

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.61809774 |
| 2 | DNA deamination (GO:0045006) | 5.55166255 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 5.12646459 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.12646459 |
| 5 | termination of RNA polymerase III transcription (GO:0006386) | 5.00803778 |
| 6 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 5.00803778 |
| 7 | platelet dense granule organization (GO:0060155) | 4.68398108 |
| 8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.46434099 |
| 9 | cytidine deamination (GO:0009972) | 4.15969604 |
| 10 | cytidine metabolic process (GO:0046087) | 4.15969604 |
| 11 | cytidine catabolic process (GO:0006216) | 4.15969604 |
| 12 | respiratory electron transport chain (GO:0022904) | 4.09595146 |
| 13 | proteasome assembly (GO:0043248) | 4.07702010 |
| 14 | protein complex biogenesis (GO:0070271) | 4.04276056 |
| 15 | electron transport chain (GO:0022900) | 4.04265082 |
| 16 | protein neddylation (GO:0045116) | 3.89301306 |
| 17 | tryptophan catabolic process (GO:0006569) | 3.79807178 |
| 18 | indole-containing compound catabolic process (GO:0042436) | 3.79807178 |
| 19 | indolalkylamine catabolic process (GO:0046218) | 3.79807178 |
| 20 | NADH dehydrogenase complex assembly (GO:0010257) | 3.76131841 |
| 21 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.76131841 |
| 22 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.76131841 |
| 23 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.66948834 |
| 24 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.62557188 |
| 25 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.57406071 |
| 26 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.57406071 |
| 27 | ribosomal large subunit biogenesis (GO:0042273) | 3.55939826 |
| 28 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.53143540 |
| 29 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.51564513 |
| 30 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.48611476 |
| 31 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.39634634 |
| 32 | ribosomal small subunit assembly (GO:0000028) | 3.31064373 |
| 33 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.29456792 |
| 34 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.29456792 |
| 35 | tryptophan metabolic process (GO:0006568) | 3.20874659 |
| 36 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.15253082 |
| 37 | cellular response to interferon-beta (GO:0035458) | 3.14828320 |
| 38 | kynurenine metabolic process (GO:0070189) | 3.12939871 |
| 39 | cotranslational protein targeting to membrane (GO:0006613) | 3.11762059 |
| 40 | viral transcription (GO:0019083) | 3.07822762 |
| 41 | protein targeting to ER (GO:0045047) | 3.07769178 |
| 42 | translational termination (GO:0006415) | 3.03693501 |
| 43 | L-fucose catabolic process (GO:0042355) | 3.02714358 |
| 44 | fucose catabolic process (GO:0019317) | 3.02714358 |
| 45 | L-fucose metabolic process (GO:0042354) | 3.02714358 |
| 46 | protein localization to endoplasmic reticulum (GO:0070972) | 3.02493254 |
| 47 | indolalkylamine metabolic process (GO:0006586) | 2.95649423 |
| 48 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.91241580 |
| 49 | respiratory chain complex IV assembly (GO:0008535) | 2.91221213 |
| 50 | response to xenobiotic stimulus (GO:0009410) | 2.88234494 |
| 51 | translational elongation (GO:0006414) | 2.83067085 |
| 52 | translation (GO:0006412) | 2.82447629 |
| 53 | ATP biosynthetic process (GO:0006754) | 2.82395988 |
| 54 | behavioral response to nicotine (GO:0035095) | 2.81417448 |
| 55 | hydrogen ion transmembrane transport (GO:1902600) | 2.81182770 |
| 56 | maturation of 5.8S rRNA (GO:0000460) | 2.80268699 |
| 57 | response to interferon-beta (GO:0035456) | 2.80139028 |
| 58 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.78698782 |
| 59 | proton transport (GO:0015992) | 2.77746393 |
| 60 | negative regulation of mast cell activation (GO:0033004) | 2.76373381 |
| 61 | hydrogen transport (GO:0006818) | 2.74683506 |
| 62 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.74310364 |
| 63 | aldehyde catabolic process (GO:0046185) | 2.73443443 |
| 64 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.73129822 |
| 65 | peptidyl-histidine modification (GO:0018202) | 2.72668773 |
| 66 | anterograde synaptic vesicle transport (GO:0048490) | 2.72643046 |
