ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of fever generation (GO:0031620)	8.74386245
2	positive regulation of heat generation (GO:0031652)	8.74001657
3	regulation of interleukin-12 biosynthetic process (GO:0045075)	8.71303111
4	regulation of prostaglandin secretion (GO:0032306)	8.67134651
5	positive regulation of T cell cytokine production (GO:0002726)	7.00207272
6	regulation of immunoglobulin secretion (GO:0051023)	6.95470321
7	regulation of heat generation (GO:0031650)	6.85379473
8	positive regulation of icosanoid secretion (GO:0032305)	6.77684406
9	positive regulation of osteoclast differentiation (GO:0045672)	6.65146110
10	positive regulation of transcription regulatory region DNA binding (GO:2000679)	6.51590945
11	bone resorption (GO:0045453)	6.34753053
12	positive regulation of fatty acid transport (GO:2000193)	6.23484939
13	positive regulation of bone remodeling (GO:0046852)	6.02660323
14	positive regulation of bone resorption (GO:0045780)	6.02660323
15	toxin transport (GO:1901998)	5.56380202
16	mammary gland epithelial cell proliferation (GO:0033598)	5.39803256
17	regulation of mitotic spindle checkpoint (GO:1903504)	5.27720613
18	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	5.27720613
19	response to lipoprotein particle (GO:0055094)	5.24531673
20	phospholipid homeostasis (GO:0055091)	5.16062820
21	T-helper 1 type immune response (GO:0042088)	5.11451653
22	regulation of icosanoid secretion (GO:0032303)	5.09407888
23	amyloid precursor protein catabolic process (GO:0042987)	4.99570376
24	galactose catabolic process (GO:0019388)	4.91597150
25	mammary gland alveolus development (GO:0060749)	4.88961010
26	peptidyl-threonine dephosphorylation (GO:0035970)	4.85129355
27	regulation of cholesterol esterification (GO:0010872)	4.83305337
28	regulation of skeletal muscle cell differentiation (GO:2001014)	4.79907058
29	sulfation (GO:0051923)	4.65591519
30	regulation of male gonad development (GO:2000018)	4.57300866
31	regulation of T cell cytokine production (GO:0002724)	4.55636416
32	protein-cofactor linkage (GO:0018065)	4.47502360
33	low-density lipoprotein particle remodeling (GO:0034374)	4.40118695
34	endoderm formation (GO:0001706)	4.30347932
35	tumor necrosis factor-mediated signaling pathway (GO:0033209)	4.24421222
36	positive regulation of organic acid transport (GO:0032892)	4.23844577
37	osteoclast differentiation (GO:0030316)	4.09839070
38	monocyte chemotaxis (GO:0002548)	4.09161363
39	regulation of homotypic cell-cell adhesion (GO:0034110)	4.04236073
40	mitotic cell cycle arrest (GO:0071850)	3.91086359
41	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.84661732
42	phospholipid efflux (GO:0033700)	3.81140583
43	regulation of chronic inflammatory response (GO:0002676)	3.79796095
44	activation of NF-kappaB-inducing kinase activity (GO:0007250)	3.78605363
45	actin nucleation (GO:0045010)	3.78510093
46	ERK1 and ERK2 cascade (GO:0070371)	3.75604638
47	positive regulation of sterol transport (GO:0032373)	3.57700664
48	positive regulation of cholesterol transport (GO:0032376)	3.57700664
49	branched-chain amino acid catabolic process (GO:0009083)	3.47763324
50	regulation of interleukin-6 biosynthetic process (GO:0045408)	3.44177307
51	cellular response to interleukin-1 (GO:0071347)	3.43970962
52	outer ear morphogenesis (GO:0042473)	3.43364163
53	high-density lipoprotein particle remodeling (GO:0034375)	3.43348168
54	protein deneddylation (GO:0000338)	3.42616563
55	cullin deneddylation (GO:0010388)	3.40170282
56	positive regulation of interleukin-12 production (GO:0032735)	3.36682903
57	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.21941979
58	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.21747153
59	regulation of energy homeostasis (GO:2000505)	3.19827991
60	CENP-A containing nucleosome assembly (GO:0034080)	3.16959426
61	positive regulation of cholesterol efflux (GO:0010875)	3.14324115
62	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.13148688
63	germ cell migration (GO:0008354)	3.12925555
64	response to UV-C (GO:0010225)	3.11255625
65	chromatin remodeling at centromere (GO:0031055)	3.08900725
66	folic acid-containing compound biosynthetic process (GO:0009396)	3.07965310
67	dendritic cell chemotaxis (GO:0002407)	3.07148160
68	negative regulation of meiotic cell cycle (GO:0051447)	3.05197265
69	somite rostral/caudal axis specification (GO:0032525)	3.03258028
