ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.82042093
2	viral transcription (GO:0019083)	5.58136668
3	DNA deamination (GO:0045006)	5.50628964
4	translational termination (GO:0006415)	5.37478662
5	translational elongation (GO:0006414)	4.77724063
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.76808118
7	cotranslational protein targeting to membrane (GO:0006613)	4.68026119
8	protein targeting to ER (GO:0045047)	4.65505787
9	maturation of SSU-rRNA (GO:0030490)	4.60390095
10	ATP synthesis coupled proton transport (GO:0015986)	4.58940775
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.58940775
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.52584048
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.44664083
14	protein localization to endoplasmic reticulum (GO:0070972)	4.43069784
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.36679098
16	cytidine metabolic process (GO:0046087)	4.36427132
17	cytidine catabolic process (GO:0006216)	4.36427132
18	cytidine deamination (GO:0009972)	4.36427132
19	behavioral response to nicotine (GO:0035095)	4.33581911
20	ribosomal small subunit biogenesis (GO:0042274)	4.14882406
21	protein neddylation (GO:0045116)	4.05807268
22	ribosomal large subunit biogenesis (GO:0042273)	4.04287576
23	cellular protein complex disassembly (GO:0043624)	3.99053219
24	viral life cycle (GO:0019058)	3.95748532
25	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.78353646
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.77611809
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.74219993
28	translational initiation (GO:0006413)	3.64411572
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47490525
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47490525
31	protein complex biogenesis (GO:0070271)	3.44950288
32	electron transport chain (GO:0022900)	3.36275992
33	respiratory electron transport chain (GO:0022904)	3.34588419
34	translation (GO:0006412)	3.28216643
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.27609108
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.27609108
37	NADH dehydrogenase complex assembly (GO:0010257)	3.27609108
38	protein complex disassembly (GO:0043241)	3.24301878
39	macromolecular complex disassembly (GO:0032984)	3.15615057
40	axoneme assembly (GO:0035082)	3.14940227
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04443128
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.01996800
43	protein targeting to membrane (GO:0006612)	2.99907285
44	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.99281782
45	GPI anchor metabolic process (GO:0006505)	2.97993030
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96005183
47	chaperone-mediated protein transport (GO:0072321)	2.90848832
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89903495
49	response to pheromone (GO:0019236)	2.89204223
50	GPI anchor biosynthetic process (GO:0006506)	2.86638541
51	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.84906172
52	mannosylation (GO:0097502)	2.83377594
53	water-soluble vitamin biosynthetic process (GO:0042364)	2.79431742
54	positive regulation of defense response to virus by host (GO:0002230)	2.77465443
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.77399340
56	termination of RNA polymerase III transcription (GO:0006386)	2.73722399
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.73722399
58	cellular component biogenesis (GO:0044085)	2.70239730
59	negative regulation of mast cell activation (GO:0033004)	2.70029860
60	platelet dense granule organization (GO:0060155)	2.69816856
61	hydrogen ion transmembrane transport (GO:1902600)	2.68296999
62	mRNA catabolic process (GO:0006402)	2.67575283
63	kynurenine metabolic process (GO:0070189)	2.65633901
64	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.65541505
65	GTP biosynthetic process (GO:0006183)	2.64751719
66	protein polyglutamylation (GO:0018095)	2.64279367
67	negative regulation of telomere maintenance (GO:0032205)	2.62405262
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62286494
69	ATP biosynthetic process (GO:0006754)	2.61508002
70	proton transport (GO:0015992)	2.59828567
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.59792172
72	indole-containing compound catabolic process (GO:0042436)	2.59116298
73	indolalkylamine catabolic process (GO:0046218)	2.59116298