| 67 | axoneme assembly (GO:0035082) | 2.68930821 |
| 68 | regulation of chronic inflammatory response (GO:0002676) | 2.68652371 |
| 69 | cytochrome complex assembly (GO:0017004) | 2.68620549 |
| 70 | chaperone-mediated protein transport (GO:0072321) | 2.68408989 |
| 71 | cell wall macromolecule metabolic process (GO:0044036) | 2.67727662 |
| 72 | regulation of regulatory T cell differentiation (GO:0045589) | 2.65784437 |
| 73 | transcription from RNA polymerase III promoter (GO:0006383) | 2.65263386 |
| 74 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.59672879 |
| 75 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.58758967 |
| 76 | mitotic cell cycle arrest (GO:0071850) | 2.58316495 |
| 77 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.57145532 |
| 78 | rRNA modification (GO:0000154) | 2.55140474 |
| 79 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.54562528 |
| 80 | positive regulation of protein homodimerization activity (GO:0090073) | 2.54279874 |
| 81 | inner mitochondrial membrane organization (GO:0007007) | 2.54150256 |
| 82 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.53929541 |
| 83 | mannosylation (GO:0097502) | 2.53690555 |
| 84 | piRNA metabolic process (GO:0034587) | 2.53330841 |
| 85 | response to pheromone (GO:0019236) | 2.49779517 |
| 86 | detection of light stimulus involved in visual perception (GO:0050908) | 2.49082946 |
| 87 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.49082946 |
| 88 | pseudouridine synthesis (GO:0001522) | 2.48412548 |
| 89 | cell wall macromolecule catabolic process (GO:0016998) | 2.48388507 |
| 90 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.47523650 |
| 91 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.47178355 |
| 92 | mast cell activation (GO:0045576) | 2.46039237 |
| 93 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.45895911 |
| 94 | GPI anchor biosynthetic process (GO:0006506) | 2.44708059 |
| 95 | cellular response to interleukin-15 (GO:0071350) | 2.44204918 |
| 96 | GTP biosynthetic process (GO:0006183) | 2.43786964 |
| 97 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.43286825 |
| 98 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.43286825 |
| 99 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.43286825 |
| 100 | S-adenosylmethionine metabolic process (GO:0046500) | 2.42930925 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.71300711 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.56203079 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.51422314 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.29105897 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.17243474 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.98635394 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.86272837 |
| 8 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.63888311 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.61654574 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.59314654 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.43208143 |
| 12 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.41584451 |
| 13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.25734215 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.25611383 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.20175828 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.12592193 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06003615 |
| 18 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.05122118 |
| 19 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.03748672 |
| 20 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.94341294 |
| 21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.92024889 |
| 22 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.91989797 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.85587749 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.81564992 |
| 25 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.76516093 |
| 26 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.74557543 |
| 27 | EWS_26573619_Chip-Seq_HEK293_Human | 1.74067405 |
| 28 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.64458254 |
| 29 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.59948198 |
| 30 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.57843518 |
