ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.10699012
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.08243315
3	ATP synthesis coupled proton transport (GO:0015986)	5.08243315
4	viral transcription (GO:0019083)	5.07973136
5	DNA deamination (GO:0045006)	5.01133980
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.95294364
7	translational termination (GO:0006415)	4.92682616
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.46496227
9	cotranslational protein targeting to membrane (GO:0006613)	4.40622632
10	ribosomal large subunit biogenesis (GO:0042273)	4.40248834
11	protein targeting to ER (GO:0045047)	4.37406921
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.29501010
13	translational elongation (GO:0006414)	4.26824842
14	protein neddylation (GO:0045116)	4.24975814
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.19827541
16	protein localization to endoplasmic reticulum (GO:0070972)	4.16308459
17	maturation of SSU-rRNA (GO:0030490)	3.85701789
18	respiratory electron transport chain (GO:0022904)	3.79208757
19	electron transport chain (GO:0022900)	3.78108437
20	protein complex biogenesis (GO:0070271)	3.59806813
21	cellular protein complex disassembly (GO:0043624)	3.58740076
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53218942
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53218942
24	viral life cycle (GO:0019058)	3.53149948
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.52352468
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.46239294
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.43406094
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.43406094
29	NADH dehydrogenase complex assembly (GO:0010257)	3.43406094
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.43195885
31	translational initiation (GO:0006413)	3.37775099
32	platelet dense granule organization (GO:0060155)	3.36478212
33	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.33682976
34	behavioral response to nicotine (GO:0035095)	3.32534146
35	cytidine metabolic process (GO:0046087)	3.32246770
36	cytidine catabolic process (GO:0006216)	3.32246770
37	cytidine deamination (GO:0009972)	3.32246770
38	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.25565798
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.24432355
40	kynurenine metabolic process (GO:0070189)	3.23703551
41	translation (GO:0006412)	3.17206672
42	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.14419686
43	indolalkylamine catabolic process (GO:0046218)	3.14063351
44	tryptophan catabolic process (GO:0006569)	3.14063351
45	indole-containing compound catabolic process (GO:0042436)	3.14063351
46	GPI anchor metabolic process (GO:0006505)	3.11508899
47	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.11214949
48	GPI anchor biosynthetic process (GO:0006506)	3.08460125
49	ribosomal small subunit biogenesis (GO:0042274)	3.07896659
50	chaperone-mediated protein transport (GO:0072321)	3.05132977
51	indolalkylamine metabolic process (GO:0006586)	2.98168843
52	hydrogen ion transmembrane transport (GO:1902600)	2.85797103
53	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.85617722
54	protein complex disassembly (GO:0043241)	2.83405780
55	macromolecular complex disassembly (GO:0032984)	2.80582285
56	protein targeting to membrane (GO:0006612)	2.78614750
57	organelle disassembly (GO:1903008)	2.75515486
58	proton transport (GO:0015992)	2.73381202
59	aldehyde catabolic process (GO:0046185)	2.73367163
60	ATP biosynthetic process (GO:0006754)	2.72093174
61	tryptophan metabolic process (GO:0006568)	2.71368576
62	termination of RNA polymerase III transcription (GO:0006386)	2.71299056
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71299056
64	protein-cofactor linkage (GO:0018065)	2.71067993
65	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.70923857
66	negative regulation of heart rate (GO:0010459)	2.70770457
67	hydrogen transport (GO:0006818)	2.70433234
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.69065281
69	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.69035732
70	piRNA metabolic process (GO:0034587)	2.68570563
71	positive regulation of interleukin-17 production (GO:0032740)	2.68121491
72	GTP biosynthetic process (GO:0006183)	2.67221023
73	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.66390489
74	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.65697197
75	axoneme assembly (GO:0035082)	2.65601588
76	respiratory chain complex IV assembly (GO:0008535)	2.64050104
77	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.63842253
78	proteasome assembly (GO:0043248)	2.61277875
79	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.61153110
80	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.60086075
81	base-excision repair, AP site formation (GO:0006285)	2.60032053
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.56882626
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.55379413
84	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.53440757
85	mRNA catabolic process (GO:0006402)	2.52339136
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.52017968