74	tryptophan catabolic process (GO:0006569)	2.59116298
75	piRNA metabolic process (GO:0034587)	2.57339859
76	ubiquinone biosynthetic process (GO:0006744)	2.57287206
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.55785745
78	hydrogen transport (GO:0006818)	2.55281280
79	ribonucleoprotein complex biogenesis (GO:0022613)	2.54638414
80	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.54407702
81	indolalkylamine metabolic process (GO:0006586)	2.52069512
82	metallo-sulfur cluster assembly (GO:0031163)	2.51283964
83	iron-sulfur cluster assembly (GO:0016226)	2.51283964
84	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.50505614
85	mast cell activation (GO:0045576)	2.49347318
86	regulation of action potential (GO:0098900)	2.46909055
87	base-excision repair, AP site formation (GO:0006285)	2.46356758
88	mast cell degranulation (GO:0043303)	2.45731088
89	mast cell activation involved in immune response (GO:0002279)	2.45731088
90	regulation of regulatory T cell differentiation (GO:0045589)	2.44218774
91	RNA catabolic process (GO:0006401)	2.43985668
92	L-fucose catabolic process (GO:0042355)	2.43546254
93	fucose catabolic process (GO:0019317)	2.43546254
94	L-fucose metabolic process (GO:0042354)	2.43546254
95	regulation of cilium movement (GO:0003352)	2.42452380
96	regulation of isotype switching to IgG isotypes (GO:0048302)	2.39949130
97	negative regulation of appetite (GO:0032099)	2.39823958
98	negative regulation of response to food (GO:0032096)	2.39823958
99	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.38780981
100	parturition (GO:0007567)	2.38643445

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.64058298
2	VDR_22108803_ChIP-Seq_LS180_Human	3.42236532
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.40129548
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.00004230
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.76836655
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.68759179
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66713897
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.64320543
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57005929
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51824420
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16832519
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.16631848
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09973738
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00505301
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99885112
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99623436
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97612506
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97352133
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.94932739
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.91518062
21	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.91241334
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.88596870
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75321795
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.74032349
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.73891929
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71144013
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68784368
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68413053
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60250048
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.59712345
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.59366265
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56216533
33	EWS_26573619_Chip-Seq_HEK293_Human	1.55372415
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52243656
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50581971
36	FUS_26573619_Chip-Seq_HEK293_Human	1.46232070
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45444709
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43589262
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43589262
40	AR_20517297_ChIP-Seq_VCAP_Human	1.41144303
41	NCOR_22424771_ChIP-Seq_293T_Human	1.37112377
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36358962
43	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.35663831
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34057218
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33221198
