RPS3AP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61809774
2DNA deamination (GO:0045006)5.55166255
3ATP synthesis coupled proton transport (GO:0015986)5.12646459
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.12646459
5termination of RNA polymerase III transcription (GO:0006386)5.00803778
6transcription elongation from RNA polymerase III promoter (GO:0006385)5.00803778
7platelet dense granule organization (GO:0060155)4.68398108
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46434099
9cytidine deamination (GO:0009972)4.15969604
10cytidine metabolic process (GO:0046087)4.15969604
11cytidine catabolic process (GO:0006216)4.15969604
12respiratory electron transport chain (GO:0022904)4.09595146
13proteasome assembly (GO:0043248)4.07702010
14protein complex biogenesis (GO:0070271)4.04276056
15electron transport chain (GO:0022900)4.04265082
16protein neddylation (GO:0045116)3.89301306
17tryptophan catabolic process (GO:0006569)3.79807178
18indole-containing compound catabolic process (GO:0042436)3.79807178
19indolalkylamine catabolic process (GO:0046218)3.79807178
20NADH dehydrogenase complex assembly (GO:0010257)3.76131841
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76131841
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.76131841
23mitochondrial respiratory chain complex assembly (GO:0033108)3.66948834
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62557188
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57406071
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57406071
27ribosomal large subunit biogenesis (GO:0042273)3.55939826
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53143540
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51564513
30pyrimidine ribonucleoside catabolic process (GO:0046133)3.48611476
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.39634634
32ribosomal small subunit assembly (GO:0000028)3.31064373
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.29456792
34regulation of mitotic spindle checkpoint (GO:1903504)3.29456792
35tryptophan metabolic process (GO:0006568)3.20874659
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15253082
37cellular response to interferon-beta (GO:0035458)3.14828320
38kynurenine metabolic process (GO:0070189)3.12939871
39cotranslational protein targeting to membrane (GO:0006613)3.11762059
40viral transcription (GO:0019083)3.07822762
41protein targeting to ER (GO:0045047)3.07769178
42translational termination (GO:0006415)3.03693501
43L-fucose catabolic process (GO:0042355)3.02714358
44fucose catabolic process (GO:0019317)3.02714358
45L-fucose metabolic process (GO:0042354)3.02714358
46protein localization to endoplasmic reticulum (GO:0070972)3.02493254
47indolalkylamine metabolic process (GO:0006586)2.95649423
48establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91241580
49respiratory chain complex IV assembly (GO:0008535)2.91221213
50response to xenobiotic stimulus (GO:0009410)2.88234494
51translational elongation (GO:0006414)2.83067085
52translation (GO:0006412)2.82447629
53ATP biosynthetic process (GO:0006754)2.82395988
54behavioral response to nicotine (GO:0035095)2.81417448
55hydrogen ion transmembrane transport (GO:1902600)2.81182770
56maturation of 5.8S rRNA (GO:0000460)2.80268699
57response to interferon-beta (GO:0035456)2.80139028
58positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78698782
59proton transport (GO:0015992)2.77746393
60negative regulation of mast cell activation (GO:0033004)2.76373381
61hydrogen transport (GO:0006818)2.74683506
62purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74310364
63aldehyde catabolic process (GO:0046185)2.73443443
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73129822
65peptidyl-histidine modification (GO:0018202)2.72668773
66anterograde synaptic vesicle transport (GO:0048490)2.72643046
67axoneme assembly (GO:0035082)2.68930821
68regulation of chronic inflammatory response (GO:0002676)2.68652371
69cytochrome complex assembly (GO:0017004)2.68620549
70chaperone-mediated protein transport (GO:0072321)2.68408989
71cell wall macromolecule metabolic process (GO:0044036)2.67727662