87	detection of light stimulus involved in visual perception (GO:0050908)	2.52017968
88	negative regulation of mast cell activation (GO:0033004)	2.51714068
89	mannosylation (GO:0097502)	2.49910601
90	response to pheromone (GO:0019236)	2.48668334
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.48081561
92	cytochrome complex assembly (GO:0017004)	2.46016528
93	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.45942868
94	cellular component biogenesis (GO:0044085)	2.45636562
95	ribonucleoprotein complex disassembly (GO:0032988)	2.43594503
96	positive regulation of protein homodimerization activity (GO:0090073)	2.39638868
97	regulation of hypersensitivity (GO:0002883)	2.38186759
98	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.35862237
99	RNA catabolic process (GO:0006401)	2.31588340
100	mast cell activation (GO:0045576)	2.30494724

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.32794519
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.28521926
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.25953172
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81905498
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.61680183
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61093053
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.59257870
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.59166783
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55745173
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42565340
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26747344
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.17475121
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.14965567
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.11019945
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.09395515
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08418058
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.00583733
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91982134
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89607174
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.89463347
21	FUS_26573619_Chip-Seq_HEK293_Human	1.89381530
22	EWS_26573619_Chip-Seq_HEK293_Human	1.86456089
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.80384382
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78907157
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77662706
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.72217238
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69238797
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68356918
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.66494504
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66094125
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.65433222
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.63712054
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.62227509
34	P300_19829295_ChIP-Seq_ESCs_Human	1.56798980
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.55414513
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.55414513
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53233463
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.52909947
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52752583
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.48898310
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47826607
42	AR_20517297_ChIP-Seq_VCAP_Human	1.43533696
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41876553
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40266929
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36933306
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36933306
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.35614940
48	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.35297139
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34227370
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33310679
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32931596
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.32931596
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31701511
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29940397
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28319867
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27729932
57	NCOR_22424771_ChIP-Seq_293T_Human	1.27025686
58	GBX2_23144817_ChIP-Seq_PC3_Human	1.25479375
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24998770
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24358795
61	GATA3_26560356_Chip-Seq_TH2_Human	1.22926009
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21841011
63	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19947692
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17468316
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17232274
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16792447
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15877527
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14990678
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14673858
