ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.10774022
2	viral transcription (GO:0019083)	6.75985165
3	translational termination (GO:0006415)	6.51387413
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.63016937
5	ribosomal large subunit biogenesis (GO:0042273)	5.57949409
6	cotranslational protein targeting to membrane (GO:0006613)	5.54046088
7	translational elongation (GO:0006414)	5.53306991
8	protein targeting to ER (GO:0045047)	5.49794130
9	ribosomal small subunit biogenesis (GO:0042274)	5.37412610
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.26795646
11	protein localization to endoplasmic reticulum (GO:0070972)	5.21020555
12	ATP synthesis coupled proton transport (GO:0015986)	5.19882892
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.19882892
14	cellular protein complex disassembly (GO:0043624)	4.87712335
15	maturation of SSU-rRNA (GO:0030490)	4.86473149
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.78655948
17	viral life cycle (GO:0019058)	4.73547966
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.72815081
19	chaperone-mediated protein transport (GO:0072321)	4.70000745
20	protein neddylation (GO:0045116)	4.69966305
21	translational initiation (GO:0006413)	4.54434657
22	DNA deamination (GO:0045006)	4.39866098
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.29453655
24	protein complex biogenesis (GO:0070271)	4.22873429
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.12553628
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.10649628
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.10649628
28	NADH dehydrogenase complex assembly (GO:0010257)	4.10649628
29	protein complex disassembly (GO:0043241)	4.04565308
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.92911105
31	translation (GO:0006412)	3.92088061
32	macromolecular complex disassembly (GO:0032984)	3.89315332
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.85472836
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.82061178
35	termination of RNA polymerase III transcription (GO:0006386)	3.82061178
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.81877165
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.81224834
38	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.76659508
39	GTP biosynthetic process (GO:0006183)	3.73761601
40	behavioral response to nicotine (GO:0035095)	3.73509045
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.66731745
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.66731745
43	protein polyglutamylation (GO:0018095)	3.64749149
44	respiratory electron transport chain (GO:0022904)	3.64533761
45	electron transport chain (GO:0022900)	3.63249820
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.59845020
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.57851371
48	protein targeting to membrane (GO:0006612)	3.56109820
49	base-excision repair, AP site formation (GO:0006285)	3.55257579
50	cellular component biogenesis (GO:0044085)	3.51497658
51	ribonucleoprotein complex biogenesis (GO:0022613)	3.46656980
52	mRNA catabolic process (GO:0006402)	3.39514892
53	UTP biosynthetic process (GO:0006228)	3.16849433
54	axoneme assembly (GO:0035082)	3.12367529
55	pyrimidine nucleotide catabolic process (GO:0006244)	3.08162642
56	RNA catabolic process (GO:0006401)	3.08084238
57	rRNA metabolic process (GO:0016072)	3.07269633
58	rRNA processing (GO:0006364)	3.06175297
59	proteasome assembly (GO:0043248)	3.03418947
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.02012774
61	UTP metabolic process (GO:0046051)	2.99878446
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.99663197
63	regulation of cilium movement (GO:0003352)	2.98895194
64	somite development (GO:0061053)	2.97533345
65	cell proliferation in forebrain (GO:0021846)	2.95597625
66	chromatin remodeling at centromere (GO:0031055)	2.81807506
67	ATP biosynthetic process (GO:0006754)	2.79355250
68	hydrogen ion transmembrane transport (GO:1902600)	2.78762934
69	forebrain morphogenesis (GO:0048853)	2.77337720
70	CTP metabolic process (GO:0046036)	2.74786688
71	CTP biosynthetic process (GO:0006241)	2.74786688
72	negative regulation of telomere maintenance (GO:0032205)	2.70905424
73	response to pheromone (GO:0019236)	2.70257090
74	rRNA catabolic process (GO:0016075)	2.69567865
75	rRNA modification (GO:0000154)	2.69309062