70	protein polyglutamylation (GO:0018095)	3.02716359
71	positive regulation of myeloid leukocyte differentiation (GO:0002763)	2.99247892
72	regulation of cholesterol storage (GO:0010885)	2.95806489
73	branched-chain amino acid metabolic process (GO:0009081)	2.94301887
74	cellular ketone body metabolic process (GO:0046950)	2.92980840
75	positive regulation of NIK/NF-kappaB signaling (GO:1901224)	2.92830885
76	fucose catabolic process (GO:0019317)	2.91632031
77	L-fucose metabolic process (GO:0042354)	2.91632031
78	L-fucose catabolic process (GO:0042355)	2.91632031
79	positive regulation of tissue remodeling (GO:0034105)	2.89445814
80	viral protein processing (GO:0019082)	2.89323094
81	positive regulation of lipid transport (GO:0032370)	2.89189380
82	reverse cholesterol transport (GO:0043691)	2.88327634
83	intracellular lipid transport (GO:0032365)	2.87361197
84	signal transduction involved in regulation of gene expression (GO:0023019)	2.86354929
85	regulation of fatty acid transport (GO:2000191)	2.85798634
86	myeloid dendritic cell differentiation (GO:0043011)	2.84599143
87	amyloid precursor protein metabolic process (GO:0042982)	2.83828340
88	lymph node development (GO:0048535)	2.83563702
89	positive regulation of T cell mediated immunity (GO:0002711)	2.83262696
90	histone exchange (GO:0043486)	2.81608243
91	indolalkylamine metabolic process (GO:0006586)	2.81478130
92	regulation of cholesterol biosynthetic process (GO:0045540)	2.77796387
93	seminiferous tubule development (GO:0072520)	2.77608616
94	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.74943784
95	regulation of transcription regulatory region DNA binding (GO:2000677)	2.72369315
96	membrane protein intracellular domain proteolysis (GO:0031293)	2.71990560
97	positive regulation of acute inflammatory response (GO:0002675)	2.71874147
98	telomere maintenance via telomerase (GO:0007004)	2.69594749
99	interleukin-1-mediated signaling pathway (GO:0070498)	11.3514625
100	positive regulation of prostaglandin secretion (GO:0032308)	10.1073325

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.75711488
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.29592491
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.14564822
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.10203696
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.09312041
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.92278366
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85435493
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.51840208
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45263066
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.41266889
11	VDR_22108803_ChIP-Seq_LS180_Human	2.39806551
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.31682842
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30463739
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.29408877
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28121622
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.23481336
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14599545
18	EGR1_19032775_ChIP-ChIP_M12_Human	2.07100264
19	EWS_26573619_Chip-Seq_HEK293_Human	1.98123436
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.92989175
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.86331380
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.82278994
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.79176643
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.76128455
25	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.75283242
26	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.74572584
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68263868
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.68263868
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66652866
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.64909334
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56123047
32	FUS_26573619_Chip-Seq_HEK293_Human	1.49364705
33	E2F7_22180533_ChIP-Seq_HELA_Human	1.49280764
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.48954291
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.48954291
36	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.43540828
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.40708555
38	GATA3_26560356_Chip-Seq_TH2_Human	1.40259844
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.39221542