46	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32958280
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28994061
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.28731271
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.28567385
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.25932166
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25932166
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25410874
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.25020350
54	P300_19829295_ChIP-Seq_ESCs_Human	1.24589849
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23662213
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21368973
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.21143190
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21101816
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19513393
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19296280
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19291644
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18925306
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18925306
64	GATA3_26560356_Chip-Seq_TH2_Human	1.18482750
65	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.17698291
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17303485
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15197168
68	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10852313
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10685347
70	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.08843982
71	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07973097
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07425620
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07291704
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05177495
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04844344
76	ERA_21632823_ChIP-Seq_H3396_Human	1.03511352
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.03385120
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02920424
79	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02163019
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01958678
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00620359
82	TAF15_26573619_Chip-Seq_HEK293_Human	1.00611624
83	GBX2_23144817_ChIP-Seq_PC3_Human	0.98125091
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96891427
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.96538930
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96212055
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95864063
88	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95778436
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.95759425
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95624610
91	MYB_26560356_Chip-Seq_TH2_Human	0.95066173
92	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94022879
93	RUNX_20019798_ChIP-Seq_JUKART_Human	0.93867246
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92884127
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92717789
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92128998
97	REST_21632747_ChIP-Seq_MESCs_Mouse	0.91132852
98	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90994985
99	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.89791493
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89746372

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.49749985
2	MP0005671_abnormal_response_to	3.52583123
3	MP0006292_abnormal_olfactory_placode	3.46762441
4	MP0006072_abnormal_retinal_apoptosis	2.29481943
5	MP0008877_abnormal_DNA_methylation	2.16869372
6	MP0001835_abnormal_antigen_presentation	2.14398937
7	MP0004147_increased_porphyrin_level	2.13147930
8	MP0002102_abnormal_ear_morphology	2.06650374
9	MP0003646_muscle_fatigue	1.94523864
10	MP0008872_abnormal_physiological_respon	1.93575337
11	MP0005551_abnormal_eye_electrophysiolog	1.90137459
12	MP0005645_abnormal_hypothalamus_physiol	1.86594067
13	MP0004142_abnormal_muscle_tone	1.86265492
14	MP0003787_abnormal_imprinting	1.85075033
15	MP0003878_abnormal_ear_physiology	1.83687502
16	MP0005377_hearing/vestibular/ear_phenot	1.83687502
17	MP0002653_abnormal_ependyma_morphology	1.78872868
18	MP0005646_abnormal_pituitary_gland	1.76605815
19	MP0002163_abnormal_gland_morphology	1.76071724
20	MP0002837_dystrophic_cardiac_calcinosis	1.74592334