76	parturition (GO:0007567)	2.68447215
77	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.66442439
78	piRNA metabolic process (GO:0034587)	2.66149728
79	intracellular protein transmembrane import (GO:0044743)	2.62140919
80	organelle disassembly (GO:1903008)	2.61983791
81	cytochrome complex assembly (GO:0017004)	2.61363749
82	aldehyde catabolic process (GO:0046185)	2.60830215
83	male meiosis I (GO:0007141)	2.60602482
84	tRNA processing (GO:0008033)	2.59905277
85	proton transport (GO:0015992)	2.59617991
86	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59300369
87	respiratory chain complex IV assembly (GO:0008535)	2.59096809
88	regulation of microtubule-based movement (GO:0060632)	2.58026821
89	spliceosomal complex assembly (GO:0000245)	2.57572596
90	platelet dense granule organization (GO:0060155)	2.56337698
91	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.56015608
92	replication fork processing (GO:0031297)	2.55247710
93	hydrogen transport (GO:0006818)	2.55146910
94	epithelial cilium movement (GO:0003351)	2.54634278
95	pseudouridine synthesis (GO:0001522)	2.54268055
96	indolalkylamine metabolic process (GO:0006586)	2.51804548
97	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.50834005
98	indole-containing compound catabolic process (GO:0042436)	2.46148263
99	indolalkylamine catabolic process (GO:0046218)	2.46148263
100	tryptophan catabolic process (GO:0006569)	2.46148263

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.11665291
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.98573699
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56103991
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.51752998
5	VDR_22108803_ChIP-Seq_LS180_Human	3.16297364
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09622701
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.84415597
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.78143373
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67827260
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61341352
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.59999997
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.55176364
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.42098233
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.23848918
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15456539
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.13927752
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13505019
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06674616
19	MYC_18940864_ChIP-ChIP_HL60_Human	2.01480024
20	FUS_26573619_Chip-Seq_HEK293_Human	1.97346108
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.95692719
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89080632
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83672238
24	EWS_26573619_Chip-Seq_HEK293_Human	1.80820523
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78773302
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74171944
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69574255
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69305514
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.63685970
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56731923
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.56465533
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.54150662
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53300940
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51560740
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.50008237
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49873705
37	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.48165102
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48155202
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46384397
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37369929
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35335282
42	P300_19829295_ChIP-Seq_ESCs_Human	1.33779290
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28779278
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26714991
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24403394
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24403394
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24262499