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36506379
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36186216
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.31246860
43	RUNX_20019798_ChIP-Seq_JUKART_Human	1.30833055
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30304871
45	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.29957715
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28788746
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26286160
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24704868
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.24371456
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23138989
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22937041
52	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.21634308
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.20020297
54	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.17730019
55	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16396716
56	P300_19829295_ChIP-Seq_ESCs_Human	1.16056337
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14954189
58	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.13753890
59	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.13292655
60	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.13292655
61	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.13292655
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12915441
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12598660
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12013851
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11944014
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10204468
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09917136
68	CEBPB_22108803_ChIP-Seq_LS180_Human	1.09734611
69	AR_20517297_ChIP-Seq_VCAP_Human	1.09385161
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09187272
71	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.09157150
72	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.09129089
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08498780
74	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.07363373
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05145607
76	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04675824
77	P300_18555785_Chip-Seq_ESCs_Mouse	1.04646998
78	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.04080607
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.04044304
80	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.02372638
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00820021
82	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00039527
83	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.99654208
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97416566
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97416566
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96881157
87	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.96864386
88	TP53_22573176_ChIP-Seq_HFKS_Human	0.96200985
89	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95666242
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94696367
91	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93794343
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93527992
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.92938389
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92688372
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92231405
96	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.91689629
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.91242165
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.90412120
99	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.90361129
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.90003489

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	4.66226391
2	MP0003436_decreased_susceptibility_to	4.57752272
3	MP0000685_abnormal_immune_system	4.44973911
4	MP0003191_abnormal_cellular_cholesterol	4.29146880
5	MP0003724_increased_susceptibility_to	4.08497405
6	MP0004782_abnormal_surfactant_physiolog	3.36176197
7	MP0005187_abnormal_penis_morphology	3.22882190
8	MP0003195_calcinosis	3.12316752
9	MP0002148_abnormal_hypersensitivity_rea	2.90872970
10	MP0004885_abnormal_endolymph	2.77210741
11	MP0009384_cardiac_valve_regurgitation	2.71522738
12	MP0002095_abnormal_skin_pigmentation	2.64797834
13	MP0002405_respiratory_system_inflammati	2.60598126
