.40068832
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.29732028
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.97217212
9	Proteasome_Homo sapiens_hsa03050	2.48315841
10	Parkinsons disease_Homo sapiens_hsa05012	2.42380258
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.35287544
12	Protein export_Homo sapiens_hsa03060	2.31059349
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.02984932
14	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74700299
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.67535674
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59231160
17	Alzheimers disease_Homo sapiens_hsa05010	1.57731199
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.52204011
19	Homologous recombination_Homo sapiens_hsa03440	1.50269724
20	Viral myocarditis_Homo sapiens_hsa05416	1.44070369
21	Huntingtons disease_Homo sapiens_hsa05016	1.42084347
22	RNA degradation_Homo sapiens_hsa03018	1.39850842
23	RNA polymerase_Homo sapiens_hsa03020	1.32464253
24	Leishmaniasis_Homo sapiens_hsa05140	1.32057725
25	Phototransduction_Homo sapiens_hsa04744	1.29455209
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27137183
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26304057
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22083618
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.19995409
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18590275
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16048098
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11201921
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.09974559
34	Propanoate metabolism_Homo sapiens_hsa00640	1.09548417
35	Olfactory transduction_Homo sapiens_hsa04740	0.98449568
36	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.93200951
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91787467
38	Retinol metabolism_Homo sapiens_hsa00830	0.85953331
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80647838
40	Caffeine metabolism_Homo sapiens_hsa00232	0.77924290
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76528097
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75615451
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75285534
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71934548
45	Mismatch repair_Homo sapiens_hsa03430	0.71050788
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69653859
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.69616867
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69356300
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69046874
50	Basal transcription factors_Homo sapiens_hsa03022	0.68970733
51	Spliceosome_Homo sapiens_hsa03040	0.68784436
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68510839
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.66124196
54	RNA transport_Homo sapiens_hsa03013	0.66059648
55	Peroxisome_Homo sapiens_hsa04146	0.64277301
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.63810293
57	African trypanosomiasis_Homo sapiens_hsa05143	0.63230539
58	One carbon pool by folate_Homo sapiens_hsa00670	0.60491472
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60098268
60	Purine metabolism_Homo sapiens_hsa00230	0.59967755
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59513720
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59266602
63	Regulation of autophagy_Homo sapiens_hsa04140	0.58942878
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.58492295
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57200630
66	Legionellosis_Homo sapiens_hsa05134	0.56538725
67	Salivary secretion_Homo sapiens_hsa04970	0.56116910
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.55787550
69	Taste transduction_Homo sapiens_hsa04742	0.52390563
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51022958
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50933997
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50389623
73	Tuberculosis_Homo sapiens_hsa05152	0.46660345
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46395814
75	Herpes simplex infection_Homo sapiens_hsa05168	0.45032111
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43111970
77	Toxoplasmosis_Homo sapiens_hsa05145	0.40400574
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40334292
79	Butanoate metabolism_Homo sapiens_hsa00650	0.39485666
80	Nicotine addiction_Homo sapiens_hsa05033	0.38379086
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36590481
82	Metabolic pathways_Homo sapiens_hsa01100	0.36431159
83	Sulfur relay system_Homo sapiens_hsa04122	0.36107709
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36093074
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34979860
86	Serotonergic synapse_Homo sapiens_hsa04726	0.34416425
87	DNA replication_Homo sapiens_hsa03030	0.33443835
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33301609
89	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31657238
90	Sulfur metabolism_Homo sapiens_hsa00920	0.31567854
91	Base excision repair_Homo sapiens_hsa03410	0.31119436
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26881636
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26330728
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.25702792
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25194078
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25070281
97	Pertussis_Homo sapiens_hsa05133	0.24741999
98	Morphine addiction_Homo sapiens_hsa05032	0.23367768
99	Glutathione metabolism_Homo sapiens_hsa00480	0.21684834
100	GABAergic synapse_Homo sapiens_hsa04727	0.19989773

RPS3AP39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »