ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.36273222
2	translational termination (GO:0006415)	8.01329023
3	ribosomal small subunit biogenesis (GO:0042274)	7.28867255
4	ribosomal small subunit assembly (GO:0000028)	6.86351051
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.40755010
6	translational elongation (GO:0006414)	6.39751001
7	cotranslational protein targeting to membrane (GO:0006613)	6.33748187
8	protein targeting to ER (GO:0045047)	6.29515372
9	substrate-independent telencephalic tangential migration (GO:0021826)	6.26789212
10	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	6.26789212
11	cellular protein complex disassembly (GO:0043624)	6.15665756
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.09043138
13	maturation of SSU-rRNA (GO:0030490)	6.08683183
14	viral life cycle (GO:0019058)	6.04128611
15	protein localization to endoplasmic reticulum (GO:0070972)	5.88123735
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.72368708
17	behavioral response to nicotine (GO:0035095)	5.53947504
18	protein complex disassembly (GO:0043241)	5.34648776
19	macromolecular complex disassembly (GO:0032984)	5.03022571
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.94046414
21	translational initiation (GO:0006413)	4.78878279
22	positive regulation of growth hormone secretion (GO:0060124)	4.58611758
23	cell proliferation in forebrain (GO:0021846)	4.41119865
24	protein targeting to membrane (GO:0006612)	4.35507381
25	protein neddylation (GO:0045116)	4.10358344
26	epithelial cilium movement (GO:0003351)	3.97167008
27	neuron fate determination (GO:0048664)	3.96345473
28	embryonic body morphogenesis (GO:0010172)	3.92462814
29	central nervous system myelination (GO:0022010)	3.88692579
30	axon ensheathment in central nervous system (GO:0032291)	3.88692579
31	body morphogenesis (GO:0010171)	3.85586596
32	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.82392476
33	axonal fasciculation (GO:0007413)	3.81065466
34	protein polyglutamylation (GO:0018095)	3.73721582
35	regulation of growth hormone secretion (GO:0060123)	3.72877898
36	auditory receptor cell differentiation (GO:0042491)	3.69818341
37	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.58975890
38	mRNA catabolic process (GO:0006402)	3.57886401
39	parturition (GO:0007567)	3.57694607
40	tongue development (GO:0043586)	3.57409608
41	nonmotile primary cilium assembly (GO:0035058)	3.46080491
42	ribosomal large subunit biogenesis (GO:0042273)	3.34075453
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.33081973
44	translation (GO:0006412)	3.31325614
45	pyrimidine nucleobase catabolic process (GO:0006208)	3.29826096
46	positive regulation of respiratory burst (GO:0060267)	3.27422018
47	somite development (GO:0061053)	3.19471634
48	chaperone-mediated protein transport (GO:0072321)	3.19245403
49	neuron recognition (GO:0008038)	3.18756190
50	GTP biosynthetic process (GO:0006183)	3.17759689
51	RNA catabolic process (GO:0006401)	3.17589479
52	pattern specification involved in kidney development (GO:0061004)	3.15664049
53	intraciliary transport (GO:0042073)	3.14548300
54	glycerophospholipid catabolic process (GO:0046475)	3.13431428
55	spinal cord association neuron differentiation (GO:0021527)	3.11996039
56	negative regulation of response to food (GO:0032096)	3.10298272
57	negative regulation of appetite (GO:0032099)	3.10298272
58	left/right pattern formation (GO:0060972)	3.08929625
59	establishment of protein localization to membrane (GO:0090150)	3.03249827
60	regulation of cilium movement (GO:0003352)	3.02028846
61	ubiquinone biosynthetic process (GO:0006744)	3.01911901
62	ribonucleoprotein complex biogenesis (GO:0022613)	3.01328317
63	motile cilium assembly (GO:0044458)	2.98602500
64	thalamus development (GO:0021794)	2.98485968
65	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.96911452
66	growth hormone secretion (GO:0030252)	2.96652860
67	cilium movement (GO:0003341)	2.95345448
68	cardiovascular system development (GO:0072358)	2.91999873
69	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.90390473
70	ATP synthesis coupled proton transport (GO:0015986)	2.90390473
71	regulation of microtubule-based movement (GO:0060632)	2.88457175
72	ubiquinone metabolic process (GO:0006743)	2.84637147
73	telencephalon development (GO:0021537)	2.83485043