14	MP0001533_abnormal_skeleton_physiology	2.31545315
15	MP0002234_abnormal_pharynx_morphology	2.23600969
16	MP0002102_abnormal_ear_morphology	2.02710354
17	MP0003828_pulmonary_edema	1.79365199
18	MP0000538_abnormal_urinary_bladder	1.78741189
19	MP0003890_abnormal_embryonic-extraembry	1.74922618
20	MP0001790_abnormal_immune_system	1.70111849
21	MP0005387_immune_system_phenotype	1.70111849
22	MP0001881_abnormal_mammary_gland	1.66012902
23	MP0001984_abnormal_olfaction	1.64055045
24	MP0005671_abnormal_response_to	1.63986389
25	MP0008789_abnormal_olfactory_epithelium	1.60841112
26	MP0003183_abnormal_peptide_metabolism	1.60580990
27	MP0000647_abnormal_sebaceous_gland	1.50280103
28	MP0005535_abnormal_body_temperature	1.49833929
29	MP0004145_abnormal_muscle_electrophysio	1.49329366
30	MP0008875_abnormal_xenobiotic_pharmacok	1.48633596
31	MP0005448_abnormal_energy_balance	1.47932772
32	MP0005058_abnormal_lysosome_morphology	1.43972380
33	MP0000569_abnormal_digit_pigmentation	1.43427245
34	MP0004742_abnormal_vestibular_system	1.42538415
35	MP0005000_abnormal_immune_tolerance	1.42200045
36	MP0003119_abnormal_digestive_system	1.40276604
37	MP0001800_abnormal_humoral_immune	1.39871252
38	MP0008775_abnormal_heart_ventricle	1.39320064
39	MP0002723_abnormal_immune_serum	1.34893388
40	MP0003878_abnormal_ear_physiology	1.34727057
41	MP0005377_hearing/vestibular/ear_phenot	1.34727057
42	MP0002736_abnormal_nociception_after	1.30595701
43	MP0001968_abnormal_touch/_nociception	1.23784315
44	MP0001502_abnormal_circadian_rhythm	1.17077751
45	MP0002419_abnormal_innate_immunity	1.16128866
46	MP0004947_skin_inflammation	1.15832650
47	MP0001501_abnormal_sleep_pattern	1.12972524
48	MP0005394_taste/olfaction_phenotype	1.11821923
49	MP0005499_abnormal_olfactory_system	1.11821923
50	MP0006292_abnormal_olfactory_placode	1.11563315
51	MP0009785_altered_susceptibility_to	1.10149283
52	MP0002998_abnormal_bone_remodeling	1.06935321
53	MP0002452_abnormal_antigen_presenting	1.06380973
54	MP0009115_abnormal_fat_cell	1.05880233
55	MP0000427_abnormal_hair_cycle	1.03557164
56	MP0004133_heterotaxia	1.03063410
57	MP0003936_abnormal_reproductive_system	1.01657280
58	MP0001764_abnormal_homeostasis	1.01318971
59	MP0004142_abnormal_muscle_tone	0.97841436
60	MP0000689_abnormal_spleen_morphology	0.97479763
61	MP0000049_abnormal_middle_ear	0.93888721
62	MP0001835_abnormal_antigen_presentation	0.93053123
63	MP0002111_abnormal_tail_morphology	0.92879309
64	MP0009250_abnormal_appendicular_skeleto	0.92490103
65	MP0002398_abnormal_bone_marrow	0.92439596
66	MP0005551_abnormal_eye_electrophysiolog	0.91428089
67	MP0001293_anophthalmia	0.91368895
68	MP0002420_abnormal_adaptive_immunity	0.88588484
69	MP0001819_abnormal_immune_cell	0.87747383
70	MP0008872_abnormal_physiological_respon	0.87280388
71	MP0000703_abnormal_thymus_morphology	0.85954202
72	MP0000716_abnormal_immune_system	0.83384742
73	MP0003959_abnormal_lean_body	0.83274247
74	MP0009764_decreased_sensitivity_to	0.82332588
75	MP0005389_reproductive_system_phenotype	0.82107848
76	MP0005075_abnormal_melanosome_morpholog	0.81641107
77	MP0002837_dystrophic_cardiac_calcinosis	0.81500909
78	MP0005390_skeleton_phenotype	0.80300984
79	MP0002722_abnormal_immune_system	0.79314223
80	MP0002971_abnormal_brown_adipose	0.79110470
81	MP0003937_abnormal_limbs/digits/tail_de	0.76689414
82	MP0002160_abnormal_reproductive_system	0.75092602
83	MP0010771_integument_phenotype	0.74190539
84	MP0002127_abnormal_cardiovascular_syste	0.73959782
85	MP0002060_abnormal_skin_morphology	0.72960969
86	MP0008770_decreased_survivor_rate	0.70023082
87	MP0006072_abnormal_retinal_apoptosis	0.69268489
88	MP0000639_abnormal_adrenal_gland	0.68080641
89	MP0004957_abnormal_blastocyst_morpholog	0.67616490
90	MP0000230_abnormal_systemic_arterial	0.67320364
91	MP0005174_abnormal_tail_pigmentation	0.66484986
92	MP0000627_abnormal_mammary_gland	0.65938477
93	MP0005423_abnormal_somatic_nervous	0.65370636
94	MP0008057_abnormal_DNA_replication	0.65352486
95	MP0002098_abnormal_vibrissa_morphology	0.65011153
96	MP0002932_abnormal_joint_morphology	0.63793255
97	MP0005636_abnormal_mineral_homeostasis	0.63247415
98	MP0001919_abnormal_reproductive_system	0.63114154
99	MP0002177_abnormal_outer_ear	0.62121748
100	MP0003567_abnormal_fetal_cardiomyocyte	0.61679420

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased density of long bones (HP:0006392)	8.89540409
