ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.84002622
2	maturation of SSU-rRNA (GO:0030490)	5.77045873
3	DNA deamination (GO:0045006)	5.26845166
4	viral transcription (GO:0019083)	5.03537864
5	translational termination (GO:0006415)	4.92107005
6	proteasome assembly (GO:0043248)	4.89307720
7	ATP synthesis coupled proton transport (GO:0015986)	4.68003723
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.68003723
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.64676280
10	ribosomal large subunit biogenesis (GO:0042273)	4.60986247
11	cotranslational protein targeting to membrane (GO:0006613)	4.59334744
12	ribosomal small subunit biogenesis (GO:0042274)	4.55661841
13	protein targeting to ER (GO:0045047)	4.52075112
14	chaperone-mediated protein transport (GO:0072321)	4.45136789
15	translational elongation (GO:0006414)	4.38969492
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.32230325
17	protein localization to endoplasmic reticulum (GO:0070972)	4.32077476
18	protein neddylation (GO:0045116)	4.26354168
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.25486532
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.17721575
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.13937853
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.10736635
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.10736635
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.05212407
25	GTP biosynthetic process (GO:0006183)	3.95523767
26	regulation of immunoglobulin secretion (GO:0051023)	3.93105409
27	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.87449703
28	translation (GO:0006412)	3.85079177
29	translational initiation (GO:0006413)	3.75445857
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.69956323
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.69173976
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.69173976
33	NADH dehydrogenase complex assembly (GO:0010257)	3.69173976
34	regulation of isotype switching to IgG isotypes (GO:0048302)	3.66560060
35	viral life cycle (GO:0019058)	3.59205215
36	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.55616579
37	cellular protein complex disassembly (GO:0043624)	3.55197345
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52260337
39	maturation of 5.8S rRNA (GO:0000460)	3.48714633
40	rRNA catabolic process (GO:0016075)	3.48506366
41	rRNA metabolic process (GO:0016072)	3.41475424
42	protein complex biogenesis (GO:0070271)	3.39966919
43	UTP biosynthetic process (GO:0006228)	3.39464040
44	rRNA processing (GO:0006364)	3.38679512
45	ribonucleoprotein complex biogenesis (GO:0022613)	3.22265281
46	UTP metabolic process (GO:0046051)	3.22249675
47	electron transport chain (GO:0022900)	3.21049609
48	respiratory electron transport chain (GO:0022904)	3.20098270
49	pseudouridine synthesis (GO:0001522)	3.19427257
50	water-soluble vitamin biosynthetic process (GO:0042364)	3.17665204
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.14720869
52	termination of RNA polymerase III transcription (GO:0006386)	3.14720869
53	cellular component biogenesis (GO:0044085)	3.14669622
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12280240
55	positive regulation of immune response to tumor cell (GO:0002839)	3.07601464
56	regulation of immune response to tumor cell (GO:0002837)	3.07601464
57	regulation of response to tumor cell (GO:0002834)	3.07601464
58	positive regulation of response to tumor cell (GO:0002836)	3.07601464
59	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.06180467
60	cullin deneddylation (GO:0010388)	3.01593570
61	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.01196562
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.00872334
63	histone mRNA metabolic process (GO:0008334)	3.00603999
64	rRNA modification (GO:0000154)	2.98245825
65	mRNA catabolic process (GO:0006402)	2.90727969
66	regulation of chronic inflammatory response (GO:0002676)	2.89067559
67	CTP biosynthetic process (GO:0006241)	2.88811370
68	CTP metabolic process (GO:0046036)	2.88811370
69	tRNA processing (GO:0008033)	2.87400272
70	protein complex disassembly (GO:0043241)	2.87109136
71	protein targeting to membrane (GO:0006612)	2.86984074
72	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.83152189
73	cellular ketone body metabolic process (GO:0046950)	2.82100410
74	regulation of regulatory T cell differentiation (GO:0045589)	2.81706264
75	protein deneddylation (GO:0000338)	2.80005368
76	macromolecular complex disassembly (GO:0032984)	2.79928349
77	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.71597376
78	ATP biosynthetic process (GO:0006754)	2.70982408
79	RNA catabolic process (GO:0006401)	2.69412684
80	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.68940265
81	platelet dense granule organization (GO:0060155)	2.68339761
82	tRNA metabolic process (GO:0006399)	2.68228566
83	positive regulation of muscle cell apoptotic process (GO:0010661)	2.67669185
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67597888
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.67535334