74	forebrain neuron differentiation (GO:0021879)	2.83463672
75	microtubule severing (GO:0051013)	2.82886951
76	myoblast migration (GO:0051451)	2.81596773
77	spinal cord development (GO:0021510)	2.79173743
78	axoneme assembly (GO:0035082)	2.78270240
79	cellular component biogenesis (GO:0044085)	2.77424485
80	UTP biosynthetic process (GO:0006228)	2.77393427
81	synaptic transmission, cholinergic (GO:0007271)	2.77073208
82	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.76683658
83	genetic imprinting (GO:0071514)	2.76055302
84	neuronal stem cell maintenance (GO:0097150)	2.74336326
85	dentate gyrus development (GO:0021542)	2.73692595
86	appendage development (GO:0048736)	2.72115332
87	limb development (GO:0060173)	2.72115332
88	forebrain morphogenesis (GO:0048853)	2.67793263
89	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.67735505
90	protein targeting (GO:0006605)	2.67689729
91	UTP metabolic process (GO:0046051)	2.65927355
92	regulation of telomerase activity (GO:0051972)	2.62004819
93	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.61735426
94	nucleobase catabolic process (GO:0046113)	2.59761869
95	neurofilament cytoskeleton organization (GO:0060052)	2.56285233
96	dendritic spine morphogenesis (GO:0060997)	2.53831914
97	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.53619871
98	segment specification (GO:0007379)	2.53032383
99	camera-type eye morphogenesis (GO:0048593)	2.52419552
100	radial glial cell differentiation (GO:0060019)	2.50906365

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.88187293
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.64091434
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.03714450
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.98532405
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.89697235
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.75205737
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.53147036
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.45125699
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.39680671
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.36294992
11	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.34933367
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.20673341
13	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.19069001
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.19069001
15	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.16409802
16	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.16161301
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.16160599
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.96188510
19	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.89344955
20	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.82278956
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.80147347
22	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.78262015
23	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.76210365
24	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.75153268
25	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.74628887
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71063096
27	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.67064211
28	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.58421467
29	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.57633068
30	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.55835867
31	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.55767213
32	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.54474655
33	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.52941394
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49943936
35	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.48929557
36	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.46956334
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46129584
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45272051
39	CTCF_27219007_Chip-Seq_Bcells_Human	1.40506872
40	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.38926001
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.36372570
42	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.36300103
43	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.33295665
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.33271938