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.23915422
49	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23169964
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18821753
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.18046742
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17290324
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.15729412
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15729412
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15229141
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14396256
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13648416
58	NCOR_22424771_ChIP-Seq_293T_Human	1.12971651
59	AR_20517297_ChIP-Seq_VCAP_Human	1.10820337
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10325011
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08820336
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08820336
63	GBX2_23144817_ChIP-Seq_PC3_Human	1.08713970
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08625099
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07525253
66	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06926272
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06460361
68	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06359078
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03907160
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03691864
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02862193
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02753086
73	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.00501993
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99818820
75	BCAT_22108803_ChIP-Seq_LS180_Human	0.99044223
76	TAF15_26573619_Chip-Seq_HEK293_Human	0.98973958
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.98579068
78	GABP_19822575_ChIP-Seq_HepG2_Human	0.98576262
79	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97978744
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97138054
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97044035
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95582680
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94528678
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94452899
85	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94405455
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.92920526
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92323366
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.90674946
89	ERA_21632823_ChIP-Seq_H3396_Human	0.90242634
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90188805
91	XRN2_22483619_ChIP-Seq_HELA_Human	0.89736615
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89697183
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88867601
94	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.88839945
95	REST_21632747_ChIP-Seq_MESCs_Mouse	0.88557163
96	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.88052217
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87632164
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87159005
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.86900564
100	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.85743609

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.48885632
2	MP0006292_abnormal_olfactory_placode	5.13992263
3	MP0008877_abnormal_DNA_methylation	2.73443884
4	MP0003787_abnormal_imprinting	2.72206888
5	MP0003646_muscle_fatigue	2.30707841
6	MP0006072_abnormal_retinal_apoptosis	2.05080383
7	MP0005084_abnormal_gallbladder_morpholo	2.04538326
8	MP0002163_abnormal_gland_morphology	2.03303989
9	MP0002837_dystrophic_cardiac_calcinosis	2.02114687
10	MP0002102_abnormal_ear_morphology	2.00975904
11	MP0005646_abnormal_pituitary_gland	1.98014226
12	MP0003122_maternal_imprinting	1.94659590
13	MP0004142_abnormal_muscle_tone	1.91244319
14	MP0003121_genomic_imprinting	1.89707526
15	MP0008872_abnormal_physiological_respon	1.84906233
16	MP0001293_anophthalmia	1.83951278
17	MP0001986_abnormal_taste_sensitivity	1.77616449
18	MP0008058_abnormal_DNA_repair	1.76305455
19	MP0004147_increased_porphyrin_level	1.76263584
20	MP0004885_abnormal_endolymph	1.75806506
21	MP0005551_abnormal_eye_electrophysiolog	1.73775559
22	MP0002653_abnormal_ependyma_morphology	1.71710012
