ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.94407868
2	DNA deamination (GO:0045006)	4.76823005
3	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.75691199
4	ribosomal large subunit biogenesis (GO:0042273)	4.46534165
5	positive regulation of B cell differentiation (GO:0045579)	4.42431661
6	viral transcription (GO:0019083)	4.12917287
7	cytidine metabolic process (GO:0046087)	3.96529658
8	cytidine catabolic process (GO:0006216)	3.96529658
9	cytidine deamination (GO:0009972)	3.96529658
10	translational termination (GO:0006415)	3.96384761
11	regulation of B cell receptor signaling pathway (GO:0050855)	3.87051329
12	negative regulation of T cell apoptotic process (GO:0070233)	3.79517926
13	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.75981120
14	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.64798562
15	translational elongation (GO:0006414)	3.64250277
16	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.57298002
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.48990029
18	mature B cell differentiation involved in immune response (GO:0002313)	3.45339067
19	cotranslational protein targeting to membrane (GO:0006613)	3.41158427
20	protein targeting to ER (GO:0045047)	3.38179864
21	actin nucleation (GO:0045010)	3.37110108
22	regulation of activation of Janus kinase activity (GO:0010533)	3.37070291
23	aggressive behavior (GO:0002118)	3.34430851
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.30310175
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.23696481
26	ATP synthesis coupled proton transport (GO:0015986)	3.23696481
27	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.21986498
28	regulation of alpha-beta T cell proliferation (GO:0046640)	3.21305818
29	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.20634100
30	protein localization to endoplasmic reticulum (GO:0070972)	3.19619419
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.19414330
32	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.18850655
33	positive thymic T cell selection (GO:0045059)	3.18592758
34	mature B cell differentiation (GO:0002335)	3.18001267
35	cell wall macromolecule metabolic process (GO:0044036)	3.14645985
36	negative regulation of heart rate (GO:0010459)	3.13207689
37	regulation of B cell differentiation (GO:0045577)	3.12838888
38	sequestering of actin monomers (GO:0042989)	3.10793899
39	purine deoxyribonucleotide catabolic process (GO:0009155)	3.09078332
40	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.03866267
41	positive T cell selection (GO:0043368)	3.03061744
42	detection of light stimulus involved in visual perception (GO:0050908)	2.99156814
43	detection of light stimulus involved in sensory perception (GO:0050962)	2.99156814
44	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.98059237
45	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.95522672
46	positive regulation of T cell differentiation in thymus (GO:0033089)	2.94490563
47	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.94163096
48	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.94162020
49	purine nucleotide salvage (GO:0032261)	2.90756573
50	viral life cycle (GO:0019058)	2.87724831
51	platelet dense granule organization (GO:0060155)	2.87071409
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86982254
53	forebrain morphogenesis (GO:0048853)	2.86215782
54	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.85213672
55	regulation of germinal center formation (GO:0002634)	2.84984796
56	positive regulation of interleukin-17 production (GO:0032740)	2.84885585
57	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84029327
58	positive regulation of granulocyte differentiation (GO:0030854)	2.83165220
59	regulation of regulatory T cell differentiation (GO:0045589)	2.82779351
60	cellular protein complex disassembly (GO:0043624)	2.81674708
61	regulation of T cell receptor signaling pathway (GO:0050856)	2.79757491
62	translational initiation (GO:0006413)	2.78782538
63	response to pheromone (GO:0019236)	2.77509662
64	immunoglobulin mediated immune response (GO:0016064)	2.76503971
65	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.75819988
66	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.75180931
67	regulation of T cell tolerance induction (GO:0002664)	2.74769625
68	T cell receptor signaling pathway (GO:0050852)	2.73197157
69	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.72972264