72regulation of regulatory T cell differentiation (GO:0045589)2.65784437
73transcription from RNA polymerase III promoter (GO:0006383)2.65263386
74regulation of B cell receptor signaling pathway (GO:0050855)2.59672879
75regulation of cellular amino acid metabolic process (GO:0006521)2.58758967
76mitotic cell cycle arrest (GO:0071850)2.58316495
77water-soluble vitamin biosynthetic process (GO:0042364)2.57145532
78rRNA modification (GO:0000154)2.55140474
79regulation of isotype switching to IgG isotypes (GO:0048302)2.54562528
80positive regulation of protein homodimerization activity (GO:0090073)2.54279874
81inner mitochondrial membrane organization (GO:0007007)2.54150256
82transcription elongation from RNA polymerase I promoter (GO:0006362)2.53929541
83mannosylation (GO:0097502)2.53690555
84piRNA metabolic process (GO:0034587)2.53330841
85response to pheromone (GO:0019236)2.49779517
86detection of light stimulus involved in visual perception (GO:0050908)2.49082946
87detection of light stimulus involved in sensory perception (GO:0050962)2.49082946
88pseudouridine synthesis (GO:0001522)2.48412548
89cell wall macromolecule catabolic process (GO:0016998)2.48388507
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47523650
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47178355
92mast cell activation (GO:0045576)2.46039237
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45895911
94GPI anchor biosynthetic process (GO:0006506)2.44708059
95cellular response to interleukin-15 (GO:0071350)2.44204918
96GTP biosynthetic process (GO:0006183)2.43786964
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.43286825
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.43286825
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.43286825
100S-adenosylmethionine metabolic process (GO:0046500)2.42930925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.71300711
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56203079
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.51422314
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.29105897
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17243474
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.98635394
7VDR_22108803_ChIP-Seq_LS180_Human2.86272837
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.63888311
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61654574
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59314654
11VDR_23849224_ChIP-Seq_CD4+_Human2.43208143
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41584451
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25734215
14ZNF274_21170338_ChIP-Seq_K562_Hela2.25611383
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.20175828
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12592193
17FOXP3_21729870_ChIP-Seq_TREG_Human2.06003615
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05122118
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03748672
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.94341294
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92024889
22IGF1R_20145208_ChIP-Seq_DFB_Human1.91989797
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.85587749
24ELK1_19687146_ChIP-ChIP_HELA_Human1.81564992
25TP53_22573176_ChIP-Seq_HFKS_Human1.76516093
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74557543
27EWS_26573619_Chip-Seq_HEK293_Human1.74067405
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64458254
29TAF15_26573619_Chip-Seq_HEK293_Human1.59948198
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57843518
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57610375
32GATA3_26560356_Chip-Seq_TH2_Human1.57601513
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.53921828
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53921828
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.52449249
36MYC_18940864_ChIP-ChIP_HL60_Human1.46548404
37SOX2_19829295_ChIP-Seq_ESCs_Human1.44516467
38NANOG_19829295_ChIP-Seq_ESCs_Human1.44516467
39ER_23166858_ChIP-Seq_MCF-7_Human1.44170697
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.41669038
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39384383
42AR_20517297_ChIP-Seq_VCAP_Human1.39108733