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14647707
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.14443098
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13870078
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08084481
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07297794
75	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.07160580
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06495080
77	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05646161
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.03792170
79	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03539901
80	ERG_20517297_ChIP-Seq_VCAP_Human	1.02504771
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01862143
82	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01768422
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00291090
84	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.00243386
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99593351
86	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.99567945
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.98738416
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95097422
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94406703
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93280026
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92474755
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92225942
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91943885
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91293464
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91135979
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89518129
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89056994
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88867821
99	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88546097
100	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.88461007

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.38279564
2	MP0006292_abnormal_olfactory_placode	3.30117234
3	MP0001835_abnormal_antigen_presentation	3.05334484
4	MP0005671_abnormal_response_to	2.96068046
5	MP0002837_dystrophic_cardiac_calcinosis	2.53599069
6	MP0006072_abnormal_retinal_apoptosis	2.29001557
7	MP0002102_abnormal_ear_morphology	2.24188520
8	MP0005646_abnormal_pituitary_gland	2.14633288
9	MP0008877_abnormal_DNA_methylation	2.14156603
10	MP0008872_abnormal_physiological_respon	2.12122027
11	MP0004147_increased_porphyrin_level	1.99149720
12	MP0002876_abnormal_thyroid_physiology	1.98840330
13	MP0005084_abnormal_gallbladder_morpholo	1.86357452
14	MP0003646_muscle_fatigue	1.85379500
15	MP0005645_abnormal_hypothalamus_physiol	1.84556803
16	MP0005551_abnormal_eye_electrophysiolog	1.82965354
17	MP0003787_abnormal_imprinting	1.82709131
18	MP0001986_abnormal_taste_sensitivity	1.75306972
19	MP0004142_abnormal_muscle_tone	1.74533573
20	MP0003011_delayed_dark_adaptation	1.74031242
21	MP0001873_stomach_inflammation	1.73330581
22	MP0008875_abnormal_xenobiotic_pharmacok	1.70782773
23	MP0009785_altered_susceptibility_to	1.69381588
24	MP0004885_abnormal_endolymph	1.65395721
25	MP0002148_abnormal_hypersensitivity_rea	1.63626544
26	MP0004145_abnormal_muscle_electrophysio	1.61082790
27	MP0000372_irregular_coat_pigmentation	1.54436357
28	MP0001800_abnormal_humoral_immune	1.51214995
29	MP0005075_abnormal_melanosome_morpholog	1.46109824
30	MP0002166_altered_tumor_susceptibility	1.45904869
31	MP0001968_abnormal_touch/_nociception	1.42274625
32	MP0005389_reproductive_system_phenotype	1.39285867
33	MP0005253_abnormal_eye_physiology	1.38429739
34	MP0003806_abnormal_nucleotide_metabolis	1.37805866
35	MP0009764_decreased_sensitivity_to	1.33284188
36	MP0002138_abnormal_hepatobiliary_system	1.33070669
37	MP0003195_calcinosis	1.30879835
38	MP0008995_early_reproductive_senescence	1.30856977
39	MP0001790_abnormal_immune_system	1.26778617
40	MP0005387_immune_system_phenotype	1.26778617
41	MP0006276_abnormal_autonomic_nervous	1.26557708
42	MP0002006_tumorigenesis	1.26298795
43	MP0001905_abnormal_dopamine_level	1.26091048
44	MP0005000_abnormal_immune_tolerance	1.25318826
45	MP0009333_abnormal_splenocyte_physiolog	1.25279362
46	MP0001529_abnormal_vocalization	1.25096229
47	MP0002272_abnormal_nervous_system	1.25050295
48	MP0002163_abnormal_gland_morphology	1.23543157
49	MP0000685_abnormal_immune_system	1.22192874
50	MP0001919_abnormal_reproductive_system	1.22052421
51	MP0002234_abnormal_pharynx_morphology	1.19701229
52	MP0005174_abnormal_tail_pigmentation	1.12320596
53	MP0002723_abnormal_immune_serum	1.07538925
54	MP0003880_abnormal_central_pattern	1.06923236
55	MP0008789_abnormal_olfactory_epithelium	1.06089472
56	MP0002160_abnormal_reproductive_system	1.05099030
57	MP0002095_abnormal_skin_pigmentation	1.03997369
58	MP0001501_abnormal_sleep_pattern	1.03759220
59	MP0002452_abnormal_antigen_presenting	1.03293646
60	MP0002638_abnormal_pupillary_reflex	1.03181831
61	MP0003567_abnormal_fetal_cardiomyocyte	1.01849559
62	MP0001485_abnormal_pinna_reflex	1.00098445
63	MP0003724_increased_susceptibility_to	0.98695381