2	Premature loss of primary teeth (HP:0006323)	8.32233882
3	Persistence of primary teeth (HP:0006335)	7.76025959
4	Asymmetric septal hypertrophy (HP:0001670)	5.14500085
5	Mucopolysacchariduria (HP:0008155)	4.58398242
6	Urinary glycosaminoglycan excretion (HP:0003541)	4.58398242
7	Dysostosis multiplex (HP:0000943)	4.20926161
8	Abnormality of mucopolysaccharide metabolism (HP:0011020)	4.18809007
9	Abnormality of polysaccharide metabolism (HP:0011012)	4.18809007
10	Abnormality of glycosaminoglycan metabolism (HP:0004371)	4.18809007
11	Rhinitis (HP:0012384)	4.18248052
12	Type II lissencephaly (HP:0007260)	4.09628835
13	Chronic hepatic failure (HP:0100626)	4.05718117
14	Periodontitis (HP:0000704)	4.01929459
15	Retinal dysplasia (HP:0007973)	3.89433982
16	Malignant hyperthermia (HP:0002047)	3.80892928
17	Joint stiffness (HP:0001387)	3.73576705
18	Infantile muscular hypotonia (HP:0008947)	3.68216766
19	Cerebellar dysplasia (HP:0007033)	3.67021255
20	Abnormality of primary teeth (HP:0006481)	3.53829316
21	Sensorimotor neuropathy (HP:0007141)	3.47895305
22	3-Methylglutaconic aciduria (HP:0003535)	3.45612154
23	Increased hepatocellular lipid droplets (HP:0006565)	3.42728826
24	Abnormality of DNA repair (HP:0003254)	3.42591040
25	Ovoid vertebral bodies (HP:0003300)	3.42277730
26	Severe combined immunodeficiency (HP:0004430)	3.32982292
27	Thyroiditis (HP:0100646)	3.24577463
28	Abnormality of the labia minora (HP:0012880)	3.10329392
29	Lipid accumulation in hepatocytes (HP:0006561)	2.94132792
30	Back pain (HP:0003418)	2.89361226
31	Vacuolated lymphocytes (HP:0001922)	2.81042584
32	Agammaglobulinemia (HP:0004432)	2.75578494
33	Abnormal number of erythroid precursors (HP:0012131)	2.75167024
34	Lissencephaly (HP:0001339)	2.75039310
35	Hepatosplenomegaly (HP:0001433)	2.71963154
36	Pancytopenia (HP:0001876)	2.69670983
37	Attenuation of retinal blood vessels (HP:0007843)	2.64266138
38	Loss of speech (HP:0002371)	2.62967971
39	Flared iliac wings (HP:0002869)	2.59306164
40	Combined immunodeficiency (HP:0005387)	2.57188023
41	Metabolic alkalosis (HP:0200114)	2.54758335
42	Rib fusion (HP:0000902)	2.45373990
43	Abnormality of cells of the erythroid lineage (HP:0012130)	2.40205844
44	Hypophosphatemia (HP:0002148)	2.38457898
45	Tubulointerstitial fibrosis (HP:0005576)	2.35738419
46	Hypoplasia of the thymus (HP:0000778)	2.34031857
47	Abnormality of the costochondral junction (HP:0000919)	2.33644487
48	Pulmonary infiltrates (HP:0002113)	2.31224041
49	Renal Fanconi syndrome (HP:0001994)	2.31098804
50	Ulnar deviation of the wrist (HP:0003049)	2.24980424
51	Abnormality of skull ossification (HP:0002703)	2.23648271
52	Delusions (HP:0000746)	2.22548696
53	IgG deficiency (HP:0004315)	2.20055384
54	Gonadal dysgenesis (HP:0000133)	2.18991059
55	Hypocalcemia (HP:0002901)	2.17120758
56	Hypertensive crisis (HP:0100735)	2.16764776
57	Hypokalemic alkalosis (HP:0001949)	2.14980206
58	Submucous cleft hard palate (HP:0000176)	2.08616551
59	Pallor (HP:0000980)	2.06881667
60	Abnormality of eosinophils (HP:0001879)	2.03891020
61	Pancreatic cysts (HP:0001737)	2.02385525
62	Disproportionate short-trunk short stature (HP:0003521)	2.02228822
63	Congenital, generalized hypertrichosis (HP:0004540)	2.01026614
64	Respiratory difficulties (HP:0002880)	1.89390764
65	Severe short stature (HP:0003510)	1.87217769
66	Renal salt wasting (HP:0000127)	1.85216765
67	Premature ovarian failure (HP:0008209)	1.83848880
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83008091
69	Abnormality of the parathyroid morphology (HP:0011766)	1.80771079
70	Pulmonary fibrosis (HP:0002206)	1.80557429
71	Cervical subluxation (HP:0003308)	1.78367426
72	CNS hypomyelination (HP:0003429)	1.77767259
73	Recurrent bronchitis (HP:0002837)	1.76944263
74	Enlarged epiphyses (HP:0010580)	1.75763707
75	Tetany (HP:0001281)	1.73480613
76	Chronic mucocutaneous candidiasis (HP:0002728)	1.72314352
77	Recurrent cutaneous fungal infections (HP:0011370)	1.72314352
78	Optic neuritis (HP:0100653)	1.71772233
79	Retrobulbar optic neuritis (HP:0100654)	1.71772233
80	Hyperaldosteronism (HP:0000859)	1.71269507
81	Chronic diarrhea (HP:0002028)	1.71150000
82	True hermaphroditism (HP:0010459)	1.70578436
83	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.69111753
84	Rimmed vacuoles (HP:0003805)	1.68379268
85	Delayed epiphyseal ossification (HP:0002663)	1.67529354
86	Increased intramyocellular lipid droplets (HP:0012240)	1.66431635