23	MP0002160_abnormal_reproductive_system	1.70962262
24	MP0005645_abnormal_hypothalamus_physiol	1.68949816
25	MP0008789_abnormal_olfactory_epithelium	1.65060953
26	MP0006276_abnormal_autonomic_nervous	1.60568746
27	MP0002876_abnormal_thyroid_physiology	1.59573677
28	MP0001968_abnormal_touch/_nociception	1.59389995
29	MP0000049_abnormal_middle_ear	1.56641204
30	MP0005389_reproductive_system_phenotype	1.48608531
31	MP0002272_abnormal_nervous_system	1.47012893
32	MP0002638_abnormal_pupillary_reflex	1.44968093
33	MP0000631_abnormal_neuroendocrine_gland	1.44661705
34	MP0003283_abnormal_digestive_organ	1.43022785
35	MP0002736_abnormal_nociception_after	1.40852824
36	MP0002138_abnormal_hepatobiliary_system	1.37071996
37	MP0003123_paternal_imprinting	1.30818090
38	MP0000372_irregular_coat_pigmentation	1.30618138
39	MP0001984_abnormal_olfaction	1.30306540
40	MP0004145_abnormal_muscle_electrophysio	1.24540197
41	MP0003567_abnormal_fetal_cardiomyocyte	1.22934769
42	MP0002938_white_spotting	1.22546244
43	MP0001485_abnormal_pinna_reflex	1.22302145
44	MP0005379_endocrine/exocrine_gland_phen	1.19459107
45	MP0003011_delayed_dark_adaptation	1.19365763
46	MP0001873_stomach_inflammation	1.17828153
47	MP0005075_abnormal_melanosome_morpholog	1.17497822
48	MP0001529_abnormal_vocalization	1.17212420
49	MP0005377_hearing/vestibular/ear_phenot	1.17074338
50	MP0003878_abnormal_ear_physiology	1.17074338
51	MP0003693_abnormal_embryo_hatching	1.15300221
52	MP0005671_abnormal_response_to	1.13332260
53	MP0005499_abnormal_olfactory_system	1.13155305
54	MP0005394_taste/olfaction_phenotype	1.13155305
55	MP0001348_abnormal_lacrimal_gland	1.12539742
56	MP0001919_abnormal_reproductive_system	1.11460571
57	MP0004133_heterotaxia	1.09428418
58	MP0008875_abnormal_xenobiotic_pharmacok	1.09316662
59	MP0001440_abnormal_grooming_behavior	1.06892637
60	MP0001486_abnormal_startle_reflex	1.04158225
61	MP0005253_abnormal_eye_physiology	1.02309033
62	MP0003880_abnormal_central_pattern	1.02264282
63	MP0005360_urolithiasis	1.00490839
64	MP0009745_abnormal_behavioral_response	1.00453670
65	MP0001970_abnormal_pain_threshold	0.99844803
66	MP0005195_abnormal_posterior_eye	0.99815945
67	MP0003718_maternal_effect	0.99754324
68	MP0002735_abnormal_chemical_nociception	0.98478670
69	MP0001835_abnormal_antigen_presentation	0.96642158
70	MP0002210_abnormal_sex_determination	0.96345901
71	MP0001188_hyperpigmentation	0.95860998
72	MP0002557_abnormal_social/conspecific_i	0.94963983
73	MP0004742_abnormal_vestibular_system	0.94930140
74	MP0002733_abnormal_thermal_nociception	0.93555978
75	MP0000778_abnormal_nervous_system	0.93457305
76	MP0008995_early_reproductive_senescence	0.93254801
77	MP0003186_abnormal_redox_activity	0.88307255
78	MP0002928_abnormal_bile_duct	0.88179648
79	MP0000026_abnormal_inner_ear	0.87331447
80	MP0002752_abnormal_somatic_nervous	0.86824795
81	MP0002234_abnormal_pharynx_morphology	0.86477078
82	MP0001905_abnormal_dopamine_level	0.86273301
83	MP0003786_premature_aging	0.84537573
84	MP0001963_abnormal_hearing_physiology	0.83215728
85	MP0002184_abnormal_innervation	0.82568484
86	MP0002572_abnormal_emotion/affect_behav	0.80251682
87	MP0001502_abnormal_circadian_rhythm	0.78701893
88	MP0006036_abnormal_mitochondrial_physio	0.78669970
89	MP0001929_abnormal_gametogenesis	0.76761948
90	MP0003938_abnormal_ear_development	0.75726260
91	MP0000230_abnormal_systemic_arterial	0.74954894
92	MP0003937_abnormal_limbs/digits/tail_de	0.74524273
93	MP0001145_abnormal_male_reproductive	0.73404980
94	MP0001790_abnormal_immune_system	0.72600602
95	MP0005387_immune_system_phenotype	0.72600602
96	MP0002233_abnormal_nose_morphology	0.71667323
97	MP0000653_abnormal_sex_gland	0.69971025
98	MP0000427_abnormal_hair_cycle	0.67855282
99	MP0003698_abnormal_male_reproductive	0.66683556
100	MP0001663_abnormal_digestive_system	0.65136778

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.29075386
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.18226886
3	Reticulocytopenia (HP:0001896)	3.96699951
4	Abnormality of midbrain morphology (HP:0002418)	3.81367515
5	Molar tooth sign on MRI (HP:0002419)	3.81367515
6	Mitochondrial inheritance (HP:0001427)	3.66852467
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.64199274
8	Acute encephalopathy (HP:0006846)	3.62672599
9	Progressive macrocephaly (HP:0004481)	3.47982163