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.32973825
46	ZNF274_21170338_ChIP-Seq_K562_Hela	1.28246553
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23883558
48	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.15767370
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15557957
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.13746815
51	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.13581154
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12374508
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10476305
54	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09428192
55	VDR_22108803_ChIP-Seq_LS180_Human	1.09391382
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.08994774
57	DROSHA_22980978_ChIP-Seq_HELA_Human	1.06144174
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04961883
59	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.04417215
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03663101
61	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.03480555
62	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02169817
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01285630
64	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.00741181
65	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99573686
66	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99481953
67	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98771506
68	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.98065969
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97611025
70	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.97076726
71	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96898707
72	TTF2_22483619_ChIP-Seq_HELA_Human	0.96889802
73	ERA_21632823_ChIP-Seq_H3396_Human	0.96543732
74	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.96386260
75	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.96076567
76	TP53_22573176_ChIP-Seq_HFKS_Human	0.94713123
77	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94199758
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92897721
79	MYC_18940864_ChIP-ChIP_HL60_Human	0.90807182
80	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.90492940
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89953219
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89488199
83	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.88528162
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87604571
85	FUS_26573619_Chip-Seq_HEK293_Human	0.86512882
86	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.86150021
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86105723
88	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.85263145
89	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.85012828
90	NCOR_22424771_ChIP-Seq_293T_Human	0.84723983
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.84198075
92	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.82647826
93	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.81750054
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80211847
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79728970
96	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.79728970
97	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.77772931
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.77573979
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.75730116
100	SA1_27219007_Chip-Seq_Bcells_Human	0.75635048

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.09065329
2	MP0006292_abnormal_olfactory_placode	4.82244934
3	MP0003787_abnormal_imprinting	3.81443197
4	MP0003123_paternal_imprinting	3.17696428
5	MP0003122_maternal_imprinting	3.00911498
6	MP0008789_abnormal_olfactory_epithelium	3.00606319
7	MP0002653_abnormal_ependyma_morphology	2.94901588
8	MP0005394_taste/olfaction_phenotype	2.71380486
9	MP0005499_abnormal_olfactory_system	2.71380486
10	MP0000778_abnormal_nervous_system	2.55417714
11	MP0004142_abnormal_muscle_tone	2.41451810
12	MP0002163_abnormal_gland_morphology	2.29200983
13	MP0003880_abnormal_central_pattern	2.25839263
14	MP0003121_genomic_imprinting	2.11419370
15	MP0003878_abnormal_ear_physiology	2.08413419
16	MP0005377_hearing/vestibular/ear_phenot	2.08413419
17	MP0005423_abnormal_somatic_nervous	2.02640507
18	MP0001293_anophthalmia	1.96173232