70	urate metabolic process (GO:0046415)	2.72239573
71	negative T cell selection (GO:0043383)	2.72185371
72	definitive hemopoiesis (GO:0060216)	2.72173781
73	regulation of T cell mediated cytotoxicity (GO:0001914)	2.70862283
74	regulation of action potential (GO:0098900)	2.70266056
75	T cell costimulation (GO:0031295)	2.69776239
76	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.67670104
77	lymphocyte costimulation (GO:0031294)	2.67058389
78	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.66506784
79	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.66113529
80	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.64882465
81	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.64230800
82	base-excision repair, AP site formation (GO:0006285)	2.62070681
83	positive regulation of gamma-delta T cell activation (GO:0046645)	2.59582666
84	antigen receptor-mediated signaling pathway (GO:0050851)	2.59329748
85	deoxyribonucleotide catabolic process (GO:0009264)	2.58040299
86	negative regulation of oxidoreductase activity (GO:0051354)	2.56933299
87	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.54136025
88	response to interferon-beta (GO:0035456)	2.54039725
89	iron-sulfur cluster assembly (GO:0016226)	2.53064411
90	metallo-sulfur cluster assembly (GO:0031163)	2.53064411
91	regulation of interleukin-17 production (GO:0032660)	2.52574908
92	pharyngeal system development (GO:0060037)	2.50809127
93	positive regulation of digestive system process (GO:0060456)	2.49567499
94	regulation of T cell apoptotic process (GO:0070232)	2.48269851
95	respiratory electron transport chain (GO:0022904)	2.48216097
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.48210165
97	positive regulation of tolerance induction (GO:0002645)	2.47534141
98	electron transport chain (GO:0022900)	2.47440556
99	deoxyribose phosphate catabolic process (GO:0046386)	2.46986324
100	positive regulation of interleukin-4 production (GO:0032753)	2.46923247

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.13957479
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.49456477
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.28405819
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.02919670
5	VDR_22108803_ChIP-Seq_LS180_Human	2.97488226
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.69146649
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.66825345
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.65395083
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.48639899
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.46689167
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.41482943
12	GATA1_22025678_ChIP-Seq_K562_Human	2.36071714
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.24154338
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.20254846
15	FUS_26573619_Chip-Seq_HEK293_Human	2.14760615
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.11268855
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.10831442
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09994904
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.09233487
20	EWS_26573619_Chip-Seq_HEK293_Human	2.07556018
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01608469
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.01457355
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93859589
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.88935226
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83930569
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.80385969
27	MYB_26560356_Chip-Seq_TH2_Human	1.75545517
28	RUNX_20019798_ChIP-Seq_JUKART_Human	1.64262442
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.62120815
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60610069
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56884240
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.55389352
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55091110
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54687449
35	SCL_19346495_ChIP-Seq_HPC-7_Human	1.53286050
36	P300_19829295_ChIP-Seq_ESCs_Human	1.51739873
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49307960
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49307960
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47310928
40	AR_20517297_ChIP-Seq_VCAP_Human	1.46707038
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.43079635