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38868592
44FUS_26573619_Chip-Seq_HEK293_Human1.38206809
45P300_19829295_ChIP-Seq_ESCs_Human1.35996133
46IRF1_19129219_ChIP-ChIP_H3396_Human1.33858560
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32592173
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.29717893
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25566631
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25151104
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22186541
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20931825
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20367419
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19751517
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18753504
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17820654
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16731540
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.16644787
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14576579
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13682180
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12834242
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.12217705
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.11021142
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10739369
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10648072
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10466002
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.10057285
68TAF2_19829295_ChIP-Seq_ESCs_Human1.09989910
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09917134
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09769345
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08903553
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08487483
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.07907645
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07117674
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06608413
76BCAT_22108803_ChIP-Seq_LS180_Human1.05333627
77CBP_20019798_ChIP-Seq_JUKART_Human1.05208465
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05208465
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04385307
80NANOG_20526341_ChIP-Seq_ESCs_Human1.04355493
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03815429
82CDX2_22108803_ChIP-Seq_LS180_Human1.03289892
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01843237
84TTF2_22483619_ChIP-Seq_HELA_Human1.01080376
85GATA6_21074721_ChIP-Seq_CACO-2_Human1.00622349
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00145560
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00007354
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99612360
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99508760
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98571950
91HTT_18923047_ChIP-ChIP_STHdh_Human0.97966450
92MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97486464
93TCF4_22108803_ChIP-Seq_LS180_Human0.95229181
94GBX2_23144817_ChIP-Seq_PC3_Human0.94352284
95RBPJ_21746931_ChIP-Seq_IB4_Human0.92562350
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92233751
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92068124
98NCOR_22424771_ChIP-Seq_293T_Human0.91841076
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91183105
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90285699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19290363
2MP0003806_abnormal_nucleotide_metabolis3.30771543
3MP0005671_abnormal_response_to3.29454744
4MP0009379_abnormal_foot_pigmentation2.77009241
5MP0008875_abnormal_xenobiotic_pharmacok2.56718443
6MP0004147_increased_porphyrin_level2.44510806
7MP0009785_altered_susceptibility_to2.32171058
8MP0005360_urolithiasis2.25598880
9MP0005075_abnormal_melanosome_morpholog2.23467772
10MP0004145_abnormal_muscle_electrophysio2.20774637
11MP0002254_reproductive_system_inflammat2.19268111
12MP0004142_abnormal_muscle_tone2.17643817
13MP0002148_abnormal_hypersensitivity_rea2.14115746
14MP0002876_abnormal_thyroid_physiology2.12288163
15MP0006072_abnormal_retinal_apoptosis2.11252558
16MP0005377_hearing/vestibular/ear_phenot2.07285348