19	MP0006276_abnormal_autonomic_nervous	1.90672029
20	MP0004885_abnormal_endolymph	1.89469289
21	MP0000049_abnormal_middle_ear	1.87960268
22	MP0002102_abnormal_ear_morphology	1.80126442
23	MP0004145_abnormal_muscle_electrophysio	1.78548449
24	MP0001485_abnormal_pinna_reflex	1.76049145
25	MP0008877_abnormal_DNA_methylation	1.76020055
26	MP0010030_abnormal_orbit_morphology	1.69457164
27	MP0003646_muscle_fatigue	1.60016059
28	MP0002557_abnormal_social/conspecific_i	1.59231477
29	MP0001440_abnormal_grooming_behavior	1.58303060
30	MP0002272_abnormal_nervous_system	1.50304835
31	MP0002160_abnormal_reproductive_system	1.46302180
32	MP0004742_abnormal_vestibular_system	1.43813550
33	MP0000631_abnormal_neuroendocrine_gland	1.43705770
34	MP0001529_abnormal_vocalization	1.38371550
35	MP0002233_abnormal_nose_morphology	1.37518296
36	MP0000955_abnormal_spinal_cord	1.37249457
37	MP0003938_abnormal_ear_development	1.36124241
38	MP0002733_abnormal_thermal_nociception	1.34309298
39	MP0003136_yellow_coat_color	1.30697943
40	MP0002638_abnormal_pupillary_reflex	1.30011052
41	MP0001970_abnormal_pain_threshold	1.27633435
42	MP0005551_abnormal_eye_electrophysiolog	1.27452997
43	MP0002184_abnormal_innervation	1.26529512
44	MP0002938_white_spotting	1.26507933
45	MP0002063_abnormal_learning/memory/cond	1.24977992
46	MP0000026_abnormal_inner_ear	1.23134505
47	MP0001968_abnormal_touch/_nociception	1.22061436
48	MP0003879_abnormal_hair_cell	1.21370133
49	MP0002752_abnormal_somatic_nervous	1.21336002
50	MP0005195_abnormal_posterior_eye	1.18512062
51	MP0003942_abnormal_urinary_system	1.18434380
52	MP0003635_abnormal_synaptic_transmissio	1.18185857
53	MP0001502_abnormal_circadian_rhythm	1.17447122
54	MP0001286_abnormal_eye_development	1.17176994
55	MP0009745_abnormal_behavioral_response	1.16541662
56	MP0005379_endocrine/exocrine_gland_phen	1.15394340
57	MP0001188_hyperpigmentation	1.13319950
58	MP0002572_abnormal_emotion/affect_behav	1.10699524
59	MP0002736_abnormal_nociception_after	1.09627728
60	MP0004859_abnormal_synaptic_plasticity	1.07365625
61	MP0002734_abnormal_mechanical_nocicepti	1.07060425
62	MP0001905_abnormal_dopamine_level	1.06820928
63	MP0004133_heterotaxia	1.05935618
64	MP0002822_catalepsy	1.05284476
65	MP0001486_abnormal_startle_reflex	1.04727664
66	MP0003937_abnormal_limbs/digits/tail_de	1.03608447
67	MP0002152_abnormal_brain_morphology	1.03331468
68	MP0001963_abnormal_hearing_physiology	1.02860940
69	MP0009053_abnormal_anal_canal	1.02763920
70	MP0001984_abnormal_olfaction	1.02684646
71	MP0002067_abnormal_sensory_capabilities	1.02452166
72	MP0002882_abnormal_neuron_morphology	1.01454677
73	MP0003861_abnormal_nervous_system	1.01446838
74	MP0005389_reproductive_system_phenotype	0.99377881
75	MP0003755_abnormal_palate_morphology	0.99275426
76	MP0002095_abnormal_skin_pigmentation	0.93428365
77	MP0005645_abnormal_hypothalamus_physiol	0.90685245
78	MP0009250_abnormal_appendicular_skeleto	0.89756662
79	MP0002210_abnormal_sex_determination	0.88723504
80	MP0003119_abnormal_digestive_system	0.88006934
81	MP0002249_abnormal_larynx_morphology	0.86126184
82	MP0009046_muscle_twitch	0.84158147
83	MP0002116_abnormal_craniofacial_bone	0.82183646
84	MP0003567_abnormal_fetal_cardiomyocyte	0.81934604
85	MP0002837_dystrophic_cardiac_calcinosis	0.81432535
86	MP0000678_abnormal_parathyroid_gland	0.80605806
87	MP0002234_abnormal_pharynx_morphology	0.76866695
88	MP0000566_synostosis	0.75468119
89	MP0004811_abnormal_neuron_physiology	0.73114201
90	MP0005084_abnormal_gallbladder_morpholo	0.72911174
91	MP0002064_seizures	0.71062778
92	MP0003890_abnormal_embryonic-extraembry	0.70217173
93	MP0002697_abnormal_eye_size	0.69767056
94	MP0004147_increased_porphyrin_level	0.67884182
95	MP0005257_abnormal_intraocular_pressure	0.67352751
96	MP0000230_abnormal_systemic_arterial	0.67273987
97	MP0002092_abnormal_eye_morphology	0.67194261
98	MP0005386_behavior/neurological_phenoty	0.66165142
99	MP0004924_abnormal_behavior	0.66165142
100	MP0000428_abnormal_craniofacial_morphol	0.65813249

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.01388136
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.64539084
3	Macrocytic anemia (HP:0001972)	4.15139809
4	Hepatoblastoma (HP:0002884)	3.82408701
5	Pancreatic fibrosis (HP:0100732)	3.69092954
6	Septo-optic dysplasia (HP:0100842)	3.47676346