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42742210
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41122678
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41122678
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40932628
46	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.37449500
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36825538
48	GATA3_26560356_Chip-Seq_TH2_Human	1.36574039
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36113429
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.34599313
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.33282434
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33267856
53	GATA3_27048872_Chip-Seq_THYMUS_Human	1.29512757
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26110377
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25937687
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.25127462
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.25112262
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.23629409
59	NCOR_22424771_ChIP-Seq_293T_Human	1.23468819
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21128125
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20780943
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20669644
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19680428
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16805261
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15636564
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.15636564
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15479976
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13630904
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13325015
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12932898
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12598540
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11712730
73	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11330999
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10937071
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07721628
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07228999
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.05208045
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04328409
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.03061172
80	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02513481
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01923924
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01350541
83	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.99045555
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97354766
85	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97300537
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.96698850
87	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96605849
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95633178
89	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95419975
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93665750
91	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.93619381
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.93535726
93	FOXP3_21729870_ChIP-Seq_TREG_Human	0.93218064
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.92740515
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92359996
96	AR_25329375_ChIP-Seq_VCAP_Human	0.91836667
97	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91597312
98	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91180082
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90220130
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90024236

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.53666811
2	MP0009379_abnormal_foot_pigmentation	3.19849379
3	MP0001835_abnormal_antigen_presentation	3.18135427
4	MP0009785_altered_susceptibility_to	2.45347452
5	MP0003763_abnormal_thymus_physiology	2.31349605
6	MP0001873_stomach_inflammation	2.29983223
7	MP0002166_altered_tumor_susceptibility	2.20288078
8	MP0005646_abnormal_pituitary_gland	2.08729926
9	MP0005000_abnormal_immune_tolerance	2.05712476
10	MP0003806_abnormal_nucleotide_metabolis	2.02487766
11	MP0002138_abnormal_hepatobiliary_system	2.01762496
12	MP0002837_dystrophic_cardiac_calcinosis	2.01100046
13	MP0001800_abnormal_humoral_immune	2.01064003
14	MP0005645_abnormal_hypothalamus_physiol	1.96537316