21	MP0009785_altered_susceptibility_to	1.68605070
22	MP0001986_abnormal_taste_sensitivity	1.65046881
23	MP0004145_abnormal_muscle_electrophysio	1.64627615
24	MP0001968_abnormal_touch/_nociception	1.63917638
25	MP0004885_abnormal_endolymph	1.63266337
26	MP0008875_abnormal_xenobiotic_pharmacok	1.62668109
27	MP0002876_abnormal_thyroid_physiology	1.58078800
28	MP0005389_reproductive_system_phenotype	1.53009911
29	MP0005084_abnormal_gallbladder_morpholo	1.52834362
30	MP0002138_abnormal_hepatobiliary_system	1.50802070
31	MP0002160_abnormal_reproductive_system	1.44757968
32	MP0006276_abnormal_autonomic_nervous	1.44044269
33	MP0001800_abnormal_humoral_immune	1.41366800
34	MP0005075_abnormal_melanosome_morpholog	1.40189081
35	MP0000372_irregular_coat_pigmentation	1.40094127
36	MP0002272_abnormal_nervous_system	1.36342465
37	MP0008789_abnormal_olfactory_epithelium	1.34558716
38	MP0005253_abnormal_eye_physiology	1.33972960
39	MP0001873_stomach_inflammation	1.32233464
40	MP0002736_abnormal_nociception_after	1.32056874
41	MP0001485_abnormal_pinna_reflex	1.31666213
42	MP0001905_abnormal_dopamine_level	1.30678661
43	MP0002148_abnormal_hypersensitivity_rea	1.29493949
44	MP0003011_delayed_dark_adaptation	1.28289409
45	MP0005000_abnormal_immune_tolerance	1.25406434
46	MP0001919_abnormal_reproductive_system	1.24760684
47	MP0009333_abnormal_splenocyte_physiolog	1.19521653
48	MP0003880_abnormal_central_pattern	1.18388843
49	MP0002095_abnormal_skin_pigmentation	1.18346385
50	MP0002638_abnormal_pupillary_reflex	1.17452511
51	MP0002723_abnormal_immune_serum	1.16544279
52	MP0000685_abnormal_immune_system	1.15980519
53	MP0003763_abnormal_thymus_physiology	1.15021506
54	MP0001188_hyperpigmentation	1.13587700
55	MP0001293_anophthalmia	1.11322373
56	MP0003195_calcinosis	1.09779267
57	MP0001790_abnormal_immune_system	1.08753489
58	MP0005387_immune_system_phenotype	1.08753489
59	MP0009745_abnormal_behavioral_response	1.07082357
60	MP0000631_abnormal_neuroendocrine_gland	1.06956056
61	MP0002234_abnormal_pharynx_morphology	1.05365986
62	MP0005174_abnormal_tail_pigmentation	1.04884656
63	MP0002420_abnormal_adaptive_immunity	1.04609279
64	MP0001819_abnormal_immune_cell	1.02808124
65	MP0001501_abnormal_sleep_pattern	1.01548681
66	MP0003866_abnormal_defecation	1.00310962
67	MP0005379_endocrine/exocrine_gland_phen	0.99862600
68	MP0008995_early_reproductive_senescence	0.99672969
69	MP0001984_abnormal_olfaction	0.99595526
70	MP0001970_abnormal_pain_threshold	0.99564789
71	MP0001529_abnormal_vocalization	0.97633281
72	MP0002452_abnormal_antigen_presenting	0.94295804
73	MP0004742_abnormal_vestibular_system	0.94046433
74	MP0005025_abnormal_response_to	0.93498085
75	MP0003567_abnormal_fetal_cardiomyocyte	0.93096971
76	MP0009764_decreased_sensitivity_to	0.92884444
77	MP0002733_abnormal_thermal_nociception	0.90551287
78	MP0003122_maternal_imprinting	0.88442828
79	MP0005195_abnormal_posterior_eye	0.88205427
80	MP0001486_abnormal_startle_reflex	0.87172355
81	MP0002166_altered_tumor_susceptibility	0.84925070
82	MP0010386_abnormal_urinary_bladder	0.83988656
83	MP0001440_abnormal_grooming_behavior	0.82510840
84	MP0005410_abnormal_fertilization	0.82439270
85	MP0002735_abnormal_chemical_nociception	0.82092238
86	MP0002006_tumorigenesis	0.80626958
87	MP0002277_abnormal_respiratory_mucosa	0.80539377
88	MP0003121_genomic_imprinting	0.79993745
89	MP0001963_abnormal_hearing_physiology	0.78609556
90	MP0001765_abnormal_ion_homeostasis	0.78224251
91	MP0005636_abnormal_mineral_homeostasis	0.77407384
92	MP0005499_abnormal_olfactory_system	0.77178740
93	MP0005394_taste/olfaction_phenotype	0.77178740
94	MP0000049_abnormal_middle_ear	0.77154618
95	MP0000716_abnormal_immune_system	0.77060421
96	MP0003806_abnormal_nucleotide_metabolis	0.77014108
97	MP0002928_abnormal_bile_duct	0.76679427
98	MP0001348_abnormal_lacrimal_gland	0.76267076
99	MP0000026_abnormal_inner_ear	0.74315007
100	MP0003136_yellow_coat_color	0.74284799

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.36982381
2	Acute necrotizing encephalopathy (HP:0006965)	3.84380264
3	Congenital stationary night blindness (HP:0007642)	3.77537054
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.58975253
5	Reticulocytopenia (HP:0001896)	3.51170779
6	Mitochondrial inheritance (HP:0001427)	3.49780771
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.44847407