| 31 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.57610375 |
| 32 | GATA3_26560356_Chip-Seq_TH2_Human | 1.57601513 |
| 33 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.53921828 |
| 34 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.53921828 |
| 35 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.52449249 |
| 36 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.46548404 |
| 37 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.44516467 |
| 38 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.44516467 |
| 39 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.44170697 |
| 40 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.41669038 |
| 41 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.39384383 |
| 42 | AR_20517297_ChIP-Seq_VCAP_Human | 1.39108733 |
| 43 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.38868592 |
| 44 | FUS_26573619_Chip-Seq_HEK293_Human | 1.38206809 |
| 45 | P300_19829295_ChIP-Seq_ESCs_Human | 1.35996133 |
| 46 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.33858560 |
| 47 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.32592173 |
| 48 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.29717893 |
| 49 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.25566631 |
| 50 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.25151104 |
| 51 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.22186541 |
| 52 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.20931825 |
| 53 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.20367419 |
| 54 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.19751517 |
| 55 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.18753504 |
| 56 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17820654 |
| 57 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.16731540 |
| 58 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.16644787 |
| 59 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.14576579 |
| 60 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.13682180 |
| 61 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.12834242 |
| 62 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.12217705 |
| 63 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.11021142 |
| 64 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.10739369 |
| 65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.10648072 |
| 66 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.10466002 |
| 67 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.10057285 |
| 68 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.09989910 |
| 69 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.09917134 |
| 70 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.09769345 |
| 71 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.08903553 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08487483 |
| 73 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.07907645 |
| 74 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.07117674 |
| 75 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06608413 |
| 76 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.05333627 |
| 77 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.05208465 |
| 78 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.05208465 |
| 79 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.04385307 |
| 80 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.04355493 |
| 81 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.03815429 |
| 82 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.03289892 |
| 83 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.01843237 |
| 84 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.01080376 |
| 85 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.00622349 |
| 86 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.00145560 |
| 87 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.00007354 |
| 88 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.99612360 |
| 89 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.99508760 |
| 90 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.98571950 |
| 91 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.97966450 |
| 92 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.97486464 |
| 93 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.95229181 |