15	MP0002148_abnormal_hypersensitivity_rea	1.94558301
16	MP0003646_muscle_fatigue	1.92433940
17	MP0006072_abnormal_retinal_apoptosis	1.89225273
18	MP0006292_abnormal_olfactory_placode	1.88377683
19	MP0001764_abnormal_homeostasis	1.76488779
20	MP0009333_abnormal_splenocyte_physiolog	1.76075374
21	MP0002102_abnormal_ear_morphology	1.74044323
22	MP0004147_increased_porphyrin_level	1.71151263
23	MP0008872_abnormal_physiological_respon	1.70742702
24	MP0005551_abnormal_eye_electrophysiolog	1.65608836
25	MP0002006_tumorigenesis	1.65603132
26	MP0002723_abnormal_immune_serum	1.63831427
27	MP0005377_hearing/vestibular/ear_phenot	1.60024852
28	MP0003878_abnormal_ear_physiology	1.60024852
29	MP0010386_abnormal_urinary_bladder	1.58923281
30	MP0002420_abnormal_adaptive_immunity	1.53539880
31	MP0001790_abnormal_immune_system	1.52315875
32	MP0005387_immune_system_phenotype	1.52315875
33	MP0002452_abnormal_antigen_presenting	1.52131464
34	MP0001819_abnormal_immune_cell	1.50614775
35	MP0000678_abnormal_parathyroid_gland	1.46999790
36	MP0005025_abnormal_response_to	1.40831845
37	MP0005075_abnormal_melanosome_morpholog	1.39284332
38	MP0002160_abnormal_reproductive_system	1.38996905
39	MP0000685_abnormal_immune_system	1.34280150
40	MP0003195_calcinosis	1.34106283
41	MP0002405_respiratory_system_inflammati	1.31161068
42	MP0004885_abnormal_endolymph	1.29486240
43	MP0002398_abnormal_bone_marrow	1.27882509
44	MP0005464_abnormal_platelet_physiology	1.26214194
45	MP0004145_abnormal_muscle_electrophysio	1.25028915
46	MP0006082_CNS_inflammation	1.24479188
47	MP0000716_abnormal_immune_system	1.23327865
48	MP0006276_abnormal_autonomic_nervous	1.19285076
49	MP0002234_abnormal_pharynx_morphology	1.15395671
50	MP0003866_abnormal_defecation	1.14183694
51	MP0002277_abnormal_respiratory_mucosa	1.14084036
52	MP0008995_early_reproductive_senescence	1.13684249
53	MP0010155_abnormal_intestine_physiology	1.11948813
54	MP0005389_reproductive_system_phenotype	1.11765914
55	MP0000689_abnormal_spleen_morphology	1.10452872
56	MP0003880_abnormal_central_pattern	1.10060279
57	MP0000681_abnormal_thyroid_gland	1.08303713
58	MP0005084_abnormal_gallbladder_morpholo	1.07351560
59	MP0003724_increased_susceptibility_to	1.06942329
60	MP0009697_abnormal_copulation	1.06699385
61	MP0000465_gastrointestinal_hemorrhage	1.05365808
62	MP0001485_abnormal_pinna_reflex	1.05045997
63	MP0000372_irregular_coat_pigmentation	1.04111100
64	MP0008875_abnormal_xenobiotic_pharmacok	1.01778468
65	MP0001905_abnormal_dopamine_level	1.01548756
66	MP0005253_abnormal_eye_physiology	1.01449378
67	MP0001968_abnormal_touch/_nociception	1.01155019
68	MP0001664_abnormal_digestion	1.00765927
69	MP0005360_urolithiasis	0.99678969
70	MP0004142_abnormal_muscle_tone	0.99550716
71	MP0002933_joint_inflammation	0.99185994
72	MP0008469_abnormal_protein_level	0.97176761
73	MP0002722_abnormal_immune_system	0.94144845
74	MP0001963_abnormal_hearing_physiology	0.92513340
75	MP0001501_abnormal_sleep_pattern	0.92420350
76	MP0001486_abnormal_startle_reflex	0.91941914
77	MP0002736_abnormal_nociception_after	0.89974621
78	MP0002009_preneoplasia	0.89321915
79	MP0008961_abnormal_basal_metabolism	0.88332004
80	MP0001986_abnormal_taste_sensitivity	0.88138495
81	MP0002429_abnormal_blood_cell	0.87092364
82	MP0000631_abnormal_neuroendocrine_gland	0.87067298
83	MP0001765_abnormal_ion_homeostasis	0.86499262
84	MP0002419_abnormal_innate_immunity	0.86395999
85	MP0004134_abnormal_chest_morphology	0.85806149
86	MP0005085_abnormal_gallbladder_physiolo	0.85595218
87	MP0003283_abnormal_digestive_organ	0.85159436
88	MP0001845_abnormal_inflammatory_respons	0.85100110
89	MP0008058_abnormal_DNA_repair	0.84976482
90	MP0002693_abnormal_pancreas_physiology	0.83546853
91	MP0005636_abnormal_mineral_homeostasis	0.83420264
92	MP0003252_abnormal_bile_duct	0.83292101
93	MP0000049_abnormal_middle_ear	0.80452237
94	MP0000703_abnormal_thymus_morphology	0.79935350
95	MP0008877_abnormal_DNA_methylation	0.76676509
96	MP0002272_abnormal_nervous_system	0.76374575
97	MP0002095_abnormal_skin_pigmentation	0.76285455
98	MP0005410_abnormal_fertilization	0.76168473
99	MP0004808_abnormal_hematopoietic_stem	0.75681878
100	MP0003786_premature_aging	0.75502607

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.89616559
2	Congenital stationary night blindness (HP:0007642)	4.82438792
3	Abnormality of B cell number (HP:0010975)	4.36605715