7	Myokymia (HP:0002411)	3.35082672
8	Abnormal number of erythroid precursors (HP:0012131)	3.31855758
9	Molar tooth sign on MRI (HP:0002419)	3.20866471
10	Abnormality of midbrain morphology (HP:0002418)	3.20866471
11	Pallor (HP:0000980)	3.15334647
12	Diastasis recti (HP:0001540)	3.10625377
13	Stenosis of the external auditory canal (HP:0000402)	3.04128385
14	Type II lissencephaly (HP:0007260)	3.03755330
15	Oligodactyly (hands) (HP:0001180)	2.96790523
16	Neoplasm of the adrenal cortex (HP:0100641)	2.88527409
17	Absent/shortened dynein arms (HP:0200106)	2.87116403
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.87116403
19	Medial flaring of the eyebrow (HP:0010747)	2.86231527
20	Colon cancer (HP:0003003)	2.69405357
21	Pancreatic cysts (HP:0001737)	2.68141592
22	Abnormality of the labia minora (HP:0012880)	2.64005259
23	Acute necrotizing encephalopathy (HP:0006965)	2.61703908
24	Rib fusion (HP:0000902)	2.58746260
25	Abnormality of DNA repair (HP:0003254)	2.58537308
26	Pendular nystagmus (HP:0012043)	2.56885473
27	Gait imbalance (HP:0002141)	2.56841054
28	Nephronophthisis (HP:0000090)	2.56244269
29	Absent thumb (HP:0009777)	2.53922649
30	True hermaphroditism (HP:0010459)	2.53720742
31	Oligodactyly (HP:0012165)	2.52745971
32	Asplenia (HP:0001746)	2.52300322
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.51856255
34	Growth hormone deficiency (HP:0000824)	2.46486661
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.46389089
36	Congenital primary aphakia (HP:0007707)	2.43773194
37	Abnormal pancreas size (HP:0012094)	2.41638138
38	Maternal diabetes (HP:0009800)	2.40324393
39	Adrenal hypoplasia (HP:0000835)	2.39605743
40	Anophthalmia (HP:0000528)	2.39256854
41	Depressed nasal ridge (HP:0000457)	2.32952523
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.32412752
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.32110236
44	Hyperthyroidism (HP:0000836)	2.32051285
45	Nephrogenic diabetes insipidus (HP:0009806)	2.30840068
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.30009695
47	Acute encephalopathy (HP:0006846)	2.28349728
48	Anomalous pulmonary venous return (HP:0010772)	2.28002657
49	Optic nerve hypoplasia (HP:0000609)	2.27170346
50	Abnormal respiratory epithelium morphology (HP:0012253)	2.25327455
51	Abnormal respiratory motile cilium morphology (HP:0005938)	2.25327455
52	Congenital malformation of the right heart (HP:0011723)	2.23342760
53	Double outlet right ventricle (HP:0001719)	2.23342760
54	Anencephaly (HP:0002323)	2.18580853
55	Cystic liver disease (HP:0006706)	2.18496299
56	Cerebellar dysplasia (HP:0007033)	2.16285469
57	Polyphagia (HP:0002591)	2.16213151
58	Lissencephaly (HP:0001339)	2.14422068
59	Poor coordination (HP:0002370)	2.13655398
60	Abnormality of the renal medulla (HP:0100957)	2.11705103
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.10815481
62	Hypoplasia of the radius (HP:0002984)	2.09753985
63	Ectopic kidney (HP:0000086)	2.08330745
64	Deep palmar crease (HP:0006191)	2.08259082
65	Horseshoe kidney (HP:0000085)	2.06751508
66	Progressive cerebellar ataxia (HP:0002073)	2.01878556
67	Abnormality of the aortic arch (HP:0012303)	2.00161284
68	Poor suck (HP:0002033)	1.98354443
69	Abnormality of the pulmonary veins (HP:0011718)	1.96787721
70	Hypoplasia of the ulna (HP:0003022)	1.96178785
71	Mitochondrial inheritance (HP:0001427)	1.95808976
72	Supernumerary spleens (HP:0009799)	1.95749536
73	Abnormal ciliary motility (HP:0012262)	1.94669236
74	Abnormality of the 4th metacarpal (HP:0010012)	1.94366156
75	Sclerocornea (HP:0000647)	1.94264042
76	Progressive macrocephaly (HP:0004481)	1.90826831
77	Congenital stationary night blindness (HP:0007642)	1.90519152
78	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.90239674
79	Pachygyria (HP:0001302)	1.88940041
80	Agitation (HP:0000713)	1.88257172
81	Anterior segment dysgenesis (HP:0007700)	1.88040272
82	Congenital hepatic fibrosis (HP:0002612)	1.87476211
83	Vaginal atresia (HP:0000148)	1.86345118
84	Neonatal hypoglycemia (HP:0001998)	1.84999483
85	Facial hemangioma (HP:0000329)	1.83587956
86	Metaphyseal dysplasia (HP:0100255)	1.81639080
87	Forearm undergrowth (HP:0009821)	1.81478356
88	Absent septum pellucidum (HP:0001331)	1.81254587
89	Porencephaly (HP:0002132)	1.81176255
90	Genital tract atresia (HP:0001827)	1.80502130
91	Abnormal hair whorl (HP:0010721)	1.80407304