87	Azoospermia (HP:0000027)	1.65556842
88	Exertional dyspnea (HP:0002875)	1.65295135
89	Abnormality of the renal medulla (HP:0100957)	1.62988191
90	Abnormality of vision evoked potentials (HP:0000649)	1.62587412
91	Polyuria (HP:0000103)	1.62370731
92	Abnormality of chloride homeostasis (HP:0011422)	1.61381174
93	Abnormality of T cell number (HP:0011839)	1.59805065
94	Abnormality of the aortic arch (HP:0012303)	1.58792990
95	Pancreatic fibrosis (HP:0100732)	1.55959124
96	Prominent metopic ridge (HP:0005487)	1.55091369
97	Alkalosis (HP:0001948)	1.53283246
98	Abnormality of the renal cortex (HP:0011035)	1.52990225
99	Wide cranial sutures (HP:0010537)	1.52864337
100	Cranial hyperostosis (HP:0004437)	1.52733535

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC42BPA	5.09411069
2	TESK2	5.07035172
3	BCKDK	4.69965063
4	MAP3K13	4.02148351
5	MAP2K2	3.81118957
6	TLK1	3.64495275
7	CDK8	2.69602767
8	TSSK6	2.27127445
9	ACVR1B	2.20993932
10	MAP2K6	2.00820665
11	EIF2AK3	1.94457051
12	TRIM28	1.84996524
13	GRK7	1.82952422
14	ADRBK2	1.79650280
15	FRK	1.78248146
16	TXK	1.67869356
17	MAP3K14	1.66070726
18	MKNK2	1.66057279
19	CASK	1.63070692
20	PLK4	1.61806088
21	MAP2K1	1.61499596
22	PDK2	1.59760196
23	ADRBK1	1.57342242
24	GRK6	1.56701010
25	NEK9	1.45682773
26	ALK	1.40640568
27	MAP3K4	1.40192764
28	EIF2AK1	1.37555780
29	MKNK1	1.36059705
30	FES	1.19895677
31	ERBB3	1.15461957
32	SRPK1	1.12403655
33	PAK3	1.10905657
34	NUAK1	1.09944241
35	WNK3	0.99752677
36	PNCK	0.97990196
37	WEE1	0.88744295
38	TGFBR2	0.86015811
39	STK3	0.85792357
40	TAF1	0.85016998
41	STK11	0.84456194
42	MAP3K7	0.75206386
43	MST4	0.72814248
44	PRKCI	0.72242343
45	CDK4	0.71646588
46	CDC7	0.69216593
47	EIF2AK2	0.65350987
48	DYRK2	0.61913515
49	ZAK	0.60824380
50	KIT	0.60208850
51	KDR	0.58923719
52	INSRR	0.57929130
53	BMPR1B	0.57616691
54	ATR	0.56912925
55	MARK1	0.55728270
56	MAP2K7	0.55494843
57	MAP4K2	0.54729219
58	PKN1	0.54059657
59	STK16	0.52747019
60	PBK	0.51829587
61	GRK1	0.50322346
62	ERBB4	0.49220299
63	PLK3	0.48901669
64	DYRK3	0.48234627
65	PRKCG	0.47646712
66	NLK	0.43815659
67	PIM1	0.41206153
68	AURKA	0.40971279
69	BLK	0.40789049
70	IKBKB	0.40426702
71	CHUK	0.40294173
72	SIK2	0.40022012
73	SYK	0.39579629
74	IGF1R	0.38703946
75	CAMKK2	0.37508646
76	CSNK2A2	0.36339735
77	PRKCD	0.36247937
78	GRK5	0.35910187
79	TAOK3	0.35831843
80	PRKACB	0.35771236
81	TTK	0.34151458
82	MATK	0.33572134
83	EPHA3	0.33443797
84	IKBKE	0.33272609
85	PRKDC	0.33165621
86	PRKCQ	0.33102507
87	LYN	0.32386178
88	STK38L	0.31311156
89	ITK	0.30415882
90	DAPK2	0.29666300
91	STK10	0.29534395
92	LCK	0.28982778
93	OXSR1	0.28343947
94	PRKCA	0.27024805
95	TGFBR1	0.25481303
96	CSNK1E	0.24390081
97	MELK	0.23194807
98	PAK1	0.21956599
99	CHEK1	0.21460199
100	RIPK4	0.19754913

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.48053818
2	Phenylalanine metabolism_Homo sapiens_hsa00360	3.02685250
3	Caffeine metabolism_Homo sapiens_hsa00232	2.81258662
4	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.48977804
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.46577707
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08623310
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	11.5027716
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.96287614
9	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77827644
10	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.75857689
11	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.70189743
12	One carbon pool by folate_Homo sapiens_hsa00670	1.62401247
13	Phototransduction_Homo sapiens_hsa04744	1.47013792
14	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.46537116
15	Tyrosine metabolism_Homo sapiens_hsa00350	1.30567458
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.27211307
17	Mismatch repair_Homo sapiens_hsa03430	1.25667958
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25008821
19	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.22541486
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22536530
21	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.16919513
22	Homologous recombination_Homo sapiens_hsa03440	1.13843612
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.12405526
24	ABC transporters_Homo sapiens_hsa02010	1.11618506
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.10741773
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09480153
27	RNA polymerase_Homo sapiens_hsa03020	1.06386420