8	Pancreatic cysts (HP:0001737)	3.44029604
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.43490536
10	Abnormality of midbrain morphology (HP:0002418)	3.41438951
11	Molar tooth sign on MRI (HP:0002419)	3.41438951
12	Pancreatic fibrosis (HP:0100732)	3.32740368
13	IgG deficiency (HP:0004315)	3.24844737
14	Acute encephalopathy (HP:0006846)	3.24067449
15	Progressive macrocephaly (HP:0004481)	3.16073094
16	Increased CSF lactate (HP:0002490)	3.06418849
17	True hermaphroditism (HP:0010459)	3.03129407
18	Elevated erythrocyte sedimentation rate (HP:0003565)	3.02919250
19	Hepatocellular necrosis (HP:0001404)	3.01219799
20	Aplastic anemia (HP:0001915)	3.00224612
21	Abolished electroretinogram (ERG) (HP:0000550)	2.97380375
22	3-Methylglutaconic aciduria (HP:0003535)	2.94233674
23	Abnormal number of erythroid precursors (HP:0012131)	2.88004505
24	Severe combined immunodeficiency (HP:0004430)	2.87675163
25	Medial flaring of the eyebrow (HP:0010747)	2.74984868
26	Nephronophthisis (HP:0000090)	2.74934695
27	Hepatic necrosis (HP:0002605)	2.73288171
28	Absent/shortened dynein arms (HP:0200106)	2.63460251
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.63460251
30	Macrocytic anemia (HP:0001972)	2.63283241
31	Increased hepatocellular lipid droplets (HP:0006565)	2.60227775
32	Optic disc pallor (HP:0000543)	2.55241206
33	Type II lissencephaly (HP:0007260)	2.46428465
34	Lipid accumulation in hepatocytes (HP:0006561)	2.45423183
35	Cerebral edema (HP:0002181)	2.43134966
36	Renal Fanconi syndrome (HP:0001994)	2.43126993
37	Thyroiditis (HP:0100646)	2.39819872
38	Hypoproteinemia (HP:0003075)	2.39654316
39	Attenuation of retinal blood vessels (HP:0007843)	2.39332666
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.38367228
41	Pendular nystagmus (HP:0012043)	2.37490182
42	Asplenia (HP:0001746)	2.36590703
43	Abnormality of the renal cortex (HP:0011035)	2.36416238
44	Decreased central vision (HP:0007663)	2.33714535
45	Absent thumb (HP:0009777)	2.31653640
46	Stenosis of the external auditory canal (HP:0000402)	2.30375242
47	Abnormality of the renal medulla (HP:0100957)	2.28255864
48	Abnormality of B cell number (HP:0010975)	2.27772306
49	Stomatitis (HP:0010280)	2.26270477
50	Pallor (HP:0000980)	2.25589947
51	Constricted visual fields (HP:0001133)	2.24998823
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24575111
53	Increased intramyocellular lipid droplets (HP:0012240)	2.21830941
54	Congenital, generalized hypertrichosis (HP:0004540)	2.21608997
55	Sclerocornea (HP:0000647)	2.17786999
56	Increased IgM level (HP:0003496)	2.17515823
57	Cystic liver disease (HP:0006706)	2.16492591
58	Renal cortical cysts (HP:0000803)	2.15978777
59	Type 2 muscle fiber atrophy (HP:0003554)	2.15206279
60	T lymphocytopenia (HP:0005403)	2.13815591
61	Gait imbalance (HP:0002141)	2.11725807
62	Polydipsia (HP:0001959)	2.11541055
63	Abnormal drinking behavior (HP:0030082)	2.11541055
64	Abnormality of T cell number (HP:0011839)	2.11264492
65	Congenital primary aphakia (HP:0007707)	2.10886438
66	Increased serum lactate (HP:0002151)	2.10072120
67	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07304834
68	Abnormal respiratory epithelium morphology (HP:0012253)	2.07304834
69	Combined immunodeficiency (HP:0005387)	2.04798544
70	Methylmalonic acidemia (HP:0002912)	2.04595354
71	Abnormal respiratory motile cilium physiology (HP:0012261)	2.03141079
72	Abnormal ciliary motility (HP:0012262)	2.02559407
73	Nephrogenic diabetes insipidus (HP:0009806)	2.01179784
74	B lymphocytopenia (HP:0010976)	1.97919908
75	Generalized aminoaciduria (HP:0002909)	1.95698943
76	Septo-optic dysplasia (HP:0100842)	1.95224450
77	Lactic acidosis (HP:0003128)	1.94788393
78	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94086091
79	Abnormality of DNA repair (HP:0003254)	1.93929313
80	Abnormality of the prostate (HP:0008775)	1.92794900
81	Keratoconus (HP:0000563)	1.91158281
82	Increased corneal curvature (HP:0100692)	1.91158281
83	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.90904413
84	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.90904413
85	Rib fusion (HP:0000902)	1.89466449
86	Abnormality of T cells (HP:0002843)	1.88291134
87	Lethargy (HP:0001254)	1.87901194
88	Exertional dyspnea (HP:0002875)	1.87576340
89	Chronic hepatic failure (HP:0100626)	1.87112545