17MP0003878_abnormal_ear_physiology2.07285348
18MP0002837_dystrophic_cardiac_calcinosis1.97687083
19MP0000685_abnormal_immune_system1.96052555
20MP0001800_abnormal_humoral_immune1.92919314
21MP0002102_abnormal_ear_morphology1.83956573
22MP0005551_abnormal_eye_electrophysiolog1.81752830
23MP0005646_abnormal_pituitary_gland1.80915367
24MP0004885_abnormal_endolymph1.79801563
25MP0005387_immune_system_phenotype1.78098381
26MP0001790_abnormal_immune_system1.78098381
27MP0000372_irregular_coat_pigmentation1.77757385
28MP0008872_abnormal_physiological_respon1.74359385
29MP0006292_abnormal_olfactory_placode1.71101120
30MP0003011_delayed_dark_adaptation1.68626887
31MP0003195_calcinosis1.58113427
32MP0001501_abnormal_sleep_pattern1.56824027
33MP0002723_abnormal_immune_serum1.50944728
34MP0008877_abnormal_DNA_methylation1.48439724
35MP0005000_abnormal_immune_tolerance1.47047358
36MP0003786_premature_aging1.46443714
37MP0005645_abnormal_hypothalamus_physiol1.46223706
38MP0005253_abnormal_eye_physiology1.44925155
39MP0003186_abnormal_redox_activity1.38743999
40MP0002452_abnormal_antigen_presenting1.38217568
41MP0001968_abnormal_touch/_nociception1.38098630
42MP0003283_abnormal_digestive_organ1.33605734
43MP0006082_CNS_inflammation1.31647373
44MP0003866_abnormal_defecation1.30194694
45MP0002736_abnormal_nociception_after1.28792990
46MP0003718_maternal_effect1.28606644
47MP0001819_abnormal_immune_cell1.26332425
48MP0003646_muscle_fatigue1.25442038
49MP0009764_decreased_sensitivity_to1.24094148
50MP0002420_abnormal_adaptive_immunity1.22844831
51MP0002138_abnormal_hepatobiliary_system1.21230201
52MP0004043_abnormal_pH_regulation1.20876904
53MP0009333_abnormal_splenocyte_physiolog1.19073360
54MP0009697_abnormal_copulation1.18810947
55MP0005167_abnormal_blood-brain_barrier1.17736322
56MP0008995_early_reproductive_senescence1.15926265
57MP0006036_abnormal_mitochondrial_physio1.13280618
58MP0001919_abnormal_reproductive_system1.11920836
59MP0005025_abnormal_response_to1.11525640
60MP0005389_reproductive_system_phenotype1.11049370
61MP0003787_abnormal_imprinting1.10327681
62MP0009745_abnormal_behavioral_response1.07375328
63MP0010155_abnormal_intestine_physiology1.06520031
64MP0001905_abnormal_dopamine_level1.05640902
65MP0001873_stomach_inflammation1.05391118
66MP0001986_abnormal_taste_sensitivity1.04189924
67MP0001348_abnormal_lacrimal_gland1.03630096
68MP0002272_abnormal_nervous_system1.00884136
69MP0001764_abnormal_homeostasis1.00736695
70MP0002166_altered_tumor_susceptibility0.98945621
71MP0002277_abnormal_respiratory_mucosa0.96967921
72MP0002822_catalepsy0.96150954
73MP0003567_abnormal_fetal_cardiomyocyte0.95443309
74MP0003724_increased_susceptibility_to0.95061001
75MP0006035_abnormal_mitochondrial_morpho0.94630804
76MP0005379_endocrine/exocrine_gland_phen0.93119354
77MP0005636_abnormal_mineral_homeostasis0.92448624
78MP0000716_abnormal_immune_system0.87520189
79MP0002095_abnormal_skin_pigmentation0.85780921
80MP0003638_abnormal_response/metabolism_0.85744523
81MP0001845_abnormal_inflammatory_respons0.84961209
82MP0002006_tumorigenesis0.84786887
83MP0001970_abnormal_pain_threshold0.84335340
84MP0005332_abnormal_amino_acid0.83665906
85MP0002398_abnormal_bone_marrow0.82759729
86MP0003763_abnormal_thymus_physiology0.81905691
87MP0002139_abnormal_hepatobiliary_system0.80934848
88MP0000689_abnormal_spleen_morphology0.80127884
89MP0008469_abnormal_protein_level0.77932945
90MP0001440_abnormal_grooming_behavior0.77762758
91MP0001188_hyperpigmentation0.77198120
92MP0002733_abnormal_thermal_nociception0.77042450
93MP0003436_decreased_susceptibility_to0.76970071
94MP0001293_anophthalmia0.72379213
95MP0001853_heart_inflammation0.71980333
96MP0000631_abnormal_neuroendocrine_gland0.71508211
97MP0001529_abnormal_vocalization0.71041399
98MP0002163_abnormal_gland_morphology0.69717702
99MP0009046_muscle_twitch0.69515872
100MP0002735_abnormal_chemical_nociception0.69501994

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.67449518
2Acute encephalopathy (HP:0006846)4.09345136
3Abnormal mitochondria in muscle tissue (HP:0008316)4.06207073
4Mitochondrial inheritance (HP:0001427)4.02524767
5Progressive macrocephaly (HP:0004481)3.94390720