| 94 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.94352284 |
| 95 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.92562350 |
| 96 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92233751 |
| 97 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.92068124 |
| 98 | NCOR_22424771_ChIP-Seq_293T_Human | 0.91841076 |
| 99 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91183105 |
| 100 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90285699 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.19290363 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.30771543 |
| 3 | MP0005671_abnormal_response_to | 3.29454744 |
| 4 | MP0009379_abnormal_foot_pigmentation | 2.77009241 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 2.56718443 |
| 6 | MP0004147_increased_porphyrin_level | 2.44510806 |
| 7 | MP0009785_altered_susceptibility_to | 2.32171058 |
| 8 | MP0005360_urolithiasis | 2.25598880 |
| 9 | MP0005075_abnormal_melanosome_morpholog | 2.23467772 |
| 10 | MP0004145_abnormal_muscle_electrophysio | 2.20774637 |
| 11 | MP0002254_reproductive_system_inflammat | 2.19268111 |
| 12 | MP0004142_abnormal_muscle_tone | 2.17643817 |
| 13 | MP0002148_abnormal_hypersensitivity_rea | 2.14115746 |
| 14 | MP0002876_abnormal_thyroid_physiology | 2.12288163 |
| 15 | MP0006072_abnormal_retinal_apoptosis | 2.11252558 |
| 16 | MP0005377_hearing/vestibular/ear_phenot | 2.07285348 |
| 17 | MP0003878_abnormal_ear_physiology | 2.07285348 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 1.97687083 |
| 19 | MP0000685_abnormal_immune_system | 1.96052555 |
| 20 | MP0001800_abnormal_humoral_immune | 1.92919314 |
| 21 | MP0002102_abnormal_ear_morphology | 1.83956573 |
| 22 | MP0005551_abnormal_eye_electrophysiolog | 1.81752830 |
| 23 | MP0005646_abnormal_pituitary_gland | 1.80915367 |
| 24 | MP0004885_abnormal_endolymph | 1.79801563 |
| 25 | MP0005387_immune_system_phenotype | 1.78098381 |
| 26 | MP0001790_abnormal_immune_system | 1.78098381 |
| 27 | MP0000372_irregular_coat_pigmentation | 1.77757385 |
| 28 | MP0008872_abnormal_physiological_respon | 1.74359385 |
| 29 | MP0006292_abnormal_olfactory_placode | 1.71101120 |
| 30 | MP0003011_delayed_dark_adaptation | 1.68626887 |
| 31 | MP0003195_calcinosis | 1.58113427 |
| 32 | MP0001501_abnormal_sleep_pattern | 1.56824027 |
| 33 | MP0002723_abnormal_immune_serum | 1.50944728 |
| 34 | MP0008877_abnormal_DNA_methylation | 1.48439724 |
| 35 | MP0005000_abnormal_immune_tolerance | 1.47047358 |
| 36 | MP0003786_premature_aging | 1.46443714 |
| 37 | MP0005645_abnormal_hypothalamus_physiol | 1.46223706 |
| 38 | MP0005253_abnormal_eye_physiology | 1.44925155 |
| 39 | MP0003186_abnormal_redox_activity | 1.38743999 |
| 40 | MP0002452_abnormal_antigen_presenting | 1.38217568 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.38098630 |
| 42 | MP0003283_abnormal_digestive_organ | 1.33605734 |
| 43 | MP0006082_CNS_inflammation | 1.31647373 |
| 44 | MP0003866_abnormal_defecation | 1.30194694 |
| 45 | MP0002736_abnormal_nociception_after | 1.28792990 |
| 46 | MP0003718_maternal_effect | 1.28606644 |
| 47 | MP0001819_abnormal_immune_cell | 1.26332425 |
| 48 | MP0003646_muscle_fatigue | 1.25442038 |
| 49 | MP0009764_decreased_sensitivity_to | 1.24094148 |
| 50 | MP0002420_abnormal_adaptive_immunity | 1.22844831 |
| 51 | MP0002138_abnormal_hepatobiliary_system | 1.21230201 |
| 52 | MP0004043_abnormal_pH_regulation | 1.20876904 |
| 53 | MP0009333_abnormal_splenocyte_physiolog | 1.19073360 |
| 54 | MP0009697_abnormal_copulation | 1.18810947 |
| 55 | MP0005167_abnormal_blood-brain_barrier | 1.17736322 |
| 56 | MP0008995_early_reproductive_senescence | 1.15926265 |
| 57 | MP0006036_abnormal_mitochondrial_physio | 1.13280618 |
| 58 | MP0001919_abnormal_reproductive_system | 1.11920836 |
| 59 | MP0005025_abnormal_response_to | 1.11525640 |
| 60 | MP0005389_reproductive_system_phenotype | 1.11049370 |
| 61 | MP0003787_abnormal_imprinting | 1.10327681 |
| 62 | MP0009745_abnormal_behavioral_response | 1.07375328 |
| 63 | MP0010155_abnormal_intestine_physiology | 1.06520031 |
| 64 | MP0001905_abnormal_dopamine_level | 1.05640902 |
| 65 | MP0001873_stomach_inflammation | 1.05391118 |
| 66 | MP0001986_abnormal_taste_sensitivity | 1.04189924 |
| 67 | MP0001348_abnormal_lacrimal_gland | 1.03630096 |
| 68 | MP0002272_abnormal_nervous_system | 1.00884136 |