92	Holoprosencephaly (HP:0001360)	1.79358651
93	Retinal dysplasia (HP:0007973)	1.78518255
94	Optic nerve coloboma (HP:0000588)	1.76164583
95	Increased CSF lactate (HP:0002490)	1.75792722
96	Dandy-Walker malformation (HP:0001305)	1.74986932
97	Chronic hepatic failure (HP:0100626)	1.74466015
98	Abnormal hemoglobin (HP:0011902)	1.74455585
99	Postaxial foot polydactyly (HP:0001830)	1.74150462
100	Meningocele (HP:0002435)	1.73707575

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.86462634
2	STK16	3.58095415
3	CDK19	3.12826700
4	DYRK2	2.63594286
5	EPHA4	2.59188197
6	PIK3CA	2.45533573
7	EPHB2	2.39740452
8	PRKD3	2.20099300
9	MAP3K11	2.07167111
10	CAMK1D	1.99759856
11	TNIK	1.92332776
12	CAMKK2	1.91521424
13	BCKDK	1.87304721
14	ARAF	1.85537325
15	MAP3K9	1.81686809
16	STK39	1.80657520
17	MAP2K7	1.68340249
18	LRRK2	1.66296662
19	ADRBK2	1.62657614
20	PINK1	1.59932760
21	BRAF	1.58961760
22	NTRK2	1.55654334
23	TYRO3	1.55524356
24	GRK1	1.53902136
25	CAMK1G	1.51336021
26	CAMKK1	1.48832971
27	CASK	1.46310465
28	DYRK1B	1.42827571
29	CDC7	1.42655319
30	MARK1	1.40025755
31	PRKCG	1.38585942
32	TLK1	1.36457255
33	CAMK1	1.34797582
34	NTRK3	1.20536549
35	PDK2	1.20026920
36	RPS6KA6	1.15010789
37	TIE1	1.12721456
38	STK11	1.11061204
39	MAPK15	1.06210226
40	MARK2	1.05852592
41	SGK223	1.04315973
42	SGK494	1.04315973
43	RPS6KC1	1.02220542
44	RPS6KL1	1.02220542
45	MAPK13	1.01028639
46	ZAK	0.97015032
47	CAMK4	0.96783520
48	WNK1	0.93588059
49	NEK2	0.93386853
50	BMPR1B	0.90436061
51	NEK1	0.90069503
52	NME1	0.88870081
53	ADRBK1	0.88631739
54	OXSR1	0.88003985
55	DAPK3	0.86520049
56	BRSK1	0.86257893
57	RPS6KA2	0.83153160
58	PRKCQ	0.82391830
59	AURKA	0.82365343
60	DYRK3	0.81858309
61	DMPK	0.80176942
62	MINK1	0.77807274
63	NUAK1	0.76757044
64	MAP2K4	0.75939989
65	ICK	0.73723991
66	MOS	0.73501613
67	NTRK1	0.71000071
68	SGK2	0.70070373
69	MAP3K4	0.69968965
70	PRKACA	0.65664923
71	SGK1	0.65011224
72	PAK3	0.62613992
73	PLK1	0.61859824
74	PRKCH	0.61465196
75	PLK2	0.56071670
76	CSNK1E	0.54828557
77	FRK	0.54292892
78	ERBB2	0.54125792
79	PRKCZ	0.53606566
80	OBSCN	0.51007599
81	AURKB	0.50854674
82	AKT1	0.49917955
83	CDK5	0.49444532
84	PIM2	0.49437487
85	CSNK2A2	0.47652286
86	INSRR	0.47042088
87	UHMK1	0.46953850
88	NME2	0.45590097
89	SIK2	0.44847332
90	PRKCD	0.44507377
91	TAF1	0.43974852
92	BTK	0.41547796
93	DYRK1A	0.40369141
94	WNK3	0.40094086
95	CDK11A	0.37597290
96	CAMK2A	0.36979776
97	CDK14	0.35983505
98	PRKACG	0.35266638
99	PRKCA	0.34517574
100	RPS6KA3	0.33804614

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.63406082
2	Sulfur relay system_Homo sapiens_hsa04122	3.57443838
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.18914614
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.80603568
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.78025707
6	Parkinsons disease_Homo sapiens_hsa05012	2.70377000
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.64463516
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.45450348
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44120765
10	Huntingtons disease_Homo sapiens_hsa05016	2.01917076
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00503308
12	Nicotine addiction_Homo sapiens_hsa05033	1.94326832
13	Alzheimers disease_Homo sapiens_hsa05010	1.80589274
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67305733
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.66129291
16	Notch signaling pathway_Homo sapiens_hsa04330	1.65480379
17	Fat digestion and absorption_Homo sapiens_hsa04975	1.61966909
18	Basal cell carcinoma_Homo sapiens_hsa05217	1.61474958
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.50095741
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.29771121
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29576306
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28048529
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20821875
24	Basal transcription factors_Homo sapiens_hsa03022	1.14853772
25	Axon guidance_Homo sapiens_hsa04360	1.14277190
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.13652433
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.12503948
28	Phototransduction_Homo sapiens_hsa04744	1.09581826
29	Peroxisome_Homo sapiens_hsa04146	1.08470352
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07429078