6Increased CSF lactate (HP:0002490)3.81045784
7Congenital stationary night blindness (HP:0007642)3.77921872
8IgG deficiency (HP:0004315)3.70328963
9Hepatocellular necrosis (HP:0001404)3.60842691
10Lipid accumulation in hepatocytes (HP:0006561)3.47969426
11Hepatic necrosis (HP:0002605)3.32926283
12Increased hepatocellular lipid droplets (HP:0006565)3.26210640
13Congenital, generalized hypertrichosis (HP:0004540)3.25790995
14Pancreatic cysts (HP:0001737)3.15084550
15Elevated erythrocyte sedimentation rate (HP:0003565)3.07425503
16Decreased electroretinogram (ERG) amplitude (HP:0000654)2.94065485
17Molar tooth sign on MRI (HP:0002419)2.93202182
18Abnormality of midbrain morphology (HP:0002418)2.93202182
19Cerebral edema (HP:0002181)2.84017231
20Abolished electroretinogram (ERG) (HP:0000550)2.69281313
21Nephronophthisis (HP:0000090)2.66114227
22Optic disc pallor (HP:0000543)2.62211216
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59943721
24Aplasia/hypoplasia of the uterus (HP:0008684)2.59755383
25Methylmalonic acidemia (HP:0002912)2.58419040
26Attenuation of retinal blood vessels (HP:0007843)2.55770068
27T lymphocytopenia (HP:0005403)2.54675061
28Sclerocornea (HP:0000647)2.48941683
29Abnormality of the prostate (HP:0008775)2.48785705
30Renal Fanconi syndrome (HP:0001994)2.46003578
31Aplastic anemia (HP:0001915)2.43840768
32Increased serum lactate (HP:0002151)2.42911370
33Hypoplasia of the pons (HP:0012110)2.42409672
34Abnormality of the pons (HP:0007361)2.40088903
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37570733
36Chronic mucocutaneous candidiasis (HP:0002728)2.35527751
37Recurrent cutaneous fungal infections (HP:0011370)2.35527751
38Abnormality of T cell number (HP:0011839)2.35240607
39Abnormality of macular pigmentation (HP:0008002)2.34785770
40Type I transferrin isoform profile (HP:0003642)2.34212720
41Increased intramyocellular lipid droplets (HP:0012240)2.33540194
42Leukodystrophy (HP:0002415)2.33402728
43Exertional dyspnea (HP:0002875)2.31176622
44Stomatitis (HP:0010280)2.29837273
45Type II lissencephaly (HP:0007260)2.29723193
46Hypoplasia of the uterus (HP:0000013)2.28944981
47Pancreatic fibrosis (HP:0100732)2.27695047
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27061866
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27061866
50Hypothermia (HP:0002045)2.22049248
51True hermaphroditism (HP:0010459)2.22038781
523-Methylglutaconic aciduria (HP:0003535)2.21581090
53Increased muscle lipid content (HP:0009058)2.18909830
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18395375
55Methylmalonic aciduria (HP:0012120)2.15527823
56Respiratory failure (HP:0002878)2.15131670
57Lactic acidosis (HP:0003128)2.13709736
58Lethargy (HP:0001254)2.11526918
59Cerebral palsy (HP:0100021)2.07195872
60Abnormality of the renal medulla (HP:0100957)2.05052363
61Chronic hepatic failure (HP:0100626)2.04753671
62Constricted visual fields (HP:0001133)1.99072591
63Abnormality of T cells (HP:0002843)1.98550227
64Agammaglobulinemia (HP:0004432)1.98054133
65Pendular nystagmus (HP:0012043)1.95931593
66Delayed CNS myelination (HP:0002188)1.94506524
67Severe combined immunodeficiency (HP:0004430)1.87912030
68Hypoproteinemia (HP:0003075)1.87025644
69Abnormality of the renal cortex (HP:0011035)1.86339395
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85354880
71Glycosuria (HP:0003076)1.84996130
72Abnormality of urine glucose concentration (HP:0011016)1.84996130
73Hemoptysis (HP:0002105)1.84150935
74Decreased central vision (HP:0007663)1.83713399
75Abnormality of methionine metabolism (HP:0010901)1.81599381
76Exercise intolerance (HP:0003546)1.81428342
77Concave nail (HP:0001598)1.76750282
78Abnormal rod and cone electroretinograms (HP:0008323)1.76728758
79Metabolic alkalosis (HP:0200114)1.76718471
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.72010762
81Macrocytic anemia (HP:0001972)1.71882841
82Severe muscular hypotonia (HP:0006829)1.70847088
83Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69190674
84Abnormal respiratory motile cilium physiology (HP:0012261)1.68048373
85Abnormal number of erythroid precursors (HP:0012131)1.67871874
86Chronic diarrhea (HP:0002028)1.66440237