86	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.67535334
87	isotype switching (GO:0045190)	2.67535334
88	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.65604859
89	ncRNA metabolic process (GO:0034660)	2.64830136
90	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.64818985
91	ncRNA processing (GO:0034470)	2.63459808
92	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.62783174
93	regulation of mitotic spindle checkpoint (GO:1903504)	2.62783174
94	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.62518086
95	guanosine-containing compound biosynthetic process (GO:1901070)	2.60980363
96	peptidyl-histidine modification (GO:0018202)	2.58465575
97	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.57239115
98	axoneme assembly (GO:0035082)	2.55392167
99	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.54252256
100	rRNA methylation (GO:0031167)	2.53951880

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.61618688
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.39302429
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.77973014
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.76935647
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.75074674
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.09284797
7	VDR_22108803_ChIP-Seq_LS180_Human	2.94038718
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89448399
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.75474701
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.67983826
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65098869
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.35628301
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34553444
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29050163
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.26189793
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21135569
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.17883990
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05325386
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03519373
20	MYC_18940864_ChIP-ChIP_HL60_Human	2.01215116
21	EWS_26573619_Chip-Seq_HEK293_Human	1.90590949
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82402554
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80640427
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78459230
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.74515002
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.72400004
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72193493
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68827172
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68177718
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65124161
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.59012082
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50397657
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46460466
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.43807891
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40740547
36	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.40047357
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38990413
38	P300_19829295_ChIP-Seq_ESCs_Human	1.31203168
39	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.30219645
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28496122
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27523286
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27373369
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27212111
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27212111
45	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.26602041
46	FUS_26573619_Chip-Seq_HEK293_Human	1.23178559
47	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.18965686
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.18131752
49	AR_20517297_ChIP-Seq_VCAP_Human	1.18092609
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17449339
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16622006
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14933425
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14916106
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12348607
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12245500
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.11827575
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11633625
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10491093
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10491093
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09499460
61	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.07802767
62	DCP1A_22483619_ChIP-Seq_HELA_Human	1.06904734
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06641671
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.05805231
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.05690198
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05470472
67	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04918466
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04844026