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02436772
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01984352
33	Protein export_Homo sapiens_hsa03060	0.96484972
34	Nitrogen metabolism_Homo sapiens_hsa00910	0.92052533
35	Folate biosynthesis_Homo sapiens_hsa00790	0.90425541
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89429312
37	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.88448894
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86329497
39	Morphine addiction_Homo sapiens_hsa05032	0.85431524
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85305297
41	Homologous recombination_Homo sapiens_hsa03440	0.84249605
42	Insulin secretion_Homo sapiens_hsa04911	0.83767798
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83055397
44	RNA degradation_Homo sapiens_hsa03018	0.82835245
45	RNA polymerase_Homo sapiens_hsa03020	0.79119225
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.78458376
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.73088071
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72176560
49	Olfactory transduction_Homo sapiens_hsa04740	0.71092466
50	Retinol metabolism_Homo sapiens_hsa00830	0.68904582
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68546827
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64901335
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64045533
54	Cocaine addiction_Homo sapiens_hsa05030	0.63137505
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.61351413
56	Metabolic pathways_Homo sapiens_hsa01100	0.61284887
57	Butanoate metabolism_Homo sapiens_hsa00650	0.59575019
58	Regulation of autophagy_Homo sapiens_hsa04140	0.59105639
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58573090
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58290886
61	Caffeine metabolism_Homo sapiens_hsa00232	0.57108051
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56703448
63	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55772678
64	GABAergic synapse_Homo sapiens_hsa04727	0.55612853
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54054881
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.53310859
67	Propanoate metabolism_Homo sapiens_hsa00640	0.52389985
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51246650
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51209935
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49890398
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.49498611
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.49404219
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47910778
74	Arginine biosynthesis_Homo sapiens_hsa00220	0.47555020
75	Cholinergic synapse_Homo sapiens_hsa04725	0.47261679
76	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45300609
77	Fatty acid degradation_Homo sapiens_hsa00071	0.45201996
78	One carbon pool by folate_Homo sapiens_hsa00670	0.42966233
79	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.41907281
80	Serotonergic synapse_Homo sapiens_hsa04726	0.41188547
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41011527
82	Melanogenesis_Homo sapiens_hsa04916	0.40642468
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.40066480
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.40029027
85	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.37235857
86	Circadian entrainment_Homo sapiens_hsa04713	0.36933712
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35243826
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34406661
89	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.33952126
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33346700
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32961031
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.31779165
93	Long-term depression_Homo sapiens_hsa04730	0.31428079
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.30673356
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30221237
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29447697
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29359532
98	Taste transduction_Homo sapiens_hsa04742	0.29121624
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.25561935
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.25271555

RPS3AP42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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