4	Hypoproteinemia (HP:0003075)	4.30879851
5	Severe combined immunodeficiency (HP:0004430)	4.21308538
6	B lymphocytopenia (HP:0010976)	3.96611149
7	Thyroiditis (HP:0100646)	3.93068622
8	Aplastic anemia (HP:0001915)	3.89506755
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.73602437
10	Attenuation of retinal blood vessels (HP:0007843)	3.46022838
11	Generalized aminoaciduria (HP:0002909)	3.36171673
12	Decreased central vision (HP:0007663)	3.36129722
13	Abolished electroretinogram (ERG) (HP:0000550)	3.32350829
14	Constricted visual fields (HP:0001133)	3.30535588
15	Elevated erythrocyte sedimentation rate (HP:0003565)	3.27169543
16	Combined immunodeficiency (HP:0005387)	3.22693285
17	Panhypogammaglobulinemia (HP:0003139)	3.11517021
18	T lymphocytopenia (HP:0005403)	3.08433192
19	Abnormality of T cell number (HP:0011839)	3.07599043
20	Pancreatic cysts (HP:0001737)	3.00044607
21	Methylmalonic acidemia (HP:0002912)	2.84143466
22	Mitochondrial inheritance (HP:0001427)	2.81996888
23	IgG deficiency (HP:0004315)	2.79606839
24	Autoimmune hemolytic anemia (HP:0001890)	2.72309584
25	Abnormality of the renal collecting system (HP:0004742)	2.68553340
26	Reduced antithrombin III activity (HP:0001976)	2.65068158
27	True hermaphroditism (HP:0010459)	2.60855084
28	3-Methylglutaconic aciduria (HP:0003535)	2.60646769
29	Acute necrotizing encephalopathy (HP:0006965)	2.59258844
30	Abnormality of the prostate (HP:0008775)	2.58589534
31	Hypoplasia of the thymus (HP:0000778)	2.57871212
32	Stenosis of the external auditory canal (HP:0000402)	2.56643501
33	Abnormality of DNA repair (HP:0003254)	2.52427403
34	Muscle hypertrophy of the lower extremities (HP:0008968)	2.48680410
35	Hepatic necrosis (HP:0002605)	2.48540659
36	Congenital, generalized hypertrichosis (HP:0004540)	2.46312178
37	Hepatocellular necrosis (HP:0001404)	2.44781308
38	Agammaglobulinemia (HP:0004432)	2.44566829
39	Renal cortical cysts (HP:0000803)	2.44537681
40	Molar tooth sign on MRI (HP:0002419)	2.44525571
41	Abnormality of midbrain morphology (HP:0002418)	2.44525571
42	Abnormality of urine glucose concentration (HP:0011016)	2.41144193
43	Glycosuria (HP:0003076)	2.41144193
44	Optic disc pallor (HP:0000543)	2.38458197
45	Pendular nystagmus (HP:0012043)	2.37273838
46	Abnormality of eosinophils (HP:0001879)	2.35266549
47	Increased intramyocellular lipid droplets (HP:0012240)	2.33641822
48	Severe visual impairment (HP:0001141)	2.32247442
49	Reticulocytopenia (HP:0001896)	2.31446354
50	Increased hepatocellular lipid droplets (HP:0006565)	2.31054836
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.29898771
52	Cerebral edema (HP:0002181)	2.27452251
53	Macrocytic anemia (HP:0001972)	2.27237086
54	Progressive macrocephaly (HP:0004481)	2.22508725
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20543489
56	Increased CSF lactate (HP:0002490)	2.19611906
57	Pancreatic fibrosis (HP:0100732)	2.19345148
58	Eosinophilia (HP:0001880)	2.17142093
59	Chronic sinusitis (HP:0011109)	2.13152082
60	Abnormality of cells of the erythroid lineage (HP:0012130)	2.11883212
61	Renal Fanconi syndrome (HP:0001994)	2.06604638
62	Type I transferrin isoform profile (HP:0003642)	2.05248851
63	Abnormal number of erythroid precursors (HP:0012131)	2.05123245
64	Abnormality of T cells (HP:0002843)	2.04230301
65	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.04049558
66	Abnormality of the renal cortex (HP:0011035)	2.02789326
67	Ketosis (HP:0001946)	2.01418214
68	Keratoconus (HP:0000563)	2.01137286
69	Increased corneal curvature (HP:0100692)	2.01137286
70	Abnormality of macular pigmentation (HP:0008002)	1.98585792
71	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.97415661
72	Acute encephalopathy (HP:0006846)	1.97337976
73	Abnormality of vitamin B metabolism (HP:0004340)	1.95582300
74	Lipid accumulation in hepatocytes (HP:0006561)	1.94791056
75	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.92536508
76	Exertional dyspnea (HP:0002875)	1.92154106
77	Methylmalonic aciduria (HP:0012120)	1.88668002
78	Leukocytosis (HP:0001974)	1.88232992
79	Myotonia (HP:0002486)	1.87461805
80	Encephalitis (HP:0002383)	1.85326660
81	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.85318170
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.84794824
83	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.82049338
84	Dyschromatopsia (HP:0007641)	1.82040730
85	Cystic liver disease (HP:0006706)	1.81054685