| 69 | MP0001764_abnormal_homeostasis | 1.00736695 |
| 70 | MP0002166_altered_tumor_susceptibility | 0.98945621 |
| 71 | MP0002277_abnormal_respiratory_mucosa | 0.96967921 |
| 72 | MP0002822_catalepsy | 0.96150954 |
| 73 | MP0003567_abnormal_fetal_cardiomyocyte | 0.95443309 |
| 74 | MP0003724_increased_susceptibility_to | 0.95061001 |
| 75 | MP0006035_abnormal_mitochondrial_morpho | 0.94630804 |
| 76 | MP0005379_endocrine/exocrine_gland_phen | 0.93119354 |
| 77 | MP0005636_abnormal_mineral_homeostasis | 0.92448624 |
| 78 | MP0000716_abnormal_immune_system | 0.87520189 |
| 79 | MP0002095_abnormal_skin_pigmentation | 0.85780921 |
| 80 | MP0003638_abnormal_response/metabolism_ | 0.85744523 |
| 81 | MP0001845_abnormal_inflammatory_respons | 0.84961209 |
| 82 | MP0002006_tumorigenesis | 0.84786887 |
| 83 | MP0001970_abnormal_pain_threshold | 0.84335340 |
| 84 | MP0005332_abnormal_amino_acid | 0.83665906 |
| 85 | MP0002398_abnormal_bone_marrow | 0.82759729 |
| 86 | MP0003763_abnormal_thymus_physiology | 0.81905691 |
| 87 | MP0002139_abnormal_hepatobiliary_system | 0.80934848 |
| 88 | MP0000689_abnormal_spleen_morphology | 0.80127884 |
| 89 | MP0008469_abnormal_protein_level | 0.77932945 |
| 90 | MP0001440_abnormal_grooming_behavior | 0.77762758 |
| 91 | MP0001188_hyperpigmentation | 0.77198120 |
| 92 | MP0002733_abnormal_thermal_nociception | 0.77042450 |
| 93 | MP0003436_decreased_susceptibility_to | 0.76970071 |
| 94 | MP0001293_anophthalmia | 0.72379213 |
| 95 | MP0001853_heart_inflammation | 0.71980333 |
| 96 | MP0000631_abnormal_neuroendocrine_gland | 0.71508211 |
| 97 | MP0001529_abnormal_vocalization | 0.71041399 |
| 98 | MP0002163_abnormal_gland_morphology | 0.69717702 |
| 99 | MP0009046_muscle_twitch | 0.69515872 |
| 100 | MP0002735_abnormal_chemical_nociception | 0.69501994 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.67449518 |
| 2 | Acute encephalopathy (HP:0006846) | 4.09345136 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.06207073 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.02524767 |
| 5 | Progressive macrocephaly (HP:0004481) | 3.94390720 |
| 6 | Increased CSF lactate (HP:0002490) | 3.81045784 |
| 7 | Congenital stationary night blindness (HP:0007642) | 3.77921872 |
| 8 | IgG deficiency (HP:0004315) | 3.70328963 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.60842691 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.47969426 |
| 11 | Hepatic necrosis (HP:0002605) | 3.32926283 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.26210640 |
| 13 | Congenital, generalized hypertrichosis (HP:0004540) | 3.25790995 |
| 14 | Pancreatic cysts (HP:0001737) | 3.15084550 |
| 15 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.07425503 |
| 16 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.94065485 |
| 17 | Molar tooth sign on MRI (HP:0002419) | 2.93202182 |
| 18 | Abnormality of midbrain morphology (HP:0002418) | 2.93202182 |
| 19 | Cerebral edema (HP:0002181) | 2.84017231 |
| 20 | Abolished electroretinogram (ERG) (HP:0000550) | 2.69281313 |
| 21 | Nephronophthisis (HP:0000090) | 2.66114227 |
| 22 | Optic disc pallor (HP:0000543) | 2.62211216 |
| 23 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.59943721 |
| 24 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.59755383 |
| 25 | Methylmalonic acidemia (HP:0002912) | 2.58419040 |
| 26 | Attenuation of retinal blood vessels (HP:0007843) | 2.55770068 |
| 27 | T lymphocytopenia (HP:0005403) | 2.54675061 |
| 28 | Sclerocornea (HP:0000647) | 2.48941683 |
| 29 | Abnormality of the prostate (HP:0008775) | 2.48785705 |
| 30 | Renal Fanconi syndrome (HP:0001994) | 2.46003578 |
| 31 | Aplastic anemia (HP:0001915) | 2.43840768 |
| 32 | Increased serum lactate (HP:0002151) | 2.42911370 |
| 33 | Hypoplasia of the pons (HP:0012110) | 2.42409672 |
| 34 | Abnormality of the pons (HP:0007361) | 2.40088903 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.37570733 |
| 36 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.35527751 |
| 37 | Recurrent cutaneous fungal infections (HP:0011370) | 2.35527751 |
| 38 | Abnormality of T cell number (HP:0011839) | 2.35240607 |
| 39 | Abnormality of macular pigmentation (HP:0008002) | 2.34785770 |
| 40 | Type I transferrin isoform profile (HP:0003642) | 2.34212720 |
| 41 | Increased intramyocellular lipid droplets (HP:0012240) | 2.33540194 |