64	MP0001293_anophthalmia	0.98645396
65	MP0006036_abnormal_mitochondrial_physio	0.98062352
66	MP0001764_abnormal_homeostasis	0.97645727
67	MP0002736_abnormal_nociception_after	0.96728143
68	MP0009745_abnormal_behavioral_response	0.96670723
69	MP0001819_abnormal_immune_cell	0.94196412
70	MP0002420_abnormal_adaptive_immunity	0.93341902
71	MP0003186_abnormal_redox_activity	0.92727615
72	MP0000631_abnormal_neuroendocrine_gland	0.90970306
73	MP0001970_abnormal_pain_threshold	0.90963784
74	MP0003763_abnormal_thymus_physiology	0.89222567
75	MP0005377_hearing/vestibular/ear_phenot	0.88742482
76	MP0003878_abnormal_ear_physiology	0.88742482
77	MP0002653_abnormal_ependyma_morphology	0.87767183
78	MP0005636_abnormal_mineral_homeostasis	0.86749367
79	MP0001765_abnormal_ion_homeostasis	0.85774299
80	MP0003786_premature_aging	0.85238396
81	MP0001984_abnormal_olfaction	0.84835461
82	MP0005360_urolithiasis	0.83973633
83	MP0002938_white_spotting	0.83363970
84	MP0005379_endocrine/exocrine_gland_phen	0.83115525
85	MP0001486_abnormal_startle_reflex	0.82370795
86	MP0010386_abnormal_urinary_bladder	0.82299614
87	MP0003283_abnormal_digestive_organ	0.81640120
88	MP0010155_abnormal_intestine_physiology	0.80792829
89	MP0004742_abnormal_vestibular_system	0.80384112
90	MP0001440_abnormal_grooming_behavior	0.79990086
91	MP0005195_abnormal_posterior_eye	0.79762855
92	MP0005025_abnormal_response_to	0.79641611
93	MP0002572_abnormal_emotion/affect_behav	0.77620200
94	MP0002733_abnormal_thermal_nociception	0.76569149
95	MP0000230_abnormal_systemic_arterial	0.75906012
96	MP0006082_CNS_inflammation	0.75427718
97	MP0000049_abnormal_middle_ear	0.75368258
98	MP0003121_genomic_imprinting	0.75352132
99	MP0003252_abnormal_bile_duct	0.75293293
100	MP0009046_muscle_twitch	0.73192802

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.08937547
2	Mitochondrial inheritance (HP:0001427)	3.93735200
3	Congenital stationary night blindness (HP:0007642)	3.91103782
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.64670097
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57938001
6	Increased CSF lactate (HP:0002490)	3.55036999
7	Acute encephalopathy (HP:0006846)	3.47768616
8	Progressive macrocephaly (HP:0004481)	3.43886142
9	Hepatocellular necrosis (HP:0001404)	3.38822024
10	Increased hepatocellular lipid droplets (HP:0006565)	3.32498070
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.32280413
12	Molar tooth sign on MRI (HP:0002419)	3.25908601
13	Abnormality of midbrain morphology (HP:0002418)	3.25908601
14	Abolished electroretinogram (ERG) (HP:0000550)	3.19928402
15	Lipid accumulation in hepatocytes (HP:0006561)	3.19175304
16	Congenital, generalized hypertrichosis (HP:0004540)	3.11079694
17	3-Methylglutaconic aciduria (HP:0003535)	3.05198801
18	Hepatic necrosis (HP:0002605)	3.03235599
19	Pancreatic cysts (HP:0001737)	2.97911649
20	Renal Fanconi syndrome (HP:0001994)	2.92946686
21	IgG deficiency (HP:0004315)	2.90572950
22	Reticulocytopenia (HP:0001896)	2.89743698
23	Optic disc pallor (HP:0000543)	2.78181564
24	Abnormality of cells of the erythroid lineage (HP:0012130)	2.67914186
25	Pancreatic fibrosis (HP:0100732)	2.67331020
26	Increased intramyocellular lipid droplets (HP:0012240)	2.63153285
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.61646426
28	Cerebral edema (HP:0002181)	2.58209125
29	Abnormality of B cell number (HP:0010975)	2.57896145
30	Nephronophthisis (HP:0000090)	2.56639175
31	Decreased central vision (HP:0007663)	2.54570101
32	True hermaphroditism (HP:0010459)	2.54092219
33	Elevated erythrocyte sedimentation rate (HP:0003565)	2.54037534
34	Abnormality of the prostate (HP:0008775)	2.50931015
35	Macrocytic anemia (HP:0001972)	2.50450793
36	Hypoproteinemia (HP:0003075)	2.49942515
37	Exertional dyspnea (HP:0002875)	2.49090904
38	Attenuation of retinal blood vessels (HP:0007843)	2.48594525
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.46856743
40	Absent/shortened dynein arms (HP:0200106)	2.46856743
41	Panhypogammaglobulinemia (HP:0003139)	2.42393553
42	Constricted visual fields (HP:0001133)	2.40756189
43	Stenosis of the external auditory canal (HP:0000402)	2.40593123
44	Medial flaring of the eyebrow (HP:0010747)	2.40031776
45	Severe combined immunodeficiency (HP:0004430)	2.32125395
46	Abnormality of the renal cortex (HP:0011035)	2.26556517
47	Increased serum lactate (HP:0002151)	2.24765236
48	Methylmalonic acidemia (HP:0002912)	2.24733220
49	Increased muscle lipid content (HP:0009058)	2.20680292
50	Type II lissencephaly (HP:0007260)	2.19655220
51	Thyroiditis (HP:0100646)	2.19631819
52	Abnormality of the renal medulla (HP:0100957)	2.19192547
53	Lactic acidosis (HP:0003128)	2.18440744
54	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17988770
55	Asplenia (HP:0001746)	2.17418634
56	B lymphocytopenia (HP:0010976)	2.16830550
57	Abnormal number of erythroid precursors (HP:0012131)	2.16785348
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14788168
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14788168
60	Pallor (HP:0000980)	2.13377706
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.10720224