69	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04572954
70	NCOR_22424771_ChIP-Seq_293T_Human	1.03846147
71	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03688622
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03510268
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02578825
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00322609
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99829758
76	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.99683529
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99582495
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98204706
79	GATA3_26560356_Chip-Seq_TH2_Human	0.97962648
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97401173
81	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.96643157
82	IGF1R_20145208_ChIP-Seq_DFB_Human	0.95931784
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95647640
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95459611
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95422561
86	CBP_20019798_ChIP-Seq_JUKART_Human	0.95422561
87	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95242560
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94530140
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93119779
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.93030501
91	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.92180667
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91536665
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.90114900
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.90089697
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89960432
96	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.89065242
97	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88824773
98	ERA_21632823_ChIP-Seq_H3396_Human	0.88704096
99	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87800459
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.87333055

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.37872064
2	MP0006292_abnormal_olfactory_placode	3.42746050
3	MP0004145_abnormal_muscle_electrophysio	3.10018175
4	MP0001835_abnormal_antigen_presentation	2.89187819
5	MP0003806_abnormal_nucleotide_metabolis	2.70409581
6	MP0008877_abnormal_DNA_methylation	2.50933710
7	MP0003787_abnormal_imprinting	2.46647605
8	MP0005360_urolithiasis	2.38290309
9	MP0005671_abnormal_response_to	2.37561782
10	MP0004885_abnormal_endolymph	2.33735906
11	MP0006072_abnormal_retinal_apoptosis	2.31191434
12	MP0004147_increased_porphyrin_level	2.29657192
13	MP0002102_abnormal_ear_morphology	2.22876818
14	MP0008872_abnormal_physiological_respon	2.13354428
15	MP0008875_abnormal_xenobiotic_pharmacok	2.10927010
16	MP0004142_abnormal_muscle_tone	1.77982066
17	MP0003195_calcinosis	1.73367660
18	MP0005646_abnormal_pituitary_gland	1.71676965
19	MP0002138_abnormal_hepatobiliary_system	1.67095448
20	MP0005645_abnormal_hypothalamus_physiol	1.67027272
21	MP0002837_dystrophic_cardiac_calcinosis	1.65538034
22	MP0001873_stomach_inflammation	1.63350552
23	MP0002736_abnormal_nociception_after	1.61966764
24	MP0000685_abnormal_immune_system	1.60379960
25	MP0005075_abnormal_melanosome_morpholog	1.58702888
26	MP0003646_muscle_fatigue	1.58487025
27	MP0008058_abnormal_DNA_repair	1.54539238
28	MP0002148_abnormal_hypersensitivity_rea	1.53930569
29	MP0002160_abnormal_reproductive_system	1.52643235
30	MP0001188_hyperpigmentation	1.49751141
31	MP0001529_abnormal_vocalization	1.42565760
32	MP0005389_reproductive_system_phenotype	1.41282870
33	MP0001968_abnormal_touch/_nociception	1.40851935
34	MP0005551_abnormal_eye_electrophysiolog	1.40005050
35	MP0001790_abnormal_immune_system	1.36543224
36	MP0005387_immune_system_phenotype	1.36543224
37	MP0003693_abnormal_embryo_hatching	1.34481759
38	MP0001800_abnormal_humoral_immune	1.30244639
39	MP0008789_abnormal_olfactory_epithelium	1.30104553
40	MP0005377_hearing/vestibular/ear_phenot	1.28441074
41	MP0003878_abnormal_ear_physiology	1.28441074
42	MP0009785_altered_susceptibility_to	1.26232700
43	MP0000372_irregular_coat_pigmentation	1.21920038
44	MP0002163_abnormal_gland_morphology	1.21766443
45	MP0009764_decreased_sensitivity_to	1.20164778
46	MP0003567_abnormal_fetal_cardiomyocyte	1.19423319
47	MP0002277_abnormal_respiratory_mucosa	1.15480022
48	MP0000631_abnormal_neuroendocrine_gland	1.13390223
49	MP0003786_premature_aging	1.13312850
50	MP0002234_abnormal_pharynx_morphology	1.11369052
51	MP0001984_abnormal_olfaction	1.11284734
52	MP0008995_early_reproductive_senescence	1.11202645
53	MP0001853_heart_inflammation	1.09870487
54	MP0005084_abnormal_gallbladder_morpholo	1.09646660
55	MP0006036_abnormal_mitochondrial_physio	1.07730632
56	MP0001440_abnormal_grooming_behavior	1.05350988
57	MP0003718_maternal_effect	1.04533483
58	MP0003122_maternal_imprinting	1.04048752
59	MP0006276_abnormal_autonomic_nervous	1.03738777
60	MP0001919_abnormal_reproductive_system	1.03435552
61	MP0003186_abnormal_redox_activity	1.03395858
62	MP0009765_abnormal_xenobiotic_induced	1.03341782
63	MP0001293_anophthalmia	1.02819928
64	MP0003121_genomic_imprinting	1.01244842