| 42 | Leukodystrophy (HP:0002415) | 2.33402728 |
| 43 | Exertional dyspnea (HP:0002875) | 2.31176622 |
| 44 | Stomatitis (HP:0010280) | 2.29837273 |
| 45 | Type II lissencephaly (HP:0007260) | 2.29723193 |
| 46 | Hypoplasia of the uterus (HP:0000013) | 2.28944981 |
| 47 | Pancreatic fibrosis (HP:0100732) | 2.27695047 |
| 48 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.27061866 |
| 49 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.27061866 |
| 50 | Hypothermia (HP:0002045) | 2.22049248 |
| 51 | True hermaphroditism (HP:0010459) | 2.22038781 |
| 52 | 3-Methylglutaconic aciduria (HP:0003535) | 2.21581090 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.18909830 |
| 54 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.18395375 |
| 55 | Methylmalonic aciduria (HP:0012120) | 2.15527823 |
| 56 | Respiratory failure (HP:0002878) | 2.15131670 |
| 57 | Lactic acidosis (HP:0003128) | 2.13709736 |
| 58 | Lethargy (HP:0001254) | 2.11526918 |
| 59 | Cerebral palsy (HP:0100021) | 2.07195872 |
| 60 | Abnormality of the renal medulla (HP:0100957) | 2.05052363 |
| 61 | Chronic hepatic failure (HP:0100626) | 2.04753671 |
| 62 | Constricted visual fields (HP:0001133) | 1.99072591 |
| 63 | Abnormality of T cells (HP:0002843) | 1.98550227 |
| 64 | Agammaglobulinemia (HP:0004432) | 1.98054133 |
| 65 | Pendular nystagmus (HP:0012043) | 1.95931593 |
| 66 | Delayed CNS myelination (HP:0002188) | 1.94506524 |
| 67 | Severe combined immunodeficiency (HP:0004430) | 1.87912030 |
| 68 | Hypoproteinemia (HP:0003075) | 1.87025644 |
| 69 | Abnormality of the renal cortex (HP:0011035) | 1.86339395 |
| 70 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.85354880 |
| 71 | Glycosuria (HP:0003076) | 1.84996130 |
| 72 | Abnormality of urine glucose concentration (HP:0011016) | 1.84996130 |
| 73 | Hemoptysis (HP:0002105) | 1.84150935 |
| 74 | Decreased central vision (HP:0007663) | 1.83713399 |
| 75 | Abnormality of methionine metabolism (HP:0010901) | 1.81599381 |
| 76 | Exercise intolerance (HP:0003546) | 1.81428342 |
| 77 | Concave nail (HP:0001598) | 1.76750282 |
| 78 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.76728758 |
| 79 | Metabolic alkalosis (HP:0200114) | 1.76718471 |
| 80 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.72010762 |
| 81 | Macrocytic anemia (HP:0001972) | 1.71882841 |
| 82 | Severe muscular hypotonia (HP:0006829) | 1.70847088 |
| 83 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 1.69190674 |
| 84 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.68048373 |
| 85 | Abnormal number of erythroid precursors (HP:0012131) | 1.67871874 |
| 86 | Chronic diarrhea (HP:0002028) | 1.66440237 |
| 87 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.66222651 |
| 88 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.64069552 |
| 89 | Asplenia (HP:0001746) | 1.63697446 |
| 90 | Male pseudohermaphroditism (HP:0000037) | 1.63448356 |
| 91 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.63133266 |
| 92 | Abnormality of alanine metabolism (HP:0010916) | 1.63133266 |
| 93 | Hyperalaninemia (HP:0003348) | 1.63133266 |
| 94 | Reticulocytopenia (HP:0001896) | 1.62551743 |
| 95 | Tongue fasciculations (HP:0001308) | 1.62424055 |
| 96 | Abnormal albumin level (HP:0012116) | 1.61692080 |
| 97 | Hypoalbuminemia (HP:0003073) | 1.61692080 |
| 98 | Homocystinuria (HP:0002156) | 1.61168705 |
| 99 | Abnormality of homocysteine metabolism (HP:0010919) | 1.61168705 |
| 100 | Thyroiditis (HP:0100646) | 1.60253661 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZAK | 3.92519613 |
| 2 | NUAK1 | 3.52592789 |
| 3 | TLK1 | 3.18618625 |
| 4 | VRK2 | 2.72286167 |
| 5 | ADRBK2 | 2.69087580 |
| 6 | GRK1 | 2.68153635 |
| 7 | MST4 | 2.48413148 |
| 8 | TXK | 2.45845331 |
| 9 | FRK | 2.42280881 |
| 10 | TEC | 2.19824876 |
| 11 | ITK | 2.16323201 |
| 12 | MAP4K2 | 2.13394061 |
| 13 | MAP4K1 | 1.84243614 |
| 14 | TAF1 | 1.74815942 |
| 15 | PIK3CA | 1.74216601 |
| 16 | EIF2AK3 | 1.67015814 |
| 17 | STK16 | 1.65537595 |
| 18 | VRK1 | 1.57114547 |
| 19 | BMPR2 | 1.53210810 |
| 20 | TAOK3 | 1.46539960 |
| 21 | KIT | 1.43398405 |
| 22 | TIE1 | 1.41670165 |
| 23 | TESK2 | 1.40220073 |
| 24 | WNK4 | 1.37372278 |
| 25 | CDK19 | 1.35817249 |
| 26 | MAP3K13 | 1.31870461 |
| 27 | PINK1 | 1.31086647 |
| 28 | IKBKB | 1.27427445 |
| 29 | NME1 | 1.26465538 |
| 30 | MAP2K6 | 1.23795289 |