62	Renal cortical cysts (HP:0000803)	2.09181164
63	Aplastic anemia (HP:0001915)	2.02529893
64	Abnormal respiratory epithelium morphology (HP:0012253)	2.02320919
65	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02320919
66	Glycosuria (HP:0003076)	2.01810056
67	Abnormality of urine glucose concentration (HP:0011016)	2.01810056
68	Stomatitis (HP:0010280)	2.01552098
69	Abnormality of renal resorption (HP:0011038)	2.00626221
70	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.96967121
71	Abnormality of alanine metabolism (HP:0010916)	1.95664849
72	Hyperalaninemia (HP:0003348)	1.95664849
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95664849
74	Lethargy (HP:0001254)	1.93170314
75	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.91088858
76	Abnormal ciliary motility (HP:0012262)	1.90023131
77	Leukodystrophy (HP:0002415)	1.87789386
78	Abnormality of DNA repair (HP:0003254)	1.87744169
79	Absent thumb (HP:0009777)	1.87000795
80	Polydipsia (HP:0001959)	1.85852709
81	Abnormal drinking behavior (HP:0030082)	1.85852709
82	Respiratory failure (HP:0002878)	1.83701328
83	Type 2 muscle fiber atrophy (HP:0003554)	1.83041922
84	Increased corneal curvature (HP:0100692)	1.81944063
85	Keratoconus (HP:0000563)	1.81944063
86	Dyschromatopsia (HP:0007641)	1.81623603
87	Abnormality of T cell number (HP:0011839)	1.78951057
88	Pendular nystagmus (HP:0012043)	1.77824929
89	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.76855440
90	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74311314
91	Chronic mucocutaneous candidiasis (HP:0002728)	1.73659744
92	Recurrent cutaneous fungal infections (HP:0011370)	1.73659744
93	Methylmalonic aciduria (HP:0012120)	1.72582476
94	Hypothermia (HP:0002045)	1.72433545
95	Sclerocornea (HP:0000647)	1.72426637
96	Abnormal hemoglobin (HP:0011902)	1.69478245
97	Bile duct proliferation (HP:0001408)	1.69165391
98	Abnormal biliary tract physiology (HP:0012439)	1.69165391
99	Abnormality of T cells (HP:0002843)	1.69010700
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.68324068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.38863780
2	MAP4K2	3.06113205
3	TAOK3	3.05649811
4	TLK1	2.94336153
5	TXK	2.75297110
6	ADRBK2	2.73048476
7	GRK1	2.61464300
8	NUAK1	2.54067344
9	ZAK	2.52025574
10	FRK	2.34266145
11	MAP3K12	2.22791672
12	WNK4	2.02848780
13	BCKDK	1.96811771
14	BMPR2	1.77813230
15	TIE1	1.77666599
16	BMPR1B	1.73353501
17	KIT	1.69877460
18	PINK1	1.69623598
19	WNK3	1.63004037
20	TEC	1.60079075
21	VRK2	1.60001505
22	STK16	1.43255463
23	INSRR	1.39658565
24	VRK1	1.36717782
25	FLT3	1.36310320
26	KDR	1.31671259
27	OXSR1	1.26150108
28	ITK	1.25062992
29	CSF1R	1.24178236
30	GRK6	1.20258353
31	SYK	1.19591327
32	IKBKB	1.11671774
33	SCYL2	1.06890202
34	MYLK	1.05307400
35	DYRK2	1.00252625
36	TNK2	0.96069131
37	MUSK	0.92897250
38	PASK	0.92725901
39	FES	0.91374817
40	EIF2AK3	0.87824926
41	MAP4K1	0.87192396
42	STK39	0.86766234
43	MAPK13	0.85156124
44	PRKCQ	0.85113533
45	CSNK1G1	0.85080754
46	CDK8	0.80025344
47	CSNK1G3	0.78889750
48	CSNK1G2	0.78510133
49	BTK	0.76256307
50	PHKG2	0.75993894
51	PHKG1	0.75993894
52	LYN	0.74625861
53	MKNK1	0.73755030
54	TRPM7	0.73658018
55	RPS6KA5	0.73391531
56	DAPK2	0.73212956
57	MAP3K4	0.73178668
58	MAP2K6	0.72798917
59	PRKCE	0.71600093
60	ERBB3	0.70956027
61	ADRBK1	0.70407256
62	ILK	0.69990435
63	DAPK3	0.68115509
64	CAMKK2	0.67000279
65	CDK3	0.66870536
66	OBSCN	0.65835750
67	PIK3CA	0.65125331
68	LCK	0.64338081
69	MAP2K7	0.64041229
70	MAPKAPK5	0.63400119
71	DAPK1	0.62223902
72	ACVR1B	0.60204182
73	IKBKE	0.57850116
74	PIK3CG	0.57263269
75	IGF1R	0.56702600
76	MST4	0.55706570
77	NEK1	0.55593343
78	PRKACA	0.53800066
79	RPS6KA4	0.51908614
80	PRKCG	0.47207044
81	PIM1	0.47130302
82	CSNK1A1L	0.46610961
83	PRKCA	0.45588172
84	CSNK2A2	0.44772154
85	CSNK2A1	0.43301947
86	JAK3	0.42708507
87	CAMK2A	0.41914670
88	NEK2	0.41844032
89	TGFBR1	0.40538786
90	MATK	0.40333782
91	CSNK1A1	0.40129524
92	PRKCD	0.38816637
93	GRK7	0.37369003
94	PLK2	0.37359930
95	CAMK1	0.36498298
96	AURKB	0.34569232
97	ABL1	0.33917416
98	PRKG1	0.33546984
99	PLK3	0.33174266
100	NME1	0.32844162

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.13264489
2	Ribosome_Homo sapiens_hsa03010	3.91573680
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.44862709
4	Allograft rejection_Homo sapiens_hsa05330	3.35839192
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.12113147
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.06218349
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.99853235
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.78772006
9	Parkinsons disease_Homo sapiens_hsa05012	2.75175712
10	Proteasome_Homo sapiens_hsa03050	2.65797263
11	Protein export_Homo sapiens_hsa03060	2.34768093
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.94993274
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.92031721
14	Alzheimers disease_Homo sapiens_hsa05010	1.89537129
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87424728
16	RNA polymerase_Homo sapiens_hsa03020	1.84195306
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.76973786