87Abnormality of cells of the erythroid lineage (HP:0012130)1.66222651
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64069552
89Asplenia (HP:0001746)1.63697446
90Male pseudohermaphroditism (HP:0000037)1.63448356
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63133266
92Abnormality of alanine metabolism (HP:0010916)1.63133266
93Hyperalaninemia (HP:0003348)1.63133266
94Reticulocytopenia (HP:0001896)1.62551743
95Tongue fasciculations (HP:0001308)1.62424055
96Abnormal albumin level (HP:0012116)1.61692080
97Hypoalbuminemia (HP:0003073)1.61692080
98Homocystinuria (HP:0002156)1.61168705
99Abnormality of homocysteine metabolism (HP:0010919)1.61168705
100Thyroiditis (HP:0100646)1.60253661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.92519613
2NUAK13.52592789
3TLK13.18618625
4VRK22.72286167
5ADRBK22.69087580
6GRK12.68153635
7MST42.48413148
8TXK2.45845331
9FRK2.42280881
10TEC2.19824876
11ITK2.16323201
12MAP4K22.13394061
13MAP4K11.84243614
14TAF11.74815942
15PIK3CA1.74216601
16EIF2AK31.67015814
17STK161.65537595
18VRK11.57114547
19BMPR21.53210810
20TAOK31.46539960
21KIT1.43398405
22TIE11.41670165
23TESK21.40220073
24WNK41.37372278
25CDK191.35817249
26MAP3K131.31870461
27PINK11.31086647
28IKBKB1.27427445
29NME11.26465538
30MAP2K61.23795289
31INSRR1.23789236
32NEK11.22533337
33MAPKAPK31.22013070
34ACVR1B1.19339595
35SYK1.18787729
36CSNK1G31.17438553
37FES1.16490172
38BMPR1B1.14280318
39CSNK1G21.13872565
40EIF2AK11.12427928
41BCKDK1.10104260
42DYRK21.09360781
43CSNK1G11.06528198
44MAP3K141.06373543
45DAPK11.02734846
46DAPK21.01199641
47TRIM280.93718624
48CSF1R0.90066257
49BUB10.89742676
50TNK20.88980563
51CSNK1A1L0.88648320
52FLT30.88195840
53PRKCE0.87071088
54PRKCQ0.86365852
55SRPK10.86221490
56NME20.84755024
57PLK30.83699271
58LYN0.83693518
59BTK0.83407619
60WNK30.80825995
61EIF2AK20.80520718
62KDR0.78869917
63MATK0.74231212
64RPS6KA50.74106258
65MKNK10.71253442
66RIPK40.70904674
67MAP3K40.70581310
68PHKG10.66717049
69PHKG20.66717049
70OXSR10.66115692
71MAPKAPK50.62460425
72TGFBR10.61784890
73MYLK0.61742754
74GRK60.60604596
75WEE10.59232924
76PIM10.57690579
77PASK0.56361214
78OBSCN0.55333065
79ADRBK10.54826845
80JAK30.53241273
81LCK0.52967942
82MAP3K120.51554039
83ILK0.51337312
84PRKCG0.48788090
85PDK20.48669275
86CAMK2D0.47703393
87PTK2B0.45781691
88IGF1R0.44045162
89GRK70.43426503
90STK38L0.43106062
91CSNK2A20.42335204
92PBK0.41847976
93DAPK30.41689042
94CSNK2A10.39891942
95MKNK20.39129138
96MAP2K20.38689781
97PRKACA0.38194259
98PRKCA0.37213955
99PLK20.36921949
100PRKG20.35559592

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.02369586
2Allograft rejection_Homo sapiens_hsa053303.60386159
3Autoimmune thyroid disease_Homo sapiens_hsa053203.37145325
4Oxidative phosphorylation_Homo sapiens_hsa001903.33723248
5Graft-versus-host disease_Homo sapiens_hsa053323.26828228
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.16343032
7Type I diabetes mellitus_Homo sapiens_hsa049403.12499878
8Protein export_Homo sapiens_hsa030603.06403223
9RNA polymerase_Homo sapiens_hsa030202.90685636
10Proteasome_Homo sapiens_hsa030502.88706266
11Ribosome_Homo sapiens_hsa030102.79975501
12Parkinsons disease_Homo sapiens_hsa050122.74148641
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10178815
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94320432
15Antigen processing and presentation_Homo sapiens_hsa046121.94235088
16Primary immunodeficiency_Homo sapiens_hsa053401.92737126
17Alzheimers disease_Homo sapiens_hsa050101.78541963
18Huntingtons disease_Homo sapiens_hsa050161.73428755
19Linoleic acid metabolism_Homo sapiens_hsa005911.64200230
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61715738
21Rheumatoid arthritis_Homo sapiens_hsa053231.50733551
22Phototransduction_Homo sapiens_hsa047441.50509103
23Homologous recombination_Homo sapiens_hsa034401.49173378
24Cardiac muscle contraction_Homo sapiens_hsa042601.49070167
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48915887
26Caffeine metabolism_Homo sapiens_hsa002321.38254028
27RNA degradation_Homo sapiens_hsa030181.30968536
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22423817
29Regulation of autophagy_Homo sapiens_hsa041401.17820527