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05729832
29	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.05408843
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97976729
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96012538
32	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94398194
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94312498
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93837722
35	RNA degradation_Homo sapiens_hsa03018	0.93141522
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.91298761
37	DNA replication_Homo sapiens_hsa03030	0.87373096
38	Proteasome_Homo sapiens_hsa03050	0.86701634
39	Oxidative phosphorylation_Homo sapiens_hsa00190	0.76713771
40	Peroxisome_Homo sapiens_hsa04146	0.72490179
41	Purine metabolism_Homo sapiens_hsa00230	0.71948779
42	Pentose phosphate pathway_Homo sapiens_hsa00030	0.69615440
43	Basal transcription factors_Homo sapiens_hsa03022	0.69582158
44	Osteoclast differentiation_Homo sapiens_hsa04380	0.66184688
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61637111
46	Circadian rhythm_Homo sapiens_hsa04710	0.60668310
47	Butanoate metabolism_Homo sapiens_hsa00650	0.60641666
48	RNA transport_Homo sapiens_hsa03013	0.58693112
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.58197272
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56422370
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.55342749
52	Primary immunodeficiency_Homo sapiens_hsa05340	0.53736052
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53127162
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.49678539
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.49628867
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49500216
57	Galactose metabolism_Homo sapiens_hsa00052	0.46231630
58	Base excision repair_Homo sapiens_hsa03410	0.44968860
59	Parkinsons disease_Homo sapiens_hsa05012	0.44446629
60	Sulfur metabolism_Homo sapiens_hsa00920	0.44206444
61	Protein export_Homo sapiens_hsa03060	0.42563844
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.42355224
63	Ribosome_Homo sapiens_hsa03010	0.42131937
64	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.41628552
65	Propanoate metabolism_Homo sapiens_hsa00640	0.39422925
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35414271
67	Nicotine addiction_Homo sapiens_hsa05033	0.32687133
68	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31506632
69	Prolactin signaling pathway_Homo sapiens_hsa04917	0.26674376
70	Asthma_Homo sapiens_hsa05310	0.26411773
71	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.24879541
72	Herpes simplex infection_Homo sapiens_hsa05168	0.24025983
73	Pertussis_Homo sapiens_hsa05133	0.22196806
74	Metabolic pathways_Homo sapiens_hsa01100	0.21647383
75	Huntingtons disease_Homo sapiens_hsa05016	0.21274763
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.21098165
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.20834150
78	Taste transduction_Homo sapiens_hsa04742	0.20753808
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.20332406
80	Measles_Homo sapiens_hsa05162	0.20233944
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.19210445
82	MAPK signaling pathway_Homo sapiens_hsa04010	0.19130591
83	Lysosome_Homo sapiens_hsa04142	0.18427095
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.18041288
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.16074282
86	Retinol metabolism_Homo sapiens_hsa00830	0.15513737
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.15207823
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.14517104
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.14414145
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.13945128
91	Small cell lung cancer_Homo sapiens_hsa05222	0.13574134
92	Alzheimers disease_Homo sapiens_hsa05010	0.13527740
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.13166832
94	Morphine addiction_Homo sapiens_hsa05032	0.13163877
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.11857454
96	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.10861968
97	Cardiac muscle contraction_Homo sapiens_hsa04260	0.10840832
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.10530690
99	Leishmaniasis_Homo sapiens_hsa05140	0.10257983
100	Olfactory transduction_Homo sapiens_hsa04740	0.08050301

RPS3AP40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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