90	Panhypogammaglobulinemia (HP:0003139)	1.85501331
91	Abnormality of eosinophils (HP:0001879)	1.83810086
92	Polyuria (HP:0000103)	1.83442099
93	Increased muscle lipid content (HP:0009058)	1.82272324
94	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.81409907
95	Pancytopenia (HP:0001876)	1.79106141
96	Abnormality of the renal collecting system (HP:0004742)	1.78381777
97	Hyperglycinemia (HP:0002154)	1.74666798
98	Male pseudohermaphroditism (HP:0000037)	1.74280512
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.74045366
100	Glycosuria (HP:0003076)	1.73202090

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.36809681
2	CDK19	3.17043524
3	TAOK3	2.90586849
4	MAP4K2	2.75552899
5	ADRBK2	2.74631672
6	BCKDK	2.63533863
7	ZAK	2.63218001
8	KDR	2.53356610
9	TLK1	2.50230439
10	GRK1	2.42015251
11	NUAK1	2.22006446
12	FRK	2.11512398
13	VRK2	2.00466014
14	PINK1	1.98150896
15	WNK4	1.95352399
16	STK16	1.90531581
17	TESK2	1.85779000
18	MAP4K1	1.59801850
19	KIT	1.47314778
20	WNK3	1.45470681
21	ITK	1.37872934
22	BMPR1B	1.36967094
23	VRK1	1.33222846
24	TIE1	1.31934671
25	TEC	1.29407916
26	PASK	1.29141923
27	DYRK2	1.26463726
28	FES	1.20160357
29	MAP3K12	1.19475131
30	GRK6	1.14246045
31	OXSR1	1.10253424
32	SYK	1.08874884
33	MUSK	1.05639733
34	IKBKB	1.05367799
35	PIK3CA	1.04290739
36	INSRR	1.02327254
37	MST4	0.99939424
38	NME1	0.98547034
39	PRKCQ	0.97952755
40	STK39	0.95825956
41	FLT3	0.95753779
42	MAPK13	0.88844990
43	DAPK2	0.86665118
44	GRK7	0.83275534
45	LIMK1	0.81814026
46	IKBKE	0.81280373
47	BTK	0.79956026
48	LCK	0.79221914
49	TNK2	0.78295048
50	ADRBK1	0.77394207
51	PLK4	0.75987227
52	CSF1R	0.74501892
53	MAP3K11	0.73311630
54	CAMKK2	0.73217395
55	DAPK1	0.67825054
56	LYN	0.67764619
57	MAP2K7	0.66381200
58	OBSCN	0.63739527
59	RPS6KA5	0.62345122
60	PIM1	0.61766438
61	PRKCG	0.59395069
62	MAP3K4	0.58515565
63	MAP2K6	0.56840350
64	PRKACA	0.56215246
65	DAPK3	0.55286898
66	BMPR2	0.55181515
67	CSNK1G3	0.54241423
68	SCYL2	0.54098989
69	MYLK	0.52803357
70	CSNK1G1	0.52792745
71	CAMK1	0.52788988
72	PRKCH	0.51581843
73	MATK	0.50766260
74	PHKG2	0.50757658
75	PHKG1	0.50757658
76	PIK3CG	0.50443524
77	CDK8	0.50390611
78	MAPKAPK5	0.48652987
79	CAMKK1	0.47238156
80	PRKCA	0.46451911
81	CSNK1G2	0.45701408
82	IGF1R	0.45500575
83	RPS6KA6	0.45376801
84	CSNK2A2	0.45291874
85	MAPKAPK3	0.43753207
86	EIF2AK3	0.42451211
87	AURKA	0.41710044
88	GRK5	0.41631160
89	PRKCE	0.41029272
90	RPS6KA4	0.40942415
91	CSNK2A1	0.37661068
92	MAPK15	0.37247662
93	PRKCD	0.36241647
94	ZAP70	0.35735498
95	NTRK2	0.35465830
96	CAMK2A	0.34049087
97	TRPM7	0.33524154
98	CDC7	0.33202630
99	CSK	0.30909132
100	ILK	0.30764285

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.71451518
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.59323306
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.01786404
4	Parkinsons disease_Homo sapiens_hsa05012	2.91924600
5	Proteasome_Homo sapiens_hsa03050	2.81082556
6	Asthma_Homo sapiens_hsa05310	2.46012585
7	Allograft rejection_Homo sapiens_hsa05330	2.37200233
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.27110639
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24454558
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.20851793
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.20338293
12	RNA polymerase_Homo sapiens_hsa03020	2.11700903
13	Protein export_Homo sapiens_hsa03060	2.03981596
14	Phototransduction_Homo sapiens_hsa04744	2.02689659
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96321706
16	Alzheimers disease_Homo sapiens_hsa05010	1.93537947
17	Huntingtons disease_Homo sapiens_hsa05016	1.89976894
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89002001
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.87955211
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71468230
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66856650
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.63601132
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.57168889
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49205769
25	Homologous recombination_Homo sapiens_hsa03440	1.46965752
26	RNA degradation_Homo sapiens_hsa03018	1.40923227
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31236200
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.27978533
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23694513