10	Macrocytic anemia (HP:0001972)	3.41058606
11	Increased CSF lactate (HP:0002490)	3.37360477
12	Nephronophthisis (HP:0000090)	3.36883644
13	Congenital stationary night blindness (HP:0007642)	3.36836395
14	3-Methylglutaconic aciduria (HP:0003535)	3.29716619
15	Abnormal number of erythroid precursors (HP:0012131)	3.29300456
16	Pancreatic fibrosis (HP:0100732)	3.28338151
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.26625715
18	Pancreatic cysts (HP:0001737)	3.17151060
19	Hepatocellular necrosis (HP:0001404)	3.07189809
20	Increased hepatocellular lipid droplets (HP:0006565)	3.06831166
21	Abnormal rod and cone electroretinograms (HP:0008323)	3.01879030
22	Lipid accumulation in hepatocytes (HP:0006561)	2.97083530
23	Abnormality of the renal medulla (HP:0100957)	2.87413010
24	Optic disc pallor (HP:0000543)	2.81168339
25	Hepatic necrosis (HP:0002605)	2.78009448
26	Stenosis of the external auditory canal (HP:0000402)	2.70021655
27	Medial flaring of the eyebrow (HP:0010747)	2.69826572
28	Asplenia (HP:0001746)	2.64359670
29	Pallor (HP:0000980)	2.61973280
30	Septo-optic dysplasia (HP:0100842)	2.60338386
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.56501713
32	Cerebral edema (HP:0002181)	2.55437673
33	Abolished electroretinogram (ERG) (HP:0000550)	2.51351534
34	Absent thumb (HP:0009777)	2.48683009
35	Colon cancer (HP:0003003)	2.48094421
36	Renal Fanconi syndrome (HP:0001994)	2.43899520
37	True hermaphroditism (HP:0010459)	2.42966605
38	Pendular nystagmus (HP:0012043)	2.41418903
39	Abnormality of the renal cortex (HP:0011035)	2.41371786
40	Increased serum lactate (HP:0002151)	2.35873886
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.35571270
42	Absent/shortened dynein arms (HP:0200106)	2.35571270
43	Abnormality of the labia minora (HP:0012880)	2.34958856
44	Exertional dyspnea (HP:0002875)	2.31289536
45	Congenital, generalized hypertrichosis (HP:0004540)	2.30224937
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20742084
47	Supernumerary spleens (HP:0009799)	2.19561480
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.19190092
49	Abnormal respiratory epithelium morphology (HP:0012253)	2.19190092
50	Hyperglycinemia (HP:0002154)	2.15350384
51	Rib fusion (HP:0000902)	2.09178844
52	Lactic acidosis (HP:0003128)	2.08939265
53	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.06042925
54	Attenuation of retinal blood vessels (HP:0007843)	2.05913653
55	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.05462473
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04721935
57	Abnormal ciliary motility (HP:0012262)	2.04704155
58	Sclerocornea (HP:0000647)	2.03670435
59	Bile duct proliferation (HP:0001408)	2.01970019
60	Abnormal biliary tract physiology (HP:0012439)	2.01970019
61	Decreased central vision (HP:0007663)	1.99636915
62	Abnormal drinking behavior (HP:0030082)	1.98399750
63	Polydipsia (HP:0001959)	1.98399750
64	Methylmalonic acidemia (HP:0002912)	1.98243713
65	Gait imbalance (HP:0002141)	1.96721341
66	Constricted visual fields (HP:0001133)	1.94944746
67	Increased intramyocellular lipid droplets (HP:0012240)	1.94554568
68	Lethargy (HP:0001254)	1.91759543
69	Oligodactyly (hands) (HP:0001180)	1.91621611
70	Tubular atrophy (HP:0000092)	1.91157248
71	Congenital primary aphakia (HP:0007707)	1.90785761
72	Abnormality of macular pigmentation (HP:0008002)	1.90747686
73	Dyschromatopsia (HP:0007641)	1.89148140
74	IgG deficiency (HP:0004315)	1.88723061
75	Cystic liver disease (HP:0006706)	1.87715474
76	Type 2 muscle fiber atrophy (HP:0003554)	1.86875824
77	Glycosuria (HP:0003076)	1.86863534
78	Abnormality of urine glucose concentration (HP:0011016)	1.86863534
79	Triphalangeal thumb (HP:0001199)	1.85876241
80	Growth hormone deficiency (HP:0000824)	1.85208812
81	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.85143192
82	Abnormality of renal resorption (HP:0011038)	1.84517961
83	Median cleft lip (HP:0000161)	1.84468086
84	Renal cortical cysts (HP:0000803)	1.84004138
85	Respiratory failure (HP:0002878)	1.83912203
86	Optic nerve hypoplasia (HP:0000609)	1.82017330
87	Polyuria (HP:0000103)	1.81990421
88	Abnormal respiratory motile cilium physiology (HP:0012261)	1.81825279
89	Type II lissencephaly (HP:0007260)	1.81781258
90	Anencephaly (HP:0002323)	1.80892463
91	Chronic hepatic failure (HP:0100626)	1.77028072