65	MP0002272_abnormal_nervous_system	1.00161942
66	MP0005000_abnormal_immune_tolerance	0.99326498
67	MP0005394_taste/olfaction_phenotype	0.97169794
68	MP0005499_abnormal_olfactory_system	0.97169794
69	MP0001501_abnormal_sleep_pattern	0.94463840
70	MP0005174_abnormal_tail_pigmentation	0.94452370
71	MP0001485_abnormal_pinna_reflex	0.94367271
72	MP0002723_abnormal_immune_serum	0.93453293
73	MP0002938_white_spotting	0.91800176
74	MP0004043_abnormal_pH_regulation	0.91065978
75	MP0002751_abnormal_autonomic_nervous	0.91029447
76	MP0003866_abnormal_defecation	0.89647382
77	MP0002653_abnormal_ependyma_morphology	0.89466207
78	MP0000427_abnormal_hair_cycle	0.87676582
79	MP0002452_abnormal_antigen_presenting	0.85840175
80	MP0001986_abnormal_taste_sensitivity	0.85282155
81	MP0008775_abnormal_heart_ventricle	0.84367778
82	MP0005253_abnormal_eye_physiology	0.82141863
83	MP0002184_abnormal_innervation	0.81070455
84	MP0005636_abnormal_mineral_homeostasis	0.80748241
85	MP0001819_abnormal_immune_cell	0.80574185
86	MP0005379_endocrine/exocrine_gland_phen	0.79768553
87	MP0002420_abnormal_adaptive_immunity	0.79222129
88	MP0002876_abnormal_thyroid_physiology	0.75747970
89	MP0003880_abnormal_central_pattern	0.75602272
90	MP0005085_abnormal_gallbladder_physiolo	0.75261409
91	MP0000049_abnormal_middle_ear	0.74983066
92	MP0005332_abnormal_amino_acid	0.74043139
93	MP0001970_abnormal_pain_threshold	0.73814900
94	MP0000689_abnormal_spleen_morphology	0.73754495
95	MP0002006_tumorigenesis	0.71591612
96	MP0009333_abnormal_splenocyte_physiolog	0.71412207
97	MP0005025_abnormal_response_to	0.71020295
98	MP0006035_abnormal_mitochondrial_morpho	0.68667442
99	MP0009745_abnormal_behavioral_response	0.68445251
100	MP0002557_abnormal_social/conspecific_i	0.67415358

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.71851855
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.02034511
3	Reticulocytopenia (HP:0001896)	3.99283348
4	Acute encephalopathy (HP:0006846)	3.98593553
5	Stomatitis (HP:0010280)	3.94432836
6	Mitochondrial inheritance (HP:0001427)	3.83502689
7	Progressive macrocephaly (HP:0004481)	3.73980242
8	Increased CSF lactate (HP:0002490)	3.71413636
9	Increased hepatocellular lipid droplets (HP:0006565)	3.59161530
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.56869830
11	Lipid accumulation in hepatocytes (HP:0006561)	3.43203136
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.33308857
13	Methylmalonic acidemia (HP:0002912)	3.30467641
14	Abnormality of DNA repair (HP:0003254)	3.26114780
15	Abnormal number of erythroid precursors (HP:0012131)	3.04143379
16	Macrocytic anemia (HP:0001972)	2.93887086
17	IgG deficiency (HP:0004315)	2.92314690
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.91794874
19	Optic disc pallor (HP:0000543)	2.88197620
20	Molar tooth sign on MRI (HP:0002419)	2.88090145
21	Abnormality of midbrain morphology (HP:0002418)	2.88090145
22	Cerebral edema (HP:0002181)	2.85307140
23	Congenital stationary night blindness (HP:0007642)	2.84555258
24	Hepatocellular necrosis (HP:0001404)	2.79075279
25	Pancreatic cysts (HP:0001737)	2.79003275
26	Exertional dyspnea (HP:0002875)	2.74829848
27	Nephronophthisis (HP:0000090)	2.74352162
28	Constricted visual fields (HP:0001133)	2.72560579
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.72506766
30	Methylmalonic aciduria (HP:0012120)	2.71953964
31	Hepatic necrosis (HP:0002605)	2.67934573
32	Increased serum lactate (HP:0002151)	2.67193163
33	Congenital, generalized hypertrichosis (HP:0004540)	2.66274576
34	Renal Fanconi syndrome (HP:0001994)	2.64779573
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.61386718
36	Asplenia (HP:0001746)	2.56648485
37	Stenosis of the external auditory canal (HP:0000402)	2.45393793
38	Pancreatic fibrosis (HP:0100732)	2.44324608
39	Abnormality of the renal cortex (HP:0011035)	2.42216077
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.36984385
41	Type II lissencephaly (HP:0007260)	2.36656217
42	Absent thumb (HP:0009777)	2.33097424
43	Increased intramyocellular lipid droplets (HP:0012240)	2.32689411
44	Colon cancer (HP:0003003)	2.30340378
45	Abnormality of the renal medulla (HP:0100957)	2.27143001
46	Pallor (HP:0000980)	2.25940256
47	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.24358909
48	Hypoproteinemia (HP:0003075)	2.20810502
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.19069438
50	Lactic acidosis (HP:0003128)	2.13883207
51	Leukodystrophy (HP:0002415)	2.12346770
52	Chronic bronchitis (HP:0004469)	2.10408404
53	Exercise intolerance (HP:0003546)	2.07967068
54	Abolished electroretinogram (ERG) (HP:0000550)	2.07452527
55	Severe combined immunodeficiency (HP:0004430)	2.06396421
56	Abnormality of the pons (HP:0007361)	2.04999455
57	Hypoplasia of the pons (HP:0012110)	2.04719199
58	Polydipsia (HP:0001959)	2.04008061
59	Abnormal drinking behavior (HP:0030082)	2.04008061
60	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.03481895
61	Tubular atrophy (HP:0000092)	2.03188547
62	3-Methylglutaconic aciduria (HP:0003535)	2.02475305
63	True hermaphroditism (HP:0010459)	1.99869548