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22785577
31	Caffeine metabolism_Homo sapiens_hsa00232	1.17139263
32	One carbon pool by folate_Homo sapiens_hsa00670	1.10315757
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08754095
34	Nicotine addiction_Homo sapiens_hsa05033	1.06729686
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.06323965
36	Peroxisome_Homo sapiens_hsa04146	1.04104499
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03980534
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01856019
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00357942
40	Butanoate metabolism_Homo sapiens_hsa00650	0.99361423
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99049271
42	Olfactory transduction_Homo sapiens_hsa04740	0.97461315
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97060329
44	Propanoate metabolism_Homo sapiens_hsa00640	0.97012262
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.96271172
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91667228
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89160381
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87986603
49	Basal transcription factors_Homo sapiens_hsa03022	0.87726678
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.86696131
51	Retinol metabolism_Homo sapiens_hsa00830	0.85710919
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85706846
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81819796
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81727376
55	Purine metabolism_Homo sapiens_hsa00230	0.80440087
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80114644
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.79373637
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77341799
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75116453
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73705117
61	Mismatch repair_Homo sapiens_hsa03430	0.72295599
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.69001133
63	Taste transduction_Homo sapiens_hsa04742	0.68561442
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67602446
65	Regulation of autophagy_Homo sapiens_hsa04140	0.67564042
66	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64238044
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63025828
68	DNA replication_Homo sapiens_hsa03030	0.59430009
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.58506706
70	Metabolic pathways_Homo sapiens_hsa01100	0.57720587
71	Base excision repair_Homo sapiens_hsa03410	0.57491034
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56573452
73	Morphine addiction_Homo sapiens_hsa05032	0.55760793
74	Viral myocarditis_Homo sapiens_hsa05416	0.55464065
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.55008491
76	Spliceosome_Homo sapiens_hsa03040	0.54845363
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53426872
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53293897
79	RNA transport_Homo sapiens_hsa03013	0.53238881
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52398667
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51312372
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51010674
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47764517
84	Sulfur relay system_Homo sapiens_hsa04122	0.47445523
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46309666
86	Sulfur metabolism_Homo sapiens_hsa00920	0.45799310
87	Salivary secretion_Homo sapiens_hsa04970	0.44331793
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42477593
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41831211
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38605078
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38188432
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36655975
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.29536664
94	Serotonergic synapse_Homo sapiens_hsa04726	0.29073319
95	Circadian entrainment_Homo sapiens_hsa04713	0.26644040
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26517420
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24952526
98	Fatty acid degradation_Homo sapiens_hsa00071	0.23286937
99	GABAergic synapse_Homo sapiens_hsa04727	0.22914376
100	Fatty acid elongation_Homo sapiens_hsa00062	0.22909916

RPS3AP47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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