92	Nephrogenic diabetes insipidus (HP:0009806)	1.75923651
93	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.75204162
94	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74486979
95	Methylmalonic aciduria (HP:0012120)	1.74120443
96	Hypoplasia of the radius (HP:0002984)	1.73619123
97	Postaxial foot polydactyly (HP:0001830)	1.71261093
98	Leukodystrophy (HP:0002415)	1.69691183
99	Aplastic anemia (HP:0001915)	1.69550314
100	Congenital hepatic fibrosis (HP:0002612)	1.69538807

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.00230753
2	STK16	2.92818431
3	CDK19	2.75822342
4	NUAK1	2.71595654
5	TXK	2.48528565
6	VRK2	2.47141021
7	ADRBK2	2.46160629
8	WNK4	2.41072290
9	PINK1	2.39603861
10	ZAK	2.35069963
11	TLK1	2.22381233
12	TAOK3	2.15198490
13	STK39	2.03032768
14	GRK1	1.95884422
15	TIE1	1.93611812
16	BMPR1B	1.91786211
17	DYRK2	1.84732752
18	TAF1	1.81386249
19	PBK	1.75217047
20	OXSR1	1.68304932
21	FRK	1.68089520
22	WNK3	1.65665500
23	BCKDK	1.57171257
24	VRK1	1.47758762
25	TEC	1.45405555
26	PIK3CA	1.45040569
27	CDC7	1.43855372
28	PLK4	1.25786638
29	NEK1	1.23903171
30	ACVR1B	1.23453077
31	PASK	1.17181464
32	CAMKK2	1.12444320
33	NEK2	1.08092873
34	KIT	1.07285389
35	TNIK	1.04497746
36	NLK	1.03556175
37	MAP2K6	0.99945405
38	MAP3K12	0.98729894
39	INSRR	0.97813247
40	CSNK1G1	0.92446692
41	EIF2AK3	0.87818662
42	MAPK13	0.87468951
43	ITK	0.81172080
44	CDK3	0.77483583
45	PLK3	0.75196737
46	DAPK2	0.74341452
47	RPS6KA5	0.74050684
48	MKNK1	0.73780469
49	NME2	0.71509467
50	TGFBR1	0.69897431
51	PRKCG	0.69748805
52	EPHB2	0.69133163
53	CSNK1G2	0.68703475
54	NME1	0.67090382
55	PLK1	0.66687022
56	IKBKB	0.66369256
57	BTK	0.64223113
58	PRKCQ	0.63655187
59	ILK	0.62820408
60	STK24	0.61909811
61	MST4	0.59321109
62	ADRBK1	0.58841702
63	CAMK1	0.58807963
64	BRSK2	0.58573649
65	MKNK2	0.58180548
66	CDK8	0.56980440
67	CSNK2A2	0.56909966
68	MATK	0.56839928
69	DAPK3	0.55598648
70	ABL2	0.55104601
71	CAMKK1	0.53065929
72	NTRK2	0.52140522
73	AURKB	0.51933078
74	MAP3K11	0.51182593
75	CSNK1G3	0.50955676
76	PRKACA	0.50569727
77	CSNK2A1	0.49745034
78	PRKCE	0.49153853
79	MAP2K7	0.48321743
80	RPS6KA6	0.47234248
81	RPS6KB2	0.47150351
82	SYK	0.46846557
83	SGK494	0.46826796
84	SGK223	0.46826796
85	TRIM28	0.46761682
86	SRPK1	0.45548101
87	MAPKAPK5	0.45317441
88	MAP4K1	0.44578071
89	ATR	0.44515703
90	RPS6KA4	0.42665621
91	CSNK1E	0.42247995
92	PHKG1	0.41316387
93	PHKG2	0.41316387
94	BUB1	0.40166269
95	SGK2	0.40055644
96	OBSCN	0.39840106
97	MAP3K4	0.38888803
98	PRKCH	0.38317300
99	AURKA	0.37239981
100	TSSK6	0.37076081

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.74389338
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.77542774
3	Parkinsons disease_Homo sapiens_hsa05012	3.18989037
4	RNA polymerase_Homo sapiens_hsa03020	2.89319050
5	Proteasome_Homo sapiens_hsa03050	2.86800124
6	Protein export_Homo sapiens_hsa03060	2.31607109
7	Huntingtons disease_Homo sapiens_hsa05016	2.21982786
8	Homologous recombination_Homo sapiens_hsa03440	2.15546205
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.07912404
10	Alzheimers disease_Homo sapiens_hsa05010	2.01165740
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00392265
12	Asthma_Homo sapiens_hsa05310	1.98430302
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.91078764
14	RNA degradation_Homo sapiens_hsa03018	1.86438110
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84055326
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.79614899
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77919812
18	Basal transcription factors_Homo sapiens_hsa03022	1.66719113
19	Allograft rejection_Homo sapiens_hsa05330	1.66044162
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64139289
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62524286
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61180836
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54080829
24	Phototransduction_Homo sapiens_hsa04744	1.53499966
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.41950586
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34845870
27	One carbon pool by folate_Homo sapiens_hsa00670	1.32417337
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.30035366
29	Mismatch repair_Homo sapiens_hsa03430	1.29155564
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.22882218