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.75797958
19	Huntingtons disease_Homo sapiens_hsa05016	1.75298928
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63970477
21	Phototransduction_Homo sapiens_hsa04744	1.61631926
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58124060
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.57503589
24	Homologous recombination_Homo sapiens_hsa03440	1.39776362
25	RNA degradation_Homo sapiens_hsa03018	1.38954900
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.35260658
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34694724
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30708526
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.23568671
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.20439508
31	Viral myocarditis_Homo sapiens_hsa05416	1.14686694
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12997576
33	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.11099255
34	Caffeine metabolism_Homo sapiens_hsa00232	1.04291523
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.01755824
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00727776
37	Basal transcription factors_Homo sapiens_hsa03022	0.95702103
38	Olfactory transduction_Homo sapiens_hsa04740	0.95442000
39	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91458990
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90276956
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.87009641
42	One carbon pool by folate_Homo sapiens_hsa00670	0.86129534
43	Propanoate metabolism_Homo sapiens_hsa00640	0.85229921
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82321301
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82057231
46	Butanoate metabolism_Homo sapiens_hsa00650	0.80781418
47	Peroxisome_Homo sapiens_hsa04146	0.80729955
48	Nicotine addiction_Homo sapiens_hsa05033	0.79552556
49	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77806589
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76829359
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76537098
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.75045474
53	Regulation of autophagy_Homo sapiens_hsa04140	0.74469685
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73522329
55	Retinol metabolism_Homo sapiens_hsa00830	0.73303506
56	Leishmaniasis_Homo sapiens_hsa05140	0.73298166
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72346654
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.72126746
59	Purine metabolism_Homo sapiens_hsa00230	0.70182871
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69252384
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68955018
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68868185
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66271564
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66184505
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64735321
66	Taste transduction_Homo sapiens_hsa04742	0.62071601
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.58238376
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58134584
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51086256
70	Salivary secretion_Homo sapiens_hsa04970	0.49729818
71	Metabolic pathways_Homo sapiens_hsa01100	0.48342253
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45812118
73	Spliceosome_Homo sapiens_hsa03040	0.45612994
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44417116
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43393904
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43079192
77	African trypanosomiasis_Homo sapiens_hsa05143	0.42948288
78	Mismatch repair_Homo sapiens_hsa03430	0.42209711
79	RNA transport_Homo sapiens_hsa03013	0.42025404
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41026256
81	Morphine addiction_Homo sapiens_hsa05032	0.40292567
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39489794
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38822317
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36530005
85	Serotonergic synapse_Homo sapiens_hsa04726	0.30446772
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.29526497
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.28660704
88	Base excision repair_Homo sapiens_hsa03410	0.28455055
89	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28189018
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28138695
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.26323578
92	Mineral absorption_Homo sapiens_hsa04978	0.25183028
93	Circadian entrainment_Homo sapiens_hsa04713	0.24220711
94	Herpes simplex infection_Homo sapiens_hsa05168	0.23967167
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.23161620
96	GABAergic synapse_Homo sapiens_hsa04727	0.22439807
97	Glutathione metabolism_Homo sapiens_hsa00480	0.22430105
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21307934
99	Tuberculosis_Homo sapiens_hsa05152	0.20851444
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.20278440

RPS3AP49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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