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.99154998
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.99154998
66	Respiratory difficulties (HP:0002880)	1.98312829
67	Abnormality of urine glucose concentration (HP:0011016)	1.96829502
68	Glycosuria (HP:0003076)	1.96829502
69	Lethargy (HP:0001254)	1.95646441
70	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.94065735
71	Increased muscle lipid content (HP:0009058)	1.93892833
72	Pendular nystagmus (HP:0012043)	1.92859126
73	Abnormality of vitamin B metabolism (HP:0004340)	1.92569686
74	Attenuation of retinal blood vessels (HP:0007843)	1.92323808
75	Renal cortical cysts (HP:0000803)	1.92182876
76	Testicular atrophy (HP:0000029)	1.90407613
77	Reduced antithrombin III activity (HP:0001976)	1.90061994
78	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.89756463
79	Panhypogammaglobulinemia (HP:0003139)	1.89626964
80	Triphalangeal thumb (HP:0001199)	1.81408971
81	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.81191344
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80887431
83	Type I transferrin isoform profile (HP:0003642)	1.80568627
84	Adactyly (HP:0009776)	1.79280114
85	Respiratory failure (HP:0002878)	1.78753678
86	Medial flaring of the eyebrow (HP:0010747)	1.78707401
87	Increased IgM level (HP:0003496)	1.78523380
88	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76614307
89	Hypoplasia of the ulna (HP:0003022)	1.76435375
90	Abnormality of the renal collecting system (HP:0004742)	1.75312966
91	Abnormality of macular pigmentation (HP:0008002)	1.74611222
92	Abnormal hemoglobin (HP:0011902)	1.72624044
93	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.71855112
94	Delayed CNS myelination (HP:0002188)	1.70361367
95	Hyperphosphaturia (HP:0003109)	1.69820674
96	Papilledema (HP:0001085)	1.69564975
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68867412
98	Polyuria (HP:0000103)	1.67988454
99	Thyroiditis (HP:0100646)	1.66388215
100	Hyperglycinemia (HP:0002154)	1.65110774

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.08489512
2	VRK2	2.65521359
3	CDK19	2.56449512
4	EIF2AK3	2.54276883
5	TRIM28	2.47297497
6	GRK1	2.44865340
7	TLK1	2.36164480
8	MST4	2.26566330
9	ADRBK2	2.22371926
10	ZAK	2.12606733
11	MAP4K2	2.12139517
12	BMPR1B	2.11576372
13	TIE1	2.08941000
14	TAOK3	1.90944599
15	WNK4	1.85674567
16	OXSR1	1.78433148
17	TEC	1.74867540
18	STK16	1.72505431
19	TXK	1.65545099
20	NME1	1.62751224
21	PASK	1.60678904
22	KIT	1.54664016
23	DYRK2	1.54330415
24	WNK3	1.52598967
25	IKBKB	1.52271981
26	PBK	1.49364224
27	TSSK6	1.49225576
28	VRK1	1.42297196
29	TGFBR1	1.40774258
30	MAP2K6	1.36767718
31	MKNK2	1.33191043
32	EIF2AK1	1.31237887
33	TRPM7	1.29285234
34	FRK	1.26283612
35	ITK	1.18366594
36	PINK1	1.14700785
37	PDK2	1.10658422
38	NME2	1.09794644
39	EIF2AK2	1.07644077
40	CAMKK2	1.04149554
41	CDK8	1.01713935
42	IKBKE	1.00992094
43	SRPK1	1.00810799
44	PLK4	0.98730650
45	ADRBK1	0.98496598
46	MKNK1	0.97478679
47	PLK3	0.96894441
48	MAP3K12	0.96797025
49	STK39	0.93464576
50	FLT3	0.92618536
51	DAPK2	0.86967328
52	ACVR1B	0.85661275
53	MAP4K1	0.81968772
54	INSRR	0.77581479
55	CSNK1G2	0.76535065
56	IRAK1	0.75029225
57	BCKDK	0.74808462
58	MAPK13	0.74583956
59	ILK	0.73806558
60	GRK7	0.73131777
61	MATK	0.72592209
62	RPS6KA5	0.70774153
63	TAF1	0.70395490
64	MYLK	0.70375938
65	NEK1	0.69834788
66	TNIK	0.67367364
67	PIK3CA	0.66432693
68	PRKCG	0.64755397
69	SYK	0.59882919
70	GRK5	0.59673945
71	PRKCE	0.57603305
72	BTK	0.57381251
73	PLK2	0.57120761
74	PAK3	0.54500372
75	DAPK3	0.54139272
76	PHKG2	0.53726945
77	PHKG1	0.53726945
78	KDR	0.53311489
79	CAMK1	0.52508023
80	PIK3CG	0.52305954
81	CSNK1G3	0.51573174
82	CSNK2A2	0.50999352
83	CSNK1G1	0.50038989
84	PRKCQ	0.49108335
85	STK38L	0.48282612
86	RPS6KA6	0.46896649
87	IGF1R	0.44981335
88	LYN	0.44702059
89	RPS6KB2	0.44534140
90	CHUK	0.43202216
91	CSNK2A1	0.42835075
92	OBSCN	0.41181134
93	ATR	0.40113797
94	PRKACA	0.39627205
95	NLK	0.39505219
96	PRKCD	0.38533383
97	DAPK1	0.38164552
98	LCK	0.36989519
99	PRKCA	0.36835915
100	CAMKK1	0.33730612

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.41674709
2	Asthma_Homo sapiens_hsa05310	3.65793271
3	Protein export_Homo sapiens_hsa03060	3.35544405
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.31278638
5	Allograft rejection_Homo sapiens_hsa05330	3.09159093
6	Proteasome_Homo sapiens_hsa03050	3.04735078
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.88019072
8	Parkinsons disease_Homo sapiens_hsa05012	2.62565210
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.58964104
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29451622
11	RNA polymerase_Homo sapiens_hsa03020	2.26939995
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.24458169
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17571304
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15566793
15	RNA degradation_Homo sapiens_hsa03018	2.10579511
16	Graft-versus-host disease_Homo sapiens_hsa05332	2.02528444
17	Huntingtons disease_Homo sapiens_hsa05016	1.81179857
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.74803012