| 31 | INSRR | 1.23789236 |
| 32 | NEK1 | 1.22533337 |
| 33 | MAPKAPK3 | 1.22013070 |
| 34 | ACVR1B | 1.19339595 |
| 35 | SYK | 1.18787729 |
| 36 | CSNK1G3 | 1.17438553 |
| 37 | FES | 1.16490172 |
| 38 | BMPR1B | 1.14280318 |
| 39 | CSNK1G2 | 1.13872565 |
| 40 | EIF2AK1 | 1.12427928 |
| 41 | BCKDK | 1.10104260 |
| 42 | DYRK2 | 1.09360781 |
| 43 | CSNK1G1 | 1.06528198 |
| 44 | MAP3K14 | 1.06373543 |
| 45 | DAPK1 | 1.02734846 |
| 46 | DAPK2 | 1.01199641 |
| 47 | TRIM28 | 0.93718624 |
| 48 | CSF1R | 0.90066257 |
| 49 | BUB1 | 0.89742676 |
| 50 | TNK2 | 0.88980563 |
| 51 | CSNK1A1L | 0.88648320 |
| 52 | FLT3 | 0.88195840 |
| 53 | PRKCE | 0.87071088 |
| 54 | PRKCQ | 0.86365852 |
| 55 | SRPK1 | 0.86221490 |
| 56 | NME2 | 0.84755024 |
| 57 | PLK3 | 0.83699271 |
| 58 | LYN | 0.83693518 |
| 59 | BTK | 0.83407619 |
| 60 | WNK3 | 0.80825995 |
| 61 | EIF2AK2 | 0.80520718 |
| 62 | KDR | 0.78869917 |
| 63 | MATK | 0.74231212 |
| 64 | RPS6KA5 | 0.74106258 |
| 65 | MKNK1 | 0.71253442 |
| 66 | RIPK4 | 0.70904674 |
| 67 | MAP3K4 | 0.70581310 |
| 68 | PHKG1 | 0.66717049 |
| 69 | PHKG2 | 0.66717049 |
| 70 | OXSR1 | 0.66115692 |
| 71 | MAPKAPK5 | 0.62460425 |
| 72 | TGFBR1 | 0.61784890 |
| 73 | MYLK | 0.61742754 |
| 74 | GRK6 | 0.60604596 |
| 75 | WEE1 | 0.59232924 |
| 76 | PIM1 | 0.57690579 |
| 77 | PASK | 0.56361214 |
| 78 | OBSCN | 0.55333065 |
| 79 | ADRBK1 | 0.54826845 |
| 80 | JAK3 | 0.53241273 |
| 81 | LCK | 0.52967942 |
| 82 | MAP3K12 | 0.51554039 |
| 83 | ILK | 0.51337312 |
| 84 | PRKCG | 0.48788090 |
| 85 | PDK2 | 0.48669275 |
| 86 | CAMK2D | 0.47703393 |
| 87 | PTK2B | 0.45781691 |
| 88 | IGF1R | 0.44045162 |
| 89 | GRK7 | 0.43426503 |
| 90 | STK38L | 0.43106062 |
| 91 | CSNK2A2 | 0.42335204 |
| 92 | PBK | 0.41847976 |
| 93 | DAPK3 | 0.41689042 |
| 94 | CSNK2A1 | 0.39891942 |
| 95 | MKNK2 | 0.39129138 |
| 96 | MAP2K2 | 0.38689781 |
| 97 | PRKACA | 0.38194259 |
| 98 | PRKCA | 0.37213955 |
| 99 | PLK2 | 0.36921949 |
| 100 | PRKG2 | 0.35559592 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Asthma_Homo sapiens_hsa05310 | 4.02369586 |
| 2 | Allograft rejection_Homo sapiens_hsa05330 | 3.60386159 |
| 3 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.37145325 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.33723248 |
| 5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.26828228 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.16343032 |
| 7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.12499878 |
| 8 | Protein export_Homo sapiens_hsa03060 | 3.06403223 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.90685636 |
| 10 | Proteasome_Homo sapiens_hsa03050 | 2.88706266 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 2.79975501 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.74148641 |
| 13 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.10178815 |
| 14 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.94320432 |
| 15 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.94235088 |
| 16 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.92737126 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 1.78541963 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.73428755 |
| 19 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.64200230 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.61715738 |
| 21 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.50733551 |
| 22 | Phototransduction_Homo sapiens_hsa04744 | 1.50509103 |
| 23 | Homologous recombination_Homo sapiens_hsa03440 | 1.49173378 |
| 24 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.49070167 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.48915887 |
| 26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.38254028 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.30968536 |
| 28 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.22423817 |
| 29 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.17820527 |
| 30 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.17404133 |
| 31 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.14553454 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.13485076 |
| 33 | Viral myocarditis_Homo sapiens_hsa05416 | 1.13318189 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.12665647 |
| 35 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.11857973 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.07893960 |