86	Amniotic constriction ring (HP:0009775)	1.80960963
87	Abnormality of placental membranes (HP:0011409)	1.80960963
88	Type 2 muscle fiber atrophy (HP:0003554)	1.79046573
89	Increased muscle lipid content (HP:0009058)	1.78962486
90	Lip pit (HP:0100267)	1.78321456
91	Absent/shortened dynein arms (HP:0200106)	1.77946942
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.77946942
93	Nephronophthisis (HP:0000090)	1.77620035
94	Mesangial abnormality (HP:0001966)	1.73011882
95	Hyperphosphaturia (HP:0003109)	1.72877881
96	Pallor (HP:0000980)	1.71148349
97	Stomatitis (HP:0010280)	1.71031357
98	Autoimmune thrombocytopenia (HP:0001973)	1.69083144
99	Meningitis (HP:0001287)	1.68763846
100	Neonatal respiratory distress (HP:0002643)	1.67969672

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.19464032
2	TXK	3.95407630
3	CDK19	3.89018162
4	KDR	3.13510663
5	GRK1	3.04222401
6	TAOK3	2.65869040
7	SCYL2	2.61804456
8	TESK2	2.39523680
9	ADRBK2	2.29335322
10	FRK	2.20582039
11	PASK	2.15029891
12	MAP4K1	2.05800122
13	SYK	1.92561870
14	TEC	1.89556722
15	ITK	1.79229639
16	ZAK	1.75881107
17	PINK1	1.74203936
18	MAP4K2	1.69056479
19	TRPM7	1.59937589
20	VRK2	1.59091855
21	EIF2AK3	1.59018987
22	KIT	1.56226212
23	TIE1	1.46738556
24	TNK2	1.43971701
25	GRK6	1.43354073
26	VRK1	1.42158609
27	MAP3K12	1.36830461
28	BTK	1.36093777
29	MUSK	1.32951737
30	FES	1.32267971
31	BMPR2	1.24925868
32	CSF1R	1.18950442
33	RPS6KA4	1.02152485
34	LCK	1.00709398
35	LYN	0.99446093
36	INSRR	0.97461174
37	TLK1	0.93668108
38	NUAK1	0.91565989
39	MAPKAPK5	0.89107065
40	MYLK	0.88724087
41	IKBKB	0.80518137
42	OXSR1	0.80140432
43	GRK7	0.79161118
44	FLT3	0.77771380
45	IKBKE	0.77032080
46	OBSCN	0.76978592
47	DAPK1	0.74735918
48	CAMKK2	0.72627750
49	ERBB3	0.72498869
50	PRKG2	0.71256525
51	RIPK4	0.70592861
52	MAP3K6	0.69717884
53	CAMKK1	0.69605752
54	WNK3	0.68535788
55	IGF1R	0.67716669
56	ADRBK1	0.67355809
57	DAPK2	0.65779836
58	CSK	0.64239356
59	ZAP70	0.63302512
60	PRKCQ	0.62921706
61	MAPK7	0.61253147
62	MAP2K6	0.59583230
63	PIK3CG	0.59136177
64	PRKCE	0.58944306
65	RPS6KA5	0.58787512
66	BMPR1B	0.58462966
67	MAPK13	0.57721872
68	PIM1	0.56985225
69	HCK	0.56393835
70	STK16	0.56094702
71	JAK3	0.55572995
72	EIF2AK2	0.54197033
73	TBK1	0.52828793
74	ABL1	0.52222885
75	ILK	0.51494533
76	CDK3	0.50724311
77	MATK	0.50385950
78	CSNK1G3	0.49049844
79	TRIM28	0.48961729
80	DAPK3	0.47049947
81	PRKCH	0.46731230
82	MKNK1	0.45271900
83	PRKACA	0.42918969
84	RPS6KB2	0.42852798
85	PRKCA	0.41291528
86	FYN	0.40572229
87	MAP3K5	0.36861264
88	INSR	0.34902774
89	CSNK1G1	0.33622565
90	MAP3K11	0.33280929
91	PRKCD	0.32822614
92	CAMK2A	0.32738506
93	TGFBR1	0.31999177
94	PRKD3	0.30845538
95	GRK5	0.30062652
96	PRKCB	0.30013078
97	CSNK2A2	0.29405986
98	CSNK2A1	0.29127805
99	CSNK1G2	0.29102004
100	LIMK1	0.28348300

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.68854090
2	Allograft rejection_Homo sapiens_hsa05330	3.50376542
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.26167377
4	Ribosome_Homo sapiens_hsa03010	3.22866238
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.22852713
6	Asthma_Homo sapiens_hsa05310	3.21840327
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.09724433
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.84574096
9	Phototransduction_Homo sapiens_hsa04744	2.45547166
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.38408312
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.30122992
12	Proteasome_Homo sapiens_hsa03050	2.16416029
13	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.79562340
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.71679391
15	Parkinsons disease_Homo sapiens_hsa05012	1.70981530
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51736902
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45942767
18	Viral myocarditis_Homo sapiens_hsa05416	1.43086729
19	Olfactory transduction_Homo sapiens_hsa04740	1.42342821
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42251457
21	Retinol metabolism_Homo sapiens_hsa00830	1.41724831
22	Propanoate metabolism_Homo sapiens_hsa00640	1.38173097
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36179939
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.35984529
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32577843
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28837741
27	RNA polymerase_Homo sapiens_hsa03020	1.24866736
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23207747