19	Alzheimers disease_Homo sapiens_hsa05010	1.68467916
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63587795
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.59585872
22	Basal transcription factors_Homo sapiens_hsa03022	1.57612269
23	Propanoate metabolism_Homo sapiens_hsa00640	1.49784195
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43561220
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.42060658
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38157592
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35666730
28	RNA transport_Homo sapiens_hsa03013	1.32332675
29	Phototransduction_Homo sapiens_hsa04744	1.25728210
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.24212840
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.24187793
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.17315701
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12489088
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12201176
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08248830
36	Homologous recombination_Homo sapiens_hsa03440	1.07784741
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05839564
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05062794
39	One carbon pool by folate_Homo sapiens_hsa00670	1.04513033
40	Spliceosome_Homo sapiens_hsa03040	1.02477338
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00426130
42	Butanoate metabolism_Homo sapiens_hsa00650	1.00102241
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97172212
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.93930763
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92834435
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90535737
47	Purine metabolism_Homo sapiens_hsa00230	0.83881564
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.82764196
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.82591995
50	Olfactory transduction_Homo sapiens_hsa04740	0.82090778
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74577582
52	Caffeine metabolism_Homo sapiens_hsa00232	0.74506744
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73875920
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.71483578
55	Peroxisome_Homo sapiens_hsa04146	0.71404022
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64887460
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64411241
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63974696
59	Mismatch repair_Homo sapiens_hsa03430	0.61164694
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.60269583
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60090923
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.56720185
63	Viral myocarditis_Homo sapiens_hsa05416	0.56495541
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55985375
65	Retinol metabolism_Homo sapiens_hsa00830	0.51541723
66	Metabolic pathways_Homo sapiens_hsa01100	0.51487391
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50892115
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49978947
69	Sulfur metabolism_Homo sapiens_hsa00920	0.49507681
70	Base excision repair_Homo sapiens_hsa03410	0.48474031
71	DNA replication_Homo sapiens_hsa03030	0.47149757
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45437574
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44604743
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44382736
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41321595
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40631124
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40491110
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39556658
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.39179304
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37506228
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36873806
82	Nicotine addiction_Homo sapiens_hsa05033	0.36393442
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36098809
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.35008538
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34991221
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34353358
87	Regulation of autophagy_Homo sapiens_hsa04140	0.34071981
88	African trypanosomiasis_Homo sapiens_hsa05143	0.33091505
89	Salivary secretion_Homo sapiens_hsa04970	0.32343451
90	Taste transduction_Homo sapiens_hsa04742	0.31756508
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31389294
92	Mineral absorption_Homo sapiens_hsa04978	0.30388550
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.29497207
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28555430
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.27776921
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.27365087
97	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.27264398
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25340009
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24688326
100	Morphine addiction_Homo sapiens_hsa05032	0.24634215

RPS3AP43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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