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.18490355
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16348079
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.11566871
34	Butanoate metabolism_Homo sapiens_hsa00650	1.09228825
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.09210039
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.06813515
37	Propanoate metabolism_Homo sapiens_hsa00640	1.06493899
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04599674
39	DNA replication_Homo sapiens_hsa03030	1.04138990
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.02565455
41	Caffeine metabolism_Homo sapiens_hsa00232	1.02166466
42	Spliceosome_Homo sapiens_hsa03040	1.01039249
43	RNA transport_Homo sapiens_hsa03013	0.93178562
44	Purine metabolism_Homo sapiens_hsa00230	0.92789953
45	Base excision repair_Homo sapiens_hsa03410	0.91146128
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89279198
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89269241
48	Peroxisome_Homo sapiens_hsa04146	0.86677940
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.85806209
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85262671
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84212927
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83409156
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82862107
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81914543
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80225198
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79257796
57	Olfactory transduction_Homo sapiens_hsa04740	0.77671183
58	Retinol metabolism_Homo sapiens_hsa00830	0.75444713
59	Nicotine addiction_Homo sapiens_hsa05033	0.75415560
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74485784
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74257459
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.73624992
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73464814
64	Regulation of autophagy_Homo sapiens_hsa04140	0.73031667
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.69207160
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.66774444
67	Metabolic pathways_Homo sapiens_hsa01100	0.66227106
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64745932
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64272356
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59634606
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.58689049
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56048938
73	Taste transduction_Homo sapiens_hsa04742	0.55285993
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54438943
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53400995
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52960193
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52888803
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49882546
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.46764929
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.44990084
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44382560
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43242102
83	Fatty acid degradation_Homo sapiens_hsa00071	0.40353279
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39996475
85	Sulfur relay system_Homo sapiens_hsa04122	0.38610680
86	Salivary secretion_Homo sapiens_hsa04970	0.37780763
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36942733
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36654433
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35030083
90	Morphine addiction_Homo sapiens_hsa05032	0.33979925
91	Fatty acid elongation_Homo sapiens_hsa00062	0.33336290
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31671901
93	Serotonergic synapse_Homo sapiens_hsa04726	0.30270440
94	Insulin secretion_Homo sapiens_hsa04911	0.29504395
95	Mineral absorption_Homo sapiens_hsa04978	0.28095364
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26703407
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.26164422
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.25518287
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25392853
100	Folate biosynthesis_Homo sapiens_hsa00790	0.24588576

RPS3AP44

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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