29	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.21665648
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21524876
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.20359890
32	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.18915677
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17605425
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15264533
35	Alzheimers disease_Homo sapiens_hsa05010	1.14846873
36	Protein export_Homo sapiens_hsa03060	1.14814316
37	Taste transduction_Homo sapiens_hsa04742	1.12992532
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.11729579
39	Caffeine metabolism_Homo sapiens_hsa00232	1.11648619
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10295943
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10122836
42	RNA degradation_Homo sapiens_hsa03018	1.08554885
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.06311674
44	African trypanosomiasis_Homo sapiens_hsa05143	0.97449609
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96550079
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95398163
47	Leishmaniasis_Homo sapiens_hsa05140	0.95004447
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.93440535
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.93386563
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91764144
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91630656
52	Huntingtons disease_Homo sapiens_hsa05016	0.90010427
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.89734087
54	Butanoate metabolism_Homo sapiens_hsa00650	0.83387261
55	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.82374893
56	Salivary secretion_Homo sapiens_hsa04970	0.80348344
57	Malaria_Homo sapiens_hsa05144	0.79127995
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.78548204
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77420149
60	Homologous recombination_Homo sapiens_hsa03440	0.77111174
61	Purine metabolism_Homo sapiens_hsa00230	0.76396292
62	Nicotine addiction_Homo sapiens_hsa05033	0.74589386
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.70520854
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70067193
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67229302
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.65718266
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64717661
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61381904
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.59763005
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57750340
71	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.53608018
72	Peroxisome_Homo sapiens_hsa04146	0.53564468
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52582548
74	Serotonergic synapse_Homo sapiens_hsa04726	0.52374978
75	One carbon pool by folate_Homo sapiens_hsa00670	0.50672873
76	Regulation of autophagy_Homo sapiens_hsa04140	0.48805712
77	Renin secretion_Homo sapiens_hsa04924	0.48771264
78	ABC transporters_Homo sapiens_hsa02010	0.47121505
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44218243
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42995568
81	Circadian entrainment_Homo sapiens_hsa04713	0.40760621
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39642634
83	Morphine addiction_Homo sapiens_hsa05032	0.38840859
84	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.38533798
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36825686
86	Herpes simplex infection_Homo sapiens_hsa05168	0.35037487
87	Legionellosis_Homo sapiens_hsa05134	0.31793180
88	Metabolic pathways_Homo sapiens_hsa01100	0.31093221
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.30810161
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.30556667
91	Base excision repair_Homo sapiens_hsa03410	0.29424943
92	Measles_Homo sapiens_hsa05162	0.29084385
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28291272
94	Spliceosome_Homo sapiens_hsa03040	0.26570064
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26348018
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25792880
97	GABAergic synapse_Homo sapiens_hsa04727	0.24207265
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.23910388
99	Pertussis_Homo sapiens_hsa05133	0.23787614
100	Platelet activation_Homo sapiens_hsa04611	0.23203565

RPS3AP41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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