| 37 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.04242789 |
| 38 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.02499188 |
| 39 | Basal transcription factors_Homo sapiens_hsa03022 | 1.00563611 |
| 40 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.99383932 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 0.99114784 |
| 42 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.90802412 |
| 43 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.90761190 |
| 44 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.90712385 |
| 45 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.87983403 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.87010499 |
| 47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.82395606 |
| 48 | Leishmaniasis_Homo sapiens_hsa05140 | 0.80065807 |
| 49 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.79670557 |
| 50 | Spliceosome_Homo sapiens_hsa03040 | 0.76521379 |
| 51 | Mismatch repair_Homo sapiens_hsa03430 | 0.71174691 |
| 52 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.71021915 |
| 53 | RNA transport_Homo sapiens_hsa03013 | 0.68947772 |
| 54 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.68216022 |
| 55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.68144554 |
| 56 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.67763665 |
| 57 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.66930468 |
| 58 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.64059747 |
| 59 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.63203408 |
| 60 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.60378963 |
| 61 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.58570009 |
| 62 | Base excision repair_Homo sapiens_hsa03410 | 0.58392129 |
| 63 | Olfactory transduction_Homo sapiens_hsa04740 | 0.57171283 |
| 64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56214918 |
| 65 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.55436619 |
| 66 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.54271668 |
| 67 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50187497 |
| 68 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.50047842 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.49654185 |
| 70 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.49469775 |
| 71 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.48065440 |
| 72 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.47952637 |
| 73 | DNA replication_Homo sapiens_hsa03030 | 0.45102742 |
| 74 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.43150315 |
| 75 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41528044 |
| 76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.41457223 |
| 77 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.40303682 |
| 78 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39453952 |
| 79 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.37340788 |
| 80 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36717206 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.35967641 |
| 82 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.34850396 |
| 83 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.32313788 |
| 84 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.32306136 |
| 85 | Peroxisome_Homo sapiens_hsa04146 | 0.29105996 |
| 86 | Sulfur relay system_Homo sapiens_hsa04122 | 0.28607331 |
| 87 | Morphine addiction_Homo sapiens_hsa05032 | 0.24799741 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.24263977 |
| 89 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.24259776 |
| 90 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.23005707 |
| 91 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.21045533 |
| 92 | Salivary secretion_Homo sapiens_hsa04970 | 0.20625810 |
| 93 | Taste transduction_Homo sapiens_hsa04742 | 0.19920092 |
| 94 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.19766190 |
| 95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.18648920 |
| 96 | Nicotine addiction_Homo sapiens_hsa05033 | 0.18059491 |
| 97 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.16668434 |
| 98 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.15454366 |
| 99 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.14911016 |
| 100 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.14382476 |