30Staphylococcus aureus infection_Homo sapiens_hsa051501.17404133
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14553454
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13485076
33Viral myocarditis_Homo sapiens_hsa054161.13318189
34One carbon pool by folate_Homo sapiens_hsa006701.12665647
35Pyrimidine metabolism_Homo sapiens_hsa002401.11857973
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07893960
37Nucleotide excision repair_Homo sapiens_hsa034201.04242789
38Tryptophan metabolism_Homo sapiens_hsa003801.02499188
39Basal transcription factors_Homo sapiens_hsa030221.00563611
40Hematopoietic cell lineage_Homo sapiens_hsa046400.99383932
41Purine metabolism_Homo sapiens_hsa002300.99114784
42Nitrogen metabolism_Homo sapiens_hsa009100.90802412
43Propanoate metabolism_Homo sapiens_hsa006400.90761190
44Chemical carcinogenesis_Homo sapiens_hsa052040.90712385
45Arachidonic acid metabolism_Homo sapiens_hsa005900.87983403
46Systemic lupus erythematosus_Homo sapiens_hsa053220.87010499
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82395606
48Leishmaniasis_Homo sapiens_hsa051400.80065807
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.79670557
50Spliceosome_Homo sapiens_hsa030400.76521379
51Mismatch repair_Homo sapiens_hsa034300.71174691
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71021915
53RNA transport_Homo sapiens_hsa030130.68947772
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68216022
55Fatty acid elongation_Homo sapiens_hsa000620.68144554
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67763665
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66930468
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64059747
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63203408
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60378963
61Butanoate metabolism_Homo sapiens_hsa006500.58570009
62Base excision repair_Homo sapiens_hsa034100.58392129
63Olfactory transduction_Homo sapiens_hsa047400.57171283
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56214918
65Ether lipid metabolism_Homo sapiens_hsa005650.55436619
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.54271668
67African trypanosomiasis_Homo sapiens_hsa051430.50187497
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.50047842
69Metabolic pathways_Homo sapiens_hsa011000.49654185
70Vitamin digestion and absorption_Homo sapiens_hsa049770.49469775
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.48065440
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.47952637
73DNA replication_Homo sapiens_hsa030300.45102742
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43150315
75Retinol metabolism_Homo sapiens_hsa008300.41528044
76Epstein-Barr virus infection_Homo sapiens_hsa051690.41457223
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40303682
78Glutathione metabolism_Homo sapiens_hsa004800.39453952
79Folate biosynthesis_Homo sapiens_hsa007900.37340788
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.36717206
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35967641
82Herpes simplex infection_Homo sapiens_hsa051680.34850396
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32313788
84Sulfur metabolism_Homo sapiens_hsa009200.32306136
85Peroxisome_Homo sapiens_hsa041460.29105996
86Sulfur relay system_Homo sapiens_hsa041220.28607331
87Morphine addiction_Homo sapiens_hsa050320.24799741
88Selenocompound metabolism_Homo sapiens_hsa004500.24263977
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24259776
90Serotonergic synapse_Homo sapiens_hsa047260.23005707
91Fanconi anemia pathway_Homo sapiens_hsa034600.21045533
92Salivary secretion_Homo sapiens_hsa049700.20625810
93Taste transduction_Homo sapiens_hsa047420.19920092
94Ovarian steroidogenesis_Homo sapiens_hsa049130.19766190
95Collecting duct acid secretion_Homo sapiens_hsa049660.18648920
96Nicotine addiction_Homo sapiens_hsa050330.18059491
97Fatty acid metabolism_Homo sapiens_hsa012120.16668434
98Fat digestion and absorption_Homo sapiens_hsa049750.15454366
99Fatty acid biosynthesis_Homo sapiens_hsa000610.14911016
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.14382476

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